With Radioactive Material Patents (Class 422/71)
  • Patent number: 9790465
    Abstract: A spheroid cell culture article including: a frame having a chamber including: an opaque side wall surface; a top aperture; a gas-permeable, transparent bottom; and optionally a chamber annex surface and second bottom, and at least a portion of the transparent bottom includes at least one concave arcuate surface, is disclosed. Methods of making and using the article are also disclosed.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: October 17, 2017
    Assignee: Corning Incorporated
    Inventors: Scott Matthew Bennett, Brian Robb Douglass, Paul Ernest Gagnon, Jr., Gregory Roger Martin, Paul Michael Szlosek, Allison Jean Tanner
  • Patent number: 8298485
    Abstract: Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element preferably supports a single microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: October 30, 2012
    Inventors: Lee Angros, Thomas Lee Byers
  • Patent number: 8262997
    Abstract: A blood counting device comprises a capillary conduit for drawing from a subject in which a radiotracer has previously been injected a quantity of blood in the micro-liter range to produce in the capillary conduit a flow of blood from which beta radiation is emitted. At least one direct beta radiation detector is placed closely adjacent to the capillary conduit. The direct beta radiation detector consists of a semiconductor photodiode which detects the beta radiation from the flow of blood when directly hit by this beta radiation.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: September 11, 2012
    Assignee: Société de Commercialisation des Produits de la Recherche Appliquée-Socpra Sciences Sante et Humaines S.E.C.
    Inventors: Laurence Convert, Jules Cadorette, David Lapointe, Roger Lecomte
  • Patent number: 8182754
    Abstract: The apparatus is proposed for termination of radioactive and other wastes particularly for physical processing of radioactive waste with simultaneous production of hydrogen, oxygen, and electric energy. It includes an ion divider, a plasma chamber communicated with the ion divider, a controllable hydrogen-oxygen dispenser introducing hydrogen and oxygen into the plasma chamber, transformer pipe coils, a transformer chamber surrounded by the transformer coils, the transformer chamber communicated with the plasma chamber, equipment for supplying water and steam into the transformer coils, cooling equipment for receiving ionized steam from the transformer coils and cooling the steam, a sprayer receiving the ionized steam from the cooling equipment and introducing the steam into the ion divider; and dispenser equipment for introducing radio-active wastes and/or worked-out rocket fuels into the transformer chamber, wherein the radio-active wastes and/or worked-out rocket fuels are terminated.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: May 22, 2012
    Inventors: Yuriy Yatsenko, Boris Avramchuk, Siarhei Zmitkovich, Roman Pankiv, Vadim Yatsenko
  • Patent number: 7985589
    Abstract: The invention provides a calibrating method for use in a method of determining the quantity of an analyte labeled with an accelerator mass spectrometry (AMS) isotope in a test sample. The samples can include, for example, urine, faeces, plasma or blood. The analyte can be, for example, a drug or metabolite of a drug.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: July 26, 2011
    Assignee: Xceleron, Limited
    Inventors: Ronald Colin Garner, Graham John Lappin
  • Patent number: 7892857
    Abstract: The invention relates to an assay method and a fluid microsystem for carrying out said assay method, in particular, for carrying out miniaturized affinity tests in a micro-array format. According to said invention, a liquid phase comprising at least one type of detectable high-molecular weight soluble substance, for example a labeled reaction partner or product of an affinity reaction is displaced by the hydraulic effect of a high-molecular weight osmotic agent on an ultrafiltration membrane towards a miniaturized measuring chamber defined thereby. The fraction of the detectable high-molecular weight substance(s) is concentrated in the measuring chamber, while the dissolved low-molecular weight components are removed with the solvent through the membrane pores, thereby making it possible to attain a high detection sensitivity.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: February 22, 2011
    Inventors: Rudolf Ehwald, Helge Adleff, Frank Bier, Nenad Gajovic-Eichelmann, Max Ehwald
  • Patent number: 7776266
    Abstract: A food testing device for testing for the presence of harmful contaminants in a food sample, includes a vessel adapted for holding a liquefied food sample, a liquefier operatively associated with the vessel for converting an unliquefied food sample into a liquefied food sample, at least one test assay dispensable from the device, wherein the test assay includes at least one assay reagent having an affinity for at least one harmful contaminant, and capable of both detecting the presence of the harmful contaminant in the liquefied food sample, and producing a visual cue upon recognition of the harmful contaminant; and a radiation detector disposed proximately to the vessel for indicating the presence of ionizing radiation in the food sample at amounts exceeding normal background levels to detect the presence of a radioactive agent as the harmful contaminant.
    Type: Grant
    Filed: January 20, 2009
    Date of Patent: August 17, 2010
    Assignee: Harrogate Holdings
    Inventor: Robert B. Royds
  • Patent number: 7673497
    Abstract: System, methods, and compositions are described for detecting and inhibiting leaks of a transmission system. The composition may include one or more transmission system sealants and one or more light activated compounds. The transmission system sealant(s) inhibit one or more of the leaks in the transmission system. One or more of the light activated compounds are visible when activating light is directed towards a portion of the exterior of the transmission system.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: March 9, 2010
    Assignee: IDQ Operating, Inc.
    Inventors: William J. Quest, Darrell W. Patton
  • Patent number: 7618827
    Abstract: Methods, systems and kits for the simultaneous or sequential analysis of one or more hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal preparation time. The methods include ionizing the hormones and analyzing the hormones by mass spectrometry. In addition, methods, systems and kits for the simultaneous or sequential analysis of thyroid hormones are disclosed including ionization of the thyroid hormones in the negative mode using an electrospray source.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: November 17, 2009
    Assignee: Georgetown University
    Inventor: Soldin J. Steven
  • Patent number: 7605384
    Abstract: The invention relates to an apparatus for preparing a small amount of a radioactive substance combination, including a one-part body, a mixing device integrated in the body and adapted to receive a small amount of chemical substances, and at least one receptacle integrated in the body and connected to the mixing device and adapted to hold a small amount of a chemical substance.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: October 20, 2009
    Assignee: Isotopen Technologien Munchen AG
    Inventors: Julian Bernd Sonnenhol, Andreas Eursch, Mark Harfensteller, Michael Schilp, Oliver Buck, Lisa Maria Ehrenfried, Tuomo Nikula
  • Patent number: 7565830
    Abstract: System, methods, and compositions are described for detecting and inhibiting leaks of an engine oil system. The composition may include an engine oil system sealant and a light activated compound. The engine oil system sealant(s) inhibit leak(s) in the engine oil system. One or more of the light activated compounds are visible when an activating light source is directed towards a portion of the engine oil system.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: July 28, 2009
    Assignee: E.F. Products
    Inventors: William J. Quest, Darrell W. Patton
  • Patent number: 7565829
    Abstract: System, methods, and compositions are described for detecting and inhibiting leaks of a steering system. The composition may include one or more steering system sealants and one or more light activated compounds. The steering system sealant(s) inhibit one or more leaks in the steering system. One or more of the light activated compound are visible when activating light is directed towards a portion of the steering system.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: July 28, 2009
    Assignee: E.F. Products
    Inventors: William J. Quest, Darrell W. Patton
  • Patent number: 7527765
    Abstract: A food testing device for testing for the presence of harmful contaminants in a food sample, includes a vessel adapted for holding a liquefied food sample, a liquefier operatively associated with the vessel for converting an unliquefied food sample into a liquefied food sample, at least one test assay dispensable from the device, wherein the test assay includes at least one assay reagent having an affinity for at least one harmful contaminant, and capable of both detecting the presence of the harmful contaminant in the liquefied food sample, and producing a visual cue upon recognition of the harmful contaminant; and a radiation detector disposed proximately to the vessel for indicating the presence of ionizing radiation in the food sample at amounts exceeding normal background levels to detect the presence of a radioactive agent as the harmful contaminant.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: May 5, 2009
    Assignee: Harrogate Holdings
    Inventor: Robert B. Royds
  • Publication number: 20080200747
    Abstract: One aspect of the present invention is directed to a system for power filling a syringe with a radiopharmaceutical from a vial while attempting to provide low exposure to radiation, and thereafter, power injecting the radiopharmaceutical. A radiation-shielded container of the system generally holds the vial. A filling and injecting device of the system generally includes a mounting structure adapted to support the syringe with a needle of the syringe located in the vial. An electromechanical drive of the system may be commanded by a control to pull a syringe plunger through a controlled motion, thereby filling the syringe.
    Type: Application
    Filed: May 16, 2006
    Publication date: August 21, 2008
    Inventors: Gary S. Wagner, Frank M. Fago, Keith M. Grispo, Chad M. Gibson, John H. Lewis, William E. Bausmith, Elaine E. Haynes, David W. Wilson, Vernon D. Ortenzi, Elaine Borgemenke
  • Patent number: 7101719
    Abstract: Disclosed is a method for the measurement of a cellular process, or for the measurement of the effect of a test compound on a cellular process, in one or more different populations of cells. The method comprises providing separate samples of one or more different populations of cells adhering to support particles, the support particles comprising a scintillant substance and being adapted for cell growth. In one embodiment, different samples of cells are introduced into separate reaction vessels in a fluid medium, together with a reagent labelled with a radioisotope, in the presence or the absence of the test compound, under conditions so as to cause a portion of said radiolabelled reagent to become associated with the cells. In another embodiment, multiparameter analysis may be performed to determine the effect of a test compound on a cellular process using two or more different cell populations present in the same well.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: September 5, 2006
    Assignee: GE Healthcare Limited
    Inventors: Gerard Bernard O'Beirne, Rahman Aziz Ismail, Nicholas Thomas
  • Patent number: 6861214
    Abstract: An assay article for detection biopolymers contained in a sample is described. The assay article includes a substrate and a biopolymer directly adsorbed on the surface of the substrate. A plurality of biopolymers may be adsorbed on the surface of the substrate to form an array. Also disclosed is a method of making the assay article. In the preferred method, an aminated polypropylene substrate is used. A biopolymer is contacted with the aminated substrate under a condition sufficient for direct adsorption of the biopolymer on the surface of the substrate. A method of detecting a target biopolymer contained in a sample is also disclosed. In this method, a substrate is contacted with either a probe or target biopolymer under a condition sufficient for a direct adsorption of either the probe or target biopolymer on the substrate to form a probe assay article or a target assay article.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: March 1, 2005
    Assignee: Beckman Coulter, Inc.
    Inventors: Jang B. Rampal, Robert S. Matson
  • Publication number: 20040251206
    Abstract: The invention encompasses systems for column-based separations, methods of packing and unpacking columns and methods of separating components of samples. In one aspect, the invention includes a method of packing and unpacking a column chamber, comprising: a) packing a matrix material within a column chamber to form a packed column; and b) after the packing, unpacking the matrix material from the column chamber without moving the column chamber.
    Type: Application
    Filed: May 28, 2004
    Publication date: December 16, 2004
    Inventors: Oleg B. Egorov, Matthew J. O'Hara, Jay W. Grate, Darrell P. Chandler, Fred J. Brockman, Cynthia J. Bruckner-Lea
  • Publication number: 20040253147
    Abstract: The invention relates to a method for automatically carrying out chromatographic analyses. According to said method, at least one of the following pieces of information is obtained: a) the retention times of at least one constituent; b) the temperature; c) the structural formulae of at least one of the constituents; d) the type of elution agent; and e) the parameters of the separation column. For extensive optimisation, the invention is characterised in that the data obtained is optionally completed by available data, at least one first test run is carried out under isocratic conditions, and retention times are detected or calculated on the basis of a model with optimisation parameters. The retention times obtained are optimised by varying the parameters, another chromatography run is carried out with the parameters of the optimised retention times, and a comparison is made with the measured retention times. The above-mentioned steps are optionally repeated for further optimisation.
    Type: Application
    Filed: December 12, 2003
    Publication date: December 16, 2004
    Inventor: Sergey Golushko
  • Patent number: 6794130
    Abstract: Nucleic acid is captured from a mixture of cellular debris produced by cell lysis by exposing the mixture to an electrode and applying a nucleic acid capturing voltage to the electrode which is then removed from the mixture carrying said nucleic acid. The nucleic acid is undamaged and can be amplified by PCR.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: September 21, 2004
    Assignee: Affymetrix, Inc.
    Inventors: Denise Vera Pollard-Knight, Sophie Elizabeth Victoria Martin, Susan Watson
  • Publication number: 20040175833
    Abstract: An automatic sampler comprises a first rinsing bath for rinsing the needle by soaking the needle in a rinsing liquid, in which the rinsing liquid is reserved, and a second rinsing bath for rinsing the needle by soaking the needle in a rinsing liquid, in which the rinsing liquid is exchanged during the rinsing operation. The first rinsing bath and the second rinsing bath are selectively employed for the purpose of use. That is, when a high rinsing power is required, such as when cross contamination is prevented, the second rinsing bath having higher rinsing power is employed. On the other hand, when the throughput is emphasized, the first rinsing bath is employed to rinse the needle in a shorter time.
    Type: Application
    Filed: February 17, 2004
    Publication date: September 9, 2004
    Applicant: SHIMADZU CORPORATION
    Inventor: Nobuyuki Tatsumi
  • Patent number: 6660229
    Abstract: Methods and kits that use nucleotide analogs to confer increased accuracy and improved resolution in the analysis and sequencing of oligonucleotide mixtures are provided.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: December 9, 2003
    Assignee: The Trustees of Boston University
    Inventors: Charles R. Cantor, Fouad A. Siddiqi
  • Patent number: 6602716
    Abstract: A method and device for fluorimetric determination of a biological, chemical or physical parameter of a sample utilize at least two different luminescent materials, the first of which is sensitive to the parameter, at least with respect to luminescence intensity, and the second of which is insensitive to the parameter, at least with respect to luminescence intensity and decay time. The luminescent materials have different decay times. The time- or phase behaviour of the resulting luminescence response is used to form a reference value for determination of a parameter.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: August 5, 2003
    Assignee: PreSens Precision Sensing GmbH
    Inventor: Ingo Klimant
  • Patent number: 6576470
    Abstract: The invention pertains to a process for examining chemical reactions in the presence of potentially catalytical substances, wherein reactions are triggered in miniaturized reactors with volumes of 0.001 cm3 to 1 cm3 arranged parallel to each other, and the nature and amount of the reaction mixture are analyzed during the reaction time.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: June 10, 2003
    Assignee: Aventis Research & Technologies GmbH & Co KG
    Inventors: Norbert Windhab, Christian Miculka, Hans-Ulrich Hoppe
  • Patent number: 6572823
    Abstract: An apparatus and method are provided for handling a solution. The apparatus comprises a housing and a vial assembly positioned within an enclosure of the housing. The vial assembly maintains at least one vial within the enclosure of the housing. A valve manifold extends within the enclosure of the housing for connection to the vial. A rotation mechanism, also extending within the enclosure of the housing, is operatively connected to the vial assembly for rotating the vial assembly.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: June 3, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: John J. Donahue, Joseph Haepers
  • Publication number: 20020176800
    Abstract: A packed miniature liquid chromatography column having a curved or a coiled configuration for direct coupling to liquid chromatographic equipment is disclosed. The column may be encased by a housing for protection during handling and use.
    Type: Application
    Filed: May 9, 2002
    Publication date: November 28, 2002
    Inventors: Richard A. Henry, Chia-Hui Paul Shieh
  • Publication number: 20020172619
    Abstract: An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray.
    Type: Application
    Filed: May 31, 2002
    Publication date: November 21, 2002
    Inventors: James E. Moon, Timothy J. Davis, Gregory J. Galvin, Gary A. Schultz, Thomas N. Corso, Stephen Lowes
  • Publication number: 20020172618
    Abstract: An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray.
    Type: Application
    Filed: May 31, 2002
    Publication date: November 21, 2002
    Inventors: James E. Moon, Timothy J. Davis, Gregory J. Galvin, Gary A. Schultz, Thomas N. Corso, Stephen Lowes
  • Publication number: 20020072126
    Abstract: A reconfigurable multi-mode post-column analysis system improves resolution of liquid chromatography detection data by providing a parking or MS/MS detection mode in which flow of column eluent is substantially reduced to provide greater analysis time within a single eluting detection peak. A micro switching valve unit is reconfigurable between normal (MS) mode that passes column eluent directly to an MS unit, and a peak parking (or MS/MS) mode, in which normal mode column flow is interrupted, and the gradient halted, while more slowly flowing the detection peak of interest through the MS unit. A micro syringe pump contributes to the substantially lower MS/MS flow rate. A MS control unit controls micro switching valve valves to reconfigure between MS and MS/MS modes. After a detection peak, MS mode is reestablished, and the system primary pump returns to normal mode flow rate and gradient conditions. Mode changes can be carried out for each chromatogram detection peak.
    Type: Application
    Filed: October 3, 2001
    Publication date: June 13, 2002
    Applicant: DIONEX CORPORATION
    Inventors: Jean-Pierre Chervet, Remco Swart, Johannes Petrus Cornelus Vissers
  • Patent number: 6403771
    Abstract: The present invention relates to the field of site directed therapy. More specifically the invention relates to site directed radio therapy, and provides a method for production of radioconjugates and an apparatus for radioimmunotherapy. The method, conjugates and apparatus can be practicalized without the need for radioactive shielding and/or airtight facilities. Without these restrictions the invention provides a simple and efficient means of therapy at the bed-side of the patient.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: June 11, 2002
    Assignee: Actinium Pharmaceuticals, Limited
    Inventor: Maurits W. Geerlings
  • Patent number: 6207111
    Abstract: A system for describing the physical distribution of an agent that accumulates selectively in tissue of a patient in an excised surgical specimen. The system comprises an agent which selectively concentrates in a cancer or precancer or focus of infection or other pathological condition. The system comprises a detector sensitive to the agent which is present in the surgical specimen. The system also comprises an apparatus capable of forming an image based on the information gathered by the detector, and which image describes the physical distribution of the agent in the surgical specimen so that a surgeon can be guided by the image provided by the apparatus, said apparatus connected to said detector.
    Type: Grant
    Filed: December 31, 1997
    Date of Patent: March 27, 2001
    Assignee: PEM Technologies, Inc.
    Inventor: Irving N. Weinberg
  • Patent number: 6126901
    Abstract: An apparatus and method for detecting low levels of one or more radionuclides in a fluid sample uses a substrate that includes an ion exchange resin or other sorbent material to collect the radionuclides. A collecting apparatus includes a collecting chamber that exposes the substrate to a measured amount of the fluid sample such that radionuclides in the fluid sample are collected by the ion exchange resin. A drying apparatus, which can include a drying chamber, then dries the substrate. A measuring apparatus measures emissions from radionuclides collected on the substrate. The substrate is positioned in a measuring chamber proximate to a detector, which provides a signal in response to emissions from the radionuclides. Other analysis methods can be used to detect non-radioactive analytes, which can be collected with other types of sorbent materials.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: October 3, 2000
    Assignee: Thermo Power Corporation
    Inventors: Keith D. Patch, Dean T. Morgan
  • Patent number: 6127527
    Abstract: The present invention relates to the field of site directed therapy. More specifically it relates to site directed radio therapy. It provides a method for production of radioimmuno conjugates and an apparatus for radioimmuno therapy. The method, conjugates and apparatus can be practicalized without the need for radioactive shielding and/or airtight facilities. Without these restrictions the invention provides a simple and efficient means of therapy at the bed-side of the patient.
    Type: Grant
    Filed: January 5, 1998
    Date of Patent: October 3, 2000
    Assignee: Akzo Nobel N.V.
    Inventor: Maurits Willem Geerlings
  • Patent number: 6103533
    Abstract: A method of identifying individual substances within a mixture of substances comprises causing the mixture to travel past a spaced series of detectors, each being arranged to produce a signal representative of a characteristic of the mixture as it passes, repeatedly measuring the signals from each detector at a plurality of times, transforming into velocity space, and identifying individual substances within the mixture according to the peaks they create in velocity space.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: August 15, 2000
    Assignee: Imperial College of Science, Technology and Medicine
    Inventors: John Francis Hassard, David John Colling
  • Patent number: 5989854
    Abstract: A vessel, or an array of vessels, in the form of a multiwell plate, wherein the side walls are opaque and non-scintillant, and wherein the base comprises a scintillant substance, said base being formed of a plastics material which does not permit the attachment or growth of cells.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: November 23, 1999
    Assignee: Amersham International plc
    Inventor: Neil David Cook
  • Patent number: 5700637
    Abstract: This invention provides an apparatus and method for analyzing a polynucleotide sequence; either an unknown sequence or a known sequence. A support, e.g. a glass plate, carries an array of the whole or a chosen part of a complete set of oligonucleotides which are capable of taking part in hybridization reactions. The array may comprise one or more pair of oligonucleotides of chosen lengths. The polynucleotide sequence, or fragments thereof, are labelled and applied to the array under hybridizing conditions. Applications include analyses of known point mutations, genomic fingerprinting, linkage analysis, characterization of mRNAs, mRNA populations, and sequence determination.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: December 23, 1997
    Assignee: Isis Innovation Limited
    Inventor: Edwin Southern
  • Patent number: 5668016
    Abstract: A method of activating target proteins in a biologic sample for radioimmunoassay or other immunoassay by adding the sample to a diluent containing no calcium or magnesium, heating the mixture in a boiling water bath for a designated period of time, cooling the sample, centrifuging the mixture to isolate the activated protein containing supernatant, and then vortexing the supernatant to ensure homogeneity of the protein.
    Type: Grant
    Filed: December 29, 1995
    Date of Patent: September 16, 1997
    Inventor: Jose Alberto Fernandez-Pol
  • Patent number: 5665562
    Abstract: Apparatus and method for studying cellular processes comprise a vessel having a base including a layer comprising a scintillant substance and which is adapted for attachment and/or growth of cells. Cellular processes are examined by scintillation proximity assay using a reagent labelled with a radioisotope.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: September 9, 1997
    Assignee: Amersham International plc
    Inventor: Neil David Cook
  • Patent number: 5637506
    Abstract: A method of radiochemical analysis having the steps of providing a solid phase extraction sheet material containing ion-specific sorptive or reactive particles in a porous matrix as carrier for the particles, and providing a fluid including an ion-containing radiochemical analyte, contacting the sheet material with the fluid for a time sufficient for the particles to selectively extract the analyte from the fluid, and analyzing the sheet material in a direct mode for quantitative or qualitative data relating to the radiochemical analyte. Solid phase extraction sheet materials and methods for their preparation are also disclosed.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: June 10, 1997
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Garold L. Goken, Wolfgang H. Strehlow
  • Patent number: 5635403
    Abstract: A tracking and identification card for an air filter specimen, the card having a sheet-like base with a substantially flat support surface for supporting the specimen, the base having a substantially uniform thickness of from about 3 to about 20 mil, and having a focus axis oriented substantially normal to the support surface, a locator area on the support surface and provided with contact adhesive for adhesively holding the specimen in a particular position on the support surface upon contact of the specimen with the adhesive, a sheet-like cover in contact with and substantially overlying the adhesive, the cover being readily removable for exposing the adhesive and allowing the specimen to be placed in contact therewith, and indicia markings on the base for interfacing with an indicia reader for tracking the location and identity of the card within an air monitoring system.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: June 3, 1997
    Assignee: Nuclear Fuel Services, Inc.
    Inventor: William H. Bailey
  • Patent number: 5531964
    Abstract: In order to reduce liquid effluents and solid waste in an analysis chain receiving liquid samples contained in jugs (16), the proposal is to automate all the operations performed in analysis units or boxes (10a, 10b). Moreover, when the sampling operations necessary for the analyses have been carried out in the analysis units (10a, 10b), the jugs can be automatically dispatched to a recycling apparatus (52).
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: July 2, 1996
    Assignee: Compagnie Generale Des Matieres Nucleaires
    Inventor: Joseph Besnier
  • Patent number: 5326532
    Abstract: An apparatus is provided for processing toxic materials in a safe manner. Two access ports in the apparatus are used for introducing and withdrawing the materials. In the apparatus, two valves pass the materials through a vial for mixing with a stored toxic material and a column for processing.
    Type: Grant
    Filed: February 25, 1993
    Date of Patent: July 5, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: William R. Taylor
  • Patent number: 5258309
    Abstract: A method for conducting immunoassays in an automated fashion is disclosed. A biological fluid under test is placed in a tube (11) which has a solid support (18) therein to which a specific analyte in the biological fluid will be selectively bound. After the analyte in the biological fluid is bound to the solid support (18), the tube (11) is rotated at high speed about its longitudinal axis causing the biological fluid to be transported up the inside walls of tube (11), over the open terminal end (16), and into waste chamber (15). The solid support (18) with the bound analyte may easily be washed by flushing the inside of tube (11) with water or other suitable fluids and rotating the tube (11) at high speed about its longitudinal axis.
    Type: Grant
    Filed: October 21, 1991
    Date of Patent: November 2, 1993
    Assignee: Cirrus Diagnostics, Inc.
    Inventors: Arthur L. Babson, John E. Underwood
  • Patent number: 5244635
    Abstract: A centrifuge vessel for performing immunoassays, affinity chromatography, and like experiments includes a center tube and an outer waste chamber. A biomaterial is held within the center tube and is capable of binding specific analytes in test samples. In operation the centrifuge vessel is rotated at high speed about its longitudinal axis, thereby causing all fluid within the center tube to be transported into the outer waste chamber while the analyte of interest remains bound to the biomaterial positioned within the center tube In the centrifuge vessel, a cap connected to the outer waste chamber and extending over the center tube includes structure for preventing waste fluid expelled to the waste chamber from re-entering the center tube. In a first embodiment, the cap is either constructed from or the inside surface is coated with a hydrophobic material which repels fluids back into the waste chamber.
    Type: Grant
    Filed: June 19, 1992
    Date of Patent: September 14, 1993
    Assignee: Cirrus Diagnostics, Inc.
    Inventors: Arthur L. Rabson, Thomas Palmieri, Douglas R. Olson
  • Patent number: 5174962
    Abstract: This invention relates to the apparatus, for sequencing natural or recombinant DNA and other polynucleotides. In particular, this invention relates to a method for sequencing polynucleotides based on mass spectrometry to determine which of the four bases (adenine, guanine, cytosine or thymine) is a component of the terminal nucleotide. In particular, the present invention relates to identifying the individual nucleotides by the mass of stable nuclide markers contained within either the dideoxynucleotides, the DNA primer, or the deoxynucleotide added to the primer. This invention is particularly useful in identifying specific DNA sequences in very small quantities in biological products produced by fermentation or other genetic engineering techniques. The invention is therefore useful in evaluating safety and other health concerns related to the presence of DNA in products resulting from genetic engineering techniques.
    Type: Grant
    Filed: January 24, 1990
    Date of Patent: December 29, 1992
    Assignee: Genomyx, Inc.
    Inventor: Thomas M. Brennan
  • Patent number: 5151244
    Abstract: Water testing apparatus for monitoring circulating water coolant in service within a water cooled nuclear reactor system is disclosed. The invention is an improvement in such water testing apparatus and comprises filtering and a preconditioning of selected sample specimens of the coolant water with a pH adjustment for inhibiting unbalancing an equilibrium in solution of water coolant with ion solutes.
    Type: Grant
    Filed: September 11, 1991
    Date of Patent: September 29, 1992
    Assignee: General Electric Company
    Inventors: Robert J. Law, Michel N. Robles, Dane T. Snyder
  • Patent number: 5098845
    Abstract: A method for conducting immunoassays in an automated fashion is disclosed. A biological fluid under test is placed in a tube (11) which has a solid support (18) therein to which a specific analyte in the biological fluid will be selectively bound. After the analyte in the biological fluid is bound to the solid support (18), the tube (11) is rotated at high speed about its longitudinal axis causing the biological fluid to be transported up the inside walls of tube (11), over the open terminal end (16), and into waste chamber (15). The solid support (18) with the bound analyte may easily be washed byl flushing the inside of tube (11) with water or other suitable fluids and rotating the tube (11) at high speed about its longitudinal axis.
    Type: Grant
    Filed: July 13, 1990
    Date of Patent: March 24, 1992
    Assignee: Cirrus Diagnostics, Inc.
    Inventor: Arthur L. Babson
  • Patent number: 5073484
    Abstract: A method and apparatus for the quantitative determination of an analyte in a liquid employs a liquid-permeable solid medium defining a liquid flow path. The medium includes a number of reaction-containing reaction zones spaced apart along the flow path and in which reaction occurs with the analyte or an analyte derivative (e.g., a labeled analyte) to result in the formation of a predetermined product. Detector means are employed to detect analyte, analyte derivatives, reactant or predetermined product in the reaction zones, the number of such zones in which such detection occurs indicating the amount of analyte in the liquid.
    Type: Grant
    Filed: February 23, 1983
    Date of Patent: December 17, 1991
    Assignee: Bio-Metric Systems, Inc.
    Inventors: Melvin J. Swanson, Patrick E. Guire
  • Patent number: 5055408
    Abstract: An automated immunoassay analyzser comprising a transfer route on which test plates each having a plurality of chambers for immunological reaction opened upwards are transferred continually with a constant interval of time, and devices of at least A, B, C and D described below which are arranged on the transfer route from upstream to downstream in the order referred to in which the device A is for injecting the sample comprising a vertically and horizonally driven support, a pipet fixed to the support, and a nozzle tip usable for a single sample and removably attached to the lower end of the pipet, the device B is for B/F separation and the device C is for injecting the substrate solution and both devices are integratedly combined and comprise a vertically and horizontally driven support, a washing tube supported by the support, a temperature controllable solution reservoir block fixed to the support, a substrate injection tube provided to the lower side of the reservoir block, the washing tube and the substr
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: October 8, 1991
    Assignee: Toyo Soda Manufacturing Co., Ltd.
    Inventors: Yuji Higo, Hidechika Hayashi, Shuji Iwasaki
  • Patent number: 4975378
    Abstract: Method for integrating isotope dilution analysis with chromatography. One embodiment of the invention includes a liquid chromatographic column, a radiochemical detector, an eluent that contains an additive at saturation and a radiochemically labeled derivative of the analyte to be determined. When the analyte, which is not radioactive, is injected, its movement through the column occurs more slowly than the movement of the radioactive derivative situated on the column outside the analyte band. As a result, radioactivity enters the analyte band and isotope dilution occurs. The distribution of radioactivity within the band is used to determine the amount of analyte injected.
    Type: Grant
    Filed: July 26, 1988
    Date of Patent: December 4, 1990
    Inventor: Sujit Banerjee
  • Patent number: 4830830
    Abstract: Nucleic acid fragments labelled by radio isotape migrate at speeds that increase as the molecular weights decrease in a migration path served with a potential at both ends thereof. The migration path is constituted by a pipe-shaped gel support such as a glass tube. A ring-shaped scintillator is provided at a middle portion of the migration path to circumscribe the gel support, and whereby the beta rays are detected. A window may be formed in the glass tube at a portion opposed to the scintillator, so that the beta rays are not attenuated by the glass.
    Type: Grant
    Filed: February 18, 1986
    Date of Patent: May 16, 1989
    Assignee: Hitachi, Ltd.
    Inventors: Simada Tamotu, Hideki Kambara, Yoshinori Harada, Kenichi Watanabe, Jiro Tokita