Sorption Testing Patents (Class 422/69)
  • Patent number: 11119040
    Abstract: A photonic chip has at least one input waveguide, at least one output waveguide, one of at least one Mach-Zehnder interferometer and at least one resonator, and a one-sided optical port enabling in and out coupling of light where the input waveguide begins and the output waveguide ends.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: September 14, 2021
    Inventors: Konstantinos Misiakos, Ioannis Raptis, Alexandros Salapatas
  • Patent number: 11105470
    Abstract: The present invention relates to a method for determining loss of gas in a gas container. According to an embodiment of the present invention, the method for determining the loss of gas in the gas container is characterized by including the steps of (a) filling a first container (10) with a component gas and a balance gas, (b) measuring a gas pressure inside the first gas container (11), (c) allowing the first gas container and a second gas container having an evacuated inside to communicate and performing a first-stage gas pressure split, and (d) measuring a gas pressure inside the second gas container, wherein an amount of the component gas adsorbed inside the gas container is calculated through a difference between a measured value of step (b) and a measured value of step (d) and is determined as an amount of gas loss.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: August 31, 2021
    Assignee: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE
    Inventors: Nam Goo Kang, Sang Hyub Oh
  • Patent number: 10928306
    Abstract: Liquid crystal-based devices for detecting chlorine in a sample and methods of using such devices to detect chlorine are disclosed. Such devices have a substrate surface that includes either metal cations or a metal that is in contact with a composition that includes a liquid crystal. When the device is contacted with a sample that contains chlorine, an observed change in the orientational ordering of the liquid crystal signals the presence of the chlorine. In the absence of chlorine, no change in orientational ordering occurs.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: February 23, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Emmanouil Mavrikakis, Nicholas Abbott, Tibor Szilvasi, Nanqi Bao, Huaizhe Yu
  • Patent number: 10846494
    Abstract: A radio-frequency identification (“RFID”) device includes a substrate and a load formed in the substrate, where the load includes at least one microchannel and at least one body of fusible metal contained within the at least one microchannel. The RFID device also includes an antenna electrically connected to the load, and a protective layer covering at least a portion of the substrate.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: November 24, 2020
    Assignee: The Boeing Company
    Inventors: Joseph Andrew Bolton, Keith Daniel Humfeld
  • Patent number: 10790175
    Abstract: Embodiments include a real time etch rate sensor and methods of for using a real time etch rate sensor. In an embodiment, the real time etch rate sensor includes a resonant system and a conductive housing. The resonant system may include a resonating body, a first electrode formed over a first surface of the resonating body, a second electrode formed over a second surface of the resonating body, and a sacrificial layer formed over the first electrode. In an embodiment, at least a portion of the first electrode is not covered by the sacrificial layer. In an embodiment, the conductive housing may secure the resonant system. Additionally, the conductive housing contacts the first electrode, and at least a portion of an interior edge of the conductive housing may be spaced away from the sacrificial layer.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: September 29, 2020
    Assignee: Applied Materials, Inc.
    Inventors: Philip Allan Kraus, Timothy Joseph Franklin
  • Patent number: 10690809
    Abstract: A metasurface is defined by an array of scattering elements having a U shape, where the geometrical dimensions determining the U shape are determined according to the different phase profiles that the metasurface is meant to generate in response to an incident electromagnetic wave. The metasurface, therefore, generates different phase shifts as a function of the incident electromagnetic wave.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: June 23, 2020
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Seyedeh Mahsa Kamali, Ehsan Arbabi, Amir Arbabi, Yu Horie, MohammadSadegh Faraji-Dana, Andrei Faraon
  • Patent number: 10670489
    Abstract: A method for calibrating a test chamber, which encloses an interior volume (20), is designed as a film chamber (12) comprising at least one flexible wall region (14, 16), and is connected in a gas-conducting way to a pressure sensor (30), to a vacuum pump (26), and via a calibration valve (34) to a calibration chamber (36) enclosing a calibration volume (37), comprising the following steps: evacuating the film chamber (12); measuring the pressure difference inside of the film chamber (12); after the evacuation has been completed, connecting the calibration volume (37) in a gas-conducting manner to the interior volume (20) of the film chamber (12) while measuring the pressure change, wherein the pressure in the calibration chamber (36) is greater than the pressure in the film chamber (12) before the connection to the film chamber (12). A corresponding device is likewise disclosed.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: June 2, 2020
    Assignee: INFICON GmbH
    Inventor: Silvio Decker
  • Patent number: 10661270
    Abstract: Disposable cartridges comprising hinged caps and optical chambers for measuring one or more properties of a blood sample are described. Blood flow in the disposable cartridges may be regulated by either positive or negative pressure. Other embodiments of cartridges comprising a biosensor chamber disposed downstream of the optical chamber are also described. Methods for measuring one or more properties of a blood sample using different cartridge embodiments are provided.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: May 26, 2020
    Assignee: INVIDX CORP.
    Inventor: James Samsoondar
  • Patent number: 10627393
    Abstract: A problem of the present invention is to provide a method capable of avoiding nonspecific reactions which result in the absence of agglutination that should occur in agglutination inhibition LTIA. The present invention provides a method of avoiding nonspecific reactions in a latex agglutination inhibition test by performing a latex agglutination inhibition assay in the presence of one or more compounds selected from the group consisting of polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, and polyvalent quaternary amine polymer compounds.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: April 21, 2020
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Keiko Hattori, Souichi Kitano, Michiko Kawamoto
  • Patent number: 10473580
    Abstract: Apparatus for measuring spectral reflectance of a surface, the apparatus comprising: a chamber comprising a wall formed having an aperture defined by an aperture boundary; a light source mounted to the chamber and having a field of illumination (FOI) configured to intersect the aperture at an illumination intersection; and an optical fiber mounted to the chamber and having a field of view (FOV) configured to intersect the aperture at an imaging intersection; wherein the chamber is configured so that when the aperture is positioned on a surface the chamber substantially prevents light from entering a volume of the chamber.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: November 12, 2019
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Eyal Ben-Dor, Amihai Granot
  • Patent number: 10401344
    Abstract: A system and a method are provided for calculating the cetane number, pour point, cloud point, aniline point, aromaticity, and/or octane number of a crude oil and its fractions from the density and thermogravimetric analysis (TGA) of a sample of the crude oil.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: September 3, 2019
    Assignee: Saudi Arabian Oil Company
    Inventors: Omer Refa Koseoglu, Adnan Al-Hajji, Amer A. Al-Tuwailib
  • Patent number: 10364165
    Abstract: The present invention provides a method for generating hydroxyl radicals and removing organic pollutants in water by utilizing an organic membrane. The inventive method generates hydroxyl radicals by adopting a nitrocellulose membrane as a photocatalytic material, placing the nitrocellulose membrane in water, illuminating with the sun or a sunlamp having a wavelength above 280 nm as a light source, and causing the nitrocellulose membrane to undergo a photochemical reaction at the membrane surface, and the generation rate of hydroxyl radicals can be achieved by adjusting the surface area of the membrane and a light intensity. The generated hydroxyl radicals can remove phenol, bisphenol A, thiamphenicol and other typical organic pollutants in water very well.
    Type: Grant
    Filed: June 25, 2016
    Date of Patent: July 30, 2019
    Assignee: HENAN POLYTECHNIC UNIVERSITY
    Inventors: Chao Tai, Jiaping She, Shao Dong Zhang, Tong Qian Zhao, Dang Yu Song, Lei Feng, Yu Xiang Mao, Yong An Qi, Guo Cheng Zhang, Li Jun Zhang, Juan Wang
  • Patent number: 10345296
    Abstract: A device for identifying the presence of a specific target molecule or biomarker by the detection of a change in an electrical property includes a measurement sensor 8 comprising a semiconducting sensor structure 12 capable of conjugating with the biomarker, thus giving rise to the said change in electrical property, and an electrode system 3, 4 for conducting a signal from the device. According to the invention there is a further such sensor 9, of substantially identical form but having its sensor structure 14 already conjugated with the biomarker, or otherwise capped, e.g. using a further oligonucleotide strand, so as to act as an internal reference. When a biological sample, e.g. saliva, is applied to the electrodes, the reference enables the discounting of all environmental effects other than the biomarker. The invention provides a simple, cheap and accurate test for one or more biomarkers that can be used in the field without complex equipment.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: July 9, 2019
    Assignee: Sapient Sensors Limited
    Inventors: Stephen Lee Cash, Keith Robson, Ian Anthony Kinloch, Peter George Stockley
  • Patent number: 10220385
    Abstract: A method for preparing a plurality of micro-length tubular flow elements for use in a fluid assay, each element having interior and exterior surfaces and having at least one axially-extending flow passage through its interior, includes aggressively agitating the flow elements in a solution of assay capture agent to impart disrupting shear forces on the exterior surface of the elements, the shear forces causing the axially-extending external surfaces of the flow elements to be free of assay capture agent, while at least a portion of the interior surface of the flow elements not experiencing such disruptive shear forces and carrying deposits of the assay capture agent.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: March 5, 2019
    Assignee: CyVek, Inc.
    Inventors: Martin A. Putnam, Jeffrey T. Branciforte, Charles O. Stanwood, Jane M. Tu
  • Patent number: 9778569
    Abstract: A positive photosensitive resin composition according to the present invention contains at least (A) a polysiloxane compound having at least a structural unit of the general formula (1), (B) a photoacid generator or quinone diazide compound and (C) a solvent [(RX)bR1mSiOn/2]??(1) where RX represents the following group; R1 each represents a hydrogen atom, C1-C3 alkyl group, phenyl group, hydroxy group, C1-C3 alkoxy group or C1-C3 fluoroalkyl group; b represents an integer of 1 to 3; m represents an integer of 0 to 2; n represents an integer of 1 to 3; and b, m and n satisfy b+m+n=4, where X each represents a hydrogen atom or acid labile group; and a represents an integer of 1 to 5. It is possible by the use of this positive photosensitive resin composition to provide a film with high resistance and heat-resistant transparency and provide an electronic component with such a film.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: October 3, 2017
    Assignee: Central Glass Company, Limited
    Inventors: Makoto Seino, Kazuhiro Yamanaka, Masafumi Oda, Junya Nakatsuji
  • Patent number: 9778184
    Abstract: With a blood-derived specimen on top of a metal film on a measurement chip, the intensity of reflected excitation light, the resonance angle of excitation light, the intensity of plasmon-scattered light, or the enhancement angle of excitation light is measured, and the acquired measurement is used to obtain a whole-blood hematocrit value. Using the obtained whole-blood hematocrit value, a first signal value that indicates how much of an analyte the specimen contains is converted to a second signal value that indicates how much of said analyte the liquid part of the specimen contains.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: October 3, 2017
    Assignee: KONICA MINOLTA, INC.
    Inventors: Tsuruki Tamura, Makiko Ootani, Youichi Aoki
  • Patent number: 9671558
    Abstract: Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and optically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: June 6, 2017
    Assignee: Intel Corporation
    Inventors: Xing Su, Liming Wang, Jianquan Liu, Kai Wu
  • Patent number: 9645069
    Abstract: An adsorption characteristic measuring apparatus according to the invention supplies a predetermined adsorption gas to a film formed body as a sample accommodated in a sample tube to measure adsorption characteristics. In the inside of the sample tube, a void between an inner wall surface of the sample tube and the sample is filled with a particle-like filler having higher thermal conductivity than the adsorption gas under a measurement pressure. In addition, a glass rod as a dead volume reducing rod, a spacer ring for forming a thermal insulation space between the particle-like filler and the glass rod, and a reflective plate for reflecting radiant heat are disposed.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: May 9, 2017
    Assignees: Waseda University, MicrotracBEL Corp.
    Inventors: Masahiko Matsukata, Kazuyuki Nakai, Masayuki Yoshida
  • Patent number: 9535004
    Abstract: In the present invention, excitation light is irradiated onto an analysis chip that has been placed in a chip holder, reflected light or transmitted light from the analysis chip is detected, and as a result the position information of the analysis chip is obtained. On the basis of this position information, the chip holder is moved by a conveyance stage and thereby moved to a measurement position. Excitation light is irradiated onto the analysis chip that is disposed at the measurement position, and fluorescence emitted from a fluorescent substance that marks the substance to be detected is detected.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: January 3, 2017
    Assignee: Konica Minolta, Inc.
    Inventors: Tetsuya Noda, Masataka Matsuo, Yoshimasa Hamano, Hiroshi Hirayama
  • Patent number: 9448219
    Abstract: One aspect of the invention relates to an ultrathin micro-electromechanical chemical sensing device which uses swelling or straining of a reactive organic material for sensing. In certain embodiments, the device comprises a contact on-off switch chemical sensor. For example, the device can comprises a small gap separating two electrodes, wherein the gap can be closed as a result of the swelling or stressing of an organic polymer coating on one or both sides of the gap. In certain embodiments, the swelling or stressing is due to the organic polymer reacting with a target analyte.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: September 20, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: William Jay Arora, Karen K. Gleason, George Barbastathis, Wyatt E. Tenhaeff
  • Patent number: 9415394
    Abstract: A microfluidic chip (100) with a flow-guiding body (111) and the applications thereof in biochemistry, immunology, and molecule detection. The flow-guiding body (111) is disposed in a solution tank (101) of the microfluidic chip (100), the surface of the flow-guiding body (111) is enclosed by the antigen or antibody, and the gap between the flow-guiding body (111) and a wall (105) of the solution tank is 0 mm to 1.5 mm.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: August 16, 2016
    Assignee: BEIJING BOHUI INNOVATION TECHNOLOGY CO., LTD.
    Inventor: Qi Yang
  • Patent number: 9228974
    Abstract: The present disclosure provides a biological field effect transistor (BioFET) and a method of fabricating a BioFET device. The method includes forming a BioFET using one or more process steps compatible with or typical to a complementary metal-oxide-semiconductor (CMOS) process. The BioFET device includes a plurality of microwells having a bio-sensing layer and a number of stacked well portions over a multi-layer interconnect (MLI). A bottom surface area of a well portion is different from a top surface area of a well portion directly below. The microwells are formed by removing a top metal plate on a topmost level of the MLI.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: January 5, 2016
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Yi-Hsien Chang, Wei-Cheng Shen, Shih-Wei Lin, Chun-Ren Cheng
  • Patent number: 9073053
    Abstract: An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
    Type: Grant
    Filed: September 22, 2005
    Date of Patent: July 7, 2015
    Assignee: Cepheid
    Inventors: Michael T. Taylor, Phillip Belgrader, Farzad Pourahmadi, William A. McMillan, Ronald Chang, Stanley H. Sakai, Jesus Ching
  • Publication number: 20150147804
    Abstract: The present invention relates to a biochemical analysis cartridge having improved operability. More particularly, the present invention provides a biochemical analysis cartridge including an insertion-type sample cartridge and a reaction cartridge receiving the insertion-type sample cartridge, in which,as the sample cartridge is inserted into the reaction cartridge,a reaction solution chamber moves toward a broken part of a covertape so as to automatically supply the reaction solution stored in the chamber. The biochemical analysis cartridge having improved operability according to the present invention can induce the mixing between a sample and a reaction solution by simply inserting them into the reaction cartridge and a reaction thereafter, thereby minimizing the process of a measurer to intervene in the assay, and subsequently improving user convenience and operability.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 28, 2015
    Inventors: Geun Sig CHA, Hakhyun NAM, Dongxuan SHEN, Joo Young CHO, Jihoon KIM
  • Publication number: 20150147818
    Abstract: The present invention relates to a sensor capable of detecting an aromatic nitro compound explosive, and a preparation method thereof, and more specifically, to a nanosensor system, and a detection method using the same, wherein a quantum dot-based sensor for detecting an aromatic nitro compound explosive can conveniently detect an aromatic nitro compound explosive with high sensitivity on the basis of a change in energy transfer between quantum dots. The method for detecting an explosive of the present invention makes an explosive come in contact with a quantum dot thin film to which an explosive can combine, and measures a change in fluorescence wavelength, thereby sensing an explosive.
    Type: Application
    Filed: May 6, 2013
    Publication date: May 28, 2015
    Inventors: Sungjee Kim, Nayoun Won, Jungheon Kwag, Joonhyuck Park, Ho Jin
  • Publication number: 20150148238
    Abstract: The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet microactuator including a droplet including one or more beads and immobilizing at least one of the one or more beads. The method further includes conducting one or more droplet operations to divide the droplet to yield a set of droplets including a droplet including the one or more immobilized beads and a droplet substantially lacking the one or more immobilized beads.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 28, 2015
    Applicants: ADVANCED LIQUID LOGIC, INC., Duke University
    Inventors: Vamsee Pamula, Vijay Srinivasan, Michael G. Pollack, Richard B. Fair
  • Publication number: 20150148661
    Abstract: A system for measuring analyte concentrations has porous-walled nanocontainers containing multiple magnetic nanoparticles, the magnetic nanoparticles coated with a selective binder that is analyte-responsive and binds a the analyte, an indicator substance releasable from the selective binder by the analyte, or an indicator substance cleavable by the analyte, apparatus for exposing the nanocontainers to a fluid potentially containing the analyte, and magnetic spectroscopy of Brownian motion sensing apparatus for detecting agglutination of the nanoparticles or binding of analyte to the nanoparticles.
    Type: Application
    Filed: June 14, 2013
    Publication date: May 28, 2015
    Applicant: The Trustees of Dartmouth College
    Inventors: John B. Weaver, Barjor Gimi, Karl Griswold
  • Publication number: 20150147823
    Abstract: Methods, devices, reagent, systems and kits for the detection, diagnosis of ovarian cancer as well as for the monitoring of ovarian cancer progression and for monitoring the progress of ovarian cancer treatments using BNP as a biomarker.
    Type: Application
    Filed: October 28, 2014
    Publication date: May 28, 2015
    Applicant: Autotelic LLC
    Inventor: Vuong Trieu
  • Publication number: 20150147821
    Abstract: Systems and methods are provided for detecting or measuring binding affinity between different compositions. The methods include contacting one or more magnetic beads having a surface including a first composition with a substrate having a surface including a second composition; applying a rotating magnetic field to the one or more magnetic beads effective to cause the one or more magnetic beads to move across the surface of the substrate; measuring the movement of the one or more magnetic beads across the substrate surface to determine a translational velocity; and determining a binding affinity between the first and second compositions from the translational velocity.
    Type: Application
    Filed: May 15, 2013
    Publication date: May 28, 2015
    Applicant: Massachusetts Instiute of Technology
    Inventors: Charles E. Sing, Joshua P. Steimel, Alfredo Alexander-Katz
  • Publication number: 20150140582
    Abstract: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g. an enzyme, fluorescent or direct label etc.) wherein said conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e. which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
    Type: Application
    Filed: December 29, 2014
    Publication date: May 21, 2015
    Inventor: Juergen Klepp
  • Publication number: 20150140552
    Abstract: The present invention related to a quantitative assay device and a method for the determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid connection with the test membrane and a porous downstream membrane in fluid connection with the test membrane, wherein the test membrane contains two bands having deposited on there high and low concentrations of different calibrator agents and a test band capable of reacting with conjugated analyte complexes giving rise to a measurable signal.
    Type: Application
    Filed: November 13, 2014
    Publication date: May 21, 2015
    Inventor: Jin Po LEE
  • Publication number: 20150139857
    Abstract: A biochip includes a substrate, where the substrate includes at least one hole extending from a first surface of the substrate to a second surface of the substrate opposite the first surface, and where the substrate comprises a microfluidic channel pattern. The biochip further includes a surface modification layer over the substrate. Additionally, the biochip includes a sensing wafer bonded to the substrate, where the sensing wafer has one or more modified surface patterns having different surface properties from each other.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 21, 2015
    Inventors: Yi-Shao LIU, Chun-Wen CHENG, Chun-Ren CHENG
  • Publication number: 20150139856
    Abstract: The optical device has a substrate having a dielectric body on a surface, a metal fine structure formed of a plurality of metal nanostructures formed on the dielectric body, and an organic molecular film formed on the dielectric body between the plurality of metal nanostructures, and adapted to capture target molecule. The plurality of metal nanostructures each has a diameter in a planar view of 1 through 500 nm, and has a distance between the metal nanostructures adjacent to each other of no smaller than 0.1 nm and smaller than 10 nm. The plurality of metal nanostructures has the distance between the metal nanostructures adjacent to each other at a second height position H2 from the surface of the dielectric body larger than a first distance between the metal nanostructures adjacent to each other at a first height position H1 (H2>H1) from the surface of the dielectric body.
    Type: Application
    Filed: April 23, 2013
    Publication date: May 21, 2015
    Inventors: Akiko Yamada, Kohei Yamada
  • Publication number: 20150140556
    Abstract: The present invention provides, in addition to other things, methods, systems, and apparatuses that involve the use of an optical fiber with grating and particulate coating that enables simultaneous heating; optical detection; and optionally temperature measurement. Methods, systems, and apparatuses of the present invention may be used in many applications including isothermal and/or thermal cycling reactions. In certain embodiments, the present invention provides methods, systems, and apparatuses for use in detecting, quantifying and/or identifying one or more known or unknown analytes in a sample.
    Type: Application
    Filed: June 20, 2013
    Publication date: May 21, 2015
    Inventors: Jacques Albert, Anatoli Ianoul, Aliaksandr Bialiayeu, Adam Bottomley
  • Publication number: 20150132186
    Abstract: Provided is a microanalysis method and system using a Field Effect Transistor (FET). The microanalysis method includes a channel region having a receptor molecule fixed; forming a nano-particle conjugate in the channel region by supplying a sample for test and the nano-particle conjugate to the FET; growing a probe material on the channel region; and measuring a current flowing through the channel region, wherein the receptor molecule is a material that is selectively bonded to a target molecule in the sample for test.
    Type: Application
    Filed: January 20, 2015
    Publication date: May 14, 2015
    Inventors: Chil Seong AH, Jong-Heon YANG, Chan Woo PARK, Chang-Geun AHN, Gun Yong SUNG
  • Publication number: 20150132835
    Abstract: The present disclosure relates to devices, systems, and methods for performing diagnostic tests. The disclosed diagnostic devices are capable of performing analytic tests and communicating with a portable multifunctional device (PMD) or other computing device. Through input and manipulation of materials within the diagnostic device, a large range of tests may be performed. For example, alteration or customization of chemical components of the diagnostic device may enable many analytic applications to be provided. These analytic tests may include, but are not limited to, sensing or quantification of chemicals from sample input, whether gaseous, liquid, or otherwise, sensing or quantification of analytes, antibodies, or antigens, sensing or quantification of genetic material, or other substances.
    Type: Application
    Filed: July 2, 2013
    Publication date: May 14, 2015
    Inventors: William Robert Pagels, Andrew David Pagels, Christopher William Pagels
  • Patent number: 9029092
    Abstract: Methods, reagents, kits and systems are disclosed for determining an analyte in a sample suspected of containing the analyte where all reagents are soluble in aqueous solution. One assay method includes treating a sample suspected of containing the analyte under conditions such that if the analyte is present, an activator is brought into reactive configuration with a chemiluminescent compound to activates it. The sample is also treated with an agent to reduce signal not related to analyte. Finally, the sample is treated with a trigger solution thereby producing light from the activated chemiluminescent compound. No reagents are associated with a surface or other solid phase.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: May 12, 2015
    Assignee: Beckman Coulter, Inc.
    Inventors: Hashem Akhavan-Tafti, Dean G. Binger, Ying Chen, Renuka De Silva, Terri McLernon, James Mendoza, Bruce H. Odegaard, Michael Salvati, Nir Shapir, Wenhua Xie
  • Patent number: 9028771
    Abstract: The invention provides a modified form of saturation assay, which is based on the measurement of a free or unbound labelled reagent fraction (such that there is an increase in signal in the presence of analyte) and employs trapping zones to concentrate said unbound or free labelled fraction to avoid loss of sensitivity. Preferably, the assay is a membrane assay.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: May 12, 2015
    Assignee: Platform Diagnostics Limited
    Inventors: Douglas Robert Evans, Gerald John Allen, Carolyn Jennifer Ruddell
  • Patent number: 9029162
    Abstract: Disclosed are methods and systems for the analysis of testosterone in a sample using supported liquid extraction and liquid chromatography-mass spectrometry.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: May 12, 2015
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Russell Philip Grant, Matthew Crawford, Donald Walt Chandler, William Curtin
  • Publication number: 20150125346
    Abstract: Embodiments of the present invention are directed toward devices, systems, and method for conducting assays using sedimentation. In one example, a method includes layering a mixture on a density medium, subjecting sedimentation particles in the mixture to sedimentation forces to cause the sedimentation particles to move to a detection area through a density medium, and detecting a target analyte in a detection region of the sedimentation channel. In some examples, the sedimentation particles and labeling agent may have like charges to reduce non-specific binding of labeling agent and sedimentation particles. In some examples, the density medium is provided with a separation layer for stabilizing the assay during storage and operation. In some examples, the sedimentation channel may be provided with a generally flat sedimentation chamber for dispersing the particle pellet over a larger surface area.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 7, 2015
    Inventors: Ulrich Y. Schaff, Chung-Yan Koh, Gregory J. Sommer
  • Publication number: 20150125873
    Abstract: According to the invention there is provided a method of detecting an analyte including the steps of: i) providing a sample which contains the analyte and magnetic nanoparticles, in which the magnetic nanoparticles include a magnetic body portion which acts as a signalling vector and at least one receptor moiety attached to the body portion for binding to the analyte; ii) applying a magnetic field across at least a portion of the sample to orient the magnetic nanoparticles with respect to the applied magnetic field; iii) introducing electromagnetic radiation into the sample; iv) detecting a physical property which varies in dependence on the orientation of the magnetic nanoparticles with respect to the applied magnetic field, wherein the physical property is associated with the interaction of the electromagnetic radiation with the magnetic body portion which thereby acts as a signalling vector; and v) correlating the detected physical property with the presence of the analyte.
    Type: Application
    Filed: September 3, 2012
    Publication date: May 7, 2015
    Inventors: David Newman, Raphael Matelon
  • Publication number: 20150125872
    Abstract: The present disclosure provides a device, such as a FET sensing cell, which includes a first dielectric layer over a substrate, an active layer over the first dielectric layer, a source region in the active layer, a drain region in the active layer, a channel region in the active layer situated between the source region and the drain region, a sensing film over the channel region, a second dielectric layer over the active layer, wherein an opening is formed in the second dielectric layer and the sensing film is located within the opening, a first electrode located within the second dielectric layer and a fluidic gate region located over the second dielectric layer and extending into the opening. The present disclosure also provides a method for improving the sensitivity of a device by adjusting a sensing value.
    Type: Application
    Filed: November 1, 2013
    Publication date: May 7, 2015
    Applicant: Taiwan Semiconductor Manufacturing Company Limited
    Inventors: Tung-Tsun Chen, Jui-Cheng Huang, Chin-Hua Wen, Chun-wen Cheng, Yi-Shao Liu
  • Publication number: 20150125882
    Abstract: The present disclosure provides methods and systems for assaying a sample. A microfluidic device to perform an assay of a sample (e.g., biological sample) is described having a sample application site, a porous component and a flow channel. The porous component provides for uniform dissolution of a reagent and mixing of the sample and reagent without filtering the sample.
    Type: Application
    Filed: November 5, 2014
    Publication date: May 7, 2015
    Inventors: Scott Joseph Bornheimer, Jeffrey Sugarman, Wei Huang, Edward Michael Goldberg, Ming Tan
  • Publication number: 20150126633
    Abstract: The present invention relates to a method for fabricating a three-dimensional porous fibrous microstructure, various three-dimensional porous fibrous microstructures fabricated by the method, an apparatus for detecting a biological marker and a drug delivery system comprising the microstructure. The porous fibrous microstructure of the present invention has excellent interconnectivity between pores and micropores and captures and delivers target particles at high efficiency, and thus can be usefully applied to biomedical applications including the detection of a biomarker and drug delivery.
    Type: Application
    Filed: November 3, 2014
    Publication date: May 7, 2015
    Inventors: Hyung Il JUNG, Cheng Guo LI
  • Publication number: 20150125938
    Abstract: An liquid sample measuring system includes a measuring device including a measuring section which measures biological information from liquid sample of a living subject within a housing in which a biosensor, on which the liquid sample of the biological body is deposited, is detachably mounted and a movement measuring section which measures movement information of the housing within the housing, and an administrating device including a movement determining section which determines whether or not a degree of the movement of the housing is within an allowable range by analyzing the movement information received from the measuring device.
    Type: Application
    Filed: December 26, 2012
    Publication date: May 7, 2015
    Applicant: Panasonic Healthcare Co., Ltd.
    Inventors: Noriyoshi Terashima, Teppei Shinno, Masataka Nadaoka, Yoshimasa Oda
  • Publication number: 20150125965
    Abstract: Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
    Type: Application
    Filed: January 12, 2015
    Publication date: May 7, 2015
    Inventors: Yuegang Zhang, Andrew Berlin, Qing Ma, Li-Peng Wang, Valluri Rao, Mineo Yamakawa
  • Publication number: 20150126388
    Abstract: A surface enhanced Raman spectroscopy (SERS) marker conjugate is provided. The SERS marker conjugate comprises a metallic nanoparticle and an organometallic material attached to a surface of the metallic nanoparticle. A biosensor comprising a plurality of the SERS marker conjugates and a method of forming the SERS marker conjugate is also provided.
    Type: Application
    Filed: May 28, 2013
    Publication date: May 7, 2015
    Applicant: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Kien Voon Kong, Malini Olivo, Weng Kee Leong, Zhiyong Lam
  • Publication number: 20150118690
    Abstract: A sample analyzer has an illuminator for illuminating an assay sample to cause luminescence, and a support for a sample vessel containing the assay sample. The support is adapted to position the assay sample proximate the illuminator. A detector is positioned along an optical axis extending from the illuminator, through the positioned assay sample, to the detector, so as to detect the luminescence from the assay sample. A reflector is removably disposed between the illuminator and the assay sample so as to reflect a portion of the luminescence back through the positioned assay sample toward the detector.
    Type: Application
    Filed: April 23, 2013
    Publication date: April 30, 2015
    Applicant: Siemens Healthcare Diagnostic Inc.
    Inventors: Jeffrey R. Jasperse, Normand P. Desmarais
  • Publication number: 20150119263
    Abstract: Disclosed are devices that comprise a protein, such as an antibody, placed into electronic communication with a semiconductor material, such as a carbon nanotube. The devices are useful in assessing the presence or concentration of analytes contacted to the devices, including the presence of markers for prostate cancer and Lyme disease.
    Type: Application
    Filed: August 30, 2012
    Publication date: April 30, 2015
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, FOX CHASE CANCER CENTER
    Inventors: Alan T. Johnson, JR., Mitchell Lerner, Matthew K. Robinson, Tatiana Pazina, Dustin Brisson, Jennifer Dailey
  • Publication number: 20150119270
    Abstract: The present invention discloses, inter alia, methods for labeling a target protein with an SHG-active probe for detection by second harmonic or sum-frequency generation in order to identify agents which bind to an allosteric site on the target protein thereby altering its structural conformation
    Type: Application
    Filed: April 25, 2013
    Publication date: April 30, 2015
    Inventor: Joshua S. Salafsky