Sorption Testing Patents (Class 422/69)
  • Patent number: 11679561
    Abstract: According to some aspects, techniques are provided for identifying contamination in additive fabrication devices by measuring light interacting with the contamination using one or more light sensors. Contamination located between a light source and a target of a light source can affect the uniformity and intensity of the light source when incident upon the target. For instance, in an inverse stereolithography device, contamination located between a light source and a liquid photopolymer resin that is to be cured can affect the quality of the fabricated object when the light is scattered or blocked by the contamination. Identifying the presence of contamination between the light source and the liquid photopolymer resin and alerting the user prior to initiating a fabrication process may increase the quality of the resulting fabricated object and improve the user experience by saving time and photocurable liquid.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: June 20, 2023
    Assignee: Formlabs, Inc.
    Inventors: Shane Wighton, Andrew M. Goldman, Henry Whitney, Justin Keenan
  • Patent number: 11680946
    Abstract: The present invention relates to methods of conducting cholinesterase inhibition assays. In one instance, the assays can be configured to determine the presence of inactivated and activated cholinesterases. Also described herein are microfluidic devices and systems for conducting such assays.
    Type: Grant
    Filed: January 7, 2021
    Date of Patent: June 20, 2023
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Chung-Yan Koh, Robert Meagher, Tyler Phillips Eckles
  • Patent number: 11673134
    Abstract: Provided herein are devices that facilitate the magnetic separation of an analyte from a sample, and methods of use thereof. In particular embodiments, devices and methods are provided for the trans-interfacial magnetic separation (TIMS) of analytes from a sample.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: June 13, 2023
    Assignee: Northwestern University
    Inventors: David M. Kelso, Abhishek K. Agarwal, Sally M. McFall, Tom Westberg, Matthew Austin Butzler, Jennifer L. Reed
  • Patent number: 11661469
    Abstract: Disclosed is a method of preparing polymer film-metal composites and uses of such composites. The metal can be in the form of a nanoparticle or a film. The methods comprise depositing on a surface, a composition comprising: a cationic metal precursor; a polymer film precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite on the surface.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: May 30, 2023
    Assignee: National Research Council of Canada
    Inventors: Lidija Malic, Xuefeng Zhang, Keith Morton, Teodor Veres
  • Patent number: 11654429
    Abstract: A sample carrier may include a sample preparation module and an amplification module. A sample mixes with a lysis medium and a nucleic acid amplification medium in the sample preparation module and then flows into a plurality of microfluidic chambers in the amplification module. The microfluidic chambers have disposed therein primers configured to initiate amplification of one or more target nucleic acid sequences corresponding to one or more pathogens. The sample carrier is inserted into an apparatus that includes a plurality of Sight sources and a camera. The light sources illuminate the microfluidic chambers with excitation light, a fluorophore emits fluorescence light indicative of nucleic acid amplification in response to the excitation-light, and the camera captures images of the microfluidic chambers. A target nucleic acid sequence in the sample is indicated by the images showing an increasing fluorescence in a microfluidic chamber that has the primers for that sequence.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: May 23, 2023
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Brian T. Cunningham, Rashid Bashir, Anurup Ganguli, Akid Ornob, Gregory Damhorst, Hojeong Yu, Weili Chen, Fu Sun
  • Patent number: 11644456
    Abstract: A rapid testing mechanism for respiratory viral pathogens includes a filter material positioned to capture exhaled breath particles from a respiratory tract. A portion of the filter material is impregnated with a pathogen binding adsorptive reagent. When the exhaled breath particles pass through the filter material the following occurs: when the binding adsorptive reagent reacts, a positive test for respiratory viral pathogens is indicated by the filter material; and when pathogen binding adsorptive reagent does not react, a negative test for respiratory viral pathogens is indicated by the filter material.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: May 9, 2023
    Inventors: Brandon Heeger, Ajay Lajmi
  • Patent number: 11632450
    Abstract: An electronic device, method and computer program product provide an image capturing device having a lens assembly including a lens and lens housing that supports the lens. The lens housing has an opening that exposes the lens. A planar exterior surface of the electronic device extends across the lens assembly and includes a slit aperture that is smaller than the opening in the lens housing of the image capturing device. The slit aperture directs only a corresponding portion of light from in front of the planar exterior surface through the opening to the lens. The slit aperture enables at least one of: (i) reducing noticeability of the image capturing device; and (ii) use of an adjacent portion of the planar exterior surface for an aesthetic or functional component. An image from the image capturing device is sharpened along a longer dimension of the slit aperture to remove asymmetric blur.
    Type: Grant
    Filed: February 22, 2022
    Date of Patent: April 18, 2023
    Assignee: Motorola Mobility LLC
    Inventors: Cole P Sheldon, Zetong Gu, John Pincenti, Emily Yang
  • Patent number: 11567069
    Abstract: One non-limiting and exemplary embodiment provides a metal microscopic structure capable of detecting a low-concentration analyte with high sensitivity. The metal microscopic structure includes a base member including multiple protrusions arrayed at predetermined intervals, and multiple projections made of a metal film covering the base member and configured to generate surface plasmons upon irradiation with light. A film thickness of the metal film positioned in a bottom portion of a gap between every adjacent two of the multiple projections is greater than a height of the multiple protrusions and is more than or equal to 90% and less than or equal to 100% of a film thickness of the metal film deposited on top portions of the multiple protrusions.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: January 31, 2023
    Inventors: Takashi Kanno, Hiroto Yanagawa
  • Patent number: 11543429
    Abstract: Disclosed is a method for preparing nanoscale electrodes comprised of electrochemically grown noble metal nanowires, and use of the same for the detection of extremely small concentrations of molecules. Such nanoscale electrodes provide target molecule release information from submicron areas on the cell surface, significantly increasing the spatial resolution of the target molecule mapping of a cell surface to enable localization of target molecules on the cell surface, which can be critical for the detection of certain cells with different properties in a given group of cells, such as circulating tumor cells.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: January 3, 2023
    Assignee: Morgan State University
    Inventors: Birol Ozturk, Alperen Guver, Peker Milas
  • Patent number: 11511244
    Abstract: A fluidic device for capturing or detecting a sample substance contained in a solution includes at least two continuous circulation flow channels selected from the group consisting of: a first type continuous circulation flow channel which is formed of a first circulation flow channel and a second circulation flow channel and which is configured to circulate the solution in the first circulation flow channel and then circulate the solution in the second circulation flow channel; and a second type continuous circulation flow channel which is formed of a third circulation flow channel and a fourth circulation flow channel and which is configured to circulate the solution in the third circulation flow channel and then circulate and mix the solution in both of the third and fourth circulation flow channels, wherein any one of the circulation flow channels has a capturing section which captures the sample substance, and/or a detecting section which detects the sample substance.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: November 29, 2022
    Inventors: Keiji Mitsui, Ryo Kobayashi
  • Patent number: 11435371
    Abstract: The present invention relates to a device (100) for isolating an analyte (2) from a body fluid sample (4), wherein the analyte (2) is part of a target (6) contained in the body fluid sample (4). The device (100) comprises at least two types of magnetic particles (8, 12) for binding the analyte (2) and/or the target (6), at least three chambers (16, 18, 20) arranged in series to allow controlled movement of the magnetic particles (8, 12) and at least one fluid for releasing the analyte (2) from the target (6).
    Type: Grant
    Filed: November 23, 2017
    Date of Patent: September 6, 2022
    Assignee: Siemens Healthineers Nederland B.V.
    Inventors: Harma Martine Feitsma, Vanda Lucia De Carvalho Vittorino De Almeida, Christianne Rossette Maria De Witz, Matthias Irmscher, Sandra Martina Van Den Bosch
  • Patent number: 11397141
    Abstract: The present disclosure relates to a method for diluting a sample liquid taken from a sampling point for the subsequent determination of a parameter which depends on a concentration of at least one analyte in the sample liquid, including: supplying a first quantity of the sample liquid to a mixing device via a first sample liquid line; supplying a second quantity of the sample liquid to a separator via a second sample liquid line; separating the analyte from the second quantity of the sample liquid supplied to the separator by means of the separator to obtain a dilution liquid that no longer contains the analyte, and mixing at least one portion of the first quantity of the sample liquid supplied to the mixing device via the first sample liquid line with at least one portion of the dilution liquid by means of the mixing device.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: July 26, 2022
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventors: Ulrich Kathe, Ulrich Rottensteiner, Daniel Schweitzer
  • Patent number: 11366055
    Abstract: A method of spectroscopically assessing the chemical composition of a bubble while the bubble constrains a gas within the interior of the bubble by passing light passing through the bubble and comparing properties of the light before and after the light has passed through the bubble. The bubble is located, preferably compressed between a first plate and a second plate providing a compressed bubble with relatively flat first polar end wall portion adjacent the first plate in a relatively flat second polar end wall portion adjacent a second plate and directing the light to pass through the bubble via the first and second polar end wall portions.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: June 21, 2022
    Assignee: OP-Hygiene IP GmbH
    Inventor: Heiner Ophardt
  • Patent number: 11340241
    Abstract: An automated analyzer capable of continuously performing supply of consumables is realized while continuing measurement is performed, by a simple and small amount of mechanism. An automated analyzer includes a unit that executes processing necessary for sample analysis; a consumable supply unit that supplies consumables necessary for the sample analysis to the unit; and a control device that controls operations of the unit and the consumable supply unit, in which the consumable supply unit includes a consumable container holding portion that holds a consumable storage container in which consumables is aligned and accommodated, a preliminary storage portion that temporarily holds the consumables taken out from the consumable storage container, and a transport mechanism that transports the consumables to the unit, and in which the control device transports and stores at least a portion of the consumables taken out from the consumable storage container in the preliminary storage portion.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: May 24, 2022
    Inventors: Shunsuke Sasaki, Takenori Okusa, Yoshihiro Yamashita, Hiroki Fujita, Kenta Imai, Toshiharu Suzuki
  • Patent number: 11235329
    Abstract: The present disclosure is directed to methods and systems for detecting a substance of interest. The methods and systems include collecting the substance of interest on a collection device comprising an inert fiber material and a siloxane resin. The systems and methods further include heating the collection device in a desorber, wherein heating the device releases the substance of interest from the device, performing an analysis of the substance of interest, and detecting the substance of interest.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: February 1, 2022
    Assignee: Rapiscan Systems, Inc.
    Inventors: Matthew Meketa, Hanh Lai, Tracy Lynn Paxon, Bing Li
  • Patent number: 11209418
    Abstract: The present invention provides a vapor-permeable flexible sensing platform unit comprising: a first porous membrane, wherein said membrane is substantially flexible and hydrophobic; and a volatile organic compounds (VOCs) sensor disposed on said membrane, the VOCs sensor comprising an electrode array and a conducting polymer porous film being in electric contact with said electrode array, wherein the VOCs sensor is insensitive to lateral strain. Further provided are a method of preparation of said platform unit and a lift-off, float-on (LOFO) method for the preparation of protonically doped polyaniline (PANI) thin films.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: December 28, 2021
    Inventors: Hossam Haick, Weiwei Wu
  • Patent number: 11195086
    Abstract: Techniques are disclosed for fabricating and using a neuromorphic computing device including biological neurons. For example, a method for fabricating a neuromorphic computing device includes forming a channel in a first substrate and forming at least one sensor in a second substrate. At least a portion of the channel in the first substrate is seeded with a biological neuron growth material. The second substrate is attached to the first substrate such that the at least one sensor is proximate to the biological neuron growth material and growth of the seeded biological neuron growth material is stimulated to grow a neuron in the at least a portion of the channel.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: December 7, 2021
    Assignee: International Business Machines Corporation
    Inventors: Steven J. Holmes, Devendra K. Sadana, Stephen W. Bedell, Teodor K. Todorov
  • Patent number: 11119040
    Abstract: A photonic chip has at least one input waveguide, at least one output waveguide, one of at least one Mach-Zehnder interferometer and at least one resonator, and a one-sided optical port enabling in and out coupling of light where the input waveguide begins and the output waveguide ends.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: September 14, 2021
    Inventors: Konstantinos Misiakos, Ioannis Raptis, Alexandros Salapatas
  • Patent number: 11105470
    Abstract: The present invention relates to a method for determining loss of gas in a gas container. According to an embodiment of the present invention, the method for determining the loss of gas in the gas container is characterized by including the steps of (a) filling a first container (10) with a component gas and a balance gas, (b) measuring a gas pressure inside the first gas container (11), (c) allowing the first gas container and a second gas container having an evacuated inside to communicate and performing a first-stage gas pressure split, and (d) measuring a gas pressure inside the second gas container, wherein an amount of the component gas adsorbed inside the gas container is calculated through a difference between a measured value of step (b) and a measured value of step (d) and is determined as an amount of gas loss.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: August 31, 2021
    Inventors: Nam Goo Kang, Sang Hyub Oh
  • Patent number: 10928306
    Abstract: Liquid crystal-based devices for detecting chlorine in a sample and methods of using such devices to detect chlorine are disclosed. Such devices have a substrate surface that includes either metal cations or a metal that is in contact with a composition that includes a liquid crystal. When the device is contacted with a sample that contains chlorine, an observed change in the orientational ordering of the liquid crystal signals the presence of the chlorine. In the absence of chlorine, no change in orientational ordering occurs.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: February 23, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Emmanouil Mavrikakis, Nicholas Abbott, Tibor Szilvasi, Nanqi Bao, Huaizhe Yu
  • Patent number: 10846494
    Abstract: A radio-frequency identification (“RFID”) device includes a substrate and a load formed in the substrate, where the load includes at least one microchannel and at least one body of fusible metal contained within the at least one microchannel. The RFID device also includes an antenna electrically connected to the load, and a protective layer covering at least a portion of the substrate.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: November 24, 2020
    Assignee: The Boeing Company
    Inventors: Joseph Andrew Bolton, Keith Daniel Humfeld
  • Patent number: 10790175
    Abstract: Embodiments include a real time etch rate sensor and methods of for using a real time etch rate sensor. In an embodiment, the real time etch rate sensor includes a resonant system and a conductive housing. The resonant system may include a resonating body, a first electrode formed over a first surface of the resonating body, a second electrode formed over a second surface of the resonating body, and a sacrificial layer formed over the first electrode. In an embodiment, at least a portion of the first electrode is not covered by the sacrificial layer. In an embodiment, the conductive housing may secure the resonant system. Additionally, the conductive housing contacts the first electrode, and at least a portion of an interior edge of the conductive housing may be spaced away from the sacrificial layer.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: September 29, 2020
    Assignee: Applied Materials, Inc.
    Inventors: Philip Allan Kraus, Timothy Joseph Franklin
  • Patent number: 10690809
    Abstract: A metasurface is defined by an array of scattering elements having a U shape, where the geometrical dimensions determining the U shape are determined according to the different phase profiles that the metasurface is meant to generate in response to an incident electromagnetic wave. The metasurface, therefore, generates different phase shifts as a function of the incident electromagnetic wave.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: June 23, 2020
    Inventors: Seyedeh Mahsa Kamali, Ehsan Arbabi, Amir Arbabi, Yu Horie, MohammadSadegh Faraji-Dana, Andrei Faraon
  • Patent number: 10670489
    Abstract: A method for calibrating a test chamber, which encloses an interior volume (20), is designed as a film chamber (12) comprising at least one flexible wall region (14, 16), and is connected in a gas-conducting way to a pressure sensor (30), to a vacuum pump (26), and via a calibration valve (34) to a calibration chamber (36) enclosing a calibration volume (37), comprising the following steps: evacuating the film chamber (12); measuring the pressure difference inside of the film chamber (12); after the evacuation has been completed, connecting the calibration volume (37) in a gas-conducting manner to the interior volume (20) of the film chamber (12) while measuring the pressure change, wherein the pressure in the calibration chamber (36) is greater than the pressure in the film chamber (12) before the connection to the film chamber (12). A corresponding device is likewise disclosed.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: June 2, 2020
    Assignee: INFICON GmbH
    Inventor: Silvio Decker
  • Patent number: 10661270
    Abstract: Disposable cartridges comprising hinged caps and optical chambers for measuring one or more properties of a blood sample are described. Blood flow in the disposable cartridges may be regulated by either positive or negative pressure. Other embodiments of cartridges comprising a biosensor chamber disposed downstream of the optical chamber are also described. Methods for measuring one or more properties of a blood sample using different cartridge embodiments are provided.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: May 26, 2020
    Assignee: INVIDX CORP.
    Inventor: James Samsoondar
  • Patent number: 10627393
    Abstract: A problem of the present invention is to provide a method capable of avoiding nonspecific reactions which result in the absence of agglutination that should occur in agglutination inhibition LTIA. The present invention provides a method of avoiding nonspecific reactions in a latex agglutination inhibition test by performing a latex agglutination inhibition assay in the presence of one or more compounds selected from the group consisting of polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, and polyvalent quaternary amine polymer compounds.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: April 21, 2020
    Inventors: Keiko Hattori, Souichi Kitano, Michiko Kawamoto
  • Patent number: 10473580
    Abstract: Apparatus for measuring spectral reflectance of a surface, the apparatus comprising: a chamber comprising a wall formed having an aperture defined by an aperture boundary; a light source mounted to the chamber and having a field of illumination (FOI) configured to intersect the aperture at an illumination intersection; and an optical fiber mounted to the chamber and having a field of view (FOV) configured to intersect the aperture at an imaging intersection; wherein the chamber is configured so that when the aperture is positioned on a surface the chamber substantially prevents light from entering a volume of the chamber.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: November 12, 2019
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Eyal Ben-Dor, Amihai Granot
  • Patent number: 10401344
    Abstract: A system and a method are provided for calculating the cetane number, pour point, cloud point, aniline point, aromaticity, and/or octane number of a crude oil and its fractions from the density and thermogravimetric analysis (TGA) of a sample of the crude oil.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: September 3, 2019
    Assignee: Saudi Arabian Oil Company
    Inventors: Omer Refa Koseoglu, Adnan Al-Hajji, Amer A. Al-Tuwailib
  • Patent number: 10364165
    Abstract: The present invention provides a method for generating hydroxyl radicals and removing organic pollutants in water by utilizing an organic membrane. The inventive method generates hydroxyl radicals by adopting a nitrocellulose membrane as a photocatalytic material, placing the nitrocellulose membrane in water, illuminating with the sun or a sunlamp having a wavelength above 280 nm as a light source, and causing the nitrocellulose membrane to undergo a photochemical reaction at the membrane surface, and the generation rate of hydroxyl radicals can be achieved by adjusting the surface area of the membrane and a light intensity. The generated hydroxyl radicals can remove phenol, bisphenol A, thiamphenicol and other typical organic pollutants in water very well.
    Type: Grant
    Filed: June 25, 2016
    Date of Patent: July 30, 2019
    Inventors: Chao Tai, Jiaping She, Shao Dong Zhang, Tong Qian Zhao, Dang Yu Song, Lei Feng, Yu Xiang Mao, Yong An Qi, Guo Cheng Zhang, Li Jun Zhang, Juan Wang
  • Patent number: 10345296
    Abstract: A device for identifying the presence of a specific target molecule or biomarker by the detection of a change in an electrical property includes a measurement sensor 8 comprising a semiconducting sensor structure 12 capable of conjugating with the biomarker, thus giving rise to the said change in electrical property, and an electrode system 3, 4 for conducting a signal from the device. According to the invention there is a further such sensor 9, of substantially identical form but having its sensor structure 14 already conjugated with the biomarker, or otherwise capped, e.g. using a further oligonucleotide strand, so as to act as an internal reference. When a biological sample, e.g. saliva, is applied to the electrodes, the reference enables the discounting of all environmental effects other than the biomarker. The invention provides a simple, cheap and accurate test for one or more biomarkers that can be used in the field without complex equipment.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: July 9, 2019
    Assignee: Sapient Sensors Limited
    Inventors: Stephen Lee Cash, Keith Robson, Ian Anthony Kinloch, Peter George Stockley
  • Patent number: 10220385
    Abstract: A method for preparing a plurality of micro-length tubular flow elements for use in a fluid assay, each element having interior and exterior surfaces and having at least one axially-extending flow passage through its interior, includes aggressively agitating the flow elements in a solution of assay capture agent to impart disrupting shear forces on the exterior surface of the elements, the shear forces causing the axially-extending external surfaces of the flow elements to be free of assay capture agent, while at least a portion of the interior surface of the flow elements not experiencing such disruptive shear forces and carrying deposits of the assay capture agent.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: March 5, 2019
    Assignee: CyVek, Inc.
    Inventors: Martin A. Putnam, Jeffrey T. Branciforte, Charles O. Stanwood, Jane M. Tu
  • Patent number: 9778569
    Abstract: A positive photosensitive resin composition according to the present invention contains at least (A) a polysiloxane compound having at least a structural unit of the general formula (1), (B) a photoacid generator or quinone diazide compound and (C) a solvent [(RX)bR1mSiOn/2]??(1) where RX represents the following group; R1 each represents a hydrogen atom, C1-C3 alkyl group, phenyl group, hydroxy group, C1-C3 alkoxy group or C1-C3 fluoroalkyl group; b represents an integer of 1 to 3; m represents an integer of 0 to 2; n represents an integer of 1 to 3; and b, m and n satisfy b+m+n=4, where X each represents a hydrogen atom or acid labile group; and a represents an integer of 1 to 5. It is possible by the use of this positive photosensitive resin composition to provide a film with high resistance and heat-resistant transparency and provide an electronic component with such a film.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: October 3, 2017
    Assignee: Central Glass Company, Limited
    Inventors: Makoto Seino, Kazuhiro Yamanaka, Masafumi Oda, Junya Nakatsuji
  • Patent number: 9778184
    Abstract: With a blood-derived specimen on top of a metal film on a measurement chip, the intensity of reflected excitation light, the resonance angle of excitation light, the intensity of plasmon-scattered light, or the enhancement angle of excitation light is measured, and the acquired measurement is used to obtain a whole-blood hematocrit value. Using the obtained whole-blood hematocrit value, a first signal value that indicates how much of an analyte the specimen contains is converted to a second signal value that indicates how much of said analyte the liquid part of the specimen contains.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: October 3, 2017
    Assignee: KONICA MINOLTA, INC.
    Inventors: Tsuruki Tamura, Makiko Ootani, Youichi Aoki
  • Patent number: 9671558
    Abstract: Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and optically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: June 6, 2017
    Assignee: Intel Corporation
    Inventors: Xing Su, Liming Wang, Jianquan Liu, Kai Wu
  • Patent number: 9645069
    Abstract: An adsorption characteristic measuring apparatus according to the invention supplies a predetermined adsorption gas to a film formed body as a sample accommodated in a sample tube to measure adsorption characteristics. In the inside of the sample tube, a void between an inner wall surface of the sample tube and the sample is filled with a particle-like filler having higher thermal conductivity than the adsorption gas under a measurement pressure. In addition, a glass rod as a dead volume reducing rod, a spacer ring for forming a thermal insulation space between the particle-like filler and the glass rod, and a reflective plate for reflecting radiant heat are disposed.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: May 9, 2017
    Assignees: Waseda University, MicrotracBEL Corp.
    Inventors: Masahiko Matsukata, Kazuyuki Nakai, Masayuki Yoshida
  • Patent number: 9535004
    Abstract: In the present invention, excitation light is irradiated onto an analysis chip that has been placed in a chip holder, reflected light or transmitted light from the analysis chip is detected, and as a result the position information of the analysis chip is obtained. On the basis of this position information, the chip holder is moved by a conveyance stage and thereby moved to a measurement position. Excitation light is irradiated onto the analysis chip that is disposed at the measurement position, and fluorescence emitted from a fluorescent substance that marks the substance to be detected is detected.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: January 3, 2017
    Assignee: Konica Minolta, Inc.
    Inventors: Tetsuya Noda, Masataka Matsuo, Yoshimasa Hamano, Hiroshi Hirayama
  • Patent number: 9448219
    Abstract: One aspect of the invention relates to an ultrathin micro-electromechanical chemical sensing device which uses swelling or straining of a reactive organic material for sensing. In certain embodiments, the device comprises a contact on-off switch chemical sensor. For example, the device can comprises a small gap separating two electrodes, wherein the gap can be closed as a result of the swelling or stressing of an organic polymer coating on one or both sides of the gap. In certain embodiments, the swelling or stressing is due to the organic polymer reacting with a target analyte.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: September 20, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: William Jay Arora, Karen K. Gleason, George Barbastathis, Wyatt E. Tenhaeff
  • Patent number: 9415394
    Abstract: A microfluidic chip (100) with a flow-guiding body (111) and the applications thereof in biochemistry, immunology, and molecule detection. The flow-guiding body (111) is disposed in a solution tank (101) of the microfluidic chip (100), the surface of the flow-guiding body (111) is enclosed by the antigen or antibody, and the gap between the flow-guiding body (111) and a wall (105) of the solution tank is 0 mm to 1.5 mm.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: August 16, 2016
    Inventor: Qi Yang
  • Patent number: 9228974
    Abstract: The present disclosure provides a biological field effect transistor (BioFET) and a method of fabricating a BioFET device. The method includes forming a BioFET using one or more process steps compatible with or typical to a complementary metal-oxide-semiconductor (CMOS) process. The BioFET device includes a plurality of microwells having a bio-sensing layer and a number of stacked well portions over a multi-layer interconnect (MLI). A bottom surface area of a well portion is different from a top surface area of a well portion directly below. The microwells are formed by removing a top metal plate on a topmost level of the MLI.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: January 5, 2016
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Yi-Hsien Chang, Wei-Cheng Shen, Shih-Wei Lin, Chun-Ren Cheng
  • Patent number: 9073053
    Abstract: An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
    Type: Grant
    Filed: September 22, 2005
    Date of Patent: July 7, 2015
    Assignee: Cepheid
    Inventors: Michael T. Taylor, Phillip Belgrader, Farzad Pourahmadi, William A. McMillan, Ronald Chang, Stanley H. Sakai, Jesus Ching
  • Publication number: 20150147823
    Abstract: Methods, devices, reagent, systems and kits for the detection, diagnosis of ovarian cancer as well as for the monitoring of ovarian cancer progression and for monitoring the progress of ovarian cancer treatments using BNP as a biomarker.
    Type: Application
    Filed: October 28, 2014
    Publication date: May 28, 2015
    Applicant: Autotelic LLC
    Inventor: Vuong Trieu
  • Publication number: 20150147804
    Abstract: The present invention relates to a biochemical analysis cartridge having improved operability. More particularly, the present invention provides a biochemical analysis cartridge including an insertion-type sample cartridge and a reaction cartridge receiving the insertion-type sample cartridge, in which,as the sample cartridge is inserted into the reaction cartridge,a reaction solution chamber moves toward a broken part of a covertape so as to automatically supply the reaction solution stored in the chamber. The biochemical analysis cartridge having improved operability according to the present invention can induce the mixing between a sample and a reaction solution by simply inserting them into the reaction cartridge and a reaction thereafter, thereby minimizing the process of a measurer to intervene in the assay, and subsequently improving user convenience and operability.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 28, 2015
    Inventors: Geun Sig CHA, Hakhyun NAM, Dongxuan SHEN, Joo Young CHO, Jihoon KIM
  • Publication number: 20150147821
    Abstract: Systems and methods are provided for detecting or measuring binding affinity between different compositions. The methods include contacting one or more magnetic beads having a surface including a first composition with a substrate having a surface including a second composition; applying a rotating magnetic field to the one or more magnetic beads effective to cause the one or more magnetic beads to move across the surface of the substrate; measuring the movement of the one or more magnetic beads across the substrate surface to determine a translational velocity; and determining a binding affinity between the first and second compositions from the translational velocity.
    Type: Application
    Filed: May 15, 2013
    Publication date: May 28, 2015
    Applicant: Massachusetts Instiute of Technology
    Inventors: Charles E. Sing, Joshua P. Steimel, Alfredo Alexander-Katz
  • Publication number: 20150148661
    Abstract: A system for measuring analyte concentrations has porous-walled nanocontainers containing multiple magnetic nanoparticles, the magnetic nanoparticles coated with a selective binder that is analyte-responsive and binds a the analyte, an indicator substance releasable from the selective binder by the analyte, or an indicator substance cleavable by the analyte, apparatus for exposing the nanocontainers to a fluid potentially containing the analyte, and magnetic spectroscopy of Brownian motion sensing apparatus for detecting agglutination of the nanoparticles or binding of analyte to the nanoparticles.
    Type: Application
    Filed: June 14, 2013
    Publication date: May 28, 2015
    Applicant: The Trustees of Dartmouth College
    Inventors: John B. Weaver, Barjor Gimi, Karl Griswold
  • Publication number: 20150147818
    Abstract: The present invention relates to a sensor capable of detecting an aromatic nitro compound explosive, and a preparation method thereof, and more specifically, to a nanosensor system, and a detection method using the same, wherein a quantum dot-based sensor for detecting an aromatic nitro compound explosive can conveniently detect an aromatic nitro compound explosive with high sensitivity on the basis of a change in energy transfer between quantum dots. The method for detecting an explosive of the present invention makes an explosive come in contact with a quantum dot thin film to which an explosive can combine, and measures a change in fluorescence wavelength, thereby sensing an explosive.
    Type: Application
    Filed: May 6, 2013
    Publication date: May 28, 2015
    Inventors: Sungjee Kim, Nayoun Won, Jungheon Kwag, Joonhyuck Park, Ho Jin
  • Publication number: 20150148238
    Abstract: The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet microactuator including a droplet including one or more beads and immobilizing at least one of the one or more beads. The method further includes conducting one or more droplet operations to divide the droplet to yield a set of droplets including a droplet including the one or more immobilized beads and a droplet substantially lacking the one or more immobilized beads.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 28, 2015
    Applicants: ADVANCED LIQUID LOGIC, INC., Duke University
    Inventors: Vamsee Pamula, Vijay Srinivasan, Michael G. Pollack, Richard B. Fair
  • Publication number: 20150140582
    Abstract: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g. an enzyme, fluorescent or direct label etc.) wherein said conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e. which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
    Type: Application
    Filed: December 29, 2014
    Publication date: May 21, 2015
    Inventor: Juergen Klepp
  • Publication number: 20150139857
    Abstract: A biochip includes a substrate, where the substrate includes at least one hole extending from a first surface of the substrate to a second surface of the substrate opposite the first surface, and where the substrate comprises a microfluidic channel pattern. The biochip further includes a surface modification layer over the substrate. Additionally, the biochip includes a sensing wafer bonded to the substrate, where the sensing wafer has one or more modified surface patterns having different surface properties from each other.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 21, 2015
    Inventors: Yi-Shao LIU, Chun-Wen CHENG, Chun-Ren CHENG
  • Publication number: 20150140556
    Abstract: The present invention provides, in addition to other things, methods, systems, and apparatuses that involve the use of an optical fiber with grating and particulate coating that enables simultaneous heating; optical detection; and optionally temperature measurement. Methods, systems, and apparatuses of the present invention may be used in many applications including isothermal and/or thermal cycling reactions. In certain embodiments, the present invention provides methods, systems, and apparatuses for use in detecting, quantifying and/or identifying one or more known or unknown analytes in a sample.
    Type: Application
    Filed: June 20, 2013
    Publication date: May 21, 2015
    Inventors: Jacques Albert, Anatoli Ianoul, Aliaksandr Bialiayeu, Adam Bottomley
  • Publication number: 20150140552
    Abstract: The present invention related to a quantitative assay device and a method for the determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid connection with the test membrane and a porous downstream membrane in fluid connection with the test membrane, wherein the test membrane contains two bands having deposited on there high and low concentrations of different calibrator agents and a test band capable of reacting with conjugated analyte complexes giving rise to a measurable signal.
    Type: Application
    Filed: November 13, 2014
    Publication date: May 21, 2015
    Inventor: Jin Po LEE