With Coagulometer For Agglutination, Clotting, Or Prothrombin, Or For Particle (e.g., Cell, Etc.) Counting, Or Volume Or Characteristics Determination Patents (Class 422/73)
  • Patent number: 10379128
    Abstract: Systems, apparatuses and methods include evaluation the clotting time or strength of clotting in the presence of various clot-affecting reagents to obtain a profile of clot analysis for determination of bleeding complications. The various reagents may be included in a single cartridge for use in a blood clotting analysis device.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: August 13, 2019
    Assignee: MEDTRONIC, INC.
    Inventors: Charlene Yuan, Trevor Huang
  • Patent number: 10302548
    Abstract: A fluorescent particle measuring method comprising the steps of trapping a fluorescent particle included in a fluid that is to be evaluated; identifying, by a material analyzing device, a material of a fluorescent particle that has been trapped; measuring, by a fluorescent particle measuring device, a number of fluorescent particles included in the fluid; and identifying, as the material of a fluorescent particle that has been measured by the fluorescent particle measuring device, a material identified by the material analyzing device.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: May 28, 2019
    Assignee: Azbil Corporation
    Inventor: Norio Hasegawa
  • Patent number: 10139334
    Abstract: A particulate measurement device includes: a nozzle which discharges liquid from an opening to form a flow of the liquid; a light emitter which emits light such that the light propagates in a region where the flow of the liquid is formed; a photodetector provided outside the region to receive the light from a partial region extending along a longitudinal direction of the region; and an air flow forming unit which forms a flow of gas along a direction in which the liquid flows, on an outer periphery of the region.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: November 27, 2018
    Assignee: TOKYO ELECTRON LIMITED
    Inventors: Akitake Tamura, Kaoru Fujihara
  • Patent number: 10100278
    Abstract: A multi-channel system for classifying particles in a mixture of particles according to one or more characteristics including a common source of electromagnetic radiation for producing a beam of electromagnetic radiation and a beam splitter for producing multiple beams of electromagnetic radiation for directing multiple beams of electromagnetic radiation to each interrogation location associated with each flow channel of the multi-channel system.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: October 16, 2018
    Assignee: Inguran, LLC
    Inventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
  • Patent number: 10087440
    Abstract: An integrated “lab-on-a-chip” microfluidic device performs nucleic acid sample preparation and diagnostic analysis from test samples containing cells and/or particles. The device analyzes DNA or RNA targets, or both, from a common test sample. Dried and/or liquid reagents necessary for nucleic acid sample preparation and analysis are contained on the device, such that the device only requires addition of test sample. Clay mineral and alkaline buffer reagents are employed for overcoming the problems of nucleic acid degradation and contamination during sample preparation. The device may include a composite filter to separate plasma or serum from other blood constituents when the test sample is a blood product. The microfluidic device utilizes a plurality of microfluidic channels, inlets, valves, membranes, pumps, and other elements arranged in various configurations to manipulate the flow of the liquid sample, in particular, in order to prepare nucleic acids and perform further diagnostic analysis.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: October 2, 2018
    Assignee: Micronics, Inc.
    Inventors: Alan K. Lofquist, C. Frederick Battrell, Heather K. Bouzek
  • Patent number: 10036697
    Abstract: Disclosed is a sheath delivery system that uses a continuous flow of sheath fluid into a pressurized internal reservoir that substantially matches the outflow of sheath fluid through the nozzle of a flow cytometer. A substantially constant level of the sheath fluid is maintained. If the sheath fluid level falls below a desired level, or goes above a desired level, a dampened control system is used to reach the desired level. In addition, air pressure in the pressurized internal container is controlled so that an external sheath container can be removed and refilled with additional sheath fluid without stopping the sheath delivery system 100. Differences in pressure are detected by a droplet camera, which measures the droplet breakoff point to determine the pressure of the sheath fluid in the nozzle.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: July 31, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Daniel Nelson Fox, Nathan Michael Gaskill-Fox
  • Patent number: 9987631
    Abstract: A particle processing device includes a chamber and at least one capturing structure. The chamber is connected to a first port and a second port to provide a space between the first and second ports for flowing of a fluid having a particle. The capturing structure is provided in the chamber to form a fluidic channel, wherein the fluidic channel has a first opening and a second opening and a capturing region is formed between the first and second openings such that the capturing region has a changeable sectional shape for capturing the particle in the fluid flowing from the first port to the second port.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: June 5, 2018
    Assignee: NEXVIVO CO., LTD.
    Inventors: Young-Ho Cho, Il Doh, Hwan-Il Yoo
  • Patent number: 9983220
    Abstract: The present invention relates to an apparatus and a method for testing a function and a drug response of a platelet based on a microfluidic chip. The apparatus for test comprises a measuring device containing a blood sample and measuring aggregation and adhesion of a platelet generated by flow of the blood sample; and a fluid driving device which is connected to the measuring device and generates a oscillating shear flow of the blood sample. Therefore, activation of factors such as a platelet and von Willebrand factor (vWF) etc. can be activated uniformly and completely, and a repeatability of the platelet aggregation can be increased.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: May 29, 2018
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Se Hyun Shin, Chae Seung Lim
  • Patent number: 9975118
    Abstract: A cell study device, comprising, a base layer, a planar conduit defining layer, including a conduit cut out of the layer; and a planar cover layer which defines a capillary flow channel in said conduit layer, said conduit layer and said cover layer acting as side walls for said capillary flow channel, wherein said layers are formed of materials that do not interfere with cell behavior over a period of at least 5 hours when loaded with aqueous solution.
    Type: Grant
    Filed: December 25, 2008
    Date of Patent: May 22, 2018
    Assignee: Seng Enterprises Ltd.
    Inventors: Mordechai Deutsch, Assaf Deutsch
  • Patent number: 9977039
    Abstract: Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: May 22, 2018
    Assignee: HemoSonics LLC
    Inventors: Francesco Viola, William F. Walker, Gregory V. Browne, Robert S. Magyar, Bjarne Hansen, Christopher G. Denny
  • Patent number: 9952076
    Abstract: Apparatus and methods are described for automatically performing set-up steps for flow cytometry operations. The invention provides for the spatial determination of a flow stream and the subsequent automatic alignment of analysis devices and/or collection vessels. The automatic determination of flow stream properties provides for the automatic configuration flow cytometer parameters.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: April 24, 2018
    Assignee: Becton, Dickinson and Company
    Inventors: Pierce O. Norton, Vladimir Azersky
  • Patent number: 9849456
    Abstract: Disclosed herein is a microfluidic device comprising, at least one sample inlet for receiving biological cells in a biological fluid sample; at least one sheath flow inlet for receiving a sheath fluid; at least one curvilinear channel configured to provide the biological fluid sample substantially in an outer flow and the sheath fluid in substantially an inner separated flow; a plurality of cell traps at the periphery of the curvilinear channel, each trap configured to admit a single cell having a targeted size range from the outer flow.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: December 26, 2017
    Assignee: Clearbridge Mfluidics Pte. Ltd.
    Inventor: Swee Jin Tan
  • Patent number: 9816983
    Abstract: A sample analyzer comprising: a sample preparing section for preparing first and second measurement sample including reagent and sample; a first detector for detecting a predetermined component in the first measurement sample prepared by the sample preparing section; a second detector for detecting the predetermined component in the second measurement sample prepared by the sample preparing section; and a controller configured for performing operations, comprising: (a) controlling the first detector to detect the predetermined component in the first measurement sample prepared by the sample preparing section; (b) determining the reliability of the result detected by the first detector; (c) controlling the sample preparing section to prepare the second measurement sample from the same sample when the result has been determined to be unreliable; and (d) controlling the second detector to detect the predetermined component in the second measurement sample, is disclosed.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: November 14, 2017
    Assignee: SYSMEX CORPORATION
    Inventors: Daigo Fukuma, Takaaki Nagai, Masaharu Shibata
  • Patent number: 9753024
    Abstract: An apparatus for determining blood clotting capacity comprises an actuator to cyclically move a member within a sample of blood received in a well in a tray and one of a deflection sensor and a position sensor to determine the position of the wetted member upon being acted upon by the actuator. The theoretical position of the wetted member, as determined using a known actuator force and wetted member physical data, is compared to the sensed deflection or position of the wetted member, and the resistance to movement of the wetted member caused by the blood is determined and correlated to a clotting capacity.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: September 5, 2017
    Assignee: Board of Regents of the University of Texas Systems
    Inventors: Brijesh S. Gill, Kevin Aroom, Charles Cox, Jr.
  • Patent number: 9638698
    Abstract: An analyte measurement system is provided having sensors with embossed test chamber channels. In one embodiment, the sensors are elongate test strips for in vitro testing, each test strip having a substrate, at least one electrode, an embossed channel in the electrode, and lidding tape covering at least a portion of the embossed channel. Methods of manufacture are also disclosed for filling the sensor channels with reagent, and for trimming the ends of the sensors to eliminate the need for a calibration code during use of the sensors with a meter.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: May 2, 2017
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Adrian Petyt, Simon A. Hector
  • Patent number: 9599601
    Abstract: A sample testing cartridge is usable to perform a variety of tests on a visco-elastic sample, such hemostasis testing on a whole blood or blood component sample. The cartridge includes a sample processing portion that is in fluid communication with a sample retention structure. A suspension, such as a beam, arm, cantilever or similar structure supports or suspends the sample retention portion relative to the sample processing portion in a unitary structure. In this manner, the sample retention portion may be placed into dynamic excitation responsive to excitation of the cartridge and correspondingly dynamic, resonant excitation of the sample contained within the sample retention portion, while the sample processing portion remains fixed. Observation of the excited sample yields data indicative of hemostasis. The data may correspond to hemostasis parameters such as time to initial clot formation, rate of clot formation, maximum clot strength and degree of clot lysis.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: March 21, 2017
    Assignee: CORAMED TECHNOLOGIES LLC
    Inventors: Peter Delmenico, Carlos G. Lopez-Espina, Gabriel Raviv
  • Patent number: 9588102
    Abstract: Embodiments of the present invention encompass automated systems and methods for analyzing white blood cell parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of white blood cell conditions in the individual.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: March 7, 2017
    Assignee: Beckman Coulter, Inc.
    Inventors: Patricio Vidal, Christophe Godefroy, Phaisit Chewputtanagul, Jiuliu Lu
  • Patent number: 9535065
    Abstract: The present disclosure provides cytometric methods for the detection of rare target cells in a sample. In certain aspects, the methods and compositions may facilitate the detection of rare target cells, such as circulating tumor cells (CTCs), in a biological sample such as blood. Aspects of the methods include contacting the sample with first and second binding members that specifically bind to a marker of the rare target cell, and cytometrically assaying the sample for the presence of cells comprising bound first and second binding members to detect the rare target cell in the sample. Also provided are systems, compositions, and kits for practicing the subject methods.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: January 3, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: Hrair Kirakossian, Edward Goldberg, Diether Recktenwald
  • Patent number: 9517474
    Abstract: Embodiments of the present disclosure provide for devices, methods for separating particles, and the like. In general, embodiments of the present disclosure include non-uniform magnetic field-assisted processes and devices for the separation of particles (e.g., cells) within a magnetic fluid. Under non-uniform magnetic fields, particles such as cells can experience the generated magnetic field direction to produce a magnetic buoyancy force, analogous to buoyancy force, as magnitude of the force is proportional to the volume of cell. This force can be used to spatially separate cells of different sizes. In some embodiments, devices for separating particles are provided having a magnetic device configured to direct a non-uniform magnetic force onto the magnetic fluid and the particles; and a plurality of outlets, wherein the non-uniform magnetic force causes the types of particles to be separated and flow into different outlets.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: December 13, 2016
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Leidong Mao, Taotao Zhu, Mark A. Eiteman
  • Patent number: 9494525
    Abstract: Provided is technology for blood clotting reactions capable of analyzing a blood clotting reaction with a high degree of precision, by precisely detecting and removing noise, regardless of the location where the noise is generated in the light intensity data. This automated analyzer approximates, with an approximation curve, time series data for transmitted light intensity or scattered light intensity of light emitted onto a sample, and, in this process, removes abnormal data points that deviate from the approximation curve (see FIG. 2).
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: November 15, 2016
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Shinji Tarumi, Chie Yabutani, Akihisa Makino, Chihiro Manri, Satoshi Mitsuyama
  • Patent number: 9494604
    Abstract: A method of characterizing the coagulation or sedimentation dynamics of a fluid such as whole blood, a blood fraction, or blood plasma is provided. The method includes illuminating a sample of the fluid with a beam of coherent light; acquiring a time series of images of a speckle pattern generated by interaction between the sample and the spatially coherent light beam; and processing the time series of images. The processing step includes calculating a function representative of the variation in the speckle pattern between two or more images of the series. The invention also provides a device for implementing such a method.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: November 15, 2016
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Patrick Pouteau, Magalie Faivre, Philippe Peltie, Anne Planat-Chretien
  • Patent number: 9447467
    Abstract: The present invention relates to a method of enriching fetal nuclei from a sample. Enriched fetal nuclei can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: September 20, 2016
    Assignee: GENETIC TECHNOLOGIES LIMITED
    Inventors: Richard Allman, Debbie Mantzaris, Eduardo Vom, Craig Matthew Lewis
  • Patent number: 9435725
    Abstract: A device for measuring permeability of a material sample, the device comprising: an input tank (1) configured to store fluid and to supply the fluid to a sample tank (2) positioned below the input tank (1) and configured to hold the material sample, such as to allow the fluid from the input tank (1) to permeate through the material sample; a receptacle (25) positioned under the sample tank (2) to collect drops of fluid permeated through the material sample; and a device (3) for measuring the mass of the drops collected in the receptacle (25) and coupled with a controlling and monitoring device (11) configured to store data on measured mass and measurement times.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: September 6, 2016
    Assignee: AKADEMIA GORNICZO-HUTNICZA IM. STANISLAWA STASZICA W KRAKOWIE
    Inventors: Adam Pilat, Anetta Undas, Michal Zabczyk
  • Patent number: 9423393
    Abstract: An analytical test cartridge is provided. The analytical test cartridge can be used for medical analyses of liquid samples removed from a patient, for example blood. The analytical test cartridge is configured to provide for titration experiments. An example of a titration experiment that can be performed with the arrangement, is titration of heparin with protamine. Methods of assembly and use are provided.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: August 23, 2016
    Assignee: International Technidyne Corporation
    Inventor: Kee Van Sin
  • Patent number: 9387476
    Abstract: A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: July 12, 2016
    Assignee: Illumina, Inc.
    Inventors: Helmy A. Eltoukhy, Tarun Khurana, Behnam Javanmardi, Poorya Sabounchi, Majid Aghababazadeh
  • Patent number: 9389175
    Abstract: Device and process to approximate somatic cell count (SCC) of untreated mammalian milk by the two variable equation SCC=f (FSL, FAT) with a forward scattered light factor (FSL) being obtained by detecting light scattered by the milk into an angular range within, and less than, the angular range 0.0 to 0.5 degrees away from the central axis of incident light, with a proxy (FAT) for the fat content of the milk, which may be obtained by detecting light attenuation of the milk sample, and with the function (f) being obtained by calibration of the device using reference milk samples.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: July 12, 2016
    Assignee: DESHPANDE, Satish
    Inventor: Satish Deshpande
  • Patent number: 9383298
    Abstract: A well plate (1) for holding samples of a bodily fluid during analysis thereof, typically in an analytical apparatus, includes a plate (2) having a plurality of first wells (3) extending downwardly therefrom for holding a sample during optical analysis of the sample, and a plurality of second wells (4) for holding samples during mechanical analysis of the samples. A plurality of holding wells (8) are provided for initially receiving and holding samples of the bodily fluid to be analysed so that samples of relatively accurate size can be pipetted from the holding wells (8) to the first and second wells (3,4).
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 5, 2016
    Assignee: Tcoag Ireland Limited
    Inventors: Ronan Patrick O'Caoimh, James Walsh, Brendan Kevin Farrell, Rory Peter Nealon, Josef Georg Hubert Wiehe
  • Patent number: 9372185
    Abstract: A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located on one side of the axis of motion. The movable structure is actuated by a separate force-generating apparatus, which is entirely separate from the movable structure formed on its substrate. This allows the movable structure to be entirely submerged in the sample fluid.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: June 21, 2016
    Assignees: Owl Biomedical, Inc., Innovative Micro Technology
    Inventors: John S Foster, Daryl W. Grummitt, Jaquelin K. Spong, Kimberley L. Turner, John C. Harley
  • Patent number: 9359677
    Abstract: A method for inhibiting corrosion comprises the steps of providing a fluid; adding a corrosion inhibitor comprising at least one amphiphilic chemical to the fluid; and monitoring micelles presence in the fluid. A method for determining the amount of corrosion inhibitor that is sufficient to inhibit corrosion, a method for monitoring the activity of an amphiphilic chemical and a system for inhibiting corrosion in a conduit are also disclosed.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: June 7, 2016
    Assignee: Lux Assure Limited
    Inventors: Cameron Mackenzie, Vjera Magdalenic, Artin Moussavi, Michael Joosten, Mohsen Achour, David J. Blumer
  • Patent number: 9354243
    Abstract: In some embodiments, the invention provides methods for detecting fibrinolysis or hyperfibrinolysis in a blood sample from a patient. The method includes subjecting a first portion of a blood sample comprising reduced platelet function to viscoelastic analysis in the absence of an inhibitor of fibrinolysis to obtain a coagulation characteristic of the first portion at a time point; and subjecting a second portion of the blood sample comprising reduced platelet function to viscoelastic analysis in the presence of an inhibitor of fibrinolysis to obtain a coagulation characteristic of the second portion at the time point; wherein a difference between the coagulation characteristic of the first portion and the coagulation characteristic of the second portion indicates fibrinolysis or hyperfibrinolysis in the blood sample.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: May 31, 2016
    Assignees: Haemonetics Corporation, The Regents of the University of Colorado, a body corporate
    Inventors: Michael P. Chapman, Ernest E. Moore, Katherine M. Norem
  • Patent number: 9297816
    Abstract: In one embodiment, a device for measuring blood coagulation includes a substrate having a surface, an optical waveguide provided on the surface of the substrate, the waveguide having a tip, and means for spatially separating objects from the tip of the waveguide.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: March 29, 2016
    Assignee: University of South Florida
    Inventor: Anna Pyayt
  • Patent number: 9285311
    Abstract: An optical system for performing scattering and absorbance assays in clinical diagnostics comprises a light source for emitting collimated light parallel to an optical axis in an optical path, a sample holding unit comprising at least one sample holding position located in the optical path and an optical detector for measuring light transmitted through a sample located in a sample holding position. The optical system further comprises an adjustable light angle selector adjusted to prevent light transmitted through the sample and diverging from the optical axis with an angle greater than a certain value from reaching the detector when a scattering assay is performed, and wherein the light angle selector is adjusted to allow light transmitted through the sample and diverging from the optical axis with an angle smaller than a certain value to reach the detector when an absorbance assay is performed.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: March 15, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Rik Harbers
  • Patent number: 9272280
    Abstract: Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: March 1, 2016
    Assignee: HemoSonics LLC
    Inventors: Francesco Viola, William F. Walker, Gregory V. Browne, Robert S. Magyar, Bjarne Hansen, Christopher G. Denny, Karen Platt
  • Patent number: 9243993
    Abstract: A sample analyzer capable of operating in a first measuring mode for measuring a sample and a second measuring mode for measuring a sample, comprising: a sample provider for providing a sample; a common reagent provider for providing a common reagent used in the first measuring mode and the second measuring mode; a special reagent provider for providing a special reagent used in the second measuring mode; a mode selector for selecting one of the first measuring mode and the second measuring mode; a measuring section for measuring the sample; and wherein in the first measuring mode, the sample provider and the common reagent provider operate so as to make a first mode sample comprising the sample and the common reagent, and the measuring section operates so as to measure the first mode sample, and in the second measuring mode, the sample provider, the common reagent provider and the special reagent provider operate so as to make a second mode sample comprising the sample, the common reagent and the special rea
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: January 26, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Takaaki Nagai, Masaharu Shibata, Noriyoshi Yoshida, Shoichiro Asada
  • Patent number: 9174216
    Abstract: A system and method for capturing and analyzing cells comprising: a fluid delivery module; a reservoir configured to receive a biological sample including a target cell population and at least one fluid from the fluid delivery module; a manifold configured to receive and distribute the biological sample and at least one fluid from the reservoir into a cell capture device; a waste chamber configured to couple to the manifold; and a pump configured to couple to the waste chamber. In embodiments of the system configured to promote further purification of captured cells, the system can further comprise a magnet that enables further separation of captured cells from undesired sample materials. The system can additionally further comprise a heater configured to heat at least one fluid and/or biological sample, and a cell capture device configured to couple to the manifold, in order to facilitate capture of the target cell population.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 3, 2015
    Assignee: DeNovo Science, Inc.
    Inventors: Kalyan Handique, Kyle Gleason, Austin Payne, Priyadarshini Gogoi, Saedeh Sepehri Javdani, Christopher Siemer, Yi Zhou
  • Patent number: 9165359
    Abstract: The invention provides a method and apparatus for isolating individual target cells. The apparatus includes a body structure comprising a main channel, a collection channel, and a waste channel fluidly coupled at a first fluid junction. A plurality of trapping channels intersect the collection channel, each trapping channel having a diameter at a location adjacent to the intersection of the trapping channel with the collection channel that is less than a diameter of an individual target cell. The apparatus also includes an imaging system configured to image individual target and non-target cells within the main channel, thereby producing imaging data; a processor configured to perform real-time, multivariate analyses of the imaging data; and a directing system configured to direct the individual target cells. A pressure source is in fluid communication with one or more of the collection channel, the waste channel, the first side channel, and the second side channel.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: October 20, 2015
    Assignee: Caliper Life Sciences
    Inventors: Rajiv Bharadwaj, Bahram Fathollahi
  • Patent number: 9087371
    Abstract: There is provided a microparticle sorting device that automatically optimizes a fluid stream. There is provided a microparticle sorting device that includes a voltage supply unit that supplies a driving voltage to a vibratory element that applies vibration to an orifice that produces a fluid stream, a charge unit that imparts charge to at least some droplets ejected from the orifice, deflecting plates, arranged opposing each other with the fluid stream S therebetween, that vary a travel direction of the droplets, and a first image sensor that acquires an image of the droplets passing between the deflecting plates.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: July 21, 2015
    Assignee: Sony Corporation
    Inventor: Yosuke Muraki
  • Patent number: 9068966
    Abstract: A sample testing cartridge is usable to perform a variety of tests on a viscoelastic sample, such hemostasis testing on a whole blood or blood component sample. The cartridge includes a sample processing portion that is in fluid communication with a sample retention structure. A suspension, such as a beam, arm, cantilever or similar structure supports or suspends the sample retention portion relative to the sample processing portion in a unitary structure. In this manner, the sample retention portion may be placed into dynamic excitation responsive to excitation of the cartridge and correspondingly dynamic, resonant excitation of the sample contained within the sample retention portion, while the sample processing portion remains fixed. Observation of the excited sample yields data indicative of hemostasis. The data may correspond to hemostasis parameters such as time to initial clot formation, rate of clot formation, maximum clot strength and degree of clot lysis.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 30, 2015
    Assignee: Coramed Technologies, LLC
    Inventors: Peter Delmenico, Carlos G. Lopez-Espina, Gabriel Raviv
  • Publication number: 20150147777
    Abstract: An integrated fluidic device comprising includes an input chamber that provides an input of a sample fluid, and a first overspill chamber in fluid communication with the input chamber. A metering conduit is in fluid communication with the fluid input chamber and the first overspill chamber. The metering conduit meters a first metered volume of fluid from the sample fluid, and the first overspill chamber receives fluid in excess of the first metered volume of fluid. A second overspill chamber is in fluid communication with the metering conduit. The metering conduit meters a second metered volume of fluid from the first metered volume of fluid, and the second overspill chamber receives fluid from the first metered volume of fluid in excess of the second metered volume of fluid. The second overspill chamber has a fluid actuated closable valve for controlling the metering of the second metered volume of fluid.
    Type: Application
    Filed: November 22, 2013
    Publication date: May 28, 2015
    Applicant: SHARP KABUSHIKI KAISHA
    Inventor: Pamela Ann Dothie
  • Patent number: 9040304
    Abstract: A multi-channel system and methods for sorting particles according to one or more characteristics of the particles. The system includes multiple flow cytometry units, each unit can have a nozzle for producing a fluid stream containing a desired population of particles in a mixture of particles. Each of the units may be operable to sort said desired population of particles by interrogating the fluid stream with a beam of electromagnetic radiation and classifying particles based on one or more characteristics of the particles. The system also includes a common fluid delivery system for delivering sheath fluid to each flow cytometer unit for producing respective fluid streams.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: May 26, 2015
    Assignee: Inguran, LLC
    Inventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
  • Publication number: 20150140671
    Abstract: A microfluidic sensor (10), such as an electrochemical blood test strip, with more accurate measurement comprises a plurality of channels (24) through which a fluid to be tested flows via a capillary action. One or more electrodes (30) are located under the channels (24). As the fluid flows over the electrodes (30) in the channels (24), the impedance between the electrodes (30) may be measured to determine fluid properties. In order to increase the accuracy of the measurements, the electrode deposition may be configured to be less than 10 ?m in thickness via a printing process with high process consistency, thereby reducing the disruption of the electrode deposition on the fluid flow.
    Type: Application
    Filed: November 18, 2013
    Publication date: May 21, 2015
    Applicant: JOHNSON ELECTRIC S.A.
    Inventor: Libing Zhang
  • Patent number: 9034260
    Abstract: The invention provides a device and a method for flow cytometric fractionation of particles contained in a fluid stream, wherein sections of the fluid stream, especially droplets if the fluid stream is a droplet stream, are irradiated with a laser. The laser disposed for the irradiation of the sections of the fluid stream can have a wavelength which is absorbed by the fluid and can have a sufficient radiation duration and radiation intensity to deflect sections of the fluid stream.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: May 19, 2015
    Assignee: MASTERRIND, GmbH
    Inventors: Heiko Meyer, Raoul Amadeus Lorbeer, Alexander Heisterkamp, Detlef Rath
  • Patent number: 9034264
    Abstract: The present application provides apparatus and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator. Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: May 19, 2015
    Assignee: Highland Biosciences Limited
    Inventor: Richard Day
  • Patent number: 9034261
    Abstract: A system and method are disclosed in which particles sorted by a flow cytometer may be deposited directly into a deposition layer formed on the surface of an optical disc, and information regarding measurements made of the particle, as well as the storage location of the particle, can be written to the recording layer of the optical disc.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: May 19, 2015
    Assignees: Sony Corporation, Sony Corporation of America
    Inventors: Masanobu Yamamoto, Michael D. Zordan, Gary P. Durack, Larry W. Arnold
  • Patent number: 9034259
    Abstract: One embodiment of the present invention is to provide a system for sorting cell particles in a liquid flow, which comprises a flow-defining block including a flow chamber receiving a sample conduit and a flow cell having a flow channel. The system also comprises a strobe block including a imaging device for taking an image of a jet flow ejected from the flow-defining block and a plurality of droplets in a given image area. The flow-defining block and the strobe block are detachably connected each other. Further the strobe block includes a nozzle plate having a nozzle channel between a receiving end and a nozzle. The flow-defining block includes a discharge end opposite to the receiving end and a channel enlarged portion of which cross section taken along a predetermined plane perpendicular to a flow direction has an area increasing towards the discharge end. The discharge end and the receiving end have substantially the same open distance in the predetermined plane perpendicular to the flow direction.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: May 19, 2015
    Assignee: BAY BIOSCIENCE KABUSHIKI KAISHA
    Inventor: Masahiko Kanda
  • Patent number: 9031701
    Abstract: An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: May 12, 2015
    Assignee: HemoSonics LLC
    Inventors: Francesco Viola, William F. Walker
  • Patent number: 9028771
    Abstract: The invention provides a modified form of saturation assay, which is based on the measurement of a free or unbound labelled reagent fraction (such that there is an increase in signal in the presence of analyte) and employs trapping zones to concentrate said unbound or free labelled fraction to avoid loss of sensitivity. Preferably, the assay is a membrane assay.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: May 12, 2015
    Assignee: Platform Diagnostics Limited
    Inventors: Douglas Robert Evans, Gerald John Allen, Carolyn Jennifer Ruddell
  • Patent number: 9028772
    Abstract: A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: May 12, 2015
    Assignee: Google Inc.
    Inventors: Huanfen Yao, Jeffrey George Linhardt, Babak Parviz
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Publication number: 20150125900
    Abstract: A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.
    Type: Application
    Filed: January 13, 2015
    Publication date: May 7, 2015
    Applicant: SYSMEX CORPORATION
    Inventors: Takaaki NAGAI, Noriyuki NARISADA, Daigo FUKUMA