With Coagulometer For Agglutination, Clotting, Or Prothrombin, Or For Particle (e.g., Cell, Etc.) Counting, Or Volume Or Characteristics Determination Patents (Class 422/73)
  • Patent number: 11366062
    Abstract: Disclosed herein is an apparatus comprising: a probe carrier comprising: a first substrate comprising a first plurality of through holes in the first substrate, a transparent window attached to the first substrate and across an opening of each of the first plurality of through holes, wherein the transparent window closes the opening; and probes attached to one or more locations on the transparent window, wherein interaction between the probes and an analyte generates a signal; a second substrate comprising a second plurality of through holes in the second substrate, wherein the second plurality of through holes are configured as a plurality of collimators; a sensor comprising a plurality of pixels configured to detect the signal.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: June 21, 2022
    Assignee: SHENZHEN GENORIVISION TECHNOLOGY CO., LTD.
    Inventors: Peiyan Cao, Yurun Liu
  • Patent number: 11366094
    Abstract: A thrombelastography device, a heating apparatus, a blood coagulation analysis system, and a rotational angle measurement method are disclosed. The thrombelastography device consists of a plurality of thrombelastography device splits (2) that are horizontally arranged in parallel. The thrombelastography device split (2) comprises a worktable (4), a rack (5), a test bar (6), a tester (8), and a processor (9). The thrombelastography device overcomes the defect in the prior art that the measurement result of a thrombelastography device is inaccurate. The amount of reflected light is used as a reference for thrombelastographic evaluation, and thus the result is more accurate.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: June 21, 2022
    Assignee: Haemonetics Corporation
    Inventors: Jian Xiao, Aiqin Chen, Bangzhong Yu, Feng Jiang
  • Patent number: 11366099
    Abstract: Among others, the present invention provides apparatus for detecting a disease, comprising a system delivery biological subject and a probing and detecting device, wherein the probing and detecting device includes a first micro-device and a first substrate supporting the first micro-device, the first micro-device contacts a biologic material to be detected and is capable of measuring at the microscopic level an electric, magnetic, electromagnetic, thermal, optical, acoustical, biological, chemical, physical, or mechanical property of the biologic material.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: June 21, 2022
    Assignee: AnPac Bio-Medical Science Co., Ltd.
    Inventors: Chris C. Yu, He Yu, Xuedong Du
  • Patent number: 11351536
    Abstract: A biochemical analysis system capable of sample preparation and processing can include at least one inlet channel having a non-fouling, slippery surface to autonomously transport a fluid sample to a chamber by a geometry of the at least one inlet channel. The at least one inlet channel can include a first end, which is open and exposed, and a second end connected to the chamber for mixing and reaction of the fluid sample, and the at least one inlet channel can include a converging or diverging angle.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: June 7, 2022
    Assignee: The Penn State Research Foundation
    Inventors: Pak Kin Wong, Tak-Sing Wong, Jing Wang, Hui Li, Yi Lu, Ying Wan
  • Patent number: 11288794
    Abstract: The present application describes a new device and method of use thereof, which allows identifying certain antigens and antibodies present in the blood. The device of the present invention is a closed device consisting of two parts, wherein the upper part has a chamber surrounded by LEDs illuminating the analysis plate, which is supported by the rotating platform. In turn, the rotating platform is connected to a motor that will promote the rotation thereof for mixing reagents with blood. After a period of time, the camera will capture and send the resulting image to a computer program that will analyze the sample, using image processing techniques.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: March 29, 2022
    Assignee: UNIVERSIDADE DO MINHO
    Inventors: Ana Patricia Da Silva Ferraz, Vitor Hugo Mendes Da Costa Carvalho
  • Patent number: 11255784
    Abstract: A method for determining the concentration of a fluorescent and/or fluorescence-labeled analyte, and to a calibration method for preparing such determination, for use in the field of biological and environmental analysis in order to improve the accuracy of concentration determination, comprising the following steps: performing fluorescence measurements for calibration samples that have predetermined concentrations of a plurality of fluorescent and/or fluorescence-labeled reference analytes Rj that differ from each other by values m of a diffusion measure characterizing the diffusion of the reference analyte, in order to determine the values i of a concentration-dependent parameter I; establishing functions Fj(c)=i which describe the dependence of the parameter I on the concentration; determining the values of a slope parameter a for the respective reference analyte as a derivative of the respective function at c=0; determining the values mj of the diffusion measure for the reference analytes; establishing the
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: February 22, 2022
    Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.
    Inventors: Benjamin Greiner, Lorenz Sparrenberg, Kristian Berwanger
  • Patent number: 11229722
    Abstract: A triple-chambered container includes: a main container body with a first chamber which has an opening at its distal end; a main barrel formed and movable longitudinally within the first chamber, the main barrel defining therein a second chamber for receiving fluids, the main barrel further having an apertured stopper at its distal end; a second barrel formed within the main barrel, the second barrel defining a third chamber for receiving fluids, the second barrel being movable longitudinally within and with respect to the main barrel, the second barrel having a distal end which is engageable and disengageable with the apertured stopper; a shaft adapted to fit within the second barrel, the shaft being movable longitudinally within and with respect to the second barrel, the shaft having a distal end which is engageable and disengageable with an aperture in the second barrel; a device for controlling engaging and disengaging of the distal end of the shaft with the aperture of the second barrel.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: January 25, 2022
    Inventors: Omer Peled, A. Jason Mirabito
  • Patent number: 11199533
    Abstract: A blood clot retraction assay device and methods of measuring whole-blood clot retractive forces during coagulation are described. When placed in proximity to a micro-beam, a blood droplet attaches thereto, applying a force to the micro-beam during clot formation. Using Piezoresistive micro-beams or other Piezoresistive components disposed upon such micro-beams, the device measures retractive force of a blood droplet based upon changes in resistance. The sensitivity of such measurements allows use of small quantities of blood for measurement, between 15 microliters and 300 microliters. The device further permits continuous measurement of coagulation, allowing measurement of distinct reaction, contraction development, and fibrinolysis phases for each blood sample.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: December 14, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jianping Fu, Kevin R. Ward, Zida Li, Xiang Li
  • Patent number: 11137335
    Abstract: Provided is a method for evaluating fluid flow characteristics of a lens-free complementary metal-oxide semiconductor (CMOS) optical sensor package module with a flow channel. The method includes: measuring a propagation profile and a flow velocity in an initial state flow of a fluid in the flow channel; calculating a first statistical parameter relating to flow characteristics of the fluid from the measured propagation profile and flow velocity; and comparing the calculated first statistical parameter with a preset reference value and evaluating quality of the flow channel according to the comparison result.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: October 5, 2021
    Assignee: SOL INC.
    Inventors: Jong Muk Lee, Seong Won Kwon, Ki Ho Jang, Jung Joon Ahn, Tae Young Lee
  • Patent number: 11085938
    Abstract: Some embodiments of a blood coagulation testing system include an analyzer console device and a single-use components configured to releasably install into the console device. In some embodiments, the blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site. The systems can be configured with features such as individual actuation systems for each measurement module, and firmware for initial and ongoing calibration and error detection.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: August 10, 2021
    Assignee: C A Casyso GmbH
    Inventors: Kevin Bels, Christian Brantl, Johannes Wittmann
  • Patent number: 11079718
    Abstract: The present invention relates to a method of detecting a possible infection of malaria in a patient using a digital optical microscope.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: August 3, 2021
    Assignee: Siemens Healthcare GmbH
    Inventors: Oliver Hayden, Lukas Richter, Matthias Ugele, Gaby Marquardt, Manfred Stanzel
  • Patent number: 11035779
    Abstract: A particle container includes a measurement section in which a measurement region is formed and the measurement section measurably accommodates multiple particles in the measurement region. The measurement section is configured to change a width of the measurement region in the measuring direction of measuring the particles.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: June 15, 2021
    Assignee: Canon Kabushiki Kaisha
    Inventor: Hisafumi Ebisawa
  • Patent number: 11014086
    Abstract: The present disclosure relates to a sensor arrangement (1) for analyzing substances in a material, comprising a substrate (2), a first reception area (5) for receiving a first material, an electronic component sensor (3), a test area (4) that is in contact with the electronic component sensor (3), and a control device (10). The first reception area (5) and the test area (4) are arranged on the substrate (2). The control device (10) is configured for controlling the first reception area (5) and/or the test area (4) to move a portion of the first material from the first reception area (5) into the test area (4). Further, the present disclosure relates to a method for operating such a sensor arrangement (1).
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: May 25, 2021
    Assignee: Technische Uniersität München
    Inventors: Vijay Deep Bhatt, Saumya Joshi, Paolo Lugli
  • Patent number: 10977766
    Abstract: The disclosure relates to devices, systems and methods for image registration and annotation. The devices include computer software products for aligning whole slide digital images on a common grid and transferring annotations from one aligned image to another aligned image on the basis of matching tissue structure. The systems include computer-implemented systems such as work stations and networked computers for accomplishing the tissue-structure based image registration and cross-image annotation. The methods include processes for aligning digital images corresponding to adjacent tissue sections on a common grid based on tissue structure, and transferring annotations from one of the adjacent tissue images to another of the adjacent tissue images.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: April 13, 2021
    Assignee: VENTANA MEDICAL SYSTEMS, INC.
    Inventors: Srinivas Chukka, Anindya Sarkar, Quan Yuan
  • Patent number: 10898895
    Abstract: This disclosure relates to an assembly for loading a sample liquid. The assembly comprises an entry port comprising an inlet and a gas vent, and a reservoir. The reservoir comprises a distal wall, a fin, and a continuous fluidic pathway. The fin comprises first and second surfaces and extends from the inlet towards the distal wall. The continuous fluidic pathway comprises a converging channel that is in fluidic communication with the inlet and is defined by the second surface of the fin, and a diverging channel that is defined by the first surface of the fin and is in fluidic communication with the gas vent. At a distal end of the fin, a width of the converging channel at most equals a width of the diverging channel, and the width of the converging channel at most equals a distance between the distal end of the fin and the distal wall.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: January 26, 2021
    Assignee: Talis Biomedical Corporation
    Inventors: Thomas H. Cauley, III, David Alexander Rolfe, Marc Valer Serra
  • Patent number: 10859484
    Abstract: Provided herein is a method for determining the volume or hemoglobin content of an individual red blood cell in a sample containing a population of red blood cells. The method may be performed on a hematology analyzer. Also provided are a hematology analyzer for performing the method and a computer-readable medium containing programming for performing the method.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: December 8, 2020
    Assignee: Abbott Laboratories
    Inventors: Giacomo Vacca, Martin Krockenberger, Diana Garrett
  • Patent number: 10822636
    Abstract: The invention relates to the field of blood clotting diagnosis and relates to a kinetic method for determining the fibrinogen concentration in a human plasma sample according to the Clauss method.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: November 3, 2020
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Dirk Greis, Norbert Zander
  • Patent number: 10816559
    Abstract: Some embodiments of a blood coagulation testing system include an analyzer console device and a single-use cartridge component configured to releasably install into the console device. In some embodiments, the blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: October 27, 2020
    Assignee: CA CASYSO AG
    Inventors: Michael Gorin, Robert S. Hillman, Cory Lee McCluskey, Hubert Martin Schwaiger
  • Patent number: 10788502
    Abstract: The present invention addresses a problem in which, when examining blood properties in measurements of thrombus formation capacity and platelet function or the like, measurement data is changed as a result of sedimentation of blood in reservoirs during measurement. An erythrocyte membrane ion transport inhibitor, such as disodium 4,4?-dinitrostilbene-2,2?-disulfonate (DNDS) or 4,4?-diisothiocyanatostilbene-2,2?-disulfonic acid (DIDS), is used to inhibit erythrocyte sedimentation, and accurate measurement data is obtained.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: September 29, 2020
    Assignee: FUJIMORI KOGYO CO., LTD.
    Inventors: Kazuya Hosokawa, Tomoko Wada
  • Patent number: 10775369
    Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: September 15, 2020
    Assignee: OPKO Diagnostics, LLC
    Inventors: Vincent Linder, David Steinmiller, Samuel K. Sia
  • Patent number: 10746749
    Abstract: The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: August 18, 2020
    Assignee: Abbott Point of Care Inc.
    Inventors: Gordon Bruce Collier, Paul Willis Johns, Smitha R K Sutrala, Dan Wang, Katrina Petronilla Di Tullio
  • Patent number: 10676774
    Abstract: A method for determining the bacterial charge in a liquid or semi-liquid product, including: preparing a quantity of liquid or semi-liquid product to be analyzed; keeping that quantity of liquid or semi-liquid product at a preset measuring temperature (Tm) and deriving values (?) representing an angle of electrical impedance of the liquid or semi-liquid product at predetermined time instants; deriving an indication of the presence of a bacterial charge in the liquid or semi-liquid product as a function of the time trend of the values (?) representing the angle of the electrical impedance.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: June 9, 2020
    Assignee: ALI GROUP S.R.L.—CARPIGIANI
    Inventors: Andrea Cocchi, Roberto Lazzarini
  • Patent number: 10662408
    Abstract: This disclosure relates to methods for sorting sperm cells in a microfluidic chip. In particular, various steps are incorporated to align and orienting sperm in flow channels, as well as, to determining sperm orientation and measure relative DNA content for analysis and/or sorting.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 26, 2020
    Assignee: Inguran, LLC
    Inventors: Johnathan Charles Sharpe, Nemanya Sedoglavich, Blair Morad, Donald Francis Perrault, Jr.
  • Patent number: 10633645
    Abstract: The present disclosure relates to the generation of an activated platelet product in which one or more of the presence or absence of clots, the timing of clot formation (if present), and/or the mechanical strength of clots (if present) is controlled by the presence or concentration of calcium ions during the activation process. In certain embodiments, the calcium ion concentration is controlled in the presence of pulsed electric fields or a chemical activator (e.g., thrombin) as part of the activation process.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: April 28, 2020
    Assignee: General Electric Company
    Inventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Steve Lambert Klopman
  • Patent number: 10583439
    Abstract: A microfluidic chip having a micro channel for processing a sample is provided. The micro channel may focus the sample by using focusing fluid and a core stream forming geometry. The core stream forming geometry may include a lateral fluid focusing component and one or more vertical fluid focusing components. A microfluidic chip may include a plurality micro channels operating in parallel on a microfluidic chip.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 10, 2020
    Assignee: CYTONOME/ST, LLC
    Inventors: Erin Koksal, Johnathan Charles Sharpe, Kristopher Scott Buchanan, Blair D. Morad
  • Patent number: 10578605
    Abstract: An apparatus for measuring blood clotting time includes a blood clot detection instrument and a cuvette for use with the blood clot detection instrument. The cuvette includes a blood sample receptor-inlet; a channel arrangement including at least one test channel for performing a blood clotting time measurement, a sampling channel having at least one surface portion that is hydrophilic, communicating with the blood sample receptor-inlet and the at least one test channel, and a waste channel having at least one surface portion that is hydrophilic, communicating with the sampling channel; and a vent opening communicating with the sampling channel. The sampling channel, the vent opening and the waste channel, coact to automatically draw a requisite volume of a blood sample deposited at the blood receptor-inlet, into the sampling channel.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: March 3, 2020
    Assignee: Instrumentation Laboratory Company
    Inventors: Gregory M. Colella, Henry D. Huang, Anthony F. Kuklo, Jr., Dimitri Shishkin, Maria Figueroa, James A. Mawhirt
  • Patent number: 10544391
    Abstract: This disclosure relates to methods for sorting sperm cells in a microfluidic chip. In particular, various steps are incorporated to align and orienting sperm in flow channels, as well as, to determining sperm orientation and measure relative DNA content for analysis and/or sorting.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 28, 2020
    Assignee: Inguran, LLC
    Inventors: Johnathan Charles Sharpe, Nemanya Sedoglavich, Blair Morad, Donald Francis Perrault, Jr.
  • Patent number: 10545143
    Abstract: Silica particles having a thiol group on a surface thereof, and satisfying the following conditions (a) to (c): (a) a particle diameter is 20 to 1,000 nm; (b) a density of the thiol group on the surface of the silica particles is 0.002 to 0.2 piece/nm2; and (c) a ratio (B/A) in terms of an amount B (piece/particle) of the thiol group existing on the surface of the silica particles to an amount A of sulfur elements in the silica particles (the number of sulfur elements derived from thiol per silica particle) is 0.10 to 0.60.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: January 28, 2020
    Assignee: FURUKAWA ELECTRIC CO., LTD.
    Inventors: Masataka Nishida, Nobumitsu Yamanaka, Kazutomi Miyoshi, Michio Ohkubo
  • Patent number: 10513679
    Abstract: A cell detection device and a cell detection method is provided with which it is possible to efficiently acquire images of cells to be measured. Cell detection device comprises flow cell through which a measurement specimen that contains particles is caused to flow, particle detector for detecting the particles in the measurement specimen supplied to flow cell, particle sorter for sorting particles that satisfy a detection condition and other particles on the basis of the result of detection performed by particle detector, specimen supply part for supplying, to flow cell, an image-capture specimen that includes detection-condition-satisfying particles that have been sorted by particle sorter, and particle-image-capture part for capturing images of the particles in the sorted image-capture specimen supplied to flow cell.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: December 24, 2019
    Assignee: SYSMEX CORPORATION
    Inventors: Seiichiro Tabata, Masatoshi Yanagida
  • Patent number: 10503868
    Abstract: The disclosure relates to devices, systems and methods for image registration and annotation. The devices include computer software products for aligning whole slide digital images on a common grid and transferring annotations from one aligned image to another aligned image on the basis of matching tissue structure. The systems include computer-implemented systems such as work stations and networked computers for accomplishing the tissue-structure based image registration and cross-image annotation. The methods include processes for aligning digital images corresponding to adjacent tissue sections on a common grid based on tissue structure, and transferring annotations from one of the adjacent tissue images to another of the adjacent tissue images.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: December 10, 2019
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Srinivas Chukka, Anindya Sarkar, Quan Yuan
  • Patent number: 10481168
    Abstract: Provided are devices, systems and methods for evaluation of hemostasis. In some embodiments, an apparatus is disclosed comprising a housing; a plurality of test chambers located in the housing, the plurality of test chambers including chambers configured for measurements via a system that interrogates one or more viscoelastic properties of test samples in the test chambers, wherein the one or more viscoelastic properties is used to characterize dynamics of coagulation and/or fibrinolysis.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: November 19, 2019
    Assignee: HemoSonics LLC
    Inventors: Francesco Viola, William F. Walker, Gregory V. Browne, Robert S. Magyar, Bjarne Hansen, Christopher G. Denny
  • Patent number: 10458976
    Abstract: Early warning of changing health and robustness is given by tracking of ease of morphological changes in blood cells obtained by comparing intensities in a first scattered light intensity angular distribution and intensities in a second scattered light intensity angular distribution, with the light being scattered by blood cells into very narrowly forward scattered light intensity angular range.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: October 29, 2019
    Assignee: Satish DESHPANDE
    Inventor: Satish Deshpande
  • Patent number: 10449539
    Abstract: A fluid-containing cartridge for a tissue processing apparatus includes a body defining a plurality of discrete fluid passageways, and a plurality of fluid-containing wells that are disposed on the body, wherein each fluid passageway of the body defines a fluid path between one of the fluid-containing wells and a fluid exit port that is configured to dispense fluid onto a laboratory slide.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: October 22, 2019
    Assignee: RUSHABH INSTRUMENTS, INC.
    Inventors: Preyas Shah, Sahil Shah, Eli Endres, Joseph Lessard
  • Patent number: 10379128
    Abstract: Systems, apparatuses and methods include evaluation the clotting time or strength of clotting in the presence of various clot-affecting reagents to obtain a profile of clot analysis for determination of bleeding complications. The various reagents may be included in a single cartridge for use in a blood clotting analysis device.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: August 13, 2019
    Assignee: MEDTRONIC, INC.
    Inventors: Charlene Yuan, Trevor Huang
  • Patent number: 10302548
    Abstract: A fluorescent particle measuring method comprising the steps of trapping a fluorescent particle included in a fluid that is to be evaluated; identifying, by a material analyzing device, a material of a fluorescent particle that has been trapped; measuring, by a fluorescent particle measuring device, a number of fluorescent particles included in the fluid; and identifying, as the material of a fluorescent particle that has been measured by the fluorescent particle measuring device, a material identified by the material analyzing device.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: May 28, 2019
    Assignee: Azbil Corporation
    Inventor: Norio Hasegawa
  • Patent number: 10139334
    Abstract: A particulate measurement device includes: a nozzle which discharges liquid from an opening to form a flow of the liquid; a light emitter which emits light such that the light propagates in a region where the flow of the liquid is formed; a photodetector provided outside the region to receive the light from a partial region extending along a longitudinal direction of the region; and an air flow forming unit which forms a flow of gas along a direction in which the liquid flows, on an outer periphery of the region.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: November 27, 2018
    Assignee: TOKYO ELECTRON LIMITED
    Inventors: Akitake Tamura, Kaoru Fujihara
  • Patent number: 10100278
    Abstract: A multi-channel system for classifying particles in a mixture of particles according to one or more characteristics including a common source of electromagnetic radiation for producing a beam of electromagnetic radiation and a beam splitter for producing multiple beams of electromagnetic radiation for directing multiple beams of electromagnetic radiation to each interrogation location associated with each flow channel of the multi-channel system.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: October 16, 2018
    Assignee: Inguran, LLC
    Inventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
  • Patent number: 10087440
    Abstract: An integrated “lab-on-a-chip” microfluidic device performs nucleic acid sample preparation and diagnostic analysis from test samples containing cells and/or particles. The device analyzes DNA or RNA targets, or both, from a common test sample. Dried and/or liquid reagents necessary for nucleic acid sample preparation and analysis are contained on the device, such that the device only requires addition of test sample. Clay mineral and alkaline buffer reagents are employed for overcoming the problems of nucleic acid degradation and contamination during sample preparation. The device may include a composite filter to separate plasma or serum from other blood constituents when the test sample is a blood product. The microfluidic device utilizes a plurality of microfluidic channels, inlets, valves, membranes, pumps, and other elements arranged in various configurations to manipulate the flow of the liquid sample, in particular, in order to prepare nucleic acids and perform further diagnostic analysis.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: October 2, 2018
    Assignee: Micronics, Inc.
    Inventors: Alan K. Lofquist, C. Frederick Battrell, Heather K. Bouzek
  • Patent number: 10036697
    Abstract: Disclosed is a sheath delivery system that uses a continuous flow of sheath fluid into a pressurized internal reservoir that substantially matches the outflow of sheath fluid through the nozzle of a flow cytometer. A substantially constant level of the sheath fluid is maintained. If the sheath fluid level falls below a desired level, or goes above a desired level, a dampened control system is used to reach the desired level. In addition, air pressure in the pressurized internal container is controlled so that an external sheath container can be removed and refilled with additional sheath fluid without stopping the sheath delivery system 100. Differences in pressure are detected by a droplet camera, which measures the droplet breakoff point to determine the pressure of the sheath fluid in the nozzle.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: July 31, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Daniel Nelson Fox, Nathan Michael Gaskill-Fox
  • Patent number: 9987631
    Abstract: A particle processing device includes a chamber and at least one capturing structure. The chamber is connected to a first port and a second port to provide a space between the first and second ports for flowing of a fluid having a particle. The capturing structure is provided in the chamber to form a fluidic channel, wherein the fluidic channel has a first opening and a second opening and a capturing region is formed between the first and second openings such that the capturing region has a changeable sectional shape for capturing the particle in the fluid flowing from the first port to the second port.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: June 5, 2018
    Assignee: NEXVIVO CO., LTD.
    Inventors: Young-Ho Cho, Il Doh, Hwan-Il Yoo
  • Patent number: 9983220
    Abstract: The present invention relates to an apparatus and a method for testing a function and a drug response of a platelet based on a microfluidic chip. The apparatus for test comprises a measuring device containing a blood sample and measuring aggregation and adhesion of a platelet generated by flow of the blood sample; and a fluid driving device which is connected to the measuring device and generates a oscillating shear flow of the blood sample. Therefore, activation of factors such as a platelet and von Willebrand factor (vWF) etc. can be activated uniformly and completely, and a repeatability of the platelet aggregation can be increased.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: May 29, 2018
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Se Hyun Shin, Chae Seung Lim
  • Patent number: 9975118
    Abstract: A cell study device, comprising, a base layer, a planar conduit defining layer, including a conduit cut out of the layer; and a planar cover layer which defines a capillary flow channel in said conduit layer, said conduit layer and said cover layer acting as side walls for said capillary flow channel, wherein said layers are formed of materials that do not interfere with cell behavior over a period of at least 5 hours when loaded with aqueous solution.
    Type: Grant
    Filed: December 25, 2008
    Date of Patent: May 22, 2018
    Assignee: Seng Enterprises Ltd.
    Inventors: Mordechai Deutsch, Assaf Deutsch
  • Patent number: 9977039
    Abstract: Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: May 22, 2018
    Assignee: HemoSonics LLC
    Inventors: Francesco Viola, William F. Walker, Gregory V. Browne, Robert S. Magyar, Bjarne Hansen, Christopher G. Denny
  • Patent number: 9952076
    Abstract: Apparatus and methods are described for automatically performing set-up steps for flow cytometry operations. The invention provides for the spatial determination of a flow stream and the subsequent automatic alignment of analysis devices and/or collection vessels. The automatic determination of flow stream properties provides for the automatic configuration flow cytometer parameters.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: April 24, 2018
    Assignee: Becton, Dickinson and Company
    Inventors: Pierce O. Norton, Vladimir Azersky
  • Patent number: 9849456
    Abstract: Disclosed herein is a microfluidic device comprising, at least one sample inlet for receiving biological cells in a biological fluid sample; at least one sheath flow inlet for receiving a sheath fluid; at least one curvilinear channel configured to provide the biological fluid sample substantially in an outer flow and the sheath fluid in substantially an inner separated flow; a plurality of cell traps at the periphery of the curvilinear channel, each trap configured to admit a single cell having a targeted size range from the outer flow.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: December 26, 2017
    Assignee: Clearbridge Mfluidics Pte. Ltd.
    Inventor: Swee Jin Tan
  • Patent number: 9816983
    Abstract: A sample analyzer comprising: a sample preparing section for preparing first and second measurement sample including reagent and sample; a first detector for detecting a predetermined component in the first measurement sample prepared by the sample preparing section; a second detector for detecting the predetermined component in the second measurement sample prepared by the sample preparing section; and a controller configured for performing operations, comprising: (a) controlling the first detector to detect the predetermined component in the first measurement sample prepared by the sample preparing section; (b) determining the reliability of the result detected by the first detector; (c) controlling the sample preparing section to prepare the second measurement sample from the same sample when the result has been determined to be unreliable; and (d) controlling the second detector to detect the predetermined component in the second measurement sample, is disclosed.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: November 14, 2017
    Assignee: SYSMEX CORPORATION
    Inventors: Daigo Fukuma, Takaaki Nagai, Masaharu Shibata
  • Patent number: 9753024
    Abstract: An apparatus for determining blood clotting capacity comprises an actuator to cyclically move a member within a sample of blood received in a well in a tray and one of a deflection sensor and a position sensor to determine the position of the wetted member upon being acted upon by the actuator. The theoretical position of the wetted member, as determined using a known actuator force and wetted member physical data, is compared to the sensed deflection or position of the wetted member, and the resistance to movement of the wetted member caused by the blood is determined and correlated to a clotting capacity.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: September 5, 2017
    Assignee: Board of Regents of the University of Texas Systems
    Inventors: Brijesh S. Gill, Kevin Aroom, Charles Cox, Jr.
  • Patent number: 9638698
    Abstract: An analyte measurement system is provided having sensors with embossed test chamber channels. In one embodiment, the sensors are elongate test strips for in vitro testing, each test strip having a substrate, at least one electrode, an embossed channel in the electrode, and lidding tape covering at least a portion of the embossed channel. Methods of manufacture are also disclosed for filling the sensor channels with reagent, and for trimming the ends of the sensors to eliminate the need for a calibration code during use of the sensors with a meter.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: May 2, 2017
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Adrian Petyt, Simon A. Hector
  • Patent number: 9599601
    Abstract: A sample testing cartridge is usable to perform a variety of tests on a visco-elastic sample, such hemostasis testing on a whole blood or blood component sample. The cartridge includes a sample processing portion that is in fluid communication with a sample retention structure. A suspension, such as a beam, arm, cantilever or similar structure supports or suspends the sample retention portion relative to the sample processing portion in a unitary structure. In this manner, the sample retention portion may be placed into dynamic excitation responsive to excitation of the cartridge and correspondingly dynamic, resonant excitation of the sample contained within the sample retention portion, while the sample processing portion remains fixed. Observation of the excited sample yields data indicative of hemostasis. The data may correspond to hemostasis parameters such as time to initial clot formation, rate of clot formation, maximum clot strength and degree of clot lysis.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: March 21, 2017
    Assignee: CORAMED TECHNOLOGIES LLC
    Inventors: Peter Delmenico, Carlos G. Lopez-Espina, Gabriel Raviv
  • Patent number: 9588102
    Abstract: Embodiments of the present invention encompass automated systems and methods for analyzing white blood cell parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of white blood cell conditions in the individual.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: March 7, 2017
    Assignee: Beckman Coulter, Inc.
    Inventors: Patricio Vidal, Christophe Godefroy, Phaisit Chewputtanagul, Jiuliu Lu