Abstract: A method is described for evaporating liquid samples contained in sample holders mounted within a chamber and rotated by the rotor during an evaporation process in which the pressure in the chamber is reduced below atmospheric and the sample holders are rotated at high speed so as to exert centrifugal force on the contents of the holders. Heat is supplied to elevate the temperature of the liquid component of the samples to assist in the evaporation process. The temperature of the sample material is continuously or regularly monitored during the evaporation process and temperature signals are transmitted to a remote computing means which is programmed to generate a control signal for controlling the supply of heat to the samples and controlling the evaporation process. The temperature may be sensed by a probe in a sample holder containing an evaporating liquid sample, or in an adjoining sample holder containing a buffer liquid.

Abstract: The invention relates to a sample processing system for a plasma spectrometer for analysing viscous samples, and samples insoluble at room temperature. The system comprises a tray with tubes containing the sample, a heating block comprising a thermoregulation switch and means for collecting the sample from tubes. Said means are connected to a transfer tube transferring the solution that is pumped down by a peristaltic pump. The peristaltic pump is controlled by a controller box and comprises a first pump tubing of internal diameter &phgr; and a second pump tubing of internal diameter &phgr;′. A sample introduction system is fed by the peristaltic pump and contains a nebulizer and a spray chamber placed in a thermoregulated box. According to the invention, said sample processing system is thermoregulated, temperatures are variable and can be selected according to the nature of the sample to analyse.

Abstract: An improved, affordable, and rapid fluid mixture composition or process monitor based on a thermal microstructure sensor. This is preferably accomplished with a microbridge sensor design that has reduced susceptibility to interfering components of the mixture. The sensor described herein is therefore suitable for monitoring the concentration of at least one component in a fluid mixture when the fluid mixture consists of either (1) two components with very different thermal conductivities; or (2) three or more components wherein at least one component has a very different thermal conductivity and the effects of the other components can be largely eliminated, especially if the component of interest is hydrogen and the interference is from the variability in the concentrations of CO2 and H2O.

Abstract: A clinical test apparatus includes a reaction table (1) for placing a test piece thereon for reaction of the test piece with an analyte at a predetermined temperature to perform analysis. The clinical test apparatus includes a primary coil (3) fixed, as molded and sealed in resin, on a base facing the reverse surface of the reaction table (1) and supplied with alternating power, a secondary coil (4) mounted, as molded and sealed in resin, on the reverse surface of the reaction table (1) in facing relation to the primary coil (3) for inducing an electromotive force due to the alternating power supplied to the primary coil and a heater (5) built in the reaction table (1) for generating heat due to the electromotive force induced in the secondary coil.

Abstract: A multiple parallel catalytic reactor assembly has been developed. The assembly has (1) a plurality of vessels for containing catalyst, each vessel having an open end and a fluid permeable end (2) a plurality of bottoms, each bottom having an open end and a closed end with the plurality being supported by a single first support plurality of vessels positioned within the plurality of bottoms; (3) a plurality of tops supported by a single second support with the plurality of tops engaged with the plurality of bottoms to form a plurality of sealed independent reaction chambers; (4) a plurality of first fluid conduits in fluid communication with the reaction chambers, and (5) a plurality of second fluid conduits in fluid communication with the reaction chambers.

Abstract: There is disclosed a material characterization method. The method may include any combination of several potential steps. According to one of the steps multiple material samples are applied to multiple sensors in an array of sensors. In another step, one or more of the sensors of the array are electrically contacted. In another step, electrical connections are formed between selected sensors and electronic test and measurement apparatus. In another step, electric signals are sent to and received from the sensors in the array wherein the signals correspond to thermal, electrical, mechanical or other properties of the material samples. Preferably, some of the equipment (e.g., the electrical connections) used in the method are standardized to allow equipment such as sensor arrays to be interchangeable with equipment such as the electronic test and measurement apparatus.

Abstract: The invention is a system for the transport of products at a consistent temperature by use of a protective container for fragile products, specifically a container that protects and transports blood and medical products, with properties described in the detailed description section of this patent application.

Abstract: A modular materials characterization apparatus includes a sensor array disposed on a substrate, with a standardized array and contact pad format; electronic test and measurement apparatus for sending electrical signals to and receiving electrical signals from the sensor array; an apparatus for making electrical contact to the sensors in the standardized array format; an apparatus for routing signals between one or more selected sensors and the electronic test and measurement apparatus and a computer including a computer readable having a computer program recorded therein for controlling the operator of the apparatus. The sensor array is preferably arranged in a standardized format used in combinatorial chemistry applications for rapid deposition of sample materials on the sensor array.

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

Abstract: A time-temperature indicator device comprises a polymeric layer having a first and second surface and a dye composition adhered to said first surface comprising a dye which diffuses into the polymeric layer as a result of a cumulative time-temperature exposure wherein the polymeric layer is formed from a natural or synthetic rubber polymer or copolymer. The device may be attached to a product for monitoring cumulative time-temperature exposure.

Abstract: A vaporizer (14) supplies hydrogen peroxide and water vapor to a high level disinfection or sterilization region (20). Mid-infrared light detectors (32) detect light in the mid-infrared range which has traversed a region of the treatment chamber in a first narrow spectrum centered at 8,000 nanometers which is absorbed by the hydrogen peroxide vapor, a second narrow spectrum which is absorbed by the water vapor, and a third spectrum that is absorbed by neither the hydrogen peroxide vapor nor the water vapor. From these measurements, an absorbance or transmittance is determined (40) from which the concentrations of hydrogen peroxide and water vapor are determined (42). Monitored temperature (44) and the determined concentrations are converted into a percent saturation (54). The supply of hydrogen peroxide and water vapor to the chamber is controlled (60) in accordance with the determined percent saturation.

Abstract: An apparatus for monitoring the concentration of an oxidative gas or vapor includes a chemical substance which reacts with the oxidative gas or vapor to produce a heat change. A temperature probe is coupled to the chemical substance and adapted to respond to the heat change. The temperature probe can be coupled to the chemical substance by a carrier, and can include a reference temperature probe. Additionally, a method of using the apparatus is described, as well as a sterilization system which utilizes the apparatus.

Abstract: A reaction vessel has a reaction chamber, a loading reservoir connected to the reaction chamber via a first channel, and an aspiration port connected to the chamber via a second channel. To load the sample into the reaction chamber, the sample is dispensed into the loading reservoir and then drawn into the chamber by application of a vacuum to the aspiration port. A system for controlling the temperature of the sample in the reaction vessel includes one or more thermal elements for heating or cooling the sample and optionally optics for detecting one or more analytes in the sample.

Abstract: Apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical devices. The methods include measurement strategies and data processing techniques for reducing noise in measurements of thermal processes. The apparatus and methods may be particularly suitable for extracting thermal data from small differential measurements made using an infrared camera and for monitoring chemical and physiological processes.

Abstract: The present invention relates to a modular analyzer system for the analysis of at least two or more chemical components contained in pickle liquor solution. The analyzer modules include a strong acid analysis module, a weak acid analysis module, an oxidizer analysis module, and a metal ion analysis module. These four modules may be used in any combination, including the use of more than one of the same type of analysis module.

Abstract: A monitor of the concentration of an oxidative gas or vapor comprises a chemical coupled to a temperature probe, such as by a carrier. Addtionally, the monitor is used in a method of monitoring the concentration of an oxidative gas or vapor and in a sterilization system operated by a user. By utilizing an output signal from the temperature probe to measure the heat produced in an exothermic reaction between the monitored oxidative gas or vapor and the chemical of the monitor, the concentration of the monitored oxidative gas or vapor can be determined. The present invention represents an improvement over the monitors described in the prior art since it is more simplified, and can provide information on the local concentration of an oxidative gas or vapor at various positions within a chamber, and can be operated in size-restricted volumes. Additionally, a method of using the monitor is described, as well as a sterilization system which utilizes the monitor.

Abstract: A sensor is provided that includes at least one functional coating layer that includes a UV-absorbing polymer. Methods for making the inventive sensors are also provided.

Abstract: The invention provides a reaction vessel and temperature control system for performing heat-exchanging chemical reactions, such as nucleic acid amplification. The vessel has a body defining a reaction chamber, and a loading structure extending from the body for loading a sample into the chamber. The loading structure has a loading reservoir, an aspiration port, and respective fluid channels connecting the loading reservoir and aspiration port to the chamber. To load the sample into the vessel, the sample is first dispensed into the loading reservoir and then drawn into the chamber by application of a vacuum to the aspiration port. The vessel also includes a seal aperture extending over the outer ends of the loading reservoir and aspiration port. A plug is inserted into the aperture after loading the sample into the chamber to simultaneously seal the chamber, loading reservoir, and aspiration port from the external environment.

Abstract: A method of detecting locations on a nucleic acid probe array at which hybridization occurs between targets in a fluid sample and nucleic acid probes disposed on a surface of the nucleic acid probe array, comprising: measuring the temperature at a plurality of locations on the surface of the nucleic acid probe array; applying an oscillating level of energy to the surface of the nucleic acid probe array, thereby causing the temperature at the surface of the nucleic acid probe array to oscillate; and detecting a decreased range of temperature oscillation at least one of the plurality of locations on the nucleic acid probe array, thereby indicating an increased heat capacity caused by latent heat of hybridization between at least one target in the fluid sample and at least one nucleic acid probe disposed on a surface of the nucleic acid probe array.

Abstract: An apparatus for detecting physical abnormalities in milk which comprises a light source for irradiating milk with light of red or green or blue colors or any combination of such colors. The intensity of light reflected or diffused or transmitted, or any combination thereof, by the milk, or from background light of the milk, is measured by light sensors. A computer processes the measurement data and is programmed to select, based on comparisons of the values derived from the measured light intensities with reference values, a diagnostic basis or diagnostic bases for abnormalities in the milk from a plurality of diagnostic bases of possible abnormalities stored in the memory of the computer.

Abstract: A reactor for conducting catalytic chemical reactions has been developed. The reactor has a well having an open end and a closed end. The reactor also has a sleeve having a top end and a bottom end. The bottom end of the sleeve is inserted within the open end of the well. A fluid permeable structure is attached to the sleeve spanning the cross-section thereby defining a chamber between the closed end of the well and the fluid permeable structure. The reactor also has a reactor insert having a fluid permeable end and a top end containing a first and a second fluid conduit. The fluid permeable end of the reactor is inserted within the open end of the sleeve. The first fluid conduit is in fluid communication with the chamber, and the second fluid conduit is in fluid communication with the fluid permeable end of the reactor insert.

Abstract: The invention provides a temperature probe comprising an inlet end opposed to an outlet end; a flow-directing passage defined by a wall; the wall, the inlet end, and the outlet end configured to define a longitudinal axis; a strut attached to the wall at an attachment site, and a temperature sensor located at the distal tip of the strut to position the sensor in the flow of fluid along the longitudinal axis through the passage, wherein the distance from the inlet end to the sensor is less than the distance from the inlet end to the attachment site.

Abstract: Apparatus and methods for automatically staining or treating multiple tissue samples mounted on microscope slides are provided. Individualized slide temperature control is accomplished by the heating system according to the present invention that has thermal platforms radially mounted to the carousel for heating the slides and sensing the temperature of each. The heating system also permits automated de-waxing if necessary.

Abstract: A fluid sampling device including a manifold having inputs, common purge and sampling pathways, valves disposed to couple and decouple a first set of the inputs to the common purge pathway and a second set of the inputs to the common sampling pathway, and a differential sensor coupled to the pathways. A controller connected to the valves produces control signals that enable the valves to couple and decouple the inputs to the common sensor and purge pathways. In addition, a method for operating a fluid sampling system that is connected to a set of sample zones that includes the steps of sampling fluid from first and second sample zones in respective first and second sample locations, isolating third and fourth sample zones from the first and second sample locations, and measuring a differential parameter across the sample locations.

Abstract: A biosensor in which a carbohydrate or a derivative of a carbohydrate is used to generate a detectable signal by way of the specific binding to a protein, a virus or a cell.