Orthophosphate (e.g., Calcium Hydroxyapatite) Patents (Class 423/308)
  • Patent number: 10906029
    Abstract: Provided is a photocatalyst including a photocatalyst in which part of calcium ions are substituted with titanium ions, and part of phosphoric acid ions are substituted with metal oxoacid ions in a calcium hydroxyapatite crystal structure.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: February 2, 2021
    Assignees: FUJITSU LIMITED, TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Masato Wakamura, Akira Nakajima, Noppakhate Jiraborvornpongsa
  • Patent number: 10793847
    Abstract: The present invention provides a method, wherein the method forms a biofilm, wherein the biofilm comprises a population of at least one bacterial strain attached to particles, wherein the biofilm is configured to colonize a gut of a subject in need thereof for at least five days, when ingested by the subject, the method comprising: a. obtaining a population comprising at least one strain of bacteria; b. inoculating a growth medium containing particles with the population comprising at least one strain of bacteria; c. incubating the particles with the population comprising at least one bacterial strain for a time sufficient for the population of at least one strain of bacteria to attach to the particles; and d. culturing the population comprising at least one strain of bacteria attached to the particles in a growth medium, for a time sufficient to form a biofilm.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: October 6, 2020
    Assignee: MYBIOTICS PHARMA LTD.
    Inventors: David Baram, Rachel Diamant, David Daboush
  • Patent number: 10385216
    Abstract: The present invention relates to dispersion of surface modified inorganic particles including (a) fluid comprising a complexing agent, and (b) the surface modified inorganic particles comprising polyvalent metal ions.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: August 20, 2019
    Assignee: GRACE GMBH
    Inventor: Timothy Edward Fletcher
  • Patent number: 10363553
    Abstract: A photocatalytic nanocomposite hollow sphere comprising a shell surrounding a hollow core, and the shell comprising zirconium dioxide, hydroxyapatite, and platinum, as well as a method for producing the nanocomposite hollow sphere and a method employing the nanocomposite hollow sphere in reducing an aromatic nitro compound to an aromatic amine compound under visible light are disclosed.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: July 30, 2019
    Assignee: King Abdulaziz University
    Inventors: Mohammad W. Kadi, Reda Mohamedy Mohamed Ouf
  • Patent number: 10329327
    Abstract: The invention is directed to a composition comprising all or a portion of a beta-tricalcium phosphate (?-TCP) bound to all or a portion of a ?-TCP binding peptide and methods of use thereof.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: June 25, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Luis Alvarez, Linda G. Griffith, Yadir Guerrero, Linda Stockdale, Jaime Rivera
  • Patent number: 9896741
    Abstract: A method of producing a metal carbonate from an ultramafic rock material is provided. The method includes providing an ultramafic rock material comprising a metal silicate; reacting the ultramafic rock material with an acid to form a mixture comprising a salt of the metal; contacting the mixture comprising a salt of the metal with oxygen so as to aerate impurities in the mixture and/or to remove residual acid from the mixture; heating the resultant mixture to decompose the salt of the metal to form metal oxide; and reacting the metal oxide with aqueous ammonium carbonate to obtain the metal carbonate. A system for producing a metal carbonate from ultramafic rock material is also provided.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: February 20, 2018
    Assignee: Agency for Science, Technology and Research
    Inventors: Jie Bu, Tze Yuen Yeo, Paul Sharratt
  • Patent number: 9795543
    Abstract: The invention relates to nano-sized complexes formed by associating amorphous calcium phosphate (ACP) and/or amorphous calcium fluoride phosphate (ACFP) with an amphiphilic polymer surfactant. The amphiphilic polymer surfactants can form nano-sized assemblies in aqueous solution, serving as a nano dispersant preventing ACP and/or ACFP from aggregation, and as a nano carrier associating or attaching ACP and/or ACFP, stabilizing ACP and/or ACFP against the conversion to a crystalline form as well, thus maintaining calcium and phosphate/and fluoride ions in a bioavailable state for dental re-mineralization and prevention of dental caries, dental calculus and dental hyper-sensitivity. A method for the nano-sized complex preparation and compositions comprising the nano-sized complexes are also provided.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: October 24, 2017
    Assignee: PAC-DENT INTERNATIONAL INC.
    Inventors: Susan Jiao, Daniel Wang, Bo Tao, Xiao Yang
  • Patent number: 9676665
    Abstract: Refrigerated hydraulic cement compositions comprise a mixture of (a) ?-tricalcium phosphate powder, (b) monocalcium phosphate comprising monocalcium phosphate anhydrous (MCPA), monocalcium phosphate monohydrate (MCPM), or a combination thereof, wherein a 0.1 g/ml saturated aqueous solution of the monocalcium phosphate has a pH less than 3.0, (c) non-aqueous water-miscible liquid, and (d) an aqueous hydrating liquid. The aqueous hydrating liquid is included in an amount of about 1-50 volume percent, based on the combined volume of the non-aqueous water-miscible liquid and the aqueous hydration liquid, and the refrigerated hydraulic cement composition is storage stable for greater than one day, without setting. Methods of forming hardened cements in vivo and/or for forming implants for use in vivo employ the hydraulic cement compositions.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: June 13, 2017
    Assignee: OSSDSIGN AB
    Inventors: Håkan Engqvist, Jonas Aberg
  • Patent number: 9592540
    Abstract: The present invention discloses methods of neutralizing apatite surfaces, for example after a flow-through collection of a target and prior to cleaning the chromatography solid support.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: March 14, 2017
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Larry J. Cummings
  • Publication number: 20150133292
    Abstract: An apatite compound represented by general formula: A10(PO4)6(OH)2 (wherein A represents Ba or a combination of Ba and Sr and/or Ca) is used as a carrier. This exhaust gas purifying catalyst is obtained by having the apatite compound carrier support a noble metal component.
    Type: Application
    Filed: May 17, 2012
    Publication date: May 14, 2015
    Inventors: Shinichi Nakata, Sumio Kato, Masataka Ogasawara, Atsunori Ono, Yohei Takahashi, Takashi Wakabayashi, Yunosuke Nakahara
  • Publication number: 20150125808
    Abstract: An apparatus for mineralising a biological material includes an ultrasonic source, operable to generate an ultrasonic signal, an ultrasonic probe and one or more mineralising probes, operable to receive a mineralising agent. The mineralising agent is transferred from at least one mineralising probe to the biological material using the ultrasonic signal. Also disclosed are a mineralisation agent and a method of mineralising a biological material that includes the steps of: providing an ultrasound source, providing a mineralising agent, generating an ultrasonic signal from the ultrasound source, and applying the ultrasonic signal and the mineralising agent to the biological material separately, sequentially or simultaneously.
    Type: Application
    Filed: January 9, 2015
    Publication date: May 7, 2015
    Inventors: Nigel Pitts, Christopher Longbottom, Joseph Crayston
  • Patent number: 8999366
    Abstract: The present invention provides a synthetic non-resorbable silicon-containing calcium phosphate biomaterial having a microporosity of 23% by volume or greater, wherein the surface free energy of the biomaterial is 19 mJ/m.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: April 7, 2015
    Assignee: ApaTech Limited
    Inventors: Thomas Buckland, Charles Campion
  • Patent number: 8956595
    Abstract: Calcium peroxyphosphate compounds and dental compositions comprising these compounds that combine both whitening/stain removal of teeth with remineralization are disclosed. The calcium peroxyphosphate compounds are capable of releasing, in an aqueous environment, whitening and remineralization effective amounts of calcium ion, phosphate ion, and active oxygen. Preferred compounds are calcium peroxymonophosphate or calcium diperoxymonophosphate compounds. These compounds may be used in humans and other animals, including other mammals.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: February 17, 2015
    Assignee: ADA Foundation
    Inventor: Ming S. Tung
  • Patent number: 8916311
    Abstract: A c-axis-oriented HAP thin film synthesized by seeded growth on a palladium hydrogen membrane substrate. An exemplary synthetic process includes electrochemical seeding on the substrate, and secondary and tertiary hydrothermal treatments under conditions that favor growth along c-axes and a-axes in sequence. By adjusting corresponding synthetic conditions, an HAP this film can be grown to a controllable thickness with a dense coverage on the underlying substrate. The thin films have relatively high proton conductivity under hydrogen atmosphere and high temperature conditions. The c-axis oriented films may be integrated into fuel cells for application in the intermediate temperature range of 200-600° C. The electrochemical-hydrothermal deposition technique may be applied to create other oriented crystal materials having optimized properties, useful for separations and catalysis as well as electronic and electrochemical applications, electrochemical membrane reactors, and in chemical sensors.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: December 23, 2014
    Assignee: University of Rochester
    Inventors: Matthew Yates, Wei Xue
  • Patent number: 8882903
    Abstract: The present invention provides white pigments of crystalline aluminum orthophosphate dihydrate, their use as white pigment in paints and also processes for their production.
    Type: Grant
    Filed: June 28, 2008
    Date of Patent: November 11, 2014
    Assignee: BK Giulini GmbH
    Inventors: Henrike Thauern, Michael Schmitt, Thomas Staffel
  • Patent number: 8871167
    Abstract: A hydroxyapatite ceramic hybrid material, which includes a biodegradable polymer included in the pores in a hydroxyapatite ceramic structure, and a method thereof, and a calcium phosphate porous body, which is formed by an intertwining of fibrous calcium phosphates and includes a plurality of first pores formed where the fibrous calcium phosphates interconnect and plurality of equal diameter substantially spherical second pores with a larger inside diameter than the first pores, and a method thereof are provided.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: October 28, 2014
    Assignees: Meiji University, Showa Ika Kogyo Co. Ltd.
    Inventors: Mamoru Aizawa, Masahiro Rikukawa, Yusuke Shigemitsu, Hiroshi Nagashima
  • Patent number: 8846563
    Abstract: The present invention relates to apatite that includes metal atoms having a photocatalytic function and other metal atoms, and the metal atoms having a photocatalytic function include metal atoms that absorb energy corresponding to light energy of visible light. By applying the apatite as a base material of various products to be arranged indoors, the photocatalytic function can be exhibited indoors as well.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: September 30, 2014
    Assignees: Fujitsu Limited, The University of Tokyo
    Inventors: Toshiya Watanabe, Masato Wakamura, Yasuo Naganuma
  • Patent number: 8821163
    Abstract: Colorless dental compositions for restoring the enamel layer of a tooth are disclosed. The colorless enamel compositions are combined with pigmented dentin compositions to provide a true color match and natural esthetics. Methods that utilize the compositions in placement/build-up techniques in direct restorations are also disclosed.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: September 2, 2014
    Assignee: Ivoclar Vivadent, Inc.
    Inventor: Terry Lee Culp
  • Publication number: 20140206614
    Abstract: Compositions and methods of using the compositions are provided for forming an embolus within a region of an anatomical lumen for a transitory period in order to achieve a therapeutic effect.
    Type: Application
    Filed: March 20, 2014
    Publication date: July 24, 2014
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Wouter E. Roorda, Stephen D. Pacetti
  • Patent number: 8753601
    Abstract: Described is a method for the production of metal salts, wherein the cationic metal is preferably selected from Group I to IV metals and mixtures thereof and the anionic group is selected from phosphates, silicates, sulfates, carbonates, hydroxides, fluorides and mixtures thereof, and wherein said method comprises forming a mixture of at least one metal source that is a metal carboxylate with a mean carbon value per carboxylate group of at least 3 and at least one anion source into droplets and oxiding said droplets in a high temperature environment, preferably a flame. This method is especially suited for the production of calcium phosphate biomaterials such as hydroxyapatite (HAp,Ca10(PO4)6(OH)2) and tricalcium phosphate (TCP,Ca3(PO4)2) that exhibit excellent biocompatibility and osteoconductivity and therefore are widely used for reparation of bony or periodontal defects, coating of metallic implants and bone space fillers.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: June 17, 2014
    Assignee: Eidgenossische Technische Hochschule Zurich
    Inventors: Wendelin Jan Stark, Sotiris-Emmanuel Pratsinis, Marek Maciejewski, Stefan Fridolin Loher, Alfons Baiker
  • Patent number: 8728536
    Abstract: A method and composition are provided for treating cancer in a mammal. The method includes administering to a tumor site of the mammal an anticancer composition comprising a mixture of an anticancer agent and a nanocrystalline or poorly crystalline calcium phosphate paste, said paste comprised of one or more calcium phosphates and a physiologically acceptable fluid, the paste having an injectable or formable consistency at the time of administration and hardenable at the tumor.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: May 20, 2014
    Assignee: Etex Corporation
    Inventor: Maria Aiolova
  • Patent number: 8673252
    Abstract: A method for preparing nanoscale hydroxyapatite particles by combining an amount of a calcium ion source, which includes calcium acetate, and an amount of a phosphate ion source, wherein the amounts are sufficient to produce nanoscale hydroxyapatite particles and the amounts are combined under ambient conditions to produce the hydroxyapatite particles. Nanoscale hydroxyapatite particles are also presented.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: March 18, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Richard E. Riman, Christina Sever
  • Patent number: 8673017
    Abstract: The object of the present invention is a process for obtaining a bone substitute of given chemical and physical characteristics and entirely similar to those of the mineral portion of natural bone tissue. The process substitutes Ca ions with Mg ions in a porous matrix; the process comprises a phase of contacting the matrix with a saline aqueous solution containing an effective quantity of Mg ions at a pressure greater than or equal to 1 bar.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: March 18, 2014
    Assignee: Fin-Ceramica Faenza S.p.A.
    Inventors: Roberta Martinetti, Daniele Pressato, Laura Dolcini, Sergio Di Fede
  • Publication number: 20140066359
    Abstract: According to a first aspect, hydrolysis of a protein-containing raw material and separation of amino acids/peptides is carried out, wherein the hydrolysis is effected by using the endogenous enzymes of the protein-containing raw material. The hydrolysate is passed through a membrane filter, wherein peptide/amino acids follow a permeate stream, whilst the active enzymes continuously break down any protein residues that are deposited on the membrane surface. The enzymes are passed together with retentate back to the hydrolysis. Furthermore, an amino acid and peptide product and an oil product are described and the use thereof is disclosed.
    Type: Application
    Filed: November 10, 2013
    Publication date: March 6, 2014
    Applicant: Zymtech Production AS
    Inventor: Tomas Carlsson
  • Patent number: 8658117
    Abstract: A method for production of ammonium phosphates includes providing (210) of a phosphorus-loaded water immiscible liquid phase, adding (212) of anhydrous ammonia to the water immiscible liquid phase, precipitating (214) of mono-ammonium phosphate and/or di-ammonium phosphate from the water immiscible liquid phase and extracting (218) of the precipitated mono-ammonium phosphate and/or di-ammonium phosphate from the water immiscible liquid phase. The method further includes controlling (216) of a temperature of the water immiscible liquid phase during the adding (212) and precipitating (214) to a predetermined temperature interval.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: February 25, 2014
    Assignee: EasyMining Sweden AB
    Inventor: Yariv Cohen
  • Publication number: 20130323812
    Abstract: Methods and compositions are provided for treatment of an apatite-based resin from which retained solutes have been eluted by an elution buffer that contains an alkali metal salt with solutions of calcium ion, phosphate ion, and hydroxide separately from any sample loading and elution buffers. The treatment solutions restore the resin, reversing the deterioration that is caused by the alkali metal salt in the elution buffer.
    Type: Application
    Filed: May 10, 2013
    Publication date: December 5, 2013
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Larry J. Cummings, Jie He
  • Patent number: 8597604
    Abstract: Methods for the synthesis of tricalcium phosphates are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the tricalcium phosphate precursor precipitate. Particulate tricalcium phosphate compositions having an average crystal size of about 250 nm or less are provided. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: December 3, 2013
    Assignee: Pioneer Surgical Technology, Inc.
    Inventor: Edward S. Ahn
  • Patent number: 8597718
    Abstract: An ultrathin film of calcium phosphate crystals having a thickness of 200 nm or less on a surface of a solid substrate, and a method for preparing the same are disclosed. Further, an amorphous dendritic extension used as an intermediate material in preparation of the ultrathin film of calcium phosphate and a method for forming the same are disclosed. The ultrathin film of calcium phosphate crystals can be coated on the surface of the solid substrate while substantially maintaining surface roughness of the solid substrate. The method employs calcium phosphate ion solutions at low temperature.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: December 3, 2013
    Assignee: Seoul National University Industry Foundation
    Inventor: Hyun Man Kim
  • Patent number: 8545895
    Abstract: An inorganic silicate-substituted calcium phosphate hydroxyapatite, useful as a biomaterial, has a Ca/P molar ratio in the range 2.05 to 2.55 and a Ca/(P+Si) molar ratio less than 1.66. The hydroxyapatite can be substantially free of carbonate ions. The material has relatively high solubility and is able to release silicon into solution.
    Type: Grant
    Filed: January 5, 2010
    Date of Patent: October 1, 2013
    Assignee: The University Court of the University of Aberdeen
    Inventors: Iain Ronald Gibson, Janet Mabel Scott Skakle
  • Publication number: 20130236856
    Abstract: Provided are a hard tissue restoration material, which is excellent in hard tissue restoration ability, extremely effective in promoting recalcification of dental enamel, and excellent in protection properties and aesthetic properties, and a hard tissue restoration method. The hard tissue restoration material according to the present invention is a biocompatible ceramic film with flexibility and pliability that is obtained, for example, by immersing a substrate, having the biocompatible ceramic film formed thereon, in a solvent, which does not dissolve the biocompatible ceramic but dissolves at least a portion of the substrate, to dissolve or separate the substrate. Also, with the hard tissue restoration method according to the present invention, the hard tissue restoration material according to the present invention is bonded to or wound around a hard tissue defect site.
    Type: Application
    Filed: January 29, 2013
    Publication date: September 12, 2013
    Applicant: KINKI UNIVERSITY
    Inventors: Shigeki HONTSU, Hiroaki NISHIKAWA, Masanobu KUSUNOKI, Kazushi YOSHIKAWA, Kazuyo YAMAMOTO
  • Patent number: 8529859
    Abstract: The present invention provides a method of crystallizing Yb:C-FAP [Yb3+:Ca5(PO4)3F], by dissolving the Yb:C-FAP in an acidic solution, following by neutralizing the solution. The present invention also provides a method of forming crystalline Yb:C-FAP by dissolving the component ingredients in an acidic solution, followed by forming a supersaturated solution.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: September 10, 2013
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Thomas F. Soules, Kathleen I. Schaffers, John B. Tassano, Jr., Joel P. Hollingsworth
  • Patent number: 8414857
    Abstract: The invention concerns calcium phosphates in granular form having an x-ray diffraction pattern characteristic of hydroxyapatite and good compressibility and flow properties in direct compression applications. The invention also concerns the method for preparing said granules characterized in that it comprises processing a suspension of brushite dicalcium phosphate having a certain particle-size distribution using a basic solution, and maintaining the pH at not less than 7.0 for a sufficient time interval to enable the transformation of the brushite calcium phosphate into hydroxyapatite calcium phosphate.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: April 9, 2013
    Assignee: Innophos, Inc.
    Inventors: John Godber, Lorraine Leite
  • Patent number: 8409538
    Abstract: Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: April 2, 2013
    Assignee: Skeletal Kinetics LLC
    Inventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
  • Patent number: 8404876
    Abstract: A process comprises (a) combining (1) at least one metal cation source, (2) at least one phosphate anion source, (3) at least one organic base comprising at least one organic moiety comprising at least about five carbon atoms, and (4) at least one organosilane comprising at least one organic moiety comprising at least about six carbon atoms; and (b) allowing the metal cation source and the phosphate anion source to react in the presence of the organic base and the organosilane (for example, to form surface-modified metal phosphate nanoparticles).
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: March 26, 2013
    Assignee: 3M Innovative Properties Company
    Inventors: Neeraj Sharma, Choua C. Vu
  • Publication number: 20130022527
    Abstract: A method for preparing nanoscale hydroxyapatite particles by combining an amount of a calcium ion source, which includes calcium acetate, and an amount of a phosphate ion source, wherein the amounts are sufficient to produce nanoscale hydroxyapatite particles and the amounts are combined under ambient conditions to produce the hydroxyapatite particles. Nanoscale hydroxyapatite particles are also presented.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 24, 2013
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Richard Riman, Christina Sever
  • Patent number: 8357732
    Abstract: A method of synthesizing hydroxyapatite nanorods, having high purity, high crystallinity and high aspect ratio is disclosed here. In one embodiment, high crystalline hydroxyapatite nanorods with relatively stoichiometric structure are prepared via hydrothermal method at 200° C. and under moderate acidic conditions. The synthesized hydroxyapatite nanorods have a diameter of 30-95 nm, a length of 850-1400 nm with an average aspect ratio of 24, degree of crystallinity of 73% and stoichiometry ratio of 1.69. Further it discloses the use of HAp in dental adhesive. The dental adhesive comprising synthesized HAp shows improved diametral tensile strength and high microshear bond strength. Energy dispersive X-ray mapping confirmed the uniform distribution of nanorods in the adhesive matrix. The synthesized hydroxyapatite nanorods have high colloidal stability in the dental adhesive solution.
    Type: Grant
    Filed: March 14, 2010
    Date of Patent: January 22, 2013
    Inventors: Mehdi Sadat-Shojai, Mohammad Atai, Azizollah Nodehi
  • Publication number: 20130005642
    Abstract: According to a first aspect, hydrolysis of a protein-containing raw material and separation of amino acids/peptides is carried out, wherein the hydrolysis is effected by using the endogenous enzymes of the protein-containing raw material. The hydrolysate is passed through a membrane filter, wherein peptide/amino acids follow a permeate stream, whilst the active enzymes continuously break down any protein residues that are deposited on the membrane surface. The enzymes are passed together with retentate back to the hydrolysis. Furthermore, an amino acid and peptide product and an oil product are described and the use thereof is disclosed.
    Type: Application
    Filed: January 23, 2012
    Publication date: January 3, 2013
    Applicant: Zymtech Production AS
    Inventor: Tomas Carlsson
  • Publication number: 20120285880
    Abstract: The present invention provides that powder is mainly constituted from secondary particles of hydroxyapatite. The secondary particles are obtained by drying a slurry containing primary particles of hydroxyapatite and aggregates thereof and granulating the primary particles and the aggregates. A bulk density of the powder is 0.65 g/mL or more and a specific surface area of the secondary particles is 70 m2/g or more. The powder of the present invention has high strength and is capable of exhibiting superior adsorption capability when it is used for an adsorbent an adsorption apparatus has.
    Type: Application
    Filed: September 22, 2010
    Publication date: November 15, 2012
    Applicant: HOYA CORPORATION
    Inventor: Shintaro Kobayashi
  • Publication number: 20120265152
    Abstract: The invention relates to a hydroxylapatite material, for the production of which a nanoscale hydroxylapatite paste is subjected to a thermal treatment.
    Type: Application
    Filed: September 2, 2010
    Publication date: October 18, 2012
    Inventors: Elvira Dingeldein, Lydia Heimann, Georgiana Gasqueres, Marco Wolfstadter
  • Patent number: 8268278
    Abstract: Phosphorus-calcium-strontium compound of formula (I); method for preparing same; composition for the extemporaneous preparation of a cement comprising a solid phase (SP) and a liquid phase (LP), wherein the solid phase comprises a mixture of inorganic compounds of formula (II); use as an endodontic cement.
    Type: Grant
    Filed: July 9, 2007
    Date of Patent: September 18, 2012
    Assignees: Centre National de la Recherche Scientifique, Universite de Montpellier I
    Inventors: Philippe Boudeville, Pierre Michailesco, Emmanuel Castany, Michel René Vert
  • Patent number: 8246924
    Abstract: The present application is directed to methods of manufacturing calcium phosphate particles. In particular, the method is directed at eliminating the requirement for a sintering step in the manufacturing process. The method involves the atomization and combustion of one or more antecedent compositions containing calcium precursors, phosphorus precursors and hydrogen peroxide.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: August 21, 2012
    Assignee: HKPB Scientific Limited
    Inventor: Donncha Haverty
  • Patent number: 8246736
    Abstract: Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: August 21, 2012
    Assignee: Skeletal Kinetics, LLC
    Inventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
  • Publication number: 20120165577
    Abstract: Catalytic processes to produce a reaction product comprising 1-butanol by contacting a reactant comprising ethanol with a catalyst composition under suitable reaction conditions are provided. The catalyst composition may comprise a hydroxyapatite of the Formula (MwM?xM?yM??z)5(PO4)3(OH), wherein M is Mg; M? is Ca; M? is Sr; M?? is Ba; w is any number between 0 and 1 inclusive; x is any number from 0 to less than 0.5; y is any number between 0 and 1 inclusive; z is any number between 0 and 1 inclusive; and w+x+y+z=1. Base-treated catalyst compositions may be used. Also provided are processes for contacting an initial catalyst composition comprising the hydroxyapatite with a base to produce a base-treated catalyst composition, and the base-treated catalyst compositions so obtained.
    Type: Application
    Filed: September 10, 2010
    Publication date: June 28, 2012
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Paul Joseph Fagan, Thomas G. Calvarese, Ronald James Davis, Ronnie Ozer
  • Publication number: 20120149919
    Abstract: A process for preparing a vanadium, phosphorus, and oxygen comprising catalyst precursor for preparing maleic anhydride by heterogeneously catalyzed gas-phase oxidation of a hydrocarbon having at least four carbon atoms, which comprises (a) reacting vanadium pentoxide with 102% to 110% strength phosphoric acid in the presence of isobutanol and optionally of a primary or secondary, noncyclic or cyclic, unbranched or branched, saturated alcohol having 3 to 6 carbon atoms in a temperature range from 80 to 160° C.; (b) isolating the precipitate formed; (c) (i) drying the isolated precipitate down to a residual isobutanol content of less than 5% by weight; (ii) then passing a gas which in addition to one or more inert gases comprises 0.1% to 9% by volume of oxygen through the dried precipitate, directly or after isolation, in the temperature range from 130° C. to 200° C.
    Type: Application
    Filed: August 23, 2010
    Publication date: June 14, 2012
    Applicant: BASF SE
    Inventors: Stefan Altwasser, Cornelia Katharina Dobner, Hagen Wilmer, Frank Rosowski
  • Publication number: 20120136088
    Abstract: A hydroxyapatite ceramic hybrid material, which includes a biodegradable polymer included in the pores in a hydroxyapatite ceramic structure, and a method thereof, and a calcium phosphate porous body, which is formed by an intertwining of fibrous calcium phosphates and includes a plurality of first pores formed where the fibrous calcium phosphates interconnect and plurality of equal diameter substantially spherical second pores with a larger inside diameter than the first pores, and a method thereof are provided.
    Type: Application
    Filed: November 30, 2011
    Publication date: May 31, 2012
    Applicants: SHOWA-IKA KOGYO CO. LTD., MEIJI UNIVERSITY
    Inventors: Mamoru Aizawa, Masahiro Rikukawa, Yusuke Shigemitsu, Hiroshi Nagashima
  • Publication number: 20120128788
    Abstract: A collagen production enhancer for increasing the amount of collagen contained in the skin tissues, comprising calcium phosphate fine particles as effective ingredients.
    Type: Application
    Filed: May 26, 2009
    Publication date: May 24, 2012
    Applicant: SOFSERA CORPORATION
    Inventors: Yasumichi Kogai, Kazushige Karl Kawabe
  • Patent number: 8178066
    Abstract: The present invention provides a method for stabilizing fine particles of calcium phosphates without lowering their solid phase forming activity. It is possible to stabilize the fine particles of calcium phosphates by stopping the growth of the fine particles formed in an aqueous solution supersaturated with respect to calcium phosphates. More specifically, the fine particles of calcium phosphates were stabilized by lowering the inorganic ion concentration of a fine-particle-forming solution containing fine particles of calcium phosphates by dialysis, ion exchange, dilution, or the like, or by separating the fine particles of calcium phosphates from the fine-particle-forming solution by filtration, centrifuging, or the like.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: May 15, 2012
    Assignee: Kyoto University
    Inventors: Takeshi Yao, Mitsuhiro Hibino, Seiji Yamaguchi, Hidetaka Okada
  • Patent number: 8172939
    Abstract: A material for cement which comprises a calcium salt powder with an inositol phosphate and/or a salt thereof as adsorbed on the surface thereof, the powder having a specific surface area of 60-120 m2/g. A method of producing a material for cement comprises the step of mixing a calcium ion-containing solution adjusted to alkalinity with a phosphate ion-containing solution to produce a precipitate, the step of maturing the precipitate-containing system while maintaining the alkalinity to obtain a calcium salt powder, the step of recovering the calcium salt powder and drying the same, and the step of immersing the dried calcium salt powder in a solution containing an inositol phosphate and/or a salt thereof to cause the inositol phosphate and/or salt thereof to be adsorbed on the surface of the calcium salt powder.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: May 8, 2012
    Assignee: Meiji University
    Inventors: Mamoru Aizawa, Yukiko Horiguchi
  • Patent number: 8167995
    Abstract: A method is provided for making inexpensive synthetic inorganic resins that are stable, mix easily with water and may be conveniently diluted to form an easy-to-use paste for commercial applications. The method uses environmentally friendly techniques to provide improved efficiencies in the commercial production of these resins. The resins are produced by the partial reaction of phosphoric acid with sparsely-soluble oxides, or sparsely-soluble oxide minerals, that are added to the phosphoric acid under controlled conditions. In certain specific embodiments, methods are provided for modifying synthetic inorganic resins so as to produce rapid-setting phosphate cements and ceramics having high flexural strength. Unique synthetic inorganic resin formulations are also disclosed.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: May 1, 2012
    Assignee: Latitude 18, Inc.
    Inventor: Arun S. Wagh
  • Patent number: RE43661
    Abstract: Methods for synthesis of nanocrystalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having average crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m2/g and can be of high density. Hydroxy apatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: September 18, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Jackie Y. Ying, Edward S. Ahn, Atsuski Nakahira