Extract Or Material Containing Or Obtained From A Multicellular Fungus As Active Ingredient (e.g., Mushroom, Filamentous Fungus, Fungal Spore, Hyphae, Mycelium, Etc.) Patents (Class 424/195.15)
  • Patent number: 11058119
    Abstract: Entomopathogenic fungal strains, compositions, and methods of using the strains for reducing overall insect damage.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: July 13, 2021
    Inventors: Denny Joseph Bruck, Frederick C. Burns, II, James Kevin Presnail
  • Patent number: 10994001
    Abstract: The present invention relates to animals and more specifically to insects. In more details the invention relates to an edible composition or insect artificial diet comprising bacteria, fungi or any fragment or spore thereof for use as a vaccine in preventing a microbial disease or infection in an insect. Still, the present invention relates to preventive methods and different uses relating to said compositions or bacteria, fungi or fragments or spores thereof.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: May 4, 2021
    Assignee: Dalan Animal Health Inc.
    Inventors: Heli Salmela, Dalial Freitak
  • Patent number: 10987296
    Abstract: The present invention provides a composition and food for improving skin condition containing exopolysaccharides produced by Ceriporia lacerata, a mycelial culture fluid of Ceriporia lacerata comprising the exopolysaccharides, a dry powder of the mycelial culture fluid or an extract of the mycelial culture fluid as an active ingredient. The composition and the food for improving skin condition have a superior skin whitening effect, wrinkle improving effect, skin moisturizing effect or skin anti-aging effect.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: April 27, 2021
    Assignee: FUGENBIO CO., LTD.
    Inventor: Yoon Soo Kim
  • Patent number: 10925899
    Abstract: The present invention relates to a composition for the synthesis of ATP as an energy supplementation. The composition comprises a plant extract or a plant fraction suitable to produce ATP upon exposure to light. The present invention also relates to the isolation of such plant extract and to its use in energy drinks.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: February 23, 2021
    Inventors: Marc Purcell, Nathalie Miller
  • Patent number: 10889798
    Abstract: Described herein is a method for blastospore-based insect control products of entomopathogenic fungi including either B. bassiana or I. fumosorosea that produces high concentrations of stable, effective spores by identifying nutritional and environmental conditions required for the rapid production of high concentrations of a stable and infective yeast-like blastospore composition.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: January 12, 2021
    Assignees: The United States of America, as represented by The Secretary of Agriculture
    Inventors: Mark A. Jackson, Gabriel Moura, Mascarin
  • Patent number: 10813359
    Abstract: The invention provides a synthetic combination of a crop and at least one fungal endophyte, wherein the crop is a host plant of the endophyte. Provided are also methods and compositions for producing such synthetic combinations. The endophyte reproduces and enhances the agronomic characteristics of the crop. Methods for inoculating the host plant with the endophyte, for propagating the host-endophyte combination, and for detecting the presence of the endophyte and of its metabolites within a host plant are also described.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: October 27, 2020
    Assignee: THE TEXAS A & M UNIVERSITY SYSTEM
    Inventor: Gregory A. Sword
  • Patent number: 10806762
    Abstract: Disclosures of the present invention describe a method of treatment of cancer cells by using pharmaceutical composition. In the present invention, it particularly adopts an ethanol extract of Taiwanofungus camphorata (TCEE), an ethanol extract of Ganoderma lucidum (GLEE) or a combination of the TCEE and the GLEE as the a pharmaceutical composition for use in causing the apoptosis of lung cancer cells A594, hepatoma cells Huh 7, breast cancer cells MDA-MB 231, and colorectal cancer cells HT 29. Moreover, related experimental data have proved that, the pharmaceutical composition can not only be used for adjunctively treating cancer, but also possesses many healthy effects, including: detoxification, enhancing immunity, and increasing appetite.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: October 20, 2020
    Assignees: TAIWAN INDIGENA BOTANICA CO., LTD., TAIPEI MEDICAL UNIVERSITY
    Inventors: Ching-Hua Su, Cheng-Jeng Tai, Yeu-Ching Shi
  • Patent number: 10772920
    Abstract: The present invention relates to an extracellular polysaccharide produced by Ceriporia lacerata, a culture medium of Ceriporia lacerata hyphae including the extracellular polysaccharide, a composition for immunoregulation containing, as an active ingredient, dried powder of the hyphae culture medium or an extract of the hyphae culture medium, a pharmaceutical composition for preventing or treating an immune disease, and a health food for immunoregulation. The composition of the present invention has an excellent effect on immune enhancement and overactive immune response inhibition.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: September 15, 2020
    Assignee: FUGENBIO CO., LTD.
    Inventor: Yoon Soo Kim
  • Patent number: 10744084
    Abstract: A method is presented for treating herpes simplex virus (HSV) infection comprising: (a) locally administering a substance that induces a delayed type hypersensitivity (DTH) response to a patient at a site of an HSV lesion to induce a DTH response at the site of the lesion during one or more outbreaks of the HSV infection.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: August 18, 2020
    Assignees: Squarex, LLC, Bioventures, LLC
    Inventors: Hugh McTavish, Thomas Dag Horn, Sandra Marchese Johnson
  • Patent number: 10702564
    Abstract: The present invention relates to a blood pressure lowering composition which contains as an active ingredient exopolysaccharide produced by means of Ceriporia lacerata, a Ceriporia lacerata mycelium culture medium comprising same, or dry powder or an extract of same. The composition can be used as an antihypertensive for preventing or treating hypertension or cerebral apoplexy or as a functional health food having antihypertensive effect.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: July 7, 2020
    Assignee: FUGENBIOPHARMA CO., LTD.
    Inventor: Yoon Soo Kim
  • Patent number: 10660928
    Abstract: The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of Moutan Root Bark, Angelica Dahurica Root, and Bupleurum Root, or a fraction thereof.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: May 26, 2020
    Assignees: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY, DONG-A ST CO., LTD.
    Inventors: Youngmi Kim, Myung Sook Oh, Seon-Pyo Hong, Mi Won Sohn, Jin Seok Jeong, Hai Hua Jiang, Eunjin Kim, Ja Young Ryu, Young Woong Cho, Xiao Fei Du, Sang Zin Choi, Jeong Soo Kim, Byoung Moon Kim
  • Patent number: 10660929
    Abstract: Provided is a kampo medicine for treating multimorbidity of Alzheimer-type dementia or mild cognitive impairment and at least one disease from the group consisting of overactive bladder, constipation, and chronic kidney disease with one drug. A kampo medicine for treating multimorbidity with one drug, comprising a drug combination of orengedokuto and ryokeijutsukanto as an active ingredient, wherein the kampo medicine improves a cognitive function in Alzheimer-type dementia or mild cognitive impairment and relieves and treats at least one disease from overactive bladder, constipation, and chronic kidney disease complicated by Alzheimer-type dementia or mild cognitive impairment at a high rate with one drug.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: May 26, 2020
    Inventor: Yoshiteru Shimoide
  • Patent number: 10632134
    Abstract: Provided are certain methods useful in the treatment of cancer comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor;
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: April 28, 2020
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Jayant Thatte, Anthony C. Blackburn, Sangdon Han, Robert M. Jones, Jae-Kyu Jung, Antonio Garrido Montalban, Biman B. Pal, Jaimie Karyn Rueter, Sonja Strah-Pleynet, Lars Thoresen, Yifeng Xiong, Dawei Yue, Xiuwen Zhu
  • Patent number: 10617733
    Abstract: The present invention relates to a pharmaceutical composition comprising non-decarboxylated ?9 Tetrahydrocannabinol (THC), Cannabidiol (CBD), and at least one small molecule selected from Citric Acid, Ascorbic Acid, Citrus Essential Oil(s), Lecithin, one or more sugar(s), Resveratrol, and combinations thereof, wherein the composition exhibits enhanced therapeutic potency of THC and/or CBD. The present invention is further directed to methods of treating one or more disease(s) or disorder(s) modulated by the activation of the Cannabinoid CB1 and/or CB2 receptors, by administering a therapeutically effective amount of the composition of the present invention to a subject in need thereof.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: April 14, 2020
    Assignee: Rise Life Sciences Corp.
    Inventor: Brooks John Kelly
  • Patent number: 10493126
    Abstract: The invention generally relates to an immunomodulatory protein and a chemotherapeutic agent for simultaneous, contemporaneous or sequential use in the treatment of diseases, more particularly of proliferative diseases, still more particularly of cancer(s), to a combination of an FIP and a chemotherapeutic agent, as well as to the medical and biotechnological applications thereof, more particularly in the field of the treatment of diseases, more particularly of proliferative diseases, still more particularly of cancer(s).
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: December 3, 2019
    Assignee: YEASTERN BIOTECH CO., LTD.
    Inventors: Jiunn-Liang Ko, Ting-Yi Hou, Ming-Fang Wu, Tzu-Chih Chen
  • Patent number: 10493123
    Abstract: Disclosed are methods for treating, preventing and alleviating obesity, fatty liver syndrome, diabetes, one or more metabolic syndrome conditions or complications and/or cancer comprising administering an effective amount of ostreolysin, its functionally related variant, or an extract or mushroom extract comprising the same to subjects in need thereof.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: December 3, 2019
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF of The Hebrew University of Jerusalem LTD.
    Inventors: Betty Schwartz, Einav Yehuda-Shnaidman, Lili Nimri
  • Patent number: 10485997
    Abstract: A system and method may allow a person to rotate a skin care product based on the current climate to help skin transition to and react to changes in temperature and humidity the air. For example, each moisturizer may be formulated to support skin needs for a specific climate, such as tropical climate (i.e., humid and hot air), a desert climate (i.e., dry and hot air), a temperate climate (i.e., normal and mild air), and/or a polar climate (i.e., cold and dry air).
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: November 26, 2019
    Assignee: Pour Moi Beauty, LLC
    Inventor: Ulrike Haslacher
  • Patent number: 10426804
    Abstract: A pentosidine production inhibitor including a lactic acid bacterium fermentation product as an active ingredient, which has a stronger action and a high safety as a component having an action of inhibiting production of pentosidine.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: October 1, 2019
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Naoki Izawa, Daisuke Niwa, Toshiro Sone
  • Patent number: 10413556
    Abstract: A method of inducing the production of insulin in the body by an individual smelling a composition of a solution including testosterone, and inducing the production of insulin in the body of the individual. A method of treating diabetes type 2 by an individual having diabetes type 2 smelling a composition of a solution including testosterone, inducing the production of insulin in the body of the individual, and treating diabetes type 2 in the individual.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: September 17, 2019
    Inventor: Moshe Shifrine
  • Patent number: 10357525
    Abstract: Disclosed herein is a novel use of a polysaccharide mixture for the treatment of hyperglycemia and/or disorders related thereto (e.g., diabetes mellitus). The polysaccharide mixture comprises about 30-50% (wt %) of ?(1?3) glucan and ?(1?6) glucan, and has a molecular weight of at least 500,000. The polysaccharide mixture may be administered to a subject suffering from hyperglycemia in a dose of about 1 to 1,000 mg/Kg to ameliorate or alleviate symptoms associated with hyperglycemia.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: July 23, 2019
    Assignee: TRINEO BIOTECHNOLOGY CO. LTD
    Inventors: Cheng-Po Huang, Cheng-Chiu Tsao, Chao-hsuan Chang, Teng-Hai Chen, Li-Ming Huang, Chieh-Hung Lin
  • Patent number: 10342843
    Abstract: Therapeutic compositions for addressing physiological stresses and aging include an immune modulator and one or more adaptogenic nutrients. Some non-limiting examples of immune modulators include as transfer factor, low molecular weight fraction immune modulators and/or other low molecular weight fractions of colostrum, egg or any other source of transfer factor or low molecular weight fraction immune modulators. Methods for administering immune modulators and adaptogenic nutrients to a subject to address the effects of physiological stresses and aging in the body of the subject, such as inflammatory responses, are also disclosed.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: July 9, 2019
    Assignee: 4Life Patents, LLC
    Inventor: Christopher M. Lockwood
  • Patent number: 10322157
    Abstract: The present invention is directed to a therapeutic method of treatment of diabetes mellitus, particularly diabetes which acquires multiple drug resistance, comprising administering a therapeutically effective amount of Chinese herbal medicine to a subject in need. The Chinese herbal medicine is the decocting extract including the mixture of raw oyster shell powder, raw Os Draconis, Haematitum, Magnetitum, radix Achyranthis Bidentatae, rhizoma Dioscoreae, radix Paeoniae Rubra, radix Rehmanniae, and semen Platycladi.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: June 18, 2019
    Inventor: Chen-Yu Lee
  • Patent number: 10322158
    Abstract: A therapeutic method of treatment of diabetes mellitus, particularly diabetes which acquires insulin resistance, including administering a therapeutically effective amount of Chinese herbal medicine to a subject in need. The Chinese herbal medicine is the decocting extract including the mixture of raw oyster shell powder, raw Os Draconis, Haematitum (Hematite), Magnetitum (Magnetite), radix Achyranthis Bidentatae (Achyranthes bidentata), rhizoma Dioscoreae (Dioscoreae Rhizoma), radix Paeoniae Rubra (Paeoniae Radix Rubra), radix Rehmanniae (Rehmannia), and semen Platycladi (Platycladi Semen).
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: June 18, 2019
    Inventor: Chen-Yu Lee
  • Patent number: 10307470
    Abstract: Immunogenic compositions, cancer vaccines and methods for treating cancer comprising FMS, the fucose-enriched polysaccharide fraction from Reishi F3, are provided. Compositions comprise fucose-enriched Reishi polysaccharide fraction (FMS) MW=˜35 kDa, wherein the FMS is isolated by size-exclusion chromatography from Reishi F3, and the FMS comprises polysaccharides having primarily a backbone selected from 1,4-mannan and 1,6-?-galactan, wherein the backbone is linked to a terminal fucose-containing side-chain Immunogenic compositions comprising glycolipid adjuvants are provided. Antibodies generated by immunogenic compositions disclosed herein bind cancer cells comprising antigens Globo H, Globo H, Gb3, Gb4, Gb5 (SSEA-3) and SSEA-4 on the cell surface.
    Type: Grant
    Filed: July 26, 2014
    Date of Patent: June 4, 2019
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Chung-Yi Wu, Hsien-Yeh Hsu, Shih-Fen Liao, Chi-Hui Liang
  • Patent number: 10293033
    Abstract: The present invention relates to a proteolytic extract obtained from bromelain for the treatment of connective tissue diseases. In particular, the present invention relates to a pharmaceutical composition comprising a proteolytic extract obtained from bromelain for the treatment of diseases such as Dupuytren's disease and Peyronie's disease.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: May 21, 2019
    Assignee: MediWound Ltd.
    Inventors: Lior Rosenberg, Guy Rubin, Eilon Asculai
  • Patent number: 10238702
    Abstract: The pharmaceutical composition is a formulation prepared by the raw materials in parts by weight: 1-300 parts of chlorogenic acid and 1-50 parts of Ganoderma lucidum spore oil, and the preparative process for said pharmaceutical composition was provided. Chlorogenic acid can be used compatibly with Ganoderma lucidum spore oil, with a synergistic effect. Inclusion technique is applied in product development to improve stability of oily liquid material Ganoderma lucidum spore oil and solid material chlorogenic acid obtained from the extract of Eucommia leaves. After inclusion by the inclusion technology, the liquid drugs become powder, and thus easily oxidized natural products could be protected. Moreover, the damage for active ingredients caused by air can be prevented, and the stability and the taste may get improved.
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: March 26, 2019
    Assignee: SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD.
    Inventors: Jie Zhang, Huarong Yang, Chenxu Tian, Lina Zhu, Wang Huang, Yongjiang Yan
  • Patent number: 10226493
    Abstract: The subject invention provides Coriolus versicolor extracts, pharmaceutical compositions comprising the Coriolus versicolor extracts, methods of preparation, and therapeutic uses thereof. Advantageously, the subject Coriolus versicolor extract has immunomodulatory, anti-tumor, anti-microbial, and antiviral effects. In a preferred embodiment, the subject invention can be used to inhibit the metastatic spread of cancer cells. In certain preferred embodiments, the subject invention can be used to treat glioblastoma multiforme, nasopharyngeal carcinoma, breast carcinoma, lung carcinoma, prostate cancer, and colon carcinoma, as well as bacterial, viral, fungal, protozoan, and/or other microbial infection.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: March 12, 2019
    Assignees: BAGI RESEARCH LIMITED, VERSITECH LIMITED
    Inventors: Stanley Chi Chung Chik, Anna Hing-Yee Law, Cindy Lai Hung Yang, Maureen Lau
  • Patent number: 10131488
    Abstract: Described herein is an aerosol hairspray product including a container including a container wall which encloses a reservoir. The reservoir includes from about 40% to about 70% of a hairstyling formulation and from about 30% to about 60% of a dimethyl ether propellant. The hairstyling formulation includes water, one or more hairstyling polymers, and from about 0.05% to about 2% alcohol. A spraying device is attached to the container. The spraying devices includes a valve including a valve housing including a vapor tap including a vapor tap area. A dip tube is connected to the valve. The dip tube includes a dip tube orifice including a dip tube orifice area. The ratio of the vapor tap area to the dip tube orifice area is from about 0.005 to about 0.15.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: November 20, 2018
    Assignee: The Procter and Gamble Company
    Inventors: Jodi Lee Brown, William Mercer Benson, Jose Antonio Carballada
  • Patent number: 10131716
    Abstract: The present invention provides a method for manufacturing fungal pharmaceutical composition, used for extracting a glycosaminoglycan fiber from a fungal cell wall. Differing from the glycosaminoglycan fiber produced by using a fabrication method proposed by Taiwan patent No. 442496 showing many drawbacks including low extraction percentage, coarse fiber, and having light-yellow color, the glycosaminoglycan fiber manufactured by using this novel method reveals the advantages of high extraction percentage, fine fibers, and showing white color. So that, the novel glycosaminoglycan fiber produced by using the present invention's method is suitable for being processed to an excipient.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: November 20, 2018
    Assignees: Taiwan Indigena Botanica Co., Ltd., Taipei Medical University
    Inventors: Cheng-Jeng Tai, Yeu-Ching Shi, Fang-Mo Chang, Ching-Hua Su
  • Patent number: 9872494
    Abstract: The present invention relates to novel active ingredient combinations which consist of fluopyram and other known active ingredients and are very well suited for the control of animal pests, such as insects and/or unwanted acarids and/or nematodes, in foliar and soil application and/or in the treatment of seeds, and are also suitable for increasing yields.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: January 23, 2018
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Heike Hungenberg, Heiko Rieck, Robert Masters
  • Patent number: 9820443
    Abstract: Disclosed herein is an industrial scale process of cultivating cultivating Ganoderma lucidum mycelia. As high as 15 Kg dried Ganoderma lucidum mycelia may be produced from about 300 liters liquid culture every 30 days, and the resulting dried Ganoderma lucidum mycelia are rich in triterpenoids that include at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS).
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: November 21, 2017
    Assignee: DOUBLE CRANE BIOTECHNOLOGY CO. LTD.
    Inventors: Li-Ming Huang, Chih-Wei Chen, Mon-Tarng Chen, Yen-Chun Liu, Kuang-Dee Chen
  • Patent number: 9795810
    Abstract: The present invention relates to a stick type composition comprising propylene glycol, glycerin and water.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: October 24, 2017
    Assignee: COLGATE-PALMOLIVE COMPANY
    Inventors: Christopher T. Chappell, Stefan Gafner, Anne Gale, Nick Holerca, Jennifer L. Lafrance, Steve Misner
  • Patent number: 9788567
    Abstract: To provide a production technique for an edible egg that contains a sufficient amount of ergothioneine by using the biological accumulation of the ergothioneine in eggs, and that has antioxidative activity. This ergothioneine-containing egg is obtained from a hen raised by being fed a hen feed for a prescribed time period, the hen feed being manufactured by manufacturing the ergothioneine-containing extract solution from a waste medium used in the production of edible mushrooms and mixing a prescribed amount of the extract solution into a feed for the hen used generally.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: October 17, 2017
    Assignees: ORIGIN BIOTECHNOLOGY KABUSHIKIKAISHA, KABUSHIKIKAISHA HOKKEN
    Inventors: Kazunari Abe, Toshiaki Ohshima, Rikuo Fukui
  • Patent number: 9717769
    Abstract: The present invention relates to a method for protecting a kidney, which comprises administering an extracellular polysaccharide produced by Ceriporia lacerata; a mycelial culture medium of Ceriporia lacerata containing the extracellular polysaccharide; dried powders of the mycelial culture medium; or an extract of the mycelial culture medium, in an effective amount, to a subject in need of protecting a kidney. The method is effective in protecting a kidney from renal toxicity caused by an anti-cancer agent.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: August 1, 2017
    Assignee: FUGENBIOPHARMA CO., LTD.
    Inventors: Yoon Soo Kim, Hye Dong Yoo, Eun Ji Shin
  • Patent number: 9623053
    Abstract: The present invention belongs to a pharmaceutical composition preparation field of traditional Chinese medicine, and more particularly relates to a pharmaceutical composition for treating AIDS and preparation method thereof. The pharmaceutical composition of the present invention for treating AIDS comprises the following raw medicinal materials: Cordyceps Sinensis in an amount of 3-6 parts by weight, Dried Radix Rehmanniae in an amount of 4-12 parts by weight, Mylabris in an amount of 1-3 parts by weight, and Rhizoma Anemarrhenae in an amount of 3-6 parts by weight. The clinical trials show that the pharmaceutical composition has a relatively good therapeutic effect for treating AIDS.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: April 18, 2017
    Inventor: Zhonglin Wang
  • Patent number: 9592183
    Abstract: An inhibitor of endothelin action or a skin-whitening agent, comprising a compound represented by Formula (1) or a salt thereof as an active ingredient: wherein in Formula (1), R1 represents a formyl group or an alkyl group having 1 to 4 carbon atom(s), and R2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atom(s).
    Type: Grant
    Filed: November 24, 2011
    Date of Patent: March 14, 2017
    Assignee: Kao Corporation
    Inventors: Tsuyoshi Ohba, Daiki Murase, Mitsuru Sugiyama
  • Patent number: 9585927
    Abstract: The invention provides a composition comprising a mixture of extracts obtained from Atractylodes macrocephala, Astragalus membranaceus, Taraxacum mongolicum, Poria cocos, Ligusticum chuanxiong, Ligustrum lucidum, Codonopsis pilosula, Glycyrrhiza uralensis, Hedyotis diffusa, Pseudostellaria heterophylla, and Viola philippica. The present invention further provides a method for treating metastatic breast cancer in a subject in need thereof, comprising: administering to said subject an pharmaceutically effective amount of the composition.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: March 7, 2017
    Assignee: MERIYANA BIO MANAGEMENT B.V.
    Inventor: Chih Hui Lin
  • Patent number: 9572847
    Abstract: The invention discloses an herbal extract of treating lung tumor. The herbal extract comprises Antrodia cinnamomea and Cordyceps militaris, and the herbal extract is manufactured as following: mingling Antrodia cinnamomea and Cordyceps militaris with a weight ratio being between 1:5 and 5:1 to obtain a mixture; blending the mixture with a solvent with a weight-volume percentage being 50%, followed by extracting at 40-90° C. to obtain a herbal solution; and concentrating the herbal solution to obtain the herbal extract.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: February 21, 2017
    Assignee: Kingland Property Corporation, Ltd.
    Inventors: Wei-Cheng Chen, Mei-Chou Lai, Shorong-Shii Liou, I-Min Liu
  • Patent number: 9498508
    Abstract: A pharmaceutical composition for treating cancers and preparation method thereof. Said composition for treating cancers contains Chinese medicinal materials including Rhizoma Pinelliae, Rhizoma Arisaematis, Rhizoma Gastrodiae etc., and said preparation method is in accordance with a conventional Chinese medicinal preparation method, manufacturing said composition to form any one of the ordinary oral preparations.
    Type: Grant
    Filed: September 6, 2015
    Date of Patent: November 22, 2016
    Inventor: Mingchun Xiao
  • Patent number: 9399050
    Abstract: The present invention utilizes the pre-sporulation (preconidial) mycelial stage of entomopathogenic fungi and extracts of the preconidial mycelium as insect and arthropod attractants and/or pathogens. The preconidial preparations can be employed to limit the zoonotic and plant diseases they transmit. The fungus can be cultivated on grain, wood, agricultural wastes or other cellulosic material and extracts can be made thereof. More than one fungus and substrate can be used in combination with one or more antimicrobial, antiprotozoal, antiviral, or genetically modified agents that result in reduced spread of contagions and lessens the damage they inflict on animals and plants.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: July 26, 2016
    Inventor: Paul Edward Stamets
  • Patent number: 9365481
    Abstract: Provided herein are processes of preparing cyclohexenone compounds useful for cancer treatments and/or diseases.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: June 14, 2016
    Assignee: Golden Biotechnology Corporation
    Inventors: Sheng-Yung Liu, Wu-Che Wen, Chih-Ming Chen, Hsiu-Yi Cheng
  • Patent number: 9272010
    Abstract: The invention discloses an herbal extract of treating liver cancer, wherein a method of producing the herbal extract comprising the steps of: blending Antrodia cinnamomea, Rhinacanthus nasutus and Phellinus linteus and obtaining a mixture, wherein the weight percentages of Antrodia cinnamomea, Rhinacanthus nasutus and Phellinus linteus are 33.4 to 60%, 20 to 33.4% and 20 to 33.4% by weight of the mixture, respectively; soaking the mixture with a 95% ethanol solution with a weight-volume percentage being 50%, followed by extracting at 50 to 80° C.; and concentrating the extracted product to obtain the herbal extract. The invention also discloses a method of treating liver cancer.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: March 1, 2016
    Assignee: KINGLAND REAL ESTATE CO., LTD.
    Inventors: Wei-Cheng Chen, Mei-Chou Lai, Shorong-Shii Liou, I-Min Liu
  • Patent number: 9185849
    Abstract: A solid medium of Antrodia cinnamomea comprises 20 to 50 wt % soybean; 30 to 50 wt % coixseed; and 20 to 50 wt % sorghum. A culturing method of Antrodia cinnamomea, comprises providing a solid medium comprising soybean, coixseed and sorghum; preparing a solution of Antrodia cinnamomea, inoculating the solution of Antrodia cinnamomea on the solid medium in a concentration of 1×103 to 1×106 cfu on per 100 g of solid medium, and statically culturing the solution of Antrodia cinnamomea on the solid medium till obtaining hyphae adhered on the solid medium; and culturing the solution of Antrodia cinnamomea by intermittent shaking in a frequency of every 5 to 7 days shaking 5 to 10 minutes, with a period of the culturing by intermittent shaking being more than 40 days.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: November 17, 2015
    Inventors: Po-Lun Wang, Jung-Chi Hsieh, Ting-Yuan Lai, Jui-Lung Cheng
  • Patent number: 9179693
    Abstract: A method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving dietary phosphorus absorption and retention, or for improving the efficacy of the phytase, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (FCR) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g. improving) the immune response of the subject or for reducing populations of pathogenic bacteria in the gastrointestinal tract of a subject, or for reducing nutrient excretion in manure, which method comprising administering to a subject at least one direct fed microbial in combination with a phytase, wherein the phytase is administered to the subject at a dosage of more than about 1500 FTU/kg feed.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: November 10, 2015
    Assignee: DuPont Nutrition Biosciences ApS
    Inventors: Luis Romero, Peter Plumstead, Luke Barnard
  • Patent number: 9161959
    Abstract: Use of a vegetable drug composition in the manufacturing of a pharmaceutical preparation for the treatment of portal hypertension caused by hepatocirrhosis, said preparation comprises 25-38% of extract of radix Salviae Miltiorrhizae, 20-25% of extract of herb Gynostemmae Pentaphylli, 1-6% of alcoholic extract of fructus Schisandrae Chinensis, 19-26% of extract of Cordyceps, 6-8% of extract of pollen Pini, 6-10% of extract of semen Persicae. Said preparation can improve hepatic cell degeneration, necrosis, intraheptic hemorrhage, fiber proliferation, and reduce pressure of portal vein in mammal. A preparation method of said preparation is disclosed.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: October 20, 2015
    Assignee: SHANGHAI SUNDISE CHINESE MEDICINE TECHNOLOGY DEVELOPMENT CO., LTD
    Inventors: Lieming Xu, Cheng Liu, Ping Liu
  • Patent number: 9144542
    Abstract: A composition for promoting hair growth in humans can include at least three of the following ingredients: Pygeum Africanum, Serenoa Repens, Ganoderma Lucidum, Piper Methysticum, and Zinc. The amount by weight of the identified ingredients in a particular formulation may range from at least 5% to no more than 50% of the formulation.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: September 29, 2015
    Assignee: Kay Jay, LLC
    Inventor: Kevin Meehan
  • Patent number: 9138450
    Abstract: The present invention provides methods for treating constipation-predominant irritable bowel syndrome comprising administering to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat constipation-predominant irritable bowel syndrome (c-IBS). Treatment of c-IBS includes the treatment of the constipation component of c-IBS as well as the pain and abdominal discomfort associated with c-IBS. In one embodiment, the polymeric proanthocyanidin compound is crofelemer. The present invention in an alternative embodiment also provides methods for treating alternating constipation-predominant/diarrhea-predominant irritable bowel syndrome.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: September 22, 2015
    Assignee: Napo Pharmaceuticals, Inc.
    Inventors: Barry D. Quart, David P. Rosenbaum
  • Patent number: 9095143
    Abstract: A method for producing an antimicrobial agent, by cutting, or cutting and then milling a plant belonging to the family Juncaceae: mixing the cut plant with a nutrient source for a seed culture of mushroom mycelia, to form a mixture; inoculating the seed culture of mycelia to the mixture of the plant belonging to the family Juncaceae and the nutrient source and then culturing the seed culture at a growth temperature for the seed culture of mycelia to produce the antimicrobial agent.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: August 4, 2015
    Assignee: KABUSHIKI KAISHA OUJU SEIYAKU
    Inventors: Masayoshi Iwahara, Hiroshi Morita, Kazuyuki Miyata
  • Patent number: 9084736
    Abstract: The present invention relates to the use of an extract of Lentinus, as well as the pharmaceutical composition that contains it, within the scope of combating cellulite and subcutaneous accumulations of fat.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: July 21, 2015
    Assignee: Caster
    Inventors: Jean-Christophe Choulot, Patrick Ales
  • Patent number: 9060963
    Abstract: Methods and compositions for reducing and/or inhibiting inflammation by topical application of dermatocosmetic compositions comprising effective amounts of extracts of Coriolus versicolor that have been hydrolyzed by an acid protease, preferably Rhizomucor miehei, and thereafter rendered substantially devoid of acid-protease activity.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: June 23, 2015
    Assignee: Active Organics, Inc.
    Inventors: Michael Bishop, Elysiann Bishop, Walter Smith, Glen Gillis