Extract Or Material Containing Or Obtained From A Multicellular Fungus As Active Ingredient (e.g., Mushroom, Filamentous Fungus, Fungal Spore, Hyphae, Mycelium, Etc.) Patents (Class 424/195.15)
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Publication number: 20140328871Abstract: A method of culturing Antrodia cinnamomea and obtaining Antrodia cinnamomea with improved contents of antcin C and zhankuic acid C is disclosed in the invention. The method comprises: providing a wood segment of Cinnamomum kanehirai; inoculating a strain of Antrodia cinnamomea to the wood segment, to obtain the wood segment inoculated with the strain of Antrodia cinnamomea with 0.162 g dry weight of hyphae and mycelia of the strain of Antrodia cinnamomea per kg wood segment; and irradiating the wood segment inoculated with the strain of Antrodia cinnamomea by a light of wavelength of 600-700 nm to obtain a fruit body; wherein an irradiation time of the wood segment inoculated with the strain of Antrodia cinnamomea is 8-12 hours per day for 30-40 days.Type: ApplicationFiled: May 2, 2013Publication date: November 6, 2014Applicant: DSG TECHNOLOGY, INC.Inventors: Wen-Tin Chu, Yao-Ken Hung, Shorong-Shii Liou, I-Min Liu, Wei-Cheng Chen
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Publication number: 20140328872Abstract: A formula of suppressing viability of tumor cells is disclosed. The formula comprises 27.3-50.0 wt % of Taiwanofungus camphorates, 27.3-40.0% of Ganoderma lucidum and 16.7-45.4% of Glycyrrhiza uralesis Fisch.Type: ApplicationFiled: May 2, 2013Publication date: November 6, 2014Applicant: HERBIO BIO TECH CO., LTD.Inventors: Ming-Shan Wang, Shorong-Shii Liou, I-Min Liu, Hung-Hsung Wu
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Publication number: 20140322260Abstract: It is an object of the present invention to provide a malignant tumor treatment agent that causes no serious side effects as seen in medicine and is highly safe even in long-term daily use because it is made of food material(s), while being superior to the capabilities of the conventional malignant tumor treatment agents, and food and drink including the same. A malignant tumor treatment agent comprising, as an active ingredient, a mixture obtained by mixing together MUGI KOJI (koji malt), SHIITAKE mushroom (Lentinula edodes), coix seed, cacao, nutmeg, coffee, gansun (bamboo shoots), parsley, stevia, and mint. The malignant tumor treatment agent of the present invention and the food and drink including the same show significant effects on malignant tumor treatment. Furthermore, because the food materials are used as raw material, the treatment agent and the food and drink cause no serious side effects as seen in radiation therapy and chemotherapy and are highly safe.Type: ApplicationFiled: November 12, 2012Publication date: October 30, 2014Inventor: Michio TANI
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Publication number: 20140322259Abstract: An extracting method of Antrodia cinnamomea, being apt to improve extraction rate of dehydrosulphurenic acid, comprises: soaking a sample of raw Antrodia cinnamomea in a salt solution, with the sample of raw Antrodia cinnamomea absorbing the salt solution, to obtain a soaked Antrodia cinnamomea; and further soaking the soaked Antrodia cinnamomea in an alcohol solvent, and obtaining an extract of Antrodia cinnamomea through sonication.Type: ApplicationFiled: April 26, 2013Publication date: October 30, 2014Applicant: KANG LI BIOTECH CO., LTD.Inventors: Shih-Chiang Lee, Shorong-Shii Liou, I-Min Liu, Ren-Jye Wang, Hsiu-Tz Pan
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Patent number: 8871197Abstract: A new and distinct variety of higher Basidiomycetes mushroom Cyathus striatus HAI-1302, and extracts thereof are provided. These extracts as well as pharmaceutical composition comprising them are capable of inhibiting growth of cancer cells, arresting cancer cell cycle, reducing DNA synthesis in cancer cells and inducing apoptosis in cancer cells, and are thus useful for the treatment of cancer.Type: GrantFiled: June 2, 2011Date of Patent: October 28, 2014Assignee: Carmel-Haifa University Economic Corporation Ltd.Inventors: Fuad Fares, Lital Shavit, Solomon P. Wasser
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Patent number: 8865181Abstract: An extracting method of Antrodia cinnamomea, being apt to improve extraction rate of dehydrosulphurenic acid, comprises: soaking a sample of raw Antrodia cinnamomea in a salt solution, with the sample of raw Antrodia cinnamomea absorbing the salt solution, to obtain a soaked Antrodia cinnamomea; and further soaking the soaked Antrodia cinnamomea in an alcohol solvent, and obtaining an extract of Antrodia cinnamomea through sonication.Type: GrantFiled: April 26, 2013Date of Patent: October 21, 2014Assignee: Kang Li Biotech Co., Ltd.Inventors: Shih-Chiang Lee, Shorong-Shii Liou, I-Min Liu, Ren-Jye Wang, Hsiu-Tz Pan
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Patent number: 8858954Abstract: The present invention provides a pharmaceutical composition for preventing and treating liver fibrosis or nonalcoholic fatty liver disease, comprising 50 to 90% by weight of Cordyceps sinensis mycelium powder, and 10 to 50% by weight of condensed astragalus powder.Type: GrantFiled: January 9, 2014Date of Patent: October 14, 2014Assignee: TCM Biotech International Corp.Inventors: Huan Ching Hsu, Ya Chun Wang
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Patent number: 8858953Abstract: An herbal composition and a method for treating cancer, especially for lung cancer, useful for enhancing the quality of life.Type: GrantFiled: May 8, 2012Date of Patent: October 14, 2014Inventor: Yu-Hwa Peter Sheng
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Publication number: 20140302086Abstract: The present invention relates to a pharmaceutical composition comprising non-decarboxylated ?9 Tetrahydrocannabinol (THC), Cannabidiol (CBD), and at least one small molecule selected from Citric Acid, Ascorbic Acid, Citrus Essential Oil(s), Lecithin, one or more sugar(s), Resvertrol, and combinations thereof, wherein the composition exhibits an increased but negated psychoactivity with concurrent enhancement in therapeutic potency of THC and/or CBD. The present invention is further directed to methods of treating one or more disease(s) or disorder(s) modulated by the activation of the Cannabinoid CB1 and/or CB2 receptors, by administering a therapeutically effective amount of the composition of the present invention to a subject in need thereof.Type: ApplicationFiled: January 1, 2014Publication date: October 9, 2014Applicant: BROOKS KELLY RESEARCH, LLCInventor: Brooks J. Kelly
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Publication number: 20140286989Abstract: Disclosed is a compound isolated from Antrodia camphorata, represented by formula I: wherein R1 is a hydrogen atom or an acetyl group; and a method of inhibiting cancer cell growth by using the compound, the cancer is selected from the group consisting of lung cancer, colon cancer, prostate cancer, liver cancer and breast cancer.Type: ApplicationFiled: August 6, 2013Publication date: September 25, 2014Inventor: Hui Ling Tseng
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Publication number: 20140271704Abstract: Methods are described for producing reduced, methylated, biologically active forms of folate, including 5-methyltetrahydrofolate (i.e. 5-methyltetrahydropteroylglutamic acid), 5-formyltetrahydrofolate, 10-formyltetrahydrofolate and tetrahydrofolate. Edible mushroom-producing fungi are cultivated to enhance the uptake of pteroylmonoglutamate (synthetic folate) into edible portions of the plants. The mushroom-producing fungi reduce and methylate the pteroylmonoglutamates into activated folates. The cultivated mycelia or mushrooms of the mushroom-producing fungi are harvested, and may be consumed directly or processed into oral dosage formats (capsules, tablets, softgels, powders, gel packets, liquids, nutritional bars, beverages) for use as functional foods or nutritional supplements.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: JARROW FORMULAS, INC.Inventors: Peilin Guo, Jarrow L. Rogovin
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Publication number: 20140271703Abstract: The present invention provides a therapeutic agent for dementia comprising a pharmaceutically active substance derived from Hericium ramosum.Type: ApplicationFiled: March 13, 2013Publication date: September 18, 2014Applicant: KIBUN FOODS INC.Inventors: Kohei SURUGA, Yasuhiro KOMATSU, Kazunari KADOKURA, Yoshihiro SEKINO, Kenichi MISHIMA, Michihiro FUJIWARA
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Patent number: 8821888Abstract: A novel ascomycetous Xylogone ganodermophthora strain has antifungal activity. A composition includes the strain as an active ingredient for preventing plant diseases. The strain suppresses the growth of pathogenic fungi, including Phytophthora capsici, in plants. Therefore, the composition containing the strain, or a culture or extract thereof, as an active ingredient for preventing plant diseases has excellent antifungal activity and can thus be used as an environmentally friendly and pollution-free pesticide.Type: GrantFiled: October 24, 2013Date of Patent: September 2, 2014Assignee: The Director of Chungcheongbuk-Do Agricultutal Research and Extension ServicesInventors: Hyo Jung Kang, Ki Su Ahn, Chong Woo Han, Kyung Heon Jeong, See Jung Park, In Gyu Song, Tae Yun, Kyeong Beom Min
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Publication number: 20140234366Abstract: The invention aims to provide a composition for treating atopic dermatitis, bronchial asthma, allergic rhinitis or major depressive disorder (depression), comprising a mixture of Formula antidoti coptidis (orengedokuto) and Formula repletionis animalis et supletionis medii (hochuekkito) or a mixture of Formula antidoti coptidis (orengedokuto) and Formula glycyrrhizae atractylodis cinnamomi hoelen (ryokeijutsukanto) as active components. Provided is a composition for preventing or treating an allergic disease or major depressive disorder, comprising a mixture of Formula antidoti coptidis (orengedokuto) and Formula repletionis animalis et supletionis medii (hochuekkito) or a mixture of Formula antidoti coptidis (orengedokuto) and Formula glycyrrhizae atractylodis cinnamomi hoelen (ryokeijutsukanto) as active components.Type: ApplicationFiled: February 21, 2013Publication date: August 21, 2014Inventor: Yoshiteru Shimoide
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Patent number: 8809578Abstract: The present invention relates to a novel compound having excellent antioxidant activity, isolated from Ramalina terebrata, and more particularly to a novel compound, RAMALIN™, having excellent antioxidant activity, isolated from the Antarctic lichen Ramalina terebrata, a method for preparing the RAMALIN™, and a pharmaceutical composition, a functional food and a functional cosmetic composition, which contain the RAMALIN™ as an active ingredient. The RAMALIN™ according to the invention has significantly excellent antioxidant effects compared to commercially available antioxidants, and thus can be widely used in agents for treating oxidation-related diseases, anti-aging functional foods, functional cosmetic products for skin whitening and wrinkle reduction, etc.Type: GrantFiled: November 10, 2009Date of Patent: August 19, 2014Assignee: Korea Ocean Research and Development InstituteInventors: Joung Han Yim, Hong Kum Lee, Hari Datta Bhattarai, Paudel Babita, Il Chan Kim, Soon Gyu Hong, Doc Kyu Kim, Yoo Kyung Lee, Sung Gu Lee, Hyun Cheol Oh
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Publication number: 20140220150Abstract: The present invention is based on a plurality of benefits from the extracts of mycelia of individual fungal species, and their mixtures, to provide an armamentarium of defenses from multiple stressors in order to help bees survive and more particularly overcome a complex of symptoms collectively called colony collapse disorder (CCD). The methods and compositions of this designed fungal bioshield helps tilt the balance in favor of bee colony survival, improving the health conditions, disease resistance, pesticide tolerance, pollution tolerance, drought tolerance, pollination abilities, and quality of the honey produced by bees.Type: ApplicationFiled: April 7, 2014Publication date: August 7, 2014Inventor: Paul Edward Stamets
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Publication number: 20140205626Abstract: Disclosed herein are fermented coffee beans prepared by inoculating and culturing mycelium of fungus into coffee beans. The fermented coffee beans according to the present invention may have immune-boosting and anti-inflammatory activities.Type: ApplicationFiled: June 7, 2013Publication date: July 24, 2014Inventors: Byung-Choong CHOI, Dong-Goo KIM, Chun-Kyu PARK, Ji-Young SHIN, Hoon KIM, Mi-Ra LEE, Hee-Yeon LEE, Kwang-Won YU
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Publication number: 20140205550Abstract: A method of cosmetic care comprising activating capsase-14 expression in skin deficient in caspase-14 expression by applying, on at least one skin zone in need thereof, an effective amount of a plant extract selected from the group consisting of litchi, glasswort, peach, soja seed, sweet basil, cucumber, chanterelle, leek, kiwi fruit, rhubarb, grapefruit, wheat, raspberry, plum, and mixtures thereof, to activate caspase-14 expression in said skin.Type: ApplicationFiled: January 23, 2013Publication date: July 24, 2014Inventors: Hugo A. Corstjens, Lieve Declercq, Gerry Eyckmans, Luc F.J. Van Overloop
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Patent number: 8784835Abstract: A method for producing muscimol and or/reducing ibotenic acid from Amanita tissue, and or producing a nutritional supplement therefrom.Type: GrantFiled: July 2, 2013Date of Patent: July 22, 2014Inventor: Trent Austin
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Patent number: 8784912Abstract: The invention provides a method for forming a fermented composition of mung bean hulls, including: mixing mung bean hulls and water to form a mixture; adding a fungus into the mixture, wherein the fungus includes Rhizopus spp. or Aspergillus spp.; and fermenting the mixture to form a fermented composition. The invention also includes a fermented composition of mung bean hulls by the method and an anti-oxidation and anti-inflammation composition containing the fermented composition of mung bean hulls.Type: GrantFiled: October 19, 2009Date of Patent: July 22, 2014Assignee: Food Industry Research & Development InstituteInventors: Shu-Chen Huang, Hing-Yuen Chan, Chiao-Ming Liao, Li-Chuan Liao, Shiaw-Min Hwang
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Publication number: 20140199341Abstract: The present invention relates to the use of antrodia camphorata in the treatment of skin conditions, such as acne vulgaris, urticaria and eczema, allergic rhinitis, diabetes mellitus and its complications, cancer cachexia, hypercholesterolemia, gout in a subject in need of such treatment. The present invention is also directed to the use of antrodia camphorata in the prevention and treatment of oral cancer and arterial restenosis, in a subject in need of such prevention. The methods comprise the steps of: identifying a subject in need thereof, and administering to the subject a formulation comprising an effective amount of antrodia camphorata, whereby the symptoms in the subject are reduced or prevented. The composition can be a pharmaceutical composition or a nutraceutical composition.Type: ApplicationFiled: March 17, 2014Publication date: July 17, 2014Inventor: Chieh-Chou YU
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Publication number: 20140193454Abstract: A method for preparing a Ceriporia lacerata mycelium culture extract and a pharmaceutical composition for preventing or treating diabetes and diabetic complications, contains a Ceriporia lacerata mycelium culture extract prepared by the above method. The Ceriporia lacerata mycelium culture extract prepared according to the preparation method of the invention has a higher content of exopolysaccharide than the extract prepared by the method described in the prior art document of the present inventors, and thus it can be used as the active material of pharmaceutical compositions and functional foods against diabetic diseases.Type: ApplicationFiled: January 9, 2013Publication date: July 10, 2014Inventor: Byoung Cheon KIM
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Publication number: 20140193456Abstract: The invention comprises of an implementation of the lyophilization process in a method for a large-scale preservation of the entire biological material prior to the extraction and/or the utilization/manipulation of any substances of the biological content. The drying-conservation of all the natural substances is achieved via deep-freezing evaporation followed by complete drying of the biological material by the means of sublimation, and other additional manipulations and procedures suitable for the preparation of various commercially viable products further on.Type: ApplicationFiled: January 8, 2014Publication date: July 10, 2014Inventor: Hristem Mitkov Dyanov
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Publication number: 20140193455Abstract: A pharmaceutical composition for preventing or treating steroid-induced diabetes (SID) and a health functional food, and more particularly to a pharmaceutical composition for preventing or treating SID and a health functional food, contain a Ceriporia lacerata culture extract as an active ingredient. The pharmaceutical composition and the health functional composition have the effect of protecting INS-1 insulin-secreting cells by blocking the steroid-mediated proliferation inhibition and apoptosis induction of INS-1 insulin-secreting cells. Thus, the pharmaceutical composition and the health functional composition can be developed as the active ingredient of pharmaceutical or functional food compositions serving to protect or regenerate ?-cells by blocking the steroid-mediated growth inhibition and apoptosis of ?-cells.Type: ApplicationFiled: January 9, 2013Publication date: July 10, 2014Inventor: Byoung Cheon KIM
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Patent number: 8765138Abstract: Compounds having unique antiviral and antibacterial properties are prepared from medicinal mushroom mycelium, extracts and derivatives. The compositions are derived from Fomitopsis, Piptoporus, Ganoderma, Inonotus, Trametes, Pleurotus, and blends of medicinal mushroom species and are useful in preventing and treating viruses including Poxyiridae and Orthopox viruses, flu viruses including bird flu (H5N1), SARS and Hepatitis C (HCV), as well as infections from Mycobacterium tuberculosis, Staphylococcus aureus and Escherichia coli.Type: GrantFiled: September 24, 2008Date of Patent: July 1, 2014Inventor: Paul Edward Stamets
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Patent number: 8758768Abstract: A process is described for the production of an immunostimulant by submerged cultivation of Lentinus edodes in which mycelium from agar plates or a fermentation broth is added to a liquid medium in a shake flask or a bioreactor containing nutrients such as malt extract, yeast extract, peptone and glucose having access to air or to which air is added, and which is kept in constant movement at approx. 28° C. At the proper conditions, there will be an increase in the production of extracellular lentinan, which is shown to be a better immunostimulant than intracellular lentinan. The extracellular product is precipitated from the growth medium by means of methods for the precipitation of microbial polysaccharide.Type: GrantFiled: October 1, 2010Date of Patent: June 24, 2014Assignee: Glycanova ASInventors: Bjoern Kristiansen, David Waddell
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Patent number: 8753656Abstract: The present invention utilizes extracts of the pre-sporulation (preconidial) mycelial stage of entomopathogenic fungi as insect and arthropod attractants and/or pathogens and can be employed to limit the zoonotic diseases they transmit. The fungus can be cultivated on grain, wood, agricultural wastes or other cellulosic material and extracts can be made thereof. More than one fungus and substrate can be used in combination with one or more antimicrobial, antiprotozoal, antiviral, and genetically modified agents that result in reduced spread of contagions and lessens the damage they inflict on animals, and plants.Type: GrantFiled: October 24, 2011Date of Patent: June 17, 2014Inventor: Paul Stamets
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Publication number: 20140154195Abstract: Topical skin care composition comprising an extract of white strawberry and at least one additional skin care active.Type: ApplicationFiled: May 1, 2013Publication date: June 5, 2014Inventors: Fatemeh Mohammadi, Nadine A. Pernodet, Donald F. Collins
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Publication number: 20140147464Abstract: A method for inducing autophagy in a subject having an autophagy defect is provided. The method of the present invention includes the step of administering to the subject a therapeutically effective amount of a Ganoderma lucidum extract, wherein the autophagy enhances clearance of protein aggregates in the subject.Type: ApplicationFiled: November 26, 2012Publication date: May 29, 2014Applicant: NATIONAL YANG-MING UNIVERSITYInventors: Rong-Tsun Wu, Lin-Yea Horng, Hui-Ching Sung, Li-Wen Chen
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Patent number: 8734863Abstract: The invention relates to a bioactive fraction of Petiveria alliacea having an antitumour activity, and to the use of same for producing medicaments for treating cancer. The invention also relates to a pharmaceutical combination for treating, comprising the bioactive fraction of Petiveria alliacea and at least one immunostimulant that can produce the phenotypic and/or functional maturation of the dendritic cells. The invention further relates to sequential administration of the bioactive fraction of Petiveria alliacea or the composition containing same and immunostimulant agent.Type: GrantFiled: September 22, 2010Date of Patent: May 27, 2014Assignee: Pontificia Universidad JaverianaInventors: Susana Fiorentino Gomez, María Claudia Cifuentes Barreto, John Freddy Hernandez Montaño, Sandra Paola Santander Gonzales, Claudia Patricia Urueña Pinzon, Diana Mercedes Castañeda Uvajoa
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Patent number: 8734672Abstract: The objective to be solved by the present invention is to provide an ice-crystallization inhibitor which has a practicable and excellent ice-crystallization inhibiting property and which can be efficiently and stably produced in a safe process suitable for food production. Also, the objective of the present invention is to provide an antibody which specifically reacts with the ice-crystallization inhibitor, and a composition, a food, a biological sample protectant and a cosmetic which contain the ice-crystallization inhibitor. Furthermore, the objective of the present invention is to provide a polysaccharide which is derived from a basidiomycete and which is used for inhibiting ice-crystallization of a liquid containing water, and a method for inhibiting ice-crystallization of a liquid containing water. The ice-crystallization inhibitor according to the present invention is characterized in being a polysaccharide derived from a basidiomycete.Type: GrantFiled: August 11, 2011Date of Patent: May 27, 2014Assignee: Kaneka CorporationInventors: Hidehisa Kawahara, Yoshihide Koide, Naoki Arai, Jun Tomono
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Patent number: 8728462Abstract: Antimicrobial compositions comprising one or more compound components generally recognized as safe for human consumption, and related methods of use, such compositions and methods as can be employed in a wide range of agricultural, industrial, building, pharmaceutical and/or personal care products and applications.Type: GrantFiled: April 27, 2010Date of Patent: May 20, 2014Assignee: Jeneil Biosurfactant Company, LLCInventors: Niranjan Ramanlal Gandhi, Victoria Palmer Skebba, Gary A. Strobel
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Patent number: 8722056Abstract: The present invention relates to novel and non-obvious methods and media for preparing fermentation products of Cordyceps sinensis. The present invention also relates to novel and non-obvious compositions comprising fermentation products of Cordyceps sinensis produced by the methods of the invention or obtained from other sources. The present invention also relates to novel and non-obvious methods of treating patients by administering the compositions of the invention. In one embodiment, the Cordyceps sinensis mycelia is Paecilomyces hepiali mycelia. In another embodiment the compositions of the invention are used to treat patients infected with hepatitis C.Type: GrantFiled: August 6, 2009Date of Patent: May 13, 2014Assignee: TCM Biotech International Corp.Inventors: Ya-Chun Wang, Wang-Sheng Ko, Chih-Cheng Chang
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Publication number: 20140127256Abstract: The present invention provides a pharmaceutical composition for preventing and treating liver fibrosis or nonalcoholic fatty liver disease, comprising 50 to 90% by weight of Cordyceps sinensis mycelium powder, and 10 to 50% by weight of condensed astragalus powder.Type: ApplicationFiled: January 9, 2014Publication date: May 8, 2014Inventors: Huan Ching Hsu, Ya Chun Wang
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Publication number: 20140120130Abstract: An extraction technology of a Xiao-yao-drink includes a medicine preparing step of preparing herbal medicines, a pulverizing step of pulverizing the herbal medicines to produce medicinal solid particles, a liquid extracting step of adding the medicinal solid particles into an extraction liquid to dissolve the medicinal solid particles in the extraction liquid, an ultrasonic extraction step of impacting the medicinal solid particles in the extraction liquid by concentrated ultrasonic waves to crush the medicinal solid particles into medicinal molecules, and a centrifugal filtering step of filtering the medicinal molecules from the extraction liquid by a strainer cloth to produce a medicinal extract which constructs a Xiao-yao-drink product. Thus, the extraction technology uses an ultrasonic extraction procedure to crush the medicinal solid particles into medicinal molecules by concentrated ultrasonic waves to efficiently increase the active component of the herbal medicine.Type: ApplicationFiled: December 26, 2012Publication date: May 1, 2014Applicants: MESOPHASE TECHNOLOGIES, INCInventors: Jiunn-Jye Chuu, Mei-Wen Kao
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Patent number: 8709399Abstract: The present invention relates to a new method for pest control and/or for preventing or treating pest infestation. Said method comprises the inoculation of plants, parts of plants or the surrounding of said plants with an effective amount of endophytic Beauveria bassiana strains. In a further aspect the present invention relates to the use of an isolated Beauveria bassiana strain having superior properties. Furthermore, biopesticides and compositions for pest control, in particular, for control of herbivorous insects and/or plant pathogens, are provided.Type: GrantFiled: March 24, 2011Date of Patent: April 29, 2014Assignee: Georg-August-Universität Göttingen Stiftung Öffentlichen RechtsInventors: Stefan Vidal, Tadele Tefera
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Publication number: 20140105928Abstract: Compounds having unique antiviral and antibacterial properties are prepared from medicinal mushroom mycelium, extracts and derivatives. The compositions are derived from Fomitopsis, Piptoporus, Ganoderma, Inonotus, Trametes, Pleurotus, and blends of medicinal mushroom species and are useful in preventing and treating viruses including Poxyiridae and Orthopox viruses, flu viruses including bird flu (H5N1), SARS and Hepatitis C(HCV), as well as infections from Mycobacterium tuberculosis, Staphylococcus aureus and Escherichia coli.Type: ApplicationFiled: December 20, 2013Publication date: April 17, 2014Inventor: Paul Edward Stamets
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Patent number: 8697049Abstract: Provided is a modified bacteriophage capable of infecting a target bacterium, which bacteriophage includes an ?/? small acid-soluble spore protein (SASP) gene encoding a SASP which is toxic to the target bacterium, wherein the SASP gene is under the control of a constitutive promoter which is foreign to the bacteriophage and the SASP gene.Type: GrantFiled: August 6, 2008Date of Patent: April 15, 2014Assignee: Phico Therapeutics Ltd.Inventors: Heather Fairhead, Adam Wilkinson, Sarah Holme, Katy Pitts, Alison Jackson
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Patent number: 8697086Abstract: The present invention relates to the use of antrodia camphorata in the treatment of skin conditions, allergic rhinitis, diabetes mellitus and its complications, cancer cachexia, hypercholesterolemia, gout in a subject in need of such treatment. The present invention is also directed to the use of antrodia camphorata in the prevention and treatment of oral cancer and arterial restenosis, in a subject in need of such prevention. The methods comprise the steps of: identifying a subject in need thereof, and administering to the subject a formulation comprising an effective amount of antrodia camphorata, whereby the symptoms in the subject are reduced or prevented. The composition can be a pharmaceutical composition or a nutraceutical composition.Type: GrantFiled: January 19, 2010Date of Patent: April 15, 2014Inventor: Chieh-Chou Yu
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Patent number: 8697099Abstract: A cosmetic treatment system is provided having ingredients that may prevent signs of aging, improve the aesthetic appearance of skin, and promote recovery from environmental stresses. The composition includes natural ingredients, including at least one ingredient or extract from rosemary; at least one ingredient or extract from Centella, Echinacea, Alpinia or mixtures thereof; a DNA repair enzyme; and at least one pharmaceutically or cosmetically acceptable vehicle. The treatment system may further include a patch for applying the cosmetic ingredients and/or a packaging system for holding the components of the cosmetic treatment system.Type: GrantFiled: July 19, 2010Date of Patent: April 15, 2014Assignee: Access Business Group International LLCInventors: John V. Scimeca, Amy C. Zimmerman, Mark F. Mettler, Akiko Kudo, Yoko Kawasaki
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Publication number: 20140099336Abstract: Provided are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance with Compound A. Also provided are methods of treating at least one phase of substance dependence on at least one substance in patients and certain methods of treating at least one phase of cocaine dependence in patients.Type: ApplicationFiled: December 6, 2013Publication date: April 10, 2014Applicant: Biotie Therapies, Inc.Inventors: Tom Woiwode, Mark Moran, Lesley Pickford
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Publication number: 20140086951Abstract: This invention provides a pharmaceutical composition for modulating immune system comprising at least one polysaccharide extracted from Radix Astragali, Radix Codonopsis, Ganoderma sinense, or mixtures thereof, and their extraction process. The present invention further relates to a method of modulating immune system by applying said pharmaceutical composition to a subject suffering from cancers, and a method of preventing and/or pretreating and/or treating cancers in the subject, where said method comprises applying said pharmaceutical composition before/during chemotherapy.Type: ApplicationFiled: September 23, 2013Publication date: March 27, 2014Applicant: Hong Kong Baptist UniversityInventor: Quanbin HAN
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Patent number: 8679507Abstract: A composition of an olfactory stimulus mechanism for stimulating the production of testosterone. A method of increasing the level of testosterone in an individual by smelling the truffle extract, causing androgens in the truffle extract to attach to the olfactory bulb in the individual, and inducing testosterone production. A method of preventing the onset of Alzheimer's disease in an individual by the individual smelling the truffle extract, and inducing testosterone production in the individual. A method of treating symptoms of menopause in a woman by the woman smelling the truffle extract, and inducing testosterone production in the woman. A method of treating andropause in a man by a man smelling the truffle extract, and inducing testosterone production in the man.Type: GrantFiled: April 17, 2013Date of Patent: March 25, 2014Inventor: Moshe Shifrine
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Publication number: 20140079772Abstract: The present invention discloses anti-cancer compositions, and associated methods, including an anti-cancer composition comprising: a cellular energy inhibitor having the structure according to formula I wherein X is selected from the group consisting of: a nitro, an imidazole, a halide, sulfonate, a carboxylate, an alkoxide, and amine oxide; and R is selected from the group consisting of: OR?, N(R?)2, C(O)R??, C1-C6 alkyl, C6-C12 aryl, C1-C6 heteroalkyl, a C6-C12 heteroaryl, H, and an alkali metal; where R? represents H, alkali metal, C1-C6 alkyl, C6-C12 aryl or C(O)R??, R? represents H, C1-C6 alkyl, or C6-C12 aryl, and R?? represents H, C1-C20 alkyl or C6-C12 aryl. The anti-cancer composition can additionally comprise at least one sugar, which stabilizes the cellular energy inhibitor by substantially preventing the inhibitor from hydrolyzing. Also, the anti-cancer composition can comprise a hexokinase inhibitor.Type: ApplicationFiled: September 16, 2013Publication date: March 20, 2014Inventor: Young Hee Ko
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Patent number: 8672245Abstract: An aqueous formulation comprising edible fungal particles especially consisting substantially of fungal mycelia is described. The ingredient may be combined with other ingredients to produce a wide range of foodstuffs or food ingredients including desserts (e.g. yoghurt), reconstitutable drinks or soup and extruded foodstuffs (e.g. savoury snack foods). Foodstuffs prepared may have medical applications (e.g. for treatment of joint mobility disorders, reducing fat uptake, lowering cholesterol, immune function stimulation, use on a pre-biotic and/or for affecting satiety).Type: GrantFiled: December 21, 2009Date of Patent: March 18, 2014Assignee: Marlow Foods LimitedInventors: Timothy John Andrew Finnigan, Robin Blanchard
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Patent number: 8658181Abstract: The present invention provides a pharmaceutical composition for preventing and treating liver fibrosis or nonalcoholic fatty liver disease, comprising 50 to 90% by weight of Cordyceps sinensis mycelium powder, and 10 to 50% by weight of condensed astragalus powder.Type: GrantFiled: October 31, 2012Date of Patent: February 25, 2014Assignee: TCM Biotech International Corp.Inventors: Huan Ching Hsu, Ya Chun Wang
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Publication number: 20140037577Abstract: The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.Type: ApplicationFiled: October 10, 2013Publication date: February 6, 2014Inventor: Michael A. Zeligs
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Publication number: 20140037674Abstract: Methods and compositions are provided for alleviating and/or preventing one or more side effects associated with exposure to radiation in a subject exposed to radiation or at risk for exposure to radiation comprising oral administration to the subject of an amount of an edible source of melanin effective to alleviate a side effect associated with radiation.Type: ApplicationFiled: March 15, 2012Publication date: February 6, 2014Applicant: Albert Einstein College of Medicine of Yeshiva UniversityInventors: Ekaterina Dadachova, Arturo Casadevall
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Patent number: 8642645Abstract: The present invention relates to a pharmaceutical composition comprising ?9 Tetrahydrocannabinol (THC), Cannabidiol (CBD), and at least one small molecule selected from Citric Acid, Ascorbic Acid, Citrus Essential Oil(s), Lecithin, one or more sugar(s), Resvertrol, and combinations thereof, wherein the composition exhibits an increased but negated psychoactivity with concurrent enhancement in therapeutic potency of THC and/or CBD. The present invention is further directed to methods of treating one or more disease(s) or disorder(s) modulated by the activation of the Cannabinoid CB1 and/or CB2 receptors, by administering a therapeutically effective amount of the composition of the present invention to a subject in need thereof.Type: GrantFiled: January 30, 2012Date of Patent: February 4, 2014Assignee: Brooks Kelly Research, LLC.Inventor: Brooks J. Kelly
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Publication number: 20140030288Abstract: A method of protecting a host grass from stress, such as caused by insect pests, by artificially inoculating the host grass with an endophyte-containing composition is disclosed. The endophyte produces loline at a level sufficient to confer protection to the endophyte-infected host grass and does not produce detectable levels of alkaloids having toxicity to ruminant animals such as sheep, cattle, goats, or deer. In vitro cultures of the endophyte Neotyphodium uncinatum, var. U2 are disclosed as well as infected plants and seeds. The infected plants and seeds produce 5.0-20,000 ?g lolines per gram dry weight of grass and do not produce detectable levels of alkaloids having toxicity to ruminant animals such as ergovaline, peramine, lolitrem B and epoxy-Janthitrems.Type: ApplicationFiled: July 25, 2012Publication date: January 30, 2014Applicant: Cropmark Seeds LtdInventor: Nicholas Evan Cameron