Extract Or Material Containing Or Obtained From A Multicellular Fungus As Active Ingredient (e.g., Mushroom, Filamentous Fungus, Fungal Spore, Hyphae, Mycelium, Etc.) Patents (Class 424/195.15)
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Patent number: 9795810Abstract: The present invention relates to a stick type composition comprising propylene glycol, glycerin and water.Type: GrantFiled: September 30, 2008Date of Patent: October 24, 2017Assignee: COLGATE-PALMOLIVE COMPANYInventors: Christopher T. Chappell, Stefan Gafner, Anne Gale, Nick Holerca, Jennifer L. Lafrance, Steve Misner
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Patent number: 9788567Abstract: To provide a production technique for an edible egg that contains a sufficient amount of ergothioneine by using the biological accumulation of the ergothioneine in eggs, and that has antioxidative activity. This ergothioneine-containing egg is obtained from a hen raised by being fed a hen feed for a prescribed time period, the hen feed being manufactured by manufacturing the ergothioneine-containing extract solution from a waste medium used in the production of edible mushrooms and mixing a prescribed amount of the extract solution into a feed for the hen used generally.Type: GrantFiled: November 20, 2014Date of Patent: October 17, 2017Assignees: ORIGIN BIOTECHNOLOGY KABUSHIKIKAISHA, KABUSHIKIKAISHA HOKKENInventors: Kazunari Abe, Toshiaki Ohshima, Rikuo Fukui
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Patent number: 9717769Abstract: The present invention relates to a method for protecting a kidney, which comprises administering an extracellular polysaccharide produced by Ceriporia lacerata; a mycelial culture medium of Ceriporia lacerata containing the extracellular polysaccharide; dried powders of the mycelial culture medium; or an extract of the mycelial culture medium, in an effective amount, to a subject in need of protecting a kidney. The method is effective in protecting a kidney from renal toxicity caused by an anti-cancer agent.Type: GrantFiled: November 25, 2016Date of Patent: August 1, 2017Assignee: FUGENBIOPHARMA CO., LTD.Inventors: Yoon Soo Kim, Hye Dong Yoo, Eun Ji Shin
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Patent number: 9623053Abstract: The present invention belongs to a pharmaceutical composition preparation field of traditional Chinese medicine, and more particularly relates to a pharmaceutical composition for treating AIDS and preparation method thereof. The pharmaceutical composition of the present invention for treating AIDS comprises the following raw medicinal materials: Cordyceps Sinensis in an amount of 3-6 parts by weight, Dried Radix Rehmanniae in an amount of 4-12 parts by weight, Mylabris in an amount of 1-3 parts by weight, and Rhizoma Anemarrhenae in an amount of 3-6 parts by weight. The clinical trials show that the pharmaceutical composition has a relatively good therapeutic effect for treating AIDS.Type: GrantFiled: December 31, 2013Date of Patent: April 18, 2017Inventor: Zhonglin Wang
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Patent number: 9592183Abstract: An inhibitor of endothelin action or a skin-whitening agent, comprising a compound represented by Formula (1) or a salt thereof as an active ingredient: wherein in Formula (1), R1 represents a formyl group or an alkyl group having 1 to 4 carbon atom(s), and R2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atom(s).Type: GrantFiled: November 24, 2011Date of Patent: March 14, 2017Assignee: Kao CorporationInventors: Tsuyoshi Ohba, Daiki Murase, Mitsuru Sugiyama
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Patent number: 9585927Abstract: The invention provides a composition comprising a mixture of extracts obtained from Atractylodes macrocephala, Astragalus membranaceus, Taraxacum mongolicum, Poria cocos, Ligusticum chuanxiong, Ligustrum lucidum, Codonopsis pilosula, Glycyrrhiza uralensis, Hedyotis diffusa, Pseudostellaria heterophylla, and Viola philippica. The present invention further provides a method for treating metastatic breast cancer in a subject in need thereof, comprising: administering to said subject an pharmaceutically effective amount of the composition.Type: GrantFiled: November 26, 2014Date of Patent: March 7, 2017Assignee: MERIYANA BIO MANAGEMENT B.V.Inventor: Chih Hui Lin
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Patent number: 9572847Abstract: The invention discloses an herbal extract of treating lung tumor. The herbal extract comprises Antrodia cinnamomea and Cordyceps militaris, and the herbal extract is manufactured as following: mingling Antrodia cinnamomea and Cordyceps militaris with a weight ratio being between 1:5 and 5:1 to obtain a mixture; blending the mixture with a solvent with a weight-volume percentage being 50%, followed by extracting at 40-90° C. to obtain a herbal solution; and concentrating the herbal solution to obtain the herbal extract.Type: GrantFiled: December 23, 2013Date of Patent: February 21, 2017Assignee: Kingland Property Corporation, Ltd.Inventors: Wei-Cheng Chen, Mei-Chou Lai, Shorong-Shii Liou, I-Min Liu
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Patent number: 9498508Abstract: A pharmaceutical composition for treating cancers and preparation method thereof. Said composition for treating cancers contains Chinese medicinal materials including Rhizoma Pinelliae, Rhizoma Arisaematis, Rhizoma Gastrodiae etc., and said preparation method is in accordance with a conventional Chinese medicinal preparation method, manufacturing said composition to form any one of the ordinary oral preparations.Type: GrantFiled: September 6, 2015Date of Patent: November 22, 2016Inventor: Mingchun Xiao
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Patent number: 9399050Abstract: The present invention utilizes the pre-sporulation (preconidial) mycelial stage of entomopathogenic fungi and extracts of the preconidial mycelium as insect and arthropod attractants and/or pathogens. The preconidial preparations can be employed to limit the zoonotic and plant diseases they transmit. The fungus can be cultivated on grain, wood, agricultural wastes or other cellulosic material and extracts can be made thereof. More than one fungus and substrate can be used in combination with one or more antimicrobial, antiprotozoal, antiviral, or genetically modified agents that result in reduced spread of contagions and lessens the damage they inflict on animals and plants.Type: GrantFiled: June 20, 2013Date of Patent: July 26, 2016Inventor: Paul Edward Stamets
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Patent number: 9365481Abstract: Provided herein are processes of preparing cyclohexenone compounds useful for cancer treatments and/or diseases.Type: GrantFiled: February 20, 2014Date of Patent: June 14, 2016Assignee: Golden Biotechnology CorporationInventors: Sheng-Yung Liu, Wu-Che Wen, Chih-Ming Chen, Hsiu-Yi Cheng
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Patent number: 9272010Abstract: The invention discloses an herbal extract of treating liver cancer, wherein a method of producing the herbal extract comprising the steps of: blending Antrodia cinnamomea, Rhinacanthus nasutus and Phellinus linteus and obtaining a mixture, wherein the weight percentages of Antrodia cinnamomea, Rhinacanthus nasutus and Phellinus linteus are 33.4 to 60%, 20 to 33.4% and 20 to 33.4% by weight of the mixture, respectively; soaking the mixture with a 95% ethanol solution with a weight-volume percentage being 50%, followed by extracting at 50 to 80° C.; and concentrating the extracted product to obtain the herbal extract. The invention also discloses a method of treating liver cancer.Type: GrantFiled: October 31, 2014Date of Patent: March 1, 2016Assignee: KINGLAND REAL ESTATE CO., LTD.Inventors: Wei-Cheng Chen, Mei-Chou Lai, Shorong-Shii Liou, I-Min Liu
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Patent number: 9185849Abstract: A solid medium of Antrodia cinnamomea comprises 20 to 50 wt % soybean; 30 to 50 wt % coixseed; and 20 to 50 wt % sorghum. A culturing method of Antrodia cinnamomea, comprises providing a solid medium comprising soybean, coixseed and sorghum; preparing a solution of Antrodia cinnamomea, inoculating the solution of Antrodia cinnamomea on the solid medium in a concentration of 1×103 to 1×106 cfu on per 100 g of solid medium, and statically culturing the solution of Antrodia cinnamomea on the solid medium till obtaining hyphae adhered on the solid medium; and culturing the solution of Antrodia cinnamomea by intermittent shaking in a frequency of every 5 to 7 days shaking 5 to 10 minutes, with a period of the culturing by intermittent shaking being more than 40 days.Type: GrantFiled: December 18, 2012Date of Patent: November 17, 2015Inventors: Po-Lun Wang, Jung-Chi Hsieh, Ting-Yuan Lai, Jui-Lung Cheng
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Patent number: 9179693Abstract: A method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving dietary phosphorus absorption and retention, or for improving the efficacy of the phytase, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (FCR) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g. improving) the immune response of the subject or for reducing populations of pathogenic bacteria in the gastrointestinal tract of a subject, or for reducing nutrient excretion in manure, which method comprising administering to a subject at least one direct fed microbial in combination with a phytase, wherein the phytase is administered to the subject at a dosage of more than about 1500 FTU/kg feed.Type: GrantFiled: March 14, 2013Date of Patent: November 10, 2015Assignee: DuPont Nutrition Biosciences ApSInventors: Luis Romero, Peter Plumstead, Luke Barnard
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Patent number: 9161959Abstract: Use of a vegetable drug composition in the manufacturing of a pharmaceutical preparation for the treatment of portal hypertension caused by hepatocirrhosis, said preparation comprises 25-38% of extract of radix Salviae Miltiorrhizae, 20-25% of extract of herb Gynostemmae Pentaphylli, 1-6% of alcoholic extract of fructus Schisandrae Chinensis, 19-26% of extract of Cordyceps, 6-8% of extract of pollen Pini, 6-10% of extract of semen Persicae. Said preparation can improve hepatic cell degeneration, necrosis, intraheptic hemorrhage, fiber proliferation, and reduce pressure of portal vein in mammal. A preparation method of said preparation is disclosed.Type: GrantFiled: April 28, 2008Date of Patent: October 20, 2015Assignee: SHANGHAI SUNDISE CHINESE MEDICINE TECHNOLOGY DEVELOPMENT CO., LTDInventors: Lieming Xu, Cheng Liu, Ping Liu
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Patent number: 9144542Abstract: A composition for promoting hair growth in humans can include at least three of the following ingredients: Pygeum Africanum, Serenoa Repens, Ganoderma Lucidum, Piper Methysticum, and Zinc. The amount by weight of the identified ingredients in a particular formulation may range from at least 5% to no more than 50% of the formulation.Type: GrantFiled: February 21, 2014Date of Patent: September 29, 2015Assignee: Kay Jay, LLCInventor: Kevin Meehan
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Patent number: 9138450Abstract: The present invention provides methods for treating constipation-predominant irritable bowel syndrome comprising administering to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat constipation-predominant irritable bowel syndrome (c-IBS). Treatment of c-IBS includes the treatment of the constipation component of c-IBS as well as the pain and abdominal discomfort associated with c-IBS. In one embodiment, the polymeric proanthocyanidin compound is crofelemer. The present invention in an alternative embodiment also provides methods for treating alternating constipation-predominant/diarrhea-predominant irritable bowel syndrome.Type: GrantFiled: October 12, 2011Date of Patent: September 22, 2015Assignee: Napo Pharmaceuticals, Inc.Inventors: Barry D. Quart, David P. Rosenbaum
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Patent number: 9095143Abstract: A method for producing an antimicrobial agent, by cutting, or cutting and then milling a plant belonging to the family Juncaceae: mixing the cut plant with a nutrient source for a seed culture of mushroom mycelia, to form a mixture; inoculating the seed culture of mycelia to the mixture of the plant belonging to the family Juncaceae and the nutrient source and then culturing the seed culture at a growth temperature for the seed culture of mycelia to produce the antimicrobial agent.Type: GrantFiled: July 13, 2012Date of Patent: August 4, 2015Assignee: KABUSHIKI KAISHA OUJU SEIYAKUInventors: Masayoshi Iwahara, Hiroshi Morita, Kazuyuki Miyata
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Patent number: 9084736Abstract: The present invention relates to the use of an extract of Lentinus, as well as the pharmaceutical composition that contains it, within the scope of combating cellulite and subcutaneous accumulations of fat.Type: GrantFiled: January 22, 2010Date of Patent: July 21, 2015Assignee: CasterInventors: Jean-Christophe Choulot, Patrick Ales
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Patent number: 9060963Abstract: Methods and compositions for reducing and/or inhibiting inflammation by topical application of dermatocosmetic compositions comprising effective amounts of extracts of Coriolus versicolor that have been hydrolyzed by an acid protease, preferably Rhizomucor miehei, and thereafter rendered substantially devoid of acid-protease activity.Type: GrantFiled: December 14, 2011Date of Patent: June 23, 2015Assignee: Active Organics, Inc.Inventors: Michael Bishop, Elysiann Bishop, Walter Smith, Glen Gillis
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Patent number: 9056897Abstract: The present invention relates to a method for isolating acyclohexapeptide and to a novel crystalline form of caspofungin diacetate thus obtained.Type: GrantFiled: September 26, 2011Date of Patent: June 16, 2015Assignee: DSM SINOCHEM PHARMACEUTICALSInventors: Robertus Mattheus De Pater, Dhiredj Chandre Jagesar
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Publication number: 20150147351Abstract: The present invention relates to use of a composition in the manufacture of health care products or medicaments for prevention and treatment of allergic diseases. The composition is made from raw materials comprising 5 to 200 parts by weight of Ganoderma, 5 to 150 parts by weight of Radix Panacis Quinquefolii or Radix Et Rhizoma Ginseng, 1 to 90 parts by weight of fermented Cordyceps sinensis powder and/or 1 to 120 parts by weight of Cordyceps, or is a composition made from water and/or alcohol extracts of the above raw materials as active components. The allergic diseases include allergic rhinitis, allergic dermatitis, urticaria, and/or allergic asthma.Type: ApplicationFiled: May 27, 2013Publication date: May 28, 2015Inventors: Hongguang Zhong, Minzhi Yi, Jianzhong Lu
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Publication number: 20150147352Abstract: The invention relates to the combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, an enzyme potentiator, and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The invention also relates to the combination of sulforaphane or a derivative thereof and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The present invention also relates to the combination of a broccoli extract or powder and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The present provides compositions and methods relating to these combinations.Type: ApplicationFiled: July 3, 2013Publication date: May 28, 2015Inventors: Brian Cornblatt, Grace Cornblatt, Anton Bzhelyansky, Robert Henderson
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Publication number: 20150140029Abstract: Disclosed are the action and use of water extracts and polysaccharides from Fusarium oxysporums in immune enhancement, which belong to the field of biological pharmacy. The water extracts and polysaccharides from Fusarium oxysporums have a significant immune enhancement effect, which can promote the proliferation of macrophages, increase the phagocytic ability of macrophages, activate macrophages to release immunological active factors NO, IL-1? and TNF-? and can be used in lower immune function diseases and tumor adjuvant treatment.Type: ApplicationFiled: February 1, 2013Publication date: May 21, 2015Applicant: University of Macau, Av. Padre Tomas Pereira TaipaInventors: Shaoping Li, Kun Feng, Lanzhen Meng, Jing Zhao
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Publication number: 20150132280Abstract: A human dietary supplement comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theacrine-containing supplement include improvement of at least one of mood, energy, focus, concentration or sexual desire or a reduction of at least one of anxiety or fatigue.Type: ApplicationFiled: November 12, 2014Publication date: May 14, 2015Applicant: ORTHO-NUTRA, LLCInventors: Hector L Lopez, Shawn Wells, Tim N. Ziegenfuss
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Publication number: 20150125484Abstract: A composition for promoting hair growth is provided with fermented and distilled extracts of fermented and distilled extracts of ganoderma, fungus, grapes, sorghum, wheat, onions, ginger, burdock, aloe vera, carrot, rose, litsea, tea, whip grass, incense, sage, blue citrus, bergamot, rosmarinus officinalis, sesame oil tree, nutmeg, rosewood, orange, marigold, geranium, and honey flower. The composition can be made into shampoo.Type: ApplicationFiled: November 4, 2013Publication date: May 7, 2015Applicants: Li Ren Wang, Hua Guan Bio-tech CorporationInventor: Li Ren Wang
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Publication number: 20150104426Abstract: Disclosed is a composition for skin external application containing a Pleurotus ferulae fruiting body extract, a Pleurotus ferulae mycelium extract or a liquid culture obtained by culturing the Pleurotus ferulae mycelium. More specifically, disclosed is a functional composition for skin external application containing 0.001 to 90.0% by weight of a Pleurotus ferulae fruiting body extract, a Pleurotus ferulae mycelium extract or a liquid culture obtained by culturing the Pleurotus ferulae mycelium, with respect to the weight of the composition, wherein the composition is potently effective in scavenging active oxygen, preventing aging, acting wrinkles, facilitating collagen synthesis, moisturizing skin, whitening skin, reducing skin irritation, preventing acne, alleviating atopy, providing anti-inflammation, preventing hair damage, preventing alopecia and improving hair growth.Type: ApplicationFiled: January 27, 2014Publication date: April 16, 2015Applicant: AMI Cosmetic Co., Ltd.Inventors: Kyung Rok Lee, Il Hong, Do Gyeong Lee, Jung No Lee, Soo Yeon Choi, Nu Rim Lee
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Publication number: 20150093409Abstract: The present invention relates to topical compositions containing fermented extracts of Traditional Chinese Medicinal (TCM) ingredients for improving the appearance and skin condition of the user. The topical compositions of the present invention are tailored for different users of different skin compositions according to TCM principles. The fermented TCM extracts are characterized by reduced odor and/or color in comparison with unfermented TCM extracts and are therefore more suitable for use in cosmetic products.Type: ApplicationFiled: October 1, 2013Publication date: April 2, 2015Inventors: Jing Cheng, Chia-Wen Chen, Steven Francis Schnittger, Ming Lu
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Patent number: 8986758Abstract: Disclosed are: a method for extracting a traditional herbal medicine component comprising a process in which a traditional oriental medicine component is steamed together with polished rice; and a composition for an external application to skin comprising an extract which has been extracted by means of the method. The component extracted by means of the extraction method reduces the cytotoxicity of the traditional oriental medicine, is recognized as being effective in alleviating skin irritation, and exhibits an outstanding skin-whitening effect.Type: GrantFiled: November 17, 2010Date of Patent: March 24, 2015Assignee: Amorepacific CorporationInventors: Dong Hyun Kim, Ji Seong Kim, Hui Kyeung Chang, Duck Hee Kim, Han Kon Kim
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Patent number: 8986756Abstract: The present invention is related to a combined herb composition comprising herbs of Coriolus versicolor, Astragalus membranaceus Bunge, and additionally comprising at least one herb selected from group consisting of Schisandra chinensis, and Artemisia capillaris, according to the need for the prevention and treatment of liver disease and methods of using the above crude drug composition and pharmaceutical composition as hepato-protective agent.Type: GrantFiled: December 18, 2007Date of Patent: March 24, 2015Inventor: Jung Sik Lee
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Publication number: 20150079128Abstract: This invention relates to a Chinese medicinal formulation for the treatment of inflammatory bowel diseases, and a method of preparation thereof. The formulation comprises herbal components selected from a group consisting of Radix Codonopsis (Dangshen), Rhizoma Atractylodis Macrocephalae (Bai Zhu), Sclerotium Poriae Cocos (Fu Ling), Rhizoma Zingiberis Officinalis (Gan Jiang), Radix Paeoniae Alba (Bai Shao) and Rhizoma Coptidis (Huanglian).Type: ApplicationFiled: September 18, 2013Publication date: March 19, 2015Applicant: Hong Kong Baptist UniversityInventors: Zhaoxiang Bian, Siu Wai Tsang, Siu Po Ip, Che Yuen Justin Wu, Aiping Lu, Albert Sun Chi Chan
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Publication number: 20150050323Abstract: Disclosed herein are inventive stable homogenized biomass hetero-colloids, their production and uses. Such biomass hetero-colloids comprise biomass derived solid particle colloid matter and at least 15% (w/w) biomass derived soluble colloid matter. The novel biomass hetero-colloids provide an inventive approach for the application of biologically active compounds. Bio-actives are made available in an innovative form involving low intervention processing and enhancing the biological availability.Type: ApplicationFiled: April 19, 2013Publication date: February 19, 2015Inventor: Othmar KAEPPELI
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Publication number: 20150050315Abstract: The disclosure provides a method for modulating Th17 cells, including: administering an Antrodia cinnamomea (also named Antrodia camphorata or Taiwanofungus camphoratus) extract to a subject in need thereof, wherein the Antrodia cinnamomea extract has an effect of modulating Th17 cells. The Antrodia cinnamomea extract may include a fruiting body extract of Antrodia cinnamomea or a mycelium extract of Antrodia cinnamomea.Type: ApplicationFiled: July 3, 2014Publication date: February 19, 2015Inventors: I-Horng PAN, Shu-Fang WEN, Ming-Han LI, Hsin-Jan YAO, Hsin-Chieh WU, I-Huang LU, Joung-Liang LAN, Der-Yuan CHEN, Chi-Chien LIN, Ching LU
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Patent number: 8956624Abstract: Compositions for treating skin containing at least one extract from the genus Trametes and at least one viscosity enhancing synthetic polymer, and methods for whitening skin, treating skin for improvement, or treating skin disorders associated with pigmentation such as uneven pigmentation, skin mottling, or age spots or other dermatological disorders such as eczema, rosacea, hyperkeratinization, and so on.Type: GrantFiled: November 21, 2008Date of Patent: February 17, 2015Assignee: ELC Management, LLCInventors: Steven F. Schnittger, Daniel H. Maes, Michael Sullivan
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Publication number: 20150023906Abstract: A powder plant treatment formulation for application to plants by insect vectoring includes: a plant treatment agent; a stabilizing agent bonded to the plant treatment agent for stabilizing the plant treatment agent; a moisture absorption agent for absorbing moisture from the formulation; an attracting agent for attracting the formulation to plants; and a diluent.Type: ApplicationFiled: September 11, 2014Publication date: January 22, 2015Applicant: BEE VECTORING TECHNOLOGY INC.Inventors: Todd Gordon Mason, John Clifford Sutton
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Patent number: 8936788Abstract: A method and container for developing seedlings includes germinating the seeds and air pruning the seedlings to a depth of about 3 inches.Type: GrantFiled: June 7, 2013Date of Patent: January 20, 2015Assignee: Wayne Lovelace and Judy LovelaceInventors: Wayne Lovelace, Hugh Steavenson, Bob Suddarth
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Publication number: 20150017203Abstract: A combination product includes as active substances, at least an inhibitor of the HMG-CoA-reductase enzyme and citrulline, or a bioequivalent compound thereof, for treating excess weight or obesity and/or the accumulation of body fat. A cosmetic treatment method for improving or slimming the figure and/or for stimulating the loss of excess weight and/or of cellulite and/or for limiting the accumulation thereof, includes the administration of a combination product including as active substances, at least an inhibitor of the HMG-CoA-reductase enzyme or a physiologically acceptable salt thereof, and citrulline, or a bioequivalent compound thereof, or one of theirs analogues, and the renewal of the administration until the expected cosmetic effect is obtained. The combination product such as previously defined for improving or slimming the figure and/or for stimulating the loss of excess weight and/or of cellulite and/or for limiting the accumulation thereof is also described.Type: ApplicationFiled: February 28, 2013Publication date: January 15, 2015Applicants: UNIVERSITE PARIS DESCARTES, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRAInventors: Beatrice Morio-Liondore, Frederic Capel, Jean-Pascal De Bandt, Christophe Moinard, Luc Cynober
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Patent number: 8932602Abstract: Disclosed herein are compositions comprising an isolated cellulose degrading fungus and pharmaceutical substances produced by the fungus.Type: GrantFiled: August 11, 2011Date of Patent: January 13, 2015Assignee: Menon Renewable Products, Inc.Inventors: Suresh M. Menon, Samantha S. Orchard, Jessica Badger, Sara Guidi, David Newman, Jagadish C. Sircar, Kashinatham Alisala
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Patent number: 8932825Abstract: The present invention relates to host cells having modified lipid-linked oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified lipid-linked oligosaccharides are created or selected. N-glycans made in the engineered host cells have a GlcNAcMan3GlcNAc2 core structure which may then be modified further by heterologous expression of one or more enzymes, e.g., glycosyl-transferases, sugar transporters and mannosidases, to yield human-like glycoproteins. For the production of therapeutic proteins, this method may be adapted to engineer cell lines in which any desired glycosylation structure may be obtained.Type: GrantFiled: December 24, 2002Date of Patent: January 13, 2015Assignee: GlycoFi Inc.Inventors: Stefan Wildt, Robert Gordon Miele, Juergen Hermann Nett, Robert C. Davidson
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Publication number: 20140377303Abstract: Disclosed herein are compositions comprising an isolated cellulose degrading fungus and pharmaceutical substances produced by the fungus.Type: ApplicationFiled: June 19, 2014Publication date: December 25, 2014Inventors: Suresh Menon, Samantha S. Orchard, Jessica Badger, David Lipson, Sara Guidi, David Newman, Jagadish C. Sircar, Kashinatham Alisala
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Publication number: 20140370048Abstract: The present invention relates to a composition for the treatment or prevention of hyperlipidemia, the composition containing alcohol extracts of Oligoporus tephroleucus as an active ingredient, and to a medicine and a dietary supplement, containing the extracts.Type: ApplicationFiled: December 7, 2012Publication date: December 18, 2014Inventors: Sung Ho Ryu, Hyeongji Lee, Taehoon Lee, Jaeyoon Kim, Jong-Vong Eun, Kang-Ha Kim, Sang-Gap Shim, Woo-Jae Cheon
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Publication number: 20140370047Abstract: The invention relates to fungal cells and spores, as well as extracts of either, for use, in particular, in prevention or treatment of Chlamydia, or Helicobacter pylori or other infections, inflammation, inflammatory, lysosomal, acidic, SOD- or IgG or other immunoglobulin—peroxidases or hydrogen peroxide induced or other forms of oxidative damage, atherosclerosis, heart disease, stomach, intestinal and liver inflammatory conditions and their complications, promoting or stimulating regeneration or healing of wounds, burns, ulcers, or other forms of damaged or aged tissues, or in reducing elevated cholesterol and/or triglycerides levels In a preferred instance, the fungal cells or spores are those used in the manufacture of fungal fermented cheeses or other food stuff or beverages, particular fungal blue or white cheeses.Type: ApplicationFiled: September 6, 2012Publication date: December 18, 2014Applicant: IP SCIENCE LIMITEDInventor: Ivan Petyaev
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Publication number: 20140363379Abstract: Nutritional products, including food and/or beverage compositions, pharmaceutical and cosmetic preparations and methods of use are disclosed for the prevention, suppression and treatment of skin, hair, and nail conditions for the improvement of skin, hair and nail growth through the identification and/or use of stem cells, as well as maintenance of healthy tissues. Uses of Ergothioneine and/or Vitamin D to neutralize free radicals, and improve skin, hair and nail growth are disclosed.Type: ApplicationFiled: December 21, 2012Publication date: December 11, 2014Inventor: Marvin S. Hausman
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Patent number: 8906361Abstract: A dietary supplement based on blue green algae, phycocyanin and phenylethylamine is fortified with one or more of curcumin, silymarin, resveratrol, astragalus root extract, astragoloside IV, vitamin D3, vitamin C, anhydrous trimethylglycine and brewer's yeast to stimulate stem cell production and reduce the rate of telomere reduction or shortening. This can result in the repair of existing body cells and enhance longevity by stimulating the production of new stem cells and maintaining the telomeres on new stem cells as well as existing cells. The dietary supplement supports an increased life span by enhancing metabolic function, activating SIRT-1 anti-aging genes, and encouraging the production of new cells with longer telomeres.Type: GrantFiled: January 24, 2012Date of Patent: December 9, 2014Inventor: John V. Cappello
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Publication number: 20140356394Abstract: The present invention relates to a composition for the treatment or prevention of obesity, the composition containing water extracts of Fomitella fraxinea as an active ingredient, and to a medicine and a dietary supplement, containing the extracts.Type: ApplicationFiled: December 7, 2012Publication date: December 4, 2014Inventors: Sung Ho Ryu, Hyeongji Lee, Taehoon Lee, Jaeyoon Kim, Jong-Vong Eun, Kang-Ha Kim, Sang-Gap Shim, Woo-Jae Cheon
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Publication number: 20140356393Abstract: The present invention relates to a composition for the treatment or prevention of hyperlipidemia, the composition containing water extracts of Laetiporus sulphureus as an active ingredient, and to a medicine and a dietary supplement, containing the extracts.Type: ApplicationFiled: December 7, 2012Publication date: December 4, 2014Inventors: Sung Ho Ryu, Hyeongji Lee, Taehoon Lee, Jaeyoon Kim, Jong-vong Eun, Kang-Ha Kim, Sang-Gap Shim, Woo-Jae Cheon
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Publication number: 20140341973Abstract: A micron Taiwanofungus camphoratus liposome structure which includes a first and a second liposome shell is provided. The external radius of the first liposome shell is smaller than the internal radius of the second liposome shell, and the second liposome shell encloses the first liposome shell. A first space is defined inside of the first liposome shell, and a second space is defined between the inside surface of the second liposome shell and the outside surface of the first liposome shell. A plurality of cup-shaped structures is formed on the outside surface of the second liposome shell. Each cup-shaped structure is consisted of algae sugar and beta-cyclodextrin. The first space and the second space are for containing a first and a second active substance respectively. The Taiwanofungus camphoratus liposome structure contains active substances with different effects, such that the storage and transportation of multi-active substances is improved.Type: ApplicationFiled: February 21, 2014Publication date: November 20, 2014Inventor: Hsu-Shen Wu
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Publication number: 20140342048Abstract: Sauces, spreads, cooking oils, and cooking fats are created from a wide range of various ingredients. Sauces, spreads, cooking oils, and cooking fats having at least one ingredient, with at least one flavoring, and at least one texture. At least one ingredient is selected from group including of at least one flavoring ingredient, at least one nutritional ingredient, at least one health ingredient, and at least one other ingredient. At least one ingredient is also created as small spherical balls as mixed in. Sauces can be served as appetizer and snack. And served as baby food, for children with less teeth, for old people, and for sick people. Sauces, spreads, cooking oils, and cooking fats are used for food preparation and food flavoring, including condiment and salad dressing. And used in manner selected from group consisting of room temperature, cold, warm, and hot.Type: ApplicationFiled: November 26, 2013Publication date: November 20, 2014Inventor: Alice Chang
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Publication number: 20140342010Abstract: The present invention provides a method of using Polygonum multiflorum or extracts thereof to enhance stem cell mobilization in a subject, including hematopoietic stem cells (HSCs) and bone marrow stem cells (BM-SCs). In one embodiment, a blended composition of plant parts, fruits, mushrooms, microorganisms, maternal fluids, and extracts thereof are used to promote mobilization of stem cells, resulting in migration of the stem cells to specific sties of maintenance and repair within tissues and/or organs. Increased circulation of HSCs and/or BMSCs and migration towards sites of maintenance promotes the natural regeneration mechanisms in the body.Type: ApplicationFiled: November 15, 2012Publication date: November 20, 2014Applicant: Stemtech International, Inc.Inventors: Christian Drapeau, Gitte S. Jensen
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Publication number: 20140335122Abstract: Disclosed is a compound isolated from Antrodia camphorata, represented by formula I: wherein R1 is a hydrogen atom or an acetyl group; and a method of inhibiting cancer cell growth by using the compound, the cancer is selected from the group consisting of lung cancer, colon cancer, prostate cancer, liver cancer and breast cancer.Type: ApplicationFiled: August 6, 2013Publication date: November 13, 2014Inventor: HUI LING TSENG
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Patent number: 8883167Abstract: A preparation method for an ethanol extract of the fruiting body of Antrodia camphorata (EEAC) is provided. The preparation method includes steps of: (a) providing the fruiting body of A. camphorata (AC); (b) extracting the fruiting bodies with a first ethanol solution; and (c) obtaining EEAC. EEAC further can be sequentially extracted or fractioned by n-hexane, ethyl acetate and ethanol, and an n-hexane fraction (FC), an ethyl acetate fraction (FA) and an ethanol fraction (FB) respectively are generated. The growth inhibition and apoptosis induction of leukemia cell line HL 60 are effectively mediated by FA product, in which zhankuic acid A is the bioactive marker. The amount of triterpenoid in the fruiting body of AC can be determined by NMR and HPLC analysis.Type: GrantFiled: February 16, 2012Date of Patent: November 11, 2014Assignee: Kaohsiung Medical UniversityInventors: Yang-Chang Wu, Mei-Chin Lu, Fang-Rong Chang, Ying-Chi Du, Tung-Ying Wu