Abstract: Cast pellets containing plants seeds and methods of making the cast pellets are described. The cast pellets include a mixture of one or more plant seeds and a setable, flowable casting substance. The casting substance can be a thermoplastic or another material such as plaster, polyacrylamide or a derivative thereof, polyacrylic acid, a melt processable starch, wax, polyvinyl alcohol, glyceride, partial glyceride, or mixtures thereof. The mixture can additionally contain other substances, such as fillers, plant growth regulators, insecticides, fungicides, bactericides, fertilizers, microorganisms, or mixtures thereof. The seeds can be of the same or different species, and can be selected to have, for example, the same or different flower colors.

Abstract: Disclosed are: a composition for hard tissue repair with excellent penetrability to an adherend such as a cancellous bone and excellent adhesion to an adherend, which comprises a monomer (A), a polymer powder (B) comprising 54% by mass or more of a polymer powder (b1) having a volume mean particle diameter of 27 to 80 ?m and a polymerization initiator (C); and a kit for hard tissue repair comprising members in which the components of the monomer (A), the polymer powder (B) and the polymerization initiator (C) contained in this composition for hard tissue repair are encased in three or more divided groups in an optional combination.

Abstract: A process for producing a coated particle to provide controlled release characteristics. In this process the mixing of the substrate and coating is made in a mixing device and that mixture is then transferred to a reactor vessel different from the mixing device where the chemical curing of the coating over the particles takes place. Several layers of coating can be applied by repeating the steps and it can be run in a fully continuous manner.

Abstract: A method for precisely applying chemicals targeted by digital maps developed from remotely sensed data, including: obtaining EOS data through a growing season of a crop growing in a field; processing the EOS data to reflectance values, removing error-inducing effects of atmospheric alteration from the processed EOS data; calculating from the processed EOS data a crop performance index that indicates one or more poor performing area of the field; generating one or more maps of the crop performance index to allow a user to determine whether each of the one or more poor performing areas of the field are due to biological pests instead of topographic or soil constraints in discrete locations of the field; guiding the user to the one or more poor performing areas of the field using the one or more maps to allow the user to scout the one or more poor performing areas of the field to confirm and identify the biological pests; and providing guidance for a chemical application at the one or more poor performing areas

Abstract: A new approach to targeting imaging agents to macrophage-rich sites of interest is disclosed. Compositions of the invention are rHDL and HDL-like liposomal compositions, protein constituents of which, apolipoproteins A-I and/or A-II or fragments thereof are used not only as structural but also as targeting agents. This is achieved by certain controlled chemical or enzymatic modification of apolipoproteins A-I or A-II or fragments thereof. Such modification converts these apolipoproteins to substrates for macrophage scavenger receptors and results in the improvement of contrast agent-(HDL/modified apolipoprotein)-particle association with macrophages and/or absorption (uptake) by macrophages when compared to that of the contrast agent-(HDL/apolipoprotein)-particle constructed with non-modified naturally occurring apo A-I.

Abstract: A wellbore cement composition that includes a cross-linked polyamide. The polyamide is formed by reacting a di-functional amine with an aromatic tri-functional carboxylic acid. The wellbore cement composition is created by blending cement and water with the polyamide and then allowed to cure. Increases in compressive strength, Young's Modulus, and Poisson's Ratio of the cement were realized by adding the polyamide to the cement composition.

Abstract: Methods of fabricating a natural pesticide structure include obtaining at least one raw material; forming at least one natural pesticide building material from the at least one raw material by applying at least one natural pesticide substance to the at least one raw material, the at least one natural pesticide substance having intrinsic pesticide properties and including any combination of the following: garlic, lavender, gardenia, peppermint, wintergreen and lemon grass; and fabricating a natural pesticide structure from the at least one natural pesticide building material. Natural pesticide structures are also disclosed.

Abstract: Disclosed are polymers suitable for hydrophilically modifying the surface of porous fluoropolymer supports, for example, a copolymer of the formula: Also disclosed are a method of preparing the polymers, a method of hydrophilically modifying porous fluoropolymer supports, hydrophilic fluoropolymer porous membranes prepared from the polymers, and a method of filtering fluids through the porous membranes.

Abstract: A process for making microcapsules may include i) forming a solution of a cross-linker in a liquid; ii) forming a slurry of a surface-modified particulate inorganic material in an aqueous medium; and iii) dispersing the solution of step i) in the slurry of step ii) and causing or allowing the cross-linker to react with the surface-modified particulate inorganic material so as to form a cross-linked microcapsule wall.

Abstract: The present invention relates to a pharmaceutical cocktail and methods of treatment involving said cocktail, in particular, a combination of effective amounts of a carbonic anhydrase inhibitor, in combination with effective amounts of an angiogenesis inhibitor, including a vascular endothelial growth factor (VEGF) inhibitor such as bevacizumab for the treatment of cancer. In other embodiments, it relates to compositions and methods of treating cancer involving effective amounts of a carbonic anhydrase inhibitor. Pharmaceutical compositions and methods of treating cancer (eliminating the tumor, shrinking the tumor, prolonging the life of the patient, increasing quality of life by decreasing the grade of adverse events seen with other cancer treatments, and/or preventing/reducing the likelihood of the tumor's metastases) are additional aspects of the present invention.

Abstract: The present invention is a composition comprising a stable aqueous dispersion of polymer particles and a sorbate ester, which is a liquid at 20° C. and has a molecular weight in the range of 125 to 500 g/mol. The composition of the present invention provides a way to enhance film formation of coatings prepared using relatively high Tg latexes without the aid of high volatile organic content (VOC) coalescents.

Abstract: The present invention relates to a material as interpenetrating polymer network (IPN) associating a gel with a co-network of functionalized synthetic polymer and functionalized protein as well as a method of the manufacture of such a material. In particular, the invention relates to a material as interpenetrating polymer network associating a fibrin gel with a co-network of polyvinylalcohol and albumin thank to methacrylate bridges, with improved biodegradability properties.

Abstract: The present invention relates to a pharmaceutical cocktail and methods of treatment involving said cocktail, in particular, a combination of effective amounts of a carbonic anhydrase inhibitor, in combination with effective amounts of an angiogenesis inhibitor, including a vascular endothelial growth factor (VEGF) inhibitor such as bevacizumab for the treatment of cancer. In other embodiments, it relates to compositions and methods of treating cancer involving effective amounts of a carbonic anhydrase inhibitor. Pharmaceutical compositions and methods of treating cancer (eliminating the tumor, shrinking the tumor, prolonging the life of the patient, increasing quality of life by decreasing the grade of adverse events seen with other cancer treatments, and/or preventing/reducing the likelihood of the tumor's metastases) are additional aspects of the present invention.

Abstract: A seal comprises: a first portion including a crosslinked product of: a first crosslinked polymer; and a second crosslinked polymer; and a second portion including a polymer which is different than a constituent polymer in the first portion, wherein the seal has a gradient in glass transition temperature. A method for sealing comprises: disposing the seal of Claim 1 in an opening; heating the seal to a temperature greater than a minimum value of the glass transition temperature of the gradient; and applying pressure to an elastic portion of the seal for sealing the opening.

Abstract: New compositions and methods are described for modulating the rate of conversion of ethylene bisdithiocarbamate fungicides, such as mancozeb, into ethylene bis-isothiocyanate sulfide (EBIS).

Abstract: A process for making microcapsules comprising i) forming a solution of a cross-linker in a liquid; ii) forming a slurry of a surface-modified particulate inorganic material in an aqueous medium; and iii) dispersing the solution of step i) in the slurry of step ii) and causing or allowing the cross-linker to react with the surface-modified particulate inorganic material so as to form a cross-linked microcapsule wall.

Abstract: Use of formulations comprising polyurea microcapsules obtainable by interfacial polymerization of diphenylmethylen-4,4?-diisocyanate (MDI), optionally in admixture with polymethylenepolyphenylisocyanate (PAPI), said formulations having a prolonged knockdown and killing effect longer than at least 3 months, preferably at least of 6 months, still more preferably at least of 9 months from the application, wherein the microcapsules comprise: an active principle selected from the pyrethroid and/or neonicotinoid classes, synergizing agents selected between PEO and Verbutin, the concentration of the active principle in the microcapsule as % by weight on the total of the microcapsule is comprised between 1 to and 60% the average diameter of the microcapsules is comprised between 2 and 50 ?m.

Abstract: Microparticles containing an ultraviolet light absorbing polymer and 3-iodo-2-propynyl butylcarbamate (“IPBC”) resist discoloration by sunlight and other ultraviolet light sources. Methods for preparing the microparticles produce polymer-shielded, formaldehyde-free IPBC formulations which resist discoloration and leaching, and are especially useful in water-based applications. The microparticles include a polymer or a poly(vinyl formal) homopolymer that absorbs light over a range of ultraviolet wavelengths associated with IPBC discoloration. The microparticles may be utilized in paints, stains, stuccoes, adhesives, and plastics, for example.

Abstract: A composite that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 ?m, 50 nm to 10 ?m, 100 nm to 5 ?m, or 1 ?m to 10 ?m. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.

Abstract: There is provided a microcapsule for plant disease control in which a core material containing a fungicidal active ingredient is enclosed within a shell material; wherein the microcapsule satisfies the following conditions (1) and (2), is a formulation that withstands physical impacts, drying and diluting, and is suitable for seed treatment using a stirring type machine, and the durability of control of diseases of crops and the safety for the crops can be improved more efficiently by the microcapsule of the present invention; Condition (1): D50/T?230; Condition (2): (D90?D10)/D50?2.5; and wherein in the formulae of conditions (1) and (2), T represents the shell thickness (?m) of the microcapsule, and D10, D50 and D90 respectively represent the 10%, 50% and 90% cumulative volume particle diameter (?m) of the microcapsule.

Abstract: A composition is provided with increased release comprising an encapsulated active and one or more metal additive. Also provided is a coating composition comprising an encapsulated active, and one or more metal additive, and one or more binder polymer, one or more binder precursor, or a mixture thereof, and one or more pigment. Also provided is a method of making such compositions. Also provided is a method of providing a surface that resists marine fouling wherein said method comprises applying a layer of such compositions to a substrate and drying said layer or allowing said layer to dry.

Abstract: A water dispersible granule composition comprising microcapsules comprising at least one agrochemical active ingredient encapsulated within a urea formaldehyde polymeric shell wall, at least one inert filler and at least one agrochemical excipients.

Abstract: The present Invention deals with an alternative Interfacial polymerization process of microencapsulation, microcapsule's produced thereof, microencapsulated agrochemicals, pharmaceuticals, catalysts and phase transfer materials, and formulations thereof, by means of microcapsules and starting materials with the participation of acetylene carbamide derivatives in the final structure of the microcapsules' wall.

Abstract: A product comprising microcapsules which themselves comprise (a) a polymeric shell; and (b) a core which comprises (i) a solid agrochemical dispersed in a matrix and (ii) a water-immiscible liquid characterized in that the matrix is distributed non-continuously throughout the water-immiscible liquid.

Abstract: The present invention concerns antimicrobial expandable polystyrene (EPS) beads, comprising as main antimicrobial agent metal ions selected from silver and copper and combinations thereof, which antimicrobial agent(s) may be either mixed into the polymer matrix or coated onto the beads. The invention also concerns a method for producing the coated form of these antimicrobial beads.

Abstract: A microcapsule comprising A) a core containing a hydrophobic liquid or wax, B) a polymeric shell comprising a) a polymer formed from a monomer mixture containing: i) 1 to 95% by weight of a hydrophobic mono functional ethylenically unsaturated monomer, ii) 5 to 99% by weight of a polyfunctional ethylenically unsaturated monomer, and iii) 0 to 60% by weight of other mono functional monomer, and b) a further hydrophobic polymer which is insoluble in the hydrophobic liquid or wax. The invention includes a process for the manufacture of particles and the use of particles in articles, such as fabrics, and coating compositions, especially for textiles.

Abstract: An article, such as a container or bag for garbage, or electrical wiring insulation, which repels animals such as cats, dogs, rodents, and crows. The article is made from a synthetic resin composition including a thermoplastic polymer, and from 10 to 15,000 ppm by weight of an odorant compound such as a salicylic acid ester, menthol, corn mint oil, eucalyptus oil, and camphor, and combinations thereof. The resin composition may comprise more than one thermoplastic polymer, polyethylene and ethylene/vinyl acetate copolymer being preferred first and second thermoplastic polymers, respectively. In a method for forming the synthetic resin composition, the compound is added to the second polymer in a ratio of about 1:2 parts by weight to form a master blend that then is added to an amount of the first polymer at a master blend percentage of about 1.5%.

Abstract: A system of stabilized metallic nanoparticles is described that includes metallic nanoparticles coated with a hydrophilic polymer that has been reacted with a catechol-based ligand. Also described are stable, metallic nanoparticles that can be used alone or in conjunction with biocides, antibiotics, or other treatment systems in a method to disrupt a biofilm and facilitate its removal from a surface. The nanoparticles can be metal, such as platinum, silver, iron (II, III) oxide (Fe3O4), and gold. The nanoparticles can be sterically stabilized, such as with a polymer, or charge stabilized, such as with citrate, resulting in nanoparticles having modified surfaces. This surface modification is thought to enhance the stability of the nanoparticles and decrease their likelihood of aggregation, which, in turn, enhances their ability to disrupt and disperse existing biofilms.

Abstract: Microcapsules possessing Lewis acid-Lewis base salt walls incorporate water-immiscible materials, such as N,N-di-ethyl-m-toluamide (DEET), as a core component. Such microcapsules, or similar microcapsules incorporating other core components, may be made by emulsifying a water-immiscible core component in an aqueous solution of one wall-forming reactant, such as the Lewis base, and then mixing that solution with the other wall-forming reactant, such as the Lewis acid. Various adjuvants may be included with the core component to contribute additional characteristics, such as enhancement of a controlled release characteristic or improved mechanical stability.

Abstract: Methods and compositions for producing hydrogel capsules enveloped with at least one coating layer is disclosed. The coating formulations deposited on the surface of the capsules can improve the physical integrity and the water-retention properties of the alginate beads. The coating formulations can be sequentially applied in various combinations to obtain desirable properties, such as improved physical integrity, mechanical strength, and low permeability, that can extend the shelf-life of the capsules when incorporated into various consumer products.

Abstract: A liquid composition having a microcapsule, the microcapsule having an aldehyde-containing resin, and one or more formaldehyde scavenger which reacts with formaldehyde to achieve more than about 60% reaction completeness in about 15 minutes time at pH 8 and at about 21° C. A liquid composition having a microcapsule, the microcapsule having an aldehyde-containing resin, one or more sulfur-based formaldehyde scavenger and optionally a non-sulfur-based formaldehyde scavenger.

Abstract: A personal cleansing composition includes a surfactant, a thickener, emulsifier and at least one particulate dispersed in the thickener, the at least one particulate being formed of a substantially biodegradable substance. The at least one particulare may include a soy meal based polymer. The soy meal based polymer is both stable and biodegradable. The at least one particulate includes a group of suspended particles added to mechanically scrub the skin of a user or used as a textural ingredient to modify the feel, spreadability or slip of a product. The soy meal based polymer is useful in personal cleansing compositions as an exfoliant, a scrub, a film former or as a filler. The half-life of the composition may be modified as necessary based on the shelf-life of the product.

Abstract: An agent for virus inactivation capable of exhibiting inactivation action based on structural destruction such as degradation and decomposition against viruses, which comprises a monovalent copper compound such as cuprous oxide, cuprous sulfide, cuprous iodide, and cuprous chloride as an active ingredient, and a virus inactivation material, which contains the agent for virus inactivation on a surface of a substrate and/or inside of the substrate.

Abstract: Time-release algae-resistant roofing granules have a base particle including an algaecide and an outer coating layer including another algaecide. The at least two algaecides are released over different predetermined periods. The outer layer protects the base particle from exposure to the environment for a predetermined period, then fails catastrophically so that the interior algaecide can be released.

Abstract: The present invention provides an environmentally compatible, pesticidal composition and method for the control of insect pests. The composition includes two components. The first component is a chelating agent, a metal complex of a chelating agent, and mixtures thereof, and the second component is preferably a carrier material.

Abstract: A composite that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 ?m, 50 nm to 10 ?m, 100 nm to 5 ?m, or 1 ?m to 10 ?m. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.

Abstract: The invention relates to active particles, including core-shell particles, having low burst, controllable, sustained release which are useful for coating seeds. The active particles can also be used in sprayable and dry formulations for treating soil or plants. The particulate coating can also contain inert organic or inorganic material. The invention also relates to methods for preparing the active particles. The methods include: adding additional material to core particles to form a shell, removing active ingredient from a core surface to create an active-depleted shell, and crosslinking the outer layers of a core to form a shell.

Abstract: Bioactive substances are imbedded or mixed into functionalized matrices to form homogenous water-insoluble solid complexes with desirable field properties such as reduced leaching in soil, improved leaf retention (rainfastness), selective unloading to roots and convenient packaging and application. Bioactive substances that may be so complexed include pharmaceutical agents and pesticides including herbicides, insecticides, bacteriocides, rodenticides, nematicide and fungicides. The matrices comprise either a monomeric-, oligomeric- or (co)polymeric backbone which may be derivatized with chemical groups that exhibit ionic (amines, carboxyls), hydrophobic, and ligand-binding interactions to form the matrix of the formulation. The various matrices may be mixed with additives or modifiers, grafted, or fused to obtain optimal properties. The matrix/pesticide formulations may be applied as granules, as suspensions, emulsions in sprays, as foams, or as coats for seeds and fertilizers.

Abstract: An improved phenylbutazone carrier composition provides increased palatability to horses. Additionally, the composition improves the bioavailability of the phenylbutazone and thus increases the horse's blood plasma levels of the medicine for the same effective dosage of the medicine.

Abstract: Stabilized liquid agrochemical compositions are provided that comprise flowable, aqueous dispersion concentrates comprising a) a continuous aqueous liquid phase; b) at least one dispersed, solid phase comprising a dispersion of polymer particles having a mean particle size of at least one micron, wherein the outside surfaces of the particles comprise a colloidal solid material and wherein the particles have at least one agrochemically active ingredient distributed therein, optionally a non-porous particulate mineral that acts as a diffusion barrier to slow the release of the active ingredient, and optionally at least one non-cross-linkable mobile chemical such that the extraction of this chemical from the disperse phase renders it porous in a manner that allows the active ingredient to diffuse out. The colloidal solid is used to stabilize the polymenzable resin in an emulsion state during preparation.

Abstract: A method to control, inhibit, and kill pathogens and normal microbial strains that includes, but not limited to plant, animal and human pathogens, biofilm forming microbes, biofouling microbes, algae, fungi, bacteria, virus and protozoa using natural SL, MSL derivative and combinations thereof encompassed by the combination invention.

Abstract: [Problem] Provision of sustained release microparticles having excellent characteristics, in which the microparticles for supporting a substance or substances can fully control the release of the supported substances, can sufficiently diffuse the supported substances in a medium such as water, and can effect sustained release of more than one kind of the supported substances differing in water solubility, each at the respectively desired rate; and also to provide preparations which contain said sustained release microparticles. [Means of Solution] Sustained release microparticles comprising a supported substance, microgranular form and coating agent, said microgranular form having an average particle size within a range of from 20 to 300 ?m; and preparations which contain the sustained release microparticles.

Abstract: The invention provides a method of enzymatically modifying xylan by selectively removing glucuronic acid and/or arabinose side chains from the xylan with a-D-glucuronidase and/or a-L-arabinofuranosidase, and allowing the modified xylan to form into a hydrogel when the xylan becomes insoluble. A bioactive substance, such as a protein, enzyme, antimicrobial agent, bactericide or pharmaceutical compound can be added to the xylan so that the substance is encapsulated within the hydrogel or incorporated onto its surface. The hydrogel can be used as a drug delivery agent, such as for sustained-release or targeted drug delivery, rectal drug delivery or a dressing for a wound, burn or scar. The hydrogel can also be used as a coating, such as on medical gloves, catheters, surgical drainage systems, utensils or the like, or can be used in a scaffold for tissue engineering.

Abstract: It is an object of the present invention to provide a copper ion-producing composition that has a copper ion (mineral)-based germicidal activity against Legionella spp., Escherichia coli, Staphylococcus aureus, and saprophytic bacteria occurring in the water in drinking water storage tanks, hot springs, bathhouses, and pools, and that can supply mineral, and also to provide a granular composition that contains this copper ion-producing composition. The copper ion-producing composition is obtained by mixing 0.3 to 10 weight parts surfactant with 100 weight parts metallic copper powder. The granular composition is obtained by kneading this copper ion-producing composition with poorly water-soluble material that has a softening point of not less than 70° C. The granular composition is also obtained by coating the copper ion-producing composition on the surface of poorly water-soluble material that has a softening point of not less than 70° C.

Abstract: This disclosure concerns the control of the retention and/or persistence of a biologically active compound (e.g., a pesticide) in soil. In some embodiments, the use of polymer-coated particles comprising a biologically active compound leads to increased persistence of the compound in a target zone to which a composition comprising the particles is applied.

Abstract: A coated granular material of the present invention includes: a water-soluble granular substance; a coating layer applied to at least a surface of the water-soluble granular substance and containing a thermosetting resin A formed from a resin liquid having a molar ratio A of isocyanate groups to hydroxyl groups of 0.5 to 0.99; and a protection layer applied to the coating layer and containing a thermosetting resin B formed from a resin liquid having a molar ratio B of isocyanate groups to hydroxyl groups of 0.75 to 2.0, wherein the molar ratio B of the protection layer is greater than the molar ratio A of the coating layer. The present coated granular material is capable of achieving both of a short-term release pattern and an initial release limiting function and maintaining good quality.

Abstract: A personal cleansing composition includes a surfactant, a thickener, emulsifier and at least one particulate dispersed in the thickener, the at least one particulate being formed of a substantially biodegradable substance. The at least one particular may include a soy meal based polymer. The soy meal based polymer is both stable and biodegradable. The at least one particulate includes a group of suspended particles added to mechanically scrub the skin of a user or used as a textural ingredient to modify the feel, spreadability or slip of a product. The soy meal based polymer is useful in personal cleansing compositions as an exfoliant, a scrub, a film former or as a filler. The half-life of the composition may be modified as necessary based on the shelf-life of the product.

Abstract: Embodiments of the invention are directed to a composition having antimicrobial activity comprising particles comprising at least one inorganic copper salt; and at least one functionalizing agent in contact with the particles, the functionalizing agent stabilizing the particle in a carrier such that an antimicrobially effective amount of ions are released into the environment of a microbe. The average size of the particles ranges from about 1000 nm to about 4 nm. Preferred copper salts include copper iodide, copper bromide and copper chloride. Preferred functionalizing agents include amino acids, thiols, hydrophilic polymers emulsions of hydrophobic polymers and surfactants.

Abstract: A method for obtaining non-water-soluble powders comprising antimicrobial activity and having quaternary ammonium salts adhered thereto. The invention also includes the powders thus obtained and the use thereof as antibacterial agents. The invention enables the production of non-soluble organic or inorganic powders having a particle size of 5 to 500 ?m, having a quaternary ammonium salt adhered to the surface thereof and fixed on the surface. When deposited on textile materials, the powders enable bacterial and viral decontamination, by means of filtration, of polluted water or aqueous environments. Textile materials impregnated with powders according to the invention can be used in the production of breathing masks, protective garments or other items, in particular in a hospital environment. The antibacterial properties of the powders are at least twice as high as the antibacterial properties of the same quaternary ammonium salt used in isolation.

Abstract: Nanoparticle (e.g., quantum dot) compositions and methods for delivery of substances (e.g., microbicies, fungicides, pesticides, therapeutic agents, biologics, diagnostic agents, dyes, marker substances or tags, etc.) to desired locations within plants or animals. In some embodiments, the quantum dot or naoparticle may be substantially free of cadmiun. In some embodiments, the methods may be employed to prevent to treat fungus or fungus-like infections in pains, such as agricultural crops.