Errodable, Resorbable, Or Dissolving Patents (Class 424/426)
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Patent number: 9051204Abstract: The invention relates to a nontoxic polysiloxane material and ripened polysiloxane material which has been formed using one or more different polysiloxane materials. According to the invention, such a ripened polysiloxane material can be spun, for example, into bioabsorbable and/or bioactive fibers and then be further processed into fibrous nonwoven webs.Type: GrantFiled: December 9, 2008Date of Patent: June 9, 2015Assignee: BAYER INNOVATION GMBHInventors: Walther Glaubitt, Anja Ehrig
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Patent number: 9050274Abstract: Effective compositions and methods for treating an intervertebral disc are provided. The compositions and methods comprise a bulking agent or sealing agent, the bulking agent or sealing agent adapted to be administered at or within the intervertebral disc, the bulking or sealing agent having a drug depot comprising an effective amount of a therapeutic agent disposed therein, wherein the drug depot is capable of releasing an effective amount of the therapeutic agent over a period of at least one day.Type: GrantFiled: January 28, 2010Date of Patent: June 9, 2015Assignee: Warsaw Orthopedic, Inc.Inventors: Sean M. Haddock, Susan J. Drapeau, Thomas Andrew Simonton
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Patent number: 9044162Abstract: A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. At least one elongated fibrous marker body is slidably disposed within the inner lumen of the elongated delivery cannula. The at least one elongated fibrous marker body includes a plurality of bioabsorbable polymeric strands. The strands are compressed to a compressed configuration and bound together in the compressed configuration with a polymer binding agent prior to insertion into the elongated delivery cannula.Type: GrantFiled: January 25, 2013Date of Patent: June 2, 2015Assignee: SenoRx, Inc.Inventors: Michael L. Jones, Paul Lubock, John Merritt
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Publication number: 20150147379Abstract: The embodiments relate generally to medical devices and to methods of their manufacture. One aspect provides devices including chitosan fibers that are a free of chemical cross linking. Another aspect provides a method of manufacturing such devices.Type: ApplicationFiled: November 18, 2014Publication date: May 28, 2015Applicant: COOK MEDICAL TECHNOLOGIES LLCInventor: Mohammad Z. Albanna
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Patent number: 9040072Abstract: A composite having a poly(ethylene-co-acrylic acid) coupling agent, a filler, and a biocompatible, biodegradable polymer matrix is disclosed. The composites are useful for biomedical applications such as, tissue engineering, drug delivery, and implantable medical devices.Type: GrantFiled: December 7, 2007Date of Patent: May 26, 2015Assignee: ETHICON, INC.Inventors: Yue Zhou, Kevin Cooper, Yufu Li, Zhigang Li
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Patent number: 9040073Abstract: The invention provides formulations comprising adenosine in a silk fibroin-based, sustained-release delivery system. The formulations provide sustained, focal release of adenosine at therapeutic levels for the treatment of epilepsy and/or the prevention of epileptogenesis.Type: GrantFiled: May 15, 2009Date of Patent: May 26, 2015Assignee: Trustees of Tufts CollegeInventors: Detlev Boison, David L. Kaplan
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Patent number: 9040074Abstract: A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.Type: GrantFiled: July 19, 2012Date of Patent: May 26, 2015Assignee: Theracoat Ltd.Inventors: Asher Holzer, Dorit Daniel, Michael Mullerad, Jaime De La Zerda, Uri Shpolansky, Nadav Malchi, Yosh Dollberg, Dor Tal, Yossi Yavin, Marina Konorty
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Patent number: 9028871Abstract: Particular aspects provide bioresorbable and biocompatible compositions for bioengineering, restoring or regenerating tissue or bone, comprising a three-dimensional porous or non-porous scaffold material comprising a calcium phosphate-based ceramic having at least one dopant therein selected from metal ion or ion dopants and metal oxide dopants, wherein the composition is sufficiently biocompatible to provide for a cell or tissue scaffold, and resorbable at a controlled resorption rate for controlled strength loss, depending on dopant composition, under body, body fluid or simulated body fluid conditions. Preferably, the at least one dopant is selected from the group consisting of Zn2+, Mg2+, Si2+, Na+, K+, Sr2+, Cu2+, Fe3+/Fe2+, Ag+, Ti4+, CO32?, F?, MgO, ZnO, NaF, KF, FeO/Fe2O3, SrO, CuO, SiO2, TiO2, Ag2O and CaCO3, present in an amount between 0 and about 10 w %, from about 0.5 to about 5 w %, or from about 1 to about 3 w %, and methods of using same.Type: GrantFiled: April 25, 2007Date of Patent: May 12, 2015Assignee: Washington State UniversityInventors: Susmita Bose, Amit Bandyopadhyay
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Patent number: 9028859Abstract: Medical devices and coatings for medical devices are disclosed, including methods for forming the devices and coatings. The devices and coatings comprise a phase-separated block copolymer matrix and one or more active agents. The phase-separated block copolymer matrix can be used to modulate the release-rate of one or more active agents from the medical device.Type: GrantFiled: July 7, 2006Date of Patent: May 12, 2015Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Thierry Glauser
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Publication number: 20150125508Abstract: Disclosed are various bioactive grafts and/or biocompatible materials and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized. In another embodiment, an orthopedic implant includes an antibacterial polysaccharide. The implant may also include an osteostimulative agent.Type: ApplicationFiled: January 16, 2015Publication date: May 7, 2015Inventors: Amit Prakash GOVIL, Christian GAMBOA
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Patent number: 9023379Abstract: Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto compounds are described. Also described are the methods and compositions wherein the tissue is fixed using biodegradable crosslinkers. Methods and compositions for making radio-opaque tissue are also described. Methods and compositions to obtain a degradable implantable tissue-synthetic biodegradable polymer composite are also described. Compositions and methods of incorporating substantially water-insoluble bioactive compounds in the implantable tissue are also disclosed. The use of membrane-like implantable tissue to make an implantable drug delivery patch are also disclosed. Also described are the compositions and methods to obtain a coated implantable tissue. Medical applications implantable tissue such as heart valve bioprosthesis, vascular grafts, meniscus implant, drug delivery patch are also disclosed.Type: GrantFiled: February 8, 2013Date of Patent: May 5, 2015Assignee: Pathak Holdings LLCInventors: Chandrashekhar P. Pathak, Sanjay M. Thigle
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Patent number: 9017713Abstract: The present invention relates to magnetic carriers and medical preparations for controllable delivery and release of active substances. The carrier for active substances comprises material A, which is magnetically or electrically sensible, and material B capable of controlling the retention/release rate of the said active substance from the said carrier, the said retention/release rate being temperature dependent; wherein the material B is in thermal contact with material A, and wherein the material A has magnetocaloric or electrocaloric effect sufficient to substantially vary the said retention/release rate of the active substance from the carrier. The invention further provides methods for controllable delivery and release of active substances in a predetermined place and at a predetermined time, and methods of treatment using these carriers. Methods of production of magnetic carriers are also proposed.Type: GrantFiled: April 10, 2009Date of Patent: April 28, 2015Inventors: Aleksandr Mettalinovich Tishin, Juri Alekseevich Rochev, Aleksandr Vladimirovich Gorelov
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Patent number: 9017709Abstract: The present invention relates to an injectable composition which comprises polymeric, water-insoluble, non-biodegradable, anionic particles, these particles having an irregular shape and a biocompatible carrier with a lubricated surface, a method for preparing the same, a method for treating a tissue in a patient which comprises injecting into the tissue site the injectable composition as a permanent implant and the use of the injectable composition as a medicament, particularly for bulking a tissue site.Type: GrantFiled: August 11, 2005Date of Patent: April 28, 2015Assignee: Promedon S.A.Inventors: Osvaldo Nicolas Griguol, Dante Miguel Beltramo, Ismael Dario Bianco, Roxana Alasino
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Patent number: 9017715Abstract: Polymer and drug containing compositions and method of preparing such compositions are disclosed. The dispersed phase formulation has a polymer, a pharmaceutically or biologically active agent and a small fraction of low pKa acid additive. Stable, filter sterilizable, non-gelling solutions containing GnRH analogs at least at levels typically used in sustained release formulations and a method of increasing solubility of a high level of a GnRH analog or a freeze-dried antgonist of GnRH in a polymer containing solution are also disclosed. The amount of the acid additive in the polymer solution is such that it is sufficient to increase the solubility of the high level of the GnRH analog in the polymer solution without affecting the release characteristics of the microspheres prepared therefrom.Type: GrantFiled: November 5, 2012Date of Patent: April 28, 2015Assignee: Oakwood Laboratories, L.L.C.Inventors: Bagavathikanun C. Thanoo, James Murtagh, Gonto Johns
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Patent number: 9017714Abstract: A nerve regeneration-inducing tube is provided which is excellent in cell growth property, resistance to pressure, shape recovery property, and anti-kink property in a nerve regeneration-inducing tube where a collagen solution is applied on the outer surface of a tubular body woven with ultrafine fiber comprising biodegradable and bioabsorbable polymer while collagen is filled in the inner area of the tubular body. The nerve regeneration-inducing tube has a degradation speed which is adjusted so as to make it suitable for the connection of nerve gaps of more than 40 mm. The nerve regeneration-inducing tube includes collagen coated on the outer surface of a tubular body woven with fiber bundles where plural ultrafine fibers comprising a biodegradable and bioabsorbable polymer are bundled. The tubular body mostly comprises a first polymer which is biodegradable and bioabsorbable and a second polymer which has higher biodegradability and bioabsorbability than those of the first polymer.Type: GrantFiled: December 25, 2008Date of Patent: April 28, 2015Assignee: Toyo Boseki Kabushiki KaishaInventors: Fumihiko Kajii, Hidenori Tanaka, Susumu Kashiwabara, Yuta Kawakatsu
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Publication number: 20150112424Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.Type: ApplicationFiled: August 29, 2014Publication date: April 23, 2015Inventors: James DeYoung, Doug Taylor, Jim McClain, Clint Smoke, Mike Cole
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Patent number: 9012594Abstract: A method of synthesizing a biocompatible hydrogel by covalently cross-linking an effective amount of a first macromonomer including a cyclic thioester group with an effective amount of a second macromonomer including a terminal cysteine group is disclosed. In addition, the synthesis and use of the following specific cyclic thioester macromonomer that can be used in the method, as well as specific hydrogels made using this macromonomer are disclosed. The disclosed method produces a biocompatible hydrogel, while producing substantially no toxic free thiol by-product. Accordingly, the method can be used in making biomedical products, such as sutures and tissue replacement biomaterials, and for encapsulating therapeutic cells and pharmaceuticals.Type: GrantFiled: April 20, 2011Date of Patent: April 21, 2015Assignee: Northwestern UniversityInventors: Phillip B. Messersmith, Jing Su, Bi-Huang Hu
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Patent number: 9011411Abstract: Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or without a drug or combination of drugs incorporated therein, or a drug solution without a solidifiable matrix. The treatment solution is coated onto at least a portion of the internal cavity, and acts as a slow-release drug delivery system.Type: GrantFiled: December 23, 2012Date of Patent: April 21, 2015Assignee: Theracoat Ltd.Inventors: Asher Holzer, Dorit Daniel, Eran Hirszowicz
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Publication number: 20150104490Abstract: A growth-inhibited hydroxyapatite is contained in agglomerates of prestructured collagen templates, wherein the prestructured collagen templates are denatured or broken up so that fibrillogenesis of the prestructured collagen templates is inhibited. Epitactic hydroxyapatite crystallites with a crystallite size below a critical nucleus radius are formed on the prestructured collagen templates.Type: ApplicationFiled: December 19, 2014Publication date: April 16, 2015Inventors: Sascha Heinemann, Christiane Heinemann, Hartmut Worch, Thomas Hanke, Wolfgang Pompe
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Publication number: 20150098899Abstract: Timed-bioresorbable particulates, particularly microspheres or fibers, may be used as a vehicle for delivery of radioisotopes, such as Y-90 and Pd-103 for localized radiotherapy, or as an embolic device. These particulates may also be embedded in polymers, or dispersed in injectable gels or other injectable media for the treatment of various cancers. The benefit of bioresorption, the ability to control the ratio of radioisotopes in the particulate, especially the gamma and beta ratios such as In-111/Y-90 ratio in a particulate, and the benefit of non-conductive implants are disclosed.Type: ApplicationFiled: March 24, 2014Publication date: April 9, 2015Applicant: XL Sci-Tech, Inc.Inventors: Yongren Benjamin PENG, Xingye Cherry Lei
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Patent number: 8999368Abstract: The implant design is a drug loaded polymer device, such as a rod, designed to control the release of a biologically active agent, such as clonidine or its derivatives, such as clonidine HCl for a prolonged period of time, such as 2 months, 3 months, 4 months, and even 4.5 months. The polymer is preferably a biodegradable polymer, such as poly(lactide-co-glycolide) or polylactic acid/polylactide. The challenge in using the HCl salt forms of drugs such as clonidine, is controlling the release of the highly water soluble drug for up to 4.5 months. It has been found that by controlling the particle size distribution of the drug powder, the drug distribution within the polymer matrix is more uniform and can be controlled. Therefore, the large aggregates, which cause rapid drug release can be eliminated.Type: GrantFiled: July 3, 2013Date of Patent: April 7, 2015Assignee: Warsaw Orthopedic, Inc.Inventors: Phillip E. McDonald, Kathy L. Remsen
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Patent number: 8999369Abstract: Methods and devices relating to polymer-bioceramic composite implantable medical devices, such as stents are disclosed. A suspension solution is formed including a fluid, a biodegradable polymer, and bioceramic particles. The biodegradable polymer and particles are precipitated from the suspension to form a mixture. A composite is formed by combining the mixture with another polymer and a scaffolding is formed from the composite.Type: GrantFiled: August 7, 2013Date of Patent: April 7, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: David C. Gale, Yunbing Wang, Syed Faiyaz Ahmed Hossainy, Bin Huang, Garth L. Wilkes, Vincent J. Gueriguian
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Patent number: 8999377Abstract: Biocompatible foams having excellent physical and chemical properties are described. The biocompatible foams can be formed in situ or applied as a pre-formed foam for the treatment of tissue. The invention provides biocompatible degradable foams formed with a poly-?(1?4)glucopyranose macromer. The invention also provides biostable foams formed with a poly(alkylene oxide) macromer.Type: GrantFiled: September 19, 2008Date of Patent: April 7, 2015Assignee: Surmodics, Inc.Inventors: Emily R. Rolfes, Pamela J. Reed
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Patent number: 8992966Abstract: An artificial bone capable of being absorbed and replaced by an autogenous bone, which comprises a cylindrical body comprising at least an apatite/collagen composite layer and a collagen layer.Type: GrantFiled: December 24, 2009Date of Patent: March 31, 2015Assignee: Hoya CorporationInventor: Daisuke Shoji
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Patent number: 8992512Abstract: According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes the following: (a) one or more unsaturated hydrocarbon monomer species and (b) one or more heteroatom-containing monomer species.Type: GrantFiled: December 8, 2011Date of Patent: March 31, 2015Assignee: Boston Scientific Scimed, Inc.Inventors: Robert E. Richard, Marlene C. Schwarz, Rudolf Faust
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Patent number: 8992968Abstract: A fiber-reinforced composite ring for the controlled release of at least one bioactive agent includes a biocompatible matrix reinforced with absorbable/biodegradable fibers capable of providing the mechanical properties needed for inserting and maintaining the ring in a body cavity for a desired period of time. Such ring system as can be used for the intravaginal, intraperitoneal, and subcutaneous delivery of at least one bioactive agent, including those used as contraceptives, antimicrobial agents, and/or antiviral agents, as well as those for the treatment of cancer.Type: GrantFiled: February 20, 2013Date of Patent: March 31, 2015Assignee: Poly-Med, Inc.Inventor: Shalaby W. Shalaby
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Patent number: 8992967Abstract: The present invention is directed to a novel poly(diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material.Type: GrantFiled: October 24, 2013Date of Patent: March 31, 2015Assignee: Northwestern UniversityInventors: Guillermo Ameer, Hongjin Qiu, Jian Yang
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Patent number: 8992965Abstract: An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.Type: GrantFiled: November 1, 2006Date of Patent: March 31, 2015Assignee: Warsaw Orthopedic, Inc.Inventor: Keyvan Behnam
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Publication number: 20150086605Abstract: The technology described herein is directed to compositions comprising at least a first porous biomaterial layer and a second impermeable biomaterial layer and methods relating thereto. In some embodiments, the compositions and methods described herein relate to wound healing, e.g. repair of wounds and/or tissue defects.Type: ApplicationFiled: February 5, 2013Publication date: March 26, 2015Inventors: Joshua R. Mauney, Carlos R. Estrada, David L. Kaplan, Eun Seok Gil
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Publication number: 20150086604Abstract: Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness.Type: ApplicationFiled: September 23, 2013Publication date: March 26, 2015Inventors: Fatima Buevich, Frank Do, William McJames, Satish Pulapura, William Edelman, Arikha Moses, Mason Diamond, Shari Timothy
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Publication number: 20150086607Abstract: A synthetic construct suitable for implantation into a biological organism that includes at least one polymer scaffold; wherein the at least one polymer scaffold includes at least one layer of polymer fibers that have been deposited by electrospinning; wherein the orientation of the fibers in the at least one polymer scaffold relative to one another is generally parallel, random, or both; and wherein the at least one polymer scaffold has been adapted to function as at least one of a substantially two-dimensional implantable structure and a substantially three-dimensional implantable tubular structure.Type: ApplicationFiled: September 25, 2014Publication date: March 26, 2015Inventors: Jed K. JOHNSON, Ross KAYUHA
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Publication number: 20150086606Abstract: A bioresorbable and bioactive three-dimensional porous material made from bioresorbable polymers that can be combined with bioactive ceramics, producing a three-dimensional structure of interlinked pores containing additives capable of allowing the regeneration and formation of tissues, and a method for the production thereof is described.Type: ApplicationFiled: September 28, 2012Publication date: March 26, 2015Inventors: Walter Israel Rojas Cabrera, Karina Nakajima, Luana Bendo
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Patent number: 8986728Abstract: The present invention provides an implantable device having a biosoluble coating or a biosoluble body structure comprising a polyelectrolyte and a counterion and the methods of making and using the same.Type: GrantFiled: July 9, 2012Date of Patent: March 24, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: Syed F. A. Hossainy, Mikael O. Trollsas, Lothar W. Kleiner
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Patent number: 8986724Abstract: Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.Type: GrantFiled: June 21, 2013Date of Patent: March 24, 2015Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Thierry Glauser, Stephen D. Pacetti, Paul M. Consigny
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Publication number: 20150079148Abstract: In described embodiments, the present invention includes a magnesium-based composite material formed from a plurality of ?-phase magnesium grains; and a ?-alloy phase comprising magnesium and nano-diamond and/or and phosphate containing nanoparticles, the ?-alloy phase surrounding each of the plurality of magnesium grains. A method of manufacturing a composite material is also disclosed.Type: ApplicationFiled: April 18, 2013Publication date: March 19, 2015Inventors: Gongyao Zhou, Haibo Gong, Donggang Yao
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Publication number: 20150080855Abstract: Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.Type: ApplicationFiled: September 17, 2013Publication date: March 19, 2015Applicant: DTherapeutics, LLCInventors: Ghassan S. Kassab, Jose A. Navia, SR.
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Patent number: 8980300Abstract: A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.Type: GrantFiled: May 29, 2009Date of Patent: March 17, 2015Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Stephen Dirk Pacetti, Yiwen Tang, Syed Faiyaz Ahmed Hossainy
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Patent number: 8980301Abstract: A blood product (10), a method for preparing the blood product, a blood product obtainable by the method and a blood product preparing container means. The blood product comprises components from whole blood, especially fibrin, thrombocytes and leukocytes. The blood product (10) comprises a first layer (21), a second layer (22) and a third layer (23). The second layer (22) is adjacent to the first layer (21) and the third layer (23). The first layer (21) defines a first outer surface (24) of the blood product (10) and the third layer (23) defining a second outer surface (25) of the blood product (10). The first layer (21) comprises a majority of fibrin, the second layer (22) comprises a majority of thrombocytes and the third layer (23) comprises a majority of leukocytes.Type: GrantFiled: August 24, 2009Date of Patent: March 17, 2015Assignee: Reapplix APSInventors: Rasmus Lundquist, Niels Erik Holm
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Patent number: 8980302Abstract: Surgical implants of the present disclosed include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct contact with a mesh. The first therapeutic agent may be released at a first rate and the second therapeutic agent may be released at a second rate.Type: GrantFiled: May 12, 2014Date of Patent: March 17, 2015Assignee: Covidien LPInventors: Joshua Stopek, Amin Elachchabi, Daniel Broom, Garrett Ebersole
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Patent number: 8980317Abstract: The present invention is directed to a drug depot useful for reducing, preventing or treating an infection in a patient in need of such treatment. The drug depot includes a polymer and a therapeutically effective amount of a local anesthetic or pharmaceutically acceptable salt thereof. The drug depot is administered at a site to reduce, prevent or treat an infection. The drug depot is capable of releasing (i) a bolus dose of the local anesthetic or pharmaceutically acceptable salt thereof at the site and (ii) a sustained release dose of an effective amount of the local anesthetic or pharmaceutically acceptable salt thereof over a period of at least 4 days at the site.Type: GrantFiled: November 9, 2009Date of Patent: March 17, 2015Assignee: Warsaw Orthopedic, Inc.Inventor: Vanja Margareta King
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Patent number: 8975231Abstract: A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.Type: GrantFiled: June 1, 2012Date of Patent: March 10, 2015Assignees: The Regents of the University of California, The United States of America represented by the Department of Veterans AffairsInventors: Samuel S. Murray, Elsa J. Brochmann-Murray, Jeffrey Wang, Keyvan Behnam
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Publication number: 20150064229Abstract: Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.Type: ApplicationFiled: November 7, 2014Publication date: March 5, 2015Inventors: Charanpreet S. BAGGA, Steve B. JUNG, Hyun W. BAE
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Patent number: 8968417Abstract: Bioactive implant for myocardial regeneration and ventricular chamber support including an elastomeric microporous membrane. The elastomeric microporous membrane being at least one non-degradable polymer and at least one partially degradable polymer. The non-degradable polymer is selected from polyethylacrylate and polyethylacrylate copolymerized with a hydroxyethylacrylate comonomer. The partially degradable polymer is selected from caprolactone 2-(methacryloyloxy)ethyl ester and caprolactone 2-(methacryloyloxy)ethyl ester copolymerized with ethylacrylate. The elastomeric microporous membrane further includes a nanofiber hydrogel, and cells. The bioactive implant, having one or two helical loops, contributes to the restauration of the heart conical shape.Type: GrantFiled: October 25, 2012Date of Patent: March 3, 2015Assignees: Institut Quimic de Sarria, Universitad Politecnica de Valencia, Fundacio Institut d'Investigacio Sanitaria Germans Trias Pujol, Association Cardio-MondeInventors: Juan Carlos Chachques, Antonio Bayes Genis, Manuel Monleon Pradas, Carlos Eduardo Semino, Nicole Zur Nieden, Philippe Jenny
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Patent number: 8968767Abstract: Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least analgesic and/or at least one anti-inflammatory agent at or near a target site, one can reduce, prevent or treat inflammation and pain.Type: GrantFiled: May 10, 2013Date of Patent: March 3, 2015Assignee: Warsaw Orthopedic, Inc.Inventor: William F. McKay
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Patent number: 8968392Abstract: A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.Type: GrantFiled: July 30, 2012Date of Patent: March 3, 2015Assignees: Japan Stent Technology Co., Ltd., Tokai University Educational System, Toyo Advanced Technologies Co., Ltd., Hiroo IwataInventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
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Patent number: 8968766Abstract: Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.Type: GrantFiled: February 26, 2013Date of Patent: March 3, 2015Assignee: Allergan, Inc.Inventors: Patrick M. Hughes, Thomas C. Malone, Gerald W. DeVries, Jeffrey L. Edelman, Joan-En Lin, Jane-Guo Shiah, Thierry Nivaggioli
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Patent number: 8968763Abstract: Disclosed herein are implantable medical devices comprising controlled release biodegradable block copolymers or coated with controlled release block copolymers and at least one drug releasable from the block copolymer. The controlled release block copolymers comprise least two blocks selected from the group consisting of polyesters, polyethers, and polyurethanes.Type: GrantFiled: February 19, 2010Date of Patent: March 3, 2015Assignee: Medtronic Vascular, Inc.Inventors: Ya Guo, Peiwen Cheng
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Patent number: 8968761Abstract: Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.Type: GrantFiled: November 20, 2012Date of Patent: March 3, 2015Assignee: ACell, Inc.Inventors: Rodney W. Bosley, Jr., Clay Fette, Robert S. Tullius
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Patent number: 8968782Abstract: The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.Type: GrantFiled: June 28, 2007Date of Patent: March 3, 2015Assignee: SurModics, Inc.Inventors: Ralph A. Chappa, Robert W. Hergenrother, Paula Bushendorf, Joram Slager
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Patent number: 8968765Abstract: The present disclosure provides a brush polymer, including: a linear polymer main chain; and brush structural side chains, including: a hydrophobic molecular branch, and a hydrophilic molecular branch and/or an anti-biofilm/or an anti-microbial molecular branch, wherein the linear polymer main chain is conjugated to the side chains by covalent bonds formed between a hydroxyl group and a reactive functional group, wherein the reactive functional group includes: isocyanate, carboxyl, or epoxy. The present disclosure also provides a medical application of the brush polymer.Type: GrantFiled: August 27, 2012Date of Patent: March 3, 2015Assignee: Industrial Technology Research InstituteInventors: Jui-Hsiang Chen, Jean-Dean Yang, Yu-Hua Chen, Ting-Yu Shih, Chia-wei Hong, Chao-Chen Tien