Surgical Implant Or Material Patents (Class 424/423)
  • Patent number: 11446297
    Abstract: The present disclosure generally relates to methods of treating hemolytic diseases such as sickle cell anemia using kinase inhibitors, for example, compounds that inhibit the spleen tyrosine kinase (SYK). In some embodiments a method is presented to prevent thrombosis in blood vessels of patients with a hemolytic disease comprising the step of: administrating to a patient having at least one hemolytic disease a therapeutically effective amount of at least one SYK inhibitor. In some embodiments the method includes repeatedly administering the SYK kinase inhibitor to a patient.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: September 20, 2022
    Assignees: Purdue Research Foundation
    Inventors: Phillip S. Low, Francesco Turrini, Antonella Pantaleo
  • Patent number: 11439587
    Abstract: Provided herein injectable implant compositions useful for acceleration of bone fracture healing, treatment of dental or oral pathologies, and controlled drug delivery.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: September 13, 2022
    Inventors: Michael Friedman, David Kirmayer, Rami Mosheiff, Jacob Rachmilewitz, Amal Khoury, Doron Steinberg
  • Patent number: 11440874
    Abstract: Ketamine derivatives and pharmaceutical compositions thereof are disclosed. When administered orally the ketamine derivatives provide increased bioavailability of ketamine in the systemic circulation. The ketamine derivatives can be used to treat neurological diseases, psychological diseases and pain.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: September 13, 2022
    Assignee: XWPHARMA LTD.
    Inventors: Jia-Ning Xiang, Xuesong Xu, Hao-Wei Shih, Wai-Si Eng
  • Patent number: 11433163
    Abstract: A composition including, (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid, is provided. Moreover, a kit which includes: a syringe, a mineral particle covered with endothelial cells and mesenchymal cells organized in 2 or more cell layers attached to the mineral particle, and hyaluronic acid, is also provided. Last, a method for filling a gap in a bone of a subject in need thereof, including contacting the gap with a composition of: (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid is provided.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: September 6, 2022
    Inventor: Shai Meretzki
  • Patent number: 11433159
    Abstract: Implantable bone compositions are provided. The implantable compositions comprise hydratable bone putties. The hydratable bone putties comprise porous ceramic granules having an average diameter from about 50 ?m to 800 ?m. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The implantable bone compositions further include collagen carriers. In some embodiments, the hydratable bone putty can be hydrated to form a non-settable flowable cohesive cement or gel. Methods of making and using the implantable compositions are also provided.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: September 6, 2022
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Ian Dunkley, Gretchen Selders
  • Patent number: 11433116
    Abstract: The present invention describes methods of treating, preventing, reducing the likelihood of having, reducing the severity of and/or slowing the progression of a medical condition related to ischemia/reperfusion in a subject using GJA1-20k as a therapeutic agent. The invention further provides a method of protecting a cell from metabolic stress, using GJA1-20k. The invention also provides for a composition and/or gene expression vector comprising GJA1-20k.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: September 6, 2022
    Assignee: Cedars-Sinai Medical Center
    Inventors: Robin Shaw, TingTing Hong, Ying Fu, Shaohua Xiao, Wassim Basheer
  • Patent number: 11434460
    Abstract: A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: September 6, 2022
    Inventors: Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Lori E Romeo
  • Patent number: 11419745
    Abstract: An apparatus for treating obesity comprises a volume filling device formed by at least two segments and is provided and following implantation, the device is placed resting against the stomach wall of the patient to reduce the inner volume of the stomach, thereby affecting the patient's appetite.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: August 23, 2022
    Inventor: Peter Forsell
  • Patent number: 11407168
    Abstract: Methods to fabricate objects by 3D printing of poly-4-hydroxybutyrate (P4HB) and copolymers thereof have been developed. In one method, these objects are produced by continuous fused filament fabrication using an apparatus and conditions that overcome the problems of poor feeding of the filament resulting from the low softening temperature of the filament and heat creep along the fed filament. Methods using an apparatus including a heat sink, a melt tube, a heating block and nozzle, and a transition zone between the heat sink and heating block, with the melt tube extending through the heat sink, transition zone, and heat block to the nozzle are disclosed. 3D objects are also printed by fused pellet deposition (FPD), melt extrusion deposition (MED), selective laser melting (SLM), printing of slurries and solutions using a coagulation bath, and printing using a binding solution and polymer granules.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: August 9, 2022
    Assignee: Tepha, Inc.
    Inventors: Skander Limem, Reshad Bin Harun, Matthew Dubois, David P. Martin, Said Rizk
  • Patent number: 11406533
    Abstract: Glaucoma treatment devices are disclosed. In various example, the glaucoma treatment devices include multiple microporous layers arranged together to form a microporous body configured to help facilitate evacuation of fluid from a fluid-filled body cavity, and reabsorption of the evacuated aqueous humor by the body through tissue surrounding the glaucoma treatment device. In some examples, the glaucoma treatment device includes one or more portions configured to resist cellular ingrowth, and one or more portions configured to permit cellular ingrowth.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: August 9, 2022
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Peter J. Roeber, Jeffrey C. Towler
  • Patent number: 11407855
    Abstract: We have developed a ring opening polymerization method in an aqueous dispersion for the formation of latex. By encapsulating a catalyst in micelles dispersed in water, a seeded catalytic polymerization of various monomers in water was successfully performed. An amphiphilic molecule was used to form a micelle with a hydrophobic core in water. The catalyst that was encapsulated within this structure and the formed microcapsules were used as microreactors for the formation of biodegradable elastomers.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: August 9, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Damien S. Guironnet, Danielle Harrier, Paul Kenis
  • Patent number: 11401639
    Abstract: A non-woven chopped fiber mat includes a mixture of glass fibers and synthetic fibers. The non-woven mat is formed using a binder composition that includes a binder resin, a coupling agent, and a corrosion inhibitor. The non-woven mat is non-corrosive and resistant to volatile unsaturated monomers such as styrene, but still remains fully compatible with solvent-containing polyester resins, such that it can be used in various pultruded products.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: August 2, 2022
    Assignee: Owens Corning Intellectual Capital, LLC
    Inventors: Jianhui Wu, Kevin Spoo, Jeff Pessell
  • Patent number: 11401627
    Abstract: Disclosed is a method for preparing a quantum rod/polymer fiber membrane by using electrospinning technique. The method comprises the following steps: (1) preparing a quantum rod solution; (2) preparing a polymer solution, and adding the quantum rod solution obtained in step (1) into the polymer solution so as to form an electrospinning precursor solution with a volume concentration of the quantum rods of 5%-80%; and (3) adding the electrospinning precursor solution into an electrospinning device, regulating the voltage of a generator and the receiving distance, and then performing electrospinning to prepare the quantum rod/polymer fiber membrane. By adjusting the concentration of the quantum rod solution and parameters in the electrospinning process, the method realizes directional arrangements of the quantum rods in the electrospinning process, thereby obtaining the quantum rod/polymer fiber membrane with high degree of polarization performance.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: August 2, 2022
    Inventors: Kai Wang, Ziming Zhou, Jing Qin, Zuoliang Wen, Shang Li, Junjie Hao, Wei Chen, Xiaowei Sun
  • Patent number: 11389558
    Abstract: A wound dressing including a hydropolymer matrix crosslinked with genipin and a plurality of thymol nanoparticles loaded into the hydropolymer matrix. The plurality of thymol nanoparticles has a concentration between 0.01 wt. % and 1 wt. % of dry weight of the wound dressing. The hydropolymer matrix includes gelatin, chitosan, polyvinylpyrrolidone (PVP), and carboxymethyl cellulose (CMC).
    Type: Grant
    Filed: September 12, 2020
    Date of Patent: July 19, 2022
    Inventor: Amin Mohammadi Purfard
  • Patent number: 11389564
    Abstract: The present invention relates to a method for constructing a whitlockite coating on a surface of a calcium phosphate-based bioceramic substrate and a resulting coating, wherein the preparation method includes the following steps of: preparing pure calcium phosphate-based bioceramic powder firstly, then pre-firing, shaping and calcining the pure calcium phosphate-based bioceramic powder to obtain a calcium phosphate-based bioceramic substrate, placing the substrate in a solution containing Mg2+, then transferring the substrate to a high-temperature high-pressure reaction kettle for a hydrothermal reaction, and then cleaning and drying the sample to obtain a whitlockite coating.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: July 19, 2022
    Inventors: Yingjun Wang, Xiaoheng Guo, Naru Zhao
  • Patent number: 11357885
    Abstract: A system related to the reparation of damaged veins along with the suspension of venous stasis progression by minimizing the leak reflux flow and the protection of the valve functions of the vena saphena magna, parva, perforator veins by means of exovascular or external filling agent injection in the treatment of venous stasis (which is also called varicose vein or varicose treatment).
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: June 14, 2022
    Inventor: Rasit Dinc
  • Patent number: 11345894
    Abstract: The present invention provides methods for cellular seeding onto three-dimensional fibroblast constructs, three-dimensional fibroblast constructs seeded with muscle cells, and uses therefore.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: May 31, 2022
    Inventors: Jordan Lancaster, Steve Goldman
  • Patent number: 11346820
    Abstract: Presented are improved and more sensitive methods for measuring levels of phytoestrogens in a biological sample, and specifically in a human urine sample, employing a High Pressure Liquid Chromatography method, coupled with a photodiode array analysis detection system. Calibration curve preparation for each of a panel of phytoestrogen analytes, including daidzein, equol and genistein, are provided employing techniques that demonstrate greater accuracy and sensitivity of sample level measurement. Clinically applicable techniques suitable for large population scale screening, diet and gut microflora characterization and disease analysis and correlation in human populations, such as in at risk breast cancer populations, through monitoring of phytoestrogen levels, is disclosed.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: May 31, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventor: Maria Teresa Aguirre
  • Patent number: 11344573
    Abstract: The present invention generally relates to the treatment of gynoid lipodystrophy, and more specifically to the use of calcium (hydroxy)phosphate particles in combination with at least one compound capable of reducing local subcutaneous fat in the treatment of gynoid lipodystrophy.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: May 31, 2022
    Inventors: Harry Frank Abst, Rainer Pooth, Martina Kerscher, Thomas Hengl, Birgit Blessmann-Gurk, Sabine Otto
  • Patent number: 11337960
    Abstract: The disclosure provides thiol-containing alkyl fatty acid compound formulations for intravenous, parenteral or oral administration. The compositions of the present technology have optimal controlled bioavailability and are useful for treating metabolic dysfunctions such as pre-diabetes, Metabolic Syndrome and diabetes. Also provided are methods of treatment comprising the daily administration of the disclosed thiol-containing alkyl fatty acid formulations.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: May 24, 2022
    Assignee: Pre-D Partners LLC
    Inventor: Robert Shorr
  • Patent number: 11337863
    Abstract: A nitric oxide gas-releasing conduit configured for surgical implantation through a patient's tympanic membrane. The nitric oxide gas-releasing conduit comprises a gas-permeable cured resin material configured for releasably sequestering therein gas. The gas-permeable cured resin material is charged with nitric oxide gas. The nitric oxide gas-releasing conduit may be optionally coated with an antimicrobial gas-releasing composition. The gas-releasing coating composition may be configured to release nitric oxide.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: May 24, 2022
    Assignee: ENOX (ISRAEL) LTD.
    Inventors: Yossef Av-Gay, David Greenberg
  • Patent number: 11331408
    Abstract: Disclosed are hydrogels polymerized with a biofunctional moiety, biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) biofunctional end groups. The hydrophobicity of the various structural elements are chosen to reduce tissue adhesion and enhance the biofunctional aspect of the end groups. The morphology of these polymers are typically of high molecular weight and have shape to encourage entanglement. Useful structures include branching chains, comb or brush, and dendritic morphologies.
    Type: Grant
    Filed: July 29, 2018
    Date of Patent: May 17, 2022
    Assignee: BVW Holding AG
    Inventors: Lukas Bluecher, Michael Milbocker
  • Patent number: 11331396
    Abstract: Radiation therapy or radiotherapy (RT) is a powerful treatment where precision and accuracy is crucial. Image Guided Radiotherapy (IGRT) facilitates more accurate position verification, correcting for anatomic changes related to internal organ movement. IGRT thereby helps reduce toxicity of radiotherapy and increases relapse-free survival. An inter-correlation point with a fixed position and volume (a marker) can be applied to indicate the point of treatment clearly in both imaging modalities and to localize and track tumors in real time. In this study, we present the development of a marker based on lactose octaacetate:octapropionate 1:1 containing 3 mM PLA-DTPA(Gd), 40% triglyceride, 5% propylene carbonate and 10% XSAIB (sucrose based CT-contrast agent). The injectable marker had high CT contrast (>1000 HU) and displayed clearly visible, stable T1 contrast enhancement (T1˜900 ms) in the rim over at least 3 weeks with clinically observable resolution.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: May 17, 2022
    Inventors: Thomas Andresen, Rasmus Irming Jølck, Linda Maria Bruun
  • Patent number: 11326262
    Abstract: A hydrogel is formed by a reaction which is induced, in an electrolytic solution, by an electrode product electrochemically generated by electrodes installed in the electrolytic solution. An apparatus including an electrolytic tank with a bottom surface on which a two-dimensional array of working electrodes is provided and a counter electrode installed in the electrolytic tank is prepared. An electrolytic solution containing a dissolved substance that causes electrolytic deposition of a hydrogel is housed in the electrolytic tank. By applying a predetermined voltage to one or more selected working electrodes of the two-dimensional array, a hydrogel with a two-dimensional pattern corresponding to the arrangement of the selected working electrodes is formed.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: May 10, 2022
    Inventors: Kosuke Ino, Tomokazu Matsue, Hitoshi Shiku, Mayuko Terauchi, Noriko Taira, Ryota Kunikata, Atsushi Suda
  • Patent number: 11320355
    Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: May 3, 2022
    Assignee: Labrador Diagnostics LLC
    Inventors: Mark Dayel, Samartha Anekal, Elizabeth A. Holmes
  • Patent number: 11311645
    Abstract: A pulverulent semisynthetic material, derived from a natural marine biomaterial, namely the aragonitic inner layer of the shell of bivalve molluscs selected from Pinctadines, notably Pinctada maxima, margaritifera, and Tridacnes, notably Tridacna gigas, maxima, derasa, tevaroa, squamosa, crocea, Hippopus hippopus, Hippopus porcelanus, in pulverulent form, with the addition of insoluble and soluble biopolymers and calcium carbonate transformed by carbonation.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: April 26, 2022
    Assignee: MBP (MAURITIUS) LTD
    Inventors: Georges Camprasse, Serge Camprasse
  • Patent number: 11311368
    Abstract: The present disclosure relates to a device for printing a lumen tissue construct, a method for using the same, and a 3D bioprinter. The device includes a spray head assembly for printing a biological construct; and a bioprinting platform for supporting a lumen tissue, and for carrying a biological construct printed by the spray head assembly, and for applying the biological construct to an inner surface of the lumen tissue. The device for printing a lumen tissue construct of the present disclosure provides the spray head assembly and the bioprinting platform, and the spray head assembly applies the biological construct onto the inner surface of the lumen tissue by the bioprinting platform, to avoid such problems as recurrence of thrombus and restenosis of a lumen after the lumen tissue has been implanted for a long time, thereby improving the biological reliability of the lumen tissue.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: April 26, 2022
    Assignee: Revotek Co., Ltd
    Inventors: Yijun Li, Junxuan He, Zhi Jiang, Xiaolin Hu, Leqing Zhang, Deming Wang
  • Patent number: 11305038
    Abstract: The present application relates to biomimetic three-dimensional (3D) scaffolds, constructs and methods of making the same. The three-dimensional scaffold can include a sacrificial internal cast and a durable external scaffold material, wherein the durable external scaffold material comprises a biocompatible material which completely surrounds the sacrificial internal cast and wherein the sacrificial internal cast be removed to yield a branching 3D network of hollow, vessel-like tubes that substantially mimics a native tissue or organ.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: April 19, 2022
    Assignee: Wake Forest University Health Sciences
    Inventors: James Yoo, In Kap Ko, Jennifer Huling, Anthony Atala
  • Patent number: 11298440
    Abstract: The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: April 12, 2022
    Assignee: BVW Holding AG
    Inventors: Lukas Bluecher, Michael Milbocker
  • Patent number: 11291539
    Abstract: Implants with fillable reservoirs have been developed that are suitable for rhinoplasty, breast reconstruction, ear reconstruction, and replacement, reconstruction or repair of other soft tissues. The implants can be filled with graft material prior to implantation. The implants are preferably made from resorbable polymers, can be tailored to provide different geometries, mechanical properties and resorption rates in order to provide more consistent surgical outcomes. The implants preferably have an interconnected network of unit cells with microporous outer layers and optionally some or all of the unit cells having at least one macropore in their outer layers. The implants can be loaded by injection with microfat, collagen, DCF, cells, bioactive agents, and other augmentation materials, prior to implantation.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: April 5, 2022
    Assignee: Tepha, Inc.
    Inventors: Skander Limem, Fabio Felix, Said Rizk, David P. Martin, Simon F. Williams
  • Patent number: 11285115
    Abstract: Compositions comprising self-assembled hydrogel particles formed of short peptides which comprise one or more aromatic amino acid residue(s) in an inverted emulsion are disclosed. Such hydrogel particles which encapsulate an active agent and uses thereof in therapeutic and diagnostic applications are also disclosed.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: March 29, 2022
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Rafael Ischakov, Ludmila Buzhansky, Lihi Adler-Abramovich, Ehud Gazit
  • Patent number: 11285177
    Abstract: Allograft biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting cartilage, tissue, bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. For example, the allograft may include viable cells, for example, which were native to intervertebral discs and/or umbilical cords that the allograft was derived from.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: March 29, 2022
    Assignee: Globus Medical, Inc.
    Inventors: David C. Paul, Archana Bhat, Breanna Seiber
  • Patent number: 11278648
    Abstract: A drug delivery balloon (10) has a drug thereon in the form of crystalline particles (12), the drug having a predetermined size distribution. Optionally marker particles (14, 16) are also provided. A texturized coating (18), a cap layer (20) and/or other methods may be used to increase particle loading capacity of the balloon.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: March 22, 2022
    Inventors: Aiden Flanagan, Jan Weber, John Clarke
  • Patent number: 11278647
    Abstract: Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including an acrylic acid polymer, an acrylamide copolymer comprising at least one photoreactive group, and a cross-linking agent comprising at least two photoreactive groups. The coating can be used on a catheter surface to facilitate its movement in the body.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: March 22, 2022
    Assignee: Surmodics, Inc.
    Inventor: Mike Militello
  • Patent number: 11266827
    Abstract: This invention addresses the need for efficient dry skin electrodes. Robust, flexible Mixed Ionic Electronic Conductor (MIEC) electrodes were prepared by an aqueous solution route resulting in electrically conductive networks of carbon nanotubes (CNTs) and ionically conductive elastic matrix. The flexible electrode was characterized in terms of conductivity, ionic charge transfer resistance, and water uptake. The flexible electrode maintained low resistance even after multiple cycles of 50% extension and contraction.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: March 8, 2022
    Assignee: Battelle Memorial Institute
    Inventors: Amy M. Heintz, Krenar Shqau, Ramanathan Lalgudi, Katherine M Palmer
  • Patent number: 11267972
    Abstract: In general, the present invention is directed to materials that when in use resist fouling on their surfaces. Such materials may be used in the construction of various process equipment having surfaces exposed to a given fluid that contains a foulant or chemical substance that may deposit on, or adhere to, the surface and thereafter continue to grow on the surface resulting in deteriorated performance of the equipment and process. The materials are specifically selected using a method that takes into account the dielectric spectra of the fluid to which the surface is exposed and the surface itself. It has been unexpectedly found that if the dielectric spectra of the surface and the fluid are matched to within relative agreement, there should be no adhesion of the foulant on the surface. In some embodiments, the dielectric spectra to be matched include the intrinsic indexes of refraction.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: March 8, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael P. Short, Max B. Carlson
  • Patent number: 11266766
    Abstract: Engineered human tissue seed constructs are provided that are suitable for implantation in subjects. Methods of making and using the engineered tissue seed constructs are provided.
    Type: Grant
    Filed: March 26, 2021
    Date of Patent: March 8, 2022
    Assignees: Massachusetts Institute of Technology, Trustees of Boston University
    Inventors: Sangeeta N. Bhatia, Kelly R. Stevens, Christopher S. Chen
  • Patent number: 11266764
    Abstract: The invention relates to methods for producing a polymeric scaffold for use in tissue engineering applications or soft tissue surgery, as well as to the produced scaffolds and an associated kit. The method features a first fast drying step of applying a mechanical compression on a polymeric gel layer and a second slow drying step of the gel up to reach a polymer mass fraction of at least 60% w/w in the final scaffold. The method allows the production of scaffolds with high regeneration and healing properties of a grafted tissue via host cell invasion and colonization, and a good suturability. These goals are achieved through the formation within the scaffold of a non-uniform architecture creating softer and stiffer areas, which is maintained even upon re-swelling of the scaffold upon hydration of the final dried product.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: March 8, 2022
    Assignee: Regenosca SA
    Inventors: Peter Frey, Jeffrey A. Hubbell, Hans M. Larsson, Elif Vardar, Eva-Maria Balet, Ganesh Vythilingam, Kalitha Pinnagoda
  • Patent number: 11267965
    Abstract: Crosslinked biodegradable block polyurethane copolymers prepared from a plurality of biodegradable polymers or oligomers linked together via urethane bonds and crosslinked via a citrate ester are disclosed. Such copolymers can include folic acid and fabricated into medical devices such as a nerve growth conduit and locally deliver folic acid to a site of injury such as a PNS injury site.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: March 8, 2022
    Assignees: Aleo BME, Inc., The Penn State Research Foundation
    Inventors: Chao Liu, Jian Yang
  • Patent number: 11259996
    Abstract: A method of using a dental filler is disclosed. The method may include securing a prosthetic to a dental implant, the prosthetic having an access channel therethrough. The method may also include filling a portion of the access channel by inserting a polytetrafluoroethylene dental plug into the access channel and compressing the polytetrafluoroethylene dental plug within the access channel.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: March 1, 2022
    Inventors: Alexander Shor, Jimmy Janakievski
  • Patent number: 11254789
    Abstract: A hydrophilic silicone, compositions comprising the same, and articles comprising the same are shown and described herein. The hydrophilic silicone is an ionically modified silicone compound wherein the compound has a net neutral charge. The hydrophilic silicone compounds may be provided as part of a composition, e.g., a composition suitable for forming a hydrogel, which may be employed to form a film material and even an article (e.g., in a contact lens).
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: February 22, 2022
    Assignee: Momentive Performance Materials Inc.
    Inventors: Meenal Mehra, Raveendra Mathad, Shreedhar Bhat
  • Patent number: 11246959
    Abstract: A biocompatible textile and methods for its use and fabrication are disclosed. The textile may be fabricated from electrospun fibers forming windings on a mandrel, in which the windings form openings having a mesh size between adjacent windings. The textile may also be fabricated by the addition of solvent-soluble particles incorporated into the textile while the windings are formed. Such particles may be removed by exposing the textile to a solvent, thereby dissolving them. Disclosed are also replacements for animal organs composed of material including at least one layer of an electrospun fiber textile having a mesh size. Such replacements for animal organs may include biocompatible textiles treated with a surface treatment process.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: February 15, 2022
    Inventor: Jed K. Johnson
  • Patent number: 11235021
    Abstract: A solid antimicrobial hydrogel comprising a first amphiphilic component. The first amphiphilic component, in its chemically cross-linked state, being a lyotropic liquid crystal and having an ordered nanostructure of hydrophobic and hydrophilic domains, the composition further comprising an antimicrobial agent being covalently attached to at least one of the hydrophilic or hydrophobic domains.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: February 1, 2022
    Assignee: AMFERIA AB
    Inventors: Anand Kumar Rajasekharan, Saba Atefykta, Martin Andersson
  • Patent number: 11229682
    Abstract: The present disclosure provides compositions and methods for treatment of a kidney disease with chemokine protein stromal cell-derived factor 1 (SDF-1), such as methods of treating a subject afflicted with or at risk of developing a kidney disease, comprising administering SDF-1 to a kidney of the subject in a treatment-effective amount.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: January 25, 2022
    Assignee: Wake Forest University Health Sciences
    Inventor: James K. Williams
  • Patent number: 11224501
    Abstract: Devices and methods for inserting an implant into skin or other tissue of a patient can include an insertion device that can enclose and support a hyaluronic thread as it is injected into a patient's skin or other tissue. The device can include a cover member, a non-tubular support member, and the thread. The cover member can have a proximal portion, a closed distal portion, and an inner cavity extending from the proximal portion toward the closed distal portion. The thread can be positioned along a longitudinal length of support member, between the support member and the cover member. The non-tubular support member can extend within the inner cavity of the cover member. The cover member can be moveable relative to the support member to expose the thread.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: January 18, 2022
    Assignee: Allergan Industrie, SAS
    Inventors: Antoine Duc, Bastien Mandaroux
  • Patent number: 11224680
    Abstract: A bio-ink composition comprises a plurality of bio-block, in which the bio-blocks can serve as basic building blocks in cell-based bioprinting. The bio-blocks, pharmaceutical compositions comprising the bio-blocks, methods of preparing artificial tissues, tissue progenitors, or multi-dimensional constructs, and methods of preparing the bio-blocks are also provided. The bio-blocks, and the multi-dimensional constructs, artificial tissues, and tissue progenitors comprising the bio-blocks or prepared by the methods described herein are useful for tissue engineering, in vitro research, stem cell differentiation, in vivo research, drug screening, drug discovery, tissue regeneration, and regenerative medicine.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: January 18, 2022
    Assignee: REVOTEK CO., LTD
    Inventors: Yujian James Kang, Xiao Zuo
  • Patent number: 11224592
    Abstract: Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of pirfenidone or pyridone analog compounds for the prevention or treatment of various fibrotic and inflammatory diseases, including disease associated with the lung, heart, kidney, liver, eye and central nervous system. In some embodiments, pirfenidone or pyridone analog compound formulations and delivery options described herein allow for efficacious local delivery of pirfenidone or pyridone analog compound. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: January 18, 2022
    Assignee: AVALYN PHARMA INC.
    Inventor: Mark William Surber
  • Patent number: 11220571
    Abstract: Process for the preparation of aqueous polyurethane dispersions, containing from 20 to 50% by weight of an anionic polyurethane having a mean particle size from 1 to 15 micron and providing films with durable low gloss aspect.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: January 11, 2022
    Assignee: Lamberti SPA
    Inventors: Stefano Carboni, Dario Conti, Karine Coget, Domenico Vetri, Giovanni Floridi, Giuseppe Li Bassi
  • Patent number: 11219702
    Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: January 11, 2022
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, David S. Scher, Roger E. Harrington, Jerbrena C. Jacobs
  • Patent number: 11213614
    Abstract: Biphasic tissue constructs that include a scaffold having one or more channels, a vascular portion comprising a hydrogel at least partially disposed in the one or more channels, and a first bioactive growth factor and a second bioactive growth factor different from the first bioactive growth factor, the first bioactive growth factor localized to the scaffold and the second bioactive growth factor localized to the vascular portion. The first bioactive growth factor may be bone morphogenetic protein 2 (BMP2) peptide and the second bioactive growth factor may be vascular endothelial growth factor (VEGF) peptide.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: January 4, 2022
    Assignee: The George Washington University
    Inventors: Lijie G. Zhang, Haitao Cui, Wei Zhu