Surgical Implant Or Material Patents (Class 424/423)
  • Patent number: 11891626
    Abstract: The present disclosure relates to discogenic cell populations, methods of deriving, and methods of using them. The presently described discogenic cell populations may be used to restore or regenerate damaged, diseased, or missing intervertebral discs of a subject. The presently described discogenic cell populations can be derived from and administered or implanted into a subject, or may be derived from an unrelated donor.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 6, 2024
    Assignee: DiscGenics, Inc.
    Inventors: Lara Ionescu Silverman, Kevin T. Foley
  • Patent number: 11883562
    Abstract: The present disclosure relates to bioactive hydrogels derived from human blood plasma. More particularly, the disclosure relates to multifunctional materials for cell encapsulation, cell culture platforms, medical treatment apparatus and methods, more particularly, hydrogels derived from human blood components and technologies for use of such materials in research, biomedical treatment, biotech and pharmaceutical industry. The disclosure further relates to 3D printable scaffolds, sponges, foams, fibers, particles, capsules, membranes and injectable systems comprising said hydrogel. Additionally, this disclosure allows for the controlled placement of biologically active components that may be delivered by the hydrogel compositions.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: January 30, 2024
    Assignee: UNIVERSIDADE DE AVEIRO
    Inventors: João Filipe Colardelle Da Luz Mano, Catarina De Almeida Custódio, Sara Catarina Nunes Da Silva Santos
  • Patent number: 11850329
    Abstract: The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: December 26, 2023
    Assignee: The General Hospital Corporation
    Inventors: Ebru Oral, Orhun K. Muratoglu
  • Patent number: 11819216
    Abstract: An embolic device for placement in a body lumen, includes: an elongated member having a linear configuration when in room temperature, the elongated member being configured to form a first three-dimensional structure in response to body temperature; wherein the elongated member comprises a first segment, a second segment, and a third segment, the second segment being located between the first segment and the third segment; wherein the first segment and the third segment are configured to change their respective shapes in response to the body temperature; and wherein the second segment that is located between the first segment and the third segment has a shape that is independent of the body temperature.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: November 21, 2023
    Assignees: STRYKER CORPORATION, STRYKER EUROPEAN OPERATIONS LIMITED
    Inventor: Hancun Chen
  • Patent number: 11779372
    Abstract: The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included.
    Type: Grant
    Filed: July 27, 2021
    Date of Patent: October 10, 2023
    Assignee: FEMASYS INC.
    Inventors: Kathy Lee-Sepsick, Lani L. L. Paxton, Jeffrey A. Marcus, Stephen N. Williams
  • Patent number: 11771550
    Abstract: This disclosure provides an apparatus, system and method for ligament augmentation strap assembly. The ligament augmentation strap assembly includes an ligament augmentation strap inserted through a hole previously drilled through two adjacent bones; and a safe-release bone fastener attached to end of the ligament augmentation strap and configured to collapse when a force greater than a threshold is applied from the ligament augmentation strap.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: October 3, 2023
    Inventor: Tarek O. Souryal
  • Patent number: 11737977
    Abstract: A cerasome delivery system for targeting activated cd44 molecule, a preparation method and use thereof: a surface of a cerasome is partially modified by a targeting ligand, the targeting ligand being a ligand which may specifically bind to an activated cd44 molecule. The cerasome delivery system may be used for the diagnosis, prevention and treatment of vulnerable plaque or diseases associated with vulnerable plaque.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: August 29, 2023
    Assignee: Beijing Inno Medicine Co., Ltd.
    Inventors: Qian Ma, Jiefang Sun
  • Patent number: 11739452
    Abstract: Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed to yield a stabilizing effect without altering morphological properties of a first fiber system. By addition of a stabilizing fiber population one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state. In one particular abstract, medical barrier materials may be formed from the electrospun materials to provide improved medical barriers for treatments.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: August 29, 2023
    Assignee: Poly-Med, Inc.
    Inventors: Michael Scott Taylor, Seth Dylan McCullen, David Shalaby
  • Patent number: 11712356
    Abstract: A folded expandable gastro-retentive device and its uses in human medical care include, inter alia, appetite suppression in a subject in need thereof. The expanded device can be included in kits.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: August 1, 2023
    Assignee: Epitomee Medical LTD
    Inventors: Nir Betser, Valery Artmanov, Ran Kapri
  • Patent number: 11684653
    Abstract: The present disclosure relates to compositions and methods for reducing virulence of microorganisms. In particular, the present invention provides HMGB1 and variants and mimetics thereof for use in reducing virulence of microorganisms (e.g., in disease).
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: June 27, 2023
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Eugene Chang, Jeannette Messer
  • Patent number: 11684498
    Abstract: A method of using a self-adjusting stent assembly includes estimating body lumen diameter(s) associated with a portion of a body lumen in which a stent assembly will be placed; determining, based on the estimated diameter(s), target expanded stent diameter(s) of the stent assembly which is to be placed in the portion of the body lumen; selecting the stent assembly for stenting the portion of the body lumen, wherein the stent assembly is configured to: expand from an initial to expanded diameters within a range of expanded diameters; wherein the range of expanded diameters is from about 9 mm to about 5.5 mm; and wherein the target expanded stent diameter(s) is/are within the range of expanded diameters; and apply a chronic radial force to a wall that forms the portion of the lumen, wherein the radial force is less than about 0.33 N/mm; and implanting the stent assembly in the portion of the body lumen.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: June 27, 2023
    Assignee: INSPIRE M.D LTD.
    Inventors: BenZion Spector, Juan Jose Rigla Cros
  • Patent number: 11642849
    Abstract: Bio-Inks and methods of using compositions comprising the bio-Inks are disclosed. 3-D tissue repair and regeneration through precise and specific formation of biodegradable tissue scaffolds in a tissue site using the bio-inks are also provided. Specific methylacrylated gelatin hydrogels (MAC) and methacrylated chitosan (MACh) preparations formulated with sucrose, a silicate-containing component (such as laponite), and/or a cross-linking agent (such as a photo-initiator or chemical initiator), as well as powdered preparations of these, are also disclosed. Kits containing these preparations are provided for point-of-care tissue repair in vivo. Superior, more complete (up to 99.85% tissue regeneration within 4 weeks applied in situ), and rapid in situ tissue repair and bone formation are also demonstrated.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: May 9, 2023
    Assignees: The Texas A&M University System, The Board of Regents, The University of Texas System
    Inventors: Venu G. Varanasi, Azhar Ilyas, Philip Roger Kramer, Taha Azimaie, Pranesh B. Aswath, Tugba Cebe
  • Patent number: 11642235
    Abstract: A gastric vest system for treating excessive weight or obesity in mammals. The gastric vest system may include a trapezoidal-shaped vest having a left edge, a right edge, an upper indentation, and a lower indentation, and the trapezoidal-shaped vest is configured to be wrapped around a stomach or a modified stomach of a mammal to cover a lesser curvature and a greater curvature of the stomach or the modified stomach.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: May 9, 2023
    Assignee: ARMISTICE CAPITAL MASTER FUND LTD.
    Inventors: Raj Nihalani, Reynz Delina
  • Patent number: 11633523
    Abstract: Provided are a method for producing a cell tissue, including a culturing step of culturing cells capable of serving as a feeder inside opening pores and communicating pores of a porous film having a plurality of the opening pores provided on a surface thereof and the communicating pores communicating mutually adjacent opening pores with one another; and a porous film including a plurality of opening pores provided on a surface thereof and communicating pores communicating mutually adjacent opening pores with one another.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: April 25, 2023
    Assignee: FUJIFILM CORPORATION
    Inventors: Koju Ito, Shun Goto, Souichi Kohashi, Kohji Nakazawa, Hiroshi Yabu
  • Patent number: 11629132
    Abstract: The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: April 18, 2023
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Sangeeta Bhatia, Jing Shan, Michelle Palmer, Nathan Ross
  • Patent number: 11596510
    Abstract: The present invention is an apparatus and method for ligation. The ligation apparatus or band provides topical active agent(s) that alleviate pain during various ligature procedures. This invention also relates to a method that includes applying a loop or band around a body part for elastomeric ligation, whereby the band material supplies a topical active agent (s) to the body part to reduce the pain of ligation.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: March 7, 2023
    Assignee: Chinook Contract Research Inc.
    Inventors: Richard N. Terry, Merle E. Olson, Nicholas D. Allan
  • Patent number: 11589992
    Abstract: A universal low-profile intercranial assembly includes a mounting plate and a low profile intercranial device composed of a static cranial implant and an interdigitating functional neurosurgical implant. The low profile intercranial device is shaped and dimensioned for mounted to the mounting plate.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: February 28, 2023
    Assignee: LONGEVITI NEURO SOLUTIONS LLC
    Inventors: Jesse Christopher, Chad R. Gordon, Bradley Rabinovitz
  • Patent number: 11576997
    Abstract: A highly safe and inexpensive bone repair material that stably exhibits high antibacterial activity for a long time in a living body by supporting a large amount of an iodine ion and is excellent in apatite forming ability and preservability. The material includes a substrate made of titanium or titanium alloy and a titanate film on a surface of the substrate, the film composed of a large number of crystalline masses having a crystal structure and containing a calcium ion and an iodine ion, wherein the mass contains layers having a Ti—O skeleton and the calcium and the iodine ions adsorbed between the layers.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: February 14, 2023
    Assignee: CHUBU UNIVERSITY EDUCATIONAL FOUNDATION
    Inventors: Seiji Yamaguchi, Morihiro Ito, Takashi Nakamura
  • Patent number: 11576925
    Abstract: Various pharmaceutical applications of low-molecular-weight hyaluronic acid (LMW-HA) fragments include: treating tumors, conjunctival diseases, xerophthalmia, vitreous opacity, myofascitis, arthritis, cardiovascular diseases, cerebral infaretion, dysmenorrhea, endometriosis, periodontal diseases, herpes zoster, burns, pains, pruritus, acute pancreatitis, and postoperative abdominal mucosal adhesions, helping with body recovery after chemotherapy and facial cosmesis, reducing subcutaneous fat etc. Moreover, an injection containing the LMW-HA fragments and a preparation method thereof are disclosed. The injection is injected into the subcutaneous fat layer of the abdomen for facial cosmesis and anti-aging.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: February 14, 2023
    Inventor: Mizhou Hui
  • Patent number: 11571449
    Abstract: The present invention provides a pharmaceutical composition including a probiotic and a prebiotic for treatment of stunting in children. More particularly, the pharmaceutical composition includes at least one Lactobacillus specie(s) as a probiotic and at least one oligosaccharide as a prebiotic. The present invention further provides a method of treatment of stunting including administering an effective amount of a pharmaceutical composition including a probiotic and a prebiotic to children in need thereof.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: February 7, 2023
    Assignee: Chr. Hansen A/S
    Inventor: Pravas Ranjan Misra
  • Patent number: 11554154
    Abstract: This invention relates to a method of treating Major depressive disorder by orally administering to a subject a composition containing a Radix Polygalae (Polygala tenuifolia Willd) extract (PDC-1421). A solid dosage form of PDC-1421 can be prepared into the gelatin capsule. The oral administration of PDC-1421 in healthy volunteers was safe and well-tolerated for the daily dose from 380 mg to 3800 mg. The composition can be administered chronically over at least 25 days; the daily dose is administered once per day, twice per day, or three times per day, wherein each dose is 380-760 mg of the botanical extraction.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: January 17, 2023
    Assignee: BIOLITE, INC.
    Inventors: Chi-Hsin Richard King, Hsien-Ming Wu, Howard Doong, Tsung-Shann Jiang
  • Patent number: 11547551
    Abstract: The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free 3-dimensional engineered tendon constructs.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: January 10, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Lisa M. Larkin, Ellen M. Arruda, Michael Smietana, Asheesh Bedi, Stoyna Novakova
  • Patent number: 11510699
    Abstract: The present disclosure describes a labor assistance system comprising a perianal support member and grip. The perianal support member includes a contact surface, an inner surface opposing the contact surface, and a rigid compression element. The contact surface has a generally continuous compression surface apex extending from the contact surface in a first direction, oriented to extend from an anterior edge to a posterior edge along a midline axis in a sagittal plane of the patient without substantially interfering with the birthing canal of the patient. The grip is coupled to the inner surface between the anterior edge and the posterior edge of the support member. The present disclosure also describes an intrapartum pelvic floor support device that is applied to tissue in the perianal and/or anococcygeal regions of the patient during an intrapartum period to support the anococcygeal region tissues and at least a portion of the pelvic floor.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: November 29, 2022
    Assignee: Stetrix, Inc.
    Inventors: David D. Blurton, Mark Buchanan
  • Patent number: 11498946
    Abstract: The present disclosure relates to a pharmaceutical composition for combination therapy for preventing or treating cancer, which contains a first pharmaceutical ingredient containing a drug conjugate wherein an anticancer agent is bound at one end of an amphiphilic peptide represented by SEQ ID NO 1 and a poloxamer; and a second pharmaceutical ingredient containing an anti-PD-L1 antibody; as active ingredients. The pharmaceutical composition significantly inhibits cancer growth in in-vivo experiments and exhibits an effect of significantly enhancing immunotherapeutic effect by activating immune cells in cancerous tissues. In particular, the pharmaceutical composition for combination therapy according to the present disclosure has superior tumor accumulation efficiency and selectivity as compared to existing anticancer agents, and is very stable with little toxicity to normal tissues other than cancerous tissues.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: November 15, 2022
    Assignee: Korea Institute of Science and Technology
    Inventors: Kwangmeyung Kim, Ju Hee Ryu, Hong Yeol Yoon, Man Kyu Shim, Suah Yang
  • Patent number: 11471561
    Abstract: An injectable composite material for bone repair comprises a biological tissue material and bioceramics in order to serve as a three-dimensional scaffold for bone regeneration. The biological tissue material consists of microfibers having a naturally cross-linked structure without additional physical or chemical cross-linking, has superior biological compatibility, and can be slowly and completely degraded in vivo. The bioceramics in the composite material serves as a reinforcing phase. When combining the biological tissue material with the bioceramics, the composite material provides a template for bone tissue regeneration to effectively induce bone growth. The injectable composite material for bone repair can be used to fill bone defects, particularly critical-sized bone defects, and can be combined with a biological agent such as bone marrow to improve its biological activity.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: October 18, 2022
    Assignee: Hangzhou Huamai Medical Devices Co., Ltd.
    Inventors: Chunhua Yu, Hua Liao, Xiaohua Yu, Tao Jiang
  • Patent number: 11471562
    Abstract: A method is provided for producing a live cartilaginous material useful for implantation into a patient. A method of treating a patient comprising implanting a cartilaginous material prepared according to the provided method in an anatomical site in a patient also is provided.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: October 18, 2022
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Hang Lin, Rocky Sung Chi Tuan, Yuanheng Yang
  • Patent number: 11471256
    Abstract: The present invention relates to a prosthesis (1) for the repair of an inguinal hernia, which prosthesis (1) is intended to be implanted by a posterior or open laparoscopic route and comprises: an openworked textile (2) made of biocompatible material, comprising a first face (2a) intended to be placed facing the biological tissues of the inguinal region, and a second face (2b) arranged opposite said first face and intended to be placed facing the peritoneum, said first face being provided with fastening means that are able to fix said textile in said biological tissues of the inguinal region, characterized in that at least a part of said second face (2b) is covered with a non-porous coating (7) composed of a material that is hydrosoluble at 37° C. and non-hydrosoluble at 25° C. The invention also relates to a method for producing such a prosthesis.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: October 18, 2022
    Assignee: SOFRADIM PRODUCTION
    Inventors: Julie Lecuivre, Xavier Bourges
  • Patent number: 11471285
    Abstract: In some embodiments, the present invention provides tissue grafts, such as vascularized bone grafts, and methods for preparing and using such tissue grafts. In some embodiments the tissue grafts are made using pluripotent stem cells, such as autologous pluripotent stem cells. In some embodiments, the tissue grafts are made by creating a digital model of a tissue portion to be replaced or repaired, such as a bone defect, partitioning the model into two or more model segments, and then producing tissue graft segments having a size and shape corresponding to that of the model segments. Such tissue graft segments may be assembled to form a tissue graft having a size and shape corresponding to that of the tissue portion to be replaced or repaired.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: October 18, 2022
    Assignee: New York Stem Cell Foundation, Inc.
    Inventor: Giuseppe Maria De Peppo
  • Patent number: 11471558
    Abstract: The present invention concerns a polyelectrolyte coating comprising at least one polycationic layer consisting of at least one polycation consisting of n repetitive units having the formula (1) and at least one polyanionic layer consisting of hyaluronic acid. The polyelectrolyte coating has a biocidal activity and the invention thus further refers to the use of said polyelectrolyte coating for producing a device, in particular a bacteriostatic medical device, more particularly an implantable device, comprising said polyelectrolyte coating, and a method for preparing said device and a kit.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: October 18, 2022
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITÉ DE STRASBOURG, PROTIP MEDICAL
    Inventors: Philippe Lavalle, Pierre Schaaf, Nihal Engin Vrana, Angela Mutschler
  • Patent number: 11464597
    Abstract: [Problem] An adhesion-preventing material having a high adhesion-preventing effect has been demanded. [Solution] An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: October 11, 2022
    Assignees: The University of Tokyo, Mochida Pharmaceutical Co., Ltd.
    Inventors: Taichi Ito, Seiichi Ohta, Norihiro Kokudo, Mitsuko Isaji, Satoshi Shimizu
  • Patent number: 11464888
    Abstract: Provided is an implant configured to fit at or near a bone defect to promote bone growth. The implant comprises an oxysterol uniformly disposed in an acellular tissue matrix (ATM). The acellular tissue matrix can be porcine collagen, which in some cases is crosslinked. The implant can contain an acellular porcine crosslinked collagen in an amount of about 5 wt. % to about 25 wt. % of the implant and an oxysterol in an amount of about 5 wt. % to about 90 wt. % of the implant. The oxysterol can be Oxy133 monohydrate or an Oxy133 polymorph. Methods of making and using the implant are further provided.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: October 11, 2022
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, Roger E. Harrington, Jerbrena C. Jacobs, David S. Scher, Daniel A. Shimko
  • Patent number: 11458226
    Abstract: Particles made of a viscoelastic medium, are injectable gel particles, and have a size, when subjected to a physiological salt solution, in the range of from 1 to 5 mm. The particles are useful in a soft tissue augmentation implant. The implant includes particles of a viscoelastic medium, wherein a major volume of the particles are injectable gel particles The implant is useful in a method of soft tissue augmentation in a mammal, including man, comprising subepidermal administration at a site in said mammal where soft tissue augmentation is desirable, of an implant.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: October 4, 2022
    Assignee: Galderma Holding SA
    Inventor: Bengt Ågerup
  • Patent number: 11446297
    Abstract: The present disclosure generally relates to methods of treating hemolytic diseases such as sickle cell anemia using kinase inhibitors, for example, compounds that inhibit the spleen tyrosine kinase (SYK). In some embodiments a method is presented to prevent thrombosis in blood vessels of patients with a hemolytic disease comprising the step of: administrating to a patient having at least one hemolytic disease a therapeutically effective amount of at least one SYK inhibitor. In some embodiments the method includes repeatedly administering the SYK kinase inhibitor to a patient.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: September 20, 2022
    Assignees: Purdue Research Foundation
    Inventors: Phillip S. Low, Francesco Turrini, Antonella Pantaleo
  • Patent number: 11439587
    Abstract: Provided herein injectable implant compositions useful for acceleration of bone fracture healing, treatment of dental or oral pathologies, and controlled drug delivery.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: September 13, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Michael Friedman, David Kirmayer, Rami Mosheiff, Jacob Rachmilewitz, Amal Khoury, Doron Steinberg
  • Patent number: 11440874
    Abstract: Ketamine derivatives and pharmaceutical compositions thereof are disclosed. When administered orally the ketamine derivatives provide increased bioavailability of ketamine in the systemic circulation. The ketamine derivatives can be used to treat neurological diseases, psychological diseases and pain.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: September 13, 2022
    Assignee: XWPHARMA LTD.
    Inventors: Jia-Ning Xiang, Xuesong Xu, Hao-Wei Shih, Wai-Si Eng
  • Patent number: 11434460
    Abstract: A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: September 6, 2022
    Assignee: CORNING INCORPORATED
    Inventors: Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Lori E Romeo
  • Patent number: 11433163
    Abstract: A composition including, (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid, is provided. Moreover, a kit which includes: a syringe, a mineral particle covered with endothelial cells and mesenchymal cells organized in 2 or more cell layers attached to the mineral particle, and hyaluronic acid, is also provided. Last, a method for filling a gap in a bone of a subject in need thereof, including contacting the gap with a composition of: (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid is provided.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: September 6, 2022
    Assignee: BONUS THERAPEUTICS LTD.
    Inventor: Shai Meretzki
  • Patent number: 11433159
    Abstract: Implantable bone compositions are provided. The implantable compositions comprise hydratable bone putties. The hydratable bone putties comprise porous ceramic granules having an average diameter from about 50 ?m to 800 ?m. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The implantable bone compositions further include collagen carriers. In some embodiments, the hydratable bone putty can be hydrated to form a non-settable flowable cohesive cement or gel. Methods of making and using the implantable compositions are also provided.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: September 6, 2022
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Ian Dunkley, Gretchen Selders
  • Patent number: 11433116
    Abstract: The present invention describes methods of treating, preventing, reducing the likelihood of having, reducing the severity of and/or slowing the progression of a medical condition related to ischemia/reperfusion in a subject using GJA1-20k as a therapeutic agent. The invention further provides a method of protecting a cell from metabolic stress, using GJA1-20k. The invention also provides for a composition and/or gene expression vector comprising GJA1-20k.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: September 6, 2022
    Assignee: Cedars-Sinai Medical Center
    Inventors: Robin Shaw, TingTing Hong, Ying Fu, Shaohua Xiao, Wassim Basheer
  • Patent number: 11419745
    Abstract: An apparatus for treating obesity comprises a volume filling device formed by at least two segments and is provided and following implantation, the device is placed resting against the stomach wall of the patient to reduce the inner volume of the stomach, thereby affecting the patient's appetite.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: August 23, 2022
    Inventor: Peter Forsell
  • Patent number: 11407168
    Abstract: Methods to fabricate objects by 3D printing of poly-4-hydroxybutyrate (P4HB) and copolymers thereof have been developed. In one method, these objects are produced by continuous fused filament fabrication using an apparatus and conditions that overcome the problems of poor feeding of the filament resulting from the low softening temperature of the filament and heat creep along the fed filament. Methods using an apparatus including a heat sink, a melt tube, a heating block and nozzle, and a transition zone between the heat sink and heating block, with the melt tube extending through the heat sink, transition zone, and heat block to the nozzle are disclosed. 3D objects are also printed by fused pellet deposition (FPD), melt extrusion deposition (MED), selective laser melting (SLM), printing of slurries and solutions using a coagulation bath, and printing using a binding solution and polymer granules.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: August 9, 2022
    Assignee: Tepha, Inc.
    Inventors: Skander Limem, Reshad Bin Harun, Matthew Dubois, David P. Martin, Said Rizk
  • Patent number: 11406533
    Abstract: Glaucoma treatment devices are disclosed. In various example, the glaucoma treatment devices include multiple microporous layers arranged together to form a microporous body configured to help facilitate evacuation of fluid from a fluid-filled body cavity, and reabsorption of the evacuated aqueous humor by the body through tissue surrounding the glaucoma treatment device. In some examples, the glaucoma treatment device includes one or more portions configured to resist cellular ingrowth, and one or more portions configured to permit cellular ingrowth.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: August 9, 2022
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Peter J. Roeber, Jeffrey C. Towler
  • Patent number: 11407855
    Abstract: We have developed a ring opening polymerization method in an aqueous dispersion for the formation of latex. By encapsulating a catalyst in micelles dispersed in water, a seeded catalytic polymerization of various monomers in water was successfully performed. An amphiphilic molecule was used to form a micelle with a hydrophobic core in water. The catalyst that was encapsulated within this structure and the formed microcapsules were used as microreactors for the formation of biodegradable elastomers.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: August 9, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Damien S. Guironnet, Danielle Harrier, Paul Kenis
  • Patent number: 11401627
    Abstract: Disclosed is a method for preparing a quantum rod/polymer fiber membrane by using electrospinning technique. The method comprises the following steps: (1) preparing a quantum rod solution; (2) preparing a polymer solution, and adding the quantum rod solution obtained in step (1) into the polymer solution so as to form an electrospinning precursor solution with a volume concentration of the quantum rods of 5%-80%; and (3) adding the electrospinning precursor solution into an electrospinning device, regulating the voltage of a generator and the receiving distance, and then performing electrospinning to prepare the quantum rod/polymer fiber membrane. By adjusting the concentration of the quantum rod solution and parameters in the electrospinning process, the method realizes directional arrangements of the quantum rods in the electrospinning process, thereby obtaining the quantum rod/polymer fiber membrane with high degree of polarization performance.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: August 2, 2022
    Assignee: SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
    Inventors: Kai Wang, Ziming Zhou, Jing Qin, Zuoliang Wen, Shang Li, Junjie Hao, Wei Chen, Xiaowei Sun
  • Patent number: 11401639
    Abstract: A non-woven chopped fiber mat includes a mixture of glass fibers and synthetic fibers. The non-woven mat is formed using a binder composition that includes a binder resin, a coupling agent, and a corrosion inhibitor. The non-woven mat is non-corrosive and resistant to volatile unsaturated monomers such as styrene, but still remains fully compatible with solvent-containing polyester resins, such that it can be used in various pultruded products.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: August 2, 2022
    Assignee: Owens Corning Intellectual Capital, LLC
    Inventors: Jianhui Wu, Kevin Spoo, Jeff Pessell
  • Patent number: 11389564
    Abstract: The present invention relates to a method for constructing a whitlockite coating on a surface of a calcium phosphate-based bioceramic substrate and a resulting coating, wherein the preparation method includes the following steps of: preparing pure calcium phosphate-based bioceramic powder firstly, then pre-firing, shaping and calcining the pure calcium phosphate-based bioceramic powder to obtain a calcium phosphate-based bioceramic substrate, placing the substrate in a solution containing Mg2+, then transferring the substrate to a high-temperature high-pressure reaction kettle for a hydrothermal reaction, and then cleaning and drying the sample to obtain a whitlockite coating.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: July 19, 2022
    Assignee: SOUTH CHINA UNIVERSITY OF TECHNOLOGY
    Inventors: Yingjun Wang, Xiaoheng Guo, Naru Zhao
  • Patent number: 11389558
    Abstract: A wound dressing including a hydropolymer matrix crosslinked with genipin and a plurality of thymol nanoparticles loaded into the hydropolymer matrix. The plurality of thymol nanoparticles has a concentration between 0.01 wt. % and 1 wt. % of dry weight of the wound dressing. The hydropolymer matrix includes gelatin, chitosan, polyvinylpyrrolidone (PVP), and carboxymethyl cellulose (CMC).
    Type: Grant
    Filed: September 12, 2020
    Date of Patent: July 19, 2022
    Inventor: Amin Mohammadi Purfard
  • Patent number: 11357885
    Abstract: A system related to the reparation of damaged veins along with the suspension of venous stasis progression by minimizing the leak reflux flow and the protection of the valve functions of the vena saphena magna, parva, perforator veins by means of exovascular or external filling agent injection in the treatment of venous stasis (which is also called varicose vein or varicose treatment).
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: June 14, 2022
    Assignee: RD GLOBAL ARASTIRMA GELISTIRME SAGLIK ILAC INSAAT YATIRIMLARI SANAYI VE TICARET ANONIM SIRKETI
    Inventor: Rasit Dinc
  • Patent number: 11346820
    Abstract: Presented are improved and more sensitive methods for measuring levels of phytoestrogens in a biological sample, and specifically in a human urine sample, employing a High Pressure Liquid Chromatography method, coupled with a photodiode array analysis detection system. Calibration curve preparation for each of a panel of phytoestrogen analytes, including daidzein, equol and genistein, are provided employing techniques that demonstrate greater accuracy and sensitivity of sample level measurement. Clinically applicable techniques suitable for large population scale screening, diet and gut microflora characterization and disease analysis and correlation in human populations, such as in at risk breast cancer populations, through monitoring of phytoestrogen levels, is disclosed.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: May 31, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventor: Maria Teresa Aguirre
  • Patent number: 11344573
    Abstract: The present invention generally relates to the treatment of gynoid lipodystrophy, and more specifically to the use of calcium (hydroxy)phosphate particles in combination with at least one compound capable of reducing local subcutaneous fat in the treatment of gynoid lipodystrophy.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: May 31, 2022
    Assignee: MERZ PHARMA GMBH & CO. KGAA
    Inventors: Harry Frank Abst, Rainer Pooth, Martina Kerscher, Thomas Hengl, Birgit Blessmann-Gurk, Sabine Otto