Surgical Implant Or Material Patents (Class 424/423)
  • Patent number: 11124897
    Abstract: Coaxial electrospinning is used to encapsulate a chitin-lignin based hybrid gel with polycaprolactone (PCL). Antibiotics and/or other bioactive agents loaded into the core and/or shell layer of the fibrous platform are released in a controlled and sustained manner that effectively inhibits both Gram-positive and Gram-negative bacteria without cytotoxicity to mammalian cells. The PCL shell layer provides longer life for the CL gels in a wet environment and allows sustainable drug release. The PCL-coated CL nanofiber scaffolds can be loaded with antimicrobial nanoparticles, antibiotics, oxygen-releasing agents, antioxidants and/or growth factors that promote healing when used as a controlled drug release dressing for chronic wounds, such as diabetic ulcers.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: September 21, 2021
    Assignee: King Abdulaziz University
    Inventors: Tuerdimaimaiti Abudula, Kalamegam Gauthaman, Ahmed Alshahrie, Numan Salah, Adnan Memic
  • Patent number: 11123397
    Abstract: Provided are pharmaceutical foam compositions comprising a peptone, a peptide hydrolysate or an enzymatically-hydrolyzed protein prepared by enzymatic hydrolysis of a full-length protein; methods of preparation and uses thereof.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: September 21, 2021
    Assignees: Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
    Inventors: Tamar Auerbach-Nevo, Ashley Deanglis, Israel Nur
  • Patent number: 11118025
    Abstract: Novel absorbable foams, lyophilizing solutions, and lyophilizing and annealing processes are disclosed. The foams are made from copolymers of glycolide and epsilon-caprolactone. The foams are useful in or as implantable medical devices.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: September 14, 2021
    Assignee: Ethicon, Inc.
    Inventors: Jackie Donners, Marc Wisnudel, Mark Timmer
  • Patent number: 11111362
    Abstract: Films for medical devices and/or packaging include polyethylene-poly(ethylene oxide) amphiphilic graft copolymers (PE-g-PEO) in their base polymer formulations of polyethylene and poly(ethylene oxide). The films may be treated to include a nitric-oxide releasing agent incorporated into the PE-g-PEO. Also, microbial agents for inclusion in medical devices are provided, which comprise: an olefin-poly(ethylene oxide) amphiphilic graft copolymer, wherein a portion of the poly(ethylene oxide) comprises end groups converted to a nitric oxide-releasing agent. The amphiphilic graft copolymer of the microbial agents may comprise a polyethylene-poly(ethylene oxide) amphiphilic graft copolymer (PE-g-PEO), a polypropylene-poly(ethylene oxide) amphiphilic graft copolymer (PP-g-PEO), or mixtures thereof.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: September 7, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Jianbin Zhang, Theresa Hermel-Davidock, Edward Bryan Coughlin
  • Patent number: 11103460
    Abstract: Embodiments of the present disclosure include devices, and methods of making such devices, for delivery of one or more active agents with short or long zero-order release kinetics. Embodiments also include implantable or injectable drug delivery systems capable of controlled release over long periods of time for therapeutic agents.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: August 31, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Paul S. Ho, Junjun Liu, Tengfei Jiang, Salomon A. Stavchansky
  • Patent number: 11090337
    Abstract: A method of generating photoreceptors is disclosed. Cell populations comprising photoreceptors and uses thereof are also disclosed.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: August 17, 2021
    Assignee: CELL CURE NEUROSCIENCES LTD
    Inventor: Osnat Bohana-Kashtan
  • Patent number: 11083719
    Abstract: The invention relates to a gel composition containing pirfenidone, which is advantageous over other cutaneously administered pharmaceutical forms known in the prior art and which can be used in treatment for the restoration of tissues with fibrotic lesions and for the prevention of fibrotic lesions.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: August 10, 2021
    Assignee: Excalibur Pharmaceuticals, Inc.
    Inventors: José Agustín Rogelio Magaña Castro, Laura Vázquez Cervantes, Juan Socorro Armendáriz Borunda
  • Patent number: 11077229
    Abstract: Methods of reducing or preventing an adverse response to an implanted or inserted material in a patient are provided. The methods include the step of treating at least a portion of an external surface of the implanted or inserted material with an effective amount of a birth tissue material coating corn position.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: August 3, 2021
    Assignee: BioDLogics, LLC
    Inventor: Timothy R. Brahm
  • Patent number: 11065201
    Abstract: The present invention relates to a composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration, for use as a medicament.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: July 20, 2021
    Assignee: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Thomas Lars Andresen, Linda Maria Bruun, Trine Bjørnbo Larsen, Rasmus Irming Jølck, Anders Elias Hansen
  • Patent number: 11060074
    Abstract: The present invention provides polymer brush constructs, for example, surfaces decorated with hyaluronan polymers, and methods of making the same. The constructs are useful as functional materials for numerous applications, e.g., as lubricants, implant coatings, bandages and other uses.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: July 13, 2021
    Assignee: Georgia Tech Research Corporation
    Inventors: Jennifer E. Curtis, M. G. Finn, Wenbin Wei, Jessica Faubel
  • Patent number: 11058534
    Abstract: Tubular prostheses are provided for use in airways, upper digestive, and urinary tracts. Each of these uses has its own specific sets of biological specifications, based on what it must contain and exclude and the physical and chemical pressures and stresses to which it is subjected. The prostheses may be made from allogeneic cells. Thus they can be manufactured and stored prior to an individual's personal need arising.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: July 13, 2021
    Assignees: Humacyte, Inc, Yale University
    Inventors: Laura Niklason, Angela Huang, Liping Zhao, Shannon Dahl
  • Patent number: 11058780
    Abstract: The present invention relates to a palpable marker composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 50,000 centipoise (cP) after administration, for use for identifying and/or locating a non palpable tumor. In one embodiment the composition the composition is a liquid before administration into the human or animal body that increases in viscosity by more than 500,000 centipoise (cP) after administration into the human or animal body.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: July 13, 2021
    Assignees: TECHNICAL UNIVERSITY OF DENMARK, NANOVI RADIOTHERAPY APS
    Inventors: Thomas Lars Andresen, Rasmus Irming Jølck, Linda Maria Bruun
  • Patent number: 11058740
    Abstract: The present disclosure relates to a composition for preventing, alleviating or treating stress diseases, containing a Platycodon grandiflorum extract as an active ingredient, and, more specifically, to a food composition for preventing or alleviating stress diseases or a pharmaceutical composition for preventing and treating stress diseases, both of which contain a Platycodon grandiflorum extract and a Citrus aurantium extract as active ingredients. A method of the present disclosure can be used for the preparation of an agent for treating depression and anxiety, which are stress diseases, with few side effects because of the use of a natural material, and a health functional food having effects of alleviating depression, anxiety and fatigue, which are stress diseases.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: July 13, 2021
    Assignee: SUNG KYUN BIOTECH CO., LTD.
    Inventors: Mi Rim Jin, Do Heon Lee, Sun Yeou Kim
  • Patent number: 11052050
    Abstract: Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Barium sulfate may also be provided to the core of the particles as a coating or absorbed within the core of the particles. The particles can be used to minimize blood flow to mammalian tissues by occluding at least a portion of a blood vessel of the mammal, or to deliver an active agent to a localized area within a body of a mammal by contacting a localized area with at least one of the particles. Farther, the particles are useful in sustained release formulations including active agent(s) for oral administration, as tracer particles for injection into the bloodstream of a mammal or for use in enhanced ultrasound imaging.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: July 6, 2021
    Assignee: Varian Medical Systems, Inc.
    Inventors: Philipp Harder, Olaf Fritz, Ulf Fritz
  • Patent number: 11045426
    Abstract: The present disclosure utilises 3D printing technology, particularly fused filament fabrication, FFF, 3D printing, in conjunction with solid and/or liquid dispensers to produce solid dosage forms, such as pharmaceutical capsules. Such solid dosage forms have a shell, which is 3D printed, and a core, which is dispensed.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: June 29, 2021
    Assignee: UNIVERSITY OF CENTRAL LANCASHIRE
    Inventors: Mohamed Albed Alhnan, Tochukwu Chijioke Okwuosa
  • Patent number: 11045580
    Abstract: An implantable medical product and method of use for substantially reducing or eliminating harsh biological responses associated with conventionally implanted medical devices, including inflammation, infection and thrombogenesis, when implanted in in a body of a warm blooded mammal. The bioremodelable pouch structure is configured and sized to receive, encase and retain an electrical medical device therein and to allow such device to be inserted into the internal region or cavity of the pouch structure; with the pouch structure formed from either: (a) first and second sheets, or (b) a single sheet having first and second sheet portions. After receiving the electrical device, the edges around the opening are closed by suturing or stapling. The medical device encased by the bioremodelable pouch structure effectively improves biological functions by promoting tissue regeneration, modulated healing of adjacent tissue or growth of new tissue when implanted in the body of the mammal.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: June 29, 2021
    Assignee: AZIYO MED, LLC
    Inventor: Robert G. Matheny
  • Patent number: 11043286
    Abstract: A system and method for design of polymeric carrier for controlled release of molecules is provided. The method includes receiving a plurality of input parameters of a polymeric carrier, a solvent, and molecules to be released from the polymeric carrier from a database and performing Molecular Dynamics (MD) simulations to estimate thermodynamic and transport properties of the polymeric carrier, the solvent and the molecules to be released using on one or more input parameters from the plurality of input parameters. Based on the estimated thermodynamic and transport properties, swelling and degradation kinetics of the polymeric carrier and release kinetics of the molecules to be released from the polymeric carrier is estimated and generating a proposed formulation based on difference between estimated released kinetics and the targeted release kinetics of the molecules.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: June 22, 2021
    Assignee: TATA CONSULTANCY SERVICES LIMITED
    Inventors: Venkataramana Runkana, Beena Rai, Aditya Pareek, Balarama Sridhar Dwadasi, Rakesh Gupta
  • Patent number: 11040020
    Abstract: A sulfonamide pharmaceutical composition. The present invention relates to a sulfonamide compound injectable preparation comprising a sulfonamide compound or a derivative thereof. The injectable preparation is prepared from the sulfonamide compound and a pharmaceutically acceptable carrier through certain preparation technologies. The sulfonamide compound injectable preparation involved in the present invention is stable and controllable in quality and effective.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: June 22, 2021
    Assignee: TIANJIN HONGRI JIAN DA KANG MEDICAL TECHNOLOGY CO., LTD
    Inventors: Yi Juang Wu, Xiaoqing Yao, Changhai Sun, Li Tian, Xinying Zhao, Zhidong Han, Chuangyu Lin
  • Patent number: 11040006
    Abstract: The present invention relates generally to topical antiviral compositions, delivery systems, and methods of using the same.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: June 22, 2021
    Assignee: Novan, Inc.
    Inventors: Kimberly McHale, Ryan Doxey, Nathan Stasko
  • Patent number: 11020343
    Abstract: The present invention relates to an intranasal pharmaceutical dosage form comprising a dosing unit comprising naloxone or a pharmaceutically acceptable salt thereof in an amount of equivalent to ?0.5 mg naloxone HC dissolved in an application fluid of a volume of ?250 ?l. Furthermore, the present invention relates to such an intranasal pharmaceutical dosage form for use in the treatment of opioid overdosing and/or at least one symptom thereof.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: June 1, 2021
    Assignee: Harm Reduction Therapeutics, Inc.
    Inventors: John Strang, Alexander Oksche, Stephen Harris, Kevin Smith, Lucie Helene Jeanne Mottier
  • Patent number: 11013824
    Abstract: An adhesive for hard tissue bonding which has a sufficient pot life and excellent biocompatibility and is replaced with bone over time, and an adhesive kit for hard tissue bonding are provided. In addition, bone cement is provided which has excellent biocompatibility and is replaced with bone over time. An adhesive for hard tissue bonding includes: a cyanoacrylate monomer; and beta-tricalcium phosphate or hydroxyapatite. An adhesive kit for hard tissue bonding includes: a liquid agent containing a cyanoacrylate monomer; and a powdery agent containing beta-tricalcium phosphate or hydroxyapatite. Bone cement includes: a cyanoacrylate polymer; and beta-tricalcium phosphate or hydroxyapatite.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: May 25, 2021
    Assignees: Chiba Institute of Technology, Fukuyamaika Corporation
    Inventors: Kazuaki Hashimoto, Hirobumi Shibata, Syuhei Aida, Shigeo Fukuyama, Takashi Meguro, Shinya Tanaka
  • Patent number: 11016120
    Abstract: A sharpening method for a probe tip of an Atomic Force Microscope (AFM) includes the steps of dripping a prepared slurry on a glass slide to form a droplet on the glass slide, where particles of the prepared slurry are diamond powder; infiltrating the tip to be sharpened with the prepared slurry; setting operation mode of the AFM to tapping in the fluid and lowering the probe into droplet till the probe cantilever beam is immersed completely in the droplet; setting vibration parameters, scanning parameters, and sharpening time, performing tip sharpening; and evaluating the sharpening results, and finishing sharpening. When the AFM works in a tapping mode in fluid, the tip of the self-excited oscillating probe is sharpened under the grinding effect of the diamond particles. The method is simple and effective, and easy to implement.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: May 25, 2021
    Inventors: Jianchao Chen, Jingxin Wu, Xiaoguang An, Guangming Song
  • Patent number: 11013832
    Abstract: The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: May 25, 2021
    Assignees: South Dakota Board of Regents, Sanford Health
    Inventors: Gopinath Mani, Sujan Lamichhane, Jordan Anderson, Tyler Remund, Patrick W. Kelly
  • Patent number: 11000635
    Abstract: Disclosed are compositions comprised of Oxidized Cellulose (OC), such as oxidized regenerated cellulose (ORC), and an antibiotic comprised of minocycline, methods of preparation thereof and uses thereof.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: May 11, 2021
    Assignees: Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
    Inventors: Eve Montia, Dwayne Looney, Theresa Scheuble, Ronen Eavri, Roi Mashiach
  • Patent number: 11000553
    Abstract: Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of recruiting stem cells or promoting healing in vivo and in vitro.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: May 11, 2021
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Hubbard Frank Burrows, III
  • Patent number: 11000631
    Abstract: Devices, systems, and methods for applying a bioactive coating to an exterior surface of an implant are disclosed. In some embodiments, the bioactive coating may be applied to the surfaces of the implant within the operating room at the time of implantation. In one embodiment, the implant may be a temporary spacer used to temporary replace an implant in a patient suffering from an infection. The temporary spacer being, for example, an antibacterial material for fighting the infection. In some embodiments, the method includes providing a mold of the implant, and providing the bioactive coating within the mold. The method may further include inserting the implant into the mold so that the exterior surface of the implant contacts the bioactive coating, and then removing the implant from the mold.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: May 11, 2021
    Assignee: Smith & Nephew, Inc.
    Inventors: John Rose, Sied William Janna, Alisha Wilson Bergin
  • Patent number: 10993797
    Abstract: An intraocular lenses having a plurality of drug-containing microspheres attached to the intraocular lens. The intraocular lenses can be used for patients undergoing cataract surgery and reduces the need for recurrent surgery, follow-up treatment or postoperative eye-drops. Also provides a method for manufacturing such an intraocular lens and the use of an intraocular lens in the treatment of cataract.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: May 4, 2021
    Assignee: VISUSNANO LIMITED
    Inventors: Elodie Jane Siney, Joanna Mary Gould, Darren Pitt, Philip Alexander
  • Patent number: 10993968
    Abstract: Methods are disclosed for the collection and processing of amniotic material in animals. These methods involve collection of amniotic material directly during parturition or cesariean section in animals for the processing of regenerative wound treatments and tissue repairs without culturing or utilization of any excess manipulation of tissue. These materials are used to effect a cosmetic result.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: May 4, 2021
    Assignee: ANICELL BIOTECH, LLC
    Inventors: Brandon Ames, Moises Barcelo-Fimbres
  • Patent number: 10993810
    Abstract: A containment body for making a spacer device or a device to be implanted in a human body that is suitable for treating a bone seat or a joint of the human body includes a base portion and side walls that extend from the base portion and that delimit between them at least one cavity, wherein the containment body has a plurality of pores and/or at least one opening, configured to place the at least one internal cavity in communication with the outside of the containment body.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: May 4, 2021
    Assignee: Cossington Limited
    Inventor: Augusto Magagnoli
  • Patent number: 10987452
    Abstract: A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.
    Type: Grant
    Filed: May 25, 2019
    Date of Patent: April 27, 2021
    Assignee: THE SPECTRANETICS CORPORATION
    Inventors: Eugene T. Michal, Daniel J. Lerner, Matthew J. Pollman
  • Patent number: 10987450
    Abstract: Provided is a lyophilized implant configured to fit at or near a bone defect to promote bone growth, the lyophilized implant containing a biodegradable polymer in an amount of about 0.1 wt. % to about 20 wt. % of the implant, mineral particles in an amount from about 0.1 wt. % to about 75 wt. % of the implant, and an oxysterol in an amount of about 5 wt. % to about 90 wt. % of the implant. Methods of making and using the implant are further provided.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: April 27, 2021
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, David S. Scher, Daniel A. Shimko
  • Patent number: 10980923
    Abstract: There are disclosed implantable medical devices and apparatus for treating implantable medical devices during production, so as to cause the implantable medical devices to have abluminal surfaces and luminal surfaces with different functional characteristics and in particular surface energies. The luminal surfaces of the medical device are preferably coated with carbon, so as to have a low surface energy, which reduces the risk of thrombi forming when implanted into a patient's vessels. The abluminal surfaces are treated so as to have a high surface energy, such that a therapeutic, preferably bioactive, material, such as a drug, can adhere to the abluminal surfaces and preferably without any need for a containment layer such as polymer or other matrix material. Once the therapeutic material has been delivered into the tissue wall, the stent can remain within the patient's vessel without leaving any delivery artefacts, as occurs with some prior art drug eluting medical devices.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: April 20, 2021
    Assignee: Cook Medical Technologies LLC
    Inventors: John Neilan, David Murray, James Butler
  • Patent number: 10975186
    Abstract: The invention relates to a process for preparing a graft copolymer comprising polyethylene, comprising the steps of: A) providing an ethylene copolymer comprising side chains having C?C bond and B) reacting the ethylene copolymer of step A) with an azide at an elevated temperature in the absence of a catalyst to obtain the graft copolymer, wherein the azide compound is an azide compound having a functional group or a polymer having an azide group.
    Type: Grant
    Filed: January 2, 2017
    Date of Patent: April 13, 2021
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Diego Mauricio Castaneda Zuniga, Peter Neuteboom, Jan Nicolaas Eddy Duchateau, Markus Busch, Sebastian Bruno Fries
  • Patent number: 10975490
    Abstract: An apparatus for etching one side of a semiconductor layer, including at least one etching tank for receiving an electrolyte, a first electrode, which is arranged to make electrical contact with the electrolyte located in the etching tank during use, at least a second electrode, which is arranged to make indirect or direct electrical contact with the semiconductor layer, at least one electric current source, which is electrically conductively connected to the first and the second electrode to produce an etching current, and at least one transport apparatus for transporting the semiconductor layer relative to the etching tank in such a way that substantially only an etching side of the semiconductor layer that is to be etched can be wetted by the electrolyte located in the etching tank during use.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: April 13, 2021
    Assignee: NexWafe GmbH
    Inventors: Stefan Reber, Kai Schillinger
  • Patent number: 10967570
    Abstract: A device and method for printing lumen tissue constructs and a 3D bioprinter are disclosed. The device has a spray sprayhead assembly and a bioprinting platform. The spray sprayhead assembly prints a biological construct on an inner surface of a lumen tissue by the bioprinting platform. Problems, such as, recurrence of thrombus and restenosis of a lumen after the lumen tissue has been transplanted for a long time, can be avoided. The biological reliability of the lumen tissue can be improved.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: April 6, 2021
    Assignee: REVOTEK CO., LTD
    Inventors: Yijun Li, Junxuan He, Zhi Jiang, Xiaolin Hu, Leqing Zhang, Deming Wang
  • Patent number: 10967100
    Abstract: The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: April 6, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Ebru Oral, Orhun K. Muratoglu
  • Patent number: 10960380
    Abstract: An adsorbent, which can be produced by a method in which a particle size, a pore size, a specific surface area or the like can be easily controlled, and is suitable for isolation of biomolecules. The adsorbent contains aggregates of calcium phosphate-based particles, and has an average pore size of 15 to 36 nanometers and a specific surface area of 40 to 90 m2/mL when measurement is carried out by mercury porosimetry.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: March 30, 2021
    Assignees: JNC CORPORATION, SofSera Corporation
    Inventors: Yoshihiro Matsumoto, Akihiro Uchida, Yasuto Umeda
  • Patent number: 10959876
    Abstract: A dental appliance is provided. The dental appliance includes a dental form configured to receive a portion of a dental arch of an individual, and an adhesive strip comprising a first side and a second side. The first side of the adhesive strip is attached to a portion of the dental form. The second side of the adhesive strip comprises a mucoadhesive configured to adhere the adhesive strip to a tongue of the individual such that the tongue of the individual can be selectively attached to the dental appliance.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: March 30, 2021
    Inventor: Martin N. Gorman
  • Patent number: 10939990
    Abstract: A laser is used to form openings within a graft material to selectively enhance permeability of a prosthesis for tissue integration therein. A feature of utilizing a laser to create the openings for tissue integration builds from its tunability. More particularly, the laser precisely places openings in any pattern and location, and on any textile that forms the graft material. Further, the power and focus of the laser is precisely adjusted to control the diameter and shape of the openings. All parameters of the openings can be controlled at will, allowing for the opportunity to selectively enhance and optimize the permeability of the graft material in a vessel.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: March 9, 2021
    Assignee: MEDTRONIC VASCULAR, INC.
    Inventors: Zachary Borglin, Matt Petruska, Keith Perkins, Julie Benton
  • Patent number: 10933172
    Abstract: Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: March 2, 2021
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Anthony J. Melkent, Brian R. Thoren, Timothy J. N. Smith, Ian D. Grant, Ian R. Dunkley
  • Patent number: 10932910
    Abstract: The present invention provides a process to functionalize nanofiber membrane (NFM) on a total joint replacement (TJR) implant surface to support bone ingrowth and reduce macrophage-associated inflammation, the process comprising amending the implant surface by laser cutting microgrooves greater than 100 ?m in depth to protect functional PCL NFM from applied loading, induce a higher amount of osteoblast cell function, increase implant-bone contact area, and serve as a reservoir for the local delivery of biomolecules to increase osseointegration of the implant; depositing aligned fibers on the implant surface, the fibers aligned in the direction of the microgrooves and collected in layers until a thickness less than 30 ?m is reached and preferably in the range of 1 ?m to 10 ?m. Biofunctionalized NFM are used to indirectly attach biomolecules on said implant surface, or extracellular matrix proteins with biomolecules are immobilized and deposited on the PCL NFM coated implant.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: March 2, 2021
    Assignee: University of Central Oklahoma
    Inventors: Morshed Khandaker, Shahram Riahinezhad, William Paul Snow
  • Patent number: 10933167
    Abstract: A composition comprising polymer particles and a carrier, wherein the polymer particles are a mixture of at least a first polymer and a second polymer, wherein the first polymer is at least partially soluble or dispersible in the carrier, and wherein the polymer particles are arranged such that they can join together to form a scaffold of polymer particles, and wherein the composition is administrable to a human or non-human animal.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: March 2, 2021
    Assignee: LOCATE THERAPEUTICS LIMITED
    Inventors: Patrick Ginty, Robin Andrew Quirk, Kevin Morris Shakesheff
  • Patent number: 10926006
    Abstract: Devices and methods for treating ischemia and reperfusion injury (IRI) are configured for sustained-release of anti-proliferative drug into the wall of a blood vessel (to prevent in-stent stenosis), and for sustained-release of leptin antagonist into the lumen to be carried by the blood and be uptaken by tissue cells that were subjected to IRI.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: February 23, 2021
    Assignee: REMODELESS CV LTD
    Inventor: Jacob Schneiderman
  • Patent number: 10918670
    Abstract: The present disclosure relates to osteoinductive putties and other implantable compositions for repair of bone defects and other medical uses. Specifically, the technology pertains to carriers for use in implantable compositions, such as osteoinductive putties. The osteoinductive putties are made entirely from donor tissue such as demineralized bone matrix, and the putties have excellent physical properties. The present disclosure relates to osteoinductive putties, carriers, compositions, implants, kits, methods of making and methods of using any of the foregoing.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: February 16, 2021
    Assignee: RTI Surgical, Inc.
    Inventor: Jordan Katz
  • Patent number: 10918742
    Abstract: Described herein are iodine-based particles which can be used as contrast agents for x-ray radiology. Also described herein are methods, software modules and hardware modules for imaging iodine-based particles.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: February 16, 2021
    Assignee: NANOPROBES, INC.
    Inventor: James F. Hainfeld
  • Patent number: 10912860
    Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: February 9, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
  • Patent number: 10913032
    Abstract: Disclosed is a 1D nanofibers quasi-aligned, grid structure cross-laminated, and pore distribution and size controlled 3D polymer nanofiber membrane, and manufacturing method thereof. A 3D polymer nanofiber membrane controlled in pore size and porosity is formed by employing an electrospinning pattern forming apparatus that includes double insulating blocks quasi-aligns nanofibers in a specific direction by transforming an electric field and includes a current collector rotatable in 90°. Additionally, the 3D polymer nanofiber membrane may be used for air filters, separator, water filters, cell culture membranes, and so on by allowing various properties thereto through a functional surface coating.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: February 9, 2021
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Il-Doo Kim, Chanhoon Kim, Su Ho Cho, Won Tae Hwang
  • Patent number: 10905802
    Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: February 2, 2021
    Assignee: Surmodics, Inc.
    Inventor: David E. Babcock
  • Patent number: 10905543
    Abstract: The present disclosure provides intra ocular implants and methods of using same to treat various refraction errors in a patient's eye.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: February 2, 2021
    Assignee: MAG OPTICS, LTD.
    Inventors: Marwan Ghabra, Hakam Ghabra
  • Patent number: 10907124
    Abstract: The present invention relates to biomimetic membrane compositions and methods for making and using them.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: February 2, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Alireza Moshaverinia, Mohammad Mahdi Hasani-Sadrabadi, Paul S. Weiss, Tara L. Aghaloo