Surgical Implant Or Material Patents (Class 424/423)
  • Patent number: 10736999
    Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: August 11, 2020
    Assignee: W.L Gore & Associates, Inc.
    Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
  • Patent number: 10736996
    Abstract: Disclosed is a method for preparing a nitric oxide-generating adherent coating, comprising: preparing a buffer solution containing polyphenol compounds, organic selenium or sulfur compounds and soluble copper salts; then contacting a base material with the solution, and washing and drying to obtain a target product. The nitric oxide-generating material prepared by the method can be used for any medical device, such as an intravascular stent, or materials and any complex-shaped base material, and has the capability of scavenging free radicals and catalyzing RSNO to produce nitrogen monoxide, and also has a response function of reduced glutathione (GSH), an antimicrobial function and all the physiological functions possessed by nitrogen monoxide.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: August 11, 2020
    Assignees: Chengdu Southwest Jiaotong University Science and, Chengdu Jiaoda Medical Science And Technology Comp
    Inventors: Zhilu Yang, Nan Huang, Jin Wang, Yajun Weng
  • Patent number: 10736839
    Abstract: The present invention relates generally to topical antiviral compositions, delivery systems, and methods of using the same.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: August 11, 2020
    Assignee: Novan, Inc.
    Inventors: Kimberly McHale, Ryan Doxey, Nathan Stasko
  • Patent number: 10729809
    Abstract: Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: August 4, 2020
    Assignee: Osiris Therapeutics, Inc.
    Inventors: Thomas E. Uveges, Jin-Qiang Kuang, Alla Danilkovitch, S. Michael Sinclair, Sandra D. Geraghty
  • Patent number: 10723996
    Abstract: The present invention refers to release matrices which include a material that can be released in a controlled way or with predefined kinetics into a surrounding medium, reaction vessels comprising said release matrices, and release system further comprising a medium which is able to dissolve the embedded material. The present invention further refers to the use of release matrices in several applications and the production method for such matrices. The present invention also relates to a method that al lows control of the release rate of materials from polymer matrices with several factors.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: July 28, 2020
    Assignee: KUHNER SHAKER GMBH
    Inventors: Sebastian Selzer, Daniel Buenger, Iason Zografou, Jochen Buechs, Doris Klee, Barbara Dittrich, Markus Jeude
  • Patent number: 10709821
    Abstract: A heart valve implant comprising a supporting stent, a heart valve element, and a skirt. The skirt includes or is formed of at least one molded body, wherein the molded body is made of dried treated bacterial cellulose that has a swelling capacity that is greater than untreated bacterial cellulose of the same type.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: July 14, 2020
    Assignee: BIOTRONIK AG
    Inventors: Jens Ulmer, Nicolas Degen, Urs Huber
  • Patent number: 10714671
    Abstract: An apparatus and method perform supersonic cold-spraying to deposit N and P-type thermoelectric semiconductor, and other polycrystalline materials on other materials of varying complex shapes. The process developed has been demonstrated for bismuth and antimony telluride formulations as well as Tetrahedrite type copper sulfosalt materials. Both thick and thin layer thermoelectric semiconductor material is deposited over small or large areas to flat and highly complex shaped surfaces and will therefore help create a far greater application set for thermoelectric generator (TEG) systems. This process when combined with other manufacturing processes allows the total additive manufacturing of complete thermoelectric generator based waste heat recovery systems. The processes also directly apply to both thermoelectric cooler (TEC) systems, thermopile devices, and other polycrystalline functional material applications.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: July 14, 2020
    Inventor: Richard C Thuss
  • Patent number: 10702815
    Abstract: Membranes suitable for use in membrane distillation are provided. Such membranes may include nano-fibrous layers with adjustable pore sizes. The membranes may include a hydrophobic nano fibrous scaffold and a thin hydrophilic protecting layer that can significantly reduce fouling and scaling problems.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: July 7, 2020
    Assignee: The Research Foundation for the State University of New York
    Inventors: Benjamin Chu, Benjamin S. Hsiao
  • Patent number: 10702631
    Abstract: A granule form e d from a tubular body having an outer surface and an inner surface separated by a matrix, and at least one core defining an opening extending through the tubular body. The outer surface of the matrix is adapted to permit fluid flow into and out of the matrix.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: July 7, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Daniel S. Oh
  • Patent number: 10695459
    Abstract: Provided are a method of manufacturing a hyaluronate-coated high-functional suture and a high-functional suture manufactured thereby, and more particularly to a method of manufacturing a high-functional suture and a high-functional suture manufactured thereby, wherein a suture for internal and external surgery derived from a conventional chemical synthetic material is coated with a hyaluronate as a biocompatible material, thus improving biocompatibility, functionality and ease of use.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: June 30, 2020
    Assignee: JINWOO BIO CO., LTD.
    Inventors: Dong Keon Kweon, Seung Hyeon Park
  • Patent number: 10695462
    Abstract: The invention disclosed herein generally provides implantable medical devices and implants that may be removed on-demand from a subject's body at any time after their implanting in the body, without necessitating invasive procedures.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: June 30, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Oded Shoseyov, Danny Porath, Ofra Benny, Yaron Bar-Lavie, Amos Ofer
  • Patent number: 10695304
    Abstract: This disclosure relates to dosage forms containing an enantiomerically enriched or pure bupropion such as enantiomeric excess of (S)-bupropion, enantiomerically enriched (S)-bupropion, or enantiomerically pure (S)-bupropion and methods of using these dosage forms. These dosage forms may be administered to human beings in a reduced amount as compared to the amount of racemic bupropion that would be administered in the same situation.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: June 30, 2020
    Assignee: AXSOME THERAPEUTICS, INC.
    Inventor: Herriot Tabuteau
  • Patent number: 10695543
    Abstract: Apparatuses and methods described herein relate to treating cancerous tumors using radiation therapy and chemotherapy. In some embodiments, a method of treatment includes administering radiation therapy targeting a tumor, isolating a segment of a vessel proximate to the tumor, and administering a dose of a chemotherapeutic agent to the segment of the vessel. The method can further include waiting a period of time after administering the radiation therapy before administering the dose of the chemotherapeutic agent. In some embodiments, a catheter device including first and second occluding elements can be used to isolate the segment of the vessel.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: June 30, 2020
    Assignee: RenovoRx, Inc.
    Inventors: Ramtin Agah, Kamran Najmabadi, Shaun R. Bagai
  • Patent number: 10688133
    Abstract: The present invention provides a method of inhibiting progression of or preventing renal disorder, the method comprising applying a cell sheet composition for inhibiting progression of or preventing renal disorder to at least one part of the surface of a kidney, wherein the part of the surface is uncovered by a fibrous capsule of the kidney. The present invention also provides a cell sheet composition for inhibiting progression of or preventing renal disorder, the cell sheet composition comprising a cell that has a function of producing a hepatocyte growth factor (HGF). The present invention also provides a method of producing a cell sheet composition for inhibiting progression of or preventing renal disorder.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: June 23, 2020
    Assignee: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Masatoshi Oka, Sachiko Sekiya, Tatsuya Shimizu, Kosaku Nitta, Teruo Okano
  • Patent number: 10688446
    Abstract: The present invention relates to a superhydrophilic biodegradable cross linked foam membrane and a process for preparation of said foam membrane from a seaweed polysaccharides by blending with amino biopolymers/amino acids/proteins/amino compounds followed by crosslinking with a naturally occurring cross linker, genipin. The foam membrane can be used as a substitute for synthetic membrane for varied applications including membrane separation for oil-water emulsions, oil-water mixtures and other aqueous-organic mixtures under ambient conditions. These foam membranes can be recycled and reused more than three times without considerable decrease in flux rate and stability. The separation methodology of the mixtures using the foam membrane of the present invention is gravity-driven and therefore, simple and energy-efficient.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: June 23, 2020
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Ramavatar Meena, Naresh Dharmashibhai Sanandiya, Jai Prakash Chaudhary, Dibyendu Mondal, Nataraj Sanna Kotrappanavar
  • Patent number: 10688222
    Abstract: Provided is a lyophilized implant configured to fit at or near a bone defect to promote bone growth, the lyophilized implant containing a biodegradable polymer in an amount of about 0.1 wt. % to about 20 wt. % of the implant, mineral particles in an amount from about 0.1 wt. % to about 75 wt. % of the implant, and an oxysterol in an amount of about 5 wt. % to about 90 wt. % of the implant. Methods of making and using the implant are further provided.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: June 23, 2020
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, David S. Scher, Daniel A. Shimko
  • Patent number: 10683470
    Abstract: Product for cleaning, sanification and hygienization, comprising a base solution with sanificant and/or hygienizing action to which probiotic bacteria and bacteriophage elements are mixed; the probiotic bacteria being preferably of the Bacillus subtilis, Bacillus megaterium and Bacillus pumilus genera, while the bacteriophage elements comprise, as an alternative or in combination, bacteriophages of the Caudavirales, Microviridae, Leviviridae, Inoviridae, Tectiviridae, Corticoviridae families.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: June 16, 2020
    Assignee: COPMA S.C.A.R.L.
    Inventors: Alberto Rodolfi, Elisabetta Caselli
  • Patent number: 10686203
    Abstract: A peptide-inorganic material composite film according to an exemplary embodiment of the present invention includes: a unit peptide including 4 to 15 amino acids, and a transition metal oxide hybridized with the unit peptide, wherein the unit peptide includes at least two tyrosines, and the plurality of unit peptides positioned adjacent to each other have a form in which the tyrosines are linked.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: June 16, 2020
    Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Ki Tae Nam, Yoon-Sik Lee, Young-O Kim, Jaehun Lee, Ik Rang Choe
  • Patent number: 10682439
    Abstract: A three-dimensional porous polyurethane scaffold for repairing central nerve injuries and a preparation method are disclosed. The scaffold includes three-dimensional porous polyurethane, wherein the compression modulus of the three-dimensional porous polyurethane is 0.001-10.0 MPa and the pore diameter is 10-200 ?m. The three-dimensional porous polyurethane scaffold has an efficient central nerve repair function without additionally inoculating functional cells or factors and can partially restore the original nerve function of tested animals, the preparation method is simple and it has a great prospect of application.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: June 16, 2020
    Assignee: SICHUAN UNIVERSITY
    Inventors: Hong Tan, Fang Fang, Jiehua Li, Yanchao Wang, Yingke Wu, Qiang Fu, Feng Luo
  • Patent number: 10662295
    Abstract: Trehalose-based hydrogels and methods of making such hydrogels are disclosed. Specifically, a method of creating a trehalose-based hydrogel, comprising the steps of: a) forming a trehalose homopolymer or co-polymer; b) preparing a cross-linker; and c) reacting the trehalose homopolymer or co-polymer with the cross-linker to form the trehalose-based hydrogel.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: May 26, 2020
    Assignee: The Regents of the University of California
    Inventor: Heather D. Maynard
  • Patent number: 10653619
    Abstract: Effective treatments of pain and/or inflammation are provided. Through the administration of a porous biodegradable drug depot film, patch, strip or sponge being implantable within a nasal or sinus cavity and having pores sized to prevent the depot from functioning as a scaffold for tissue growth, one can reduce, prevent or treat pain and/or inflammation and prevent cells from infiltrating the drug depot and laying down scaffolding cells.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: May 19, 2020
    Assignee: Medtronic, Inc.
    Inventor: Andrew J. Lowenthal Walsh
  • Patent number: 10653707
    Abstract: Topical minocycline compositions with reduced fluorescence are provided. In some instances, the compositions include an amount of a minocycline active agent associated with porous calcium particles. Also provided are methods of using the compositions, e.g., in the treatment of acne.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: May 19, 2020
    Assignee: Laboratory Skin Care, Inc.
    Inventor: Zahra Mansouri
  • Patent number: 10647879
    Abstract: A polymerizable liquid, or resin, useful for the production by additive manufacturing of a three-dimensional object of polyurethane, polyurea, or a copolymer thereof, is described. The resin includes at least one of (i) a blocked or reactive blocked prepolymer, (ii) a blocked or reactive blocked diisocyanate, or (iii) a blocked or reactive blocked diisocyanate chain extender.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: May 12, 2020
    Assignee: Carbon, Inc.
    Inventors: Jason P. Rolland, Kai Chen, Justin Poelma, James Goodrich, Robert Pinschmidt, Joseph M. DeSimone, Lloyd M. Robeson
  • Patent number: 10646454
    Abstract: An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The active delivery system includes a plurality of microcells, wherein the microcells are filled with a medium including an active ingredient and charged or magnetic particles. The microcells include an opening, and the opening is spanned by a porous diffusion layer. Because the porous diffusion layer can be blocked with the charged or magnetic particles, the rate at which the active ingredient is dispensed can be controlled with an electric or magnetic field, respectively.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 12, 2020
    Assignee: E INK CALIFORNIA, LLC
    Inventors: Lei Liu, Lin Shao, Chung Hui Lee Liu, Hui Du, Ming Wang
  • Patent number: 10646615
    Abstract: A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and a closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a homogeneous coarse external surface comprising flat crystal platelets, which shows an enhanced osteogenic response, a method of promoting bone formation, bone regeneration and/or bone repair by implanting the biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material, and a process of preparation thereof.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: May 12, 2020
    Assignee: Geistlich Pharma AG
    Inventors: Claudio Zihlmann, Michael Bufler
  • Patent number: 10640888
    Abstract: An apparatus for accumulating cross-aligned fiber in an electrospinning device, comprising a multiple segment collector including at least a first segment, a second segment, and an intermediate segment, the intermediate segment positioned between the first and second segment to collectively present an elongated cylindrical structure; at least one electrically chargeable edge conductor circumferentially resident on the first segment and circumferentially resident on the second segment; a connection point on the first segment and on the second segment, the connection points usable for mounting the elongated cylindrical structure on a drive unit to rotate around a longitudinal axis; the elongated cylindrical structure holding electrospun fiber substantially aligned with the longitudinal axis when the edge conductors are excited with a charge of opposite polarity relative to charged fiber, and attracting electrospun fiber on to its surface around the longitudinal axis at least when the edge conductors are absent
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: May 5, 2020
    Assignee: University of Central Oklahoma
    Inventor: Maurice Haff
  • Patent number: 10633766
    Abstract: An apparatus for collecting cross-aligned fiber threads, comprising an elongated assembly having a plurality of segments including at least a first segment, a second segment, and an intermediate segment, the first segment positioned at one end of the intermediate segment and the second segment positioned at an opposite end of the intermediate segment, each segment being electrically chargeable; an electrically chargeable emitter for electrospinning nanoscale fiber streams comprising charged fiber branches, the emitter having a tip positioned offset and between an edge of the first segment and an edge of the second segment; a support structure for rotating the elongated assembly about a longitudinal axis and applying an electrical charge to at least the edges of the first and second segment; at least one electrically chargeable steering electrode for attracting fiber streams, the at least one steering electrode chargeable with an electrical polarity opposing a charge applied to the emitter.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: April 28, 2020
    Assignee: University of Central Oklahoma
    Inventors: Maurice Haff, Morshed Khandaker, William Paul Snow
  • Patent number: 10624989
    Abstract: The present invention relates to an implant (10) comprising: a substrate (1) the surface of which comprising oxidized cellulose, said oxidized cellulose having a degree of oxidation ranging from 0.5 to 1, and a multilayer coating covering said substrate, said multilayer coating comprising at least a first layer (2) adjacent said substrate, said first layer being formed of chitosan, and a second layer (3) adjacent said first layer, said second layer being formed of oxidized cellulose having a degree of oxidation ranging from 0.5 to 1. The invention further relates to a method for preparing such an implant.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: April 21, 2020
    Assignee: Sofradim Production
    Inventors: Aurelie Serrero, Robert Vestberg, Suzelei Montanari
  • Patent number: 10624928
    Abstract: The present invention provides a pharmaceutical composition comprising mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier. The pharmaceutical composition is used for the treatment of the joint disease. The mesenchymal stem cells in the composition are at least one selected from the group consisting of infra-patellar fat pad stromal cells, bone marrow stem cells, Wharton's jelly stem cells and adipose derived stem cells. The concentration of the hyaluronan is in a range from 25% (v/v) to 75% (v/v). The present invention further provides a method for treating a joint disease, comprising a step of administrating a composition containing mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier to an injured joint tissue of a subject.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: April 21, 2020
    Assignee: Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
    Inventors: Dah-Ching Ding, Kun-Chi Wu
  • Patent number: 10626267
    Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: April 21, 2020
    Assignee: Colorado State University Research Foundation
    Inventors: Susan P. James, David A. Prawel, Richard L. Koch
  • Patent number: 10617526
    Abstract: Embodiments of the present technology include a method of making a bone composite graft for administration to a patient. The method may include combining a human cadaveric bone material with a plurality of polymethyl methacrylate binder particles and spincasting the combined human cadaveric bone material and polymethyl methacrylate binder particles to produce the bone composite graft. The method may also include ablating the bone composite graft to increase the surface area of bone material exposed. The human cadaveric bone material may be immobilized in the plurality of polymethyl methacrylate binder particles. The human cadaveric bone material may be present in an amount that is 50 weight percent of the bone composite graft, or less. Additionally, the bone composite graft may have a yield strength that is at least 13,000 N/cm2 and no greater than 15,000 N/cm2.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: April 14, 2020
    Assignee: ALLOSOURCE
    Inventors: Adrian C. Samaniego, Matthew J. Southard, Kenneth Blood, Richard Dempsey
  • Patent number: 10617686
    Abstract: The invention provides stable liquid formulations containing naloxone, a pharmaceutically acceptable salt or a derivative thereof. The invention further provides methods for treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering the liquid formulations of the present invention intranasally to a patient in need thereof. Further, the invention provides a method of treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering intranasally the naloxone formulations of the present invention.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: April 14, 2020
    Assignee: HIKMA PHARMACEUTICALS USA INC.
    Inventors: Kiran Amancha, Shivani Chilampalli, Thrimoorthy Potta, Ningxin Yan, Venkat R. Goskonda, Eshwaran Narayanan
  • Patent number: 10610226
    Abstract: Adjunct material and methods of using adjunct material to reinforce a staple line are provided herein. In general, adjunct material can be used to maintain a seal in tissue and prevent stapled tissue from tearing. This adjunct material can be coupled to a jaw of a surgical stapler, and can be deployed into tissue along with the staples. In some embodiments, the adjunct material can be sized and shaped so that a portion of the material extends laterally outside of the staple line and distributes strain to tissue outside of the staple line. In certain aspects, sealant can be applied to the staple line and to the adjunct material in various ways to further seal the tissue and/or prevent leaks from forming in the tissue.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: April 7, 2020
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Frederick E. Shelton, IV, Jason L. Harris, Jeffrey S. Swayze, Mark S. Zeiner, Thomas Lee Craven, Anne J. Gorman, Bret W. Smith
  • Patent number: 10609923
    Abstract: A solid material adapted to kill bacteria in planktonic, spore and biofilm states is lethal toward a wide spectrum of gram positive and gram negative bacteria as well as other microbes. The solid material includes a significant amount of one or more surfactants entrained in a crosslinked polymeric network.
    Type: Grant
    Filed: August 11, 2018
    Date of Patent: April 7, 2020
    Assignee: Next Science IP Holdings Pty Ltd
    Inventor: Matthew Franco Myntti
  • Patent number: 10603174
    Abstract: Disclosed are compositions comprising a meniscal tissue. For example, disclosed are compositions comprising a meniscal tissue, wherein the meniscal tissue comprises one or more engineered channels. Disclosed are compositions comprising a meniscal tissue comprising viable cells native to the meniscal tissue and devitalized blood vessels. Disclosed are compositions comprising a previously cryopreserved meniscal tissue, wherein after cryopreservation and subsequent thawing the meniscal tissue comprises a) cells native to the meniscal tissue and greater than 30% of the cells are viable, b) extracellular matrix that is native to the meniscal tissue, c) one or more growth factors that are native to the meniscal tissue, and d) depleted amounts of one or more types of functional immunogenic cells. Also disclosed are methods of producing and using these compositions comprising meniscal tissue.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: March 31, 2020
    Assignee: Osiris Therapeutics, Inc.
    Inventors: Alla Danilkovitch, Jinqiang Kuang, Steven Michael Sinclair
  • Patent number: 10596001
    Abstract: One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: March 24, 2020
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Thomas J. Webster, Venu Perla
  • Patent number: 10596194
    Abstract: In one embodiment, the present invention provides a composition, wherein the composition is a porous scaffold, wherein the pores of the scaffold are from 2 to 500 microns, the composition comprising: a) a cross-linkable protein selected from the group consisting of collagen and gelatin; b) a cross-linker which induces cross-linking of the cross-linkable protein; and c) a liquid.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: March 24, 2020
    Assignee: Biochange Ltd.
    Inventor: Ishay Attar
  • Patent number: 10597634
    Abstract: The invention provides a device and the use thereof in a cell experiment in vitro. This device has a polydopamine layer-carboxymethyl chitosan layer-peptide layer structure, which is capable of regulating behaviors of human pluripotent stem cells and is useful in cell culture or a cell experiment in vitro.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: March 24, 2020
    Assignee: Peking University School and Hospital of Stomatology
    Inventors: Shicheng Wei, Ping Zhou, Xiaohong Zhang, Yongliang Li, Mengke Wang
  • Patent number: 10583225
    Abstract: The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive polymer free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiaretic acid, resveratrol and propyl gallate.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: March 10, 2020
    Assignee: ANGIOSCORE, INC.
    Inventors: Ulrich Speck, Madeleine Caroline Berg
  • Patent number: 10576187
    Abstract: The present invention relates to biomaterials coated with an active agent eluting coating, wherein implantation of the coated biomaterial results in reduced implant-related complications and/or improved integration of the biomaterial into the host tissue and further relates to kits containing the coated biomaterial. The present invention also relates to methods and kits for coating the biomaterial. It is based, at least in part, on the discovery that biomaterial coated with a cytokine eluting coating resulted in the shift of early stage macrophage polarization that were associated with positive long-term effects such as minimized capsule formation and improved tissue quality and composition as compared to uncoated biomaterials.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: March 3, 2020
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Bryan Nicklaus Brown, Daniel Jordi Hachim Diaz
  • Patent number: 10576061
    Abstract: The present application describes a two-step drug delivery formulation comprising a high affinity interaction between a drug conjugate and a compound, followed by introduction of a second compound with higher affinity to the drug conjugate to facilitate drug release. Delivery methods and specific interactions are also described.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: March 3, 2020
    Assignee: McMaster University
    Inventors: Ryan Wylie, Vincent Huynh
  • Patent number: 10568990
    Abstract: The present invention provides compositions for treating soft tissue injuries comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix. Methods of making and using compositions comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix are also provided.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: February 25, 2020
    Assignee: ALLOSOURCE
    Inventors: Reginald L. Stilwell, Brent Atkinson, Yaling Shi, Brian Dittman
  • Patent number: 10556017
    Abstract: Mucus-penetrating liposomal nanoparticles and methods of making and using thereof are described herein. The nanoparticles contain one or more lipids, one or more PEG-conjugated lipids, and optionally one or more additional materials that physically and/or chemically stabilize the particles. The nanoparticle have an average diameter of about 100 nm to about 300 nm, preferably from about 100 nm to about 250 nm, more preferably from about 100 nm to about 200 nm. The particles are mobile in mucus. The liposomes can further contain one or more therapeutic, prophylactic, and/or diagnostic agent to be delivered to a mucosal surface, such as the CV tract, the colon, the nose, the lungs, and/or the eyes. The liposomes can further contain one or more CEST agents to allow real time imaging of the particles in a live animal. The particles may also further contain an imaging agent, such as a fluorescent label.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: February 11, 2020
    Assignee: The Johns Hopkins University
    Inventors: Justin Hanes, Kannie Wai Yan Chan, Michael T. McMahon, Ming Yang, Tao Yu
  • Patent number: 10558394
    Abstract: The present invention is directed to a buprenorphine sustained release delivery system capable of delivering buprenorphine, a metabolite, or a prodrug thereof for a duration of about 14 days to about 3 months. The buprenorphine sustained release delivery system includes a flowable composition and a solid implant for the sustained release of buprenorphine, a metabolite, or a prodrug thereof. The implant is produced from the flowable composition. The buprenorphine sustained release delivery system provides in situ 1-month and 3-month release profiles characterized by an exceptionally high bioavailability and minimal risk of permanent tissue damage and typically no risk of muscle necrosis.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: February 11, 2020
    Assignee: INDIVIOR UK LIMITED
    Inventors: Richard L. Norton, Andrew Watkins, Mingxing Zhou
  • Patent number: 10525105
    Abstract: A BM23 peptide is obtained by mutating and modifying BMP-2. The BM23 peptide improves stability and duration of in-vivo efficacy relative to BMP-2, has an activity of promoting the differentiation of bone marrow mesenchymal stem cells into chondrocytes and promoting the proliferation of chondrocytes and can be used for repairing cartilage and/or treating osteoarthritis.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: January 7, 2020
    Assignee: GUANGZHOU LINK HEALTH PHARMA CO., LTD.
    Inventors: Yan Song, Yuansheng Xu, Xiaoyu Lu
  • Patent number: 10524916
    Abstract: A method of manufacturing a resorbable, macroporous bioactive glass scaffold comprising approximately 15-45% CaO, 30-70% SiO2, 0-25% Na2O, 0-17% P2O5, 0-10% MgO and 0-5% CaF2 by mass percent, produced by mixing with pore forming agents and specified heat treatments.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: January 7, 2020
    Assignee: NOVABONE PRODUCTS, LLC
    Inventors: Qiang Jie, Jiang Chang, Weiming J. Gu, Jipin Zhong, Gregory J. Pomrink
  • Patent number: 10525172
    Abstract: Oriented resorbable implants made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof, have been developed that contain one or more antimicrobial agents to prevent colonization of the implants, and reduce or prevent the occurrence of infection following implantation in a patient. These oriented implants are particularly suitable for use in procedures where prolonged strength retention is necessary and there is a risk of infection. Coverings and receptacles made from poly-4-hydroxybutyrate and copolymers thereof, containing antimicrobial agents, have also been developed for use with implantable devices to prevent colonization of these devices, and to reduce or prevent the occurrence of infection following implantation of these devices in a patient. These coverings and receptacles may be used to hold, or partially or fully cover, devices such as pacemakers and neurostimulators.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: January 7, 2020
    Assignee: Tepha, Inc.
    Inventors: David P. Martin, Said Rizk, Simon F. Williams, Arikha Moses
  • Patent number: 10517902
    Abstract: The present disclosure generally pertains to methods of treating non-healing wounds. Specifically, the method includes injecting amnion fluid derived cells along the periphery of the wound. The wound is then treated with a placental membrane material including a plurality of slits for increasing the membranes capacity to expand. The slits produce a mesh-like pattern in the membrane material. The amniotic derived cells deliver to the wound electrolytes, growth factors, carbohydrates, lipids, proteins, amino acids, lactate, pyruvate, enzymes, hormones and other factors useful in wound repair. The membrane material provides a scaffolding structure supporting cell growth, prevents microbial infection and decreases the rate of passive evaporative water and heat loss. The combination of the amniotic derived cells and the membrane material protects the wound and promotes cell regeneration.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 31, 2019
    Assignee: Prime Merger Sub, LLC
    Inventors: Kenneth L. Horton, Gregory J. Yager, Howard P. Walthall, Jr.
  • Patent number: 10512707
    Abstract: The present disclosure describes, among other things, a thermo-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: December 24, 2019
    Assignee: University of Southern California
    Inventors: John J. Whalen, III, Niki Bayat, Yi Zhang, Paulo Falabella, Mark E. Thompson, Mark S. Humayun
  • Patent number: 10512495
    Abstract: A method for fabricating a medical device includes steps as follows: A degradable powder including at least one metal element is firstly provided on a target surface. A focused energy light bean is applied to sinter/cure the biodegradable powder within an oxygen-containing atmosphere; wherein the oxygen concentration of the oxygen-containing atmosphere is adjusted to provide a first oxygen concentration and a second concentration when the focused energy light is driven to a first location and second location of the target surface respectively. The aforementioned processes are then repeatedly carried out to form a three-dimensional (3D) structure of the medical device.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: December 24, 2019
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Wei-Chin Huang, Chuan-Sheng Chuang, Ching-Chih Lin, De-Yau Lin, Sung-Ho Liu, I-Chun Lai