Abstract: Polymeric or cellulosic water and/or heat degradable containers are filled with organic waste, primarily refuse foodstuffs. The containers are dissolved or melted, spilling the waste for sterilization and subsequent processing into animal feed. The containers include, or have added thereto during or after manufacturing, biocides, antioxidants, preservatives and/or antibiotics.

Abstract: Propionibacterium acidipropionici DH42 for ensiling silage and in particular high moisture corn is described. The resulting silage has improved nutrient values from ensiling and aerobic stability.

Abstract: The composition of one or more selected soluble sugars and one or more selected dicarboxylic acids into a feed supplement for ruminant animals that maintains the appropriate level of lactic acid and pH of the rumen, and optimizes the availability of energy and nutrients for milk production or growth. The composition also includes one or more selected mineral salts and/or fat, fiber or flavor freshener.

Abstract: Improved film-forming skin protectant compositions are provided which are capable of forming a long-lasting elastic barrier film when applied to skin; the compositions have particular utility as barrier teat dips, for protecting cows against mastitis, especially during their susceptible non-lactating periods. The compositions include a film-forming component (preferably a mixture of polyether polyurethane and benzoin gum) dispersed in a compatible carrier and further having a minor amount of nitrocellulose incorporated therein in order to increase the time of adherence of the composition to skin, as compared with an otherwise identical composition without nitrocellulose. The compositions may also include a germicide (e.g., chlorhexidine diacetate), and a coloring dye. The most preferred compositions include polyether polyurethane, benzoin gum, a solvent system made up of tetrahydrafuran and a lower alcohol, and chlorhexidine diacetate.

Abstract: A bolus for delivery of pulsed doses of biologically active material to a ruminant comprises a series of distinct and separate bolus elements. Each bolus element is constructed of a degradable outer sheath and a core of biologically active material. The elements are adapted to separate following administration to the ruminant, and to disperse in the rumeno-reticular sac. In due course the elements degrade or corrode to release the biologically active material. Example boli include bolus elements of different respective corrosion characteristics and, as such, are capable of releasing pulsed doses of the active material to the ruminant.

Abstract: The present invention is directed to a mixing system for an active agent delivery device. The device comprises an elongate tubular member having first and second ends and a mixing system. The mixing system enables the entire dose of active agent to be entrained in a liquid. In use, liquid is drawn into the first end of the device, the mixing system mixes the liquid and active agent within the device and the active agent entrained in the liquid is drawn out of the second end of the member and into the patient's mouth.

Abstract: This invention relates to coating formulations for coating sustained-release drug implants. The coating formulations are capable of formulations are capable of forming a porous film coat over a biologically active agent to provide a release of the active agent at a constant rate over a prolonged period of time. The pore forming agent is used in the formulation of the invention in the amount effective to regulate the release of a biologically active compound at a desired rate. Preferably, the effective amount of the pore forming agent provides long term delivery of the active agent. The invention also provides an improved implant for the sustained administration of a biologically active compound suitable for subcutaneous implantation. The invention also relates to methods for making and using the formulation and the implant of the invention.

Abstract: Spherical aggregate crystals of a phosphoric acid/lysine/magnesium composite salt represented by formula (1):R.sub.a Mg.sub.b H.sub.c PO.sub.4.(H.sub.2 O).sub.n (1)whereR is a lysine cation;a is 0.15 to 1.0;b is 1.0 to 1.42;c is 0 to 0.3;n is 0 to 10; anda+(2.times.b)+c=3.

Abstract: A process produces an L-Lysine feed supplement with a final L-Lysine purity in the range theoretically between about 35% and 80%, measured as a percent of free-base per kg, and more preferably between about 50% and 80% L-Lysine. The process comprises adding a material containing L-Lysine to an L-Lysine fermentation broth or a fraction of an L-Lysine fermentation broth. The added material being an amount which brings a final L-Lysine feed supplement with an L-Lysine purity into a range theoretically between about 35% and 80%, measured as a percent of free-base per kg, and more preferably between about 50% and 80% L-Lysine. The fraction of L-Lysine fermentation broth is obtained by any suitable separating means such as ultrafiltration or centrifugation. The process also comprises a drying step which may involve any suitable drying means such as a spray granulator, spray dryer, tray dryer, drum dryer, rotary dryer, and tunnel dryer.

Abstract: A process for formulating a ruminant food ration in which the methionine needs of the ruminant are determined, a plurality of natural or synthetic feed ingredients and the nutrient composition of each of the ingredients are identified wherein one of the ingredients is 2-hydroxy-4-(methylthio)butanoic acid or a salt, amide or ester thereof, and a ration is formulated from the identified feed ingredients to meet the determined methionine needs of the ruminant which comprises one or more grains, a hydroxy analog of methionine, and optionally a bypass fat wherein (i) the hydroxy analog of methionine is selected from the group consisting of 2-hydroxy-4-(methylthio)butanoic acid and the salts, amides and esters thereof, (ii) the hydroxy analog of methionine is added separately from any bypass fat which is included in the ration, and (iii) the ration is formulated on the basis that at least 20% of the hydroxy analog of methionine is assumed to be available for absorption by the ruminant.

Abstract: The invention provides novel compositions useful for the sustained-release of bioactive proteins. More particularly, the present invention relates to novel suspensions of somatotropin and growth hormone releasing factor, in triacetin or polyethylene glycol. Also provided are methods of using these novel compositions as vehicles for the sustained or prolonged release of the bioactive protein or peptide.

Abstract: The present invention relates to dust free, easily flowable and dosable granular compositions containing triazine, having a particle size distribution of between 40 and 400.mu. and an upper limit of particle size at 2000.mu., which can be effectively mixed with feed for administration to animals.

Abstract: Process for controlling myiasis in cattle and sheep livestock and compositions for carrying out this process.Composition for topical or parenteral use for controlling myiasis in cattle and sheep, with an effective larvicidal amount of a compound of formula I, in particular Fipronil.

Abstract: The present invention is concerned with improving the delivery of a drug from a ruminal delivery device to give a consistent delivery of drug to the ruminal environment. Thus, the invention is directed to an improved ruminal drug delivery device comprising a semipermeable membrane having an exit orifice and defining a compartment, the compartment containing a swellable osmotic agent expandable driving member, a drug to be dispensed, a density element and, optionally, a partition layer between the osmotic expandable driving member and the drug formulation, wherein the improvement comprises an essentially gas-impermeable barrier means that separates the density element from the other components within the delivery device for isolating gases evolved from the density element from the other components within the delivery device. The barrier means further includes a coupling to transfer osmotic pressure to the semipermeable wall.

Abstract: Weather-resistant protein supplement feeds for animals and methods of making same are disclosed. A trace mineral premix in the form of free-flowing granules is produced in a series of steps comprising (1) mixing a liquid binder with a relatively coarse granular feed ingredient to provide damp binder-coated cores, (2) while damp, the binder-coated cores are mixed with a trace mineral base mix, (3) the cores with their outer layers of trace minerals are mixed with substances which impart water-resistant sheaths thereto, and (4) dusting powder is applied to complete the formation of trace mineral premix granules. The premix granules are mixed with coarse granular macromineral feed ingredients, iron oxide, liquids including a water-resistant coating solution, and one or more of a proteinaceous ingredient to form weather-resistant protein supplement feed granules.

Abstract: Process for the efficient production of a substantially dust-free, free flowing granular L-Lysine in which the L-Lysine content is adjustable. Cells are removed from a fermentation broth containing L-Lysine to make a substantially cell free L-Lysine broth. Water is removed from the L-Lysine broth to form a concentrated L-Lysine broth. The L-Lysine content of the concentrated L-Lysine broth may be adjusted to be between about 35% and 76%, measured as a percent of freebase per kg, by adding material containing L-Lysine to provide an enriched L-Lysine broth. The enriched L-Lysine broth is agglomerated by means of an atomized spray of the enriched L-Lysine broth directed onto a fluidized bed of percolating L-Lysine particles. The L-Lysine particulates act as seeds for the agglomeration process wherein the L-Lysine particulates grow in size to provide a substantially dust-free, free flowing granular L-Lysine.

Abstract: The present invention relates to a method for improving the solubility of vegetable proteins. More specifically, the invention relates to methods for the solubilization of proteins in vegetable protein sources, which methods comprise treating the vegetable protein source with an efficient amount of one or more phytase enzymes, and treating the vegetable protein source with an efficient amount of one or more proteolytic enzymes. In another aspect, the invention provides animal feed additives comprising a phytase and one or more proteolytic enzymes.

Abstract: The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.

Abstract: A bolus for supplying a biologically beneficial substance to a ruminant animal, which includes a binder constituted by a rosin matrix, preferably pine rosin, together with a ballast material, such a zinc, with the biologically beneficial substance being dispersed in the binder, so that, in use, the biologically beneficial substance is released by leaching from the non-eroding body of the bolus. A pocket may be included in the body of the rosin bolus, which pocket erodes to release an additional biologically beneficial substance.

Abstract: An oil-in-water emulsion composition having a high oil content, which comprises (a) a sucrose fatty acid ester, (b) water, and (c) an oily component, wherein (i) component (c) is present in an amount of 90% by weight or more based on the total weight of components (a), (b) and (c), (ii) at least 20% by weight of the fatty acid moiety constituting component (a) are derived from a saturated fatty acid having 8 to 16 carbon atoms, an unsaturated fatty acid having 16 to 22 carbon atoms, or a mixture thereof, and the proportion of a monoester in component (a) is 60% by weight or more; and a method for producing the oil-in-water emulsion composition having a high oil content, which comprises adding, to a mixture comprising the components (a), (b) and (c), a solid which is insoluble in the mixture in an amount of 0.01 to 10% by volume based on the total volume of the components (a), (b), and (c), followed by stirring and removal of the solid.

Abstract: A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene glycol, B vitamins and minerals. The calcium content is lower than conventional calcium treatments used for this purpose. The propylene glycol gives the cow an energy boost and sweetens the taste so the cow does not object to it as it does to conventional gels and liquids. The B vitamins stimulate the cow's appetite. The minerals replace minerals lost in the milk and also help the cow absorb calcium. The composition of the present invention is in a liquid form and is preferably administered using a 200-300 cc drench gun. The end of the dispensing tube of the drench gun is placed between the teeth and cheek of the cow near the receptors that stimulate the esophageal groove reflex.

Abstract: A novel phosphoric acid-amino acid complex salt is provided which manifests insolubility in a neutral or alkaline aqueous solution and solubility in an acidic aqueous solution and has a basic amino acid, an alkaline earth metal, and phosphoric acid as main components thereof. An additive composition containing the complex salt and used in a feed for ruminant mammals excels in protection in the first compartment of the stomach of a ruminant mammal and solubility in the fourth compartment of the stomach. This additive composition improves the nutrition of the feed with respect to such a basic amino acid as lysine, a substance frequently missing in the feed for ruminant mammals.

Abstract: A method of adding a medicament (or other added ingredient) to animal feed pellets is described, in which the medicament is contained in a cohesive gel which is mixed with the feed pellets. The gel coats the pellets substantially homogeneously, and leaves little contamination of the mixing vessel.

Abstract: A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.

Abstract: A dispenser for use in a fluid environment of use which is capable of the delivery of one or a plurality of discrete active agent-containing units in any desired delivery pattern or profile. It also can provide for the initially delayed delivery of an active agent to the environment of use and for high accuracy in the timing of delivery of the active agent.

Abstract: A method of promoting weight gain in an animal by feeding the animal calcined attapulgite which reduces adverse effects of a mycotoxin present in an animal food formulation. The calcined attapulgite is obtained by heating an attapulgite clay at or above 300.degree. F. The calcined attapulgite can be fed to an animal in any form either before, after, or during intake of food by the animal. Furthermore, a mixture of calcined attapulgite and bentonite may be used, instead of calcined attapulgite itself. Also provided is an animal feed composition for promoting weight gain including calcined attapulgite. Such a composition reduces adverse effects of a mycotoxin-contaminated animal feed. The composition may further contain a bentonite clay.

Abstract: A feed additive for dairy cattle is described comprising DHA and inhibitors of microbial degradation of DHA in the rumen of the dairy cattle. A method of producing milk in dairy cattle which is enriched for DHA is also described comprising feeding the dairy cattle a feed containing the feed additive of the invention for a period of at least about 14 day, and milking the dairy cattle to obtain milk enriched for DHA.

Abstract: A rumen by-pass feed supplement in the form of a matrix containing up to about 70 percent by weight of at least one biologically active material susceptible to inactivation in the rumen, and a protective substance which is a glyceride-free mixture of aliphatic fatty acids having an Iodine Value between 10 and 20, in an amount effective to both form a fatty acid matrix with the biologically active material and a surface coating impervious to attack in the rumen. Ruminant feeds containing the rumen by-pass feed supplements are also disclosed, as well as processes for supplying the rumen by-pass feed supplements to ruminant animals.

Abstract: A method for increasing the rate and extent of fiber digestion in a ruminant after ingestion by the ruminant is described. The method includes forming an aqueous mixture including carbohydrase enzymes active on structural carbohydrates of a forage and applying the aqueous mixture to the forage prior to ingestion by the ruminant at an application ratio grater than about 20 milliliters of the aqueous mixture per pound of forage dry matter.

Abstract: The invention provides a controlled release composition comprising a compressed core containing a drug having two parallel planar surfaces (i.e. the top and bottom), and a seal coating surrounding the core except on said planar surfaces (i.e. on all lateral surfaces). The seal coating comprises a film coating of an impermeable material.

Abstract: A corn-based mixed diet comprises rumen-protected lysine, rumen-protected methionine and an appetizer preferred by the dairy cows, which makes it possible to obtain a stable and high milk production from dairy cows. A method for stably producing a high yield of milk comprises the step of feeding to dairy cows in the course of the lactation period (1) a corn-based mixed diet containing rumen-protected lysine, rumen-protected methionine, an appetizer preferred by the dairy cows and a corn-based diet or (2) rumen-protected lysine, rumen-protected methionine and a corn-based diet, an appetizer being contained in one member selected from the group consisting of the rumen-protected lysine, rumen-protected methionine and corn-based diet.

Abstract: The present invention is concerned with improving the delivery of a drug from a ruminal delivery device to give a consistent delivery of drug to the ruminal environment. Thus, the invention is directed to an improved ruminal drug delivery device comprising a semipermeable membrane having an exit orifice and defining a compartment, the compartment containing a swellable osmotic agent expandable driving member, a drug to be dispensed, a density element and, optionally, a partition layer between the osmotic expandable driving member and the drug formulation, wherein the improvement comprises an essentially gas-impermeable barrier means that separates the density element from the other components within the delivery device for isolating gases evolved from the density element from the other components within the delivery device. The barrier means further includes a coupling to transfer osmotic pressure to the semipermeable wall.

Abstract: The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation of the device being of a predetermined length of time. The delivery of the agent formulation from the dispensing device is continued until essentially all of the active agent formulation is delivered as a result of the fluid inhibition into a fluid flow path in the housing of the device and the expansion of an expansion agent in the active agent delivery chamber.

Abstract: The invention is a method of administering therapeutic iodine for treating a disorder in a mammal. The invention comprises a step of feeding said mammal an effective amount of an oxidant for an iodine species and an iodine reductant which will cause oxidation-reduction reactions upon contact with the gastric juices present in the stomach of the mammal. This is done such that molecular iodine is generated in vivo at a ratio of molecular iodine to total iodine of above at least about 0.65. The invention also discloses a non-aqueous pharmaceutically acceptable carrier with said oxidant and reductant having the ability to cause oxidation-reduction reactions upon contact with the gastric juices present in the stomach of said mammal and in an amount sufficient to generate molecular iodine, in vivo, at a ratio of molecular iodine to total iodine of above at least about 0.65.

Abstract: A method and composition which is rumen stable but intestine soluble, and therefore useful in dietary supplementation of ruminant animals with bioavailable but rumen stable forms of essential amino acids.

Abstract: A mixed feed or a feed additive, which comprises Cucurbita Seed, Plantago and Lornicera.Other crude drugs such as Safflower, Licorice, Mabiacao, Pugongying, Houttuynia and Juhua may be compounded in addition to the above crude drugs.For breeding cattle, swine, fowl, Hamachi, and the like, the above-described mixed feed, or the feed additive compounded with the marketed feed may be used.The resistance to diseases of the fed animals is improved, healthy candicidin can be maintained during the breeding, and the meat quality, egg quality, or the like is improved.

Abstract: The invention is directed to compositions useful in methods for the treatment of coccidiosis. The compositions are designed to be administered to animals infected with coccidiosis-inducing organisms and contain an osmoprotectant, e.g. betaine, and an anticoccidial agent or coccidiostat.

Abstract: This invention provides a dietary fatty acid salt product in granulated form which optionally contains one or more additional nutrient or medicament ingredients. The dietary product can function as a rumen bypass animal feed supplement, and permit a beneficial increase in the nutrient fat content of the feed. An important aspect of the invention is the encapsulation of the granules with a polymeric coating which functions as an impermeable barrier to one or more volatile organic compounds contained in the core matrix.

Abstract: An aqueous base suspension concentrate of an ionophore antibiotic or ionophore antibiotics capable of aqueous dilution (if desired) and capable (with or without such aqueous dilution) of being orally administered to an animal (eg; by drenching), said concentration comprising(I) at least one ionophore antibiotic in (II) an aqueous system containing( ) a wetting and/or surfactant agent(ii) an antifreeze agent or agents in which the ionophore antibiotic or antibiotics is or are no more than sparingly soluble,(iii) a suspension agent,(iv) optionally an antifoam agent or system,(v) optionally a preservative,(vi) optionally a de-bittering agent,(vii) optionally a pH buffering system, and(viii) water.

Abstract: A method for supplementing the amino acid levels in ruminants is provided where rumen-protected amino acids, particularly lysine and/or methionine, are used to supplement ruminant feed.

Abstract: An intra-ruminal, slow release bolus for supplying a biologically beneficial substance to a ruminant animal, wherein the beneficial substance, in the form of a relatively high density particulate such as copper oxide, is incorporated in a cylindrical block of a solid, non-toxic binding substance such as salt or sugar which in use dissolves and/or disperses within at most a few hours in the ruminant stomach, leaving the beneficial substance retained in the ruminant stomach for slow release over a period of months.

Abstract: This invention relates to fluid-imbibing delivery devices for delivering a beneficial agent to a biological environment of use. In particular, the devices include a rigid housing defining an internal compartment comprising a substantially impermeable first wall section and a second wall section permeable to fluid in the environment of use. The first wall section may be shape-retaining, with exit means and an open end, and extend for at least 85% of the entire length of the device to define the internal compartment.

Abstract: The invention relates to a solid preparation containing an oleaginous, physiologically active substance which comprises the oleaginous, physiologically active substance, calcium gluconate, a reticular matrix-forming agent, and a sticking agent. It is a stable preparation which does not give off an odor even when added to a beverage or the like.

Abstract: This invention concerns the delivery of anti-parasitic agents to ruminant animals. More particularly, the invention concerns delivery of such agents in a controlled manner to enable the agent to have maximum effect on the parasite for longer times than is possible with conventional formulations. The composition of the invention comprises a benzimidazole, macrocyclic lactone, organophosphate, salicylanilide/substituted phenol, tetramisole or pyrimidine anti-parasitic agent dispersed in a medium the solubility characteristics of which are such as to ensure that, following oral administration, controlled amounts of the anti-parasitic agent become available to the parasite, either directly or by absorption into the ruminant blood plasma, during passage of the composition through the rumen, the abomasum and the intestine.

Abstract: The invention provides a dispensing device (10) comprising a loading dose (32) (first agent delivery device) for short-term and continuous delivery of agent, retained together with a long-term dispensing device (12) (second agent delivery device) capable of long-term and continuous delivery of agent. The combination of first and second agent delivery device provides a device in which a substantially constant dose of beneficial agent is delivered to the environment of use over time. A rapid delivery of beneficial agent is followed by continuous and prolonged delivery of agent.

Abstract: The present invention is concerned with improving the delivery of a drug from a ruminal delivery device to give a consistent delivery of drug to the ruminal environment. Thus, the invention is directed to an improved ruminal drug delivery device comprising a semipermeable membrane having an exit orifice and defining a compartment, the compartment containing a swellable osmotic agent expandable driving member, a drug to be dispensed, a density element and, optionally, a partition layer between the osmotic expandable driving member and the drug formulation, wherein the improvement comprises an essentially gas-impermeable barrier means that separates the density element from the other components within the delivery device for isolating gases evolved from the density element from the other components within the delivery device. The barrier means further includes a coupling to transfer osmotic pressure to the semipermeable wall.

Abstract: A method of enhancing weight gain and feed efficiency in a ruminant, comprising administering to the ruminant a feed efficiency enhancing amount of a choline-containing composition, wherein the choline-containing composition is encapsulated in such a manner as to reduce decomposition of the choline-containing composition in the rumen of the ruminant when administered.

Abstract: Osmotically driven drug delivery devices with walls of porous hydrophobic material as the sole diffusion-limiting wall component are disclosed. Despite pores which are considerably larger than the molecular dimensions of osmotically active species in the interior of the device, despite pores which by their hydrophobic character do not permit the passage of liquid water, and despite the absence of a cellulosic semi-permeable membrane, the devices absorb water by osmosis without loss of the osmotically active species, and function in a manner analogous to osmotic pumps of the prior art. By permitting the use of hydrophobic substances as the wall material, the invention permits the device to be constructed entirely from biodegradable materials.

Abstract: A ruminant feed additive composition comprises a phosphoric acid-amino acid composite salt and a water-insoluble salt of a polyvalent-metal-sensitive water-soluble high-molecular weight substance. The composite salt contains a basic amino acid, an alkaline-earth metal and phosphoric acid, and is insoluble in neutral or alkaline aqueous solution, but is soluble in acidic aqueous solution.

Abstract: A method for releasing molecules (guest molecules) from the matrix formed by the structure of another molecule (host molecule) in a controllable manner has been invented. This method has many applications in science and industry. In addition, applications based on such molecular systems may revolutionize significant areas of medicine, in particular the treatment of cancer and of viral infection. Similar effects can also be obtained by controlled fragmentation of a source molecule, where the molecular fragments form the active principle.