Pressure Sensitive Adhesive Means Patents (Class 424/448)
  • Patent number: 10821297
    Abstract: A system for delivering energy to an isolated part of a mammalian body includes an electrically powered patch and a self-supporting adhesive film. The patch has a major surface and comprises a matrix of at least one flexible, biocompatible material which is capable of conforming to the isolated body part. The self-supporting adhesive film has a first non-tacky surface arranged and configured for releasable attachment to the patch and a second tacky surface, opposite the first surface, for adhesive attachment to the isolated body part. The releasable attachment between the self-supporting adhesive film and the electrically powered patch has a lower strength than the adhesive attachment between the film and the isolated body part. Thus, during use the electrically powered patch is removable from the self-supporting adhesive film while leaving the self-supporting adhesive film adhered to the isolated body part.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: November 3, 2020
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Curt Binner, Alexandru Paunescu
  • Patent number: 10806705
    Abstract: The present invention provides a patch comprising a backing and an adhesive layer laminated on one side of the backing, wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: October 20, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takashi Yasukochi, Atsushi Sonobe, Satoshi Amano
  • Patent number: 10745594
    Abstract: The invention relates to an adhesive composition comprising at least one latex and at least one polymer composition having a glass transition temperature ranging from ?50° C. to 0° C., said adhesive composition being particularly suitable for bonding flexible surface coverings having a high dimensional variability. The invention also relates to a membrane obtained after drying of the adhesive composition according to the invention, a combination of a flexible surface covering with an adhesive composition according to the invention, a method of application of a flexible surface covering onto a substrate as well as a substrate covered with a peelable adhesive membrane according to the invention.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: August 18, 2020
    Assignee: BOSTIK SA
    Inventors: Jessie Casimiro, Eric Verscheure
  • Patent number: 10729679
    Abstract: A pramipexole transdermal patch for treatment of neurological disorders including Parkinson's disease that may be administered on a daily basis. The pramipexole transdermal patch of the present invention preferably comprises a drug-containing layer that comprises pramipexole or a pharmaceutically acceptable salt thereof at 2% to about 15% by weight of the drug-containing layer and at least two acrylic polymers wherein each polymer may further comprise carboxyl and/or hydroxyl functional groups. The pramipexole transdermal patch of the present invention may further comprise two or more permeation enhancers with combined pramipexole solubility of great than 50 mg/mL.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 4, 2020
    Assignee: Transwell Biotech Co., Ltd.
    Inventors: Catherine Lee, Taijung Wu
  • Patent number: 10729686
    Abstract: The invention provides transdermal patches comprising an adhesive and a composition comprising naltrexone and methyl oleate or isopropyl myristate, a kit comprising a plurality of such transdermal patches, a composition comprising naltrexone and methyl oleate, such a composition for use as a medicament, and compositions comprising naltrexone and methyl oleate or isopropyl myristate for use in the treatment of alcoholism or opiate addiction.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: August 4, 2020
    Assignee: LIBERO PHARMA LIMITED
    Inventor: Ludwig Jan Weimann
  • Patent number: 10722499
    Abstract: Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR inhibitors, one or more solvents, one or more gelling agents, and one or more antioxidants. Also disclosed herein are methods to treat skin disorders using such compositions.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: July 28, 2020
    Assignee: PALVELLA THERAPEUTICS, INC.
    Inventors: Wesley Harton Kaupinen, Braham Shroot, Simon David Betson, Charles Rodney Greenaway Evans, Marc Barry Brown
  • Patent number: 10716763
    Abstract: The present invention provides a patch comprising a backing and an adhesive agent layer laminated on the backing, wherein the adhesive agent layer comprises ropinirole or a pharmaceutically acceptable salt thereof, an organic amine or an acid addition salt thereof, and an adhesive agent.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: July 21, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Naoyuki Uchida, Yasunari Michinaka
  • Patent number: 10688108
    Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: June 23, 2020
    Assignee: Leo Pharma A/S
    Inventors: Marianne Lind, Gritt Rasmussen, Mette Rydahl Sonne, Jens Hansen, Karsten Petersson
  • Patent number: 10661065
    Abstract: Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, composition of matter, and/or user interface adapted for and/or resulting from, and/or a method and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to, controlling delivery of a transdermally-delivered medication, certain embodiments including a flux controller.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: May 26, 2020
    Inventor: Neil Brereton Jackson
  • Patent number: 10653636
    Abstract: A medical active substance patch comprising a matrix of monolayer or multilayer configuration with at least one active substance-containing layer and comprising a backing layer connected with the matrix. The active substance patch is transparent or at least translucent, and in the state of having been applied to the skin of a first person, the patch has a lightness colour value L1 at a place of the skin covered by the patch which is not less than 50% and not more than 200% of a lightness colour value L2, L2 being the lightness value of the region of the skin of the same person which surrounds the applied patch. The same is true of the skin of a second or any other person, provided that for all the persons mentioned L2 is in the range from 5° to 100°, namely from 20° to 90°.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: May 19, 2020
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventor: Stefan Bracht
  • Patent number: 10639486
    Abstract: Implantable medical device (IMD) such as leadless cardiac pacemakers may include a rechargeable power source. In some cases, the IMD may include a plurality of receiving coils that may capture a non-radiative near-field energy and then convert the near-field energy into electrical energy that may be used to recharge the rechargeable power source. Accordingly, since the rechargeable power source does not have to maintain sufficient energy stores in a single charge for the entire expected life of the IMD, the power source itself and thus the IMD, may be made smaller while still meeting device longevity expectations.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: May 5, 2020
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: William J. Linder, Michael J. Kane, Jeffrey E. Stahmann, Jacob M. Ludwig, Brendan Early Koop, Daniel Joseph Landherr, Greg Paul Carpenter, Keith R. Maile
  • Patent number: 10617784
    Abstract: An article having anti-microbial effect is provided. The article includes an occlusive layer; a substrate overlaying the occlusive layer, wherein the substrate having two opposing major surfaces; a metal oxide layer overlaying the substrate, wherein the metal oxide layer comprises a metal oxide and wherein the metal oxide layer comprises less than 40 wt. % non-oxidized metal; and a metal layer overlaying the metal oxide layer.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: April 14, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Ta-Hua Yu, Döne Demirgöz, Junkang J. Liu, Badri Veeraraghavan, Narina Y. Stepanova
  • Patent number: 10610526
    Abstract: A composition suitable for use in nicotine replacement therapy products includes a nicotine product that includes a synthetic nicotine that is substantially free of one or more contaminants and/or impurities normally associated with tobacco-derived nicotine. For example, the synthetic nicotine is substantially free of one or more of nicotine-1?-N-oxide, nicotyrine, nornicotyrine, 2?,3-bipyridyl, cotinine, anabasine, and/or anatabine. The composition further comprises one or more pharmaceutically acceptable excipients, additives and/or carriers. The nicotine replacement therapy products may include any number of such products, including transdermal nicotine delivery patches, nicotine gums, synthetic chewing tobacco, synthetic snuff, and synthetic strips (e.g., dissolvable synthetic tobacco). Additionally, a method of treating nicotine addiction includes administering a nicotine replacement composition, e.g., via a nicotine replacement therapy product, to a user.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: April 7, 2020
    Assignee: NEXT GENERATION LABS, LLC
    Inventor: Michael Arnold
  • Patent number: 10590284
    Abstract: A process is described herein for applying antimicrobials to substrates to prevent the growth of biological agents. An antimicrobial-binder mixture is provided. The binder comprises guar gum, ammonium sulfate, urea, and methyl acryloid. The antimicrobial is an organo silane quarternary amine antimicrobial. The antimicrobial-binder mixture is ionized to comprise negatively charged particles. The antimicrobial-binder mixture is aerosolized to form fog. The fog is administered to the surface and dried.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: March 17, 2020
    Assignee: SANIT TECHNOLOGIES LLC
    Inventor: Joseph Giovanniello
  • Patent number: 10583043
    Abstract: The present invention relates to a backing having a three-layer structure prepared by sticking together an inner fiber layer for holding a pasty preparation, a film layer having through-holes, and an air-permeable outer fiber layer which prevents leaking out of the pasty preparation or a liquid component exuded from the pasty preparation, and also relates to an aqueous patch using the backing which can be applied for a long time.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: March 10, 2020
    Assignees: TEIKOKU SEIYAKU CO., LTD., TOYOBO CO., LTD.
    Inventors: Sadanobu Shirai, Masahiro Inazuki, Miho Ishigure, Hideo Isoda, Hiroyuki Sakamoto, Takashi Koida, Hiroyasu Sakaguchi
  • Patent number: 10582915
    Abstract: The present disclosure relates to a film for oral hemostasis and wound protection and, more particularly, to a film for oral hemostasis and wound protection which, being attached to a wound area in an oral cavity, delays or prevents microbleeds and controls medicinal component release. The film provided by the present disclosure is capable of including a polyol, an alcohol and a biodegradable polymer in the state of partial swelling, thereby locally absorbing blood or pus or arresting hemorrhage. Moreover, due to its high elongation ratio, the film provided by the present disclosure is capable of maintaining its adhesive force even when having blood, saliva and pus absorbed inside an oral cavity and conveniently deforming according to the shape of a seriously corrugated local area, which causes only slight foreign body sensation even after a long period of time of attachment on to the local area.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: March 10, 2020
    Assignee: TBM Company
    Inventor: Seiyeong Yun
  • Patent number: 10576043
    Abstract: Provided herein is a water- and sweat-resistant transdermal drug delivery system for application to the skin of a mammal that comprises a patch having a diameter between 1 and 8 cm in length and a surface area between 4 and 8 cm2. Also provided are methods of producing the transdermal drug delivery system and methods of treatment comprising the use of the transdermal drug delivery system.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: March 3, 2020
    Assignee: Avro Life Sciences, Inc.
    Inventors: Shakir Lakhani, Keean Sarani
  • Patent number: 10568845
    Abstract: The invention relates to a transdermal therapeutic system (TTS), comprising a backing layer, which is permeable to the active ingredient, at least one matrix layer, comprising fentanyl or an active agent analogous to fentanyl, based on polyacrylate and a protective layer to be removed before usage, characterized in that the polyacrylate polymer is self-adhesive, free of carboxyl groups, has a saturation solubility for fentanyl of 3 to 20 wt. %, preferably of 4 to 12 and particularly of 5 to 10 wt. % and the layers contain at least 80% of the included active ingredient in a molecularly-dispersed, dissolved form.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: February 25, 2020
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: Walter Müller, Thomas Hille
  • Patent number: 10525246
    Abstract: A system and method of using a high-aspect ratio microdevice for treating, preventing or ameliorating a medical condition is provided.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: January 7, 2020
    Assignee: NANOMED SKINCARE, INC.
    Inventor: Bai Xu
  • Patent number: 10500387
    Abstract: A microneedle unit including a microneedle having a first surface and a second surface opposite to the first surface, the microneedle being flexible and having one or more projections on the first surface, and a support member connected to the second surface of the microneedle such that the support member supports the microneedle. The support member includes an adhesive portion and a rigid portion connected to the adhesive portion, the adhesive portion is adhesive to skin and extends outside of the second surface in plan view of the second surface, and the rigid portion includes a rigid plate which is more rigid than the adhesive portion and the microneedle.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: December 10, 2019
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventors: Hiroyuki Kato, Hisami Ueno
  • Patent number: 10493027
    Abstract: A kit for mucosally administering a metastable supersaturated solution of a pharmaceutical active agent to a human patient includes a first compartment comprising a first composition comprising a pharmaceutical active agent in solution at or below equilibrium solubility, and a second composition comprising an acidic buffer. The first and second compartments maintain separation of the first and second compositions during storage, and allow for mixing of the first and second compositions to form a supersaturated solution above equilibrium solubility of the pharmaceutical active agent for immediate mucosal administration to a human patient. In one embodiment, the second composition comprises an acidic buffer and the supersaturated solution has an acidic pH. Alternatively, the second composition comprises a basic buffer and the supersaturated solution has a basic pH.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: December 3, 2019
    Assignee: MUCODEL PHARMA LLC
    Inventor: Madhu Hariharan
  • Patent number: 10485792
    Abstract: The present invention discloses a method of treating a head and neck cancer or preventing the development of pre-malignant lesions to this cancer, by administering locally to the oral cavity, a sustained release drug delivery system comprising a drug for the treatment of this cancer or for the prevention of said lesions, and at least one polymer, such that said system is attached to a surface in the oral cavity and remains attached thereto for at least 1 hour, accompanied by release of the drug and maintaining an effective therapeutic concentration thereof in the cavity, for at least 1 hour. Further are disclosed a sustained release drug delivery system and a liquid precursor varnish composition to this system.
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: November 26, 2019
    Assignees: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Michael Friedman, Rakefet Czernimski, Silvio Gutkind, Doron Steinberg, Irith Gati, Zakhar Nudelman
  • Patent number: 10485893
    Abstract: This disclosure provides for an antimicrobial pressure sensitive adhesive composition that includes a sequestered peroxide source and devices that incorporate such a composition.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: November 26, 2019
    Assignee: Sarasota Medical Products, Inc.
    Inventor: Walter F. Leise, III
  • Patent number: 10463737
    Abstract: Silicone acrylate copolymer composition, namely, silicone resin-acrylate copolymers and methods of preparing the same. The silicone acrylate composition may include a silicone resin coupled with an acrylate polymer via a linking group. The silicone acrylate composition may be formed by preparing an acrylate or a (meth)acrylate functional resin and carrying out acrylate polymerization in the presence of a functionalized resin. A silane-functional acrylate polymer may be prepared, followed by a reaction to couple a resin to the silane-functional acrylate polymer. The resulting copolymer may then be used as desired, e.g., added to a silicone and acrylate mixture to create a non-separating blend.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: November 5, 2019
    Assignee: DOW CORNING CORPORATION
    Inventors: Robert O Huber, Gary Lee Loubert, Gerald K Schalau, II, Simon Toth
  • Patent number: 10457772
    Abstract: The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: October 29, 2019
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Willy Chin, Jeannette M. Garcia, James L. Hedrick, Eunice Leong Jiayu, Shrinivas Venkataraman, Zhi Xiang Voo, Rudy J. Wojtecki, Yi Yan Yang
  • Patent number: 10456498
    Abstract: Adhesive compositions exhibiting antimicrobial properties, good stability, long shelf lives and enhanced release of antimicrobial agents are described. In certain versions, the compositions also exhibit relatively high fluid handling capacities. The adhesive compositions inhibit microbial growth by more than 2 log after 24 hours contact and particularly more than 3.5 log after 6 hours contact. Also described are various medical articles using such adhesives and related methods.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: October 29, 2019
    Assignee: Avery Dennison Corporation
    Inventor: Anne M. Wibaux
  • Patent number: 10406114
    Abstract: A method for producing an antibiotic-loaded transdermal patch including preparing a polymeric adhesive solution by dissolving a polymeric mixture in a solvent, preparing a plurality of antibiotic-loaded solid lipid nanoparticles (SLNs), forming a patch formulation by mixing the plurality of antibiotic-loaded SLNs and the polymeric adhesive solution, and forming a layer of the patch formulation on a substrate.
    Type: Grant
    Filed: June 9, 2018
    Date of Patent: September 10, 2019
    Inventors: Masoumeh Nasrollahzadeh Abyazani, Fariba Ganji, Seyed Mojtaba Taghizadeh, Ebrahim Vasheghani Farahani
  • Patent number: 10399111
    Abstract: A film is uniformly coated with a coating solution. The following formula is satisfied: 0<a×c/b<113 where (i) a is a diameter (mm) of a gravure roll, (ii) b is a ratio of a circumferential velocity of the gravure roll to a conveyance speed at which the film is conveyed, and (iii) c is a volume (mL/m2) of recesses of the gravure roll, which volume is measured per unit area of a circumferential surface of the gravure roll.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: September 3, 2019
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Ryutaro Shiba, Yasutoshi Minemoto
  • Patent number: 10369116
    Abstract: A patch includes an adhesive layer and a release liner laminated on at least one surface of a backing. The adhesive layer comprises, as an adhesive base agent, at least one selected from the group consisting of acrylate-based adhesives and rubber-based adhesives, and the adhesive layer comprises 0.3 to 5% by mass of a nonfunctional silicone oil having a kinematic viscosity of 10 to 350 cSt at 25° C.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: August 6, 2019
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Yoko Fujiwara, Takashi Yasukochi, Yuka Takagi
  • Patent number: 10335285
    Abstract: Disclosed herein are orthopedic revision systems including a base member having a collar portion and at least one stabilization portion extending outwardly from the collar portion. The systems may further include a stem member having an attachment portion and a shaft portion, the stem member configured to be received at least partially through an opening in the collar portion such that the attachment portion lies adjacent the collar portion and the shaft portion lies adjacent the at least one stabilizing portion. In a method of performing revision surgery with such orthopedic systems includes forming an opening in the collar of the base member for receipt of the stem member by removing an inner portion of the collar portion and inserting the stem member at least partially through the opening in the collar portion such that the attachment portion lies adjacent the collar portion and the shaft member lies adjacent the at least one stabilizing portion.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: July 2, 2019
    Assignee: Howmedica Osteonics Corp.
    Inventors: David Viscardi, Nicholas Olson, Jonathan You
  • Patent number: 10328034
    Abstract: Polymeric matrices for the controlled release of medicaments for the topical transdermal use comprising copolymers of acrylic and/or methacrylic acid or esters thereof having a Tg lower than 0° C., whose free carboxy groups are salified with compatible organic or inorganic bases. The matrices of the invention allow to prepare therapeutical systems for the controlled-release of active principles through the transdermal route, thus solving stability, solubility and/or bioavailability problems of the active ingredient within the matrix.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: June 25, 2019
    Assignee: BOUTY S.P.A.
    Inventors: Paola Stefanelli, Alberto Scarsetto, Maurizio Di Grigoli, Pierbruno Romelli
  • Patent number: 10292942
    Abstract: The invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: May 21, 2019
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Horstmann, Mohammad Sameti, Tobias Jung
  • Patent number: 10265334
    Abstract: Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: April 23, 2019
    Assignee: Novan, Inc.
    Inventors: Ryan Doxey, Nathan Stasko
  • Patent number: 10245497
    Abstract: An apparatus for hand protection includes a flexible sheet that extends from a first end to a second end of the flexible sheet along a length thereof. Adhesive material is located on one side of the flexible sheet. A backing layer is on the adhesive material. The flexible sheet includes at least one finger opening closer to the first end than to the second end. The flexible sheet also includes a separation extending from the second and towards the first end. The separation separates the second and into a plurality of anchors. A method enables a flexible sheet with adhesive material thereon to be applied to a person's hands. Fingers are inserted through one or more finger openings. The backing layer is removed. The flexible sheet, including anchors formed by a separation extending from an end of the flexible sheet are adhered around the person's hand.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: April 2, 2019
    Assignee: WOD SOLUTIONS INC
    Inventors: Eugene Blazhko, Aleksandr Laznik
  • Patent number: 10238648
    Abstract: An abuse deterrent transdermal patch comprising a multilaminate. The multilaminate can comprise a first layer comprising an opioid analgesic compound, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable pressure sensitive adhesive. The multilaminate can further comprise a second layer comprising an opioid antagonist, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable adhesive. In addition, the multilaminate can further comprise a barrier layer disposed between the first and second layers.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: March 26, 2019
    Assignee: BUZZZ PHARMACEUTICALS LTD.
    Inventors: Audra Lynn Stinchcomb, Dana Carmel Hammell, Stan Lee Banks, Josh Eldridge, Miroslaw Jerzy Golinski
  • Patent number: 10206604
    Abstract: The present invention relates to the field of electrotherapy and measuring by means of electric cur-rents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according is described which includes at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement.
    Type: Grant
    Filed: December 5, 2015
    Date of Patent: February 19, 2019
    Assignee: CutoSense Oy
    Inventors: Mikael Bergelin, Jan-Erik Eriksson, Max Johansson, Chunlin Xu, Ann-Sofie Leppänen, Stefan Willför, Simo Köppä, Atte Kekonen, Heimo O. Ylänen, Jari Viik, Jari Hytti
  • Patent number: 10166387
    Abstract: A wound dressing according to the present invention comprises at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement. The wound dressing according to the present invention provide a continuous, non-invasive and objective solution for monitoring chronic wound healing without disturbing the delicate healing process.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: January 1, 2019
    Assignee: CutoSense Oy
    Inventors: Mikael Bergelin, Jan-Erik Eriksson, Max Johansson, Chunlin Xu, Ann-Sofie Leppänen, Stefan Willför, Simo Köppä, Atte Kekonen, Heimo O. Ylänen, Jari Viik, Jari Hyttinen
  • Patent number: 10166199
    Abstract: The present invention relates to a transdermal patch comprising a pharmaceutical formulation, the formulation comprising ropivacaine or an opioid, a pharmaceutically-acceptable adhesive and optionally one or more excipients selected from the group consisting of carrier oils, penetration enhancers and hydrophilic materials. The present invention also relates to methods of preparation of such a pharmaceutical formulation, as well as the use of such a transdermal patch in the treatment of pain (e.g. nociceptive and/or neuropathic pain).
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: January 1, 2019
    Assignee: Buzzz Pharmaceuticals Limited
    Inventors: Chris Jones, Darren Green
  • Patent number: 10143662
    Abstract: Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: December 4, 2018
    Assignee: TEIKOKU SEIYAKU CO., LTD.
    Inventors: Mamoru Naruse, Kenichi Hattori, Kunihiko Matsushita
  • Patent number: 10144852
    Abstract: A transparent solid glue, in mass percentage comprises: 10.0%-50.0% of glycerol, 5.0%-20.0% of propylene glycol, 5.0%-30.0% of sticky substance, 1.0%-10.0% of stearic acid, 0-5.0% of vegetable oil, 0.5%-5.0% of protopine, 0.1%-5.0 of excipient, 0.1%-0.5% of preservative, and 5.0%-70.0% of deionized water, wherein the excipient is C12-16 saturated or unsaturated fatty acid salt. The prepared transparent solid glue has high initial viscosity; and the drying time is controllable so that the gluing position of the objects to be glued can be adjusted according to actual requirements, which is convenient to use, and the glue exhibits strong adhesion after completely drying. Meanwhile, the addition of protopine causes the pH of the solid glue to be between 10.49-10.99, and accordingly the solid glue is an environmentally friendly solid glue. Within a temperature range from ?5° C. to 40° C., this solid glue is widely applicable to gluing paper, wood pieces, photographic paper, paperboards and etc.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: December 4, 2018
    Assignee: Ningbo Pasco United Industry Co., Ltd.
    Inventor: Xiaohua Qian
  • Patent number: 10123978
    Abstract: A patch for a nail for treating dermatophytosis which includes a pressure-sensitive adhesive layer containing an acrylic-based pressure-sensitive adhesive and 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol or a salt thereof, wherein the acrylic-based pressure sensitive adhesive contains a copolymer of 2-ethylhexyl acrylate and N-vinylpyrrolidone, and wherein a mass ratio of the 2-ethylhexyl acrylate and the N-vinylpyrrolidone is 70:30 to 90:10.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: November 13, 2018
    Assignees: MEIJI SEIKA PHARMA CO., LTD., NICHIBAN COMPANY LIMITED
    Inventors: Koji Kawahara, Noriko Kan, Shihoko Watanabe, Kyohei Matsuo
  • Patent number: 10111959
    Abstract: The present invention pertains to antimicrobial compositions comprising inter alia at least one alkenyl- and/or alkynyl-substituted polysiloxane, at least one polysiloxane comprising silicon-bonded hydrogen atoms, and at least one hydrosilylation catalyst, as well as antimicrobial silicone gels, wound dressings, and methods of preparing the above.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: October 30, 2018
    Assignee: MÖLNLYCKE HEALTH CARE AB
    Inventors: Peter Löwenhielm, Malin Holmén, Dennis Hansson, Sofia Bergstrand, Stefan Areskoug
  • Patent number: 10100234
    Abstract: The present invention relates to an acrylic pressure-sensitive adhesive composition, and more particularly, to an acrylic pressure-sensitive adhesive composition capable of showing an excellent anti-static performance, and solving a transferring problem of additives and a problem concerning a balance of low-rate and high-rate peel strength, by comprising a) an acrylic copolymer including a monomer having a functional group capable of chelating with a metal salt, and a hydrophobic monomer and b) a metal salt.
    Type: Grant
    Filed: January 13, 2009
    Date of Patent: October 16, 2018
    Assignee: LG Chem, Ltd.
    Inventors: No Ma Kim, Jae Gwan Lee, An Na Lee
  • Patent number: 10071090
    Abstract: The present invention relates to a transdermal patch comprising oxymorphone. The present invention also relates to processes for the preparation of the transdermal patches defined herein, as well as to the use of these patches for the treatment of pain.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: September 11, 2018
    Assignee: BUZZZ PHARMACEUTICALS LIMITED
    Inventors: Audra Lynn Stinchcomb, Dana Carmel Hammell, Stan Lee Banks, Josh Eldridge, Miroslaw Jerzy Golinski
  • Patent number: 10016522
    Abstract: A vaginal preparation for the diagnosis of human female uterotubal patency and function, comprising particles having a nucleus absorbable by the tissues of the human body, and a coating for the nucleus which is dissolvable and non-absorbable by the tissues of the human body, inert and innocuous, the nucleus comprising at least one marker that can be released by the human body through an organic fluid, the coating being dissolvable and sensitive, for the purpose of the dissolution thereof, to time and/or changes in pH and/or temperature and/or another chemical/physical parameter along the route from the vaginal area to the tubal and pelvic area, the particles having a size, weight and ovoid shape corresponding approximately to those of spermatozoa.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: July 10, 2018
    Inventor: Carlo Bulletti
  • Patent number: 10016370
    Abstract: The present invention relates to compositions, devices and methods of delayed and sustained release of energy molecules for brain function to treat nocturnal hypoglycemia. The composition comprises an energy molecule required for human brain function; wherein the release of the energy molecule is delayed and then sustained over a period of time. The device is a transdermal delivery device comprising a reservoir layer containing the composition and a skin permeation enhancer formulation, an adhesive layer, a backing layer and a release liner. The method comprises administering the composition either orally or through the transdermal delivery device to a subject in need thereof immediately prior to going to sleep.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: July 10, 2018
    Assignee: Able Cerebral, LLC
    Inventor: Jun Xia
  • Patent number: 10016164
    Abstract: A system and method are provided for the design and assembly of a device including a sensor capable and a compatible matrix material incorporated into a dressing. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions, and the matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: July 10, 2018
    Assignee: The General Hospital Corporation
    Inventors: Conor L. Evans, Gabriela Apiou, Reginald Birngruber, Alexander J. Nichols, Emmanouil Rousakis, Zongxi Li
  • Patent number: 10016545
    Abstract: A composite wound dressing and delivery apparatus includes a substantially transparent dressing layer having a lower surface that is coated with a pressure sensitive for applying the dressing layer over a wound to define a reservoir in which a negative pressure may be maintained. A substantially transparent backing layer adhered to the lower surface of the dressing layer in a releasable manner, and a vacuum port is centrally located on the dressing layer. The vacuum port is adapted to provide fluid communication between a vacuum source and the reservoir through the dressing layer. A targeting grid associated with either the dressing layer or the backing layer includes regularly spaced reference marks along at least two axes extending from the vacuum port.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: July 10, 2018
    Assignee: Smith & Nephew, Inc.
    Inventors: Ronald F. Vitaris, Julia-Rose Anderson, Deirdre McKeown, Adam M. Ruggles
  • Patent number: 9974754
    Abstract: Provided is a patch providing sufficiently high absorbability of dexmedetomidine and less skin irritation. Hydrous adhesive patch comprising dexmedetomidine or a salt thereof and a water-soluble polymer.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: May 22, 2018
    Assignees: MARUISHI PHARMACEUTICAL CO., LTD., KYUKYU PHARMACEUTICAL CO., LTD.
    Inventors: Yuhiro Yamazaki, Nobuhiro Nosaka
  • Patent number: 9962349
    Abstract: The present invention relates to a high adhesion dermal therapeutic system comprising an adhesive polymeric matrix with a salt of Diclofenac.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: May 8, 2018
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Giovanni Gennari, Anna Maria Zanellato, Patrizia Santi, Cristina Padula