Pressure Sensitive Adhesive Means Patents (Class 424/448)
  • Patent number: 10463737
    Abstract: Silicone acrylate copolymer composition, namely, silicone resin-acrylate copolymers and methods of preparing the same. The silicone acrylate composition may include a silicone resin coupled with an acrylate polymer via a linking group. The silicone acrylate composition may be formed by preparing an acrylate or a (meth)acrylate functional resin and carrying out acrylate polymerization in the presence of a functionalized resin. A silane-functional acrylate polymer may be prepared, followed by a reaction to couple a resin to the silane-functional acrylate polymer. The resulting copolymer may then be used as desired, e.g., added to a silicone and acrylate mixture to create a non-separating blend.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: November 5, 2019
    Assignee: DOW CORNING CORPORATION
    Inventors: Robert O Huber, Gary Lee Loubert, Gerald K Schalau, II, Simon Toth
  • Patent number: 10456498
    Abstract: Adhesive compositions exhibiting antimicrobial properties, good stability, long shelf lives and enhanced release of antimicrobial agents are described. In certain versions, the compositions also exhibit relatively high fluid handling capacities. The adhesive compositions inhibit microbial growth by more than 2 log after 24 hours contact and particularly more than 3.5 log after 6 hours contact. Also described are various medical articles using such adhesives and related methods.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: October 29, 2019
    Assignee: Avery Dennison Corporation
    Inventor: Anne M. Wibaux
  • Patent number: 10457772
    Abstract: The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: October 29, 2019
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Willy Chin, Jeannette M. Garcia, James L. Hedrick, Eunice Leong Jiayu, Shrinivas Venkataraman, Zhi Xiang Voo, Rudy J. Wojtecki, Yi Yan Yang
  • Patent number: 10406114
    Abstract: A method for producing an antibiotic-loaded transdermal patch including preparing a polymeric adhesive solution by dissolving a polymeric mixture in a solvent, preparing a plurality of antibiotic-loaded solid lipid nanoparticles (SLNs), forming a patch formulation by mixing the plurality of antibiotic-loaded SLNs and the polymeric adhesive solution, and forming a layer of the patch formulation on a substrate.
    Type: Grant
    Filed: June 9, 2018
    Date of Patent: September 10, 2019
    Inventors: Masoumeh Nasrollahzadeh Abyazani, Fariba Ganji, Seyed Mojtaba Taghizadeh, Ebrahim Vasheghani Farahani
  • Patent number: 10399111
    Abstract: A film is uniformly coated with a coating solution. The following formula is satisfied: 0<a×c/b<113 where (i) a is a diameter (mm) of a gravure roll, (ii) b is a ratio of a circumferential velocity of the gravure roll to a conveyance speed at which the film is conveyed, and (iii) c is a volume (mL/m2) of recesses of the gravure roll, which volume is measured per unit area of a circumferential surface of the gravure roll.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: September 3, 2019
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Ryutaro Shiba, Yasutoshi Minemoto
  • Patent number: 10369116
    Abstract: A patch includes an adhesive layer and a release liner laminated on at least one surface of a backing. The adhesive layer comprises, as an adhesive base agent, at least one selected from the group consisting of acrylate-based adhesives and rubber-based adhesives, and the adhesive layer comprises 0.3 to 5% by mass of a nonfunctional silicone oil having a kinematic viscosity of 10 to 350 cSt at 25° C.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: August 6, 2019
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Yoko Fujiwara, Takashi Yasukochi, Yuka Takagi
  • Patent number: 10335285
    Abstract: Disclosed herein are orthopedic revision systems including a base member having a collar portion and at least one stabilization portion extending outwardly from the collar portion. The systems may further include a stem member having an attachment portion and a shaft portion, the stem member configured to be received at least partially through an opening in the collar portion such that the attachment portion lies adjacent the collar portion and the shaft portion lies adjacent the at least one stabilizing portion. In a method of performing revision surgery with such orthopedic systems includes forming an opening in the collar of the base member for receipt of the stem member by removing an inner portion of the collar portion and inserting the stem member at least partially through the opening in the collar portion such that the attachment portion lies adjacent the collar portion and the shaft member lies adjacent the at least one stabilizing portion.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: July 2, 2019
    Assignee: Howmedica Osteonics Corp.
    Inventors: David Viscardi, Nicholas Olson, Jonathan You
  • Patent number: 10328034
    Abstract: Polymeric matrices for the controlled release of medicaments for the topical transdermal use comprising copolymers of acrylic and/or methacrylic acid or esters thereof having a Tg lower than 0° C., whose free carboxy groups are salified with compatible organic or inorganic bases. The matrices of the invention allow to prepare therapeutical systems for the controlled-release of active principles through the transdermal route, thus solving stability, solubility and/or bioavailability problems of the active ingredient within the matrix.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: June 25, 2019
    Assignee: BOUTY S.P.A.
    Inventors: Paola Stefanelli, Alberto Scarsetto, Maurizio Di Grigoli, Pierbruno Romelli
  • Patent number: 10292942
    Abstract: The invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: May 21, 2019
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Horstmann, Mohammad Sameti, Tobias Jung
  • Patent number: 10265334
    Abstract: Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: April 23, 2019
    Assignee: Novan, Inc.
    Inventors: Ryan Doxey, Nathan Stasko
  • Patent number: 10245497
    Abstract: An apparatus for hand protection includes a flexible sheet that extends from a first end to a second end of the flexible sheet along a length thereof. Adhesive material is located on one side of the flexible sheet. A backing layer is on the adhesive material. The flexible sheet includes at least one finger opening closer to the first end than to the second end. The flexible sheet also includes a separation extending from the second and towards the first end. The separation separates the second and into a plurality of anchors. A method enables a flexible sheet with adhesive material thereon to be applied to a person's hands. Fingers are inserted through one or more finger openings. The backing layer is removed. The flexible sheet, including anchors formed by a separation extending from an end of the flexible sheet are adhered around the person's hand.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: April 2, 2019
    Assignee: WOD SOLUTIONS INC
    Inventors: Eugene Blazhko, Aleksandr Laznik
  • Patent number: 10238648
    Abstract: An abuse deterrent transdermal patch comprising a multilaminate. The multilaminate can comprise a first layer comprising an opioid analgesic compound, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable pressure sensitive adhesive. The multilaminate can further comprise a second layer comprising an opioid antagonist, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable adhesive. In addition, the multilaminate can further comprise a barrier layer disposed between the first and second layers.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: March 26, 2019
    Assignee: BUZZZ PHARMACEUTICALS LTD.
    Inventors: Audra Lynn Stinchcomb, Dana Carmel Hammell, Stan Lee Banks, Josh Eldridge, Miroslaw Jerzy Golinski
  • Patent number: 10206604
    Abstract: The present invention relates to the field of electrotherapy and measuring by means of electric cur-rents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according is described which includes at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement.
    Type: Grant
    Filed: December 5, 2015
    Date of Patent: February 19, 2019
    Assignee: CutoSense Oy
    Inventors: Mikael Bergelin, Jan-Erik Eriksson, Max Johansson, Chunlin Xu, Ann-Sofie Leppänen, Stefan Willför, Simo Köppä, Atte Kekonen, Heimo O. Ylänen, Jari Viik, Jari Hytti
  • Patent number: 10166387
    Abstract: A wound dressing according to the present invention comprises at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement. The wound dressing according to the present invention provide a continuous, non-invasive and objective solution for monitoring chronic wound healing without disturbing the delicate healing process.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: January 1, 2019
    Assignee: CutoSense Oy
    Inventors: Mikael Bergelin, Jan-Erik Eriksson, Max Johansson, Chunlin Xu, Ann-Sofie Leppänen, Stefan Willför, Simo Köppä, Atte Kekonen, Heimo O. Ylänen, Jari Viik, Jari Hyttinen
  • Patent number: 10166199
    Abstract: The present invention relates to a transdermal patch comprising a pharmaceutical formulation, the formulation comprising ropivacaine or an opioid, a pharmaceutically-acceptable adhesive and optionally one or more excipients selected from the group consisting of carrier oils, penetration enhancers and hydrophilic materials. The present invention also relates to methods of preparation of such a pharmaceutical formulation, as well as the use of such a transdermal patch in the treatment of pain (e.g. nociceptive and/or neuropathic pain).
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: January 1, 2019
    Assignee: Buzzz Pharmaceuticals Limited
    Inventors: Chris Jones, Darren Green
  • Patent number: 10143662
    Abstract: Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: December 4, 2018
    Assignee: TEIKOKU SEIYAKU CO., LTD.
    Inventors: Mamoru Naruse, Kenichi Hattori, Kunihiko Matsushita
  • Patent number: 10144852
    Abstract: A transparent solid glue, in mass percentage comprises: 10.0%-50.0% of glycerol, 5.0%-20.0% of propylene glycol, 5.0%-30.0% of sticky substance, 1.0%-10.0% of stearic acid, 0-5.0% of vegetable oil, 0.5%-5.0% of protopine, 0.1%-5.0 of excipient, 0.1%-0.5% of preservative, and 5.0%-70.0% of deionized water, wherein the excipient is C12-16 saturated or unsaturated fatty acid salt. The prepared transparent solid glue has high initial viscosity; and the drying time is controllable so that the gluing position of the objects to be glued can be adjusted according to actual requirements, which is convenient to use, and the glue exhibits strong adhesion after completely drying. Meanwhile, the addition of protopine causes the pH of the solid glue to be between 10.49-10.99, and accordingly the solid glue is an environmentally friendly solid glue. Within a temperature range from ?5° C. to 40° C., this solid glue is widely applicable to gluing paper, wood pieces, photographic paper, paperboards and etc.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: December 4, 2018
    Assignee: Ningbo Pasco United Industry Co., Ltd.
    Inventor: Xiaohua Qian
  • Patent number: 10123978
    Abstract: A patch for a nail for treating dermatophytosis which includes a pressure-sensitive adhesive layer containing an acrylic-based pressure-sensitive adhesive and 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol or a salt thereof, wherein the acrylic-based pressure sensitive adhesive contains a copolymer of 2-ethylhexyl acrylate and N-vinylpyrrolidone, and wherein a mass ratio of the 2-ethylhexyl acrylate and the N-vinylpyrrolidone is 70:30 to 90:10.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: November 13, 2018
    Assignees: MEIJI SEIKA PHARMA CO., LTD., NICHIBAN COMPANY LIMITED
    Inventors: Koji Kawahara, Noriko Kan, Shihoko Watanabe, Kyohei Matsuo
  • Patent number: 10111959
    Abstract: The present invention pertains to antimicrobial compositions comprising inter alia at least one alkenyl- and/or alkynyl-substituted polysiloxane, at least one polysiloxane comprising silicon-bonded hydrogen atoms, and at least one hydrosilylation catalyst, as well as antimicrobial silicone gels, wound dressings, and methods of preparing the above.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: October 30, 2018
    Assignee: MÖLNLYCKE HEALTH CARE AB
    Inventors: Peter Löwenhielm, Malin Holmén, Dennis Hansson, Sofia Bergstrand, Stefan Areskoug
  • Patent number: 10100234
    Abstract: The present invention relates to an acrylic pressure-sensitive adhesive composition, and more particularly, to an acrylic pressure-sensitive adhesive composition capable of showing an excellent anti-static performance, and solving a transferring problem of additives and a problem concerning a balance of low-rate and high-rate peel strength, by comprising a) an acrylic copolymer including a monomer having a functional group capable of chelating with a metal salt, and a hydrophobic monomer and b) a metal salt.
    Type: Grant
    Filed: January 13, 2009
    Date of Patent: October 16, 2018
    Assignee: LG Chem, Ltd.
    Inventors: No Ma Kim, Jae Gwan Lee, An Na Lee
  • Patent number: 10071090
    Abstract: The present invention relates to a transdermal patch comprising oxymorphone. The present invention also relates to processes for the preparation of the transdermal patches defined herein, as well as to the use of these patches for the treatment of pain.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: September 11, 2018
    Assignee: BUZZZ PHARMACEUTICALS LIMITED
    Inventors: Audra Lynn Stinchcomb, Dana Carmel Hammell, Stan Lee Banks, Josh Eldridge, Miroslaw Jerzy Golinski
  • Patent number: 10016522
    Abstract: A vaginal preparation for the diagnosis of human female uterotubal patency and function, comprising particles having a nucleus absorbable by the tissues of the human body, and a coating for the nucleus which is dissolvable and non-absorbable by the tissues of the human body, inert and innocuous, the nucleus comprising at least one marker that can be released by the human body through an organic fluid, the coating being dissolvable and sensitive, for the purpose of the dissolution thereof, to time and/or changes in pH and/or temperature and/or another chemical/physical parameter along the route from the vaginal area to the tubal and pelvic area, the particles having a size, weight and ovoid shape corresponding approximately to those of spermatozoa.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: July 10, 2018
    Inventor: Carlo Bulletti
  • Patent number: 10016370
    Abstract: The present invention relates to compositions, devices and methods of delayed and sustained release of energy molecules for brain function to treat nocturnal hypoglycemia. The composition comprises an energy molecule required for human brain function; wherein the release of the energy molecule is delayed and then sustained over a period of time. The device is a transdermal delivery device comprising a reservoir layer containing the composition and a skin permeation enhancer formulation, an adhesive layer, a backing layer and a release liner. The method comprises administering the composition either orally or through the transdermal delivery device to a subject in need thereof immediately prior to going to sleep.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: July 10, 2018
    Assignee: Able Cerebral, LLC
    Inventor: Jun Xia
  • Patent number: 10016164
    Abstract: A system and method are provided for the design and assembly of a device including a sensor capable and a compatible matrix material incorporated into a dressing. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions, and the matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: July 10, 2018
    Assignee: The General Hospital Corporation
    Inventors: Conor L. Evans, Gabriela Apiou, Reginald Birngruber, Alexander J. Nichols, Emmanouil Rousakis, Zongxi Li
  • Patent number: 10016545
    Abstract: A composite wound dressing and delivery apparatus includes a substantially transparent dressing layer having a lower surface that is coated with a pressure sensitive for applying the dressing layer over a wound to define a reservoir in which a negative pressure may be maintained. A substantially transparent backing layer adhered to the lower surface of the dressing layer in a releasable manner, and a vacuum port is centrally located on the dressing layer. The vacuum port is adapted to provide fluid communication between a vacuum source and the reservoir through the dressing layer. A targeting grid associated with either the dressing layer or the backing layer includes regularly spaced reference marks along at least two axes extending from the vacuum port.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: July 10, 2018
    Assignee: Smith & Nephew, Inc.
    Inventors: Ronald F. Vitaris, Julia-Rose Anderson, Deirdre McKeown, Adam M. Ruggles
  • Patent number: 9974754
    Abstract: Provided is a patch providing sufficiently high absorbability of dexmedetomidine and less skin irritation. Hydrous adhesive patch comprising dexmedetomidine or a salt thereof and a water-soluble polymer.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: May 22, 2018
    Assignees: MARUISHI PHARMACEUTICAL CO., LTD., KYUKYU PHARMACEUTICAL CO., LTD.
    Inventors: Yuhiro Yamazaki, Nobuhiro Nosaka
  • Patent number: 9962349
    Abstract: The present invention relates to a high adhesion dermal therapeutic system comprising an adhesive polymeric matrix with a salt of Diclofenac.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: May 8, 2018
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Giovanni Gennari, Anna Maria Zanellato, Patrizia Santi, Cristina Padula
  • Patent number: 9962458
    Abstract: A super absorbent, honey-dosed foam/fiber composite, gap patterned wound dressing, comprising: a patterned foam/fiber composite structure having a gap patterned side and a non-gap patterned side, wherein the patterned side includes a pattern of foam/fiber gaps disposed between foam/fiber areas dosed with honey, where the pattern of foam/fiber gaps is formed by the honey-dosed areas, such that the patterned foam/fiber composite structure includes a layer of super absorbent material located substantially adjacent to the honey-dosed areas; and wherein a wound in contact with the gap patterned side discharges an exudate which substantially collects in the individual ones of the foam/fiber gaps causing honey in the individual ones of the honey-dosed areas to be substantially dispersed throughout a wound treatment zone and a portion of the exudate that is collected in the individual ones of the foam/fiber gaps is transferred to and collected in the super absorbent material.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: May 8, 2018
    Assignee: Links Medical Products Incorporated
    Inventors: Howard Kenneth Payne, Gregory Frank Devenish
  • Patent number: 9967988
    Abstract: Disclosed is a retention system for an electronic device including a base member for receiving the electronic device, a retention pad attached to the base member, a plurality of adhesive portions of the retention pad wherein the adhesive portions are dispersed, generally, in a gradient across the retention pad.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: May 8, 2018
    Assignee: Henge Docks LLC
    Inventors: Matthew Leigh Vroom, Brandon Parod, Lyle Livingston-Guanzon, Laura Mei
  • Patent number: 9931307
    Abstract: Provided is a transdermal delivery system consisting of a backing layer, a drug-containing matrix layer, and a release layer, wherein the drug-containing matrix layer includes (a) donepezil or a pharmaceutically acceptable salt thereof as an active ingredient, (b) a mixture of high molecular weight polyisobutylene having a weight-average molecular weight ranging from 400,000 to 3,000,000 and low molecular weight polyisobutylene having a weight-average molecular weight ranging from 25,000 to 300,000 as an adhesive, and (c) a permeation enhancer in not more than 3% by weight based on the total weight of the drug-containing matrix layer.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: April 3, 2018
    Assignee: DAEWOONG PHARMACEUTICAL CO., LTD.
    Inventors: Yo-Han Choi, Hee-Chul Chang
  • Patent number: 9926470
    Abstract: A two-phase adhesive composition and selective debonding agent are described. The adhesive composition comprises a substantially continuous first phase comprising a pressure sensitive adhesive and a discontinuous second phase comprising crosslinked silicone gel microparticles. When applied, the selective debonding agent is absorbed by the gel microparticles. The gel microparticles change size or shape and facilitate debonding the adhesive from a substrate by decreasing the contact area between the adhesive and the substrate. Methods to selectively debond pressure sensitive adhesive compositions, methods of making the pressure sensitive adhesive compositions, articles that utilize the pressure sensitive adhesive composition, adhesive systems, and kits that include an article containing the pressure sensitive adhesive composition and the selective debonding agent, are also described.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: March 27, 2018
    Assignee: Avery Dennison Corporation
    Inventor: Neal Carty
  • Patent number: 9919141
    Abstract: A method for manufacturing a needle-shaped body, including supplying a first aqueous solution to an intaglio plate, supplying a second aqueous solution to the intaglio plate, drying the first and second aqueous solutions in the intaglio plate such that a dried body is formed on the intaglio plate, and separating the dried body from the intaglio plate such that a needle-shaped body including a needle-shaped projection and a support base which supports the needle-shaped projection is obtained. The intaglio plate includes a recess corresponding to the needle-shaped projection, the first aqueous solution is supplied to fill at least a portion of the recess, the first aqueous solution and the second aqueous solution are immiscible, the first aqueous solution forms a projection side layer in the needle-shaped body, and the second aqueous solution forms a support base side layer on the projection side layer in the needle-shaped body.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: March 20, 2018
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventors: Hanae Tagami, Hiroyuki Kato
  • Patent number: 9907767
    Abstract: The present invention relates to methods of treating overactive bladder and the symptoms associated therewith, for example, urinary urgency, frequency of mictruitions, nocturia, and urgency urinary incontinence. One treatment method according to the present invention comprises treatment with the beta-3 adrenergic receptor agonist solabegron. Another treatment combination according to the invention comprises solabegron, and a muscarinic receptor antagonist which results in a synergistic effect on the symptoms associated with OAB.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: March 6, 2018
    Assignee: Velicept Therapeutics, Inc.
    Inventors: Stephen Caltabiano, Eliot Ohlstein, Stewart McCallum
  • Patent number: 9889081
    Abstract: The present invention provides methods and compositions for reducing pigmentation.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: February 13, 2018
    Assignees: The Regents of the University of California, Board Of Regents, The University Of Texas System
    Inventors: Anand Ganesan, Michael A. White, Patrick J. Farmer
  • Patent number: 9877948
    Abstract: A method for preparing a transdermal absorption composition includes mixing rotigotine and an antioxidant at a weight ratio of 1:0.0001 to 0.1. A transdermal therapeutic system includes a substrate and a drug-containing adhesive layer disposed on the substrate and including an antioxidant at a weight ratio of 1:0.0001 to 0.1. The method and system of the present invention suppress the crystallization of rotigotine as well as the generation of related substances, thereby increasing the long-term storage stability of a therapeutic product containing rotigotine or related substances.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: January 30, 2018
    Assignee: SK Chemicals Co., Ltd.
    Inventors: Wonno Youn, Yeo-Jin Park, Hun-Teak Kim
  • Patent number: 9844515
    Abstract: The invention is concerned with a transdermal therapeutic system (TTS) comprising buprenorphine and a method of manufacturing such a TTS. The transdermal therapeutic system is used for the transdermal administration of buprenorphine and analogues thereof. In particular, the invention relates to the use of a transdermal therapeutic system (TTS) for analgesic purposes. The TTS according to the invention comprises a transdermal drug delivery composition comprising buprenorphine and an adhesive component, which is a mixture of a crosslinked and a non-crosslinked acrylic polymer and a penetration enhancer comprising a keto acid.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: December 19, 2017
    Assignee: Hexal AG
    Inventors: Jens Fleschhut, Susanne Feinaeugle, Karin Lauer
  • Patent number: 9833419
    Abstract: Described are transdermal drug delivery systems for the transdermal administration of estrogen, comprising a polymer matrix and estrogen. Methods of making and using such systems also are described.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: December 5, 2017
    Assignee: NOVEN PHARMACEUTICALS, INC.
    Inventor: Juan Mantelle
  • Patent number: 9808609
    Abstract: The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 500,000-1,600,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: November 7, 2017
    Assignee: Nitto Denko Corporation
    Inventors: Masato Nishimura, Yoshihiro Iwao, Katsuhiro Okada, Kensuke Matsuoka
  • Patent number: 9808416
    Abstract: An oral care composition and methods for making and using same are provided. In at least one embodiment, the oral care composition can include ethylcellulose, a binder, a plasticizer, a fluoride compound, a solvent, and fumed silica. In another embodiment, the oral care composition can include ethylcellulose, hydrogenated rosin, and acetyl tributyl citrate.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: November 7, 2017
    Assignee: Colgate-Palmolive Company
    Inventors: Marian Georges, Andre Michelle Morgan, Sarita Vera Mello, Pierre Lambert, Claude Blanvalet
  • Patent number: 9803115
    Abstract: Disclosed is an adhesive hydrogel containing a polymer matrix, water, and a polyhydric alcohol, wherein the polymer matrix contains a copolymer of a monofunctional monomer with a single polymerizable C—C double bond and a polyfunctional monomer with two or more polymerizable C—C double bonds, the monofunctional monomer contains a nonionic (meth)acrylamide-based monomer, and the polyfunctional monomer has a composition formula: ClHmOn, where O is an oxygen atom in an ether bond, l is an integer greater than or equal to 4, m is an integer greater than or equal to 6, and n is an integer greater than or equal to 0.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: October 31, 2017
    Assignee: Sekisui Plastics Co., Ltd.
    Inventors: Takaaki Hatori, Kaori Sato, Takahiko Fujita, Kengo Nakamura
  • Patent number: 9801950
    Abstract: The present invention relates to a liquid formulation of long-acting insulinotropic peptide conjugate, comprising a pharmaceutically effective amount of long-acting insulinotropic peptide conjugate consisting of a physiologically active peptide, insulinotropic peptide, and an immunoglobulin Fc region; and an albumin-free stabilizer, wherein the stabilizer comprises a buffer, a sugar alcohol, a non-ionic surfactant, and an isotonic agent, and a method for preparing the formulation. For the purpose of preventing microbial contamination, a preservative may be added. The liquid formulation of the present invention is free of human serum albumin and other potentially hazardous factors to body, having no risk of viral contamination, and thus can provide excellent storage stability for insulinotropic peptide conjugates at high concentration.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: October 31, 2017
    Assignee: HANMI PHARM. CO., LTD.
    Inventors: Hyun Uk Kim, Hyung Kyu Lim, Sung Hee Hong, Dae Jin Kim, Sung Min Bae, Se Chang Kwon
  • Patent number: 9789005
    Abstract: An antimicrobial medical dressing provides a combination of antimicrobial agents in various concentrations that protect against microorganisms, absorb exudates, and promote healing. The antimicrobial agents may include compositions of ethanol, hydrogen peroxide, and/or ethylenediaminetetraacetic acid.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: October 17, 2017
    Assignee: Hyprotek, Inc.
    Inventors: Patrick O. Tennican, L. Myles Phipps
  • Patent number: 9789060
    Abstract: The present disclosure relates to a carrier for oromucosal, especially sublingual administration of physiologically active substances, especially of medicinal drugs, which consists of at least one elastic layer (1) of polymer nanofibers workable according to the shape of the selected wall of mouth cavity to which it should be applied and in this elastic layer (1) of polymer nanofibers a drug and/or other physiologically active substance are deposited in a releasable manner.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: October 17, 2017
    Assignee: INSTAR TECHNOLOGIES A.S.
    Inventors: Denisa Stranska, Adela Klabanova, Pavel Dolezal, Petr Vrbata, Pavel Berka, Marie Musilova
  • Patent number: 9782516
    Abstract: A therapeutic formulation is described for a drug delivery balloon comprising a therapeutic formulation which includes a therapeutic agent and an adhesion additive. The adhesion additive promotes adhesion of the therapeutic formulation a vessel wall of a subject. A system and a method of manufacturing a system including an expandable member having a working length with the therapeutic formulation disposed along at least a portion of the working length is also provided.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 10, 2017
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Stephen D. Pacetti, John Stankus
  • Patent number: 9775882
    Abstract: Medical devices and methods including polymers having biologically active agents therein are disclosed. The medical devices can be useful as implantable devices such as orthopedic implants.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: October 3, 2017
    Assignee: Medtronic, Inc.
    Inventors: Phillip Edward McDonald, Christopher M. Hobot
  • Patent number: 9763833
    Abstract: Provided are buffered adhesive compositions comprising a high molecular weight non-neutralized polymeric acid and a high molecular weight partially neutralized polymeric acid and products such as wound dressings and ostomy skin barriers incorporating the compositions.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: September 19, 2017
    Assignee: Hollister Incorporated
    Inventors: Michael Gerard Taylor, Richard Iwao Murahata
  • Patent number: 9707189
    Abstract: The problem of the present invention is to provide a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of an acidic drug. A composition for enhancing transdermal absorption of an acidic drug, comprising a polyvalent alcohol having 3-8 carbon atoms, a higher alcohol having 12-20 carbon atoms and an organic amine having 2-9 carbon atoms.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: July 18, 2017
    Assignee: NITTO DENKO CORPORATION
    Inventors: Arimichi Okazaki, Tsuyoshi Mukobata, Sachiko Sakamoto, Akinori Hanatani
  • Patent number: 9707187
    Abstract: The problem of the present invention is to provide a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of a drug, particularly, a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of an acidic drug. A composition for enhancing transdermal absorption of a drug, comprising an unsaturated higher alcohol having 12-20 carbon atoms and a polyvalent alcohol having 3-8 carbon atoms. A composition for enhancing transdermal absorption of a drug, comprising an unsaturated higher alcohol having 12-20 carbon atoms, a polyvalent alcohol having 3-8 carbon atoms and an organic amine having 2-9 carbon atoms.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: July 18, 2017
    Assignee: NITTO DENKO CORPORATION
    Inventors: Arimichi Okazaki, Tsuyoshi Mukobata, Sachiko Sakamoto, Akinori Hanatani
  • Patent number: 9700552
    Abstract: The invention provides transdermal patches comprising an adhesive and a composition comprising naltrexone and either methyl oleate or isopropyl myristate, a kit comprising a plurality of such transdermal patches, a composition comprising naltrexone and methyl oleate, such a composition for use as a medicament, and compositions comprising naltrexone and methyl oleate or isopropyl myristate for use in the treatment of alcoholism or opiate addiction.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: July 11, 2017
    Assignee: Syntropharma Limited
    Inventor: Ludwig Jan Weimann
  • Patent number: 9669042
    Abstract: Disclosed are compositions and formulations comprising glucosamine or a pharmaceutically acceptable salt thereof for use in the treatment of joint conditions and adapted for use in a bath or soak or bath beads, powders, salts, and oils, kits, and methods of treatment using the same. Also disclosed are lozenges, suppositories, patches, and topical creams comprising glucosamine or a pharmaceutically acceptable salt thereof for use in the treatment of joint conditions and methods of treatment using the same. In some embodiments the joint conditions include osteoarthritis.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: June 6, 2017
    Assignee: Vital Medicine, LLC
    Inventors: Anjan Chatterji, Grant Cooper, David Schwartz