Pressure Sensitive Adhesive Means Patents (Class 424/448)
  • Patent number: 11141451
    Abstract: A pharmaceutical composition and a health functional food including an oat extract as an effective ingredient for prevention or treatment of neurodegenerative disease. More specifically, the present invention provides a pharmaceutical composition and a health functional food including an oat extract such as avenanthramide C or a derivative thereof, for example, avenanthramide methyl ester as an effective ingredient for prevention or treatment of Alzheimer's disease.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: October 12, 2021
    Assignees: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY, REPUBLIC OF KOREA (MANAGEMENT: RURAL DEVELOPMENT ADMINISTRATION)
    Inventors: Ji Hoon Jo, Hyung Seok Kim, Yu Young Lee
  • Patent number: 11141452
    Abstract: A compound for treatment of pain comprising a single multivalent/multifunctional ligand with agonist activity at opioid receptors and with antagonist activity at NK-1 receptors, joined by a linker. Also disclosed is a pharmaceutical compound comprising the above compound in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: October 12, 2021
    Assignee: Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Victor J. Hruby, Aswini K. Giri
  • Patent number: 11135204
    Abstract: Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR inhibitors, one or more solvents, one or more gelling agents, and one or more antioxidants. Also disclosed herein are methods to treat skin disorders using such compositions.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: October 5, 2021
    Assignee: Palvella Therapeutics, Inc.
    Inventors: Wesley Harton Kaupinen, Braham Shroot, Simon David Betson, Charles Rodney Greenaway Evans, Marc Barry Brown
  • Patent number: 11117808
    Abstract: Nitric oxide-releasing materials, methods of making nitric oxide-releasing materials, and uses of nitric oxide-releasing materials are provided. The nitric oxide-releasing materials include a mesoporous silica core and an outer surface having a plurality of nitric oxide donors. In an exemplary aspects, the nitric oxide-releasing material includes a mesoporous diatomaceous earth core, and an outer surface having a plurality of S-nitroso-N-acetyl-penicillamine groups covalently attached thereto. Uses of the nitric oxide-releasing materials can include coatings for medical devices such as catheters, grafts, and stents; wound gauzes; acne medications; and antiseptic mouthwashes; among others.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: September 14, 2021
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Hitesh Handa, Marcus Goudie, Jitendra Pant, Bryan Grommersch, Sean Hopkins
  • Patent number: 11083553
    Abstract: Disclosed is an oral care device, comprising: an elongate strip having a major surface; and first and second tabs respectively extending from first and second portions of the major surface. Each of the first and second tabs is movable relative to the strip between a storage position and an operative position. The strip holds an oral care agent at the major surface of the strip. Also disclosed is a stack of the oral care devices located in an airtight package.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: August 10, 2021
    Assignee: Colgate-Palmolive Company
    Inventor: Matthew Lee Kolb
  • Patent number: 11083690
    Abstract: Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: August 10, 2021
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Tokitae LLC
    Inventors: Shiyi Zhang, Andrew Bellinger, Carlo Giovanni Traverso, Robert S. Langer, Dean Liang Glettig, Lowell L. Wood, Jr., Philip A. Eckhoff
  • Patent number: 11033493
    Abstract: An orally administered dosage form that facilitates delivery of an agent locally in the buccal cavity for a sustained period of time includes mucoadhesive particles that are made of at least a mucoadhesive material combined with the agent, and which are dispersed in a disintegrating film. The dosage form is capable of delivering an agent to a patient at the desired oral mucosa site over an extended period of time while reducing patient discomfort or annoyance associated with conventional sustained release mucoadhesive films that must reside on the oral mucosa during the period of sustained release.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: June 15, 2021
    Assignee: Intelgenx Corp.
    Inventors: Rodolphe Obeid, Nadine Paiement, Erick Gonzalez-Labrada
  • Patent number: 11020356
    Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: June 1, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Ryo Tanaka, Hideaki Ohashi, Naruhide Miyoshi, Takito Shima, Naoko Fujita, Yasunari Michinaka
  • Patent number: 11013697
    Abstract: The present invention relates to a transdermal therapeutic system for administration of an active ingredient and a process for the preparation thereof. The transdermal therapeutic system comprises an overtape with two adhesive layers.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: May 25, 2021
    Assignee: Luye Pharma AG
    Inventors: Björn Schurad, Marieke Gosau
  • Patent number: 11004552
    Abstract: A method for creating a multi-antigen patch, comprising providing one or more transdermal patch sheets having a plurality of single dose transdermal patches residing thereon, wherein each one of the plurality of single dose transdermal patches includes an antigen at a particular dilution level disposed within a carrier, removing one or more of the plurality of single dose transdermal patches from the one or more transdermal patch sheets, adhering the one or more of the plurality of single dose transdermal patches to a backing, wherein the backing allows for multiple single dose transdermal patches to be adjacently adhered thereon, and covering the plurality of transdermal patches adhered to the backing with a peelable release liner.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: May 11, 2021
    Assignee: ROCA MEDICAL LTD.
    Inventors: James Strader, Jovan Hutton Pulitzer
  • Patent number: 10980990
    Abstract: Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, composition of matter, and/or user interface adapted for and/or resulting from, and/or a method and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to, controlling delivery of a transdermally-delivered medication, certain embodiments including a flux controller.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: April 20, 2021
    Assignee: N Brereton Medical Technologies, LLC
    Inventor: Neil Brereton Jackson
  • Patent number: 10982032
    Abstract: An object of the present invention is to provide a self-assembly composition for pattern formation, which is capable of forming a favorable phase-separated structure even in the case of forming a large size pattern. In addition, another object of the present invention is to provide a self-assembly composition for pattern formation, which is capable of forming a pattern by a simple process, with no need for preparation of a under layer, etc., upon formation of a fine pattern structure. The present invention relates to a self-assembly composition for pattern formation, which comprises a block copolymer comprising a polymerization unit (a) comprising two or more units consisting of at least one type selected from a glucose unit and a xylose unit, and a polymerization unit (b) comprising two or more units consisting of at least one type selected from an aromatic ring-containing unit, a silicon-containing unit and a metal-containing unit.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: April 20, 2021
    Assignee: OJI HOLDINGS CORPORATION
    Inventor: Kazuyo Morita
  • Patent number: 10953308
    Abstract: An apparatus for hand protection includes a flexible sheet that extends from a first end to a second end of the flexible sheet along a length thereof. Adhesive material is located on one side of the flexible sheet. A backing layer is on the adhesive material. The flexible sheet includes at least one finger opening closer to the first end than to the second end. A method enables a flexible sheet with adhesive material thereon to be applied to a person's hands. Fingers are inserted through one or more finger openings. The backing layer is removed. The flexible sheet is adhered to the person's hand.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: March 23, 2021
    Assignee: WOD Solutions Inc.
    Inventors: Eugene Blazhko, Aleksandr Laznik
  • Patent number: 10940121
    Abstract: A method for producing a gel patch comprising an adhesive mass layer on a backing fabric, comprising a step of applying a composition comprising a physiologically active substance, a water-soluble polymer, glycerin, and water to the backing fabric to form the adhesive mass layer, wherein a loss tangent of the composition in dynamic viscoelasticity measurement at 1 Hz at a time of application to the backing fabric is 0.75 to 1.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: March 9, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiichiro Tsuru, Masayoshi Maki
  • Patent number: 10918635
    Abstract: Pharmaceutical formulations and methods for the topical or transdermal delivery of 1isobutyl-1H-imidazo[4,5-c]-quinolin-4-amine or 1-(2-methylpropyl)-1H-imidazo[4,5 c]quinolin-4-amine, i.e., imiquimod, to treat genital/perianal warts with shorter durations of therapy than currently prescribed for the commercially available for Aldara® 5% imiquimod cream, as now approved by the U.S. Food & Drug Administration (“FDA”), are disclosed and described. More specifically, lower dosage strength imiquimod formulations to deliver an efficacious dose of imiquimod for treating genital/perianal warts with an acceptable safety profile and dosing regimens that are shorter and more convenient for patient use than the dosing regimen currently approved by the U.S. Food & Drug Administration (“FDA”) for Aldara® 5% imiquimod cream to treat genital/perianal warts are also disclosed and described.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: February 16, 2021
    Assignee: MEDICIS PHARMACEUTICAL CORPORATION
    Inventors: Michael T. Nordsiek, Jefferson J. Gregory
  • Patent number: 10919288
    Abstract: In embodiments, the present invention relates to a method of producing a multilayered printed item, comprising: (a) providing a coating of curable composition comprising a polymer powder, at least one plasticizer, and at least one monomer and/or oligomer, onto the substrate or a thereon previously applied layer or coating; (b) heating the curable coating composition to a temperature of about 70-120° C., to provide a gelled curable coating; (c) providing a coating of curable composition comprising a polymer powder, at least one plasticizer, and at least one monomer and/or oligomer, onto the previously applied layer or coating; (d) heating the other curable as above, to provide second gelled curable coating; (e) before crosslinking is performed, the multilayer-coated substrate formed is heated to a temperature of about 130-160° C.; and (f) crosslinking the heated multilayer-coated substrate, by irradiation and/or subjection to heat at a temperature of about 165-190° C.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: February 16, 2021
    Assignee: PROCRAFT DEVELOPMENT BV
    Inventor: Dirk Jan Van Heijningen
  • Patent number: 10912822
    Abstract: Devices for guided tissue regeneration (GTR) include a matrix of chitosan and mutable collagenous tissue (MCT) wherein the chitosan is electrostatically bonded to the MCT to form MCT-chitosan composite material. The MCT can be isolated from invertebrate marine organisms, such as sponges, jellyfish, mollusks and echinoderms. The MCT-chitosan composite material can be formulated as a biofilm, a 3D-sponge, a hydrogel, or as an electrospun nanofiber, or the MCT-chitosan composite material can coat a biomaterial surface. The devices can include wound dressings and tissue sponges, including 3D sponges. Applications include tissue engineering and wound healing, as well as burns and other related guided tissue regeneration applications. MCT and MCT-chitosan composite material, contained in a pharmaceutically acceptable topical carrier, also has cosmeceutical applications, for treating scars, as well as skin discoloration and various pigmentation issues, including melasma/chloasma.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: February 9, 2021
    Assignee: Marine Essence Biosciences Corporation of USA
    Inventors: Danny Qiu, Sergio Madrigal Carballo
  • Patent number: 10905669
    Abstract: The present invention provides for a method of improving the release of non-steroidal anti-inflammatory drugs (NSAIDs) from a plaster or bandage comprising an adhesive layer with a pharmaceutically acceptable NSAID together with heparin or a heparinoid. The invention also provides for methods of reducing muscle hyperalgesia in subjects without spontaneous pain.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: February 2, 2021
    Assignee: ALTERGON S.A.
    Inventors: Valeria Frangione, Arturo Lanzarotti
  • Patent number: 10898450
    Abstract: A transdermal dosing unit may include a first segment having a first pharmaceutical in a first reservoir, a first releasing compound, and a first adhesive component, a second segment removably connected to the first segment, the second segment having a second pharmaceutical in a second reservoir, a second releasing component, and a second adhesive component, and a backing component. The transdermal dosing unit may further include additional segments, and may include a perforated section between each segment. The first adhesive component may have a first adhesion strength, and the second adhesive component may have a second adhesion strength that is either different from or approximately equal to the first adhesion strength. A method of titrating a dose of such a transdermal dosing unit may include applying the transdermal dosing unit to a subject, and removing the first segment while leaving the second segment on the subject.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: January 26, 2021
    Assignee: Clemtech Pharmaceuticals, LLC
    Inventors: David Harrison Clements, IV, Eric D. Clements
  • Patent number: 10894008
    Abstract: Compositions and methods for improving skin health and skin barrier function. Specifically, topical administration of compositions comprising low dose formulations of ambroxol can be used to improve skin barrier function.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: January 19, 2021
    Assignee: NeueRe, LLC
    Inventor: Stephen Anderson
  • Patent number: 10857115
    Abstract: The present invention provides for a method of improving the release of non-steroidal anti-inflammatory drugs (NSAIDs) from a plaster or bandage comprising an adhesive layer with a pharmaceutically acceptable NSAID together with heparin or a heparinoid. The invention also provides for methods of reducing muscle hyperalgesia in subjects without spontaneous pain.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: December 8, 2020
    Assignee: ALTERGON SA
    Inventors: Valeria Frangione, Arturo Lanzarotti
  • Patent number: 10842980
    Abstract: Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, composition of matter, and/or user interface adapted for and/or resulting from, and/or a method and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to, controlling delivery of a transdermally-delivered medication, certain embodiments including a flux controller.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: November 24, 2020
    Assignee: N Brereton Medical Technologies, LLC
    Inventor: Neil Brereton Jackson
  • Patent number: 10821297
    Abstract: A system for delivering energy to an isolated part of a mammalian body includes an electrically powered patch and a self-supporting adhesive film. The patch has a major surface and comprises a matrix of at least one flexible, biocompatible material which is capable of conforming to the isolated body part. The self-supporting adhesive film has a first non-tacky surface arranged and configured for releasable attachment to the patch and a second tacky surface, opposite the first surface, for adhesive attachment to the isolated body part. The releasable attachment between the self-supporting adhesive film and the electrically powered patch has a lower strength than the adhesive attachment between the film and the isolated body part. Thus, during use the electrically powered patch is removable from the self-supporting adhesive film while leaving the self-supporting adhesive film adhered to the isolated body part.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: November 3, 2020
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Curt Binner, Alexandru Paunescu
  • Patent number: 10806705
    Abstract: The present invention provides a patch comprising a backing and an adhesive layer laminated on one side of the backing, wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: October 20, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takashi Yasukochi, Atsushi Sonobe, Satoshi Amano
  • Patent number: 10745594
    Abstract: The invention relates to an adhesive composition comprising at least one latex and at least one polymer composition having a glass transition temperature ranging from ?50° C. to 0° C., said adhesive composition being particularly suitable for bonding flexible surface coverings having a high dimensional variability. The invention also relates to a membrane obtained after drying of the adhesive composition according to the invention, a combination of a flexible surface covering with an adhesive composition according to the invention, a method of application of a flexible surface covering onto a substrate as well as a substrate covered with a peelable adhesive membrane according to the invention.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: August 18, 2020
    Assignee: BOSTIK SA
    Inventors: Jessie Casimiro, Eric Verscheure
  • Patent number: 10729679
    Abstract: A pramipexole transdermal patch for treatment of neurological disorders including Parkinson's disease that may be administered on a daily basis. The pramipexole transdermal patch of the present invention preferably comprises a drug-containing layer that comprises pramipexole or a pharmaceutically acceptable salt thereof at 2% to about 15% by weight of the drug-containing layer and at least two acrylic polymers wherein each polymer may further comprise carboxyl and/or hydroxyl functional groups. The pramipexole transdermal patch of the present invention may further comprise two or more permeation enhancers with combined pramipexole solubility of great than 50 mg/mL.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 4, 2020
    Assignee: Transwell Biotech Co., Ltd.
    Inventors: Catherine Lee, Taijung Wu
  • Patent number: 10729686
    Abstract: The invention provides transdermal patches comprising an adhesive and a composition comprising naltrexone and methyl oleate or isopropyl myristate, a kit comprising a plurality of such transdermal patches, a composition comprising naltrexone and methyl oleate, such a composition for use as a medicament, and compositions comprising naltrexone and methyl oleate or isopropyl myristate for use in the treatment of alcoholism or opiate addiction.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: August 4, 2020
    Assignee: LIBERO PHARMA LIMITED
    Inventor: Ludwig Jan Weimann
  • Patent number: 10722499
    Abstract: Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR inhibitors, one or more solvents, one or more gelling agents, and one or more antioxidants. Also disclosed herein are methods to treat skin disorders using such compositions.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: July 28, 2020
    Assignee: PALVELLA THERAPEUTICS, INC.
    Inventors: Wesley Harton Kaupinen, Braham Shroot, Simon David Betson, Charles Rodney Greenaway Evans, Marc Barry Brown
  • Patent number: 10716763
    Abstract: The present invention provides a patch comprising a backing and an adhesive agent layer laminated on the backing, wherein the adhesive agent layer comprises ropinirole or a pharmaceutically acceptable salt thereof, an organic amine or an acid addition salt thereof, and an adhesive agent.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: July 21, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Naoyuki Uchida, Yasunari Michinaka
  • Patent number: 10688108
    Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: June 23, 2020
    Assignee: Leo Pharma A/S
    Inventors: Marianne Lind, Gritt Rasmussen, Mette Rydahl Sonne, Jens Hansen, Karsten Petersson
  • Patent number: 10661065
    Abstract: Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, composition of matter, and/or user interface adapted for and/or resulting from, and/or a method and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to, controlling delivery of a transdermally-delivered medication, certain embodiments including a flux controller.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: May 26, 2020
    Inventor: Neil Brereton Jackson
  • Patent number: 10653636
    Abstract: A medical active substance patch comprising a matrix of monolayer or multilayer configuration with at least one active substance-containing layer and comprising a backing layer connected with the matrix. The active substance patch is transparent or at least translucent, and in the state of having been applied to the skin of a first person, the patch has a lightness colour value L1 at a place of the skin covered by the patch which is not less than 50% and not more than 200% of a lightness colour value L2, L2 being the lightness value of the region of the skin of the same person which surrounds the applied patch. The same is true of the skin of a second or any other person, provided that for all the persons mentioned L2 is in the range from 5° to 100°, namely from 20° to 90°.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: May 19, 2020
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventor: Stefan Bracht
  • Patent number: 10639486
    Abstract: Implantable medical device (IMD) such as leadless cardiac pacemakers may include a rechargeable power source. In some cases, the IMD may include a plurality of receiving coils that may capture a non-radiative near-field energy and then convert the near-field energy into electrical energy that may be used to recharge the rechargeable power source. Accordingly, since the rechargeable power source does not have to maintain sufficient energy stores in a single charge for the entire expected life of the IMD, the power source itself and thus the IMD, may be made smaller while still meeting device longevity expectations.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: May 5, 2020
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: William J. Linder, Michael J. Kane, Jeffrey E. Stahmann, Jacob M. Ludwig, Brendan Early Koop, Daniel Joseph Landherr, Greg Paul Carpenter, Keith R. Maile
  • Patent number: 10617784
    Abstract: An article having anti-microbial effect is provided. The article includes an occlusive layer; a substrate overlaying the occlusive layer, wherein the substrate having two opposing major surfaces; a metal oxide layer overlaying the substrate, wherein the metal oxide layer comprises a metal oxide and wherein the metal oxide layer comprises less than 40 wt. % non-oxidized metal; and a metal layer overlaying the metal oxide layer.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: April 14, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Ta-Hua Yu, Döne Demirgöz, Junkang J. Liu, Badri Veeraraghavan, Narina Y. Stepanova
  • Patent number: 10610526
    Abstract: A composition suitable for use in nicotine replacement therapy products includes a nicotine product that includes a synthetic nicotine that is substantially free of one or more contaminants and/or impurities normally associated with tobacco-derived nicotine. For example, the synthetic nicotine is substantially free of one or more of nicotine-1?-N-oxide, nicotyrine, nornicotyrine, 2?,3-bipyridyl, cotinine, anabasine, and/or anatabine. The composition further comprises one or more pharmaceutically acceptable excipients, additives and/or carriers. The nicotine replacement therapy products may include any number of such products, including transdermal nicotine delivery patches, nicotine gums, synthetic chewing tobacco, synthetic snuff, and synthetic strips (e.g., dissolvable synthetic tobacco). Additionally, a method of treating nicotine addiction includes administering a nicotine replacement composition, e.g., via a nicotine replacement therapy product, to a user.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: April 7, 2020
    Assignee: NEXT GENERATION LABS, LLC
    Inventor: Michael Arnold
  • Patent number: 10590284
    Abstract: A process is described herein for applying antimicrobials to substrates to prevent the growth of biological agents. An antimicrobial-binder mixture is provided. The binder comprises guar gum, ammonium sulfate, urea, and methyl acryloid. The antimicrobial is an organo silane quarternary amine antimicrobial. The antimicrobial-binder mixture is ionized to comprise negatively charged particles. The antimicrobial-binder mixture is aerosolized to form fog. The fog is administered to the surface and dried.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: March 17, 2020
    Assignee: SANIT TECHNOLOGIES LLC
    Inventor: Joseph Giovanniello
  • Patent number: 10583043
    Abstract: The present invention relates to a backing having a three-layer structure prepared by sticking together an inner fiber layer for holding a pasty preparation, a film layer having through-holes, and an air-permeable outer fiber layer which prevents leaking out of the pasty preparation or a liquid component exuded from the pasty preparation, and also relates to an aqueous patch using the backing which can be applied for a long time.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: March 10, 2020
    Assignees: TEIKOKU SEIYAKU CO., LTD., TOYOBO CO., LTD.
    Inventors: Sadanobu Shirai, Masahiro Inazuki, Miho Ishigure, Hideo Isoda, Hiroyuki Sakamoto, Takashi Koida, Hiroyasu Sakaguchi
  • Patent number: 10582915
    Abstract: The present disclosure relates to a film for oral hemostasis and wound protection and, more particularly, to a film for oral hemostasis and wound protection which, being attached to a wound area in an oral cavity, delays or prevents microbleeds and controls medicinal component release. The film provided by the present disclosure is capable of including a polyol, an alcohol and a biodegradable polymer in the state of partial swelling, thereby locally absorbing blood or pus or arresting hemorrhage. Moreover, due to its high elongation ratio, the film provided by the present disclosure is capable of maintaining its adhesive force even when having blood, saliva and pus absorbed inside an oral cavity and conveniently deforming according to the shape of a seriously corrugated local area, which causes only slight foreign body sensation even after a long period of time of attachment on to the local area.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: March 10, 2020
    Assignee: TBM Company
    Inventor: Seiyeong Yun
  • Patent number: 10576043
    Abstract: Provided herein is a water- and sweat-resistant transdermal drug delivery system for application to the skin of a mammal that comprises a patch having a diameter between 1 and 8 cm in length and a surface area between 4 and 8 cm2. Also provided are methods of producing the transdermal drug delivery system and methods of treatment comprising the use of the transdermal drug delivery system.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: March 3, 2020
    Assignee: Avro Life Sciences, Inc.
    Inventors: Shakir Lakhani, Keean Sarani
  • Patent number: 10568845
    Abstract: The invention relates to a transdermal therapeutic system (TTS), comprising a backing layer, which is permeable to the active ingredient, at least one matrix layer, comprising fentanyl or an active agent analogous to fentanyl, based on polyacrylate and a protective layer to be removed before usage, characterized in that the polyacrylate polymer is self-adhesive, free of carboxyl groups, has a saturation solubility for fentanyl of 3 to 20 wt. %, preferably of 4 to 12 and particularly of 5 to 10 wt. % and the layers contain at least 80% of the included active ingredient in a molecularly-dispersed, dissolved form.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: February 25, 2020
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: Walter Müller, Thomas Hille
  • Patent number: 10525246
    Abstract: A system and method of using a high-aspect ratio microdevice for treating, preventing or ameliorating a medical condition is provided.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: January 7, 2020
    Assignee: NANOMED SKINCARE, INC.
    Inventor: Bai Xu
  • Patent number: 10500387
    Abstract: A microneedle unit including a microneedle having a first surface and a second surface opposite to the first surface, the microneedle being flexible and having one or more projections on the first surface, and a support member connected to the second surface of the microneedle such that the support member supports the microneedle. The support member includes an adhesive portion and a rigid portion connected to the adhesive portion, the adhesive portion is adhesive to skin and extends outside of the second surface in plan view of the second surface, and the rigid portion includes a rigid plate which is more rigid than the adhesive portion and the microneedle.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: December 10, 2019
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventors: Hiroyuki Kato, Hisami Ueno
  • Patent number: 10493027
    Abstract: A kit for mucosally administering a metastable supersaturated solution of a pharmaceutical active agent to a human patient includes a first compartment comprising a first composition comprising a pharmaceutical active agent in solution at or below equilibrium solubility, and a second composition comprising an acidic buffer. The first and second compartments maintain separation of the first and second compositions during storage, and allow for mixing of the first and second compositions to form a supersaturated solution above equilibrium solubility of the pharmaceutical active agent for immediate mucosal administration to a human patient. In one embodiment, the second composition comprises an acidic buffer and the supersaturated solution has an acidic pH. Alternatively, the second composition comprises a basic buffer and the supersaturated solution has a basic pH.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: December 3, 2019
    Assignee: MUCODEL PHARMA LLC
    Inventor: Madhu Hariharan
  • Patent number: 10485792
    Abstract: The present invention discloses a method of treating a head and neck cancer or preventing the development of pre-malignant lesions to this cancer, by administering locally to the oral cavity, a sustained release drug delivery system comprising a drug for the treatment of this cancer or for the prevention of said lesions, and at least one polymer, such that said system is attached to a surface in the oral cavity and remains attached thereto for at least 1 hour, accompanied by release of the drug and maintaining an effective therapeutic concentration thereof in the cavity, for at least 1 hour. Further are disclosed a sustained release drug delivery system and a liquid precursor varnish composition to this system.
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: November 26, 2019
    Assignees: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Michael Friedman, Rakefet Czernimski, Silvio Gutkind, Doron Steinberg, Irith Gati, Zakhar Nudelman
  • Patent number: 10485893
    Abstract: This disclosure provides for an antimicrobial pressure sensitive adhesive composition that includes a sequestered peroxide source and devices that incorporate such a composition.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: November 26, 2019
    Assignee: Sarasota Medical Products, Inc.
    Inventor: Walter F. Leise, III
  • Patent number: 10463737
    Abstract: Silicone acrylate copolymer composition, namely, silicone resin-acrylate copolymers and methods of preparing the same. The silicone acrylate composition may include a silicone resin coupled with an acrylate polymer via a linking group. The silicone acrylate composition may be formed by preparing an acrylate or a (meth)acrylate functional resin and carrying out acrylate polymerization in the presence of a functionalized resin. A silane-functional acrylate polymer may be prepared, followed by a reaction to couple a resin to the silane-functional acrylate polymer. The resulting copolymer may then be used as desired, e.g., added to a silicone and acrylate mixture to create a non-separating blend.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: November 5, 2019
    Assignee: DOW CORNING CORPORATION
    Inventors: Robert O Huber, Gary Lee Loubert, Gerald K Schalau, II, Simon Toth
  • Patent number: 10457772
    Abstract: The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: October 29, 2019
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Willy Chin, Jeannette M. Garcia, James L. Hedrick, Eunice Leong Jiayu, Shrinivas Venkataraman, Zhi Xiang Voo, Rudy J. Wojtecki, Yi Yan Yang
  • Patent number: 10456498
    Abstract: Adhesive compositions exhibiting antimicrobial properties, good stability, long shelf lives and enhanced release of antimicrobial agents are described. In certain versions, the compositions also exhibit relatively high fluid handling capacities. The adhesive compositions inhibit microbial growth by more than 2 log after 24 hours contact and particularly more than 3.5 log after 6 hours contact. Also described are various medical articles using such adhesives and related methods.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: October 29, 2019
    Assignee: Avery Dennison Corporation
    Inventor: Anne M. Wibaux
  • Patent number: 10406114
    Abstract: A method for producing an antibiotic-loaded transdermal patch including preparing a polymeric adhesive solution by dissolving a polymeric mixture in a solvent, preparing a plurality of antibiotic-loaded solid lipid nanoparticles (SLNs), forming a patch formulation by mixing the plurality of antibiotic-loaded SLNs and the polymeric adhesive solution, and forming a layer of the patch formulation on a substrate.
    Type: Grant
    Filed: June 9, 2018
    Date of Patent: September 10, 2019
    Inventors: Masoumeh Nasrollahzadeh Abyazani, Fariba Ganji, Seyed Mojtaba Taghizadeh, Ebrahim Vasheghani Farahani
  • Patent number: 10399111
    Abstract: A film is uniformly coated with a coating solution. The following formula is satisfied: 0<a×c/b<113 where (i) a is a diameter (mm) of a gravure roll, (ii) b is a ratio of a circumferential velocity of the gravure roll to a conveyance speed at which the film is conveyed, and (iii) c is a volume (mL/m2) of recesses of the gravure roll, which volume is measured per unit area of a circumferential surface of the gravure roll.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: September 3, 2019
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Ryutaro Shiba, Yasutoshi Minemoto