Pressure Sensitive Adhesive Means Patents (Class 424/448)
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Patent number: 9198876Abstract: Dosing regimen for transdermal delivery of hormones comprising a 28 day treatment cycle with a fixed treatment interval and a fixed rest interval.Type: GrantFiled: October 7, 2009Date of Patent: December 1, 2015Assignee: Agile Therapeutics, Inc.Inventors: Thomas M. Rossi, Marie Foegh, Agis Kydonieus
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Patent number: 9198920Abstract: Dosing regimen for transdermal delivery of hormones comprising a 28 day treatment cycle with a fixed treatment interval and a fixed rest interval.Type: GrantFiled: March 25, 2010Date of Patent: December 1, 2015Assignee: Agile Therapeutics, Inc.Inventors: Thomas M. Rossi, Marie Foegh, Agis Kydonieus
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Patent number: 9198919Abstract: Dosing regimen for transdermal delivery of hormones comprising a variable treatment cycle and a variable rest interval.Type: GrantFiled: October 7, 2009Date of Patent: December 1, 2015Assignee: Agile Therapeutics, Inc.Inventors: Thomas M. Rossi, Marie Foegh, Agis Kydonieus
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Patent number: 9193852Abstract: The present invention is directed to an aerated composition comprising, in a physiologically acceptable medium, an oily phase dispersed in an aqueous phase, characterized in that it contains air or inert gas in a sufficient amount to have a relative density ranging from about 0.2 to about 0.9 (g/cm3) measured at a temperature of approximately 25° C. and at atmospheric pressure, and in that it comprises at least one modified starch, at least one emulsifier, and at least one oil-dispersible structuring agent.Type: GrantFiled: December 27, 2013Date of Patent: November 24, 2015Inventors: Andrew Goldberg, Angelike Galdi, Raul M. Diaz
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Patent number: 9192614Abstract: Dosing regimen for transdermal delivery of hormones comprising a monthly treatment cycle with a fixed treatment interval and a variable rest interval.Type: GrantFiled: October 7, 2009Date of Patent: November 24, 2015Assignee: Agile Therapeutics, Inc.Inventors: Thomas M. Rossi, Marie Foegh, Agis Kydonieus
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Patent number: 9168251Abstract: The present disclosure relates to a method of providing prolonged analgesia to a mammal in need thereof. Specifically, the current disclosure is directed to a method of treating pain in a mammal for a prolonged period of time using a single high dose of a buprenorphine formulation.Type: GrantFiled: September 2, 2011Date of Patent: October 27, 2015Assignee: Zoetis Belgium S.AInventors: Rachel A. Richardson, Carmela H. Luangdilok, Luk Chiu Li
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Patent number: 9155712Abstract: A transdermal drug delivery system for the topical application of one or more active agents contained in one or more polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric backing layer which can control the delivery rate and profile of the transdermal drug delivery system by adjusting the moisture vapor transmission rate of the polymeric backing layer.Type: GrantFiled: July 21, 2014Date of Patent: October 13, 2015Assignee: NOVEN PHARMACEUTICALS, INC.Inventors: David Kanios, Juan A. Mantelle, Viet Nguyen
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Patent number: 9132114Abstract: A composition to treat wounds comprising non-geniculate marine coral algae in combination with one or more sugars.Type: GrantFiled: July 30, 2007Date of Patent: September 15, 2015Inventor: David M. Dixon
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Patent number: 9119861Abstract: An adhesive patch is provided in which piroxicam is formulated as a non-steroidal anti-inflammatory analgesic. In particular, provided is a piroxicam-containing transdermally absorbable adhesive patch in which an absorption promoter to piroxicam is formulated to achieve high anti-inflammatory and analgesic effects without inhibiting releasing of these drugs. The piroxicam-containing transdermally absorbable adhesive patch contains piroxicam as a medicinal component and oxybuprocaine or a pharmaceutically acceptable salt thereof as an absorption promoter. In the piroxicam-containing transdermally absorbable adhesive patch, the content of piroxicam is from 0.1% to 5% by weight to the total weight of a drug-containing plaster and the content of oxybuprocaine or the pharmaceutically acceptable salt thereof is from 1% to 30% by weight to the total weight of the drug-containing plaster.Type: GrantFiled: December 14, 2010Date of Patent: September 1, 2015Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Akiko Katayama, Katsuyuki Inoo
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Patent number: 9101683Abstract: A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.Type: GrantFiled: November 17, 2014Date of Patent: August 11, 2015Assignee: Adhezion Biomedical, LLCInventors: Sheng Zhang, Rafael Ruiz, Sr.
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Patent number: 9089527Abstract: The invention relates to a transdermal therapeutic system which comprises a back layer that is impermeable to the active substance, and a peelable protective layer that is impermeable to the active substance and at least one matrix layer consisting of polysiloxanes and/or polysiloxane derivatives and containing micro-reservoirs. Said micro-reservoirs contain at least one ion pair from a pharmacologically active substance and an additive and either the active substance is nucleophilic and the additive is electrophilic or the active substance is electrophilic and the additive is nucleophilic.Type: GrantFiled: November 16, 2007Date of Patent: July 28, 2015Assignee: LTS Lohmann Therapie-Systeme AGInventors: Thomas Hille, Michael Horstmann, Walter Mueller
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Patent number: 9005653Abstract: The present invention relates to a patch comprising a drug-containing layer with low content of hormones, such as gestodene, and optionally an estrogen (e.g. ethinyl estradiol). Upon administering the patch to a woman, plasma levels of at least 1.0 ng/ml of Gestodene is achieved at steady state conditions without the need of incorporating penetration enhancers or permeation enhancers in the drug-containing layer. Satisfactorily plasma levels of the hormones is also achieved throughout a period of at least 1 week, making the patch applicable for being used in female contraception with the concept of administering the patch ones weekly.Type: GrantFiled: December 27, 2013Date of Patent: April 14, 2015Assignee: Bayer Intellectual Property GmbHInventors: Thomas Langguth, Stefan Bracht, Michael Dittgen, Petra Huber, Dirk Schenk
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Patent number: 9005174Abstract: The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part.Type: GrantFiled: February 23, 2011Date of Patent: April 14, 2015Assignee: Nitto Denko CorporationInventors: Yoshihiro Iwao, Kensuke Matsuoka, Kazuhiro Aoyagi
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Patent number: 8999379Abstract: A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.Type: GrantFiled: February 27, 2014Date of Patent: April 7, 2015Assignee: ALZA CorporationInventor: Robert M. Gale
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Patent number: 8999378Abstract: The present invention provides porous electroactive hydrogels, the deformation angle of which is controlled by electroactuation, and methods for preparing and using such hydrogels.Type: GrantFiled: September 24, 2009Date of Patent: April 7, 2015Assignee: President and Fellows of Harvard CollegeInventors: Kevin Kit Parker, Megan O'Grady
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Patent number: 8968772Abstract: A water-soluble pressure sensitive adhesive comprises a homogeneous blend comprising (a) a polymer selected from the group consisting of N-vinyl caprolactam homopolymers, N-vinyl pyrrolidone copolymers, and mixtures thereof and (b) a non-volatile plasticizer comprising a monohydric or polyhydric alcohol having hydrophilic-lipophilic balance of about 2 to about 10. The N-vinyl pyrrolidone copolymers comprise about 60% or less by weight N-vinyl pyrrolidone.Type: GrantFiled: January 30, 2013Date of Patent: March 3, 2015Assignee: 3M Innovative Properties CompanyInventor: Steven S. Kantner
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Patent number: 8962013Abstract: The UV-stable solid transdermal therapeutic system (TTS) with UV absorber for photosensitive active pharmaceutical ingredients has a backing layer (1), at least one active ingredient-containing matrix (2), and a detachable protective film (3). Optionally an adhesive layer (4) and a separating layer (5) are introduced between the backing layer (1) and the at least one active ingredient-containing matrix (2). At least one hydroxyphenyltriazine compound acting as UV absorber is embedded in the backing layer (1), in the active ingredient-containing matrix (2), or in the adhesive layer (4). The TTS according to the invention achieves high stability at low concentrations of UV absorber, preferably 0.5 to 3% (m/m), so as to reduce or avoid skin irritation.Type: GrantFiled: May 2, 2006Date of Patent: February 24, 2015Assignee: Bayer Intellectual Property GmbHInventors: Thomas Langguth, Stefan Bracht
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Patent number: 8962012Abstract: The present invention is directed to a nonaqueous pressure-sensitive adhesive that may be used in medicinal tape preparations for percutaneous absorption. The adhesive may comprise a copolymer obtained by copolymerization of a (meth)acrylic monomer having an acetoacetyl group in the molecule and one or more monomers from among other (meth)acrylic monomers without acetoacetyl groups and copolymerizable vinyl monomers, in a nonaqueous solvent. Suitable (meth)acrylic monomers having an acetoacetyl group in the molecule are acetoacetoxyalkyl methacrylates, and especially 2-acetoacetoxyethyl methacrylate. The pressure-sensitive adhesive of the invention uses no polyamine derivatives, isocyanate compounds, polyvalent metal chelate compounds, etc., as crosslinking agents, and therefore toxicity is not a concern and skin is not irritated. A medicinal tape preparation for percutaneous absorption of the invention has superior adhesive strength and cohesive strength, and is highly safe with low skin irritation.Type: GrantFiled: January 25, 2013Date of Patent: February 24, 2015Assignee: Nipro Patch Co., Ltd.Inventors: Naohisa Kawamura, Hidenori Sawada, Takayuki Kobayashi
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Patent number: 8956644Abstract: Disclosed are bupivacaine transdermal delivery systems, and related methods.Type: GrantFiled: November 16, 2012Date of Patent: February 17, 2015Assignee: Durect CorporationInventors: Su II Yum, Sung Yun Kwon, Xiaoping Song, James E. Brown
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Publication number: 20150037393Abstract: Adhesive patches for protecting skin imperfections such as age spots, from discoloring and/or darkening during sunless tanning are provided herein. The adhesive patches are sized and shaped to fully or partially cover the skin imperfections during application of a sunless tanning product such to provide a user with uniform color development over the entire skin, and, in some embodiments, to allow for the skin imperfection to appear less visible.Type: ApplicationFiled: August 20, 2013Publication date: February 5, 2015Inventors: Peter Robert Millman, Sydney Skae Millman
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Patent number: 8932625Abstract: An adhesive patch comprising a substrate and a pressure-sensitive adhesive base, wherein the pressure-sensitive adhesive base comprises a rubbery polymer having double bonds in the main chain and a nonsteroidal anti-inflammatory analgesic and contains a UVA screening agent and/or UVB screening agent as a stabilizer for the rubbery polymer. The adhesive patch is excellent in the stability of the pressure-sensitive adhesive base and in drug infiltration into the skin.Type: GrantFiled: December 24, 2004Date of Patent: January 13, 2015Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Yoshiaki Hashimoto, Yasunori Takada, Miyuki Shinmura, Shigeo Suzuki, Kiyomi Tsuruda, Koichi Ikesue
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Patent number: 8920867Abstract: The present disclosure relates to self-supporting films for delivery of a therapeutic agent containing at least one hydrophobic polymer and at least one therapeutic agent. Methods of forming the self-supporting films are also disclosed.Type: GrantFiled: September 22, 2011Date of Patent: December 30, 2014Assignee: Covidien LPInventors: Joshua Stopek, Garrett Ebersole, Amin Elachchabi, Daniel Broom
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Publication number: 20140378917Abstract: The present invention provides transdermal therapeutic systems for dispensing a pharmaceutical product, in particular a pharmaceutical product with a low tendency to spontaneously crystallize. The matrix layer or at least one of the matrix layers in said systems contains a silicone hot-melt adhesive, a pharmaceutical product, and particles made of crosslinked polyvinylpyrrolidone. The invention also relates to a method for producing said transdermal therapeutic systems.Type: ApplicationFiled: December 28, 2012Publication date: December 25, 2014Inventors: Horst Dzekan, Hans-Rainer Hoffmann, Michael Horstmann, Walter Mueller, Sandra Wiedersberg
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Publication number: 20140370076Abstract: The present invention provides a transdermal drug delivery system comprising donepezil or its pharmaceutically acceptable salt and method of making the same.Type: ApplicationFiled: March 12, 2014Publication date: December 18, 2014Inventors: Hoo-Kyun Choi, Myung-Kwan Chun
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Publication number: 20140370077Abstract: The present invention provides a transdermal drug delivery system comprising fentanyl or its pharmaceutically acceptable salt and method of making the same.Type: ApplicationFiled: March 12, 2014Publication date: December 18, 2014Inventors: Hoo-Kyun Choi, Je Phil Ryoo
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Patent number: 8911772Abstract: The invention relates to laminate segments equipped or coated with an adhesive matrix, particularly transdermal therapeutic systems having formulations strongly tending to leak adhesive. The inventive laminate segments include a matrix, with or without a back layer, a protective layer on the adhesive side of the matrix, provided with a cut as a peel-off aid, and a cover film partially coated with adhesive, applied to the protective film, which overlaps the cut in the protective film using the adhesive-free part thereof. The cover film prevents a leakage of the adhesive through the cut, and therefore a gluing together of the laminate segments to the packaging material thereof, without having an adverse effect on the function of the cut as a peel-off aid. Such laminate segments can be produced without the use of any intermediate carriers.Type: GrantFiled: May 27, 2008Date of Patent: December 16, 2014Assignee: LTS Lohmann Therapie-Systeme AGInventors: Hans-Dieter Sahm, Heinrich Thoeing, Wolfgang Laux
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Publication number: 20140363487Abstract: The invention relates to transdermal therapeutic system for the transdermal administration of buprenorphine, comprising a buprenorphine-containing self-adhesive layer structure comprising A) a bupreno?hine-impermeable backing layer, and B) a buprenorphine-containing pressure-sensitive adhesive layer on said buprenorphine-impermeable backing layer, the adhesive layer comprising a) at least one polymer-based pressure-sensitive adhesive, b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof, and c) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid and linolenic acid, levulinic acid and mixtures thereof, in an amount sufficient so that said analgesically effective amount of buprenorphine is solubilized therein to form a mixture, and the carboxylic acid buprenorphine mixture forms dispersed deposits in the said pressure-sensitive adhesive, wherein said buprenorphine-containing pressure-sensitive adhesive layer is the skin contact laType: ApplicationFiled: December 12, 2012Publication date: December 11, 2014Inventors: Thomas Hille, Gabriel Wauer, Kevin John Smith, Helen Elizabeth Johnson, Gillian Elizabeth Mundin
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Publication number: 20140363488Abstract: A method of treating Herpes Labialis includes assembling a patch having hydrocolloid particles added to a layer of adhesive to so configure the patch to have a limited absorption of moisture into the patch combined with a permeability of moisture through and out of the patch. The method additionally includes providing the patch to the user and having the user apply the patch to the user's face in treating the Herpes Labialis, and configuring the patch to be less visible when applied to the user's face than a cream is visible when applied to the user's face.Type: ApplicationFiled: August 25, 2014Publication date: December 11, 2014Inventors: Grazyna Hansen, Anders Christian Nielsen
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Publication number: 20140356412Abstract: [Problem] If lidocaine is composed of non-aqueous patch, the adhesive power of the preparation tends to get lower, as the composition amount of lidocaine is higher. It is popular to solve lidocaine in dissolving agent in order to compose lidocaine in patch and release effective amount into skin. However, if the amount of dissolving agent gets higher, the adhesive power gets extremely lower, so that an long-time attachment is difficult. [Solution] A non-aqueous patch comprising lidocaine and/or its reactant, and a dissolving agent which are contained in a base of plaster, the plaster being hold by a support, of which strength of 50% stretched to longitudinal direction is less than 2,000 g/50 mm and of biaxially-oriented stretch cloth.Type: ApplicationFiled: September 27, 2011Publication date: December 4, 2014Applicants: OISHI KOSEIDO CO., LTD., ITOCHU CHEMICAL FRONTIER CORPORATIONInventors: Tatsuya Mori, Naoyuki Saida
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Patent number: 8900626Abstract: A transdermal drug delivery system comprising a steroid as an active agent, wherein the steroid may be clobetasol propionate, betamethasone dipropionate, amcinonide, or loteprednol etabonate. The transdermal drug delivery system also comprises a pressure-sensitive adhesive layer and a support, wherein the steroid is present in the pressure-sensitive adhesive layer, and wherein the pressure-sensitive adhesive layer is provided on a support. The transdermal drug delivery system may be applied onto the eyelid of a patient in need thereof, in order to treat a disease of the eyelid, such as chalazion, blepharitis or meibomian gland dysfunction.Type: GrantFiled: June 20, 2011Date of Patent: December 2, 2014Assignee: Senju USA, Inc.Inventors: Takahiro Ogawa, Akiharu Isowaki
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Patent number: 8894986Abstract: A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.Type: GrantFiled: August 9, 2011Date of Patent: November 25, 2014Assignee: Adhezion Biomedical, LLCInventors: Sheng Zhang, Rafael Ruiz, Sr.
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Patent number: 8883196Abstract: A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.Type: GrantFiled: November 15, 2013Date of Patent: November 11, 2014Assignee: Agile Therapeutics, Inc.Inventor: Te-Yen Chien
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Patent number: 8877235Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: a step A of obtaining an adhesive agent layer composition comprising oxybutynin hydrochloride as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, a sterol, an organic acid, and a tackifier; a step B of heating the adhesive agent layer composition at a temperature in a range from 55 to 70° C. for 1 to 24 hours; and a step C of cooling the heated adhesive agent layer composition to a temperature lower than room temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.Type: GrantFiled: June 21, 2013Date of Patent: November 4, 2014Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Kazunosuke Aida, Terumitsu Kaiho, Tetsurou Tateishi, Nobuo Tsutsumi
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Patent number: 8871249Abstract: Provided is a medicated patch containing a medicinal agent, an adhesive base material and a tackifier, where the medicinal agent is varenicline or a pharmaceutically acceptable salt thereof, the adhesive base material is a rubbery adhesive base material and the tackifier is a rosin-based tackifier selected from the group consisting of rosin, rosin derivatives and hydrogenated products of the foregoing, or a non-rosin-based tackifier selected from the group consisting of aliphatic hydrocarbon resins and alicyclic hydrocarbon resins, and when a non-rosin-based tackifier is added as the tackifier, a solubilizer for the medicinal agent is further added, the solubilizer containing an alcohol-based solubilizer having at least a solubility parameter of 20-35.Type: GrantFiled: February 9, 2009Date of Patent: October 28, 2014Assignee: Hisamitso Pharmaceutical Co., Inc.Inventors: Naoki Yamamoto, Kumi Morimoto, Akio Takeuchi, Kenji Ishigaki
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Patent number: 8865150Abstract: The present invention relates to pH-sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules of interest, namely active pharmaceuticals. The gels comprise a pharmaceutically acceptable pH-sensitive polymer that responds to a lowering of pH by precipitating into films when in contact with the skin or mucosal surface. The films also comprise an adhesive polymer that allows the film to remain in contact with the tissue for an extended period of time. The wax-film composites comprise a bi-layer film having both the said pH-sensitive mucoadhesive layer to promote strong adherence to the skin and mucosal surfaces as well as a specially bonded wax layer intended to extend the adherence of the film to tissues for a prolonged period of time.Type: GrantFiled: February 7, 2002Date of Patent: October 21, 2014Assignee: University of Kentucky Research FoundationInventors: Russell Mumper, Michael Jay
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Patent number: 8865207Abstract: A blend of at least two polymers in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin.Type: GrantFiled: December 14, 2012Date of Patent: October 21, 2014Assignee: Noven Pharmaceuticals, Inc.Inventors: David Kanios, Rod Hartwig
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Publication number: 20140308338Abstract: A dressing for applying to the skin is characterized in that the adhesive mass is applied discontinuously in a strip or wave and contains an active substance.Type: ApplicationFiled: August 29, 2012Publication date: October 16, 2014Applicant: BEIERSDORF AGInventors: Jens Nierle, Karl-Heinz Woeller, Maxi Zier, Gerd Mueller
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Patent number: 8852628Abstract: Disclosed is a transdermal composition for delivery of diclofenac comprising the use of a pharmaceutically acceptable acid or salt form in an admixture with a pharmaceutically acceptable adhesive matrix carrier. In a preferred embodiment, diclofenac is present as the free acid and potassium salt form in the adhesive matrix composition together with a dual permeation enhancer. The adhesive matrix composition is applied in a method of substantially increasing drug delivery for 24 or more hours.Type: GrantFiled: September 14, 2012Date of Patent: October 7, 2014Assignee: Noven Pharmaceuticals, Inc.Inventors: David Houze, Samara Hantman
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Patent number: 8846093Abstract: Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.Type: GrantFiled: May 4, 2011Date of Patent: September 30, 2014Assignee: Mylan Technologies, Inc.Inventors: Sharad K. Govil, Ludwig J. Weimann
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Patent number: 8840922Abstract: Provided is a donepezil-containing transdermal absorption formulation that can sustainably administer donepezil for a long period of time, and can provide both a rapid increase in the blood level of donepezil and donepezil sustained release properties. The donepezil-containing transdermal absorption formulation is a transdermal absorption formulation produced by dissolving donepezil, which is the active ingredient, in an adhesive patch base that contains a hydrophobic polymer and an absorption promoter. The absorption promoter is one kind or two or more kinds selected from lauryl alcohol, triethyl citrate, isopropyl myristate, cetyl lactate, oleyl alcohol, sorbitan monooleate, polyethylene glycol monostearate, lauromacrogol, N-methyl-2-pyrrolidone, and triacetin.Type: GrantFiled: October 18, 2010Date of Patent: September 23, 2014Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Satoshi Kawakami, Masahiro Yamaji
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Publication number: 20140271798Abstract: A topical copper ion treatment in basic form comprises a copper ion-containing solution composed of a biocompatible solution containing copper ions obtained by leaching of the copper ions from copper metal into the solution. The copper ion-containing solution can be combined with various carriers to form various forms of the copper ion treatment including creams, gels, lotions, foams, pastes, tampons, solutions, suppositories, body wipes, wound dressings, skin patches, and suture material. A method of making the copper ion-containing solution involves placing solid copper metal in a quantity of a biocompatible solution and maintaining the solution at a specified temperature for a predetermined period of time during which copper ions leach from the copper metal into the solution, and thereafter separating the solution from the solid copper metal.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Inventors: Chun Lim Abbott, Dominic C. Abbott
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Patent number: 8821916Abstract: A medical dressing comprising a complex of silver and being capable of releasing antimicrobial silver ion activity, said complex comprising silver and a transition element of Group IV of the periodic system of elements enables a controlled release of silver ion activity to a wound bed.Type: GrantFiled: January 4, 2008Date of Patent: September 2, 2014Assignee: Coloplast A/SInventor: Brian Nielsen
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Patent number: 8821920Abstract: The invention relates to a topical patch comprising a therapeutic compound-impermeable backing layer, a self-adhesive matrix based on polysiloxanes and containing capsaicin or a therapeutic compound analogous to capsaicin, and a protective film to be removed before use, in which the matrix contains liquid microreservoirs based on an amphiphilic solvent, in which the therapeutic compound is present in completely dissolved form and the concentration of the therapeutic compound in the microreservoir droplets is below the saturation concentration. The invention furthermore relates to a process for its production and its use in the treatment of neuropathic pain.Type: GrantFiled: April 12, 2004Date of Patent: September 2, 2014Assignee: LTS Lohmann Therapie Systeme AGInventor: Walter Müller
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Publication number: 20140242150Abstract: The present invention discloses the use of certain compounds as therapeutic agents, and in particular as analgesics and anti-inflammatory agents. Such compounds include, for example, certain diterpene monoglycosides and diterpene diglycosides. The compounds of the present invention may be synthesized or isolated from the fruit of the genus Capsicum, and in particular may be isolated from sweet bell peppers (C. annuum). Pharmaceutically-acceptable salts, enantiomers, diasteriomers, racemic mixtures, enantomerically-enriched mixtures, solvates, and prodrug s of such compounds are also disclosed. Pharmaceutical compositions and methods of using such compounds, including pharmaceutical compositions and methods of using such compounds in combination with one or more active ingredients, are also disclosed.Type: ApplicationFiled: May 7, 2014Publication date: August 28, 2014Applicant: BMB PATENT HOLDING CORPORATIONInventor: Barry Miles Belgorod
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Publication number: 20140242151Abstract: The present invention provides an adhesive skin patch that permits excellent and prolonged percutaneous absorption of tulobuterol and that can be stably applied to the skin for a long period of time with less skin irritation. The adhesive skin patch comprises a base material and a medicated layer provided on one surface of the base material. The medicated layer contains 1 to 30% by weight of a resolvent, 40 to 98% by weight of a pressure-sensitive adhesive, and tulobuterol. The resolvent contains an aliphatic alcohol having a branched-chain structure or a double bond in its C8 to C30 carbon chain. The pressure-sensitive adhesive is a copolymer obtained by copolymerizing monomers containing 70% by weight or more of an alkyl(meth)acrylate whose alkyl group has 6 to 20 carbon atoms.Type: ApplicationFiled: May 7, 2014Publication date: August 28, 2014Applicant: Sekisui Chemical Co., Ltd.Inventors: Hiroko UDAGAWA, Toshikazu KOMODA, Masaru HAMABE
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Patent number: 8818655Abstract: An electronic transmission range selection system of a vehicle includes first and second input devices and first and second modules. The first input device is user actuatable to request operation of a transmission in reverse, neutral, and drive. The first module generates first signals based on a first position of the first input device. The second input device is different than the first input device and is user actuatable to request operation of the transmission in park. The second module generates second signals based on a second position of the second input device.Type: GrantFiled: March 7, 2013Date of Patent: August 26, 2014Inventor: Orson S. Wang
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Publication number: 20140234395Abstract: Transdermal or topical plasters containing active ingredient are provided that include a non-occlusive back layer, a matrix formed from of one or more polymer layers having at least one pharmaceutical active ingredient in one or more of the layers, in which the structure-forming base polymers of the layer(s) are non-occlusive or only slightly occlusive and a second polymer that has a low water-vapor permeability and that is immiscible or only very slightly miscible with the base polymer is dispersed in at least one of the polymer layers.Type: ApplicationFiled: September 25, 2012Publication date: August 21, 2014Applicant: LTS LOHMANN THERAPIE-SYSTEME AGInventors: Walter Müller, Patrick Mohr
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Patent number: 8802136Abstract: Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.Type: GrantFiled: June 13, 2013Date of Patent: August 12, 2014Assignee: Mylan Technologies, Inc.Inventor: Kenneth J. Miller, II
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Patent number: 8802062Abstract: Disclosed herein is a pair of dry type patches for teeth whitening, having a patch for upper teeth and a patch for lower teeth, in which the patch for upper teeth has a shape different from the patch for lower teeth, and each patch has a controlled width and shape such that the contact area of each patch with gums is minimized. In the patch for upper teeth, a central portion covering right and left upper central incisors is widest. In the patch for lower teeth, either portion covering right and left lower canine teeth is widest. Since the dry type patches covers all the portions of the teeth while minimizing the contact area with gums, no or little irritation is caused and wearability is excellent.Type: GrantFiled: April 28, 2006Date of Patent: August 12, 2014Assignee: LG Household & Healthcare Ltd.Inventors: Ji-Young Kim, Jong-Ho Kim, Sug-Youn Chang, Sei-Young Yun, Hae-Young Yang, Sang-Hoon Kwak
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Patent number: 8802134Abstract: A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.Type: GrantFiled: February 21, 2013Date of Patent: August 12, 2014Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Naruhito Higo, Tetsurou Tateishi, Takaaki Terahara, Kazunosuke Aida, Shigeki Hayashi, Nobuo Tsutsumi