Pressure Sensitive Adhesive Means Patents (Class 424/448)
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Publication number: 20090258060Abstract: Hydrogel compositions are provided (a) that have a continuous hydrophobic phase and a discontinuous hydrophilic phase, (b) that have a discontinuous hydrophilic phase and a continuous hydrophilic phase, or (c) that are entirely composed of a continuous hydrophilic phase. The hydrophobic phase, if present, is composed of a hydrophobic polymer, particularly a hydrophobic pressure-sensitive adhesive (PSA), a plasticizing elastomer, a tackifying resin, and an optional antioxidant. The discontinuous hydrophilic phase, if present, is composed of a crosslinked hydrophilic polymer, particularly a crosslinked cellulosic polymer such as crosslinked sodium carboxymethylcellulose. For those hydrogel compositions containing a continuous hydrophilic phase, the components of the phase include a cellulose ester composition or an acrylate polymer or copolymer, and a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding thereto.Type: ApplicationFiled: June 24, 2009Publication date: October 15, 2009Inventors: Gary W. Cleary, Shoreh Parandoosh, Mikhail M. Feldstein, Anatoly E. Chalykh, Nicolai A. Plate, Valery G. Kulichikhin
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Publication number: 20090252782Abstract: Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.Type: ApplicationFiled: October 23, 2006Publication date: October 8, 2009Applicants: Amorepacific Corporation, Pacific Pharmaceutical Co., LtdInventors: Yang Gyu Choi, Young Chang Ah, Woo Jeong Choi, Jung Ju Kim
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Patent number: 7597900Abstract: Abrasive compositions which include bioactive materials, such as bioactive glass and bioactive ceramics, which provide biological properties such as anti-inflammatory, anti-microbial, anti-oxidant effects, improved wound healing, and/or other beneficial effects are provided. Also provided are abrasive compositions comprising relatively non-toxic, bioinert glasses and ceramics which provide good abrasive effects, reduce or eliminate potentially harmful small particles; reduce or eliminate clogging of dermabrasion equipment; possess a relatively large surface area for applying coatings; and may be inexpensive and simple to make. Methods for abrading human or animal tissue, such as human skin, by contacting such tissue with these abrasive compositions is also provided.Type: GrantFiled: October 30, 2003Date of Patent: October 6, 2009Assignee: Schott AGInventors: Jose Zimmer, Sean Lee, Coni Rosati
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Publication number: 20090246263Abstract: A patch preparation having a backing layer and a drug layer laminated on the backing layer; wherein the drug layer contains an adhesive containing at least one compound selected from the group consisting of fentanyl and pharmaceutically acceptable salts thereof, polyisobutylene, and a silicon-containing polymer; and a mass ratio of the polyisobutylene and the silicon-containing polymer in the adhesive is 20:1 to 7:3.Type: ApplicationFiled: June 27, 2007Publication date: October 1, 2009Inventors: Sachiko Honma, Tetsuro Tateishi
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Publication number: 20090246256Abstract: The present invention provides for compositions and methods for accelerating the rate of delivery of lofexidine to the systemic circulation by transmucosal administration through the nasal, sublingual, or buccal routes to provide rapid response in the treatment of opiate addicts, migraine, neuropathic pain, and other therapeutic indications related to lofexidine, to a patient in need of such treatment. Compositions of lofexidine formulated for transmucosal delivery are provided. Also provided are methods for the treatment of opiate addicts, migraine, neuropathic pain, and other therapeutic indications related to lofexidine. The methods utilize lofexidine compositions formulated for transmucosal delivery through nasal, sublingual, or buccal routes of administration in an amount effective for the treatment of the drug indications.Type: ApplicationFiled: March 24, 2009Publication date: October 1, 2009Inventor: Abeer M. Al-Ghananeem
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Publication number: 20090238860Abstract: Disclosed is an adhesive patch composed of an adhesive base agent and a supporting body wherein the adhesive base agent contains 3-30% by mass of a low-molecular-weight polyisobutylene and aluminum hydroxide and/or titanium oxide but not substantially containing water. Also disclosed is a skin irritation reducing agent used therefore. Further disclosed is an adhesive patch composed of a supporting body and an adhesive base agent which contains a thermoplastic rubber and a low-molecule-weight polyisobutylene but not substantially containing water. This adhesive patch is characterized in that the adhesive base agent further contains aluminum hydroxide and/or titanium oxide. Also disclosed is a skin irritation reducing agent used for such an adhesive patch.Type: ApplicationFiled: August 8, 2006Publication date: September 24, 2009Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Masakazu Saeki, Masato Wakamatsu, Takaaki Yoshinaga
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Publication number: 20090221489Abstract: A film comprising as a film-forming agent an alginate salt of monovalent cation or a mixture of alginate salts containing at least one alginate salt of monovalent cation, the film-forming agent being such that a 10% aqueous solution thereof at a temperature of 20° C. has a viscosity of 100-1000 mPas, as measured at a shear rate of 20 rpm by use of a Brookfield viscometer with a spindle No. 2. A method of preparing the film. The film is useful for delivery of active ingredients to a mammal.Type: ApplicationFiled: December 22, 2006Publication date: September 3, 2009Inventors: Kjell Stenberg, Fredrik Hubinette
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Publication number: 20090208559Abstract: A device for controlled delivery of an active ingredient to a receiving site (1) such as a plant, human or animal. The device comprises a filmic substrate including a water soluble carrier layer (2) disposed between first and second water soluble control layers (3, 4). The second control layer (4) of the filmic substrate is provided with adhesive (5) on the side remote from the carrier layer (2) for attaching the device to the receiving site (1) with the first control layer (3) outermost. The first and second control layers (3, 4) having perforated regions (9, 8) whereby the carrier layer (2) can be dissolved by wetting the first control layer (3) with an aqueous medium that passes through the perforations (9) of the first control layer (3) releasing the active ingredient into solution that passes through the perforations (8) of the second layer (4) to come into contact with the receiving site (1).Type: ApplicationFiled: June 14, 2007Publication date: August 20, 2009Inventors: Bruce Drew, Shilpan Pravinchandra Patel, Nikita Kamlesh Thanawala
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Publication number: 20090208560Abstract: A cover material adapted to cover the entirety of a patch is provided. The cover material has a support layer and, superimposed on a surface thereof, a pressure sensitive adhesive layer. The patch has a support film with a thickness of 12- to 30 ?m and, superimposed thereon, a drug containing layer. The cover material may be attached to the surface of the support film and to the skin around the patch so that the pressure sensitive adhesive layer is brought into contact with edges of the drug containing layer. Additionally, the pressure sensitive adhesive layer contains an adhesive resulting from the polymerization of vinyl acetate or N-vinyl-2-pyrrolidone and a C8 alkyl (meth)acrylate as essential monomers. Thus, there is provided a cover material that, when a patch medicated with, for example, mesylic acid pergolide is fixed on diseased part, such as, a part of the skin, by covering the patch, is capable of reducing irritation, etc. on the diseased part.Type: ApplicationFiled: April 24, 2009Publication date: August 20, 2009Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Kazunosuke AIDA, Arata TOSHIMITSU, Takaaki TERAHARA, Naruhito HIGO
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Publication number: 20090196910Abstract: A preparation of statins for prolonged release. The preparation is a transdermal therapeutic system or hypodermic implantation system. And they overcome the problem of low bioavailability and increase patient compliance. The statins in the invention contain all of statins and responding salts, hydroxyl ester derivatives at 4-position. The invention has many advantages: for example, reduce dosage frequency, remain stable and lasting blood concentration of medicine, further improve the curative effect, provide patients with a convenient and safety means of administration, and obtain an effective period of up to seven days to months by taking medicine once.Type: ApplicationFiled: November 21, 2005Publication date: August 6, 2009Applicant: PFICKER PHARMACEUTICALS LTD.Inventors: Hongping Yie, Zuolin Zhu, Meg M. Sun
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Patent number: 7556823Abstract: Silicone adhesive formulations are provided, in which fentanyl particles are suspended in one or more solvated silicone adhesives. The formulations can be used for manufacturing improved, matrix-type transdermal devices for administering fentanyl.Type: GrantFiled: October 28, 2008Date of Patent: July 7, 2009Assignee: Mylan Pharmaceuticals, Inc.Inventors: Kenneth J. Miller, II, Sharad K. Govil, Kuljit Singh Bhatia
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Publication number: 20090169605Abstract: It is intended to provide a preparation for percutaneous administration of 2-(4-ethyl-1-piperazinyl)-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine (Compound A), which inhibits the generation of a metabolite and is capable of continuously maintaining a blood drug level. Specifically, a tape preparation comprising an adhesive layer formed on one surface of a support, characterized in that the adhesive layer contains (1) Compound A or a physiologically acceptable acid addition salt thereof, and (2) an acrylic adhesive, or (1) Compound A or a physiologically acceptable acid addition salt thereof, (2) an acrylic adhesive, and (3) a permeation enhancer is provided.Type: ApplicationFiled: June 7, 2007Publication date: July 2, 2009Inventors: Hiroo Maeda, Naoki Ohara
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Publication number: 20090169603Abstract: In the adhesive pharmaceutical preparation of the invention, a pressure-sensitive adhesive layer is laminated on one side of the backing. The pressure-sensitive adhesive layer contains a branched monoalcohol having from 12 to 28 carbon atoms, a drug which is liquid at room temperature or around room temperature (in which, free base of bisoprolol is excluded) and a polyisobutylene pressure-sensitive adhesive. Accordingly, compatibility of the polyisobutylene pressure-sensitive adhesive with the drug can be specifically increased. As a result, not only it becomes possible to increase blending amount of the drug but also bleed of the drug from the pressure-sensitive adhesive layer can be suppressed and, what is more, the pressure-sensitive adhesion characteristics sufficient from the practical point of view can be obtained.Type: ApplicationFiled: December 13, 2006Publication date: July 2, 2009Applicant: NITTO DENKO CORPORATIONInventors: Yoshihiro Iwao, Katsuyuki Ookubo, Katsuhiro Okada
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Publication number: 20090169602Abstract: The invention provides pharmaceutical compositions, kits, and methods for the treatment of allergy. The compositions are adapted for epicutaneous administration and comprise an allergen and at least one pharmaceutically acceptable excipient. They may be designed as adhesive patches, intradermal delivery devices, ointments, gels, sprays, or similar types of formulation suitable for administration to the skin. Furthermore, the invention provides the use of such compositions in the treatment of allergy. In particular, the compositions are administered to pre-treated skin, wherein the pre-treatment comprises partial or complete dekeratinisation of the epidermis at the selected site of administration.Type: ApplicationFiled: November 23, 2006Publication date: July 2, 2009Applicant: UNIVERSITÄT ZÜRICHInventors: Gabriela Senti, Thomas Kuendig
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Publication number: 20090169601Abstract: A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups: a) terpenes, b) cyclic glucitol ethers, c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms.Type: ApplicationFiled: October 4, 2006Publication date: July 2, 2009Applicant: LTS Lohmann Therapie-Systeme AGInventors: Andreas Koch, Christoph Schmitz, Rolf Pracht, Mohammad Sameti
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Publication number: 20090169604Abstract: In the adhesive pharmaceutical preparation of the invention containing bisoprolol, a pressure-sensitive adhesive layer is laminated on one side of the backing. The pressure-sensitive adhesive layer contains a branched monoalcohol having from 12 to 28 carbon atoms, a free base of bisoprolol and a polyisobutylene pressure-sensitive adhesive. Accordingly, compatibility of the polyisobutylene pressure-sensitive adhesive with the free base of bisoprolol can be specifically increased. As a result, not only it becomes possible to increase blending amount of the free base of bisoprolol but also bleed of the free base of bisoprolol from the pressure-sensitive adhesive layer can be suppressed and, what is more, the pressure-sensitive adhesion characteristics sufficient from the practical point of view can be obtained.Type: ApplicationFiled: December 13, 2006Publication date: July 2, 2009Applicants: NITTO DENKO CORPORATION, TOA EIYO LTD.Inventors: Yoshihiro Iwao, Katsuyuki Ookubo, Katsuhiro Okada, Kunihiro Minami, Shuichiro Yuasa
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Publication number: 20090148504Abstract: A percutaneous administration type pharmaceutical preparation in tape form comprising a flexible backing, which is not permeable by the active ingredient, and an adhesive base layer formed on said flexible backing; said adhesive base layer consisting essentially of an adhesive base material, ingredients, and an active ingredient, wherein said adhesive base is a copolymer containing one or more (meth) alkyl acrylate monomers and one or more monomers copolymerizable with the (a) monomer selected from the group of unsaturated ethylenically unsaturated monomers, and said ingredients are diethylene glycol monocetyl ether, octanoic acid and/or oleic acid, lauric acid diethanolamide, polyvinylpyrollidone; and said active ingredient is fentanyl.Type: ApplicationFiled: January 23, 2009Publication date: June 11, 2009Inventors: Fumio Kamiyama, Ying-shu Quan
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Publication number: 20090123526Abstract: A transdermally absorbable preparation that even when a drug with poor solubility in a base is added in high concentration, is stable over time and can suppress crystallization of the drug, excelling in transdermal absorbability. There is provided a transdermally absorbable preparation, comprising a base and, added thereto, at least composite particles which are composed of a silicate compound and an organic acid and a drug.Type: ApplicationFiled: February 28, 2006Publication date: May 14, 2009Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventor: Mitsuru Kuribayashi
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Publication number: 20090110717Abstract: The invention provides a composition for delivering active agents through transmucosal administration, more particularly through the buccal mucosa. The composition is a unique transmucosal disk (10) which has two compartments (14) and (18); the compartments consist of at least one active agent and at least one mucoadhesive agent and both the compartments are adapted to be in contact with the mucosal membrane. The invention also provides for transmucosal administration of an active agent and method of treatment of diseases in a subject in need of such treatment.Type: ApplicationFiled: April 25, 2007Publication date: April 30, 2009Inventors: Amarjit Singh, Sarabjit Singh, Shivanand Puthli
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Patent number: 7517536Abstract: The present invention relates to a wound dressing comprising a flexible base layer and an antimicrobial material, wherein the antimicrobial material comprises an activated carbon-carried noble metal, the activated carbon is selected from the group consisting of an activated carbon powder, an activated carbon particle, an activated carbon fiber, and a combination thereof, and the noble metal is selected from the group consisting of silver, gold, palladium, platinum, copper, zinc, and a combination thereof. The invention also relates to an antimicrobial composition for topical use on skin, in which the composition comprises the aforementioned activated carbon-carried noble metal.Type: GrantFiled: February 3, 2006Date of Patent: April 14, 2009Assignee: Feng Chia UniversityInventor: Tse-Hao Ko
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Publication number: 20090068252Abstract: A transdermal absorption preparation having a support and a pressure-sensitive adhesive layer consisting of multiple layers, wherein the pressure-sensitive adhesive layer comprises a drug-retaining layer containing a drug and an acrylic pressure-sensitive adhesive and a skin adhesion layer containing a styrene-isoprene-styrene block copolymer. This preparation can continuously release bisoprolol at a constant concentration. Moreover, it can be easily produced.Type: ApplicationFiled: February 27, 2007Publication date: March 12, 2009Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Satoshi Amano, Sachiko Honma, Tetsuro Tateishi, Natsumi Kase
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Publication number: 20090060986Abstract: Disclosed are bupivacaine transdermal delivery systems, and related methods.Type: ApplicationFiled: October 29, 2007Publication date: March 5, 2009Inventors: Su II Yum, Sung Yun Kwon, Xiaoping Song, James E. Brown
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Publication number: 20090047333Abstract: The present invention aims at providing a pressure-sensitive adhesive composition applicable to nail, which shows superior adhesive performance (adhesive force, cohesion etc.), and superior drug releasability and drug stability, and an adhesive agent for nail, which uses this composition. The composition of the present invention contains a condensation polymer of a silicone resin and a silicone rubber. The composition of the present invention preferably contains not less than two kinds of condensation polymers having different resin/rubber ratios. The adhesive agent of the present invention has a support and an adhesive layer formed on one surface of the support, which contains the above-mentioned composition.Type: ApplicationFiled: October 9, 2008Publication date: February 19, 2009Inventors: Akinori Hanatani, Hitoshi Akemi
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Publication number: 20090041831Abstract: Silicone adhesive formulations are provided, in which fentanyl particles are suspended one or more a solvated silicone adhesives. The formulations can be used for manufacturing improved, matrix-type transdermal devices for administering fentanyl.Type: ApplicationFiled: October 28, 2008Publication date: February 12, 2009Applicant: Mylan LaboratoriesInventors: Kenneth J. Miller, II, Sharad K. Govil, Kuljit Singh Bhatia
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Publication number: 20090028929Abstract: A transdermal patch suitable for the administration of nitroglycerin.Type: ApplicationFiled: September 22, 2006Publication date: January 29, 2009Inventors: Paola Stefanelli, Sergio Comuzio
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Publication number: 20090028930Abstract: A bruise amelioration composition that can be applied for one hour to an affected site, such as a bruise, contusion or blister, in the form of a gel, liquid or adhesive bandage. The composition includes at least 40% by weight of glycerin and at least 2% by weight of primrose oil. Preferably, the composition includes a fragrance, such as peach oil and marjoram and 1% to 10% by weight of vitamins A, C, D, E and K.Type: ApplicationFiled: October 9, 2008Publication date: January 29, 2009Inventors: Bruce A. CRANNER, Anne-Marie T. KARP
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Publication number: 20090004256Abstract: An adhesive patch for external use which is significantly inhibited from causing a rash, is less irritative to the skin, and sufficiently retains adhesion to the skin. The adhesive patch is characterized by employing a pressure-sensitive adhesive base into which a sucrose fatty acid ester has been incorporated. It does not exert physical influences on the skin, such as stresses imposed on the skin during wear and upon peeling, while sufficiently retaining adhesion to the skin. It is significantly inhibited from causing a rash, and the skin irritation thereof has been minimized. This adhesive patch for external use has ideal, lowly irritative properties which have been impossible to any conventional adhesive patch for external use.Type: ApplicationFiled: August 26, 2008Publication date: January 1, 2009Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Takaaki Yoshinaga, Masato Wakamatsu, Masato Shirai, Masakazu Saeki
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Patent number: 7470433Abstract: The present invention relates generally to formulations for transdermal or transmucosal administration of an active agent such as estradiol. The invention is a substantially malodorous-free and irritation free transdermal formulation which is substantially free of long chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters.Type: GrantFiled: March 30, 2007Date of Patent: December 30, 2008Assignee: Antares Pharma IPL AGInventors: Dario Norberto R. Carrara, Arnaud Grenier, Celine Besse, Stephen M. Simes, Leah M. Lehman
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Publication number: 20080305154Abstract: A transdermal medicament patch includes a biocompatible substrate having a therapeutic face on one side configured for disposition against the skin of a patient, a biocompatible adhesive on the therapeutic face, a planar medicament matrix covering a portion of the therapeutic face, and a release liner covering the portion of therapeutic that is not obscured by the medicament matrix. An aperture formed through the release sheet affords direct access by medicament to the entire surface of the medicament matrix opposite from the therapeutic face of the substrate. An active electrode positioned between the medicament matrix and the therapeutic face of the substrate includes an electrically conductive backing layer positioned against the therapeutic face of the substrate and a pH-control layer covering less than all of the side of the backing layer opposite from the therapeutic face of the substrate.Type: ApplicationFiled: June 8, 2007Publication date: December 11, 2008Inventor: Jamal S. Yanaki
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Publication number: 20080295960Abstract: A silicone adhesive composition used for adhering a device or a substance to a wet surface contains (i) a silicone resin that is cohydrolysis product of a trialkyl hydrolyzable silane and an alkyl silicate in which the cohydrolysis product contains a plurality of silicon-bonded hydroxy groups; (ii) a linear organopolysiloxane fluid containing terminal silicon-bonded hydroxy groups having a viscosity above 200,000 mm2/s at 25° C.; (iii) a trialkylsiloxy terminated polyorganosiloxane fluid having a viscosity of 100,000-600,000 mm2/s at 25° C.Type: ApplicationFiled: January 3, 2007Publication date: December 4, 2008Inventors: Gerald Kenneth Schalau II, Xavier Jean-Paul Thomas, Victor Albert Raul, David Clayton Gantner
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Patent number: 7459171Abstract: The invention relates to a method, a kit and a device for controlling the flux of penetrants across an adaptable semi-permeable porous barrier, the method comprising the steps of: preparing a formulation by suspending or dispersing said penetrants in a polar liquid in the form of fluid droplets surrounded by a membrane-like coating of one or several layers, said coating comprising at least two kinds of forms of amphiphilic substances with a tendency to aggregate, said penerants being able to transport agents through the pores of said barrier or to enable agent permeation through the pores of said barrier after penetrants have entered the pores, selecting a dose amount of said penetrants to be applied on a predetermined area of said barrier to control the flux of said penetrants across said barrier, and applying the selected dose amount of said formulation containing said penetrants onto said area of said porous barrier.Type: GrantFiled: January 4, 2002Date of Patent: December 2, 2008Assignee: Idea AGInventors: Gregor Cevc, Holger Richardsen, Andrea Weiland-Waibel
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Patent number: 7456236Abstract: To offer adhesives for percutaneous absorption, adhesive compositions for percutaneous absorption and preparations for percutaneous absorption which show high ability to dissolve drugs and to dissolve absorption promoting agents and enable high percutaneous absorption and have suitable cohesion and adhesion and do not damage the skin when detached. Adhesives for percutaneous absorption which comprise a copolymer in which the constituents are methoxyethyl acrylate 40-60 wt %, lauryl(meth)acrylate 30-40 wt % and a polar monomer 10-25 wt % only.Type: GrantFiled: March 26, 2004Date of Patent: November 25, 2008Assignee: Cosmed Pharmaceutical Co., Ltd.Inventor: Minoru Kohara
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Patent number: 7456331Abstract: A skin-contacting adhesive composition is described which has improved initial tack, long-term adhesion, water uptake and translucency characteristics and may be prepared by melt extrusion. Uses of these compositions are also described, for example, their use in wound dressings, adhesive cushions, and transdermal drug delivery devices.Type: GrantFiled: November 7, 2006Date of Patent: November 25, 2008Assignees: Corium International, Inc., A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of SciencesInventors: Valery G. Kulichikhin, Shoreh Parandoosh, Mikhail M. Feldstein, Sergey Antonov, Gary W. Cleary
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Patent number: 7455654Abstract: An apparatus for transdermally delivering a nicotine-based agent to a tobacco or nicotine user comprising a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the tobacco user, the microprojection member having a biocompatible coating disposed thereon that includes a nicotine-based agent.Type: GrantFiled: October 21, 2004Date of Patent: November 25, 2008Assignee: Alza CorporationInventors: Michel J. N. Cormier, Robert M. Gale, Andrew G. Scott
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Publication number: 20080279914Abstract: There is disclosed a transdermal composition comprising from about 0.1 to 25% by weight of a piroxicam-inorganic material complex composed of a swellable clay and piroxicam intercalated between layers thereof, from about 50 to 80% by weight of an adhesive polymeric material, and from about 0.1 to 25% by weight of an absorption enhancer. There is further disclosed a transdermal patch system comprising the subject transdermal composition. In the transdermal composition, piroxicam is dispersed on a molecular level between layers of a clay material. As a result, the dispersability, stability and solubility of the piroxicam are improved, the recrystallization of the piroxicam is prevented, and excellent absorption properties and skin permeability of the piroxicam are achieved. Therefore, excellent anti-inflammatory and analgesic effects are exhibited, little or no skin irritation is caused, thereby preventing occurrence of side effects, and the active ingredient is continuously administered by a transdermal route.Type: ApplicationFiled: November 9, 2006Publication date: November 13, 2008Inventors: Jae Hoon Jo, Eun Mi Lee, Yang Su Han, Gee Young Jung
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Patent number: 7438203Abstract: The invention relates to a method for treatment or prophylaxis of a disease or condition in an animal comprising administering to a mucosal membrane of said animal in need of such treatment a therapeutically effective amount of a drug delivery system comprising at least one physiologically active agent or prodrug thereof and at least one penetration enhancer selected from safe ester sunscreens.Type: GrantFiled: January 20, 2004Date of Patent: October 21, 2008Assignee: Acrux DDS Pty LtdInventors: Barry Lenard Reed, Timothy Matthias Morgan, Barrie Charles Finnin
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Publication number: 20080254106Abstract: The present invention relates to the use of Pirlindole, if needed with suitable adjuvants and additives for the production of a medicament for the treatment of diseases characterized by hyperproliferation of keratinocytes and/or T cells, in particular psoriasis and neurodermatitis as well as compositions comprising Pirlindole and use thereof.Type: ApplicationFiled: November 2, 2005Publication date: October 16, 2008Applicant: SWITCH BIOTECH AGInventor: Stefan Bell
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Publication number: 20080241216Abstract: A preparation containing active and/or auxiliary substance(s) for the time- and/or dose-controllable release of said substances, comprising at least two layers (1, 2) in rolled or folded shape, is characterized in that a) the first layer contains at least one active or auxiliary substance, is continuous at least in sections thereof, that at least one of the parameters thickness, width and concentration of the active and/or auxiliary substance of this layer is not constant, and b) in that the second layer is continuous and possesses a lower moisture permeability than the first layer.Type: ApplicationFiled: February 14, 2008Publication date: October 2, 2008Applicant: LTS Lohmann Therapie-Systeme AGInventors: Christian VON FALKENHAUSEN, Markus KRUMME
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Publication number: 20080233177Abstract: A transdermal therapeutic system which is free of fibrous constituents, and a method for the production of such a transdermal therapeutic system A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system.Type: ApplicationFiled: February 28, 2006Publication date: September 25, 2008Applicant: LTS Lohmann Therapie-Systeme AGInventor: Reinhold Meconi
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Publication number: 20080226697Abstract: A pressure-sensitive adhesive composition for transdermal absorption which contains a drug and a transdermal absorption promoter for the drug, characterized by further containing polyvinylpyrrolidone so as to stabilize the transdermal absorption promoter contained in the adhesive composition. Thus, the transdermal absorption promoter can be prevented from vaporization or degradation and a patch for external use containing the transdermal absorption promoter at a high concentration in using can be provided.Type: ApplicationFiled: April 21, 2005Publication date: September 18, 2008Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Toshiro Yamaguchi, Tsuyoshi Endo, Tetsuro Tateishi, Naruhito Higo
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Publication number: 20080226698Abstract: The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of an active agent substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing at least one supersaturated active agent substantially in amorphous form. Further, the present invention refers to a method to stabilize and a method to reestablish the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.Type: ApplicationFiled: March 16, 2007Publication date: September 18, 2008Applicant: Mylan Technologies, Inc.Inventors: Jiansheng Tang, Joseph M. Deverich, Kenneth J. Miller, Russell D. Beste
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Publication number: 20080206315Abstract: The present invention aims at providing an adhesive preparation wherein a drug is sufficiently dissolved in an adhesive layer and is not easily separated from the adhesive layer even during preservation of the adhesive preparation. The present invention provides an adhesive preparation having an adhesive layer on at least one surface of a support, wherein the adhesive layer comprises a first synthetic rubber having a viscosity average molecular weight of 1,600,000-6,500,000, a drug, an organic liquid component and a tackifier. The present invention further provides the aforementioned adhesive preparation, wherein the organic liquid component is contained in the adhesive layer in a proportion of 20 wt % or above relative to the total weight of the adhesive layer.Type: ApplicationFiled: February 27, 2008Publication date: August 28, 2008Inventors: Masato Nishimura, Sachiko Terashi, Shiro Satoda, Keigo Inosaka, Kensuke Matsuoka
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Publication number: 20080206314Abstract: Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.Type: ApplicationFiled: October 21, 2005Publication date: August 28, 2008Inventors: Su II Yum, Felix Theeuwes
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Patent number: 7413747Abstract: A transdermal therapeutic system (TTS) comprises a silicone-based polymer adhesive system having distributed therein (?)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol free base in an amount of about 5% to 40% by weight. The adhesive system comprises a silicone adhesive and an additive having increased solubility for the active substance, in an amount effective to increase dissolving capacity of the matrix for the active substance.Type: GrantFiled: October 31, 2007Date of Patent: August 19, 2008Assignees: LTS Lohmann Therapie-Systeme AG, Schwarz Pharma LimitedInventors: Walter Mueller, James V. Peck
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Publication number: 20080175889Abstract: A solution of polyether polyurethane resin dissolved in a solvent system containing 2-methyloxolane (2-MeOX) solvent and at least one volatile co-solvent. The solution may also contain a functional amount of solubilized adhesive agent. Upon drying, the resulting protective elastic film has good adhesion to human and other animal skin. The solution penetrates vital tissue to a lesser extent than a comparable solution prepared using tetrahydrofuran solvent.Type: ApplicationFiled: January 23, 2007Publication date: July 24, 2008Inventor: Daniel Perlman
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Publication number: 20080175890Abstract: Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.Type: ApplicationFiled: July 31, 2007Publication date: July 24, 2008Inventors: Su Il Yum, Felix Theeuwes
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Patent number: 7399484Abstract: The present invention relates to a patch and method for providing therapy to an individual. The patch and method provide a user or therapist with the flexibility to apply a patch to highly contoured areas on the individual's body. In some embodiments, the patch includes a body that applies therapy to the individual when the patch is placed on the individual. The patch further includes at least one cut in the body of the patch. In other example embodiments, the present invention relates to a method of providing therapy to an individual. The method includes selecting a patch that provides therapy to an individual. The patch includes a body and at least one cut in the body. The method further includes applying the patch to the individual where the cut in the body allows the patch to conform to the individual as the patch is applied to the individual.Type: GrantFiled: June 30, 2004Date of Patent: July 15, 2008Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Kimberly L. Ellefson, James D. Milner, MeeWha Lee
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Publication number: 20080156821Abstract: Topical preparation dispensers and methods of using the same are provided. Aspects of the invention include a topical preparation dispenser having a holder, one or more vertically stacked topical preparations in the holder, and a cap at one end of the holder configured such that upon movement of the cap, a topical preparation is exposed and moved relative to the holder. Also provided are kits that include the subject dispensers.Type: ApplicationFiled: October 9, 2007Publication date: July 3, 2008Inventors: BRADLEY STUART GALER, GREGORY JAY GALER
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Patent number: 7390935Abstract: The present invention includes a patch. The patch includes a main body with a base portion and a vapor emitting portion. The base portion includes a hydrogel comprising a first surface and an opposing surface. The vapor emitting portion is attached to the first surface of the hydrogel. A vapor emitting material is incorporated in the vapor emitting portion.Type: GrantFiled: October 19, 2000Date of Patent: June 24, 2008Assignee: Ideagen IncorporatedInventor: Mark H. Theno
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Publication number: 20080138389Abstract: A substantially solvent-free matrix layer containing (?)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol is produced by adding an active substance to an adhesive solution, coating the resultant active substance-containing adhesive solution onto a suitable sheet, and removing the solvents in a drying process to give said substantially solvent-free matrix layer.Type: ApplicationFiled: October 31, 2007Publication date: June 12, 2008Inventors: Walter Muller, James V. Peck