Pressure Sensitive Adhesive Means Patents (Class 424/448)
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Patent number: 8287899Abstract: The invention relates to a patch for cutaneous application of a substance, the patch comprising a substance designed to penetrate the epidermis, means for placing the substance in contact with the skin and a peelable cutaneous exfoliation film enabling exfoliation of the skin, after placing the patch, at the level of the contact zone between said substance and the skin.Type: GrantFiled: February 15, 2008Date of Patent: October 16, 2012Assignee: DBV TechnologiesInventor: Bertrand Dupont
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Patent number: 8287901Abstract: A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenyloin; and a method for making said composition.Type: GrantFiled: August 11, 2010Date of Patent: October 16, 2012Assignee: Adhezion Biomedical, LLCInventors: Sheng Zhang, Rafael Ruiz, Sr.
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Patent number: 8277838Abstract: A blend of at least two polymers in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. According to the invention, providing drug having differing crystal sizes as well as drug which is solublized in the pressure-sensitive adhesive composition controls the rate of drug delivery from the pressure-sensitive adhesive composition.Type: GrantFiled: December 28, 2010Date of Patent: October 2, 2012Assignee: Noven Pharmaceuticals, Inc.Inventor: Viet Nguyen
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Publication number: 20120231064Abstract: The present invention relates to a pharmaceutical delivery device for application of a pharmaceutical to mucosal surfaces. The device comprises an adhesive layer and a non-adhesive backing layer, and the pharmaceutical may be provided in either or both layers. Upon application, the device adheres to the mucosal surface, providing localized drug delivery and protection to the treatment site. The kinetics of erodability are easily adjusted by varying the number of layers and/or the components.Type: ApplicationFiled: October 10, 2011Publication date: September 13, 2012Applicant: BIODELIVERY SCIENCES INTERNATIONAL, INC.Inventors: Gilles H. Tapolsky, David W. Osborne
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Patent number: 8263680Abstract: Acrylic polymers comprising vinyl acetate monomers, hydroxyl functional monomers and low Tg alkyl acrylate monomers are useful in adhesive compositions that find use in skin contact applications.Type: GrantFiled: September 22, 2006Date of Patent: September 11, 2012Assignee: Henkel AG & Co. KGaAInventors: Allison Luciano, Eric N. Silverberg, Paul B. Foreman, Jianye Wen, Eli J. Goldman, Jay Audette
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Patent number: 8252320Abstract: Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.Type: GrantFiled: July 31, 2007Date of Patent: August 28, 2012Assignee: Durect CorporationInventors: Su Il Yum, Felix Theeuwes
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Patent number: 8252319Abstract: Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.Type: GrantFiled: July 31, 2007Date of Patent: August 28, 2012Assignee: Durect CorporationInventors: Su Il Yum, Felix Theeuwes
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Patent number: 8252317Abstract: The present invention provides novel metal alginates prepared from non-cross-linked alginate monomers such as sodium alginate and an aqueous solution of a group 4, 5, or 6 metal oxyhalide. The novel group 4, 5, and 6 metal alginates are useful in the preparation of cell culture supports, exhibit useful X-ray contrast properties, and exhibit unanticipated stability to standard autoclave conditions relative to known metal alginates such as calcium alginate. In general, the novel metal alginates provided by the present invention offer features and properties not observed in known metal alginates such as calcium or barium alginates.Type: GrantFiled: February 26, 2009Date of Patent: August 28, 2012Assignee: General Electric CompanyInventors: Andrew Soliz Torres, Peter John Bonitatibus, Jr.
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Patent number: 8246976Abstract: A blend of at least two polymers in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. According to the invention, providing drug having differing crystal sizes as well as drug which is solublized in the pressure-sensitive adhesive composition controls the rate of drug delivery from the pressure-sensitive adhesive composition.Type: GrantFiled: October 7, 2005Date of Patent: August 21, 2012Assignee: Noven Pharmaceuticals, Inc.Inventor: Viet Nguyen
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Patent number: 8246978Abstract: This invention relates to a transdermal drug delivery device that comprises an active ingredient (AI) layer, having a skin contacting surface and a non-skin contacting surface and comprising a volatile component, a release liner impermeable to the volatile component adjacent the skin contacting surface of the AI layer having a perimeter that extends beyond the perimeter of the AI layer in all directions, and an overlay comprising a pressure sensitive adhesive (PSA) that does not absorb the volatile component adjacent the non-skin contacting surface of the AI layer having a perimeter of which extends beyond the perimeter of the AI layer in all directions, wherein the release liner and the PSA of the overlay are in contact with and adhered to each other around the perimeter of the AI layer to form a seal that reduces or prevents volatile component loss.Type: GrantFiled: July 10, 2008Date of Patent: August 21, 2012Assignee: Agile Therapeutics, Inc.Inventors: Agis Kydonieus, Robert G. Conway, Thomas M. Rossi
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Patent number: 8246977Abstract: Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.Type: GrantFiled: October 21, 2005Date of Patent: August 21, 2012Assignee: Durect CorporationInventors: Su Il Yum, Felix Theeuwes
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Patent number: 8246982Abstract: A pressure sensitive adhesive for medicinal application purposes, based on ethylene-vinyl acetate copolymers is characterized in that it contains as polymer component (A) an ethylene-vinyl acetate copolymer or a combination of at least two ethylene-vinyl acetate copolymers, and as component (B) an adhesive resin or a combination of adhesive resins at a portion of up to 55%-wt, relative to the sum of components (A) and (B) without active substances or other auxiliary substances.Type: GrantFiled: November 1, 2010Date of Patent: August 21, 2012Assignee: LTS Lohmann Therapie-Systeme AGInventors: Andreas Koch, Christoph Schmitz
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Patent number: 8246979Abstract: An improved transdermal delivery system (TDS) comprises a self-adhesive matrix comprising a solid or semi-solid semi-permeable polymer which contains rotigotine in its free base form as a multitude of microreservoirs within the matrix. The self-adhesive matrix is highly permeable to the free base of rotigotine and is impermeable to the protonated form of rotigotine.Type: GrantFiled: July 22, 2003Date of Patent: August 21, 2012Assignee: UCB Pharma GmbHInventors: Dietrich Wilhelm Schacht, Mike Hannay, Hans-Michael Wolff
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Patent number: 8241660Abstract: This invention relates to a patch for the expulsion of insect poison from the skin after stings from membranous insects (Hymenoptera). The patch is characterized in comprising a poison-aspirating matrix comprising an expulsion agent as well as a swell layer, which swells after the addition of a liquid through a hole on the top of the patch and thus adds a light pressure to the poison-aspirating matrix towards the skin, whereby a local and relieving effect is achieved. In one embodiment, the matrix further comprises a local anesthetic. The expulsion agent is e.g. a carbohydrate. The swell layer consists e.g. of a silica gel.Type: GrantFiled: August 20, 2007Date of Patent: August 14, 2012Inventor: Martin Wenckens
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Patent number: 8241662Abstract: The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder. In some aspects, the composition may be presented in the form of an unoccluded or free form topically administered gel.Type: GrantFiled: December 21, 2006Date of Patent: August 14, 2012Assignee: Watson Laboratories, Inc.Inventors: Charles D. Ebert, Steven W. Sanders
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Patent number: 8237010Abstract: A therapeutic device for promoting the healing of a wound in a mammal is disclosed. An exemplary device comprises a permeable structure having a plurality of depressions formed in a surface thereof. In use, the surface having the depressions is disposed adjacent a surface of the wound. A method of manufacturing a therapeutic device for promoting the healing of a wound in a mammal comprising the steps of providing a permeable substrate, and forming a plurality of depressions into a surface of the permeable substrate to provide the therapeutic device. A method of treating a wound comprises: providing a permeable structure comprising a plurality of randomly disposed fibers and having i) a plurality of wound surface contact elements disposed between end portions of the structure, and ii) a plurality of voids defined by the contact elements; and applying the permeable structure to at least one surface of the wound.Type: GrantFiled: August 30, 2011Date of Patent: August 7, 2012Assignee: Boehringer Technologies, L.P.Inventors: John R. Boehringer, John Karpowicz, Christopher L. Radl
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Publication number: 20120195956Abstract: The present invention provides an adhesive skin patch that permits excellent and prolonged percutaneous absorption of tulobuterol and that can be stably applied to the skin for a long period of time with less skin irritation. The adhesive skin patch comprises a base material and a medicated layer provided on one surface of the base material. The medicated layer contains 1 to 30% by weight of a resolvent, 40 to 98% by weight of a pressure-sensitive adhesive, and tulobuterol. The resolvent contains an aliphatic alcohol having a branched-chain structure or a double bond in its C8 to C30 carbon chain. The pressure-sensitive adhesive is a copolymer obtained by copolymerizing monomers containing 70% by weight or more of an alkyl(meth)acrylate whose alkyl group has 6 to 20 carbon atoms.Type: ApplicationFiled: April 12, 2012Publication date: August 2, 2012Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Hiroko Udagawa, Toshikazu Komoda, Masaru Hamabe
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Publication number: 20120189686Abstract: Described are transdermal drug delivery systems for the transdermal administration of levonorgestrel, comprising a polymer matrix and levonorgestrel acetate. Methods of making and using such systems also are described.Type: ApplicationFiled: December 27, 2011Publication date: July 26, 2012Inventors: David W. Houze, Vincent Lau Chan
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Patent number: 8226974Abstract: The invention relates to transdermal therapeutic systems which have the active ingredient nicotine and have particularly high flexibility. This flexibility decisively improves wearer comfort on the skin, since the system is readily capable of adapting to the surface of the skin and its constant movement. Surprisingly, the nicotine TTS of the invention is markedly more flexible than the conventional nicotine TTS products which are leaders in the market, although at least some of those systems are comparably thin.Type: GrantFiled: February 19, 2002Date of Patent: July 24, 2012Assignee: LTS Lohmann Therapie-Systeme AGInventors: Stefan Bracht, Sabine Warnus
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Patent number: 8221785Abstract: A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.Type: GrantFiled: September 10, 2009Date of Patent: July 17, 2012Assignee: Agile Therapeutics, Inc.Inventor: Te-Yen Chien
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Patent number: 8221784Abstract: A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.Type: GrantFiled: August 19, 2009Date of Patent: July 17, 2012Assignee: Agile Therapeutics, Inc.Inventor: Te-Yen Chien
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Patent number: 8216606Abstract: A dermal composition for administration of a drug comprising a blend of two or more acrylic-based polymers having differing functionalities so as to modulate the drug solubility in the polymer matrix and the delivery rate of the drug, and methods therefor.Type: GrantFiled: October 24, 2005Date of Patent: July 10, 2012Assignee: Noven Pharmaceuticals, Inc.Inventors: David Houze, Juan Mantelle, David Kanios
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Patent number: 8206738Abstract: A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening. The composition can be designed to be removed when the degree of whitening has been achieved or left in place and allowed to erode entirely. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.Type: GrantFiled: September 12, 2003Date of Patent: June 26, 2012Assignees: Corium International, Inc., A.V. Topchiev Institute of Petrochemical SynthesisInventors: Parminder Singh, Adrian Faasse, Gary W. Cleary, Sri Mudumba, Mikhail M. Feldstein, Danir R. Bairamov
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Patent number: 8197843Abstract: An article having an adhesive surface for adhering to human skin that includes a first component constituting a continuous layer and at least a second component which is located in indentations in the adhesive surface of the first component without being in direct contact with the first component. The second component is separated from the first component by a cup shaped barrier layer having a rim which extends into a flange.Type: GrantFiled: September 20, 2002Date of Patent: June 12, 2012Assignee: Coloplast A/SInventors: Michael Pilgaard, Jan Marcussen
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Patent number: 8197844Abstract: A transdermal medicament patch includes a biocompatible substrate having a therapeutic face on one side configured for disposition against the skin of a patient, a biocompatible adhesive on the therapeutic face, a planar medicament matrix covering a portion of the therapeutic face, and a release liner covering the portion of therapeutic that is not obscured by the medicament matrix. An aperture formed through the release sheet affords direct access by medicament to the entire surface of the medicament matrix opposite from the therapeutic face of the substrate. An active electrode positioned between the medicament matrix and the therapeutic face of the substrate includes an electrically conductive backing layer positioned against the therapeutic face of the substrate and a pH-control layer covering less than all of the side of the backing layer opposite from the therapeutic face of the substrate.Type: GrantFiled: June 8, 2007Date of Patent: June 12, 2012Assignee: Activatek, Inc.Inventor: Jamal S. Yanaki
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Patent number: 8187628Abstract: A dermal composition for administration of an amphetamine drug comprising a blend of two or more acrylic-based polymers having differing functionalities so as to modulate the drug solubility in the polymer matrix and the delivery rate of the drug, and methods therefor.Type: GrantFiled: October 24, 2005Date of Patent: May 29, 2012Assignee: Noven Pharmaceuticals, Inc.Inventors: David Houze, Juan Mantelle, David Kanios
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Patent number: 8182647Abstract: A moisture-curable and biodegradable adhesive that includes the reaction product of: (a) an isocyanate component having an average functionality of at least 2; (b) an active hydrogen component having an average functionality greater than 2.1; and (c) an ionic salt component having an average hydroxyl or amino functionality, or combination thereof, of at least 1.Type: GrantFiled: May 20, 2008Date of Patent: May 22, 2012Assignee: Cohera Medical, Inc.Inventors: Jason Smith, Eric Beckman
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Patent number: 8183427Abstract: A biodegradable microfiber absorbent comprises a substantially homogeneous mixture of at least one hydrophilic polymer and at least one biodegradable polymer. The absorbent can be prepared by an electro hydrodynamic spinning of a substantially homogeneous polymer mixture. Medical dressings for burns and wounds, cavity dressings, drug delivery patches, face masks, implants, drug carriers that comprises at least one microfiber electrospun from a polymer mixture are provided. The dressings can have variable water vapor penetration characteristics and variable biodegradation times.Type: GrantFiled: December 7, 2010Date of Patent: May 22, 2012Inventors: Bronislava G. Belenkaya, Valentina I. Sakharova, Vyacheslav N. Polevov, Claudia Polevov, legal representative
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Publication number: 20120114738Abstract: The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAE or its pharmacologically acceptable salt. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: 2-amino-1-(2?,5?-dimethoxyphenyl)ethanol or its pharmacologically acceptable salt; 40 to 98% by weight of acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and 1 to 30% by weight of saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 10 to 30.Type: ApplicationFiled: January 17, 2012Publication date: May 10, 2012Inventors: Toshikazu KOMODA, Hiroko Udagawa, Masaru Hamabe, Yukihiko Noda, Sakiko Shibata, Masashi Yamada, Akihiro Kawashima, Hiroto Suzuki
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Publication number: 20120114737Abstract: A silicone acrylate hybrid composition includes the reaction product of a silicon-containing pressure sensitive adhesive composition, an ethylenically unsaturated monomer, and an initiator. The silicon-containing pressure sensitive adhesive composition includes acrylate or methacrylate functionality. A method of making the hybrid composition includes polymerizing the ethylenically unsaturated monomer and the silicon-containing pressure sensitive adhesive composition in the presence of the initiator.Type: ApplicationFiled: November 29, 2011Publication date: May 10, 2012Inventors: Gary Lee Loubert, Tiffany Anne Menjoulet, Timothy Paul Mitchell, Xavier Jean-Paul Thomas
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Patent number: 8173155Abstract: The present invention relates an adhesive patch comprising a backing layer and an adhesive layer that contains a drug, wherein the adhesive layer contains a mixed adhesive base containing a hydrocarbon rubber and a silicon-containing polymer. The adhesive patch of the invention shows extremely superior skin absorbability of a drug in a preparation, reduced skin irritation, and excellent aging stability of the drug in the preparation, and can achieve easiness of drug-taking methods and improvement in compliance.Type: GrantFiled: May 31, 2005Date of Patent: May 8, 2012Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Takashi Yasukochi, Tetsuro Tateishi, Naruhito Higo
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Patent number: 8173156Abstract: An anti-inflammatory-containing plaster is provided. The anti-inflammatory-containing plaster may include, e.g., a styrene-isoprene-styrene block copolymer, a high molecular weight polyisobutylene, a low molecular weight polyisobutylene, a tackifier, a plasticizer, a dispersant, and an anti-inflammatory having a carboxyl group or a salt thereof. However, the anti-inflammatory-containing plaster does not contain L-menthol. The anti-inflammatory-containing plaster has medicament release rates of 20-64% by mass and 40-93% by mass at one hour and three hours, respectively.Type: GrantFiled: June 10, 2009Date of Patent: May 8, 2012Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Yasuhiro Ikeura, Miyuki Shinmura
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Patent number: 8153151Abstract: Compositions and methods for controlling transdermal drug delivery, particularly of amine-functional and basic drugs, comprising a blend of a first silicone-based polymer having a reduced silanol concentration and a second silicone-based polymer have a substantial or high silanol concentration. The blend of such silicone-based polymers, particularly pressure-sensitive silicone adhesives, provides sufficient drug solubility and reduced initial drug delivery onset to permit a prolonged delivery duration at a substantially zero-order rate of delivery.Type: GrantFiled: September 29, 2008Date of Patent: April 10, 2012Assignee: Noven Pharmaceuticals, Inc.Inventor: David Houze
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Patent number: 8127926Abstract: A patch package structure which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, a peripheral area of the first sheet material having been sealed to a peripheral area of the second sheet material to constitute the package, and a patch disposed in the package; in which the patch includes a backing, a pressure-sensitive adhesive layer formed on at least one side of the backing, and a release liner which protects the pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having a weakening line for assisting a removal of the release liner; and in which the second sheet material has specific first protrudent part, second protrudent part, third protrudent part and elevated part in a central area thereof except the peripheral area thereof.Type: GrantFiled: December 22, 2009Date of Patent: March 6, 2012Assignee: Nitto Denko CorporationInventors: Katsuhiro Okada, Yoshihiro Iwao, Kensuke Matsuoka
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Publication number: 20120052111Abstract: Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.Type: ApplicationFiled: November 8, 2011Publication date: March 1, 2012Inventors: Kevin S. Marchitto, Stephen T. Flock
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Patent number: 8124122Abstract: Provided herein is a female hormone-containing patch wherein an active ingredient is highly soluble in a pressure-sensitive adhesive layer and the active ingredient is not adsorbed to a backing, and the patch per se can follow the irregularities on the skin surface or body movements. The patch is an external patch containing, as a female hormone, a follicular hormone estradiol and/or its derivative or a progestational hormone norethisterone and/or its derivative. The external patch comprises an acrylic pressure-sensitive adhesive containing 0.01 to 1% by weight of an isocyanate-based crosslinking agent as an essential ingredient.Type: GrantFiled: August 7, 2003Date of Patent: February 28, 2012Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Takaya Sugahara, Sadanobu Shirai, Masahiro Yamaji
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Publication number: 20120027840Abstract: The present invention provides an adhesive patch including a backing and a pressure-sensitive adhesive layer formed on at least one surface of the backing, in which (a) a surface of the pressure-sensitive adhesive layer has a logarithmic decrement, as determined by the rigid-pendulum free-damped oscillation method, in the range of 0.03 to 0.35, and (b) the pressure-sensitive adhesive layer has a maximum shear displacement in the range of 18 ?m to 1,000 ?m. The present invention further provides a patch preparation containing a drug. The adhesive patch and the patch preparation according to the present invention are reduced in skin irritation during wear.Type: ApplicationFiled: July 26, 2011Publication date: February 2, 2012Applicant: NITTO DENKO CORPORATIONInventors: Akinori HANATANI, Sachiko SAKAMOTO, Arimichi OKAZAKI, Hitoshi AKEMI
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Patent number: 8105624Abstract: Topical patch preparations that contain an odorless physiological cooling agent, and methods for using the same are provided. The subject topical patch preparations are made up of an adhesive gel composition that is present on a support, where the adhesive gel composition includes the odorless physiological cooling agent, a water-soluble polymer gel, water and a water holding agent. In using the subject topical patch preparations, the topical patch preparations are applied to a skin surface of a subject and maintained at the site of application for a period of time sufficient for an effective amount of the an odorless physiological cooling agent to be administered to the subject. The subject invention finds use in a variety of applications.Type: GrantFiled: December 16, 2005Date of Patent: January 31, 2012Assignee: Teikoku Pharma USA, Inc.Inventor: Jutaro Shudo
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Patent number: 8101216Abstract: The present invention relates to a skin patch comprising a matrix adhering to the skin and containing at least one active cosmetic substance and a combination with a skin wrapping to generate an effective compression for the treatment of cellulite and/or striae.Type: GrantFiled: March 29, 2006Date of Patent: January 24, 2012Assignee: Beiersdorf AGInventors: Soeren Jaspers, Carsten Hartkopf, Christian Gaede, Stefan Bodenschatz, Katharina Post, Jens Schulz, Karl-Heinz Woeller
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Patent number: 8092827Abstract: A medical non-crosslinked pressure-sensitive adhesive composition which not only has relatively high resistance to water during perspiration or the like and shows a sufficient skin adhesive force, but also can contain a large amount of a liquid plasticizer and hence have reduced skin-irritating properties. These compositions comprise an adhesive polymer A having a weight-average molecular weight of 500,000-1,000,000, an adhesive polymer B having a weight-average molecular weight of 1,000,000-1,500,000, and a liquid plasticizer, wherein the adhesive polymer A is a polymer obtained by copolymerizing one or more alkyl (meth)acrylates with N-vinyl-2-pyrrolidone and the adhesive polymer B is either a polymer obtained by the polymerization of one or more alkyl (meth)acrylates or a polymer obtained by copolymerizing one or more alkyl (meth)acrylates with one or more comonomers other than N-vinyl-2-pyrrolidone.Type: GrantFiled: April 26, 2005Date of Patent: January 10, 2012Assignee: Nitto Denko CorporationInventors: Keigo Inosaka, Takateru Muraoka
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Patent number: 8088965Abstract: Methods accelerate healing of a wound by applying a multilayer bandage to the wound. The multilayer bandage has a spun-bonded webbing comprising at least one partially or completely hydrolytically condensed silicon compound and a water-impervious or semi-permeable first membrane having at least one water-insoluble polymer. The webbing has a biologically degradable or biologically resorbable structure and is brought into direct contact with the wound by placing the webbing in or on the wound.Type: GrantFiled: October 1, 2009Date of Patent: January 3, 2012Assignee: Bayer Innovation GmbHInventors: Axel Thierauf, Iwer Baecker, Andreas Haisch
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Publication number: 20110318405Abstract: The present invention relates to a chemical combination and method for increasing delivery of Coenzyme Q10. The chemical combination comprises Coenzyme Q10 mixed with at least one chemical. The at least one chemical includes cyclic terpene containing essential oil(s) that permit unprecedented levels of Coenzyme Q10 to be made available for delivery and absorption, increasing bioavailability, as well as overcoming the previous limits. A transdermal patch including a layer containing Coenzyme Q10 is also provided.Type: ApplicationFiled: August 22, 2011Publication date: December 29, 2011Inventor: Charles Erwin
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Publication number: 20110311611Abstract: An adherent article with a first substrate, soluble or dispersible in aqueous solutions, with a first and second side, and an aqueous-insoluble second substrate disposed on at least a portion of the second side of the first substrate, optionally, with an adhesive applied to at least a portion of the first side of the first substrate, and a release liner positioned over a portion of the first substrate or adhesive to cover and protect at least a portion of the adhesive.Type: ApplicationFiled: June 22, 2010Publication date: December 22, 2011Inventors: Charlene Cheuk Ling Ng, John T. Ulman
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Patent number: 8080703Abstract: A dressing able to adhere to the skin and/or a wound for covering a portion of the anatomical surface of a living being and demonstrating considerably increased wearing time. The dressing has a backing layer and a layer of skin-friendly adhesive for adhering to the skin, and includes a pattern of connected indentations formed in a pattern that is not linear and which progresses in at least three main directions.Type: GrantFiled: November 25, 2003Date of Patent: December 20, 2011Assignee: Coloplast A/SInventor: Jan Marcussen
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Patent number: 8080261Abstract: Gel compositions that contain 1-dichloro-2,4-dinitrobenzene (DNCB) are provided. Embodiments of the subject gel compositions include DNCB, an organic solvent and a viscosity agent, wherein the organic solvent and viscosity agent are inert with respect to the DNCB. Also provided are methods for using the subject compositions and kits for use in practicing the subject methods.Type: GrantFiled: November 8, 2005Date of Patent: December 20, 2011Assignee: Teikoku Pharma USA, Inc.Inventor: Jutaro Shudo
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Patent number: 8075911Abstract: A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.Type: GrantFiled: August 20, 2007Date of Patent: December 13, 2011Assignee: Alza CorporationInventor: Robert M. Gale
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Patent number: 8071126Abstract: A percutaneous absorption type patch adapted to be applied to a skin surface of a patient. The percutaneous absorption type patch comprises: a stratum-corneum release member constituted from a sheet-like first supporting substrate and a pressure-sensitive adhesive layer laminated on the first supporting member; a medicinal-components administration member constituted from a sheet-like second supporting substrate, a medicinal-components retention layer laminated on the second supporting substrate, and a protect layer laminated on the medicinal-components retention layer; and a sheet-like handling member interposed between the stratum-corneum release member and the medicinal-components administration member. An edge portion of the handling member is coupled to or integrated with both the first supporting substrate and the protect layer.Type: GrantFiled: March 19, 2008Date of Patent: December 6, 2011Assignee: LINTEC CorporationInventors: Toru Sekiguchi, Kaname Nakahara, Toru Watanabe
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Patent number: 8062661Abstract: Methods of debriding a skin wound are provided. Embodiments of the subject methods include contacting the skin wound with a hydrogel patch debridement composition to debride the wound. Also provided are systems and kits for use in practicing the subject methods.Type: GrantFiled: December 1, 2004Date of Patent: November 22, 2011Assignee: Teikoku Pharma USA, Inc.Inventors: Larry J. Caldwell, Jutaro Shudo, Andris Adamovics
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Publication number: 20110268785Abstract: Propynylaminoindan (e.g., Rasagiline) transdermal compositions are provided. Aspects of the transdermal compositions include a matrix of the propynylaminoindan in a pressure sensitive adhesive comprising a carboxylated polymer. In some instances, the matrix further includes a cationic acrylic copolymer. Also provided are methods of using the transdermal compositions and kits containing the transdermal compositions.Type: ApplicationFiled: March 21, 2011Publication date: November 3, 2011Inventors: Jianye Wen, Richard Hamlin
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Publication number: 20110262523Abstract: The present invention provides a medical adhesive tape comprising a non-woven fabric substrate of a metallocene polypropylene copolymer; and a medical pressure-sensitive adhesive coated on at least one side of said substrate. A medical article comprising a medicament and the medical adhesive tape of the invention is also provided.Type: ApplicationFiled: October 20, 2009Publication date: October 27, 2011Inventors: Dunshen . Zhu, ShiMing Zhou, Ting Fan, Grace L. Ho, Dong Wu