Gas Produced In Situ By Chemical Reaction Patents (Class 424/44)
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Patent number: 6689339Abstract: A carbon dioxide-containing viscous composition wherein carbon dioxide bubbles are retained in an aqueous viscous composition. Use of the composition makes it possible to treat or ameliorate itching accompanying mucocutaneous diseases or mucocutaneous disorders, mucocutaneous injury, dental diseases, skin ulcer, cryesthesia and numbness caused by peripheral circulatory disorders, musculoskeletal diseases, nervous system diseases, keratosis, constipation, unwanted hair re-growing after depilation, cosmetic troubles in the skin or hair, partial obesity, etc. while exerting little side effects.Type: GrantFiled: August 17, 2000Date of Patent: February 10, 2004Assignee: Medion Research Laboratories Inc.Inventors: Masaya Tanaka, Masato Hiki
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Publication number: 20030215397Abstract: A method of treating isomorphic diseases of the skin of mammals, to reduce the lesions or roughing of the skin surface resulting from such diseases, the method comprising topically applying to the skin of a mammal suffering from the skin disease several doses of an effective amount of a liquid composition containing a clinically effective concentration of a fatty acid ester of an alcohol, the ester comprising a total of from about 10 to about 35 carbon atoms, and a carrier liquid, the carrier liquid comprising water and a volatile parafinnic alcohol having up to four (4) carbon atoms, the proportion of water in the carrier liquid being from 0 to about 75% by volume, and further comprising a surfactant in the amount of up to about 0.4% by wt. of the total composition, the carrier liquid being present in an amount of from about 0 to about 60% by vol. of the total liquid composition, the ester being dispersed with any carrier liquid present.Type: ApplicationFiled: May 12, 2003Publication date: November 20, 2003Inventor: Patricia W. Noah
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Publication number: 20030215396Abstract: The present invention relates to pharmaceutical preparations in the form of aqueous solutions for the production of propellant-free aerosols.Type: ApplicationFiled: April 17, 2003Publication date: November 20, 2003Applicant: Boehringer Ingelheim Pharma KGInventors: Bernhard Freund, Bernd Zierenberg
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Patent number: 6620433Abstract: The new galenic formulation of paracetamol is comprised of a base mixture of paracetamol and citric acid in a proportion of 85:15 to 90:10 w/w among other pharmaceutically acceptable components, in an exsiccation state corresponding to a water activity of less than 0.6 and it is in the form of a powder, granulate or tablet. The process comprises obtaining said exsiccated base mixture up to a water activity of less than 0.6 in order to obtain a powder, that can be granulated in order to obtain a granulate dispersible and soluble in water, whose granulate can also be compressed in order to obtain a tablet dispersible and soluble in water. Said new formulation is useful in human and veterinary medicine.Type: GrantFiled: July 3, 2002Date of Patent: September 16, 2003Assignee: Laboratorios Belmac, S.A.Inventors: Luis Carvajal Martín, Juan Carlos Asensio Asensio, Francisco Javier Sevilla Tirado
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Publication number: 20030170182Abstract: This invention relates to a topical spray preparation for burn treatment and microbial infections on human being or animals. This non-aerosol preparation contains an antimicrobial drug, i.e., silver sulfadiazine, as is dispersed or solubilized in a cream or lotion base matrix which can be sprayed directly from a common trigger spray device. The key component of the matrix can be characterized by it having a suitable molecular weight polymer of cross-linked acrylic acid, such as Carbomers or non-ionic surfactants such as polyoxyethylene alkyl ethers, or any combination of the above materials.Type: ApplicationFiled: April 1, 2003Publication date: September 11, 2003Applicant: Sage Pharmaceuticals, Inc.Inventor: Jivn-Ren Chen
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Patent number: 6610312Abstract: A wiping article is provided which includes an effervescent cleanser composition held within a pouch formed from a first and second substrate sheet. At least one of the substrate sheets must be water permeable. The effervescent composition is an intimate mixture of an acid material such as citric acid and an alkaline material such as sodium bicarbonate. Water contact causes the combination to effervesce. A dry surfactant such as sodium cocoyl isethionate in contact with the water and effervescing carbon dioxide results in a highly pleasant sudsing system. Skin benefit agents may be included within the composition. The effervescent action may improve deposition of the skin benefit agents onto the skin.Type: GrantFiled: February 15, 2001Date of Patent: August 26, 2003Assignee: Unilever Home & Personal Care USA, Division of Conopco, Inc.Inventors: Linda Farrell, Craig Stephen Slavtcheff, Alexander Paul Znaiden, Paul Vinski
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Patent number: 6605304Abstract: A particle including anions dispersed throughout an amorohous, paracrystalline or crystalline solid solution, the anions being capable of reacting with hydronioum ions to generated a gas. The particle can be incorporated into a power capable of generating and releasing a gas after hydrolysis of an acid releasing agent.Type: GrantFiled: August 21, 1998Date of Patent: August 12, 2003Assignees: Bernard Technologies, Inc., Southwest Research InstituteInventors: Stephen T. Wellinghoff, Joel J. Kampa, Sumner A. Barenberg, Peter N. Gray, Michael D. Lelah
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Patent number: 6602520Abstract: Rapidly disintegrating preparations containing at least one active pharmaceutical ingredient and at least one excipient can be obtained by a simple process in which at least the predominant part of the complete composition of the ingredients for the preparation to be produced is granulated, the resulting granules and, where appropriate, the remainder of the ingredients are shaped in the presence of liquid virtually without pressure, and the resulting shaped articles are dried.Type: GrantFiled: January 3, 2002Date of Patent: August 5, 2003Assignee: Bayer AGInventors: Marco Schroeder, Klaus-Jürgen Steffens
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Patent number: 6589507Abstract: The invention relates to antacid preparations comprising the following constituents: (i) an acid-binding active constituent (antacid) or a mixture of such active constituents, (ii) an effervescent mixture that releases CO2, (iii) a polymeric surfactant as foam-forming agent or a mixture of such surfactants, (iv) a swellable and gel-forming polymer or a mixture of such polymers, and (v) optionally conventional auxiliary substances, as well as a process for the production of such antacid preparations. In a particularly preferred embodiment the antacid preparation is formulated in the form of a chewable tablet. The antacid preparations according to the invention are suitable for the symptomatic treatment of duodenal ulcers, gastric ulcers, as well as heartburn and acid-caused gastric disorders such as hyperacidic gastritis.Type: GrantFiled: August 13, 2001Date of Patent: July 8, 2003Assignee: DR. Regenold GmbHInventor: Kurt H. Bauer
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Patent number: 6585957Abstract: A medicinal formulation is disclosed. The formulation comprises (a) a protein or peptide medicament; (b) a fluid carrier for containing said medicament; and a stabilizer selected from an amino acid, a derivative thereof or a mixture of the foregoing.Type: GrantFiled: October 30, 2000Date of Patent: July 1, 2003Assignee: Aeropharm Technology IncorporatedInventors: Akwete L. Adjei, Yaping Zhu, John Z. Sun, Simon Stefanos
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Patent number: 6576810Abstract: A toilet training article in the form of a toilet training pad containing an effervescent agent is disclosed. The toilet training pad, which may be an insertable pad or integrated directly into an undergarment, contains an effervescent agent which releases gas upon being contacted by urine. The effervescent agent may be in the form of a compound containing a substantially inert gas, or may be a combination of compounds that, upon being contacted by urine, produce a gas.Type: GrantFiled: October 25, 2000Date of Patent: June 10, 2003Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Richard L. Underhill, Marsha M. Malone, Bernard J. Minerath, III, Beth A. Lange, Duane G. Krzysik, David W. Koenig, Kimberly M. Bleck
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Patent number: 6565833Abstract: This invention relates to a medicinal aerosol formulation and more particularly, to a medicinal aerosol formulation containing a troglitazone medicament and a fluid carrier.Type: GrantFiled: October 31, 2000Date of Patent: May 20, 2003Assignee: Aeropharm Technology IncorporatedInventors: Anthony J. Cutie, Akwete L. Adjei
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Patent number: 6565881Abstract: The present invention relates to a new type of solid balneological preparations for cosmetic, hygienic and therapeutic use, which has both the properties of a solid bath additive and those of liquid products, and is characterized especially by the addition of lipid components, vesicle forming lipids, tensides and, in some cases, mineral salts. Active components, adjuvants such as stabilizers, adsorbing substances, lubricants as well as smoothing and breakdown promoting agents may also be contained therein.Type: GrantFiled: July 13, 1998Date of Patent: May 20, 2003Assignee: Marz Pharma GmbH & Co.KgaAInventors: Eberhard Nürnberg, Kerstin Jerzembek, Rolf D. Beutler, Jürgen Ebinger, Ruth Weis
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Patent number: 6562952Abstract: A process for forming small micron-sized (1-10 &mgr;m) protein particles is provided wherein a protein, a solvent system for the protein and an antisolvent for the protein solvent system are contacted under conditions to at least partially dissolve the protein solvent system in the antisolvent, thereby causing precipitation of the protein. The solvent system is made up of at least in part of a halogenated organic alcohol, most preferably 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). Preferably, a solution of the protein in the solvent system is sprayed through a nozzle into a precipitation zone containing the antisolvent (preferably CO2) under near- or supercritical conditions.Type: GrantFiled: October 31, 2000Date of Patent: May 13, 2003Assignee: The University of KansasInventors: Roger A. Rajewski, Bala Subramaniam, William K. Snavely, Fenghui Niu
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Patent number: 6559110Abstract: A bar soap preparation having enhanced antibacterial and microbial properties which contains between 0.1 weight % and 95 weight % of at least one anionic surfactant; and at least one acidifying agent present in an amount sufficient to impart a pH of below 5.0. The bar soap provides microbial protection resulting from its rapid microbicidal action.Type: GrantFiled: August 23, 2001Date of Patent: May 6, 2003Inventor: John A. Lopes
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Patent number: 6548049Abstract: This invention relates to a medicinal aerosol formulation and more particularly, to a medicinal aerosol formulation containing pioglitazone medicament and a fluid carrier.Type: GrantFiled: October 31, 2000Date of Patent: April 15, 2003Assignee: Aeropharm Technology IncorporatedInventors: Anthony J. Cutie, Akwete L. Adjei, Frederick A. Sexton
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Patent number: 6540983Abstract: This invention relates to a medicinal aerosol formulation and more particularly, to a medicinal aerosol formulation containing a &bgr;-cell hypoglycemic agent and a fluid carrier.Type: GrantFiled: October 31, 2000Date of Patent: April 1, 2003Assignee: Aeropharm Technology IncorporatedInventors: Akwete L. Adjei, Anthony J. Cutie, John Z. Sun, Fred Sexton
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Patent number: 6540982Abstract: This invention relates to a medicinal aerosol formulation and, more particularly, to a medicinal aerosol formulation an insulin combination and a fluid carrier.Type: GrantFiled: October 30, 2000Date of Patent: April 1, 2003Assignee: Aeropharm Technology IncorporatedInventors: Akwete L. Adjei, Anthony J. Cutie
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Patent number: 6534016Abstract: The present invention is an additive preparation which contains an additive, an organic acid, a metal carbonate compound, and a surfactant agent which is capable of rendering the surface of a collection device to have properties that cause the surface to repel the adsorption of components of a body fluid sample. The preparation effervesces when in contact with a body fluid sample, thereby efficiently dispersing the additive and surfactant in a body fluid sample.Type: GrantFiled: November 21, 2000Date of Patent: March 18, 2003Inventors: Richmond Cohen, Ajit N. Dastane
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Publication number: 20030026837Abstract: An effervescent solid composition of matter is provided, which comprises, as an active component, a substance selected from chitosan, its derivatives and salts thereof and a second component capable of releasing CO2 in an acidic environment.Type: ApplicationFiled: April 12, 2002Publication date: February 6, 2003Inventors: Torbjorn Mathisen, Marcus Back, Asa Hellman
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Patent number: 6511650Abstract: This invention is directed to a new approach to form porous hydrogel materials by first creating gas pockets in the gel and then removing this gas. The removal of the gas creates a porous material, and the initial incorporation of sufficient gas allows one to create a material with an open, interconnected pore structure. Advantageous features of the resulting materials, in addition to their interconnected pore structure, may include that the pore structure is maintained over extended time periods and that the gels maintain a high mechanical integrity that allows seeding with cells and implantation without destruction or compression of the material.Type: GrantFiled: April 18, 2002Date of Patent: January 28, 2003Assignee: The Regents of the University of MichiganInventors: Petra Eiselt, Craig Halberstadt, David Mooney, Julia Yeh, Rachel Latvala, Jon A. Rowley
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Patent number: 6503481Abstract: A composition used in combination with an electrohydrodynamic device capable of delivering an active ingredient to the aerodigestive system of the user. The composition comprises three or optionally four basic components: an active ingredient; a carrier material in which the active ingredient may be dissolved, suspended, or emulsified; an aerosol properties adjusting material which provides the composition with the physical characteristics required to create an aerosol cloud by electrostatic or electrohydrodynamic means; and optionally at least one excipient that further adjusts, preserves, stabilizes, or enhances the overall performance of the composition.Type: GrantFiled: May 2, 2000Date of Patent: January 7, 2003Assignee: BattellePharma, Inc.Inventors: Rachel M. Thurston, James D. Browning, Praful K. Shah, Michael E. Placke
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Publication number: 20030003147Abstract: An effervescent formulation of alendronate contains an acid source, a carbonate source, a binder, a lubricant and optionally, flavoring agents, colorants and sweeteners.Type: ApplicationFiled: July 9, 2002Publication date: January 2, 2003Applicant: Merck & Co., Inc.Inventors: Ashok V. Katdare, Colin R. Gardner, Kenneth A. Kramer
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Publication number: 20020187104Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.Type: ApplicationFiled: May 31, 2002Publication date: December 12, 2002Applicant: WyethInventors: Rebecca H. Li, Howard J. Seeherman
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Patent number: 6491896Abstract: A denture cleanser composition comprising polybutene, with a molecular weight of about 300 to about 3000, an effervescence generator and a bleaching agent. Optionally, denture cleanser compositions may further comprise tablet binders, organic peroxyacid bleach precursors, surfactants including a dimethicone copolyol, lipophilic compounds such as flavorants and coolants, chelating agents, and other therapeutic and cosmetic active agents.Type: GrantFiled: February 28, 2002Date of Patent: December 10, 2002Assignee: The Proctor & Gamble CompanyInventors: Jayanth Rajaiah, Lisa Catron Ernst, Ann Maria Case, Thinh Nguyen Ha, William Michael Glandorf, Christopher Robert Mayer
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Patent number: 6488961Abstract: Disclosed here are effervescent granules having a controllable rate of effervescence. In some embodiments, the such granules comprise an acidic agent, an alkaline agent, a pharmacologically active agent, hot-melt extrudable binder capable of forming a eutectic mixture with the acidic agent and, optionally, a plasticizer. The effervescent granules are made by a hot-melt extrusion process. The present invention also provides a thermal heat process for preparing a pharmacologically active agent containing effervescent granule. In certain aspects, the granules contain pharmacologically active agents such as narcotics, antidiarrheal agents, antiviral agents, anxiolytic agents, a cholesterol lowering agent, an alpha adrenergic blocking agent, a phenanthrene derivative. By way of example, some of the narcotics that may be included in the granules and in the process of preparing the granules include, by way of example: phenanthrene derivatives (e.g., morphine sulfate), and morphine derivatives (e.g.Type: GrantFiled: December 21, 1999Date of Patent: December 3, 2002Assignee: Ethypharm, Inc.Inventors: Joseph R Robinson, James W. McGinity
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Publication number: 20020155067Abstract: The present invention provides a hydrostatic delivery system comprising a hydrostatic couple and an agent of interest. The hydrostatic couple comprises, at least one hydrodynamic fluid-imbibing polymer, and at least one hydrostatic pressure modulating agent. This delivery system has the ability to control the release of one or more agent of interest within a fluid environment following zero-order kinetics.Type: ApplicationFiled: April 2, 2002Publication date: October 24, 2002Inventor: Alexander MacGregor
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Patent number: 6468507Abstract: A non-aqueous medicinal aerosol formulation comprising rosiglitazone maleate, a fluid carrier, and an amino acid stabilizer. The aerosol formulation may also include drug combination formulations comprising rosiglitazone maleate and a second anti-diabetic medicament.Type: GrantFiled: October 31, 2000Date of Patent: October 22, 2002Assignee: Aeropharm Technology, Inc.Inventors: Anthony J. Cutie, Akwete L. Adjei, Frederick A. Sexton
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Patent number: 6468994Abstract: The invention provides finely divided, substantially crystalline particles of budesonide characterized in that they are substantially smooth and having a BET value of from 1 to 4.5 m2/g, a process for their preparation, a pharmaceutical composition comprising said particles, the use of said particles in the treatment of and in the manufacture of a medicament for use in the treatment of respiratory disorder, and a method of treatment of respiratory disorders by administration of said particles to a host in need of such treatment.Type: GrantFiled: November 6, 2001Date of Patent: October 22, 2002Assignee: AstraZeneca ABInventors: Mikael Bisrat, Saeed Moshashaee
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Patent number: 6464959Abstract: A non-aqueous medicament aerosol formulation comprising troglitazone, or a derivative thereof, a fluid carrier, and an amino acid stabilizer. The aerosol formulation may also include drug combination formulations comprising troglitazone and a second anti-diabetic medicament.Type: GrantFiled: October 31, 2000Date of Patent: October 15, 2002Assignee: Aeropharm Technology IncorporatedInventors: Anthony J. Cutie, Akwete L. Adjei
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Patent number: 6461638Abstract: Pharmaceutical compositions for rectal administration comprising an effervescent mixture comprising sodium bicarbonate and glutamic acid or pyroglutamic acid with at least one diluent adapted for rectal administration, said mixture being effervescent.Type: GrantFiled: May 25, 1999Date of Patent: October 8, 2002Assignee: Techni-PharmaInventor: Axelle Note-Simonnard
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Publication number: 20020127184Abstract: An effervescent sub-lingual type composition, optionally in tablet form, comprising at least one active ingredient, one ore more fruit acids, and one or more effervescing alkalis, wherein at least the acid component(s) have been coated with protective layer of polydimethylsiloxane that substantially minimizes contact between the acid(s) and atmospheric moisture until the composition is purposely mixed with water or is used sub-lingually. A method of preparation of the effervescent compositions is also dislcosed.Type: ApplicationFiled: August 27, 2001Publication date: September 12, 2002Inventor: James Selim
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Publication number: 20020127183Abstract: An effervescent compound is disclosed which includes a solvent and an effervescent system. The solvent may be both hydrophilic and have low solubility with organic effervescent ingredients. The solvent may include a glycol ether, for example, but not limited to, 2-butoxyethanol. The effervescent system used in the effervescent compound may be, for example, but is not limited to, expanded sodium perborate or a mixture of sodium bicarbonate, sodium carbonate, and an acid. The effervescent compound may further include any one, or all, or any combination of the following ingredients: surfactants, bleaching compositions, anti-redeposition agents, binders, lubricants, colors, fragrances, and/or optical brighteners. Also disclosed is a method for making an effervescent compound, including the steps of providing a solvent, providing an effervescent system in powder form, and mixing the solvent with the effervescent system, thereby producing a free-flowing effervescent compound.Type: ApplicationFiled: March 9, 2001Publication date: September 12, 2002Inventors: Richard A. DeSenna, Hilton G. Dawson, Ryan Giffin Moore, Kenneth Scott Wiley
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Publication number: 20020122772Abstract: A self foaming composition comprising: (I) a surfactant mixture comprising (a) at least one anionic surfactant; (b) at least one amphoteric surfactant; and (c) optionally at least one nonionic surfactant; and (II) at least one self foaming agent. The composition is in the form of a liquid crystalline structure and wherein the ratio of (a) to (b) to (c) is selected such that when the surfactant composition is mixed with the self foaming agent a gel consistency is obtained. The cleansing composition is useful in the bath and the shower, as a facial cleanser, and as a shampoo.Type: ApplicationFiled: July 13, 2001Publication date: September 5, 2002Inventors: Elvin Lukenbach, Karine Dupre, Susan Niemiec
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Patent number: 6432446Abstract: A method of treating disorders involving the urethrogentical tract by administering to pateints in need therof therapeutically effective amounts of the desethyl metabolite of oxybutynin and/or the optically active isomers thereof, which are free from said cardiac side effect of oxybutynin, while maintaining the therapeutic activities of oxybutynin or the optically active isomers thereof.Type: GrantFiled: February 1, 2001Date of Patent: August 13, 2002Assignee: Bridge Pharma, Inc.Inventor: A. K. Gunnar Aberg
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Patent number: 6428800Abstract: A method for treating wounds including contacting a wound with an effective wound healing amount of bioactive glass and topical antibiotic and composition for the accelerated healing of wounds and burns including particulates of bioactive glass and at least one topical antibiotic.Type: GrantFiled: October 1, 1998Date of Patent: August 6, 2002Assignee: USBiomaterials CorporationInventors: David C. Greenspan, Jon K. West
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Patent number: 6428770Abstract: The present invention relates to a solid preparation for oral hygiene, which comprises (a) 15 to 90 wt. % of a bubbling component and (b) 0.001 to 10 wt. % of an orally-usable medicinal component at an (a):(b) ratio ranging from 10:1 to 1000:1. Use of the preparation brings about a drastic improvement in the drug efficacy and moreover, breath is freshened by bubbling.Type: GrantFiled: June 2, 2000Date of Patent: August 6, 2002Assignee: Kao CorporationInventors: Shigeto Kayane, Yoshitaka Yano, Shinji Kiji, Keiko Masuki, Hidetake Fujinaka, Yasuteru Eguchi, Mitsuyoshi Kashiwagi
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Publication number: 20020090343Abstract: An effervescent compound is disclosed which includes a liquid ingredient, an effervescent system and optionally a solvent. The solvent may be either hydrophilic or hydrophilic, and may have low solubility with effervescent ingredients. The solvent may include an alcohol, a glycol or a glycol ether, for example, but not limited to, 2-butoxyethanol. The effervescent system used in the effervescent compound may be, for example, but not limited to, an expanded perborate salt, anhydrous, or a mixture of an expanded perborate salt, anhydrous, and oxoborate or an acid and one or more of sodium bicarbonate, sodium carbonate, potassium bicarbonate and potassium carbonate. The effervescent compound may further include any one, or all, or any combination of the following ingredients: surfactants, bleaching compositions, anti-redeposition agents, binders, lubricants, colors, fragrances, corrosion inhibitors, disinfectants, pesticides, fertilizers and/or optical brighteners.Type: ApplicationFiled: August 17, 2001Publication date: July 11, 2002Applicant: Chemlink Laboratories, LLCInventors: Ryan Giffin Moore, Hilton G. Dawson, Richard A. DeSenna, Kenneth Scott Wiley
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Publication number: 20020081264Abstract: An effervescent compound is disclosed which includes a liquid ingredient, an effervescent system and optionally a solvent. The solvent may be both hydrophilic and have low solubility with effervescent ingredients. The solvent may include an alcohol, a glycol or a glycol ether, for example, but not limited to, 2-butoxyethanol. The effervescent system used in the effervescent compound may be, for example, but not limited to, an expanded perborate salt, anhydrous, or a mixture of an expanded perborate salt, anhydrous, and one or more of sodium bicarbonate, sodium carbonate, potassium bicarbonate and potassium carbonate. The effervescent compound may further include any one, or all, or any combination of the following ingredients: surfactants, bleaching compositions, anti-redeposition agents, binders, lubricants, colors, fragrances, and/or optical brighteners. Further disclosed is a method of producing the expanded perborate salt, anhydrous.Type: ApplicationFiled: May 15, 2001Publication date: June 27, 2002Inventors: Ryan Giffin Moore, Hilton G. Dawson, Richard A. DeSenna, Kenneth Scott Wiley
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Publication number: 20020071809Abstract: The pharmaceutical compositions of the present invention comprise orally administerable dosage forms that use effervescence as a penetration enhancer for drugs known, or suspected, of having poor bioavailability. Effervescence can occur in the stomach, once the tablet or other dosage form is ingested. In addition to effervescence in the stomach, or as alternative technique, by the use of appropriate coatings and other techniques, the effervescence can occur in other parts of the gastrointestinal tract, including, but not limited to, the esophagus, duodenum, and colon. The site of effervescence and drug release is chosen to correspond with the segment of the gastrointestinal tract displaying maximal absorption of the formulated drug, or to gain some other therapeutic advantage.Type: ApplicationFiled: October 29, 2001Publication date: June 13, 2002Inventors: S. Indiran Pather, Joseph R. Robinson, Jonathan D. Eichman, Rajendra K. Khankari, John Hontz, Sangeeta V. Gupte
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Publication number: 20020068038Abstract: The present invention relates to a foaming tablet for cleaning the oral cavity, more particularity, a foaming tablet prepared by mixing and tabletting the oral cavity cleaning components and foaming agent to be used for the efficient cleaning agent of oral cavity.Type: ApplicationFiled: November 5, 2001Publication date: June 6, 2002Inventor: Joo Hwan Yang
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Publication number: 20020051752Abstract: A pharmaceutical formulation in the form of a fast dissolving tablet comprising an active ingredient, sodium glycine carbonate and an acid capable of reacting rapidly with sodium glycine carbonate to release carbon dioxide.Type: ApplicationFiled: August 20, 2001Publication date: May 2, 2002Applicant: Chiesi Farmaceutici S.p.A.Inventors: Paolo Chiesi, Paolo Ventura, Rosa Mezzadri, Gaetano Brambilla, Daniela Acerbi
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Patent number: 6375986Abstract: Disclosed are solid dose nanoparticulate compositions comprising a poorly soluble active agent, at least one polymeric surface stabilizer, and dioctyl sodium sulfosuccinate (DOSS). The solid dose compositions exhibit superior redispersibility of the nanoparticulate composition upon administration to a mammal, such as a human or animal. The invention also describes methods of making and using such compositions.Type: GrantFiled: September 21, 2000Date of Patent: April 23, 2002Assignee: Elan Pharma International Ltd.Inventors: Niels P. Ryde, Stephen B. Ruddy
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Publication number: 20020039558Abstract: A wiping article is provided which includes an effervescent cleanser composition held within a pouch formed from a first and second substrate sheet. At least one of the substrate sheets must be water permeable. The effervescent composition is an intimate mixture of an acid material such as citric acid and an alkaline material such as sodium bicarbonate. Water contact causes the combination to effervesce. A dry surfactant such as sodium cocoyl isethionate in contact with the water and effervescing carbon dioxide results in a highly pleasant sudsing system. Skin benefit agents may be included within the composition. The effervescent action may improve deposition of the skin benefit agents onto the skin.Type: ApplicationFiled: September 10, 2001Publication date: April 4, 2002Applicant: Chesebrough-Pond's Co.Inventors: Linda Farrell, Craig Stephen Slavtcheff, Alexander Paul Znaiden, Paul Vinski
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Publication number: 20020037255Abstract: A packaged effervescent product is provided which includes a sachet surrounded by an outer package film sealing the sachet against water vapor transmission. The sachet is a cosmetic article which includes an effervescent cleansing composition of an acid material such as citric add and an alkaline material such as sodium bicarbonate. The composition is held within the sealed sachet or pouch. At least one wall of the pouch is water permeable. The outer package film is formed of a material which must have a breathability for carbon dioxide. Any carbon dioxide generated during storage is thereby allowed to slowly diffuse into the atmosphere while still minimizing the amount of water which may enter the package.Type: ApplicationFiled: May 14, 2001Publication date: March 28, 2002Applicant: Unilever Home & Personal Care USA, Division of Conopco, Inc.Inventors: Natalie Charambura, Paul Roland Bergquist, Craig Stephen Slavtcheff
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Patent number: 6355609Abstract: Nutritional solutions and methods of making same are disclosed. The solutions include protein, lipid, and a carbohydrate source including high amylose starch and guar gum.Type: GrantFiled: April 14, 1999Date of Patent: March 12, 2002Assignee: Nestec S.A.Inventors: Chandrasekhara Reddy Mallangi, Eileen Fuchs, Kjerstin Carlsson, Axel Syrbe, Reinhard Behringer
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Patent number: 6355246Abstract: The present invention provides an isolated feline calicivirus and mutants thereof, which were isolated from the urine of a cat with lower urinary tract disorder. The present invention further provides nucleic acid clones of the virus, in particular, a clone which encodes the capsid antigen of the virus. The present invention is useful for providing a live or killed virus vaccine comprising the virus or mutants thereof, a subunit vaccine comprising the capsid antigen of the virus, a nucleic acid vaccine encoding the capsid antigen of the virus, and a recombinant virus vector vaccine encoding the capsid antigen of the virus. The present invention also provides a method for isolating feline calicivirus from urine and an assay for diagnosing cats infected with feline calicivirus.Type: GrantFiled: June 8, 2000Date of Patent: March 12, 2002Assignee: Board of Trustees of Michigan State UniversityInventors: John M. Kruger, Roger K. Maes, Aivars Vilnis
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Publication number: 20020025299Abstract: An aerosol solution composition for use in an aerosol inhaler comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler. The composition is stabilized by using a small amount of mineral acid and a suitable can having part or all of its internal metallic surfaces made of stainless steel, anodized aluminium or lined with an inert organic coating.Type: ApplicationFiled: May 21, 2001Publication date: February 28, 2002Applicant: Chiesi Farmaceutici S.p.A.Inventors: David Lewis, David Ganderton, Brian Meakin, Gaetano Brambilla, Alessandra Ferraris
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Patent number: 6346523Abstract: The invention provides finely divided, substantially crystalline particles of budesonide characterized in that they are substantially smooth and having a BET value from 1 to 4.5 m2/g, process for their preparation, a pharmaceutical composition comprising said particles, the use of said particles in the treatment of and in the manufacture of a medicament for use in the treatment of a respiratory disorder, and a method of treatment of respiratory disorders by administration of said particles to a host in need of such treatment.Type: GrantFiled: June 18, 1998Date of Patent: February 12, 2002Assignee: AstraZeneca ABInventors: Mikael Bisrat, Saeed Moshashaee
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Patent number: 6342242Abstract: Seaweed harvested from the ocean when ground as an intact meal or exposed to alkaline hydrolsis extraction procedure resulting in a water soluble form provides a feed ingredient with mineral composition and plant growth regulating activity when included as a pasture treatment or feed ingredient for mammals and poultry, resulting in enhanced immune function, enhanced health, weight gain, and meat grade quality. Steers grazing seaweed extract treated forage continued to exhibit enhanced immune function after entering feedlot phase finishin with no seaweed extract diet supplement.Type: GrantFiled: February 27, 1998Date of Patent: January 29, 2002Assignees: Texas Tech University, Virginia Tech Intellectual Properties, Inc.Inventors: Vivien Gore Allen, Kevin R. Pond, Korinn E. Saker, Joseph P. Fontenot