Abstract: The present invention discloses tablet formulations, produced by dry roller compaction comprising compacted granulates of a mixture of a medicament and an intra-granular disintegrant. The granulates are compacted together into a tablet with an extra-granular disintegrant, an optional extragranular lubricant and excipients.

Abstract: An effervescent formulation of alendronate contains an acid source, a carbonate source, a binder, a lubricant and optionally, flavoring agents, colorants and sweeteners.

Abstract: The present invention is a method of preparing rapidly dissolving comestible units such as tablets. The present invention also includes an apparatus for making the comestible units and the units themselves. The product prepared in accordance with the present invention can include active ingredients and is capable of dissolving in the mouth of the consumer within several seconds. The unit dosage forms prepared in accordance with the present invention are particularly useful as antacids and as a delivery vehicle for biologically active ingredients, especially those which are ideally combined with antacid ingredients in order to ameliorate the effects of antacid environment.

Abstract: Effervescent composition comprising in synergetic quantities: iodinated polyvinylpyrrolidone (IPVP) at least one effervescent agent, and at least one disintegrating agent. It may be presented in the form of powder, granules or tablets.

Abstract: The invention provides a new water soluble lubricant combination which facilitates the production of tablets. The combination of glyceryl behenate and fumaric acid is useful as a lubricant, particularly in tablet compositions containing ingredients where rapid dissolution in an aqueous environment is desired for activity or desired for aesthetic purposes. This lubricant combination has fewer limitations and improved functionality in comparison to standard lubricants presently known. In addition, the lubricants provided may be used with known hydrophobic lubricants to decrease the amount of the hydrophobic lubricant required for lubrication.

Abstract: This invention provides a taste masking composition composed of clove oil and either supportive flavor components or calcium carbonate. This taste masking composition has been found to be particularly useful to mask unpalatable medicinals in formulations which are intended to be chewed, dissolve in the mouth prior to ingestion or ingested in solution.

Abstract: A pharmaceutical formulation includes a hydrophobic active substance, an effervescent system, and at least two surfactants. Each of the surfactants is selected from a different group selected from the following three groups: phospholipids, polysorbates, and esterified sugars. The formulations provide improved dispersion and bioavailability of hydrophobic active substances.

Abstract: A process for producing a granulated material from a powder mixture containing at least two components, one of which is in crystal or crystalline form and at least one contains water of crystallization and/or is reactive, granulation is carried out in an inclined drum. Powder is fed in at one end and granulate removed at the other, after being transported inside the drum for a desired period while the drum is rocked in a way which largely eliminates shear forces. A quantity of liquid at least approximately equal to the quantity of water of crystallization present and sufficient for the formation of a superficially active solution adhesive is released inside the drum, where appropriate by partial reaction of the reactive component(s), after which the powder mixture components are granulated by surface adhesion.

Abstract: An effervescent composition comprising a core-shell powder consisting of a fine granular core spray-coated with a liquid mixture containing a water-soluble polymer such as hydroxypropylcellulose or hydroxypropylmethylcellulose, and at least one physiologically active substance, especially an acid-sensitive drugs, and enteric coating film, an effervescing component and an auxiliary effervescing agent which provides for controlled release of the physiologically active substance and in useful for preparing uniform solution or suspension having a refreshing sensation on ingestion.

Abstract: A non-aqueous liquid plaque adsorbent oral or effervescent dentifrice composition comprising a non-aqueous carbon dioxide source selected from bicarbonate salt, carbonate salt and mixtures thereof, a non-aqueous, water soluble acid source selected from organic acid, partial salt thereof and mixtures thereof, and a carrier adsorbent. Optionally, the composition can include flavoring agent, artificial, non-caloric sweetener, surface active agent, anti-bacterial agent, astringent agent, desensitizing agent, fluoride containing anti-caries agent, gelling agent, chloropyhyllin salt, coloring agent, hydrogen peroxide source and/or excipient. The effervescent dentifrice is preferably employed as one component of a kit also including a debriding product, a hydrogen peroxide product and a bicarbonate dentifrice, the components of the kit being used in combination on a daily basis to synergistically achieve enhanced preventative and remedial oral hygiene.

Abstract: A water soluble effervescent tablet formulation for preparing a disinfecting solution comprising a first tablet containing a bromide releasing agent and a second tablet containing a hypochlorite releasing agent.

Abstract: There is provided an improved, fast-melting solid dosage form which readily disintegrates when placed in the mouth. The solid dosage form preferably being a tablet comprising the following primary ingredients whose proportions are calculated as weight percent on the total weight of the tablet: (a) from about 30 to 50 weight percent, of a pharmaceutically acceptable active ingredient component; (b) an effervescent couple consisting of about 3 to 5 weight percent of an effervescence base about 3 to 5 weight percent of an effervescence acid suitable for achieving a gas evolving reaction with the effervescence base upon being contacted with an aqueous solution such as saliva; (c) about 40 to 50 weight percent of a pharmaceutically acceptable starch as a bulking and disintegrating agent; (d) about 3 to 5 weight percent of a tablet lubricant. Additionally, the tablet may comprise flavoring agents.

Abstract: The present invention comprises a tablet, and method for making such, which disintegrates or dissolves in a matter of just a few seconds once placed into the oral cavity. Generally, the method of the present invention comprises up to four steps. First, a porous particulate powder which will serve as the tablet support matrix is produced. In the second step, the pharmaceutical, for example an antihistamine, decongestant, or antibiotic is combined with the powder. Other additives may also be added to the mixture. In the third step the mixture is formed into a tablet. Finally, in the fourth step, a coating may be applied to the outer surface of the tablet to enhance the intactness and durability of the tablet.

Abstract: Provided is an improved, fast-melting solid dosage form which readily disintegrates when placed in the mouth. The solid dosage form preferably being a tablet comprising the following primary ingredients whose proportions are calculated as weight percent on the total weight of the tablet: (a) from about 30 to 50 weight percent, of a pharmaceutically acceptable active ingredient component; (b) an effervescent couple consisting of about 2 to 5 weight percent of an effervescence base about 2 to 5 weight percent of an effervescence acid suitable for achieving a gas evolving reaction with the effervescence base upon being contacted with an aqueous solution such as saliva; (c) about 35 to 50 weight percent of a pharmaceutically acceptable starch as a bulking and disintegrating agent; (d) about 0.04 to 1 weight percent of a starch degrading enzyme; and (e) about 2 to 5 weight percent of a tablet lubricant. Additionally, the tablet may comprise flavoring agents.

Abstract: Disclosed is a non-liquid oral dentifrice composition commonly in the form of powder or tablets which is characterized by an efficacious ratio of carbon dioxide source, xylitol, acid source and silicon dioxide.

Abstract: In accordance with this invention there is provided a granular product with an effervescent system which comprises acid-sensitive pharmaceutically active substances, such as, for example, betacarotene, cimetidine, ranitidine or cisapride, which is specially useful to prevent antacid action, having an acid-neutralizing capacity below about 5 meq, at a weight of about 1.6 to about 2.3 grams. The effervescent grains are made from carrier crystals of at least one solid, edible organic acid, preferably citric acid and/or tartaric acid, and are present as a granular product, separate from the pharmaceutically active substance, and are coated with at least one layer of a neutral substance which is soluble in water and/or alcohol and which is able to bring about a melting point depression of the acid grains at their surface, such as, for example, a water-soluble polymer, a polyalcohol, a carbohydrate and/or a hydrocolloid.

Abstract: A description is given of a pharmaceutical form for oral administration consisting of a two- or three-layers tablet, wherein at least one layer can rapidly swell by contact with biological and/or aqueous fluids, said swelling resulting in a considerable increase in the tablet volume. Said phenomenon determines a prolonged residence of the pharmaceutical form at the gastric level and therefore allows a slow release of the active ingredient from said pharmaceutical form to the stomach and/or the first tract of the intestine.

Abstract: This invention discloses organoleptically acceptable formulations containing S(+)-2-(p-isobutylphenyl)-propionic acid, also known as S(+) ibuprofen.

Abstract: The present invention concerns a particulate support matrix, a solid dosage form made therefrom, and processes for making such support matrices and dosage forms, which disintegrate or dissolve in a matter of just a few seconds once placed into the oral cavity.First, a porous particulate powder which will serve as the tablet support matrix is produced. In the second step, the pharmaceutical, for example an antihistamine, decongestant, or antibiotic is combined with the powder. Other additives may also be added to the mixture. In the third step the mixture is formed into a tablet. Finally, in the fourth step, a coating may be applied to the outer surface of the tablet to enhance the intactness and durability of the tablet.

Abstract: Antacid pharmaceutical compositions provide optimal buffering profiles of from 3.0 to 5.0 for immediate and long lasting relief from the symptoms of acid indigestion, sour stomach, heartburn and gas. The composition may comprise a dual or tripartite combination of the actives calcium carbonate, calcium or magnesium citrate and/or calcium phosphate which, as a result of their different activities, neutralize the excess stomach acid both immediately and continuously over time. The formulations also provide the individual with alternative dosage forms which may provide greater levels of calcium, less sodium and less production of gastrointestinal gas.

Abstract: The present invention relates to an acidic effervescent component for direct tableting of effervescent tablets and a process for its preparation.

Abstract: An effervescent granulated material for a pharmaceutical preparation contains calcium carbonate and citric acid. From 5-20 parts by weight of the total acid provided for the reaction with the calcium carbonate is replaced by at least one of malic acid, gluconic acid, lactic acid, and their salts. Citric acid and calcium carbonate are granulated with a partial reaction, and in each case at least part of the compound partially replacing the citric acid is granulated in solid, powdered form together with the citric acid and the calcium carbonate and/or dissolved in a granulation liquid or buffer solution.

Abstract: Pharmaceutical formulations of fluoxetine or an acid addition salt thereof, suitable for manufacturing dispersible tablets by direct compression and comprising, in addition to the active ingredient, the appropriate excipients and coadjuvants, selected from among disintegrants, diluents, lubricants, anti-adherents, sweeteners, flavorings and, optionally, colorants.Said formulations are suitable for manufacturing dispersible tablets which disintegrate in less than three minutes in water at 19.degree. C.-21.degree. C., and are appropriate for treatment of depression.

Abstract: A water soluble effervescent tablet formulation for preparing a disinfecting solution comprising a first tablet containing a bromide releasing agent and a second tablet containing a hypochlorite releasing agent.

Abstract: A composition for the cleaning and protection of partial dentures and the associated natural teeth of the wearer consisting essentially of a peroxy bleach cleanser in an amount of from about 5.0 wt % to about 70.0 wt % of the total weight of the composition; a fluoride source incorporated in a polymer matrix in a polymer/fluoride weight ratio of from about 3:1 to 1:3; at least one surfactant in an amount of from about 3.0 wt % to about 18.0 wt %; an organic peroxy acid bleach in an amount of from about 10.0 wt % to about 40.0 wt %; an active bicarbonate-based effervescent agent in an amount of from about 5.0 wt % to about 65.0 wt %. The composition is formulated as a two-layer compressed tablet wherein one layer contains the peroxyacid bleach cleanser and surfactant while the other layer contains the fluoride and a surfactant.

Abstract: The present invention is a process for forming a low density compression dosage unit to provide increased strength. The process of the present invention includes compacting under bi-level compaction pressure to provide a continuous-volume dosage unit which has a first volume defining an edge portion of the unit and a density which is greater than a density of a second volume defining a non-edge portion of the unit. The present invention also includes the product resulting from the process and apparatus used to make such units.

Abstract: An effervescent pharmaceutical composition for oral use in the treatment of a condition mediated through histamine H.sub.2 receptors contains a therapeutically effective amount of ranitidine or a physiologically acceptable salt thereof, about 25-70% by weight of disodium citrate, and about 20-50% by weight of sodium bicarbonate. Optionally, the effervescent composition may also Include about 0.5-25% by weight of an edible organic acid such as fumaric acid. Preferably, the effervescent composition is in the form of a tablet. Additional excipients for the effervescent composition include about 2-10% by weight of glycine, a flavoring agent, a sweetening agent, a binding agent, and/or a lubricant.

Abstract: Oral water-soluble pharmaceutical compositions containing a therapeutically effective amount of a water-soluble and stable estrogen compound such as estropipate (piperazine estrone sulfate), and at least one water-soluble, pharmaceutically acceptable calcium salt in the presence of a suitable, pharmaceutically acceptable excipient. Compositions which include an organic acid and a calcium carbonate or bicarbonate compound which reacts with the organic acid when the composition is added to water to provide effervescence are preferred.

Abstract: The invention relates to effervescent tablets and granules comprising a shell material, a basic sparkling component, an acidic sparkling component, and a sweetening agent, macro- and microelements and vitamins as active agents. The effervescent tablets and granules comprise 20-50% by mass of mannitol as shell material, 8-25% by mass of potassium hydrogen carbonate as basic sparkling component, 9-27% by mass of malic acid as acidic sparkling component, and 0.4-2.2% by mass of aspartame as sweetening agent. Furthermore, the invention relates to a process for preparing the above-described effervescent tablets and granules.

Abstract: Multilayered controlled-release solid pharmaceutical composition in tablet form suitable for oral administration comprising at least two layers containing active material in association with excipients and additives. One layer of the tablet releases a portion of the drug quickly while the other layer and optionally further layers release portions of the drug more gradually.

Abstract: A method of making a drug delivery system (10) includes the steps of filling a first water permeable capsule half with a drug and an osmotic agent and plugging an open-end (24) of the capsule (12). The method further includes the steps of disposing a water permeable film (30) over the capsule (12) and plug (28), filling a second capsule half (14) with a drug (18), and releasably mounting an open end (34) of the second capsule half (14) over the plugged end (24) of the first capsule half (12).

Abstract: A pharmaceutical formulation comprises a medicament and an effervescent couple, plus optionally other excipients. Preferred medicaments are antibiotics, together with a citric acid--sodium bicarbonate couple. The formulation is provided for make up with water into an antibiotic suspension.

Abstract: The invention relates to a thermal process for the production of directly tablettable granules and pharmaceutical preparations produced therefrom.

Abstract: The invention discloses a swallow tablet which is capable of disintegrating within less than about fifteen minutes and providing fast delivery of therapeutic drugs. The delivery system is composed of between 0.250 and 1.0 Gm of an alkali metal or alkaline-earth metal salt of an edible organic acid. A preferred delivery system is trisodium citrate.

Abstract: Disodium tiludronate tetrahydrate is provided for use in pharmaceutical compositions for oral administration in the form of a tablet, effervescent composition, capsule and the like.

Abstract: The present invention relates to administration forms having an extended gastric residence time, in the preparation of which mixtures of polymers containing lactam groups and polymers containing carboxyl groups are used, and which are distinguished both by marked swelling properties and by high dimensional stability in the swollen state.

Abstract: A pharmaceutical composition for oral use having analgesic activity containing a mixture of arginine and (S)-Ibuprofen in a molar ratio between 1.1 and 1.9 is described.

Abstract: Taste masked effervescent microcapsules are provided each microcapsule containing an effervescent admixture of sodium bicarbonate and citric acid microencapsulated with ethylcellulose, the effervescent microcapsules being useful in formulating taste masked effervescent chewable tablets also containing microencapsulated, unpleasant tasting drugs such as non-steroidal, anti-inflammatory, NSAID drugs.

Abstract: Described herein is a drug delivery system useful to deliver drugs at low dosage levels to patients in a sustained fashion and at a controlled rate. The system comprises a wettable polymeric matrix in which is dispersed a multiplicity of particles containing a substantially homogeneous blend of osmotically active excipient and not more than about 10% by weight of drug. The system is particularly well suited for delivery of therapeutic macromolecules such as protein drugs. Delivery of epidermal growth factor is exemplified.

Abstract: The present invention is a method of preparing rapidly dissolving comestible units such as tablets. The present invention also includes an apparatus for making the comestible units and the units themselves. The product prepared in accordance with the present invention can include active ingredients and is capable of dissolving in the mouth of the consumer within several seconds. The unit dosage forms prepared in accordance with the present invention are particularly useful as antacids and as a delivery vehicle for biologically active ingredients, especially those which are ideally combined with antacid ingredients in order to ameliorate the effects of antacid environment.

Abstract: The present invention relates to an aqueous pharmaceutical suspension composition comprising: from about 0.2% to 20% of a substantially water insoluble pharmaceutical active, e.g. ibuprofen; a suspension stabilizing effective amount of xanthan gum, pregelatinized starch and polyoxyethylene sorbitan monooleate; an effective amount of taste masking composition; and water, as well as a process for producing such aqueous pharmaceutical suspensions.

Abstract: A method is provided for making fast dissolving storage stable tablets by compression on standard high speed tablet production machinery wherein the formulation contains a carbohydrate having a special particle size and/or structure, in combination with controlled amounts of a transitory liquid as a lubricant, which liquid is removed following compression.

Abstract: The present invention relates to a solid dosage form including a new type of taste masking microparticle having an adsorbate of, for example, mannitol, in the core thereof.

Abstract: The effervescent mixture contains at least one acidic, insoluble or slightly soluble pharmaceutical active ingredient in the form of its soluble alkali metal salt or lysinate, which is present as an intimate mixture with the alkaline component and preferably coats the particles of the alkaline component of the effervescent system, for example sodium bicarbonate and/or sodium carbonate. Both components in very finely powdered form may also be present as granules, with the aid of a binder. In particular, the effervescent mixture contains, per 100 parts of active ingredient, at least 0.5 part, preferably 1 to 3 parts, of a surfactant, in particular dioctyl sulfosuccinate, and/or at least 1 part, preferably 3 to 5 parts, of a binder or suspending agent, in particular polyvinylpyrrolidone. The acidic component of the effervescent system is passivated on the surface.

Abstract: The pharmaceutical formulation in the form of an effervescent and/or disintegrating tablet or of instant granules contains at least one active ingredient having an irritating taste and at least one matrix which delays the release of the active ingredient and is present as an intimate mixture with the active ingredient particles or covers said particles and is applied to a carrier. The formulation releases at most 65%, preferably at most 50%, of the active ingredient in aqueous solution at room temperature within about 2 min but more than 70%, preferably at least 80%, of the active ingredient within max. 20 min, preferably max. 15 min, in 0.1N HCl at 38.degree. C. The matrix preferably contains at least one fatty ester and/or one wax, preferably having a melting point between 30.degree. and 45.degree. C., in particular between 32.degree. and 35.degree. C., and/or at least one cellulose derivative and/or at least one polymethacrylate.

Abstract: Denture cleanser tablet compositions are disclosed which include a flavoring agent in one layer and a bleaching agent in a second layer. This arrangement avoids deterioration of the tablet flavor and taste during storage.

Abstract: The present invention relates to a novel pharmaceutical composition for the preparation of effervescent powders or tablets incorporating ibuprofen or one of its pharmaceutically acceptable salts as the active ingredient. This composition comprises an effective amount of ibuprofen or one of its pharmaceutically acceptable salts; a pharmaceutically acceptable effervescent system comprising at least one alkali metal carbonate and at least one organic acid, preferably in a sufficient amount to give a pH below about 8; and at least one pharmaceutically acceptable antioxidant in a sufficient amount to stabilize the ibuprofen. This composition has a remarkable stability both in powder form and in tablet form.

Abstract: A composition and method of using the same which provides in as little as a single dose covering a 24 hour period a nutritional and/or dietary supplement which provides administration of water soluble and water insoluble active ingredients for immediate and sustained-release delivery.

Abstract: A solid effervescent antacid formulation comprising as primary ingredients from about 35 to about 53 percent by weight of calcium carbonate, from about 0 to about 14 percent by weight of magnesium carbonate, from about 3.5 to about 7 percent by weight of a bicarbonate salt, from about 3.5 to about 7 percent by weight of malic acid and from about 21 to about 35 percent by weight of a bulking agent.

Abstract: A water-soluble effervescent cleanser tablet comprising at least one proteolytic enzyme, a surfactant and an effervescing agent for use in ultrasonic cleaning equipment.