Gelatin Patents (Class 424/492)
  • Patent number: 10653790
    Abstract: The disclosure provides, among other things, compositions that bind to and inhibit the biological activity of soluble biomolecules, as well as pharmaceutical compositions thereof. The compositions may comprise a plurality of particles that specifically bind a target, such as a soluble biomolecule or a biomolecule on the surface of a pathogen, to inhibit the target (or pathogen) from interacting with other molecules or cells.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: May 19, 2020
    Assignee: NaNotics, LLC
    Inventors: John Dodgson, Louis Hawthorne
  • Patent number: 10201571
    Abstract: A nanoparticle composition for treating onychomycosis includes spherical-shaped nanoparticles having a particle size and a particle size distribution and coral-shaped nanoparticles having a particle size and a particle size distribution mixed within a penetrating solvent configured to deliver the nanoparticles to target area of a nail and/or surrounding tissue. The nanoparticle composition can be mixed with a carrier to provide or augment application of the nanoparticle composition to a target area. The penetrating solvent can deliver the nanoparticles to an infected area within the nail and/or at the bed of the nail so as to kill or deactivate the fungal microbes causing the onychomycosis.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: February 12, 2019
    Assignee: ATTOSTAT, INC.
    Inventor: William H. Niedermeyer
  • Patent number: 9408945
    Abstract: Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a first component comprising a dry preparation of a coagulation inducing agent, b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) mixing said first component and said second component under conditions effective to form a wet paste while essentially preventing degradation of the second component by said first component in a final container or transferring said wet paste into a final container, d) freezing and lyophilizing said paste in said container thereby obtaining a dry and stable hemostatic composition comprising said first and said second component in lyophilized form, and e) finishing said dry and stable hemostatic composition in said final container to a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: August 9, 2016
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Andreas Goessl, Atsushi Edward Osawa, Cary J. Reich
  • Patent number: 8987204
    Abstract: It is an object of the present invention to provide a bone regeneration agent and a bone supplementation formulation, in which a supplementation material itself is capable of promoting bone regeneration. The present invention provides a bone regeneration agent which comprises a gelatin having an amino acid sequence derived from a partial amino acid sequence of collagen.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: March 24, 2015
    Assignee: FUJIFILM Coporation
    Inventors: Takahiro Hiratsuka, Shouji Ooya, Ichiro Nishimura
  • Publication number: 20150064261
    Abstract: A multiparticulate dosage form includes a plurality of individual spheroidal enteric coated particulates having (a) a diameter of 0.1 to 2.5 mm; (b) a solid core containing an effective amount of a combination of an L-menthol source and a terpene-based essential oil; (c) a continuous proteinaceous subcoating over the core; and (d) an enteric coating over the subcoating. The multiparticulate dosage form can be used to treat gastrointestinal disorders.
    Type: Application
    Filed: November 7, 2014
    Publication date: March 5, 2015
    Inventors: Syed M. Shah, Fred Hassan, Daniel Hassan, Sarah Hassan
  • Publication number: 20150056291
    Abstract: Methods for forming and incorporating microparticles containing one or more active agents into adhesives are described. The methods involve spray drying a liquid of the one or more active agents and obtaining the active agent in a particulate form. The dry powder is then blended or otherwise incorporated with the adhesive of interest. Also described are various medical products utilizing the adhesive and one or more active agents in microparticle form, and related methods of use.
    Type: Application
    Filed: May 11, 2012
    Publication date: February 26, 2015
    Applicant: Avery Dennison Corporation
    Inventors: Anne Marie Wibaux, Peter Johnson
  • Publication number: 20150050352
    Abstract: A multiparticulate composition includes a plurality of individual enteric coated cores containing one or more terpene-based active ingredients and having a continuous proteinaceous subcoating layer covering the individual cores and separating the individual cores from their respective enteric coatings. The continuous proteinaceous subcoating layer prevents volatile terpene-based active ingredients from leaving the core, even when the core is heated during processing or stored for long periods above room temperature. The multiparticulate composition may be used to treat gastrointestinal disorders.
    Type: Application
    Filed: October 27, 2014
    Publication date: February 19, 2015
    Inventors: Syed M. Shah, Fred Hassan
  • Publication number: 20150044294
    Abstract: A multiparticulate composition includes a plurality of individual enteric coated cores containing one or more terpene-based active ingredients and having a continuous proteinaceous subcoating layer covering the individual cores and separating the individual cores from their respective enteric coatings. The continuous proteinaceous subcoating layer prevents volatile terpene-based active ingredients from leaving the core, even when the core is heated during processing or stored for long periods above room temperature. The multiparticulate composition may be used to treat gastrointestinal disorders.
    Type: Application
    Filed: October 27, 2014
    Publication date: February 12, 2015
    Inventors: Syed M. Shah, Fred Hassan
  • Patent number: 8940335
    Abstract: Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a dry granular preparation of a biocompatible polymer suitable for use in hemostasis, b) coating the granules in said dry granular preparation with a preparation of a coagulation inducing agent, thereby obtaining coagulation inducing agent coated polymer granules, c) filling said coagulation inducing agent coated polymer granules into a final container, d) finishing the final container to a storable pharmaceutical device containing said coagulation inducing agent coated polymer granules as a dry and stable hemostatic composition.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: January 27, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventor: Andreas Goessl
  • Publication number: 20140356440
    Abstract: A multiparticulate composition is formed from a plurality of individual cores including a hydrophobic phase containing peppermint oil dispersed in a microcrystalline cellulose-based gel and a hydrophilic phase containing a hydrogel. An enteric coating is over the individual cores. The multiparticulate composition can be used to treat gastrointestinal disorders.
    Type: Application
    Filed: August 18, 2014
    Publication date: December 4, 2014
    Applicant: Zx Pharma, LLC
    Inventors: Syed M. Shah, Daniel Hassan, Fred Hassan
  • Patent number: 8900630
    Abstract: Single-core and multi-core microcapsules are provided, having multiple shells, at least one of which is formed of a complex coacervate of two components of shell materials. The complex coacervate may be the same or different for each shell. Also provided are methods for making the microcapsules.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: December 2, 2014
    Assignee: DSM Nutritional Products
    Inventors: Nianxi Yan, Yulai Jin
  • Publication number: 20140348934
    Abstract: A rotary die system that includes first and second axially aligned, coacting rotary dies positioned adjacent one another. Each die includes a working surface having a plurality of recesses defined therein. The recesses in the first die are each configured to align with a recess in the second die to form a product cavity upon coaction of the first and second dies. The product cavity is configured to receive a product. Each recess in at least one of the first or second dies includes a pin therein that is configured to puncture a film that at least partially surrounds the product.
    Type: Application
    Filed: May 23, 2014
    Publication date: November 27, 2014
    Applicant: BARLEAN'S ORGANIC OILS, LLC
    Inventor: John Puckett
  • Patent number: 8895086
    Abstract: A multiparticulate composition includes a plurality of individual enteric coated cores containing one or more terpene-based active ingredients and having a continuous proteinaceous subcoating layer covering the individual cores and separating the individual cores from their respective enteric coatings. The continuous proteinaceous subcoating layer prevents volatile terpene-based active ingredients from leaving the core, even when the core is heated during processing or stored for long periods above room temperature. The multiparticulate composition may be used to treat gastrointestinal disorders.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: November 25, 2014
    Assignee: Zx Pharma, LLC
    Inventors: Syed Shah, Fred Hassan
  • Publication number: 20140314860
    Abstract: A multiparticulate composition includes a plurality of individual enteric coated cores containing one or more terpene-based active ingredients and having a continuous proteinaceous subcoating layer covering the individual cores and separating the individual cores from their respective enteric coatings. The continuous proteinaceous subcoating layer prevents volatile terpene-based active ingredients from leaving the core, even when the core is heated during processing or stored for long periods above room temperature. The multiparticulate composition may be used to treat gastrointestinal disorders.
    Type: Application
    Filed: September 23, 2013
    Publication date: October 23, 2014
    Applicant: ZX PHARMA LLC
    Inventors: SYED SHAH, FRED HASSAN
  • Patent number: 8858959
    Abstract: Safe and effective gel-bead vaccines for treating domesticated birds for diseases caused by cyst-forming protozoa, especially for coccidiosis.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: October 14, 2014
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Mark C. Jenkins, Raymond H. Fetterer, Joseph T. Persyn
  • Publication number: 20140255502
    Abstract: A pharmaceutical composition is provided. The pharmaceutical composition includes a nanoparticle, a shell and a drug, wherein the nanoparticle has an outer surface and the drug is mixed with the shell and is formed on the outer surface.
    Type: Application
    Filed: September 25, 2013
    Publication date: September 11, 2014
    Applicant: National Chiao Tung University
    Inventors: San-Yuan Chen, Wei-Ming Li
  • Patent number: 8821942
    Abstract: A calcium carbonate granulation and a method for preparing a calcium carbonate granulation are provided. The method includes applying an atomized binder to powdered calcium carbonate in a fluid bed granulator at a relatively high atomization pressure to achieve a reduced binder droplet size, and drying the resulting composition at elevated temperatures in a fluidized bed dryer. The resulting granulation include porous granules having a lower density and reduced mean particle size with improved compressibility. In addition, the resulting granulation can be compacted into tablets having a hardness 50% greater than the hardness of tablets formed from commercially available granulations.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: September 2, 2014
    Assignee: Access Business Group International LLC
    Inventors: David S. Chang, Huoy-Jiun Jean Wang
  • Patent number: 8820331
    Abstract: A smoking device includes a recipient or able to receive burning (i.e., burnable) products, preferably tobacco, and a filter element connected to the recipient, wherein the filter includes at least one breakable capsule, the capsule having a initial crush strength from 0.5 to 2.5 kp, and keeping a crush strength from 0.5 to 2.5 kp and a deformation of less than two third of its diameter prior to rupture after having been submitted to a smoking test. The invention is also relating to the capsule suitable for being incorporated in a smoking device, and to the process of manufacture of the capsule.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: September 2, 2014
    Assignee: V. Mane Fils
    Inventors: Didier Hartmann, Jean-Michel Hannetel, Nathalie Coursieres, Jean Mane
  • Patent number: 8790708
    Abstract: The present invention provides coated tablet formulations comprising neratinib maleate, and improved methods for making such coated tablets.
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: July 29, 2014
    Assignee: Wyeth LLC
    Inventors: Muhammad Ashraf, Mainuddin Mahmud, Chimanlall Goolcharran, Krishnendu Ghosh, Arwinder Singh Nagi
  • Publication number: 20140170224
    Abstract: A gelatin-based microgel was prepared by a simple method starting from gelatin and alginate. The microgel was composed of a soft gelatin-based core coated by a permeable membrane. Gelatin-based core was moderately crosslinked by a novel crosslinker 4-arm PEG succinimidyl glutarate (pentaerytheritol core) (sPEG-4A-GS(10 k)).
    Type: Application
    Filed: December 11, 2013
    Publication date: June 19, 2014
    Applicant: Agency for Science, Technology and Research
    Inventors: Jun Li, Zhongxing Zhang, Chengde Liu
  • Publication number: 20140105993
    Abstract: The present invention relates to novel microparticles formed of amphiphilic polyamino acids which transport active principle(s), AP(s), in particular protein and peptide active principle(s), and to novel modified-release pharmaceutical formulations comprising said AP microparticles. Microparticles of amphiphilic polyamino acid (PO) may include at least one AP (associated noncovalently) which spontaneously form a colloidal suspension of nanoparticles in water, at pH 7.0, under isotonic conditions. The microparticles may be obtained by atomization of a solution or colloidal suspension of PO comprising at least one AP, may have a size of between 0.5 and 100 microns, and may be dispersible in colloidal suspension.
    Type: Application
    Filed: November 21, 2013
    Publication date: April 17, 2014
    Applicant: Flamel Technologies, S.A.
    Inventors: Alain Constancis, You-Ping Chan
  • Patent number: 8691273
    Abstract: This invention relates generally to a preparation of bone repair compositions, and more special refers to a novel technology in preparing a matrix building polymer i.e. collagen with inclusions of hydroxyapatite particles as biomaterial for medical applications. In this composition that consists of hydroxyapatite particles embedded in a matrix at least 50% nm. Said composition is suitable as bone implant material, dental cement and for applications in wound healing.
    Type: Grant
    Filed: July 21, 2005
    Date of Patent: April 8, 2014
    Assignee: Lisopharm AG
    Inventors: Vsevolod Nikolaevich Rudin, Igor Vitallevich Melikhov, Vladimir Vasillevich Minaev, Andrei Yurievich Orlov, Viktor Evgenievich Bozhevolnov
  • Publication number: 20140093576
    Abstract: The present invention relates to a pharmaceutical composition in a solid unit dosage form for oral administration in a human or lower animal comprising: a. a safe and effective amount of a therapeutically active agent; b. an inner coating layer selected from the group consisting of poly(methacrylic acid, methyl methacrylate) 1:2, poly(methacrylic acid, methyl methacrylate) 1:1, and mixtures thereof; and c. an outer coating layer comprising an enteric polymer or film coating material; wherein the inner coating layer is not the same as the outer coating layer; wherein if the inner coating layer is poly(methacrylic acid, methyl methacrylate) 1:1 then the outer coating layer is not poly(methacrylic acid, methyl methacrylate) 1:2 or is not a mixture of poly(methacrylic acid, methyl methacrylate) 1:1 and poly(methacrylic acid, methyl methacrylate) 1:2; and wherein the inner coating layer and the outer coating layer do not contain any therapeutically active agent.
    Type: Application
    Filed: October 11, 2013
    Publication date: April 3, 2014
    Applicant: Warner Chilcott Company, LLC
    Inventors: Gregory Paul Dittmar, Joseph Michael Amante, Tony Ryan Cronk, Daniel Gary Newby
  • Publication number: 20140044793
    Abstract: A composition comprising a core material, having a taste value and a polymeric coating. The polymeric coating substantially surrounds the core material and comprises a cationic polymer and optionally an anionic polymer. The polymeric coating has a uniform thickness ranging from 2 ?m to 20 ?m. The composition provides release of a portion of the core material which is taste masked over a time period ranging from 0.5 minute to 2 minutes in the oral cavity and provides a modified-release of the remaining core material in a gastrointestinal tract.
    Type: Application
    Filed: September 20, 2011
    Publication date: February 13, 2014
    Applicant: SPI PHARMA, INC.
    Inventors: Diane Goll, Cecil W. Propst
  • Publication number: 20140030348
    Abstract: The invention relates to dosage forms that provide prolonged therapy. In particular, the invention relates to dosage forms including various pluralities of drug-containing resin particles. The invention also relates to methods of making these dosage forms and methods of treating using these dosage forms.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 30, 2014
    Applicant: NEOS THERAPEUTICS, LP
    Inventors: Mark Tengler, Russell McMahen
  • Publication number: 20140017325
    Abstract: A multiparticulate composition is formed from a plurality of individual cores including a hydrophobic phase containing peppermint oil dispersed in a microcrystalline cellulose-based gel and a hydrophilic phase containing a hydrogel. An enteric coating is over the individual cores. The multiparticulate composition can be used to treat gastrointestinal disorders.
    Type: Application
    Filed: September 23, 2013
    Publication date: January 16, 2014
    Applicant: ZX PHARMA, LLC
    Inventors: SYED SHAH, DANIEL HASSAN, FRED HASSAN
  • Publication number: 20140017324
    Abstract: An L-menthol-containing multiparticulate formulation includes a plurality of individual enteric coated cores containing L-menthol from an at least 80% pure L-menthol source. The enteric coated cores are effective to release at least about 35% of the L-menthol within about two hours, and at least about 80% of the L-menthol within about eight hours after being placed in an environment having a pH of 5 to 8. The L-menthol multiparticulate formulation can be used to treat gastrointestinal disorders.
    Type: Application
    Filed: September 23, 2013
    Publication date: January 16, 2014
    Applicant: ZX PHARMA, LLC
    Inventors: SYED SHAH, FRED HASSAN, DANIEL HASSAN, SARAH HASSAN
  • Patent number: 8617610
    Abstract: Disclosed are compositions including powdered green tea extract and a powdered preparation comprising polyunsaturated fatty acids. Also disclosed are methods of preparing the compositions and using the compositions in food products, as well as food products containing or that are prepared from the compositions.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: December 31, 2013
    Assignee: DSM Nutritional Products AG
    Inventors: Amber Lynn Gareau, Sharon Ann Spurvey Pittman, Lariza Beristain Taboada
  • Publication number: 20130330411
    Abstract: An oral cyclosporin composition comprises minicapsules having a core containing a cyclosporin, especially cyclosporin A in a solubilised liquid form. The minicapsules have a release profile to release the pre-solubilised cyclosporin, at least in the colon. The composition may be used for treating a range of intestinal diseases [FIG. 10].
    Type: Application
    Filed: July 15, 2013
    Publication date: December 12, 2013
    Inventor: Ivan Coulter
  • Publication number: 20130309313
    Abstract: Disclosed are compositions including powdered green tea extract and a powdered preparation comprising polyunsaturated fatty acids. Also disclosed are methods of preparing the compositions and using the compositions in food products, as well as food products containing or that are prepared from the compositions.
    Type: Application
    Filed: May 21, 2012
    Publication date: November 21, 2013
    Applicant: OCEAN NUTRITION CANADA LIMITED
    Inventors: Amber Lynn Gareau, Sharon Ann Spurvey Pittman, Lariza Beristain Taboada
  • Patent number: 8568784
    Abstract: Milled nanoparticles comprising a biologically active agent, at least one biopolymer and a coating containing at least one coating which is a polymer or ligand are produced using milling and coating techniques which have not previously been used for these applications.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: October 29, 2013
    Assignee: Morehouse School of Medicine
    Inventors: James W. Lillard, Rajesh Singh, Shailesh Singh
  • Publication number: 20130189366
    Abstract: Disclosed herein are systems for delivery of one or more molecules (such as a drug, for example, a small molecule, polypeptide, and/or nucleic acid) to a subject, for example to a targeted location in the subject. In some embodiments, the delivery system includes an encapsulated inducing agent or repressing agent and a plurality of cells. In some examples, the inducing agent or repressing agent and the cells are each separately encapsulated. In other examples, the encapsulated inducing agent or repressing agent and the cells are co-encapsulated. The cells include one or more genes which are operably linked to an inducible promoter or a repressible promoter which is inducible or repressible by the encapsulated inducing agent or repressing agent, respectively. Methods of use of the delivery systems, for example to treat or inhibit a disease or disorder in a subject, are also disclosed.
    Type: Application
    Filed: January 24, 2013
    Publication date: July 25, 2013
    Applicants: Brown University, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: The United States Government as Represented by the Department of Veterans Affairs, Brown University
  • Patent number: 8435953
    Abstract: An object of the present invention is to provide a sustained release composition containing SDF-1. The present invention provides a sustained release composition containing (1) SDF-1 and (2) a hydrogel containing modified gelatin having a carboxyl group and/or a sulfo group. Since the composition can release SDF-1, a chemokine which is a capable of promoting accumulation of vascular progenitor cells in vivo, in the sustained manner, it can be useful for treatment and/or suppression of symptom progression of ischemic disease or bone disease, as pharmaceutical preparations in various formulations.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: May 7, 2013
    Assignees: Ono Pharmaceutical Co., Ltd.
    Inventor: Yasuhiko Tabata
  • Publication number: 20130101673
    Abstract: The present invention is directed to implantable compositions comprising substantially spherical bioactive glass particles.
    Type: Application
    Filed: October 24, 2012
    Publication date: April 25, 2013
    Inventor: Mark D. Borden
  • Publication number: 20130084340
    Abstract: The present invention includes compositions and methods for the controlled release of active agents in a shelf-stable liquid formulation by blending one or more controlled release microbeads comprising one or more active agents, preparing a dense, thixotropic solution having a density that is at, or about, the density of the one or more microbeads comprising a thixotropic agent, water and one or more preservatives under conditions that reduce bubble formation and mixing the microbeads and the thixotropic solutions in a mixer that lacks scraping paddles.
    Type: Application
    Filed: November 26, 2012
    Publication date: April 4, 2013
    Applicant: NEOS THERAPEUTICS, LP
    Inventors: Mark Tengler, Paul Taskey, Daniel Lockhart, Russell McMahen
  • Patent number: 8409621
    Abstract: A method of forming particles, comprises accelerating a first stream comprising a first liquid, applying a charging voltage of at most 1.5 kV to the first stream, and vibrating the first stream, to form particles.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: April 2, 2013
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kyekyoon Kim, Hyungsoo Choi, Young Bin Choy
  • Publication number: 20130039990
    Abstract: The invention provides injectable, stem cell-containing calcium phosphate bone pastes for bone tissue engineering and methods of making and using the same.
    Type: Application
    Filed: April 29, 2011
    Publication date: February 14, 2013
    Applicant: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Huakun Xu, Michael Weir
  • Publication number: 20120315336
    Abstract: Described are injectable formulations of particulate olanzapine that produce a prolonged duration of action upon administration, and methods of making and using such formulations. The injectable formulations comprise particulate olanzapine.
    Type: Application
    Filed: May 3, 2012
    Publication date: December 13, 2012
    Applicant: Alkermes Pharma Ireland Limited
    Inventors: Stephen B. Ruddy, David Czekai, Gary Liversidge, Scott A. Jenkins, Elaine M. Liversidge
  • Patent number: 8298584
    Abstract: The present invention relates to a conformable and semi-permeable biopolymeric membrane suitable for tissue repair and protection. This membrane contains a first layer made from randomly oriented, reconstituted biopolymer fibers and, on top of the first layer, a coating layer made from biopolymer fibers.
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: October 30, 2012
    Assignee: Collagen Matrix, Inc.
    Inventors: Shu-Tung Li, Natsuyo Shishido Lee, Debbie Yuen
  • Publication number: 20120148677
    Abstract: Disclosed herein is a controlled release particle comprising a therapeutically effective amount of acid fibroblast growth factor (aFGF), entrapped by a particle composed by a biocompatible anionic biopolymer capable of binding to aFGF, and a cationic polymer. The method for manufacturing the controlled release particle and the method of using the particle for treating nervous injury are also provided.
    Type: Application
    Filed: March 23, 2011
    Publication date: June 14, 2012
    Applicant: Taipei Veterans General Hospital
    Inventors: Henrich Cheng, Son-Haur Hsu
  • Patent number: 8198364
    Abstract: There are provided poly(vinyl alcohol) polymers and copolymers containing vinyl alcohol or vinyl acetate and derivatives thereof such as poly(ethylene glycol)-grafted poly(vinyl alcohol) polymers or polyether-grafted poly(vinyl alcohol) polymers. These polymers can contain various functional groups. Such polymers can be use as polymer matrix or solid support for various chemical substrates such as organic substrates and reagents. Cross-linked poly(vinyl alcohol) polymers and copolymers are also provided. Methods for preparing such polymers as well as several of their uses are also included.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: June 12, 2012
    Assignee: Valorisation-Recherche, Limited Partnership
    Inventors: Julian Xiao-Xia Zhu, Pardin Christophe, Juntao Luo, William A. Lubell, Tarek Kassem
  • Publication number: 20120128780
    Abstract: Nanoparticulate bisphosphonate compositions, having an effective average particle size of less than 2000 nm, are described. The compositions are useful in treating bone resorption in a mammal.
    Type: Application
    Filed: October 17, 2011
    Publication date: May 24, 2012
    Inventors: Gary G. Liversidge, Scott Jenkins
  • Publication number: 20120076863
    Abstract: The present invention is directed to anti-hypertensive compositions comprising a nanoparticulate temocapril, or a salt or derivative thereof, having improved bioavailability. The nanoparticulate temocapril particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the treatment of hypertension and related diseases.
    Type: Application
    Filed: September 29, 2011
    Publication date: March 29, 2012
    Inventors: Scott Jenkins, Gary Liversidge
  • Publication number: 20120076864
    Abstract: Microcapsules for delivery of a liquid onto a surface such as a hard surface or a textile, such as mattress ticking, are disclosed. The microcapsules have a shell with an outer face and an inner face, the inner face encapsulating the liquid, and the liquid contains a microorganism such as a beneficial microorganism in a dormant state. The outer face of the microcapsules may comprise reactive functional groups whereby the outer face is chemically bondable, for instance covalently bondable to said surface. The microcapsules provide a beneficial microflora on said surface by rupture of the capsules deposited onto said surface to release the microorganism onto said surface. This may reduce or obviate the need for chemical antimicrobial agents to clean said surface. For surfaces which are fabrics or textiles, rupture and release may occur during use of the fabric or textile.
    Type: Application
    Filed: June 7, 2010
    Publication date: March 29, 2012
    Applicant: DEVAN CHEMICALS NV
    Inventors: Patrice Vandendaele, Robin Temmerman
  • Publication number: 20120040008
    Abstract: Pharmaceutical compositions of metabotropic glutamate 5 receptor (mGlu5) antagonists or a pharmacologically acceptable salt thereof are disclosed. The compositions contain the therapeutic active compound with non-ionic polymer and ionic polymer, binder and fillers in either matrix pellet, matrix tablet or coated pellets. The compositions provide a pH-independent in vitro release profile with NMT 70% in one hour, NMT 85% in 4 hour, and NLT 80% in 8 hours. The compositions are useful for the treatment of CNS disorders, such as Treatment-Resistant Depression (TRD) and Fragile X Syndrome.
    Type: Application
    Filed: August 4, 2011
    Publication date: February 16, 2012
    Inventors: Ashish Chatterji, Jingjun Huang, Stephanie Koennings, Kai Lindenstruth, Harpreet Sandhu, Navnit Shah
  • Publication number: 20120021058
    Abstract: Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a dry granular preparation of a biocompatible polymer suitable for use in hemostasis, b) coating the granules in said dry granular preparation with a preparation of a coagulation inducing agent, thereby obtaining coagulation inducing agent coated polymer granules, c) filling said coagulation inducing agent coated polymer granules into a final container, d) finishing the final container to a storable pharmaceutical device containing said coagulation inducing agent coated polymer granules as a dry and stable hemostatic composition.
    Type: Application
    Filed: June 1, 2011
    Publication date: January 26, 2012
    Applicants: Baxter Healthcare S.A., Baxter International Inc.
    Inventor: Andreas Goessl
  • Publication number: 20120015038
    Abstract: The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The formulations provide controlled release compositions that improve quality of life and reduced side-effects.
    Type: Application
    Filed: July 25, 2011
    Publication date: January 19, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ranjan Dohil, Jerry Schneider
  • Patent number: 8088403
    Abstract: The present invention relates to a method for preparing microcapsules by coacervation, and to the use of transglutaminase for cross-linking in complex coacervation. The present invention relates further to coacervation processes in general in which a material to be encapsulated is added to a solution comprising at least one colloid below the gelling temperature of the colloid. According to a method of the present invention, an emulsion or suspension of hydrophobic material is prepared after cooling a solution that includes hydrocolloids below the critical gelling temperature of a coacervate phase.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: January 3, 2012
    Assignee: Firmenich SA
    Inventors: Grégory Dardelle, Valéry Normand
  • Publication number: 20110256229
    Abstract: A pharmaceutical composition for the treatment of acute disorders is described. The composition comprises an essentially water-free, ordered mixture of at least one pharmaceutically active agent in the form of microparticles which are adhered to the surfaces of carrier particles which are substantially larger than the particles of the active agent or agents, and are essentially insoluble or sparingly soluble in water, in combination with a bioadhesion and/or mucoadhesion promoting agent adhered to the surfaces of said carrier particles. The composition is primarily intended for sublingual or intranasal administration. The invention also relates to a method for preparing the composition and to the use of the composition for the treatment of acute disorders.
    Type: Application
    Filed: June 30, 2011
    Publication date: October 20, 2011
    Applicant: OREXO AB
    Inventors: CHRISTER NYSTROM, SASANNE BREDENBERG
  • Patent number: 8034450
    Abstract: Described herein are microcapsules and emulsions prepared from low Bloom gelatin and methods of making and using thereof.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: October 11, 2011
    Assignee: Ocean Nutrition Canada Limited
    Inventors: Jonathan Michael Curtis, Wei Zhang, Yulai Jin, Colin James Barrow