Coated (e.g., Microcapsules) Patents (Class 424/490)
  • Patent number: 12165778
    Abstract: Methods for forming particulates that are highly consistent with regard to shape, size, and content are described. Particulates are suitable for use as reference materials. Methods can incorporate actinides and/or lanthanides, e.g., uranium, and can be used for forming certified reference materials for use in the nuclear industry. Methods include formation of an aerosol from an oxalate salt solution, in-line diagnostics, and collection of particles of the aerosol either in a liquid impinger or on a solid surface.
    Type: Grant
    Filed: December 13, 2022
    Date of Patent: December 10, 2024
    Assignee: Battelle Savannah River Alliance, LLC
    Inventors: Matthew S. Wellons, Michael A. Devore, II, Wendy W. Kuhne
  • Patent number: 12161736
    Abstract: A hydrophilic inorganic powder having excellent self-dispersibility in water or an aqueous solvent, which could not be conventionally achieved, and a cosmetic preparation containing the hydrophilic inorganic powder are provided by combining a hydrophilic surfactant and lipophilic surfactant. There is provided the hydrophilic inorganic powder comprising an inorganic powder as a base material; a hydrophobic-coat that covers the surface of the inorganic powder; and a hydrophilic-coat that covers the hydrophobic-coat, wherein ingredients of the hydrophilic-coat comprises both a hydrophilic surfactant and a lipophilic surfactant, and each of the hydrophilic surfactant and the lipophilic surfactant has a branched alkyl moiety in their molecules, wherein the hydrophilic inorganic powder has self-dispersibility in water or an aqueous solvent.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: December 10, 2024
    Assignee: MIYOSHI KASEI, INC.
    Inventor: Yukio Hasegawa
  • Patent number: 12163883
    Abstract: The present invention relates to sensors for detecting the presence or measuring the concentration of a target analyte, the sensor comprising: (i) a first phase comprising a first crosslinked polymer; (ii) a second phase comprising a second crosslinked polymer; and (ill) a target analyte recognition agent; the first phase and second phase arranged to form an optical grating. The first crosslinked polymer comprises low amounts of a crosslinking agent. The present invention also relates to methods of making a sensor for detecting the presence or measuring the concentration of a target analyte.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: December 10, 2024
    Assignee: Cambridge Enterprise Limited
    Inventors: Gita Khalili Moghaddam, Christopher Robin Lowe, Jeffrey Blyth
  • Patent number: 12156943
    Abstract: The invention relates to a tablet dosage form for buccal absorption of active ingredients comprising a population of particles and an active ingredient to be released in the oral cavity for absorption through the oral mucosa, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: December 3, 2024
    Assignee: Fertin Pharma A/S
    Inventor: Helle Wittorff
  • Patent number: 12156873
    Abstract: A composition for use in the treatment of ocular hyperemia includes an anti-angiogenic agent and an ? adrenergic receptor agonist. A method for treating ocular hyperemia for a patient includes inhibiting a plurality of kinase receptors of the patient with an MKI; and activating ? adrenergic receptor of the patient with an agonist of the receptor.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: December 3, 2024
    Assignee: ADS Therapeutics LLC
    Inventors: Scott Whitcup, Rong Yang, Jinsong Ni
  • Patent number: 12144896
    Abstract: The treatment of cancer using platinum-based compounds includes certain drawbacks such as biocompatibility, loading efficacy, leakage of drugs during storage and in the bloodstream, more particularly due to the nature of the nanocarriers for platinum delivery. A nanosystem that allows improving platinum-based drug in vivo performance, kinetics and efficacy. In particular, nanoparticles useful as drug delivery system, these nanoparticles being formed from at least: (a) platinum-based drug, (b) poly-L-arginine, and (c) hyaluronic acid. Particularly, these nanoparticles have been tested in terms of entrapment efficiency and also carried out in vitro experiments in 2D cell culture (viability studies on B6KPC3, A549 and HT-29 cells) and 3D cell model (spheroids made of HTC-116) and in vivo experiments (by injecting intravenously to mice the nanoparticles or comparative oxaliplatin solution) to prove their efficiency.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: November 19, 2024
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—, UNIVERSITE D'ANGERS, CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERS
    Inventors: Giovanna Lollo, Jean-Pierre Benoit, Marie Brachet-Botineau
  • Patent number: 12144897
    Abstract: A method of treatment or prevention of HIV and other viral infection comprising the administration of a biopolymer-based hydrogel nanoparticles and/or microparticles. In preferred embodiments, the particles comprise chitosan, hydroxyethyl cellulose (HEC), and linseed oil polyol. These biopolymer-based hydrogel nanoparticles and/or microparticles are antiviral agents that can be employed alone or in combination with other drugs for treatment of the viral infection. Further, the pre-treatment with the particles is highly effective at inhibiting viruses. Therefore, this antiviral biopolymer-based hydrogel nanoparticles and/or microparticles may also be employed as a prophylactic.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: November 19, 2024
    Assignee: The Florida International University Board of Trustees
    Inventors: Madhavan Nair, Andrea Raymond, Arti Vashist
  • Patent number: 12138362
    Abstract: Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.
    Type: Grant
    Filed: November 15, 2023
    Date of Patent: November 12, 2024
    Assignee: MicroVention, Inc.
    Inventors: Gregory M. Cruise, Steve Plotkin, Xinping Wu
  • Patent number: 12134779
    Abstract: The present disclosure provides feeder hydrogel particles that can function to support the growth, proliferation, and/or activation of a target cell in culture. The present disclosure also provides methods of culturing target cells with feeder hydrogel particles.
    Type: Grant
    Filed: November 1, 2023
    Date of Patent: November 5, 2024
    Assignee: Slingshot Biosciences, Inc.
    Inventors: Anh Tuan Nguyen, Jeffrey Kim, Keunho Ahn, Daixuan Zhang
  • Patent number: 12121612
    Abstract: A porous silica material for use as a pharmaceutical or dietary active ingredient having pores in the mesoscale range (2-50 nm), wherein the average pore size of the pores in the mesoscale range is in the range of 2 to 25 nm, and the pore size distribution (PSD) in the mesoscale range is such that at least 80% of the pores fall within the range of 2 to 25 nm.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: October 22, 2024
    Assignee: Sigrid Therapeutics AB
    Inventors: Robert Csikasz, Tore Bengtsson, Natalia Kupferschmidt, Alfonso E. Garcia-Bennett
  • Patent number: 12090233
    Abstract: Masking particles which comprise a drug-containing particle containing a drug, an acid, and a carbonate, the drug-containing particle being coated with a coating layer containing a water-insoluble polymer sufficiently suppress drug release in the oral cavity and pharynx, rapidly release a drug after swallowing, and easily control the release suppression time of a drug. The acid may be at least one organic acid. The carbonate may be at least one water-soluble carbonate. Oral pharmaceutical compositions include tablets, granules, fine granules, powders.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: September 17, 2024
    Assignee: TOWA PHARMACEUTICAL CO., LTD.
    Inventors: Tatsuya Honjo, Megumi Murahashi, Masaki Sato, Kayo Yuminoki, Isamu Saeki, Yutaka Okuda
  • Patent number: 12083229
    Abstract: There is provided an ocular drug delivery formulation comprising a delivery carrier comprising a cellulosic polymer and an anionic polysaccharide and nanoparticles comprising an amphiphilic non-ionizable block copolymer and a cannabinoid. The formulation has a gel point of about 30° C. to about 37° C.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: September 10, 2024
    Assignee: INMED PHARMACEUTICALS INC.
    Inventors: Sazzad Hossain, Maryam Kabiri, Vikramaditya Ganapati Yadav
  • Patent number: 12077728
    Abstract: Laundry care additive particles and a dryer sheet that include a water soluble carrier and capsules characterized by substantially inorganic shells, for example silica-based shells. The present disclosure further relates to methods of making and using such compositions.
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: September 3, 2024
    Assignee: The Procter & Gamble Company
    Inventors: Andre Martim Barros, Mariana B. T. Cardoso, Johan Smets, Steven Daryl Smith, Pierre Daniel Verstraete, Valerie Wong
  • Patent number: 12064522
    Abstract: A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more silicon oxide materials is provided. The method entails alternating exposing the particles to gaseous or vaporous SiCl4 and gaseous or vaporous H2O at a reduced temperature and in the absence of a catalyst.
    Type: Grant
    Filed: October 1, 2021
    Date of Patent: August 20, 2024
    Assignee: Applied Materials, Inc.
    Inventors: Fei Wang, Miaojun Wang, Colin C. Neikirk, Jonathan Frankel, Pravin K. Narwankar
  • Patent number: 12060368
    Abstract: The present invention relates to a novel selenophenochromene hydroxamic acids as angiogenesis inhibitors, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment or prevention of various diseases and disorders by administration of such substances.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: August 13, 2024
    Assignee: Latvian Institute of Organic Synthesis
    Inventors: Pavels Arsenjans, Jelena Vasiljeva, Ilona Domraceva
  • Patent number: 12052988
    Abstract: Provided is an antibacterial liquid with excellent temporal stability in which caking due to sedimentation of solid components does not occur and with which a film capable of stably maintaining antibacterial properties can be formed, in a case of being formed into a film. Also provided are an antibacterial film formed using the antibacterial liquid, and a spray and a cloth including the antibacterial liquid. The antibacterial liquid includes an antibacterial microparticle, a binder, and a solvent, in which the antibacterial microparticle contains a silver-supporting inorganic oxide, the binder includes at least one compound having a siloxane bond, the solvent includes an alcohol and water, the concentration of solid contents is less than 5% by mass with respect to the total mass of the antibacterial liquid, and the content of the compound having a siloxane bond is 60% by mass or more with respect to the total solid content of the antibacterial liquid.
    Type: Grant
    Filed: September 2, 2022
    Date of Patent: August 6, 2024
    Assignee: FUJIFILM Corporation
    Inventors: Naotoshi Sato, Mitsumasa Hamano
  • Patent number: 12042559
    Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.
    Type: Grant
    Filed: August 8, 2023
    Date of Patent: July 23, 2024
    Inventors: Kanji Meghpara, Jaydeep Vagashiya, Navnit H. Shah, Dipen Desai, Wantanee Phuapradit, Harpreet Kaur Sandhu, Siva Ram Kiran Vaka, Namdev B. Shelke, Ashish Chatterji
  • Patent number: 12029767
    Abstract: The present disclosure relates to a method for treating or preventing a viral and/or bacterial respiratory infection in a subject, the method comprising administering to the respiratory tract of the subject an effective amount of one or more bacteria from family Pasteurellaceae.
    Type: Grant
    Filed: June 2, 2021
    Date of Patent: July 9, 2024
    Assignee: Telethon Kids Institute
    Inventors: Caitlyn Granland, Lea-Ann Kirkham, Peter Richmond
  • Patent number: 12029709
    Abstract: The present disclosure relates to an inhalable formulation, suitable for use in a dry powder inhaler, for the delivery of epinephrine, or a pharmaceutically acceptable salt or derivative thereof. The inhalable formulation further comprises a solid carrier and results in a stable formulation with useful physical properties for delivery to the lungs of a subject in need of epinephrine.
    Type: Grant
    Filed: August 11, 2022
    Date of Patent: July 9, 2024
    Assignee: De Motu Cordis Pty Ltd
    Inventors: John Fraser, Sean Mark Dalziel, Teresa Iley, Jonathan Brazier, Patrick Joseph Lynch, John Fredatovich, Benjamin Barnaby Trout
  • Patent number: 12027245
    Abstract: The present disclosure provides a pharmaceutical composition for multi-stage release of psychoactive substances including cannabinoids. The pharmaceutical composition comprises two or more staged compositions having different release profiles or different release time such that the one or more active agents in each of the two or more staged compositions are released into the subject's blood stream at different time points.
    Type: Grant
    Filed: December 8, 2022
    Date of Patent: July 2, 2024
    Assignee: Green Sky Creations LLC
    Inventors: Simon Robinson, Brad Douglass
  • Patent number: 12016850
    Abstract: The disclosure is directed to pharmaceutical compositions for oral administration comprising deferiprone. In particular, the disclosure is also directed to modified release tablets suitable either for twice daily administration or once daily administration. The disclosure is also directed to methods of making and using the same.
    Type: Grant
    Filed: April 11, 2022
    Date of Patent: June 25, 2024
    Assignees: Chiesi Farmaceutici S.p.A., Università degli Studi di Milano
    Inventors: Marisa Pertile, Andrea Gazzaniga, Matteo Cerea, Micol Cirilli
  • Patent number: 12016840
    Abstract: The present invention relates to a controlled release formulation comprising the active compounds tesofensine and a beta blocker, such as metoprolol or carvedilol, or a pharmaceutically acceptable salt thereof. The invention further relates to use of the controlled release formulation in a method of treatment of diabetes, obesity, or an obesity associated disorder.
    Type: Grant
    Filed: August 24, 2022
    Date of Patent: June 25, 2024
    Assignee: Saniona A/S
    Inventors: Peter G. Nielsen, Mikael S. Thomsen, Bent Højgaard
  • Patent number: 12016833
    Abstract: Exemplary embodiments of the present invention relate to a combination formulation for treatment or enhancing the therapy of liver disease, and more particularly, to a combination formulation prepared by containing colchicine and metformin as main active ingredients. The composition according to exemplary embodiments of the present invention may be used as an effective therapeutic agent for liver disease capable of treating and preventing liver fibrosis, liver cirrhosis, liver cancer, or hepatitis by reducing the amount of fat accumulated in the liver tissues by a synergistic effect of colchicine and metformin and lowering glucose tolerance and insulin tolerance and further, may be used as an excellent drug capable of replacing ursodeoxycholic acid.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: June 25, 2024
    Inventors: Ju Ho Yoon, Wang Jo Cha, Sun Ah Ham
  • Patent number: 12011509
    Abstract: The present invention relates to development of a novel cannabinoid-based gold nanoparticle drug delivery system for intravenous or localized administration of cannabinoid drugs. More specifically, the gold nanoparticles with a specific size range are conjugated with various cannabinoid molecules (CBD and THC molecules) to synthesize a stable and biocompatible nano-delivery system suitable for both localized and intravenous administration.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: June 18, 2024
    Inventors: Anshuman Jakhmola, Jahangir Tavakkoli, Kevin Rod
  • Patent number: 11998638
    Abstract: The invention relates to a process for preparing PCL-comprising microparticles, to microparticles obtainable by said process, to gel hence obtained and to several uses of the gel such as for the preparation of a medicament for treating a skin abnormality or disfigurement, and/or for controlling bladder function and/or controlling gastric reflux and/or for treating erectile dysfunction and/or for treating vocal cords. The gel may also be used for cosmetic applications.
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: June 4, 2024
    Assignee: AQTIS I.P B.V.
    Inventors: Henderikus Super, Paul Willem Mijnen, Pieter Gerard Zijlstra, Dirk Wybe Grijpma
  • Patent number: 11999829
    Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.
    Type: Grant
    Filed: March 20, 2023
    Date of Patent: June 4, 2024
    Assignee: ETH ZURICH
    Inventors: Jean-Christophe Leroux, Simon Matoori, Olha Voznyuk Wuerthinger
  • Patent number: 11969449
    Abstract: This invention relates to a composition for use in the treatment of major depressive disorder. In addition, this invention relates to a composition for use in the treatment and/or improvement of mood disturbances and for use in the treatment and/or improvement of the mood state.
    Type: Grant
    Filed: March 1, 2022
    Date of Patent: April 30, 2024
    Assignee: PROBIOTICAL S.P.A.
    Inventor: Giovanni Mogna
  • Patent number: 11957764
    Abstract: The disclosure relates to a protein-type nanoparticle for multi-specific antibody delivery, a preparation method, and its application. The protein-type nanoparticle includes a polyester and a protein with a hydrophobic domain, and the hydrophobic domain of the protein is bound with the polyester through hydrophobic interactions. The protein is at least one of albumin, globulin and cell wall protein. The protein-type nanoparticle of the present disclosure has excellent stability and biocompatibility. The protein-type nanoparticle is used to prepare a multi-specific antibody delivery platform (?Fc-NP) by binding anti-IgG-Fc antibody or anti-IgG-Fc antibody fragment, which can stably, quickly and easily bind to multiple specific antibodies through antigen-antibody interaction and enhance the therapeutic effect of specific antibodies.
    Type: Grant
    Filed: January 27, 2023
    Date of Patent: April 16, 2024
    Assignee: SOUTH CHINA UNIVERSITY OF TECHNOLOGY
    Inventors: Jun Wang, Zhiting Cao, Song Shen, Qianni Ye, Xiaojiao Du, Xianzhu Yang, Youyong Yuan
  • Patent number: 11957046
    Abstract: An electroluminescent device includes a first electrode and a second electrode facing each other; an emission layer disposed between the first electrode and the second electrode and including a plurality of quantum dots and a first hole transporting material having a substituted or unsubstituted C4 to C20 alkyl group attached to a backbone structure; a hole transport layer disposed between the emission layer and the first electrode and including a second hole transporting material; and an electron transport layer disposed between the emission layer and the second electrode.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: April 9, 2024
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Moon Gyu Han, Dae Young Chung, Kwanghee Kim, Eun Joo Jang, Chan Su Kim, Kun Su Park, Won Sik Yoon
  • Patent number: 11926467
    Abstract: A non-aspirating dispenser containing a gel therein for delivery to a desired surface such as a medical article. More specifically, a gel that is dispensed in the form of droplets that are free of air or a gas therein and with reduced drift potential. The dispenser has a container having a flexible bag therein enclosing a thixotropic gel, and has a pressurized gas that is capable of exerting pressure on the bag and forcing the gel out of said bag in a steady stream upon pressing an actuator that is operatively connected to an ejection valve. The bag is free of propellants, and does not produce an aerosol. The gel is thixotropic and is utilized for keeping medical instruments moist in order to prevent soils present thereon from drying out, which can make reprocessing of medical instruments more difficult and less effective. The dispenser implemented at a point of use for transport or prior to delayed reprocessing in the reprocessing area.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: March 12, 2024
    Assignee: AMERICAN STERILIZER COMPANY
    Inventors: Nancy-Hope E. Kaiser, Daniel Rochette, Bradley A. Baan
  • Patent number: 11925693
    Abstract: Polymeric nanoparticles comprising a defined set of biologically active agents that provide for targeted stimulation of non-responsive T cells, e.g. T cells involved in cancer, are provided.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: March 12, 2024
    Inventors: Qian Yin, Yu Wong, Mark M. Davis
  • Patent number: 11918011
    Abstract: Described are compositions and methods relate to stable, high-payload, non-porous enzyme-containing coated granules with improved resistance to activity loss during steam pelleting.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: March 5, 2024
    Assignee: DANISCO US INC.
    Inventors: Samuel A. Maurer, Nathaniel T. Becker, Douglas A. Dale, Peyman Moslemy, Michael Reichman, Alan Martin Allgeier
  • Patent number: 11918711
    Abstract: An aerogel carrying an active material, and a composite of a hydrogel and the aerogel are provided. The method for preparing the composite according to the present invention comprises the steps of preparing a plurality of aerogel particles having an active material in the pores, preparing a polymer solution in which a polymer is dissolved in a water-soluble solvent, preparing an aerogel/polymer dispersion by homogenizing after mixing the aerogel particles in the polymer solution, and preparing an aerogel/hydrogel composite carrier by mixing the dispersion with a crosslinking agent solution. According to the present invention, by producing a hydrogel composite in which a plurality of aerogel particles is distributed, a complex carrier in which oil and moisture can be carried simultaneously without any surfactant can be provided. Furthermore, a composite carrier having improved properties such as low density, high strength, high component content and stable desorption can be prepared.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: March 5, 2024
    Assignee: Industry-University Cooperation Foundation Hanyang University
    Inventor: Tae Won Kim
  • Patent number: 11911518
    Abstract: Therapeutic compositions deliver a therapeutic amount of methylphenidate in a delayed and extended release formulation. The dosage form exhibits a lag time prior to release of from 6 to 8 hours or longer, followed by a sustained release period.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: February 27, 2024
    Assignee: Ironshore Pharmaceuticals & Development, Inc.
    Inventors: David Lickrish, Feng Zhang
  • Patent number: 11912961
    Abstract: Liquid fabric care compositions that include certain fabric treatment adjuncts and/or water, where the compositions further include capsules characterized by substantially inorganic shells, for example silica-based shells. The present disclosure further relates to methods of making and using such compositions.
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: February 27, 2024
    Assignee: The Procter & Gamble Company
    Inventors: Andre Martim Barros, Mariana B. T. Cardoso, Johan Smets, Steven Daryl Smith, Pierre Daniel Verstraete, Valerie Wong
  • Patent number: 11905301
    Abstract: The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.
    Type: Grant
    Filed: August 4, 2021
    Date of Patent: February 20, 2024
    Assignee: Clarity Pharmaceuticals Ltd.
    Inventors: Paul Stephen Donnelly, Michelle Therese Ma, Denis Bernard Scanlon
  • Patent number: 11896718
    Abstract: The present invention relates to a composite preparation in a core tablet form, composed of an inner core containing rabeprazole as an effective ingredient; an outer layer portion including the bilayer structure of a sustained release layer and an immediate release layer and containing mosapride as an effective ingredient. The core tablet composite preparation according to the present invention is characterized by exerting sufficient pharmacological activity of rabeprazole and mosapride even upon administration of one tablet once a day.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: February 13, 2024
    Inventors: Byung Jin Kim, Hee Yong Song, Youn Woong Choi, Seong Yeob Kim
  • Patent number: 11898055
    Abstract: The invention relates to polyelectrolyte multilayer coatings and, methods for their preparation and application to substrates to enhance the bioactivity and corrosion protection of the substrates' surface. The invention is particularly suitable for coating substrates employed for medical applications, such as but not limited to medical implant devices for drug and/or biologics delivery in a patient. The substrate has a positive or negative charge. The polyelectrolyte multilayer coatings include at least a first polymer layer and a second polymer layer. The first polymer and second polymer have opposite charges. Each of the polymer layers is individually applied using a layer-by-layer such that an alternating charge multilayer coating is formed.
    Type: Grant
    Filed: October 6, 2021
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Prashant N. Kumta, Sangeetha Kunjukunju, Nicole J. Ostrowski, Abhijit Roy, Boeun Lee, Madhumati Ramanathan
  • Patent number: 11884663
    Abstract: Crystalline forms of emetine dihydrochloride (Compound I dihydrochloride) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms of Compound I dihydrochloride.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: January 30, 2024
    Assignee: Acer Therapeutics, Inc.
    Inventor: John Klopp
  • Patent number: 11884738
    Abstract: The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different protein receptor on a T cell surface.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: January 30, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Andrew Wang, Yu Mi
  • Patent number: 11865080
    Abstract: RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.
    Type: Grant
    Filed: December 13, 2022
    Date of Patent: January 9, 2024
    Assignee: GlaxoSmithKline Biologicals SA
    Inventors: Andrew Geall, Katrin Ramsauer, Gillis Otten, Christian Walter Mandl
  • Patent number: 11865208
    Abstract: Topical vaginal compositions are disclosed herein which include silica microspheres and an active ingredient in the amount of 0.001 to 15.0% w/w selected from estradiol, metronidazole, clindamycin, butoconazole, and combinations thereof. The topical compositions provide sustained release of the active ingredient so as to reduce skin irritation.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: January 9, 2024
    Assignee: Sol-Gel Technologies Ltd.
    Inventors: Marina Shevachman, Amira Ze' Evi, Eilon Asculai, Batella Benyaminovich, Nir Avram, Chaim Aschkenasy
  • Patent number: 11857694
    Abstract: Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.
    Type: Grant
    Filed: February 23, 2022
    Date of Patent: January 2, 2024
    Assignee: MicroVention, Inc.
    Inventors: Gregory M. Cruise, Steve Plotkin, Xinping Wu
  • Patent number: 11857604
    Abstract: The present invention relates to the field of nanovectors for the delivery of active substances in the body, in particular for the treatment of tumours. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in the tumour tissues.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: January 2, 2024
    Assignee: NH THERAGUIX
    Inventors: Olivier Tillement, François Lux, Fabien Rossetti, Vu-Long Tran, Clélia Mathieu, Myleva Dahan
  • Patent number: 11849733
    Abstract: A baked food composition is provided that exhibits an unexpectedly loose, crunchy texture and multi-textural chew. The baked composition comprises a high amount of expanded inclusions and shredded root vegetable, which are agglomerated by a binder component comprising low amounts of oil, added sugar, and flour. The food composition is preferably free of hydrocoiloid gums and sugar syrups.
    Type: Grant
    Filed: September 24, 2021
    Date of Patent: December 26, 2023
    Assignee: Mondelez Europe GmbH
    Inventors: Karine Coue Briant, Omar Crewe, Fidelma Crowe, Frederik Jensen, Sharat Jonnalagadda, Abby S. Kendall, Joseph Lavin, Adam Melonas, Janelle Myers, Tom Nosek, Lena Marisa Sawin, JulLea Stolsky, Vani Vemulapalli
  • Patent number: 11851707
    Abstract: A method of predicting the development of chronic lung allograft dysfunction (CLAD) in lung transplant patients using N-myc-interactor (NMI) as a biomarker and associated treatment thereof is presented. Also presented is a method of reducing the risk of CLAD by administering a therapeutic agent capable of increasing NMI in the patient. NMI is a critical regulator of epithelial-to-mesenchymal transition (EMT) and an important precursor to development of CLAD. NMI expression is reduced in CLAD patients and can be used as an early diagnostic biomarker to predict the development of CLAD. NMI can also be used as a drug target for a therapeutic to increase expression of NMI and treat chronic lung disease such as CLAD. Therapeutics comprising NMI protein or NMI gene can be used as potential treatments for chronic lung diseases such as CLAD.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: December 26, 2023
    Assignee: University of South Florida
    Inventors: Nirmal S. Sharma, Mudassir Banday, Andreas Seyfang
  • Patent number: 11849756
    Abstract: A capsule for use in a smoking article includes a liquid sensory enhancing material; and a shell surrounding the liquid sensory enhancing material. The shell has an outer surface rendered hydrophobic by hydrophobic groups covalently bond to the outer surface of the shell. The shell may be rendered hydrophobic by reacting hydroxyl groups at outer surface of the shell with fatty acid halides to covalently attach fatty acid moieties to the surface of the capsule.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: December 26, 2023
    Assignee: Philip Morris Products S.A.
    Inventors: Aurélien Guyard, Laurent Lavanant, Yves Jordil
  • Patent number: 11844789
    Abstract: Compositions and methods for the treatment and control of various conditions in an animal which comprises administering to said animal an effective amount of an immediate release composition of about 0.5% to 50% wt/wt of active ingredient together with excipients to a total of about 100%, wherein said composition dissolves in a relatively short period of time, e.g., 75 seconds or less, 5 seconds or less, or 3 seconds or less, upon administration to said animal.
    Type: Grant
    Filed: November 4, 2021
    Date of Patent: December 19, 2023
    Assignee: NewMarket Pharmaceuticals LLC
    Inventors: David Rock, Mark Ridall
  • Patent number: 11844806
    Abstract: The present invention relates to a novel two-component system comprising acetylsalicylic acid (ASA) and which is particularly useful in providing an aqueous solution of ASA for immediate peroral administration.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: December 19, 2023
    Assignee: Asamedic AS
    Inventor: Carl Henrik Gorbitz
  • Patent number: 11839681
    Abstract: The present invention includes: 1) dissolving a first binder in a first solvent; 2) dissolving a dispersing agent in a solution in which the first binder is dissolved; 3) adding charcoal powder to the solution obtained in 2) and performing homogenous mixing to produce a dispersion in which the charcoal powder is bound to the first binder; 4) spray drying the dispersion obtained in 3) to produce a primary capsule from which the first solvent is removed; 5) dissolving a second binder and a softening agent in a second solvent; 6) homogeneously mixing a coloring agent and the dispersing agent with a solution in which the second binder and the softening agent are dissolved; 7) mixing the primary capsule with the solution obtained in 6) to produce a double capsule dispersion in which the primary capsule is bound to the second binder; and 8) spray-drying the double capsule dispersion to product a double capsule from which the second solvent is removed.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: December 12, 2023
    Assignee: BIOGENICS, INC.
    Inventors: Chan-Jae Shin, Tae-Sung Ko, Hyun-Gyu Shin, Jeong-Ho Park