Coated (e.g., Microcapsules) Patents (Class 424/490)
  • Patent number: 11026879
    Abstract: The invention deals with a dispersion of drops of a first phase in a second phase substantially immiscible with the first phase, the solubility of the first phase in the second phase being less than 5% by mass. Each drop includes a core formed with a first phase and a shell formed with a coacervate layer interposed between the first phase and the second phase. The coacervate layer comprises a first precursor polymer of the coacervate and a second precursor polymer of the coacervate, one of the first phase and of the second phase is aqueous, and the other of the first phase and of the second phase is oily.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: June 8, 2021
    Assignee: CAPSUM
    Inventors: Mathieu Goutayer, Jerome Bibette
  • Patent number: 11026892
    Abstract: Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions using solventless mixing methods. Excess coating material that is not bound to a coated API particle may be removed by a sieving process. Coating and dosing ratios can also be optimized to minimize the amount of excess unbound coating material. Specifically, a coating ratio and/or a dosing ratio can be used to minimize the residual amount of excess unbound coating material to minimize agglomeration of coating material during storage. In some embodiments, a pharmaceutical composition is provided, the pharmaceutical composition comprising: 65-85% w/w API particles; 15-30% w/w coating material coating the API particles; and 3-15% w/w matrix surrounding the coated API particles, wherein the pharmaceutical composition comprises a disintegration time rate of less than 10 seconds for at least six months under storage conditions of at least 25° C. and at least 60% relative humidity.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: June 8, 2021
    Assignee: Catalent U.K. Swindon Zydis Limited
    Inventors: Rosaleen McLaughlin, Simon Andrew Martyn Howes, Craig Wheadon, Jonathon Whitehouse
  • Patent number: 11013693
    Abstract: The present invention relates to a process for the preparation of an oral pharmaceutical preparation in the form of enteric coated granulate comprising dimethyl fumarate and pharmaceutically acceptable excipients. The invention relates also to an oral pharmaceutical preparation in the form of enteric coated granulate obtained by the process of the present invention and to use of the preparation in the treatment of multiple sclerosis.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: May 25, 2021
    Inventors: Przemyslaw Skoczen, Aleksandra Drozd, Marek Cichocki
  • Patent number: 11013908
    Abstract: A nanodevice includes an array of metal nanorods formed on a substrate. An electropolymerized electrical conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open or close responsively to electrical signals applied to the nanorods. A cell loading region is disposed in proximity of the reservoir, and the cell loading region is configured to receive stem cells. A neurotrophic dispensing material is loaded in the reservoir to be dispersed in accordance with open pores to affect growth of the stem cells when in vivo.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: May 25, 2021
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Steven J. Holmes, Qinghuang Lin, Emily R. Kinser, Nathan P. Marchack, Roy R. Yu
  • Patent number: 10996496
    Abstract: In present invention, various embodiments provide a photothermotropic composite film. The composite film comprises a matrix and one or more nanostructures comprising a metal oxide semiconductor which is configured to convert radiant energy to thermal energy. The matrix has a property which is changeable based on the thermal energy received by the matrix from the metal oxide semiconductor. In a preferred embodiment, hybridization of the poly(N-isopropylacrylamide) (PNIPAM) hydrogel and antimony-tin oxide (ATO) is provided as the composite film. In this film, the ATO absorbs at near-infrared (NIR) region and acts as nanoheater to induce the optical switching of the hydrogel. The behaviour of this composite film can be used as a new generation of autonomous passive smart windows for climate-adaptable solar modulation.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: May 4, 2021
    Assignee: Nanyang Technological University
    Inventors: Xiao Hu, Heng Yeong Lee
  • Patent number: 10973925
    Abstract: Disclosed are compositions and methods for identifying a solid tumor cell target. Compositions and methods for treating prostate cancer are also disclosed. Further, cancer therapeutic compositions comprising CT20p are disclosed. Nanoparticles that are conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein are disclosed.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: April 13, 2021
    Assignees: University of Central Florida Research Foundation Inc., Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Memorial Sloan Kettering Cancer Center
    Inventors: Annette Khaled, Jesus Manuel Perez Figueroa, Santimukul Santra, Charalambos Kaittanis, Oscar Santiesteban, Jan Grimm, Hampton Sessions
  • Patent number: 10967295
    Abstract: Methods for making high-purity LiFSI salts and intermediate products using one, the other, or both of a reactive-solvent removal/replacement method and an LiFSI purification method. In some embodiments, the reactive-solvent removal/replacement method includes using non-reactive anhydrous organic solvents to remove and/or replace one or more reactive solvents in a crude LiFSI. In some embodiments, the LiFSI purification method includes using anhydrous organic solvents to remove impurities, such as synthesis impurities, from a crude LiFSI. In some embodiments, crude LiFSI can be made using an aqueous-based neutralization process. LiFSI salts and products made using methods of the disclosure are also described, as are uses of such salts and products and electrochemical devices that include such salts and products.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: April 6, 2021
    Assignee: SES Holdings Pte. Ltd.
    Inventors: Rajendra P. Singh, Qichao Hu
  • Patent number: 10960000
    Abstract: The present invention relates to a composition comprising pharmaceutical active ingredients which are susceptible to, or have potential for, abuse. The invention provides an oral pharmaceutical composition comprising a first population of beads and a second population of beads. The first bead population comprises a pharmaceutically active ingredient susceptible to, or having the potential for, abuse. The second bead population comprises a gelling agent and a coating substantially surrounding the gelling agent, but containing no pharmaceutically active ingredient. The first bead population and the second bead population are physically separable, but visually indistinguishable to the naked eye. Upon ingress of water into the second population of beads, the gelling agent is caused to swell forming a viscous mass inhibiting or preventing the extraction of the active ingredient.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: March 30, 2021
    Assignee: RECRO GAINESVILLE LLC
    Inventors: Gurvinder Singh Rekhi, Richard Sidwell
  • Patent number: 10953043
    Abstract: Stabilized multi-component antimicrobial compositions for treating tissue diseases, infections or conditions include a first and second set of differently sized and/or differently shaped metal nanoparticles, and a stabilizing agent. Compositions and treatment methods may be used for treating tissue diseases, infections or conditions caused by microbial infections, such as bacteria, viral, and/or fungal infections, or for preventing the infection of a wound, such as a cut, abrasion, ulcer, lesion, sore, and the like. The compositions and treatment methods disclosed herein may also be used as a prophylactic, and in some embodiments may be applied to otherwise healthy tissue in order to prevent or reduce the occurrence of a tissue disease, infection or condition.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: March 23, 2021
    Assignee: ATTOSTAT, INC.
    Inventors: Bryon J. Tarbet, William H. Niedermeyer
  • Patent number: 10940336
    Abstract: A method of encapsulation of an active comprising (a) dispersing an active in an aqueous medium having a pH of less than 6; (b) causing the formation on this dispersed active of a polymer shell, the formation comprising the sequential deposition of a series of polymeric layers, each layer being capable of hydrogen bonding with the preceding layer; to form an aqueous slurry of active-containing capsules; characterised in that one of the first two layers is a polycarboxylic acid and that the first two to four layers taken together exhibit an interfacial compression dilation modulus of greater than 10 mN/m. The method allows the precise tailoring of polymeric shells, allowing capsules walls to be much thinner without a loss of strength. The technique is especially useful for the encapsulation of fragrances and flavours.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: March 9, 2021
    Assignee: GIVAUDAN SA
    Inventors: Stephane Bone, Cédric Geffroy, Sandrine Le Tirilly, Patrick Perrin, Claire Vautrin, Cècile Monteux, Nadége Pantoustier
  • Patent number: 10940456
    Abstract: Hydrogenated amorphous silicon-containing colloids or composite colloids have a silicon-containing shell which surrounds the hollow colloids or composite colloids. The colloids have a spherical geometry. The silicon-containing composite colloids have a spherical geometry and a diameter of between 2 nm and 7 nm in scanning electron micrographs, and the silicon-containing colloids have a spherical geometry with a cavity and a diameter of between 50 and 200 nm in scanning transmission electron micrographs. The cavity is surrounded by a shell with a thickness of between 3 and 10 nm.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: March 9, 2021
    Assignee: FORSCHUNGSZENTRUM JUELICH GMBH
    Inventors: Andrew Paolo Cadiz Bedini, Benjamin Klingebiel, Stefan Haas, Jan Flohre, Reinhard Carius, Chunguang Chen, Peter Notten
  • Patent number: 10933129
    Abstract: Disclosed are methods for generating humoral and cytotoxic T lymphocyte (CTL) immune responses in a subject and related compositions.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: March 2, 2021
    Assignee: Selecta Biosciences, Inc.
    Inventors: David H. Altreuter, Conlin O'Neil, Petr Ilyinskii
  • Patent number: 10926079
    Abstract: A nanodevice includes an array of metal nanorods formed on a substrate. An electropolymerized electrical conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open or close responsively to electrical signals applied to the nanorods. A cell loading region is disposed in proximity of the reservoir, and the cell loading region is configured to receive stem cells. A neurotrophic dispensing material is loaded in the reservoir to be dispersed in accordance with open pores to affect growth of the stem cells when in vivo.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: February 23, 2021
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Steven J. Holmes, Qinghuang Lin, Emily R. Kinser, Nathan P. Marchack, Roy R. Yu
  • Patent number: 10918852
    Abstract: A nanodevice includes an array of metal nanorods formed on a substrate. An electropolymerized electrical conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open or close responsively to electrical signals applied to the nanorods. A cell loading region is disposed in proximity of the reservoir, and the cell loading region is configured to receive stem cells. A neurotrophic dispensing material is loaded in the reservoir to be dispersed in accordance with open pores to affect growth of the stem cells when in vivo.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: February 16, 2021
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Steven J. Holmes, Qinghuang Lin, Emily R. Kinser, Nathan P. Marchack, Roy R. Yu
  • Patent number: 10905652
    Abstract: Therapeutic compositions deliver a therapeutic amount of methylphenidate in a delayed and extended release formulation. The dosage form exhibits a lag time prior to release of from 6 to 8 hours or longer, followed by a sustained release period.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: February 2, 2021
    Assignee: Ironshore Pharmaceuticals & Development, Inc.
    Inventors: David Lickrish, Feng Zhang
  • Patent number: 10898442
    Abstract: The invention provides a gelated mono-nuclear microencapsulate comprising a lipid emulsion core encapsulated within a gastro-resistant, ileal sensitive, polymerized chitosan membrane shell, wherein the lipid emulsion core comprises denatured or hydrolysed protein and carbohydrate. In one embodiment of the invention, the emulsion is a micro-emulsion, and typically comprises a surfactant and a co-surfactant or at least two carbohydrates, for example sucrose and a maltodextrin. In one embodiment of the invention, the lipid is a marine derived lipid such as fish oil, krill oil, or nutraceutical fatty acids. In other embodiment, the lipid is a fatty acid such as DHA or ARA, or a lipid derived from seeds, nuts or eggs.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: January 26, 2021
    Assignee: Anabio Technologies Limited
    Inventor: Sinead Bleiel
  • Patent number: 10894085
    Abstract: The system comprises a support to receive a nanoparticle assembly (NPA) and to be conveyed towards a localized area of an organism infected or at risk to be infected by microorganisms; said nanoparticle assembly (NPA) comprising a plurality of nanoparticles (NPs) each one (NP) having a metal core and a surface surrounding said metal core, the metal core being reactable to thermal energy; and an energy unit (15) configured to apply at least one thermal shot on said localized area exposed to the nano-particle assembly, increasing the temperature of said localized area via the. nanoparticle assembly (NPA), so enabling a nanotheranostic multimodal antimicrobial therapy, wherein the metal core being made of silver, gold, iron or a mixture of silver and gold.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: January 19, 2021
    Assignees: FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON—INSTITUT DE RECERCA, FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
    Inventors: Joan Gavalda Santapau, Victor Franco Puntes, Eduard Torrents Serra
  • Patent number: 10881618
    Abstract: Therapeutic compositions deliver a therapeutic amount of methylphenidate in a delayed and extended release formulation. The dosage form exhibits a lag time prior to release of from 6 to 8 hours or longer, followed by a sustained release period.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: January 5, 2021
    Assignee: Ironshore Pharmaceuticals & Development, Inc.
    Inventors: David Lickrish, Feng Zhang
  • Patent number: 10874622
    Abstract: Disclosed are nanoparticles for the delivery of a therapeutic agent or a diagnostic agent to a subject that include a chitosan and a polyphosphate, wherein the chitosan nanoparticles are coated with polylactic acid. Methods of delivering a therapeutic agent or a diagnostic agent to a subject for the treatment or prevention of a disease are also disclosed. For example, the treatment of ovarian cancer in a subject by inhibiting the expression of ZNF034 is disclosed.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: December 29, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Burcu Aslan, Gabriel Lopez-Berestein, Anil K. Sood
  • Patent number: 10869841
    Abstract: Methods, systems, and devices are disclosed for encapsulating biological entities with preservation of their biological activity. In one aspect, a method of encapsulating a biological entity includes templating a biocompatible material onto a biological structure to form a coating structure enclosing the biological structure, the coating structure having a size in the nanometer range, in which the coated biological structure preserves its biological activity within the coating structure. In some implementations of the method, the biological structure includes a virus and the biocompatible material includes silica.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: December 22, 2020
    Assignee: The Regents of the University of California
    Inventors: Inanc Ortac, Gen Yong, Michael Benchimol, Sadik C. Esener
  • Patent number: 10851547
    Abstract: Disclosed are methods to produce composite materials, which contain customized mixes of nano- and/or micro-particles with tailored electromagnetic spectral properties. In some defense-related applications, the use of such materials enables an improved spectral match between different structures, such as vehicles or buildings with the surrounding environment at least in the VIS and NIR wavelength range. This can camouflage the structures, and reduce the detectability thereof by ground-, air- or space-based multi-spectral long-range imaging systems, including aircrafts, drones, and satellites, and thus, generally delay, complicate, or eliminate detection or classification of the camouflaged structures.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: December 1, 2020
    Inventors: William Boone Daniels, II, Andreas Hieke
  • Patent number: 10850246
    Abstract: The invention provides a new method for preparing ultra-small polymeric-lipidic delivery nanoparticles (USDNs) that were synthesized by a nanoprecipitation method followed by a layer-by-layer nanodeposition. The USDNs particle size can be controlled between 5-25 nm and provides loading capacities of 22.12% to 72.08%. Moreover, the USDNs platform provides pH controlled drug release, within a terminal release ratio of 68% at pH 5.0 and almost no release to pH of 7.5. Furthermore, based on their small sizes (5-25 nm) and unique composition, the USDNs penetrates the skin strata efficiently, release the payload at the target site as topical or transdermal treatment of a variety of skin disorders. Additionally the USDNs system can be used to treat and diagnoses other crucial diseases (Cancer, Alzheimer, etc) can be combined with various micro-needles or needles free array technologies for special application.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: December 1, 2020
    Assignee: IndagoMed, LLC
    Inventor: Anamaria Orza
  • Patent number: 10835464
    Abstract: The present invention provides a sunscreen composition comprising cerium oxide (CeO2) particles surface-modified with a saturated fatty acid having 10 to 30 carbon atoms or an unsaturated fatty acid having 10 to 30 carbon atoms. Since the sunscreen composition according to an embodiment of the present invention exhibits a high kinematic viscosity in the low-frequency region and high-frequency region, the formulation has excellent emulsification/dispersion phase stability and excellent spreadability, and thus the sunscreen composition can be effectively used as a cosmetic composition for blocking ultraviolet rays.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: November 17, 2020
    Inventors: SeungHyun Lee, Seok Joo Kim
  • Patent number: 10799580
    Abstract: Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: October 13, 2020
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Robert Seder, Geoffrey Lynn, Leonard Seymour
  • Patent number: 10792085
    Abstract: The present disclosure relates generally to cryosurgery apparatuses and systems for and methods of treatment of distal lung tissue or lesions, and more particularly to guided cryogenic delivery to a distal treatment area within lung tissue via a low-profile, high pressure, closed-tipped catheter or probe configured to pass through a working channel of a bronchoscope and extend to a distal region of the lung.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: October 6, 2020
    Assignee: CSA Medical, Inc.
    Inventor: John P. O'Connor
  • Patent number: 10792649
    Abstract: The present invention provides machines, compositions and methods for producing bionanocatalysts (BNCs) comprising one or more enzymes selected from a broad spectrum of industrially and medically important enzymes. The BNCs are self-assembled and magnetically immobilized enzymes. The machines, compositions, and methods are fully scalable from bench top to industrial manufacturing volumes.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: October 6, 2020
    Assignee: Zymtronix, LLC
    Inventors: Stephane Corgie, Matthew Chun, Ricki Chairil, Rani Talal Brooks
  • Patent number: 10786596
    Abstract: In various aspects, the present disclosure pertains to methods of treating or preventing bleeding at a tissue site comprising applying a chitosan powder composition to the tissue site. In various aspects, the present disclosure pertains to chitosan powder compositions for application to a tissue site, where the powder compositions comprise a chitosan salt, a crosslinked chitosan, a derivatized chitosan, or a combination thereof. In various aspects, the disclosure pertains to catheter assemblies, which are preloaded with a chitosan powder composition and which are configured to deliver the chitosan powder composition a tissue site.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: September 29, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Gerald Fredrickson, Amanda L. Smith, Andrew Pic, Sophia Gervasio, Lauren Lydecker
  • Patent number: 10784011
    Abstract: A deformable yet mechanically resilient microcapsule having electrical properties, a method of making the microcapsules, and a circuit component including the microcapsules. The microcapsule containing a gallium liquid metal alloy core having from about 60 to about 100 wt. % gallium and at least one alloying metal, and a polymeric shell encapsulating the liquid core, said polymeric shell having conductive properties.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: September 22, 2020
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Brad L Cumby, Christopher Tabor
  • Patent number: 10758630
    Abstract: A topical composition includes a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein. The hydrophobic particles are derived from the same or different hydrophobic material and each hydrophobic particle has a melting point below the melting point of the respective hydrophobic material. The hydrophobic particles comprise a mean particle size of less than about 10 nm, and the nanoemulsion further includes one or more pharmaceutically active agents.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: September 1, 2020
    Assignee: The Johns Hopkins University
    Inventors: Jennifer L. Sample, Julia B. Patrone, Jason J. Benkoski, Jennifer L. Breidenich, Lisa A. Kelly, Huong Le, James C. Crookston, Marcia W. Patchan, Luis Garza, Xiomara Calderon-Colon, Joshua T. Wolfe, Mellisa L. Theodore, Amanda Nelson, Sewon Kang
  • Patent number: 10758563
    Abstract: The invention relates to an oral formulation for targeted delivery of cholestyramine to the colon, comprising a plurality of cholestyramine pellets that are coated with a colon release coating. The invention also relates to the use of this formulation in the treatment of bile acid malabsorption.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: September 1, 2020
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Nils Ove Gustafsson, Nils-Olof Lindberg, Jessica Elversson
  • Patent number: 10751289
    Abstract: Provided are core-shell particles which are kept stable in a solvent such as water for a long period. Each core-shell particle includes a core which contains a hydrophobic polymer having an anionic group and a shell which contains calcium phosphate. At least one of calcium atoms contained in calcium phosphate is chemically bonded to a functional group derived from the anionic group. In a method of manufacturing core-shell particles each core-shell particle includes a core which contains a hydrophobic polymer and a shell which contains calcium phosphate, the method includes the steps of: mixing a water-soluble organic solution which contains a hydrophobic polymer having an anionic group with a solution which contains calcium ion so as to obtain a first mixed solution; mixing the first mixed solution with a solution which contains phosphate ions so as to obtain a second mixed solution; and stirring the second mixed solution.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: August 25, 2020
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Fukue Nagata, Katsuya Kato, Masahiko Inagaki
  • Patent number: 10736943
    Abstract: A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in ?-sheet structure dominant silk microsphere structures having about 2 ?m in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: August 11, 2020
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Xiaoqin Wang
  • Patent number: 10729676
    Abstract: The invention is directed to opioid agonist peptides and their use.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: August 4, 2020
    Assignee: Protagonist Theraputics, Inc.
    Inventors: Sampath Kumar Anandan, Jie Zhang, Ashok Bhandari, Gregory Thomas Bourne, Brian Troy Frederick, Larry C. Mattheakis, David Liu, Mukund M. Mehrotra
  • Patent number: 10729673
    Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: August 4, 2020
    Assignee: Crititech, Inc.
    Inventors: Michael Baltezor, Joseph Farthing, Jake Sittenauer, Jahna Espinosa, Samuel Campbell, Matthew McClorey, Julia K. Fischer, Mark D. Williams, Gary E. Clapp
  • Patent number: 10729656
    Abstract: An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: August 4, 2020
    Assignee: OHEMO Life Sciences Inc.
    Inventors: Manish S. Shah, Ray J. Difalco
  • Patent number: 10729783
    Abstract: The present invention relates to hollow silica nanoparticles as a drug delivery system loading bioactive ingredients. Particularly, the present invention relates to silica nanoparticles comprising multi-layered silica shells with one or more bioactive ingredients encapsulated within and their applications in drug delivery; and processes of preparing the same.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: August 4, 2020
    Assignee: NATIONAL TAIWAN UNIVERSITY
    Inventors: Chung-Yuan Mou, Nai-Yuan Kou, Si-Han Wu, Yi-Ping Chen
  • Patent number: 10722471
    Abstract: The present invention relates to a solid unit oral dosage form comprising sacubitril and valsartan in a 1:1 molar ratio, preferably in the form of the so-called angiotensin receptor neprilysin inhibitor (ARNI) LCZ696, which is a complex salt hydrate of sacubitril, valsartan, and sodium ions, appropriate for use in pediatrics or other patients where low and individual dosing is required or who encounter problems with swallowing e.g. as a result of a disease or because of age, to the manufacture of said solid dosage form and to invention embodiments relating to therapy using said dosage form.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: July 28, 2020
    Assignee: Novartis AG
    Inventors: Gesine Winzenburg, Bernd Trueby, Fabian Chen, Surya Prakash Ayalasomayajula, Christopher Bush, Masha Berkhin
  • Patent number: 10710044
    Abstract: The invention relates to self-assembled architectures formed from polymer-lipid blends, and in particular, to tubular and vesicular self-assembled architectures formed from polymer-lipid blends. The invention further relates to a method for forming the tubular and vesicular self-assembled architectures. The invention provides a composition comprising a lipid and an amphiphilic block copolymer, wherein the amphiphilic block copolymer is capable of undergoing self-assembly to form an architecture of a first geometry, wherein the composition undergoes self-assembly to form a bilayer architecture enclosing a volume of a second geometry, wherein the second geometry is different from that of the first geometry.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: July 14, 2020
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Madhavan Nallani, Bo Liedberg, Atul Parikh, Hans-Peter De Hoog, Amit Kumar Khan, Seng Koon Lim
  • Patent number: 10709661
    Abstract: A particulate composition suitable for oral consumption comprising: a carrier phase which is a free flowing particulate phase comprising a poor or bitter tasting agent and a first particulate agent; and a retained phase comprising a second particulate agent, wherein the second particulate agent is or comprises a flavour agent and/or a taste-masking agent, and wherein the residence time in the mouth of the retained phase (R90: retained) is greater than the residence time in the mouth of the carrier phase (R90: carrier).
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: July 14, 2020
    Inventor: Andrew Guise
  • Patent number: 10709221
    Abstract: A tamperproof diamond package comprises a package body; at least one chip embedded in the package body and at least one antenna configured to enable communication with the chip; anti-counterfeiting visual impressions on the package body; a diamond pouch formed at a predetermined section within the package body; and one or more diamonds located inside the diamond pouch and an outer covering encasing the package body and configured to reveal any tampering with the one or more diamonds located in the diamond pouch. The diamond package can be credit card shaped and also contains serial number and website information and be provided in nominal dollar values. An associated diamond exchange system utilizes the diamond packages and provides a registration server which stores unique identifying information that enable interrogating the individual diamond packages and checking their authenticity with the registration server.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: July 14, 2020
    Assignee: DIAMOND STANDARD INC.
    Inventor: Cormac Kinney
  • Patent number: 10703954
    Abstract: Methods for treating a subterranean formation are described. The methods include providing a petrified cellulosic material, combining the petrified cellulosic material with a treatment fluid, and introducing the treatment fluid with the petrified cellulosic material in the subterranean formation.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: July 7, 2020
    Assignee: HALLIBURTON ENERGY SERVICES, INC.
    Inventors: Cato Russell McDaniel, Dale E. Jamison
  • Patent number: 10682409
    Abstract: This invention discloses a treatment for a patient receiving medication to treat an attention deficit disorder such as ADHD wherein the treatment results in a loss of appetite and impairment of the patient's attentiveness. The treatment combines a treatment for an attention deficit disorder with an appetite stimulant, wherein the appetite stimulant increases the caloric intake of a patient, which can increase the patient's attentiveness. The combination treatment can be given for an indefinite, including, without limitation, life-long, to allow a patient to maintain normal caloric intake during treatment for an attention deficit disorder.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: June 16, 2020
    Assignee: Attentive Therapeutics, Inc.
    Inventors: Douglas Sears, Michael Reilly
  • Patent number: 10682314
    Abstract: Disclosed herein are methods and compositions for treating or preventing swine influenza in a subject.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: June 16, 2020
    Assignee: Ohio State Innovation Foundation
    Inventors: Renukaradhya Gourapura, Santosh Dhakal, Jagadish Hiremath, Chang-Won Lee
  • Patent number: 10676701
    Abstract: A consumer product composition comprises a consumer product adjunct ingredient, a microcapsule, and deposition polymer disposed on an outer surface of the microcapsule. The deposition polymer has a Water Uptake Value (WUV) of at least about 2 grams per gram, as determined according to the WATER UPTAKE VALUE TEST METHOD. The microcapsule comprises a shell material encapsulating a core material, wherein the shell material comprises a polyacrylate and the core material comprises a benefit agent.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: June 9, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Hiroshi Oh, Dorothy A Hall, Pierre Verstraete, Olivier Fasbender, Johan Smets, Steven Daryl Smith
  • Patent number: 10646485
    Abstract: The present disclosure relates to cured pharmaceutical compositions designed to reduce the potential for improper administration of drugs that are subject to abuse, the process of curing such composition in order to improve the dissolution stability, method of using the same for treatment of pain.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: May 12, 2020
    Assignee: Collegium Pharmaceutical, Inc.
    Inventors: Said Saim, Alison B. Fleming, Ravi K. Varanasi
  • Patent number: 10632069
    Abstract: The present invention is directed to orally administered corticosteroid compositions. The present invention also provides a method for treating a condition associated with inflammation of the gastrointestinal tract in an individual. The method comprises administering to an individual in need thereof a pharmaceutical composition of the present invention.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: April 28, 2020
    Assignee: Adare Pharmaceuticals US, L.P.
    Inventors: Stephen Perrett, Fredric Jay Cohen, Gopi Venkatesh
  • Patent number: 10617651
    Abstract: Therapeutic compositions deliver a therapeutic amount of methylphenidate in a delayed and extended release formulation. The dosage form exhibits a lag time prior to release of from 6 to 8 hours or longer, followed by a sustained release period.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: April 14, 2020
    Assignee: IRONSHORE PHARMACEUTICALS & DEVELOPMENT, INC.
    Inventors: David Lickrish, Feng Zhang
  • Patent number: 10583282
    Abstract: A nanodevice includes an array of metal nanorods formed on a substrate. An electropolymerized electrical conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open or close responsively to electrical signals applied to the nanorods. A cell loading region is disposed in proximity of the reservoir, and the cell loading region is configured to receive stem cells. A neurotrophic dispensing material is loaded in the reservoir to be dispersed in accordance with open pores to affect growth of the stem cells when in vivo.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: March 10, 2020
    Assignee: International Business Machines Corporation
    Inventors: Steven J. Holmes, Qinghuang Lin, Emily R. Kinser, Nathan P. Marchack, Roy R. Yu
  • Patent number: 10576028
    Abstract: The present invention concerns a composition, in particular in the form of aqueous dispersion for caring for and/or making up keratin materials comprising, in a physiologically acceptable medium, a) one aqueous phase; and b) at least microcapsules comprising:—an inner core comprising at least a dispersion of at least one reflective agent, in particular bismuth oxychloride, in at least one oil, and—at least one outer shell formed of a wall-forming polymeric material surrounding the said core, the said outer shell comprising i) at least one wall-forming polymer, and ii) optionally at least one plasticizer and/or at least one opaque substance and/or at least one fatty acid salt. The present invention concerns also a cosmetic process for caring for and/or making up keratinic materials, comprising application on said keratinic materials in particular on the skin of a composition as above defined.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: March 3, 2020
    Assignee: L'OREAL
    Inventors: Audrey Ricard, Danny Goldstein
  • Patent number: 10576065
    Abstract: The present invention relates to a pharmaceutical composition containing rifaximin in the form of two different polymorphs as well as a method of preparing the same.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: March 3, 2020
    Assignee: Sandoz AG
    Inventor: Johannes Raneburger