Containing Polysaccharides (e.g., Sugars) Patents (Class 424/493)
  • Patent number: 10420804
    Abstract: This invention provides pharmaceutical compositions, including anti-gastrointestinal cancer compositions, containing propolis and cyclodextrin. Methods of using such compositions, in particular in the treatment or prevention of gastrointestinal cancers, and the resensitization of gastrointestinal cancers to therapy are also provided.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: September 24, 2019
    Assignee: Manuka Health New Zeland Limited
    Inventors: Kerry Paul, Owen John Catchpole, Darina Lazarova
  • Patent number: 10376592
    Abstract: An agent comprising: an algin crosslinked with acetal linkages; and at least one cation coupled to the crosslinked algin.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: August 13, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Abhinav Acharya, Stephen R. Little
  • Patent number: 10314786
    Abstract: Provided is a hydroxyalkyl alkyl cellulose exhibiting good flowability and high compressibility. More specifically, there are provided a hydroxyalkyl alkyl cellulose having a volume-based average particle size, determined by dry laser diffractometry, of more than 100 ?m and not more than 150 ?m; and after dividing all particles into fine particles, spherical particles and fibrous particles by a dynamic image analysis, a volume fraction of the fibrous particles relative to all of the particles of more than 40% and not more than 50%, and a volume fraction of the fine particles relative to all of the particles of less than 2.0%; a solid preparation including the hydroxyalkyl alkyl cellulose; and others.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: June 11, 2019
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Taishi Kitaguchi, Yasuyuki Hirama, Takuya Yokosawa, Akira Kitamura
  • Patent number: 10105197
    Abstract: A method of treating a periodontal pocket, comprising a step of administering one or more biodegradable compounds in a suitable carrier into the periodontal pocket, wherein the compound induces partial or total filling of the periodontal pocket for a period of time. Preferably, the biodegradable compound is Poly-L-lactic acid.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: October 23, 2018
    Inventor: Fernando Colon
  • Patent number: 10071040
    Abstract: The present disclosure relates to a cosmetic composition comprising, in a cosmetically acceptable aqueous medium, at least one cationic surfactant, at least one oxyethylenated ester of sorbitan and at least one non-silicone liquid fatty substance, the liquid fatty substance being present in an amount of less than 8% by weight relative to the total weight of the composition. Another aspect of the present disclosure relates to a cosmetic process for treating keratin materials, such as the hair. The compositions as disclosed herein have an improved conditioning effect, for instance by smoothing the tips of the hair and providing improved hair sheen.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: September 11, 2018
    Assignee: L'Oreal
    Inventors: Géraldine Fack, Véronique Mahe
  • Patent number: 10028903
    Abstract: Uniform, rigid, spherical nanoporous calcium phosphate particles that define an internal space and an amount of active agent present in the internal space are provided. Also provided are topical delivery compositions that include the active agent loaded particles, as well as methods of making the particles and topical compositions. The particles and compositions thereof find use in a variety of different applications, including active agent delivery applications.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: July 24, 2018
    Assignee: Laboratory Skin Care, Inc.
    Inventors: Tetsuro Ogawa, Akira Yamamoto
  • Patent number: 10010510
    Abstract: Described herein are oral pharmaceutical formulations comprising a core component and a coating composition applied on the core component. Also described is a process for producing said oral pharmaceutical formulations.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: July 3, 2018
    Assignee: SIEGFRIED AG
    Inventor: Pascal Christian Prinderre
  • Patent number: 10004682
    Abstract: The present invention provides methods for impregnating a porous carrier with an active pharmaceutical ingredient (“AP”), the methods comprising steps: a) dissolving at least one API in a solvent to form an API solution; b) contacting a porous carrier with the at least one API of step (a) in a contactor to form an API impregnated porous carrier; and c) drying the at least one API impregnated porous carrier.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: June 26, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Fernando J. Muzzio, Benjamin J. Glasser, Plamen I. Grigorov
  • Patent number: 9951147
    Abstract: There is provided a process for the preparation of purified ?-(1,3)-D-glucans, comprising the steps of providing an aqueous ?-(1,3)-D-glucan initial solution having a pH of above 11.0, filtering the aqueous ?-(1,3)-D-glucan initial solution to obtain a ?-(1,3)-D-glucan containing filtrate, adjusting the pH of the ?-(1,3)-D-glucan containing filtrate with an acid to a pH of below 5.0 to obtain an acidic ?-(1,3)-D-glucan solution, and heating the acidic ?-(1,3)-D-glucan solution to a temperature in the range of 60 to 160° C.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: April 24, 2018
    Assignee: Cargill, Incorporated
    Inventors: Jacques Mazoyer, Jean-Pierre Lhonneur
  • Patent number: 9789539
    Abstract: The present invention relates to a nanometal-flake graphite composite and a method of manufacturing the same, and more particularly, to a nanometal-flake graphite composite, in which nanometal-flake graphite, in which crystallized nanometal particles are highly densely bonded to the surface of flake graphite, is coated with polydopamine to form a polydopamine coating layer which significantly improves properties such as bonding properties between flake graphite basal planes, adhesiveness with other media, and dispersibility, and a method of manufacturing the nanometal-flake graphite composite.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: October 17, 2017
    Assignee: CHEORWON PLASMA RESEARCH INSTITUTE
    Inventor: Seong-In Kim
  • Patent number: 9730907
    Abstract: Disclosed are a microcapsule fat powder of ?3-enriched meat, egg and milk and its preparation method, and the powder includes a water-soluble wall material and an ?3 oil core material embedded in the wall material. The water-soluble wall material is prepared by mixing dextrin, water-soluble syrup, whey powder or chitosan with starch paste, and the ?3 oil core material is prepared by mixing linseed oil, deep sea fish oil or algae oil with a composite emulsifier which is stearic acyl lactylate. The microcapsule fat powder can be combined with intestinal and pancreatic lipases very easily to improve the digestion, absorption and utilization of ?3 oils.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: August 15, 2017
    Assignee: Singao (Xiamen) Agribusiness Development Co., Ltd.
    Inventors: Zhouwen Lai, Liang Zhang
  • Patent number: 9724296
    Abstract: An oral pharmaceutical composition in unit dose form, each unit dose comprising a lipophilic drug substance within a unitary carrier body, said body comprising a soft, chewable, gelled oil-in-water emulsion.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: August 8, 2017
    Assignee: VITUX GROUP AS
    Inventors: Tore Seternes, Kurt Ingar Draget, Ingvild Johanne Haug
  • Patent number: 9346766
    Abstract: Provided is a method for the synthesis of N-protected bis-3,6-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of ?-amino protected lysine in the presence of a catalyst selected from the group consisting of sulfuric acid, phosphoric acid, and phosphorus pentoxide.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: May 24, 2016
    Assignee: MannKind Corporation
    Inventors: John J. Stevenson, Destardi Moye-Sherman
  • Patent number: 9228184
    Abstract: Provided herein are human Toll-like receptor (TLR)-inhibitors and methods for use in individuals having an autoimmune disease or an inflammatory disorder. The TLR inhibitors of the present disclosure are polynucleotides comprising an inhibitory motif for one or more of TLR7, TLR8 and TLR9.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 5, 2016
    Assignee: Dynavax Technologies Corporation
    Inventors: Cristiana Guiducci, Karen L. Fearon, Franck Barrat
  • Patent number: 9192673
    Abstract: Fine dry particulate resveratrol compositions suitable for use in topical formulations, as well as methods of making the same, are provided. In the dry particulate resveratrol composition, the resveratrol active agent is associated with the particles, e.g., via entrapment in the pores of the particles and/or ionic binding and/or non-covalent binding to the surface of the particles and/or loosely associated with the particles. Also provided are topical formulations which include the dry particulate resveratrol compositions of the invention, and methods of using the same.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 24, 2015
    Assignee: Laboratory Skin Care, Inc.
    Inventor: Zahra Mansouri
  • Patent number: 9149552
    Abstract: Described are modulating coatings that are configured to provide an improved release profile of a volatile composition from a base material, wherein the modulating coating includes a barrier substance that is configured to hinder a release of the volatile composition through the modulating coating, and a hygroscopic substance that is configured to facilitate the release of the volatile composition through the modulating coating.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: October 6, 2015
    Assignee: EnviroScent, Inc.
    Inventors: Bao Trong Do, Eric Mehnert, Nicholas D. McKay, Jr., Candace Branch, Jeffrey Sherwood
  • Patent number: 9101541
    Abstract: The present invention discloses a stable solid pharmaceutical matrix composition comprising sirolimus or pharmaceutically acceptable salts thereof along with one or more sugars.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: August 11, 2015
    Assignee: Cadila Healthcare Limited
    Inventors: Sunilendu Bhushan Roy, Sushrut Krishnaji Kulkarni, Kiritkumar Maulik Panchal, Shubhashchandra Shailendra Mandge
  • Patent number: 9089518
    Abstract: Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: July 28, 2015
    Assignee: Allergan Industrie SAS
    Inventor: Pierre Lebreton
  • Patent number: 9089517
    Abstract: Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: July 28, 2015
    Assignee: Allergan Industrie SAS
    Inventor: Pierre Lebreton
  • Patent number: 9089519
    Abstract: Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: July 28, 2015
    Assignee: Allergan Industrie SAS
    Inventor: Pierre F. Lebreton
  • Patent number: 9056057
    Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: June 16, 2015
    Assignees: Kala Pharmaceuticals, Inc., The John Hopkins University
    Inventors: Alexey Popov, Elizabeth M. Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
  • Publication number: 20150147270
    Abstract: The present invention features, inter alia, constructs for the delivery of therapeutic and diagnostic agents to a patient. The constructs can include a nanoparticle, a targeting agent that specifically binds a targeted tissue or cell, a therapeutic moiety, and a hydrogel. The constructs can be used in the treatment and diagnosis of bowel diseases, including inflammatory bowel disease (IBD) and colon cancer. In one embodiment, the therapeutic agent is a nucleic acid that mediates RNA inhibition (RNAi), and the invention is directed to treatments for IBD that combine the positive aspects of such agents {e.g., siRNAs) with the safety of a biodegradable polymeric delivery system to facilitate specific targeting of colonic tissues and cells. As the constructs can be formulated for oral administration, they are well tolerated and offer advantages with regard to patient compliance.
    Type: Application
    Filed: May 18, 2013
    Publication date: May 28, 2015
    Inventors: Didier Merlin, Bo Xiao, Hamed Laroui
  • Publication number: 20150140106
    Abstract: An ophthalmic formulation that includes nanoparticles. Each nanoparticle includes a shell which encapsulates sulfated non-anticoagulant heparin (SNACH), with or without hydrophobic anti-angiogenesis Tyrosine Kinase inhibitors. The SNACH is ionically or covalently bonded to the shell. The shell includes a polymer selected from the group consisting of poly (lactic-co-glycolic acid) (PLGA), chitosan, chitosan-alginate, and NIPAAM-APMAH-AA, wherein NIPAAM is N-isopropyl acrylamide, APMAH is N-3-aminopropylmethacrylamide hydrochloride, and AA is acrylic acid. A method for treating an eye disease of a subject includes: administering to an eye of the subject a therapeutically effective amount of the ophthalmic formulation for treating the eye disease. The eye disease involves an ocular angiogenesis-mediated disorder.
    Type: Application
    Filed: October 29, 2014
    Publication date: May 21, 2015
    Inventor: Shaker A. Mousa
  • Publication number: 20150125538
    Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing enzymes embedded in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions including, but not limited to, hyperoxaluria, absorptive hyperoxaluria, enteric hyperoxaluria, primary hyperoxaluria, idiopathic calcium oxalate kidney stone disease (urolithiasis), vulvodynia, oxalosis associated with end-stage renal disease, cardiac conductance disorders, inflammatory bowel disease, Crohn's disease, ulcerative colitis, and patients who have undergone gastrointestinal surgery and bariatric surgery (surgery for obesity), and/or who have undergone antibiotic treatment.
    Type: Application
    Filed: October 27, 2014
    Publication date: May 7, 2015
    Applicant: OXTHERA INTELLECTUAL PROPERTY AB
    Inventors: Qingshan Li, Harmeet Sidhu
  • Patent number: 9011925
    Abstract: A method for preparing polysaccharide nanocomposite particles is provided. The method comprises providing a first solution comprising an active component and a polysaccharide; adding a cross-linking agent to the first solution to provide a second solution; and allowing the second solution to conduct the reaction to form polysaccharide nanocomposite particles. The polysaccharide nanocomposite particles thus prepared show good coating ratio and enhanced applicability. Also provided is a method for inducing cancer cell apoptosis in a subject, comprising administrating to the subject an effective amount of the polysaccharide nanocomposite particles.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: April 21, 2015
    Assignee: China Medical University
    Inventors: Chih-Wei Chou, Yueh-Hsiung Kuo, Chin-Heng Yang
  • Patent number: 9012363
    Abstract: A granular agrochemical composition is disclosed including a granular core material having a water soluble portion with a first coating layer applied on the surface of the core material and a second coating layer applied on the surface of the first coating layer. The first coating layer includes a wax composition having a biologically active ingredient incorporated therein and the second coating layer includes a polymeric composition. The granular agrochemical composition exhibits a controlled rate of release of the biologically active ingredient therefrom over a period greater than about 30 days from the date of initial exposure of the granular composition to moisture whereby essentially all of the biologically active ingredient incorporated in the wax material of the first coating layer is released from the granular composition before the water soluble portion of the granular core material is released from the granular composition.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: April 21, 2015
    Assignee: Everris International B.V.
    Inventors: Lonneke Jacoba van Boxtel-Verhoeven, Johannes Gijsbertus Antonius Terlingen, Petra Leonarda Hendrica Lunde-Vannuys
  • Publication number: 20150099002
    Abstract: The present invention relates to means and methods for enhancing intestinal function in poultry, leading to an increase in food conversion ratio and in total weight gain. Particularly, the present invention relates to insulin-containing feed formulations enhancing intestinal function and weight gain in poultry.
    Type: Application
    Filed: December 15, 2014
    Publication date: April 9, 2015
    Inventors: Naim Shehadeh, Lora Eshkar-Sebban, Aviv Hanien, Sharon Devir
  • Publication number: 20150093438
    Abstract: There is described a sub-analgesic amount of tramadol, or a salt thereof, in the treatment, alleviation or prevention of depression in a patient wherein the sub-analgesic amount is from about 60 to 80 mg, of tramadol or a salt thereof.
    Type: Application
    Filed: May 3, 2013
    Publication date: April 2, 2015
    Inventors: Malcolm Philip Young, Philip McKeown
  • Patent number: 8992987
    Abstract: Polysaccharide derivatives having a median Equivalent Projected Circle Diameter (EQPC) of less than 140 micrometers and a particle size and shape distribution meeting condition A or B or both are useful for preparing dosage forms, particularly for preparing compressed sustained-release dosage forms: A. non-compacted polysaccharide derivative particles have a flowability of at least 45 g/sec through a vertically inverted cone having a vertex angle of about 40 and an outlet diameter of about 50 mm, or B. i) no more than 40 volume percent of the polysaccharide derivative particles are fine particles having a particle length LEFI of less than 40 micrometers and ii) no more than 40 volume percent of the polysaccharide derivative particles are fibrous particles, and the sum of the fine particles and the fibrous particles does not exceed 50 volume percent.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: March 31, 2015
    Assignee: Dow Global Technologies LLC
    Inventors: Jennifer L'hote-Gaston, Nicholas S. Grasman, Jorg Theuerkauf, Sjoerd A. De Vries
  • Patent number: 8974831
    Abstract: Carrier particles in which at least 60% of the surface is coated with magnesium stearate are useful for preparing dry powder formulations for inhalation.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: March 10, 2015
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Rossella Musa, Daniela Cocconi, Alain Chamayou, Laurence Galet
  • Publication number: 20150064116
    Abstract: Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising a polynucleotide. Also provided are methods of using the compositions for transfection and/or transformation of a cell with the polynucleotide. Further provided are methods of detecting transfection of a cell with the polynucleotide.
    Type: Application
    Filed: September 28, 2012
    Publication date: March 5, 2015
    Applicant: University of South Florida (A Florida Non-Profit Corporation)
    Inventors: Subhra Mohapatra, Chunyan Wang
  • Patent number: 8962032
    Abstract: There is provided a method for suppressing a pro-inflammatory immune response in a cell, comprising providing to a cell sialic acid or analogs thereof, wherein the sialic acid or analogs are presented by a substrate such that a pro-inflammatory immune response in a cell is suppressed or an anti-inflammatory immune response is increased in a cell. Further, there is provided a method of treatment of inflammatory disease in a subject in need thereof. There is also provided a drug delivery device and a biomaterial which can modulate the inflammatory response in a subject.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: February 24, 2015
    Assignee: The Queen's University of Belfast
    Inventors: Christopher Scott, James Johnston, Shaun Spence, Danny McAuley, Francois Fay
  • Publication number: 20150050336
    Abstract: The present invention relates to taste masking system, taste masked formulations, dosage forms made from those formulations and methods of making those formulations that involve dissolving or dispersing a pH dependent polymer and a non-plasticizing active pharmaceutical ingredient in a solvent, granulating using that material or forming layers over a solid support therewith. This can be followed with the use of a taste masking overcoating layer.
    Type: Application
    Filed: October 7, 2014
    Publication date: February 19, 2015
    Inventors: Walid A. Habib, Derek V. Moe
  • Patent number: 8951564
    Abstract: The present invention relates to a galenic form comprising particles capable of specifically adsorbing the undesirable molecules present in the digestive tract, to the method for preparing same and to the use thereof in particular for producing a medicine intended for preventing or treating undesirable effects linked to an imbalance of the intestinal and/or colonic flora that can result for example from treatment with antibiotics.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: February 10, 2015
    Assignee: Centre National de la Recherche Scientifique—CNRS—
    Inventors: Elias Fattal, Nicolas Tsapis, Franceline Reynaud
  • Patent number: 8951554
    Abstract: A microcapsule, a structure including a microcapsule, an article including a microcapsule and a method of preparing microcapsules provided, the microcapsule includes at least one material selected from the group consisting of a magnetic substance, a dielectric substance and a combination thereof. The microcapsule also includes a volatile material.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: February 10, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Jong-jin Park, Jong-min Kim, Sung-ho Jin
  • Publication number: 20150030683
    Abstract: In certain embodiments the methods of preventing or delaying the onset of a pre-Alzheimer's condition and/or cognitive dysfunction, and/or ameliorating one or more symptoms of a pre-Alzheimer's cognitive dysfunction, and/or preventing or delaying the progression of a pre-Alzheimer's condition or cognitive dysfunction to Alzheimer's disease, and/or of promoting the processing of amyloid precursor protein (APP) by the non-amyloidogenic pathway are provided. In certain embodiments the methods involve administering, or causing to be administered, to a subject in need thereof certain formulations comprising or more active agent(s) selected from the group consisting of tropisetron disulfiram, honokiol, nimetazepam, and/or derivatives or analogs thereof.
    Type: Application
    Filed: February 15, 2013
    Publication date: January 29, 2015
    Inventors: Varghese John, Dale E. Bredesen, Stelios Tzannis
  • Publication number: 20150030684
    Abstract: An irrigation resistant bone repair composition including a biocompatible or bioactive bone repair material and a mixture of non-random poly(oxyalkylene) block copolymers is described. Also, methods for treating a bone having a bone gap or a bone defect with the composition including a biocompatible or bioactive bone repair material and a mixture of non-random poly(oxyalkylene) block copolymers are also provided. Also, kits including the irrigation resistant bone repair composition including a biocompatible or bioactive bone repair material and a mixture of non-random poly(oxyalkylene) block copolymers are described.
    Type: Application
    Filed: October 13, 2014
    Publication date: January 29, 2015
    Inventors: Gregory J. Pomrink, Cecilia A. Cao, Zehra Tosun, David M. Gaisser
  • Publication number: 20150024057
    Abstract: A method and composition are provided for coating a component to achieve colon-targeted delivery. A component is coated with a fructose-based non-digestible carbohydrate such as a inulin, fructo-oligosaccharide or neosugar. The coated component is orally administered to a monogastric animal. The non-digestible coating causes the composition to pass through the stomach and small intestine without being degraded, and delivers the component to the colon where the coating is digested by microbial fermentation and the component is released.
    Type: Application
    Filed: August 11, 2014
    Publication date: January 22, 2015
    Inventor: Guy W. Miller
  • Patent number: 8927025
    Abstract: This disclosure relates to an extended release oral dosage form comprising a matrix containing a viscosity modifier (but no lipid) and coated granules containing metoprolol or a pharmaceutically acceptable salt or solvate thereof. The dosage form has alcohol resistance and may also have crush resistance.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: January 6, 2015
    Assignee: Cima Labs Inc.
    Inventor: Ehab Hamed
  • Patent number: 8920781
    Abstract: A powder for use in a dry powder inhaler includes active particles and carrier particles for carrying the active particles. The powder further includes additive material on the surfaces of the carrier particles to promote the release of the active particles from the carrier particles on actuation of the inhaler. The powder is such that the active particles are not liable to be released from the carrier particles before actuation of the inhaler. The inclusion of additive material in the powder has been found to give an increased respirable fraction of the active material.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: December 30, 2014
    Assignee: Vectura Limited
    Inventor: John Nicholas Staniforth
  • Publication number: 20140377365
    Abstract: Provided herein are methods and compositions for producing formulations systemic delivery of dopamine agonists via the oral inhalation route. Specifically, provided herein are methods and compositions for a formulation of rotigotine that is suitable for administration via oral inhalation. Such methods and compositions are useful in the treatment or amelioration of one or more Parkinson's disease symptom(s).
    Type: Application
    Filed: June 18, 2014
    Publication date: December 25, 2014
    Inventors: Libo WU, Wiwik WATANABE
  • Publication number: 20140370111
    Abstract: Disclosed are methods and compositions of microbead carriers for delivery of cells and other biologically active substances to diseased or damaged tissue in a subject in need thereof.
    Type: Application
    Filed: November 23, 2011
    Publication date: December 18, 2014
    Inventors: Barbara Dale Boyan, Zvi Schwartz, Christopher S.D. Lee, Shirae Kerisha Leslie, Ramsey C. Kinney
  • Publication number: 20140363515
    Abstract: The present invention relates to a process for production of beadlets comprising hop acids salts in a matrix comprising at least one starch and/or starch derivative, to such beadlets and to the use of such specific beadlets.
    Type: Application
    Filed: December 28, 2012
    Publication date: December 11, 2014
    Inventors: Elger Funda, Dominique Joas
  • Patent number: 8900637
    Abstract: A stable taste masked, pharmaceutical composition comprising a plurality of coated, non-disintegrating discrete dosage units, said units comprising of a core comprising one or more cephalosporins such as cefuroxime axetil and cefpodoxime proxetil and one or more coating layers. Cefuroxime axetil is in ?-crystalline and amorphous forms, where at least 30% of the Cefuroxime axetil is in the ?-crystalline form, wherein the particle size distribution of the ?-crystalline form being such that 100% of the particles have a particle size below 250?. The ratio of the crystalline fraction to the amorphous fraction ranges from 0.3:0.7 to 0.99:0.01. The particle size of cefpodoxime proxetil is such that 90% of the particles are below 15?.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: December 2, 2014
    Assignee: Lupin Limited
    Inventors: Sachin Pundlik Kolhe, Subrata Kundu, Sanjay Chhagan Wagh, Makarand Krishnakumar Avachat, Himadri Sen
  • Publication number: 20140349850
    Abstract: The present invention relates to coated dehydrated microorganisms comprising a dehydrated microorganism surrounded by at least one coating, said coating comprising by dry weight at least 25% of hygroscopic salt(s) and wherein the pH of the coating is compatible with viability of the coated dehydrated microorganism. The coating can be partially crystalline, the salt(s) in the coating having preferably a crystallinity degree of up to 60% once applied onto the dehydrated microorganism. The present invention also relates to liquid coating compositions, methods for coating and protecting a dehydrated microorganism. Finally, the present invention relates to a method for the preparation of food products, feed products, consumer healthcare products or agri-products as well as to a food product, feed product, a consumer healthcare product or an agri-product containing such coated dehydrated microorganisms.
    Type: Application
    Filed: August 13, 2014
    Publication date: November 27, 2014
    Inventors: Isabelle Mazeaud, Kathryn Tse, Jean-Philippe Obert, Claudette Berger, Geoffrey Babin, Patrick Chaigneau, Hans Hedegaard Jensen, Erwan Henri
  • Patent number: 8895068
    Abstract: A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. A method of making the nanoparticle composition is also provided. The nanoparticle compositions provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: November 25, 2014
    Assignee: General Electric Company
    Inventors: Bruce Allan Hay, Brian Christopher Bales, Michael Todd Luttrell, Binil Itty Ipe Kandapallil
  • Publication number: 20140341996
    Abstract: Nanoengineering of inert polymers to develop functionalized sulfonated polymers to harness the power of Alternate complement system to stimulate and amplify cytotoxic potentials of classical and lectin based complement system Manufacturing functionalized sulfonated polymer to better penetrate tumor microenvironment, actively target various cancer antigens in conjunction with monoclonal antibodies in a safe way to inhibit host inflammatory reactions while maximizing cytotoxic potentials. The methods provide nanopolymers to safely maximize the cytotoxic potential of existing and evolving cancer therapies. Combining nanopolymers with existing and evolving cancer drugs to provide personalized cancer therapies.
    Type: Application
    Filed: May 13, 2014
    Publication date: November 20, 2014
    Inventor: Kumarpal A. Shah
  • Patent number: 8889189
    Abstract: There are described solid compositions or examining drug solubility comprising bile salts and phospholipids, optionally containing buffer components suitable for preparation of intestinal media that simulate the composition of the intestinal fluids in fasted and fed states.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: November 18, 2014
    Assignee: Phares Pharmaceutical Research, N.V.
    Inventors: Steve Leigh, Mathew Louis Steven Leigh, Peter Van Hoogevest, Daniel Streich, Jacques Quinton
  • Publication number: 20140335169
    Abstract: Acid-containing oral pharmaceutical compositions are provided wherein the pharmaceutical active agents are peptide compounds (i.e., those that include a plurality of amino acids and at least one peptide bond in their molecular structures). Certain barrier layers and/or particulate coated acid are used to reduce any adverse interactions that might otherwise occur between the acid of the compositions and other components of the composition. Use of these barrier layers and/or use of particulate coated acid is believed to promote a more simultaneous release of the components of the composition than is achieved by prior art acid-protection techniques, thus enhancing, and making more consistent, the bioavailability of the active peptide compounds.
    Type: Application
    Filed: January 17, 2014
    Publication date: November 13, 2014
    Applicant: Enteris BioPharma, Inc.
    Inventors: William Stern, Angelo P. Consalvo
  • Patent number: 8883218
    Abstract: The present invention encompasses a composition capable of delivering and expressing a nucleic acid encoding UDP-Glucuronosyltransferases, p53 or a combination thereof into a cell, and methods for treating tumors.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: November 11, 2014
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Anna Radominska-Pandya, Alexandru S. Biris