Containing Waxes, Higher Fatty Acids, Higher Fatty Alcohols, Or Derivatives Thereof Patents (Class 424/498)
  • Patent number: 10426754
    Abstract: Composition and method for treatment of Alzheimer's disease that includes ANAVEX2-73. Method of treatment of Alzheimer's disease using pharmaceutical compositions comprising ANAVEX2-73 according to an intermittent dosage regimen.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: October 1, 2019
    Assignee: ANAVEX LIFE SCIENCES CORP.
    Inventor: Marco Cecchi
  • Patent number: 10426728
    Abstract: The present disclosure relates to the synergistic liposomal formulation comprising, phophatidylcholine, stearylamine and anticancer drugs for the treatment of cancer. The PC:SA cationic liposome encapsulated camptothecin (CPT) and doxorubicin (DOX) formulations show enhanced synergistic anti-cancer effect and provide improved therapeutic index as compared to either the liposome or drug alone. The present disclosure also relates to the use of Cationic liposomal preparation of phosphatidylcholine:stearylamine (PC:SA) showing anticancer effect. The SA-bearing liposome and drug entrapped in the liposome are effective against cancer both in vitro and in vivo, without causing any adverse effect on host.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: October 1, 2019
    Assignee: Council of Scientific and Industrial Research
    Inventors: Nahid Ali, Manjarika De, Triparna Sen
  • Patent number: 10091993
    Abstract: There is provided a powder composition comprising a collection of particles (I) having median particle diameter of 10 micrometers to 200 micrometers, wherein each of said particles (I) comprises (a) a covering of a fatty compound having melting point of 50° C. to 110° C. and (b) one or more inner particles (II) comprising one or more complex that contains a cyclopropene compound molecule or a portion of a cyclopropene compound molecule encapsulated in a molecule of a molecular encapsulating agent. Also provided is a slurry comprising water and such a powder. Also provided is a method of contacting plants or plant parts with such a slurry.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: October 9, 2018
    Assignee: AGROFRESH INC.
    Inventors: Yueqian Zhen, Jeffrey A. Coles
  • Patent number: 10059635
    Abstract: The invention is directed towards methods and compositions for preventing dusting problems in mineral supplement. The method involves treating the mineral supplement or a dust releasing material with a composition comprising polymerized organic acid.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: August 28, 2018
    Assignee: Ecolab USA Inc.
    Inventors: Daniel N. T. Hay, Peter A. Dimas
  • Patent number: 9730440
    Abstract: There is provided a powder composition comprising a collection of particles (I) having median particle diameter of 10 micrometers to 200 micrometers, wherein each of said particles (I) comprises (a) a covering of a fatty compound having melting point of 50° C. to 110° C. and (b) one or more inner particles (II) comprising one or more complex that contains a cyclopropene compound molecule or a portion of a cyclopropene compound molecule encapsulated in a molecule of a molecular encapsulating agent. Also provided is a slurry comprising water and such a powder. Also provided is a method of contacting plants or plant parts with such a slurry.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: August 15, 2017
    Assignee: Agrofresh Inc.
    Inventors: Yueqian Zhen, Jeffrey A. Coles
  • Patent number: 9707240
    Abstract: The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a large lipid globule size. The composition can be used to prevent obesity and/or improve body composition later in life.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: July 18, 2017
    Assignee: N.V. Nutricia
    Inventors: Antonie Van Baalen, Eline Marleen Van Der Beek, Christopher Beermann, Günther Boehm
  • Patent number: 9700568
    Abstract: The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a lipid globules coated with polar lipids. The composition can be used to prevent obesity and/or improve body composition later in life.
    Type: Grant
    Filed: April 5, 2016
    Date of Patent: July 11, 2017
    Assignee: N.V. Nutricia
    Inventors: Eline Marleen Van Der Beek, Marieke Abrahamse-Berkeveld, Günther Boehm, Antonie Van Baalen
  • Patent number: 9675585
    Abstract: The present invention relates to coated extended release pharmaceutical formulations of valsartan comprising a core comprising valsartan and at least one coating layer over the core. The present invention further relates to extended release pharmaceutical formulations comprising (a) a core comprising valsartan and at least one hydrophilic swelling polymer and (b) at least one coating layer over the core wherein the coating layer in contact with the core is applied from an organic solvent based system.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: June 13, 2017
    Assignees: Ezra Pharma, Rubicon Research Private Limited
    Inventors: Joseph A. Fix, Shirish A. Shah, Pratibha S. Pilgaonkar, Anilkumar S. Gandhi
  • Patent number: 9662299
    Abstract: The present invention generally relates to yeast cell wall microparticles loaded with nanoparticles for receptor-targeted nanoparticle delivery. In particular, the present invention relates to trapping nanoparticles either on the surface or inside a yeast glucan particles, for example, yeast glucal particles. The present invention further relates to methods of making the yeast cell wall particles loaded with nanoparticles. The present invention also relates to methods of using the yeast cell wall particles loaded with nanoparticles for receptor-targeted delivery of the nanoparticles, e.g., drug containing nanoparticles.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: May 30, 2017
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Gary R. Ostroff, Ernesto Soto
  • Patent number: 9585925
    Abstract: This disclosure relates to methods of treating anal gland disease in subjects. In particular, the disclosure provides supplement compositions useful for treatment of anal gland disease. Such compositions comprise a probiotic, a fiber source, and an anti-inflammatory agent.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 7, 2017
    Assignee: Vetnique Labs LLC
    Inventor: Jamy A. Bascharon
  • Patent number: 9457022
    Abstract: The present invention relates to methods, compositions, and kits for treating or preventing symptoms of hormonal variation. The method comprises the steps of administering an effective amount of Dextromethorphan or Dextrorphan, or a pharmaceutically acceptable salt thereof, to a subject having one or more symptoms of hormonal variations.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: October 4, 2016
    Assignee: FERVENT PHARMACEUTICALS, LLC
    Inventor: George R. Royster, Jr.
  • Patent number: 9445996
    Abstract: Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of a least one microencapsulated nitrite salt and an activating volume of an aqueous acidified gel that has sufficient acidity to convert the nitrite salt to a nitric oxide (NO) and further provides a reducing property that retains the NO in bioactive form.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: September 20, 2016
    Assignee: NIOXX LLC
    Inventors: Cheng-Shing Chen, Ferid Murad, Kenneth A Smith, William A Seitz, William J Merrell, Alexandru T Balaban
  • Patent number: 9353301
    Abstract: The invention is directed towards methods and compositions for preventing dusting problems in mineral supplement. The method involves treating the mineral supplement or a dust releasing material with a composition comprising polymerized organic acid.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: May 31, 2016
    Assignee: Ecolab USA Inc.
    Inventors: Daniel N. T. Hay, Peter A. Dimas
  • Patent number: 9101547
    Abstract: The invention relates to an enteric-coated capsule containing cationic nanoparticles for oral insulin delivery, in particular to a type of cationic nanoparticle including a polycationic and mucoadhesive polymer and a biodegradable polymer, wherein each of the nanoparticles has positive surface charge and enhanced permeability for paracellular insulin delivery; the enteric-coated capsule further includes a pH-sensitive polymer as the coating. The enteric-coated capsule containing cationic nanoparticles, when being orally administered to a subject, are configured to prevent the acidic degradation of the active substance such as insulin before being released from said cationic nanoparticles to a specific absorption site along the gastrointestinal tract.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: August 11, 2015
    Assignee: NANO AND ADVANCED MATERIALS INSTITUTE LIMITED
    Inventors: Yu Qian, Li Juan Zhang, Zhi Min Wu, Li Ying Zhou, Wei Jiang, Li Ling, Qian Luo, Xin Dong Guo
  • Publication number: 20150147403
    Abstract: Compositions including at least 3?-tert-butyl-4?-(2-hydroxy-ethoxy)-4?-pyrrolidin-1-yl-[1,1?;3,1?]-terphenyl-4-carboxylic acid are described. The compositions can be oil-in-water emulsions made up of oily liquid globules each provided with a lamellar liquid crystal coating dispersed in an aqueous phase; a retinoid is either in the oily liquid globules or in the aqueous phase; each oily liquid globule is individually coated with a unilamellar or oligolamellar layer, obtained from at least one lipophilic surfactant, at least one hydrophilic surfactant and at least one separate anionic surfactant, and the coated oily liquid globules have a mean diameter lower than 800 nm.
    Type: Application
    Filed: May 30, 2013
    Publication date: May 28, 2015
    Inventor: Amel Djedour
  • Publication number: 20150118318
    Abstract: Compositions and methods for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder are described herein. The compositions contain a nanolipogel for sustained delivery of an effective amount of one or more active agents of choice, preferably a drug for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder. The nanolipogel includes a lipid bilayer surrounding a hydrogel core, which may optionally include a host molecule, for example, an absorbent such as a cyclodextrin or ion-exchange resin. In preferred embodiments at least one of active agents is an immunosuppressant.
    Type: Application
    Filed: April 12, 2013
    Publication date: April 30, 2015
    Applicant: Yale University
    Inventors: Tarek M. Fahmy, Michael Look, Joseph Craft
  • Publication number: 20150119961
    Abstract: The present invention discloses a heat therapy kit for malignant tumor treatment that comprises a pharmaceutical agent containing anti-regulatory T cell antibody and a pharmaceutical agent containing magnetic fine particles, and a heat therapy method that uses that kit.
    Type: Application
    Filed: December 19, 2014
    Publication date: April 30, 2015
    Inventors: Takeshi Kobayashi, Tomio Morino
  • Patent number: 9005666
    Abstract: A process for preparing nanocapsules with a liquid lipid core and a solid lipid shell, charged with at least one active agent. The process contains at least the steps of formulating a microemulsion by phase inversion of an emulsion, totally or partially forming from at least one active agent a second composition different than the microemulsion, placing the microemulsion in contact with the second composition under conditions suitable for interaction of the active agent with the microemulsion, and chill-hardening the microemulsion that has interacted with the active agent, to obtain the nanocapsules.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: April 14, 2015
    Assignees: L'Universite d'Angers, Inserm Transfert
    Inventors: Patrick Saulnier, Jean-Pierre Benoit, Nicolas Anton
  • Patent number: 8999686
    Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
    Type: Grant
    Filed: October 7, 2009
    Date of Patent: April 7, 2015
    Assignee: REG Life Sciences, LLC
    Inventors: Zhihao Hu, Vikranth Arlagadda
  • Patent number: 8986720
    Abstract: Disclosed is a topical skin care composition and corresponding methods for its use comprising water, a cationic surfactant, an occlusive skin conditioning agent, a humectant skin conditioning agent, and a silicone containing compound. The composition is dermatologically acceptable and is capable of moisturizing skin for at least twelve hours after topical application to skin even after multiple washings of the skin.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: March 24, 2015
    Assignee: Mary Kay Inc.
    Inventor: Bob Walke
  • Publication number: 20150064265
    Abstract: A “nanolipogel” is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or ion-exchange resin. Nanolipogels can be constructed so as to incorporate a variety of different chemical entities that can subsequently be released in a controlled fashion. These different incorporated chemical entities can differ dramatically with respect to size and composition. Nanolipogels have been constructed to contain co-encapsulated proteins as well as small hydrophobic drugs within the interior of the lipid bilayer. Agents incorporated within nanolipogels can be released into the milieu in a controlled fashion, for example, nanolipogels provide a means of achieving simultaneous sustained release of agents that differ widely in chemical composition and molecular weight. Additionally, nanolipogels can favorably modulate biodistribution.
    Type: Application
    Filed: April 12, 2013
    Publication date: March 5, 2015
    Inventors: Tarek M. Fahmy, Eric Stern, Richard A. Flavell, Jason Park, Alyssa Siefert, Stephen H. Wrzesinski
  • Publication number: 20150064263
    Abstract: Provided are compositions containing melatonin and zinc. Additionally provided are dosage forms containing the compositions, and methods of making the compositions and dosage forms. Methods of removing mercury from the body of subject are provided, as are methods of treating and/or preventing certain conditions associated with mercury toxicity.
    Type: Application
    Filed: May 25, 2011
    Publication date: March 5, 2015
    Inventor: David Kossor
  • Publication number: 20150064233
    Abstract: The invention provides nanoparticles containing a nucleic acid nanostructure, of defined shape and size, linked to a hydrophobic moiety and coated by lipids, compositions comprising the nanoparticles, and methods of producing and methods of using the nanoparticles.
    Type: Application
    Filed: March 13, 2013
    Publication date: March 5, 2015
    Applicant: President and Fellows of Harvard College
    Inventors: William M. Shih, Steven Perrault
  • Publication number: 20150064266
    Abstract: A pharmaceutical composition comprising an amphiphilic emulsifier, a polar liquid carrier and, optionally, a lipid component. The amphiphilic emulsifier form free-moving, optionally lipid-carrying, micelles (LMs) in the polar liquid carrier. The pharmaceutical composition is free of hemoglobin and fluorocarbon and can be used for treating conditions related to lack of blood supply and to raise the blood pressure and correct hypovolemia.
    Type: Application
    Filed: November 6, 2014
    Publication date: March 5, 2015
    Inventor: Cuthbert O. SIMPKINS
  • Publication number: 20150050354
    Abstract: The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides in the treatment, prevention and/or amelioration of otic diseases or conditions.
    Type: Application
    Filed: October 7, 2014
    Publication date: February 19, 2015
    Inventors: Axel Bouchon, Tirtha Chakraborty
  • Publication number: 20150037425
    Abstract: The present invention relates to pharmaceutical powders for inhalation produced by a method consisting of a first step of mixing particles of a force-controlling agent selected from a salt of a fatty acid with particles of one or more pharmacologically active materials and a second step of sieving or blending the powder with a carrier material.
    Type: Application
    Filed: September 22, 2014
    Publication date: February 5, 2015
    Inventor: Rudi Mueller-Walz
  • Publication number: 20150024060
    Abstract: The present disclosure describes economical processes to improve the bioavailability of nutraceuticals by formulations that induce micronization and sustained release. The inventive process can be used to increase the solubility and bioavailability of lipophilic and moderately water-soluble nutraceuticals by combining excipients that increase the solubility and induce sustained release of the active compounds. The inventive process also can be used to increase the residence time of highly water-soluble nutraceuticals that are metabolized and eliminated quickly from the body, consequently increasing the therapeutic potential. The disclosed formulations advantageously are freely flowing powders that can be used to formulate with other ingredients into tablets, capsules, or the like; or used as bulk powders.
    Type: Application
    Filed: September 12, 2014
    Publication date: January 22, 2015
    Applicant: BIOACTIVES LLC
    Inventors: Doddabele L. Madhavi, Daniel I. Kagan
  • Publication number: 20150017128
    Abstract: The present disclosure refers to strains of lactic bacteria and/or bifidobacteria having activity of inhibiting/reducing the growth of different biotypes of E. coli, including E. coli 0157:7 and different biotypes of clostridia, including Clostridium difficile, Listeria monocytogenes, Enterococcus sp. and Klebsiella sp. Furthermore, the present invention refers to a pharmaceutical or dietary composition or a supplement or a medical device with at least one of the said strains of bacteria, optionally in combination with acetylcysteine and/or microencapsulated gastroprotected lysozyme and/or acetylcysteine with microencapsulated gastro-protected lysozyme.
    Type: Application
    Filed: September 10, 2012
    Publication date: January 15, 2015
    Inventor: Giovanni Mogna
  • Patent number: 8927010
    Abstract: Therapeutic compositions and methods for treatment of attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD) include dosage forms that deliver a therapeutic amount of active drug in a delayed and controlled release formulation. The dosage form can be administered at night and drug release is delayed for from 4 to 6 hours or longer, followed by an ascending release rate.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: January 6, 2015
    Assignee: Ironshore Pharmaceuticals & Development, Inc.
    Inventors: David Lickrish, Feng Zhang
  • Publication number: 20140377365
    Abstract: Provided herein are methods and compositions for producing formulations systemic delivery of dopamine agonists via the oral inhalation route. Specifically, provided herein are methods and compositions for a formulation of rotigotine that is suitable for administration via oral inhalation. Such methods and compositions are useful in the treatment or amelioration of one or more Parkinson's disease symptom(s).
    Type: Application
    Filed: June 18, 2014
    Publication date: December 25, 2014
    Inventors: Libo WU, Wiwik WATANABE
  • Patent number: 8916214
    Abstract: A process is described for obtaining free flowable, carrier free powders from aqueous solutions of deliquescent quaternary ammonium compounds in a two step process, comprising a drying and a powder mixing step. The excellent free-flowing and stability characteristics of the final product could only be obtained when among possible other additives at least one univalent metal fatty acid salt is added to the liquid phase in the drying step and at least one multivalent metal fatty acid salt in the powder mixing step. A surprising synergy was observed between these additives when applied as described in the present invention.
    Type: Grant
    Filed: December 24, 2009
    Date of Patent: December 23, 2014
    Assignee: Taminco N.V.
    Inventors: Kristof Moonen, Daan Scheldeman
  • Patent number: 8916588
    Abstract: Therapeutic compositions and methods for treatment of attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD) include dosage forms that deliver a therapeutic amount of active drug in a delayed and controlled release formulation. The dosage form can be administered at night and drug release is delayed for from 4 to 6 hours or longer, followed by an ascending release rate.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: December 23, 2014
    Assignee: Ironshore Pharmaceuticals & Development, Inc.
    Inventors: David Lickrish, Feng Zhang
  • Patent number: 8900637
    Abstract: A stable taste masked, pharmaceutical composition comprising a plurality of coated, non-disintegrating discrete dosage units, said units comprising of a core comprising one or more cephalosporins such as cefuroxime axetil and cefpodoxime proxetil and one or more coating layers. Cefuroxime axetil is in ?-crystalline and amorphous forms, where at least 30% of the Cefuroxime axetil is in the ?-crystalline form, wherein the particle size distribution of the ?-crystalline form being such that 100% of the particles have a particle size below 250?. The ratio of the crystalline fraction to the amorphous fraction ranges from 0.3:0.7 to 0.99:0.01. The particle size of cefpodoxime proxetil is such that 90% of the particles are below 15?.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: December 2, 2014
    Assignee: Lupin Limited
    Inventors: Sachin Pundlik Kolhe, Subrata Kundu, Sanjay Chhagan Wagh, Makarand Krishnakumar Avachat, Himadri Sen
  • Patent number: 8901128
    Abstract: A novel controlled release pharmaceutical dosage form comprising a therapeutically effective amount of ranolazine or pharmaceutically acceptable salt(s), polymorph(s), solvate(s), hydrate(s), enantiomer(s) thereof, one or more lipid(s) as release controlling agent(s) and one or more pharmaceutically acceptable excipient(s).
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: December 2, 2014
    Assignee: Lupin Limited
    Inventors: Ketan Bhasale, Raghavendra Naik, Subhasis Das, Vijaya Kumar Thommandru
  • Patent number: 8895073
    Abstract: Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: November 25, 2014
    Assignee: Georgia Tech Research Corporation
    Inventors: Barbara D. Boyan, Robert E. Guldberg, Stephen J. Kennedy, David N. Ku, Zvi Schwartz
  • Publication number: 20140341963
    Abstract: A composition comprising at least one substance coated with an agent wherein the agent forms a liquid impermeable but gas permeable layer surrounding the said substance and preventing the passage of the said substance through said coating, wherein in-use the said substance is not released into solution in the body, and wherein said substance is selected from one or more of the group consisting of calcium phosphate, sodium chloride, potassium chloride, magnesium chloride, calcium carbonate, and sodium bicarbonate for use in the treatment of osteoporosis and other bone conditions.
    Type: Application
    Filed: May 9, 2014
    Publication date: November 20, 2014
    Applicant: ActiveSignal Holding Limited
    Inventor: Ward Warren
  • Patent number: 8889185
    Abstract: A modified release composition comprising tacrolimus which is useful for the treatment or prevention of rejection reactions by transplantation of organs or tissues.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: November 18, 2014
    Assignee: Veloxis Pharmaceuticals A/S
    Inventors: Per Holm, Tomas Norling
  • Patent number: 8883219
    Abstract: The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a lipid globules coated with phospholipids. The composition is used for increasing bone mineral content, bone mineral density, preventing osteoporosis, and/or preventing ostopenia.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: November 11, 2014
    Assignee: N. V. Nutricia
    Inventors: Eline Marleen Van Der Beek, Gelske Speelmans, Annemarie Oosting, Antonie Van Baalen, Marieke Abrahamse-Berkenveld, Günther Boehm
  • Patent number: 8877251
    Abstract: The present invention relates to methods of making a powder for inhalation comprising a first step of mixing particles of a force-controlling agent selected from the group consisting of phospholipids, titanium dioxide, aluminum dioxide, silicon dioxide, starch, and salts of fatty acids, with particles of one or more pharmacologically active materials, wherein the mixing is achieved by one or more of the processes of sieving, mixing or blending, and wherein the mixing results in the particles of the force-controlling agent being disposed on the surface of the particles of the one or more pharmacologically active materials as either a particulate coating or as a continuous or discontinuous film.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: November 4, 2014
    Assignee: Jagotec AG
    Inventor: Rudi Mueller-Walz
  • Publication number: 20140308360
    Abstract: The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for example, to inhibit a virus or bacteria from binding to a host cell. The inhibition can be used in therapy for the flu, cancer, or AIDS. The CRM particles can be used, for example, to prepare metal nanoparticles or metal alloy nanoparticles, or they can be used in catalytic reactions.
    Type: Application
    Filed: June 26, 2014
    Publication date: October 16, 2014
    Inventor: Yan Zhao
  • Publication number: 20140308343
    Abstract: The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially anti-tumoral agents, and the use thereof for the transport and vectorization of therapeutic agents, especially anti-tumoral agents.
    Type: Application
    Filed: March 13, 2014
    Publication date: October 16, 2014
    Applicants: UNIVERSITE VICTOR SEGALEN BORDEAUX 2, UNIVERSITE DE LA MEDITERRANEE, UNIVERSITE DE BOURGOGNE
    Inventors: Philippe BARTHELEMY, Michel CAMPLO, Nathalie CAMPINS, Bruno CHAUFFERT, Florence BOUYER
  • Publication number: 20140302156
    Abstract: The invention concerns a rigid shaped article essentially consisting of a plurality of mutually adhering grains of sand provided with a coating consisting of wax, for the elimination or relief of itching. In a particular embodiment of the invention, the wax essentially consists of beeswax.
    Type: Application
    Filed: August 25, 2011
    Publication date: October 9, 2014
    Inventor: Norbert Beermann
  • Publication number: 20140294927
    Abstract: Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent.
    Type: Application
    Filed: March 17, 2014
    Publication date: October 2, 2014
    Applicant: Northwestern University
    Inventors: C. Shad Thaxton, Chad A. Mirkin, Kaylin M. McMahon, Sushant Tripathy, Raja Kannan Mutharasan, David M. Leander, Andrea Luthi
  • Publication number: 20140294984
    Abstract: A process for producing a compacted rumen-protected nutrient pellet and the resultant pellet. The process includes the steps of (i) blending a C4-24 fatty acid and a biologically active ingredient to form solid central core particles, (ii) compacting the core particles to form pellets, and (iii) sequentially coating the pellets with an organic solvent and a fatty acid alkali metal or alkaline earth metal salt.
    Type: Application
    Filed: March 22, 2012
    Publication date: October 2, 2014
    Applicant: QUALI TECH, INC.
    Inventors: Jack Ellwyn Garrett, Greg Alan Nunnery, Michael John Hodgens
  • Publication number: 20140271899
    Abstract: The present invention provides methods and liposomal compositions useful in therapeutics, and diagnosis, prognosis, testing, screening, treatment and/or prevention of various disease conditions. The present invention provides imaging methods for various conditions. The present invention is a multi-layered drug delivery pathway, inclusive of nanoparticle liposomal formulations and mechanisms of localized action via unzipping upon delivery to the affected tissue site. The nano-encapsulation methodology allows maximization of a potent antioxidant's biocompatibility, increased target cell penetration and uptake, reduced off-target effects and retention of high anti-oxidative activity for promising therapeutic potential.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: PEROXYIUM, INC., DELAWARE C CORP.
    Inventors: James Leiter, Susan Gillmor, Aleksandar Jeremic, Ekaterina Vert-Wong, Gregg Fairbrothers
  • Publication number: 20140271890
    Abstract: The present invention relates to a controlled-release pharmaceutical composition which, when administered in the evening, promotes rapid sleep onset and makes it easy to wake up in the morning in a refreshing way. The composition comprises: a first portion having sleep-inducing activity, which is able to be degraded and absorbed in vivo within 5 minutes to 1 hour after administration; and a second portion having cognition-enhancing activity, which is able to be released in vivo after 4 to 8 hours from the start of absorption of the first portion. The composition, when administered in the evening, promotes rapid sleep onset and makes it easy to wake up in the morning in a refreshing way.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Inventor: Thaer Ahmad
  • Patent number: 8821935
    Abstract: The present invention is directed to microcapsules for reliably modified release and adapted to industrial reproduction of an active principle hardly water-soluble, other than anti-hyperglycemia agents. Each of said microcapsules comprises a core of hardly soluble active principle and a coating film applied on the core. Their mean diameter is less than 1000 microns. The coating film contains a film-forming polymer (PI) insoluble in gastrointestinal tract fluids, a water-soluble polymer (P2), a plasticizer (PL), and optionally a lubricating surfactant (TA). Said coating film represents at least 4% p/p of dry matter of their total weight, and its components P1, P2, PL satisfy the following characteristics: dry weight mass fraction of PI relative to the total coating weight ranging between 40 and 90%; dry matter weight fraction of PL/P1+P2 ranging between 15 and 60%; dry matter weight fraction of PL/P1+P2 ranging between 1 and 30%.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: September 2, 2014
    Assignee: Flamel Technologies
    Inventors: Florence Guimberteau, Catherine Castan, Rémi Meyruiex, Gérard Soula
  • Publication number: 20140242179
    Abstract: The present patent application relates to a novel coating system, coated compositions with such a coating system, as well as to the use of such compositions in the production food, feed, dietary supplements and/or pharmaceutical products, as well as to food, feed, dietary supplements and/or pharmaceutical products comprising such compositions.
    Type: Application
    Filed: October 11, 2012
    Publication date: August 28, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Sylvain Diguet, Bruno H. Leuenberger, Fabien Laboulfie, Mehrdji Hemati
  • Publication number: 20140234210
    Abstract: Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents.
    Type: Application
    Filed: July 9, 2012
    Publication date: August 21, 2014
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Wenbin Lin, Demin Liu, Joseph Della Rocca, Stephanie A. Kramer, Christopher Y. Poon
  • Publication number: 20140221961
    Abstract: A nano-carrier comprising an antiproliferative drug encapsulated by a lipophilic enhancement agent.
    Type: Application
    Filed: February 7, 2014
    Publication date: August 7, 2014
    Inventor: Juan Granada