Organic Sulfate Or Sulfonate Containing Patents (Class 424/56)
  • Publication number: 20100226865
    Abstract: A toothpaste composition comprising a surfactant, an abrasive, a humectant, triglyceride oil, a carboxylated polysaccharide, and a sulphated or sulphonated polysaccharide and the use of a sulphated or sulphonated polysaccharide, in particular a carrageenan, to improve the in-use foam quality of a toothpaste.
    Type: Application
    Filed: February 28, 2008
    Publication date: September 9, 2010
    Inventors: Ilaria Faravelli, Donald Peter Gregory, Irene Ingegneri
  • Publication number: 20100135929
    Abstract: An oral care composition comprising a fused silica abrasive and a gel network.
    Type: Application
    Filed: November 24, 2009
    Publication date: June 3, 2010
    Inventors: George Endel Deckner, Michael Jude LeBlanc, Lawrence Edward Dolan, Arif Ali Baig, Iain Allan Hughes
  • Patent number: 7674603
    Abstract: The invention relates to devices and methods for detecting and identifying microorganisms comprising a porous body having regions of differing pore size, said regions being associated with different chromogens specific to enzymes produced by microorganisms. Devices and methods according to the present invention may be useful in the detection and identification of food and water borne microorganisms as well as in the detection of bacteria that may be associated with infection, such as urinary tract infection.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: March 9, 2010
    Assignee: Prail Price Richardson Diagnostics Limited
    Inventors: Robert Graham Price, Nicola Karen Browne
  • Publication number: 20100008869
    Abstract: The present invention relates to a method of suppressing coloration of catechins, which contains adding, to catechins, a water-soluble polymer forming a water-insoluble complex with catechins, as well as hydrogel particles containing a water-insoluble complex between catechins and a polymer forming a water-insoluble complex with catechins. Further, the present invention relates to a dentifrice composition containing hydrogel particles containing catechins and a polymer forming a water-insoluble complex with catechins, a binder and water.
    Type: Application
    Filed: June 26, 2007
    Publication date: January 14, 2010
    Applicant: KAO Corporation
    Inventors: Michiya Takagi, Satoshi Ueno, Koji Mine, Hideaki Kubo, Ikuhisa Ichimura, Gen Nakauchi, Kazushi Oshino
  • Patent number: 7632525
    Abstract: An oral composition for oral cleansing, breath freshening, and anti-microbial benefits includes Magnolia Bark Extract in combination with a surface active agent. The effectiveness of Magnolia Bark Extract in inhibiting biofilm formation in the oral cavity is increased by a synergistic combination of the Magnolia Bark Extract with a surface active agent in an oral cavity delivery agent, such as chewing gum, a confectionary, a lozenge, a compressed tablet, and an edible film.
    Type: Grant
    Filed: July 14, 2005
    Date of Patent: December 15, 2009
    Assignee: Wm. Wrigley Jr. Company
    Inventors: Michael William James Dodds, James Roy Maxwell, Michael J. Greenberg, Minmin Tian, Rebecca Ann Aumann
  • Publication number: 20090269288
    Abstract: A proposed toothpaste is disclosed providing a synergistic composition for toothpaste to prevent decay, to prevent and control dental plague and gingivitis, and to suppress growth of wide spectrum of micro organisms that cause periodontal disease, while not exhibiting any harmful particular side effect. It allows absorbing and removing odor components out of the oral cavity for a long period of time, removing stain from the teeth, and polishing them. The toothpaste comprises: Sodium Monofluorophosphate, Glycerin, Water, Calcium Carbonate, Xylitol-70%, Sodium Dodecyl Sulfate, Sodium Saccharin, Sodium Bicarbonate, Sodium Methylparaben, Xanthan Gum (E-415), Cellulose Gum (E-466), Hydrated Silica, Titanium Dioxide (E-171), Peppermint Oil, Commiphora Myrrh Extract, Menthol, Charcoal, Grape Seed Oil, and Extract of Brazilian Acai Berry. Particular amounts of weight units for preferred embodiments are provided, as well as a sample method of preparation the toothpaste.
    Type: Application
    Filed: March 18, 2009
    Publication date: October 29, 2009
    Inventor: Zoya Lavrova
  • Publication number: 20090257963
    Abstract: A composition for measurably improving oral health, a system including the composition, a method of using the composition and system, and a method of forming the composition and system are disclosed. The composition is a gel that maintains contact with a portion of an oral cavity for an extended period of time to, for example, prevent or reduce plaque and calculus buildup. The system includes a composition and a container encapsulating the composition. The composition is applied by rupturing the container and applying the composition through the ruptured portion of the container. In exemplary embodiments, the methods, systems and kits disclosed herein are suitable for measurably reducing an amount of gingivitis, periodontitis, bleeding, plaque and/or tartar.
    Type: Application
    Filed: May 15, 2007
    Publication date: October 15, 2009
    Applicant: ZICARE, LLC
    Inventors: Tim Clarot, Regina Miskewitz
  • Patent number: 7485183
    Abstract: Pigment mixtures which have at least two components, where component A comprises effect pigments based on glass flakes and component B comprises flake-form, needle-shaped, spherical or crystalline colorants or fillers, and to the use thereof, in particular in cosmetic formulations and for the coloring or as a coating of products in the foods and pharmaceuticals sector are described.
    Type: Grant
    Filed: March 29, 2004
    Date of Patent: February 3, 2009
    Assignee: Merck Patent GmbH
    Inventors: Veronika Hochstein, Sabine Schoen
  • Publication number: 20080268001
    Abstract: The invention includes an oral care composition that reduces and/or eliminates the perception of tooth sensitivity. The composition includes an adherent material and silica particles having an average particle size of about 8 microns or less. The silica particles are present in the composition in an amount of about 5% by weight. Also included within the scope of the invention are related methods, such as methods of occluding a dentin tubule.
    Type: Application
    Filed: April 30, 2007
    Publication date: October 30, 2008
    Inventors: Lynette Zaidel, Suman K. Chopra, Michael Prencipe, Qin Wang, Constantina Christopoulou
  • Publication number: 20080008729
    Abstract: The present invention relates to flavor oils including mint-, fruit- and spice-type flavors that are specially processed to substantially eliminate low-molecular weight sulfur compounds, in particular dimethyl sulfoxide (DMSO), which has been found to be the main precursor of malodorous species such as dimethyl sulfide and methyl mercaptan. These malodorous species are produced via oxidation-reduction reactions involving such sulfur-containing compounds present in flavor oils. A preferred processing method is an aqueous-washing process, which has advantages of being simple, inexpensive and easy to implement while importantly avoiding the problems of typical processes including non-selective removal of desirable components and subjecting the flavor oils to extreme conditions that may destroy other components and result in undesirable changes in flavor or odor character.
    Type: Application
    Filed: July 5, 2007
    Publication date: January 10, 2008
    Inventors: Robert Leslie Swaine, Marc Hester, Steve Hoke, Denise McClenathan, Niranjan Ramji, Gerhard Norbert Zehentbauer
  • Patent number: 7192573
    Abstract: There are provided oral mouth rinse compositions, consisting essentially of: a) 1–20 wt % of an orally acceptable peroxide, b) 0.5–15 wt % of an orally acceptable sulfate, bisulfate, pyrosulfate salt of an inorganic cation or mixtures thereof, and c) water to 100 wt %. There are further provided methods of preparing and using said compositions as well as kits for maintaining the components to prepare said compositions.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: March 20, 2007
    Inventors: Leonard Mackles, William S Bess
  • Patent number: 7166272
    Abstract: An oral composition comprising 0.5 to 10% by weight of an abrasive precipitated silica having a 50 percentile (d50) of particle diameter being 5 ?m or less, a 90 percentile (d90) of particle diameter being 15 ?m or less and an RDA value of 120 or more, and 0.01 to 5% by weight of at least one of sulfosuccinate surfactants represented by general formula (1): [wherein either X1 or X2 is R1O—(AO)n— or the like and the other is M2O—; M1 and M2 are the same or different and each represent hydrogen, alkali metal, etc.; R1 is C8-22 alkyl, etc.; AO is C2-3 oxyalkylene and the average number of moles of AO addition polymerization, “n”, is 0 to 20; and B is —NH— etc.
    Type: Grant
    Filed: July 5, 2002
    Date of Patent: January 23, 2007
    Assignee: Sunstar Inc.
    Inventor: Koichi Fujisawa
  • Patent number: 6942848
    Abstract: Oral rinse and dentifrice compositions, comprising a phenolic selected from the group consisting of menthol, eucalyptol, methyl salicylate, thymol, triclosan, and mixtures thereof; and a cyclodextrin selected from the group consisting of hydroxypropyl ?-cyclodextrin, hydroxyethyl ?-cyclodextrin, hydroxypropyl ?-cyclodextrin, hydroxyethyl ?-cyclodextrin, ?-cyclodextrin, methyl ?-cyclodextrin, and mixtures thereof. These compositions are useful in retarding the development of plaque, treating gingivitis, and in treating the presence of micro-organisms in the oral cavity.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: September 13, 2005
    Assignee: Warner-Lambert Company LLC
    Inventors: Dennis George Anthony Nelson, Craig Joseph Sheehan
  • Patent number: 6927053
    Abstract: A two component desensitizing dentifrice composition is disclosed which comprises a first dentifrice component containing an enzyme such as papain and a second dentifrice component containing an ionic surfactant such as sodium lauryl sulfate, the first and second dentifrice components being maintained separate from the other until dispensed for application to teeth whereby enzyme activity is maintained with improved dentifrice foaming characteristics.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: August 9, 2005
    Assignee: Colgate-Palmolive Company
    Inventors: Malcolm Williams, Michael Prencipe, James G. Masters
  • Patent number: 6899865
    Abstract: An oral composition comprises water and a cyclic carbonate compound in a certain ratio. In this case, the ratio of the water and the cyclic carbonate compound is such that when the water and the cyclic carbonate compound are mixed together the mixture goes into a 2-phase state. Moreover, the oral composition may further comprise a polyol, and in this case the ratio of the water, the cyclic carbonate compound and the polyol is such that when the water, the cyclic carbonate compound and the polyol are mixed together the mixture goes into a 2-phase state. The oral composition has an excellent effect of removing accumulations on dental surfaces or between teeth through a physico-chemical action, rather than relying purely on a mechanical action.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: May 31, 2005
    Assignee: Kao Corporation
    Inventor: Yoshiyuki Eshita
  • Patent number: 6723304
    Abstract: The invention relates to oral care compositions such as toothpaste, gels, tooth powders, mouthwashes, mouth rinses, gums, mouth sprays and lozenges comprising diglycerol. The diglycerol is used as a humectant in the compositions. The compositions may further comprise water, flavoring agents, active compounds, emulsifier, alcohol, sweeteners, thickening agents, surfactants, suspending agents, astringent and toning drug extracts, flavor correctants, abrasives or polishes, deodorizing agents, preservatives, flavoring buffers, whitening agents, wound-healing and inflammation inhibiting substances, colorants, dyes, pigments, abrasives, polishes, antimicrobial agents, pH buffers and other additives and fillers.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: April 20, 2004
    Assignee: Noville, Inc.
    Inventor: Roger E. Stier
  • Patent number: 6719995
    Abstract: Systems for delivering cosmetic and therapeutic actives to the oral cavity employ a strip comprising a first layer of material, a second layer comprising polybutene with a molecular weight of about 300 to about 3000, and a cosmetic or therapeutic active included within the second layer. Therapeutic and cosmetic actives in compositions comprising polybutene inhibit or prevent gingivitis, caries, staining, fungi, bacteria and plaque build-up in the oral cavity by means of the delivery system.
    Type: Grant
    Filed: December 18, 2002
    Date of Patent: April 13, 2004
    Assignee: The Procter & Gamble Company
    Inventors: Jayanth Rajaiah, Lisa Catron Ernst, Ann Maria Case, Thinh Nguyen Ha, William Michael Glandorf, Christopher Robert Mayer
  • Patent number: 6703000
    Abstract: A confectionery composition comprising: (i) an effective amount of a natural plant extract selected from tea, gold thread, honeysuckle, magnolia extracts and mixtures thereof; (ii) an oral care active selected from the group consisting of anti-calculus agents; anti-plaque agents; fluoride ion source; desensitising agents; oral malodour control agents; H2 antagonists; and mixtures thereof; (iii) less than about 10% water; and (iv) a suitable confectionery carrier material.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: March 9, 2004
    Assignee: The Procter & Gamble Co.
    Inventors: Ji Ning, Thomas Mark Lawlor, Zhu Long
  • Patent number: 6656454
    Abstract: Aqueous oral and dental care compositions are comprising of: (a) from about 0.1 to about 20% by weight of surfactant granules which are the product of the process which comprises subjecting an aqueous paste comprised of from about 40 to about 60% by weight of a monoglyceride (ether) sulfate to simultaneous drying and granulation in a fluidized bed; (b) from about 1 to about 25% by weight of an abrasive, a polish, or a combination thereof; (c) from 0 to about 65% by weight of a humectant; (d) from 0 to about 2% by weight of chitosan; (e) from 0 to about 3% by weight of a flavoring and; (f) from 0 to about 5% by weight other auxiliaries including water wherein the weight of all components adds up to 100% by weight.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: December 2, 2003
    Assignee: Cognis Deutschland GmbH & Co. KG
    Inventors: Josef Koester, Werner Seipel, Celia Kosboth, Hermann Hensen, Anke Eggers
  • Patent number: 6610759
    Abstract: An adhesive composition that includes a mixture of a cationically polymerizable component, an acidic component, and an initiator is provided. Preferably, the initiator comprises an iodonium salt, a visible light sensitizer, and an electron donor compound, wherein the initiator has a photoinduced potential greater than or equal to that of N,N-dimethylaniline in a standard solution of 2.9×10−5 moles/g diphenyl iodonium hexafluoroantimonate and 1.5×10−5 moles/g camphorquinone in 2-butanone. This adhesive composition is cationically polymerizable and is able to bond to hard tissue and cationic restorative materials upon curing.
    Type: Grant
    Filed: March 6, 2000
    Date of Patent: August 26, 2003
    Assignees: Curators of the University of Missouri, 3M Innovative Properties Company
    Inventors: Cecil C. Chappelow, Charles S. Pinzino, J. David Eick, James Code, Joel D. Oxman, Sharon M. Rozzi
  • Patent number: 6558652
    Abstract: A particulate glucomannan gel is produced by swelling a glucomannan-rich flour with water in the presence of ethanol, treating the swollen particles with an alkali to form gelled particles followed by drying. The dried gel particles are incorporated into hygenic or cosmetic preparations as a deposit-cleaning agent.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: May 6, 2003
    Assignee: Shimizu Chemical Corporation
    Inventor: Tadahiko Takata
  • Patent number: 6468549
    Abstract: The invention relates to a cosmetic or dermatological composition containing an acidic aqueous medium and at least one crosslinked poly(2-acrylamido-2-methylpropanesulfonic acid) polymer neutralized to at least 90%. The composition contains, distributed randomly: (a) from 90 to 99.9% by weight of units of formula (1); and in which X+ denotes a cation or a mixture of cations, it being possible for at most 10 mol % of the cations X+ to be protons H+; (b) from 0.01 to 10% by weight of crosslinking units originating from at least one monomer having at least two olefinic double bonds; the proportions by weight being defined with respect to the total weight of the polymer. The invention also relates to the use of this composition in the cosmetic treatment of keratinous substances, in particular of the skin, hair and mucous membranes, and in particular to a non-therapeutic process for depigmentation of the skin.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: October 22, 2002
    Assignee: L'Oreal
    Inventors: Christine Dupuis, Isabelle Hansenne, Mirelle Maubru, Laurence Sebillote-Arnaud, Raluca Lorant
  • Patent number: 6419902
    Abstract: Disclosed is a color changing toothpaste which contains color reagents for interacting to provide a color change indicative of tooth brushing time. The color reagents comprise two separate color components which may be an FD&C dye, and FD&C lake or a natural food color, the two separate color components being adapted to interact after a predetermined brushing time to produce a third color. Optionally, the toothpaste may contain up to approximately 0.05% by weight of a foaming agent and other components such as a fluoride and a flavoring agent or flavor burst component.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: July 16, 2002
    Inventor: Howard W. Wright
  • Patent number: 6296834
    Abstract: The invention provides for an oral care composition which contains a non-cationic, water-insoluble or sparingly water-soluble antimicrobial agent, and an alkalimetal, ammonium or substituted ammonium alkylsulphate which contains a straight-chain, saturated or unsaturated C10 alkyl group.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: October 2, 2001
    Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.
    Inventors: Laurence Marie Bernard, Alison Katharine Green, Elizabeth Sarah Mountney
  • Publication number: 20010021511
    Abstract: This invention provides methods, reagents, and kits that are useful for diagnosing infection by E. histolytica. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, that bind to the 29 kDa antigen of E. histolytica.
    Type: Application
    Filed: January 17, 2001
    Publication date: September 13, 2001
    Applicant: Biosite Diagnostics
    Inventors: Gunars E. Valkirs, Joe Buechler, Jeff Gray
  • Patent number: 6126922
    Abstract: Dental compositions are provided comprising a) a polymerizable component, b) a fluoride-releasing material, c) a hydrophilic component, d) a polymerization initiator, and e) an acidic component. This dental composition is substantially free of added water, and has a Water Uptake Value of at least about 1.5 g of water per 100 g composition in 2 weeks. Compositions are also provided that comprise a) a polymerizable component, b) acid reactive filler, c) a hydrophilic component, d) a polymerization initiator, and e) an acidic component. The above materials are provided in amounts sufficient that the resulting composition has extremely desirable rheological properties.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: October 3, 2000
    Assignee: 3M Innovative Properties Company
    Inventors: Sharon M. Rozzi, Sumita B. Mitra, Bing Wang
  • Patent number: 6086856
    Abstract: Oral hygiene formulations comprising foaming surfactants are dispensed in the form of foams by means of an air-driven propellantless dispenser. The formulations comprise mouthwashes, rinses and dentifrices containing one or more antimicrobial anti-plaque and anti-cariogenic agents.
    Type: Grant
    Filed: September 19, 1995
    Date of Patent: July 11, 2000
    Assignee: OralCare Systems, Inc.
    Inventors: Albert Saferstein, Gary Gerard Fores
  • Patent number: 6013246
    Abstract: A preparation for inhibiting the release of mercury or to render mercury that is released when treating amalgam dental fillings or when inserting new amalgam fillings, harmless. The preparation contains at least 0.01 percent by weight of a physiologically acceptable organic sulphur compound, which includes at least one group chosen from SH and R.sub.1,-S.sub.n,-R.sub.2, where n=1--6. The use of such a preparation in mouth washes, mouth sprays, toothpastes, dental prophylactic pastes or rinsing/cooling liquids intended for use when drilling, abrading, polishing or cleaning with the aid of dental instruments. A therapeutic treatment preparation may include cysteine for rendering Hg harmless in solution form and/or gas form in the oral cavities of human beings and animals.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: January 11, 2000
    Assignee: CTC Medical AB
    Inventor: Sven Langworth
  • Patent number: 6008172
    Abstract: An aqueous-based, pleasant tasting, non-toxic bubble-making composition of at least one surfactant, at least one bubble-stabilizer functionally compatible with the selected surfactant(s) and other constituents of the composition, appearing in quantities relative to each other and the composition as a whole sufficient to produce bubbles of the desired form, size and stability but non-toxic if consumed orally in substantial quantities by a child, and at least one taste-enhancing agent functionally compatible with the composition as a whole in quantities relative thereto to produce a bubble-making composition which is relatively pleasant tasting.
    Type: Grant
    Filed: January 19, 1996
    Date of Patent: December 28, 1999
    Inventors: Oded Broshi, Robert W. Hartley, Richard J. Vetrone
  • Patent number: 5980869
    Abstract: The present invention relates to an oral formulation contained in physically separated compartments of a suitable dispenser, comprising a first oral composition comprising from about 0.5% to about 50% of an alkali metal bicarbonate salt and from about 50% to about 99.5% of one or more aqueous carriers; and a second oral composition comprising a safe and effective amount of a plant species of the Ericaceae family or its extract and from about 40% to about 99.9% of one or more aqueous carriers.
    Type: Grant
    Filed: April 28, 1997
    Date of Patent: November 9, 1999
    Assignee: The Procter & Gamble Company
    Inventors: Lowell Alan Sanker, Stephen James Nilsen
  • Patent number: 5942478
    Abstract: This invention relates to microbicidal and sanitizing soap compositions. More particularly, the invention relates to microbicidal and sanitizing soap compositions that incorporate agents with tuberculocidal properties in ready-to-use form that has gel properties or thixotropic-properties and to soap concentrate compositions suitable for dilution in or with water or non-aqueous diluent to produce gel-like or thixotropic solutions or dispersions ranging from free flowing to solidified forms. The ready-to-use compositions and the concentrate compositions are applied for purposes of personal or animal hygiene or sanitizing on hair, hands and skin or other body parts, or are applied on inanimate surfaces and objects that need to be sanitized.
    Type: Grant
    Filed: September 4, 1997
    Date of Patent: August 24, 1999
    Inventor: John A. Lopes
  • Patent number: 5932193
    Abstract: Disclosed are toothpaste compositions and a process for preparing such compositions comprising dental abrasive, humectant, fluidized polymer suspension and a suitable vehicle for the humectant, wherein the fluidized polymer suspension comprises: polyethylene glycol, carboxymethyl cellulose and hydrated thickening silica.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: August 3, 1999
    Assignee: Hercules Incorporated
    Inventors: Jean-Paul Lopez, Mohand Melbouci, Gerhard Dewald
  • Patent number: 5879663
    Abstract: There is provided a dental composition for relieving dentin hypersensitivity, which occludes dentinal tubules having an opening on the surface of dentin to relieve dentin hypersensitivity thereby to give an immediate relieving effect and to maintain the relieving effect for a long time.The dental composition for relieving dentin hypersensitivity, which comprises (A) a low molecular weight compound which can produce a precipitate which is hardly soluble in water when it reacts with a calcium compound, or which comprises the above component (A), (B) a calcium compound and/or (C) an aqueous polymer emulsion having a particle size smaller than that of a dentinal tubule and forming an agglomerate or a hardly soluble gel larger than the diameter of a dentinal tubule when it reacts with a calcium compound.
    Type: Grant
    Filed: August 7, 1996
    Date of Patent: March 9, 1999
    Assignees: Sun Medical Co., Ltd., Nobuo Nakabayashi
    Inventors: Nobuo Nakabayashi, Takashi Yamamoto, Yasukazu Saimi, Masami Arata, Harumi Tanaka
  • Patent number: 5876701
    Abstract: A striped and/or speckled dentifrice stable to color bleeding, wherein at least one dentifrice component contains a colorant entrained in a high density polyethylene matrix having a melting point range as measured by DSC is between about 110.degree. C. and about 145.degree. C., whereby on storage substantially no visually observable colorant bleeding is present in any other dentifrice component.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: March 2, 1999
    Assignee: Colgate Palmolive Company
    Inventors: Mike Wong, Michael Prencipe
  • Patent number: 5853703
    Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.
    Type: Grant
    Filed: January 18, 1996
    Date of Patent: December 29, 1998
    Assignees: The Picower Institute for Medical Research, Alteon Inc.
    Inventors: Anthony Cerami, Peter C. Ulrich, Dilip R. Wagle, San-Bao Hwang, Sara Vasan, John J. Egan
  • Patent number: 5766328
    Abstract: There is provided a dental composition for relieving dentin hypersensitivity comprising (A) an aqueous emulsion component which contains, as emulsion particles, polymer particles having a diameter smaller than that of a dentinal tubule and forming an agglomerate larger than the diameter of a dentinal tubule when they react with a calcium compound, and (B) a water-soluble organic acid component or a water-soluble salt component thereof, a calcium salt of the organic acid being insoluble or hardly soluble in water. Using this composition, dentinal tubules open to the surface of dentin are occluded to relieve dentin hypersensitivity immediately and lastingly.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: June 16, 1998
    Assignees: Sun Medical Co., Ltd., Nobuo Nakabayashi
    Inventors: Nobuo Nakabayashi, Takashi Yamamoto, Yasukazu Saimi, Masami Arata, Harumi Tanaka
  • Patent number: 5741773
    Abstract: Stable oral compositions containing an antibacterial casein glycomacropeptide, an anionic surfactant, and a hydrolyzed protein stabilizer, which stabilizes the casein glycomacropeptide in the presence of the anionic surfactant against inactivation without substantially reducing its antibacterial properties.
    Type: Grant
    Filed: April 26, 1996
    Date of Patent: April 21, 1998
    Assignee: Colgate Palmolive Company
    Inventors: Yun Po Zhang, Abdul Gaffar
  • Patent number: 5736158
    Abstract: A composition for the cleaning and protection of partial dentures and the associated natural teeth of the wearer consisting essentially of a peroxy bleach cleanser in an amount of from about 5.0 wt % to about 70.0 wt % of the total weight of the composition; a fluoride source incorporated in a polymer matrix in a polymer/fluoride weight ratio of from about 3:1 to 1:3; at least one surfactant in an amount of from about 3.0 wt % to about 18.0 wt %; an organic peroxy acid bleach in an amount of from about 10.0 wt % to about 40.0 wt %; an active bicarbonate-based effervescent agent in an amount of from about 5.0 wt % to about 65.0 wt %. The composition is formulated as a two-layer compressed tablet wherein one layer contains the peroxyacid bleach cleanser and surfactant while the other layer contains the fluoride and a surfactant.
    Type: Grant
    Filed: March 27, 1996
    Date of Patent: April 7, 1998
    Assignee: The Block Drug Company
    Inventor: Marco Quast
  • Patent number: 5723105
    Abstract: A visually clear gel dentifrice comprising a polishing agent having a refractive index of about 1.41 to 1.47, a substantially water-insoluble noncationic antibacterial agent, an aqueous water-humectant liquid vehicle having a refractive index with about 0.02 refractive index units of the refractive index of the polishing agent and surfactant which is a sulfated polyoxyethylene alcohol sodium or potassium salt or a weight mixture of at least 3:1 to sodium or potassium lauryl sulfate with the sulfated polyoxyethylene alcohol or a weight mixture of about 1:3 to about 3:1 of sodium potassium lauryl sulfate with an N-acyl-N-alkyl taurate sodium or potassium salt. The visually clear systems have reduced formation of surfactant crystals when subject to cool temperature.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: March 3, 1998
    Assignee: Colgate-Palmolive Company
    Inventors: David B. Viscio, Michael Collins, Benjamin Y. Mandanas
  • Patent number: 5711935
    Abstract: The present invention relates to oral hygiene and specifically to an improved method for adding chemotherapeutic agents to dental floss containing several multi-fiber bundles, to methods of treating the oral cavity with the improved dental floss and to the improved dental flosses per se.
    Type: Grant
    Filed: May 10, 1994
    Date of Patent: January 27, 1998
    Assignee: WhiteHill Oral Technologies, Inc.
    Inventors: Ira D. Hill, Michael R. Schweigert
  • Patent number: 5709873
    Abstract: The use of a sulphated saccharide or a salt or a complex thereof as an ingredient in a topical preparation for the prophylaxis or treatment of diseases or conditions of the tooth or tooth-supporting tissue, in particular for the prophylaxis or treatment of inflammatory and plaque-related conditions, a method of preventing or treating such diseases or conditions by topically applying the sulphated saccharide or salt or complex thereof, and a topical preparation containing the sulphated saccharide or salt or complex thereof for the prophylaxis or treatment of such diseases or conditions. The sulphated saccharide is especially a polysulphated or persulphated saccharide, e.g. sucralfate (sucrose octakis(hydrogen sulphate) aluminum complex) or a sodium and/or potassium salt of sucrose octakis(hydrogen sulphate). The preparation may be in the form of a solution, suspension, salve, paste, powder, gel, cream, dental fixative, periodontal implant, chewing gum, chewable tablet, effervescent tablet or lozenge.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 20, 1998
    Assignee: Niels Bukh A/S
    Inventors: Daniel Bar-Shalom, Niels Bukh, Jesper Hamburger
  • Patent number: 5690911
    Abstract: An oral composition comprising in an orally acceptable vehicle, an effective antiplaque amount of an halogenated diphenyl ether or phenolic antibacterial compound, and an amount of an mixed anionic/nonionic surfactant system at weight ratios of about 14:1 to 9:1 which ratios are effective to increase the uptake of the antibacterial compound to dental tissue so as to enhance the therapeutic efficacy of the administered antibacterial compound.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: November 25, 1997
    Assignee: Colgate Palmolive Company
    Inventors: Yelloji Rao K. Mirajkar, John Afflitto, Nuran Nabi, Abdul Gaffar
  • Patent number: 5665332
    Abstract: A system for delivering a chemical agent in the form of a foam, which in its preferred embodiment involves the use of a propellantless dispenser to deliver a formulation containing both an anionic surface active agent such as sodium lauryl sulfate as a foaming agent and hydrogen peroxide as a disinfecting chemical agent.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: September 9, 1997
    Assignee: OralCare Systems, Inc.
    Inventors: David D. Mundschenk, Albert Saferstein, Gary Gerard Fores
  • Patent number: 5656261
    Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a thiazolium compound capable of inhibiting, and to some extent reversing, the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.
    Type: Grant
    Filed: January 18, 1995
    Date of Patent: August 12, 1997
    Assignees: The Picower Institute for Medical Research, Alteon Inc.
    Inventors: Anthony Cerami, Peter C. Ulrich, Dilip R. Wagle, San-Bao Hwang, Sara Vasan, John J. Egan
  • Patent number: 5650156
    Abstract: In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 22, 1997
    Assignee: Vivorx Pharmaceuticals, Inc.
    Inventors: Mark W. Grinstaff, Patrick Soon-Shiong, Michael Wong, Paul A. Sandford, Kenneth S. Suslick, Neil P. Desai
  • Patent number: 5616782
    Abstract: Disclosed are alkyl sulfoacetate compositions comprising a sulfonated ester of the formula:RO(CH.sub.2 CHR.sub.1 O).sub.n COCH.sub.2 SO.sub.3 MwhereR represents straight chain alkyl having from about 6 to 20 carbon atoms;R.sub.1 is hydrogen, methyl, or ethyl;n is 0, or an integer of from 1 to 20; andM represents a cation;the composition being substantially free from monochloroacetate salts and monochloroacetic acid. These compositions are prepared by reacting an alkyl chloroester of the formula RO(CH.sub.2 CHR.sub.1 O).sub.n COCH.sub.2 Cl where R, R.sub.1 and n are as defined above with an excess of sodium sulfite in the presence of a sulfitation catalyst at a temperature of at least about 75.degree. C. Also disclosed are oral care compositions comprising these surfactant compositions.
    Type: Grant
    Filed: November 16, 1995
    Date of Patent: April 1, 1997
    Assignee: Stepan Company
    Inventors: Ralph Thompson, Ned M. Rockwell, Ann M. Michels, William R. Mohring, Kevin C. Kolbe, J. Duke Seibold, James M. Butterwick
  • Patent number: 5587156
    Abstract: Shaving compositions for use in the personal shaving process with a razor blade assembly include insoluble solid particulate additives. The shaving compositions include a mixture of at least one wetting agent, at least one cleansing agent, at least one lather producing composition, and at least one emollient; and further include at least one solid, insoluble particulate additive in a well dispersed suspension throughout said shaving composition. The solid additives are present in an effective amount to produce physical microscopic support for the blade of a razor blade assembly during the personal shaving process. By providing micro-support of the razor blade parallel to skin surface and above surface irregularities, the solid particulate additives provide improved razor blade glide, thereby preventing nicks and cuts, and also enhancing exfoliation of dead skin and removal of grease and oils, as well as improving hair extraction prior to cutting, thereby improving overall smoothness of the post-shaven skin.
    Type: Grant
    Filed: April 18, 1996
    Date of Patent: December 24, 1996
    Assignee: Critical Dimension, Incorporated
    Inventor: Mark S. Wdowik
  • Patent number: 5523091
    Abstract: A cosmetic or pharmaceutical water-in-oil emulsion composition, exhibiting time and temperature stability, comprises in an aqueous phase, (a) a fatty phase comprising (i) a silicone and (ii) a gelling agent and (b) an emulsifying agent. The fatty phase is present in an amount ranging from 15 to 40 weight percent of the emulsion and contains 10 to 90 weight percent of the (i) silicone and 0.1 to 5 percent of the (ii) gelling agent. The emulsifying agent is present in an amount ranging from 0.5 to 10 percent by weight.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: June 4, 1996
    Assignee: L'Oreal
    Inventors: Valerie Pastour, Francoise Pouget, Pierre Fodor
  • Patent number: 5439671
    Abstract: Process for the production of a neutral-tasting paste of an alkyl ether sulfate in glycerol, comprising the steps of:A) forming an aqueous paste of at least one alkyl ether sulfate wherein the aqueous paste contains from about 25 to about 75% by weight of alkyl ether sulfate;B) adding glycerol to the aqueous paste from step A) in from about 1 to about 4 times the quantity by weight of the aqueous paste;C) distilling off substantially all of the water present in the mixture resulting from step B) to produce a substantially ambydrous paste; andD) passing steam heated to a temperature above 100.degree. C. through skid paste with intensive whirling of the paste and steam phases.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: August 8, 1995
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Achim Ansmann, Willi Breitzke, Karl-Heinz Gantke
  • Patent number: RE38330
    Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a thiazolium compound capable of inhibiting, and to some extent reversing, the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: November 25, 2003
    Assignee: Alteon Inc.
    Inventors: Anthony Cerami, Peter C. Ulrich, Dilip R. Wagle, San-Bao Hwang, Sara Vasan, John J. Egan