Abstract: Improved area decontamination products and methods of use thereof are provided which include reactive nanoparticles (e.g., metal oxides, hydroxides and mixtures thereof) with one or more biocides and a liquid carrier for the nanoparticles and biocide(s). The products may be formulated for area decontamination as sprays, fogs, aerosols, pastes, gels, wipes or foams, and the presence of reactive nanoparticles enhances the neutralization of undesirable chemical or biological compounds or agents. The nanoparticles may be from the group consisting of the alkali metal, alkaline earth metal, transition metal, actinide and lanthanide oxides and hydroxides and mixtures thereof. In preferred forms, nanocrystalline oxides and hydroxides of Al, Ca, Ce, Mg, Sr, Sn, Ti and Zn are employed having single crystallite sizes of up to about 20 nm and surface areas of at least about 15 m2/g.

Abstract: The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an oxygen-containing oxidizing agent, such as ozone; a penetrating solvent, such as dimithyl sulfoxide; a dye containing a chelated metal, such as hematoporphyrin; and an aromatic redox compound, such as benzoquinone.

Abstract: A method of treating laminitis in a horse is disclosed, comprising administering to the horse a naturally chelated trace mineral composition; promoting healthy skin, hair and hoof tissue. A method of reducing dietary intake is also disclosed, comprising administering to a horse in need thereof, effective amounts of a naturally chelated trace mineral composition. A method of preparing the chelated trace mineral composition from ocean seabed rock is further disclosed, as well as the chelated trace mineral composition.

Abstract: The invention provides methods and kits to form water swellable gel coatings, preferably lubricious coatings, on substrates, and coated substrates thus formed. The coatings contain one or more antimicrobial metals formed with atomic disorder, together with one or more antimicrobial metals formed with atomic disorder such that the coatings provide an antimicrobial and anti-inflammatory effect when wet. The invention also provides a method to produce metal powders by sputtering a coating onto a moving surface, and then scraping the coating with one or more scrapers to produce the metal powder. The method is particularly useful for producing large amounts of nanocrystalline antimicrobial metal powders formed with atomic disorder, useful in the water swellable gel coatings of this invention.

Abstract: An antifungal composition for the treatment of fungal infections in, around and under human nails, the composition comprising an aqueous solution of a wetting agent such as alcohol and a source of fluoride ions sufficient to establish a pH ranging from about 2.8 to about 3.5 in the composition. A preferred source of fluoride ions is stannous fluoride or stannous fluoride in an amount sufficient to saturate the solution. According to the method of the invention, one or more drops of the subject solution are topically applied to the infected nail and surrounding cuticular area periodically until the infection abates.

Abstract: NGF microencapsulation compositions having controlled release characteristics, preferably with increased stability, for the NGF component, particularly human recombinant NGF (“rhNGF”) are provided that yield enhanced stability of NGF for use in promoting nerve cell growth, repair, survival, differentiation, maturation or function. Methods for making and using such compositions are also provided.

Abstract: A formulation and method to treat and control microbial growth present in the water of climate control systems such as air conditioner air handlers, dehumidifiers, and humidifiers, which formulation can be entrained and dispersed into to living space air. Specifically, a formulation is provided in the form of a tablet or a spray for being applied onto a wetted surface element present in these systems which will effectively control the growth of microbes such as fungus, molds, bacteria, and virus present on the surface for an extended period of time. The formulations include at least two metals, at least two chelating agents, at least one surfactant, and at least one viscosity enhancing compound.

Abstract: Disinfectant formulations are described which are preferably ecologically friendly and non-toxic to mammals and plants, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having at least one metal ion which is microbicidal to at least one microorganism and potassium sodium tartrate in some form. When potassium sodium tartrate is used with these metal ions, it enhances the complex-forming properties of such metal complexes while concurrently increases their efficacy and potency at the same level of metal ion concentrations. These microbicidal formulations can be diluted in suitable proportions into aqueous systems to produce the desired dosages for each individual case, depending on the level and the severity of the contamination. The microbicidal formulations can be applied by conventional methods, e.g., spraying, soaking, fogging, impregnation, and the like.

Abstract: The present disclosure relates to surface covering building materials for roofs, sidewalls and other exterior surfaces exposed tb the weather such as, but not limited to, asphaltic and non-asphaltic roofing materials, wherein said surface covering building materials exhibit long-term resistance to microbial growth-induced staining. The surface covering building materials include a component having antimicrobial potential which consists essentially of (a) a copper component or a tin component and (b) a barium metaborate monohydrate component.

Abstract: The invention relates to a method and composition for destroying or inhibiting proliferation of microbes using oxidative fluorinator compounds. Fluoride salts that do not dissociate completely in aqueous solutions, such as tri- or tetravalent transition metal fluorides, inert gas fluorides, or tri- or tetravalent rare earth fluorides, are effective antimicrobial agents even at levels up to about 20 ppm, when used alone or in conjunction with a strong oxidizer.

Abstract: A method for treating wood, characterized by impregnating wood with a metal-containing treating agent containing lignin and/or lignin derivatives and a metal, a metal compound, and/or a metal ion and oxidizing and/or macromolecularizing of the lignin and/or lignin derivatives in the wood to fix the metal component in the wood, and wood and woody materials obtained by the treating method. According to the method of the present invention, while effectively utilizing lignins, lignosulfonic acids, or lignosulfonic acid salts, leaching of the metal component can be suppressed to a low level to thereby retain the effects due to the incorporation of the metal components for a prolonged period.

Abstract: A drug complex for delivery of a drug or other agent to a target cell, comprising a targeting carrier molecule which is selectively distributed to a specific cell type or tissue containing the specific cell type; a linker which is acted upon by a molecule which is present at an effective concentration in the environs of the specific cell type; and a drug or an agent to be delivered to the specific cell type. In particular, a drug complex for delivering a cytotoxic drug to prostate cancer cells, comprising a targeting carrier molecule which is selectively delivered to prostate tissue, bone or both; a peptide which is a substrate for prostate specific antigen; and a cytotoxic drug which is toxic to androgen independent prostate cancer cells.

Abstract: A method of arresting the flow of blood and other protein containing body fluids flowing from an open wound and for promoting wound healing. In the method, a substantially anhydrous compound of a salt ferrate is provided for a unique use which, when hydrated after mixing with a victim's own blood or other aqueous media, produces Fe+++ thereby promoting clotting when applied in a paste form to the wound for a time sufficient to arrest substantial further blood and other body fluid flow from the wound. The compound is formed of a ferrate (VI) salt taken from the group consisting of H, Li, Na, K, Rb, Cs and Fr. However, to decrease or eliminate stinging sensation, the compound may be formed having a ferrate (VI) salt taken from the group consisting of Be, Mg, Ca, Sr, Ba, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, TI, Pb, Bi, Al, As, NH4 and N(C4H9)4.

Abstract: The present invention provides an antimicrobial agent consisting of glass which comprises 50 to 60 mole % of ZnO, 20 to 30 mole % of at least one member selected from the group consisting of B2O3 and P2O5, 1 to 10 mole % of at least one member selected from the group consisting of Al2O3 and ZrO2, 5 to 10 mole % of an alkali metal oxide and 0 to 15 mole % of SiO2 and an antimicrobial agent consisting of glass which comprises 50 to 70 mole % of ZnO, 20 to 35 mole % of P2O5, 0.5 to 10 mole % of Al2O3, 0.5 to 10 mole % of SnO2, 0 to 5 mole % of SiO2 and 5 to 10 mole % of an alkali metal oxide as well as an antimicrobial resin composition and antimicrobial artificial marble, each of which comprises a resin and the antimicrobial agent blended therewith. The antimicrobial resin composition and the antimicrobial artificial marble are excellent in their antimicrobial properties, resistance to color change and water resistance.

Abstract: Compositions and methods are provided for inhibiting skin irritations attributable to chemical irritants or environmental conditions by the application of anti-irritant amounts of aqueous soluble divalent tin cation.

Abstract: An antifungal composition for the treatment of fungal infections in, around and under human nails, the composition comprising an aqueous solution of a wetting agent such as alcohol and a source of fluoride ions sufficient to establish a pH ranging from about 2.8 to about 3.5 in the composition. A preferred source of fluoride ions is stannous fluoride or stannous fluoride in an amount sufficient to saturate the solution. According to the method of the invention, one or more drops of the subject solution are topically applied to the infected nail and surrounding cuticular area periodically until the infection abates.

Abstract: A biocidal composition composed of a ternary complex of a negatively-charged biocide, a transition metal ion and chelator has synergistic biocidal effects as compared with a composition of each of the components alone. The chelator is preferably a neutral or positively-charged chelator. The ternary complex may be used for killing or inhibiting the growth of living cells.

Abstract: The present invention relates to a method for protecting a human patient or a mammalian animal to be subjected to chemotherapy treatment of a tumor not residing in the scalp of the patient or the skin of the animal against chemotherapy-induced alopecia, comprising administering to the scalp of the patient or the skin of the animal an effective amount of a composition comprising a chemical inducer of the stress protein response sufficiently prior to the administration of a chemotherapeutic drug. It also relates to pharmaceutical compositions for the prevention of chemotherapy-induced alopecia. It further relates to a method for protecting a human patient or a mammalian animal to be subjected to chemotherapy treatment of a tumor not residing in the scalp of the patient or the skin of the animal against chemotherapy-induced alopecia, comprising administering to the scalp of the patient or the skin of the animal an effective heat dose sufficiently prior to the administration of a chemotherapeutic drug.

Abstract: Mammalian hair growth is reduced by applying to the skin an inhibitor of alkaline phosphatase other than cromoglycate or a salt thereof.

Abstract: The present invention relates to compositions and methods of induction of a cellular stress response and a protected phenotype using heavy metal ions. The invention relates to methods of protecting a mammal against injury caused by a noxious condition by administering to the mammal a heavy metal in sufficient quantity and under appropriate conditions to induce a sufficient cellular stress response to provide protection (partial or complete) against injury caused by a noxious condition. The invention also relates to methods of inducing a cellular stress response in a mammal by administering a heavy metal in sufficient quantity and under appropriate conditions to induce a cellular stress response to protect the mammal against injury caused by a noxious condition.

Abstract: The invention relates to an oral care composition with antiplaque agents. The antiplaque agents are complexes of divalent copper, zinc, iron or tin, or trivalent iron with a specific class of cyclic &agr;-hydroxyketones. A typical example is the copper (II)-ethylmaltol complex. These complexes are more active antiplaque agents that e.g. copper-hinokitiol complexes.

Abstract: Tissue and organ repair, healing and augmentation are enhanced by administering pharmaceutically acceptable group IIIa element-containing compounds in amounts sufficient to provide therapeutic levels of the elements. Group IIIa element-containing compounds mimic the beneficial biological effects of endogenous growth factors to induce cells responsible for repair, healing and augmentation of tissues and organs. Group IIIa element-containing compounds are suitable for a variety of applications such as wound healing, bone fracture repair, treatment of dermatologic conditions and successful bonding of implanted tissue grafts and prostheses.

Abstract: The invention provides methods for producing edible plant tissue biomasses suitable for use as nutritional supplements. The seedlings are exposed to at least one metal and normal seedling growth is interrupted prior to the eleventh day following germination to thereby produce a metal-enriched plant seedling tissue biomass. The metal-containing edible plant tissue biomasses are also provided.

Abstract: Medicinal compositions for the topical treatment of skin diseases or conditions which contain a combination of a zinc compound and tin compound in an inert carrier, liquid or solid. Optionally, the composition can include a small amount of a selenium compound as a part of the active ingredient combination.

Abstract: Microbicidal formulations are described which are preferably ecologically friendly and non-toxic to mammals, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having the formula R-M, wherein R is at least one organic chelating moiety and M is at least one metal ion which is microbicidal to at least one microorganism. These complexes can disrupt microorganism activities by penetrating the natural protecting bio-films of such microorganisms through the reaction of the R-group with the organic constituents of these microorganisms while releasing M into their intra-cellular media. Thus, this process exhibits its biocidal activities from the inside-out, contrary to other methods which rely on damaging the protective biofilms.

Abstract: An active water is disclosed, comprising water having a substance containing a divalent and trivalent iron salt component and an organogermanium compound and/or a seawater concentrated solution contained therein, the active water of the invention possessing superior functions including pharmacological and physiological functions and being effective for the medicinal use.

Abstract: This invention relates to the use of gallium-containing compounds, to inhibit intracellular pathogens including pathogens that are members of the genus Mycobacteria, Legionella, Histoplasma, and Leishmania and to organisms causing chronic pulmonary infection such P. aeruginosa.

Abstract: Tissue and organ repair, healing and augmentation are enhanced by administering pharmaceutically acceptable group IIIa element-containing compounds in amounts sufficient to provide therapeutic levels of the elements. Group IIIa element-containing compounds mimic the beneficial biological effects of endogenous growth factors to induce cells responsible for repair, healing and augmentation of tissues and organs. Group IIIa element-containing compounds are suitable for a variety of applications such as wound healing, bone fracture repair, treatment of dermatologic conditions and successful bonding of implanted tissue grafts and prostheses.

Abstract: A single phase aqueous gel composition comprising 0.0-50% of a polysaccharide gellant, and 1-30% of an antiperspirant active ingredient solubilized in the aqueous single phase.A water and oil emulsion comprising a gelled aqueous phase comprising a polysaccharide gellant and an antiperspirant active ingredient solubilized in the aqueous single phase; and an oil phase,A method for preparing an emulsion antiperspirant or deodorant composition comprising preparing a first aqueous solution of antiperspirant or deodorant active, preparing a second aqueous solution of polysaccharide gellant, emulsifying the second aqueous solution in an oily phase to form an emulsion, combining the first aqueous solution and the emulsion so that the first and second aqueous solutions form a single homogeneous phase in the emulsion; and pouring the mixture into containers.

Abstract: The present invention relates to heavy metal chelate compositions, which are used as fungicides and bactericides, and methods of using the compositions. In particular, the present invention relates to a chelate, that is an EDDHA (copper-ethylenediamine-di-o-hydroxyphenylacetic acid), combined with a heavy metal, including iron, tin, zinc, manganese, copper, and combinations thereof.

Abstract: The invention relates to an organometallic complex obtainable by reaction:of a cation of a metal (M) in an oxidation state at least equal to 2 useful as a biocatalyst in living metabolism,of a mixture of sitosterol and sitostanol, or of pure sitostanol or of a plant extract containing same,of the diglyceride of formula (I): ##STR1## in which: R.sub.1 is an acyl residue of oleic acid (C.sub.18 :1),R2 in an acyl residue of a linear or branched, saturated or unsaturated fatty acid having between 2 and 18 carbon atoms. More particularly, the invention relates to complexes in which R.sub.2 is an oleoyl or acetyl group. The invention also relates to pharmaceutical compositions containing this complex, particularly those wherein the metal is vanadium, and to their use in the treatment and/or the prevention of hypercholesterolaemia and/or of hypertriglyceridaemia, of insulin-dependent or non insulin-dependent diabetes, of insulin resistance and associated pathologies.

Abstract: A process of making a mineral powder usable for manufacturing functional fiber includes pulverizing mineral ingredients including germanium of 60 weight percent, biostrome of 20 weight percent, jade of 10 weight percent, anorthite of 5 weight percent and minerals of 5 weight percent to about 100 mesh and charging the mineral ingredients into an internal furnace of copper having a wall thickness of 2-5 mm; placing feldspar pulverized to about 325 mesh between an inner surface of an electric heating plate and an outer surface of the internal furnace; heating the mineral ingredients and feldspar for seven days at about 1000.degree. C. by means of the electric heating plate; pulverizing the mineral ingredients having had thermal deformation from the internal furnace again to more than about 325 mesh; placing the pulverized mineral ingredients into the internal furnace again; charging the internal furnace with the burnt feldspar; again heating the mineral ingredients for three days at 1000.degree. C.

Abstract: The present invention provides antibacterial zeolite exhibiting a less discoloring action, obtained by treating the surface of zeolite supporting an antibacterial metal with 0.5 to 20% by weight, based on said zeolite, of a composition comprising (A) 100 parts by weight of a hydrolyzable silane and/or oligomer thereof which comprises 10 to 100% by weight of a hydrolyzable silane and/or oligomer thereof having an aryl group; (B) 1 to 1000 parts by weight of an organopolysiloxane having a basic nitrogen atom; and (C) 0.2 to 250 parts by weight of an acid which is soluble in water and which can form a salt with the aforesaid (B). The present antibacterial zeolite exhibits a remarkably less action of discoloring an organic polymer which contains the antibacterial zeolite when the polymer blend is placed under the influence of heat or the sunshine.

Abstract: Mammalian hair growth is reduced by applying to the skin an inhibitor of alkaline phosphatase.

Abstract: A method of administering a Generally Accepted As Safe (GRAS) indium compound, preferably indium sulfate mixed with distilled water, comprises preferably spraying 1 to 27 mg of indium sulfate into the mouth on arising in the morning and without eating or drinking for at least 10 minutes thereafter.

Abstract: This invention relates to methods for using gallium-containing compounds to inhibit the growth of pathogenic P. aeruginosa in a mammal infected with the pathogen.

Abstract: The present invention relates to compositions and methods of production of stress proteins using tin or zinc metal ions. The invention relates to methods of protecting a mammal against injury caused by a noxious condition by administering to the mammal tin or zinc metal ions in sufficient quantity and under appropriate conditions to induce production of stress proteins at sufficient levels to provide partial or complete protection against injury caused by a noxious condition which occurs subsequent to stress protein production. The invention also relates to methods of inducing stress protein production in a mammal by administering tin or zinc metal ions in sufficient quantity and under appropriate conditions to induce production of stress proteins to protect the mammal against injury caused by a noxious condition.

Abstract: This invention provides a novel fungicide composition which has a bicarbonate-containing inorganic salt ingredient which enhances the efficacy of a fungicide ingredient for the treatment of cultivated crops. An invention fungicide composition also contains a surfactant ingredient, and a water-soluble organic compound which functions as a compatibility enhancing ingredient in aqueous formulations, and the ingredients improve the spreadability and adhesiveness of the composition when applied to foliage. An invention fungicide composition also contains a fertilizer-effective ratio of nitrogen, phosphorus and potassium.

Abstract: The present invention relates to multi-purpose mineral powder emitting the large quantities of far infrared rays, negative ion and oxygen heat having ingredients of germanium of 20 weight percent, clinochlore of 10 weight percent, jade of 10 weight percent, zeolite of 10 weight percent and halite of 50 weight percent, and its process, in which the above five ingredients are pulverized to about 300 mesh; are placed into an inner surface having silver leaf (Ag) of an internal furnace made of chondrodite; are heated through a heating plate for nine days at about 1000.degree. C. so as to have thermal deformation after placing chondrodite pulverized to about 200 mesh between the inner surface of the electric heating plate and the outer surface of the internal furnace; and are then pulverized to about 325 mesh.

Abstract: This invention relates to preservative compositions which comprise a biocidal metal compound and an fungicidal compound containing a triazole group. Methods of treating wood with the composition are also described.

Abstract: A method and treatment is described for treating epidermal irritations due to insect bites and parasitic manifestations by applying a non-toxic composition of the chemical compound stannous fluoride.

Abstract: Cosmetic/dermatological/pharmaceutical compositions, well suited for the treatment of a variety of mammalian disorders of, for example, the skin, hair and/or mucous membranes, a manifestation of which is an excess in the synthesis and/or in the release of substance P, e.g., for the treatment of cutaneous disorders and sensitive skin, comprise an effective substance P antagonist amount of at least one salt of yttrium, lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, tin, manganese, or mixture thereof, in a cosmetically/pharmaceutically acceptable medium therefor.

Abstract: A method for reducing the desire of a person to smoke tobacco includes orally administering to the person an aqueous solution containing a polyvalent cation derived from a metal selected from the group consisting of palladium, copper, zinc, aluminum, tin, and bismuth. The method includes smoking tobacco by the person to whom the solution is administered, subsequent to the oral administration of the solution.

Abstract: Dermatological/pharmaceutical compositions, well suited for the therapeutic treatment of and/or alleviation of pain associated with at least one of the skin disorders, zona, poszoster, scald or burns, demodicidosis, skin ulcer, fibrosis, hypertrophic cicatrization and/or acne rosacea, comprise an effective substance P antagonist amount of at least one salt of yttrium, lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, tin, zinc, manganese, cobalt, barium, strontium, or mixture thereof, in a dermatologically/pharmaceutically acceptable medium therefor.

Abstract: Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying diphenyldiones. These compounds may be directly incorporated into the marine structure during manufacture, directly applied to the structure, or applied to the structure by means of a coating.

Abstract: A topically applied shaving composition for use by a human subject suffering from or prone to development of pseudofolliculitis barbae is disclosed. The composition comprises as its active ingredient about 0.01-5% by weight of a bacteriostatic/hemostyptic agent, and an aqueous or water-miscible solvent, a volatile silicone and a thickening agent. A method of removing hair from a hairy skin area of such a subject comprising the application of a topical shaving composition containing about 0.01-5% by weight of a bacteriostatic/hemostyptic agent prior to removal of the hair by shaving, tweezing or waxing, is also disclosed.

Abstract: The invention relates to the use of a salt of an alkaline-earth metal in a cosmetic, pharmaceutical, veterinary and/or dermatological composition for treating, in particular, sensitive skins. It relates, in addition, to the use of a salt of an alkaline-earth metal for preventing and/or combating rosacea and/or skin irritation and/or dartre and/or pudic erythema and/or dysesthetic sensation and/or sensation of inflammation and/or pruritus of the skin and/or of the mucous membranes. The salt is in particular strontium nitrate or chloride.

Abstract: The invention relates to the use of stannous compounds to combat bad breath. Preferably, the stannous compound is used together with a zinc compound. A preferred stannous compound is stannous pyrophosphate, and a preferred zinc compound is zinc citrate. The compounds are preferably included in an oral care composition such as a dentifrice or a mouth wash.

Abstract: Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying onto or into the marine structure a phenylamide compound. These compounds may be directly incorporated into the marine structure during manufacture, directly applied to the structure, or applied to the structure by means of a coating.

Abstract: The present invention relates to the use of at least one extract from at least one non-photosynthetic filamentous bacterium as substance P antagonist in a cosmetic composition or for the preparation of a pharmaceutical composition. The invention also relates to the use of at least one extract from at least one non-photosynthetic filamentous bacterium in a cosmetic composition or for the preparation of a pharmaceutical composition intended for the treatment of disorders associated with an excess in the synthesis and/or in the release of substance P. The invention additionally relates to various compositions containing an extract from at least one non-photosynthetic filamentous bacterium and to a cosmetic treatment process.