Abstract: Vitamin B12 is used to stimulate heme oxygenase production. In turn, levels of the molecules 12(R)-HETE and 12(R)-DIHETE, which are arachidonic acid derivatives, are reduced. Various topical formulations containing vitamin B12, but no other vitamins, are described.

Abstract: The present invention provides a method for blocking a cellular proton pump that comprises contacting a cell with a cellular proton pump-blocking effective quantity of In-EDTA or Tl-EDTA. The present invention also provides a method of treating or preventing cell-mediated disorders in a vertebrate animal by administering In-EDTA or Tl-EDTA to the vertebrate animal, as well as a method for stopping the cellular proton pump-blocking effect of Group IIIa metals such as Ga, In, and Tl, through use of suitable chelating agents. Suitable compositions for use in the aforementioned methods are provided as well.

Abstract: Disclosed are methods for treatment of herpes virus infections in a human or lower animal subject comprising administering to the subject stannous salt and one or more pharmaceutically acceptable carriers suitable for topical administration. The stannous salt may be one or more stannous carboxylates, a stannous halide selected from the groups consisting of stannous bromide, stannous iodide, and stannous chloride dihydrate, two or more stannous halides, or one or more stannous halides and one or more stannous carboxylates. Another therapeutic agent, such as an anesthetic, analgesic, or antibiotic, may also be administered. Also disclosed are compositions effective in treating herpes virus infections in a human or lower animal subject comprising stannous fluoride, one or more therapeutic agents, and one or more pharmaceutically acceptable carriers suitable for topical administration.

Abstract: Disclosed are methods for treatment of herpes virus infections in a human or lower animal subject comprising administering to the subject stannous salt and one or more pharmaceutically acceptable carriers suitable for topical administration. The stannous salt may be one or more stannous carboxylates, a stannous halide selected from the groups consisting of stannous bromide, stannous iodide, and stannous chloride dihydrate, two or more stannous halides, or one or more stannous halides and one or more stannous carboxylates. Another therapeutic agent, such as an anesthetic, analgesic, or antibiotic, may also be administered. Also disclosed are compositions effective in treating herpes virus infections in a human or lower animal subject comprising stannous fluoride, one or more therapeutic agents, and one or more pharmaceutically acceptable carriers suitable for topical administration.

Abstract: There are disclosed stabilized Ti-Sn-O nanoclusters formed by complexing Ti-Sn-O nanoclusters with a salt of an alpha-hydroxy acid and also complexed nanoclusters with increased charge transfer interaction formed by annealing the complexed nanoclusters. Also disclosed are compositions for protection against ultraviolet radiation in which the nanoclusters are utilized with the usual topical carriers in an amount to give the level of sun protection factor (SPF) desired. Further disclosed is the method of making the nanoclusters involving acid hydrolyzing a titanium alkoxide and then reacting the hydrolyzed alkoxide with a tin halide.

Abstract: A batch process for increasing the calcium content of a water solution comprises the placement of a tin catalyst, a glass fibrous material, and water into a sealed tank and the application of heat to the tank for predetermined time intervals at progressively decreasing temperatures. The resulting solution is then extracted from the tank, wherein the solution has between 200 ppm and 500 ppm concentration of calcium.

Abstract: A method of treating pulmonary inflammation in mammals, comprising administering an effective amount of a pharmaceutically acceptable gallium compound and wherein said gallium is elected from the group consisting of gallium nitrate, gallium citrate, gallium chloride, gallium carbonate, gallium acetate, gallium tartrate, gallium oxalate, gallium oxide, gallium arsenide and hydrated gallium oxide.

Abstract: An oral hygiene composition comprises an effective amount of an antimicrobial agent in the form of a particulate non-ion-exchanging support material combined with a metal source providing antimicrobial metal ions in use. Preferably the antimicrobial agent is particulate titanium dioxide coated with silver chloride.

Abstract: Tissue and organ repair, healing and augmentation are enhanced by administering pharmaceutically acceptable group IIIa element-containing compounds in amounts sufficient to provide therapeutic levels of the elements. Group IIIa element-containing compounds mimic the beneficial biological effects of endogenous growth factors to induce cells responsible for repair, healing and augmentation of tissues and organs. Group IIIa element-containing compounds are suitable for a variety of applications such as wound healing, bone fracture repair, treatment of dermatologic conditions and successful bonding of implanted tissue grafts and prostheses.

Abstract: Vitamin B12 is used to stimulate heme oxygenase production. In turn, levels of the molecules 12(R)-HETE and 12(R)-DIHETE, which are arachidonic acid derivatives, are reduced. Various topical formulations containing vitamin B12, but no other vitamins, are described.

Abstract: There are provided compositions for, and a method of, treating malignancies which comprise effective amounts of a novel combined therapy comprising a platinum compound and a tellurium or selenium compound, e.g., ammonium trichloro (dioxoethylene-O,O-tellurate), and administering the respective compounds simultaneously or separately.

Abstract: A method of treating endotoxic shock in mammals, comprising administering an effective amount of a pharmaceutically acceptable gallium compound. A preferred gallium compound is gallium nitrate.

Abstract: An antibacterial ceramic contains an antibacterial material produced by loading an antibacterial metal such as silver on a calcium ceramic carrier and an inorganic material such as cordierite, and has a bulk density of 0.6-1.2 g/cm.sup.3. An antibacterial ceramic filter contains an antibacterial material produced by loading an antibacterial metal such as silver on a calcium ceramic carrier, an aggregate such as mullite, and a binder such as frit, and has a porosity of 20% or more. The light-weight antibacterial ceramic is suitably applicable to a roof garden or the like. The antibacterial ceramic filter can remove and extirpate various bacteria and suspensions.

Abstract: A method of treating or preventing babesiosis is described which is based on the administration of a tellurium compound. The preferred tellurium compound is ammonium trichloro (O,O'-dioxoethylene tellurate).

Abstract: An apparatus and process for administering minerals to the human body by mixing pre-selected particulated minerals with graphite and coal tar to form a bar (10a), vaporizing the bar (10a) to form a mineral rich vapor, and directing the vapor to a patient's skin using an enclosure (30).

Abstract: Skin, connective and support tissue repair is enhanced and augmented by administering pharmaceutically acceptable gallium-containing compounds in amounts sufficient to provide therapeutic levels of elemental gallium. Gallium-containing compounds mimic the effects of endogenous growth factors to induce cells within these tissues to produce new matrix by increasing the formation of critical structural matrix proteins responsible for skin, support and connective tissue repair, maintenance and augmentation. Gallium-containing compounds are suitable for a variety of applications in wound healing, including dermatologic and cosmetic skin repair, bone fracture repair and successful bonding of implanted tissue grafts and connective and support tissue prostheses.

Abstract: Tungstoniobate compounds containing an ion of general formulaA.sub.x W.sub.y Nb.sub.a O.sub.b !.sup.p- Iwhere A=P, Si, Ge, x=0 or an integer from 1 to 10, y is an integer from 1 to 10, y is an integer from 1 to 40, a is an integer from 1 to 8, b is an integer from 15 to 150, and p is an integer dependent upon the nature and oxidation state of element A, have been found to be active against viruses including especially HIV and Herpes Simplex. Pharmaceutical compositions and methods of treatment are disclosed.

Abstract: This invention provides a novel fungicide composition which has bicarbonate-containing inorganic salt ingredients which enhance the efficacy of a fungicide ingredient for the treatment of cultivated crops. The fungicide composition contains nitrogen, phosphorus and potassium fertilizer elements, and the inorganic salt ingredients contain at least two different alkali metal or ammonium cations.

Abstract: This invention provides a co-micronized bicarbonate salt composition which is a blend of ingredients having a particle size between about 0.01-1.0 micron. The composition is produced by mill co-micronization of a crystalline bicarbonate ingredient and a crystalline inorganic compound ingredient having a Mohs hardness value between about 3-7. A co-micronized blend such as sodium bicarbonate and zinc oxide is free-flowing and essentially free of agglomerated particles.

Abstract: This invention describes an electromagnetic wave-absorbing surface modified magnetic particle for use in medical applications. The magnetic particles are coated with an amphipathic organic compound and an amphipathic vesicle forming lipid. These particles may be used in a method of treatment of cancer, as well as for the treatment of infectious disease. For cancer treatment the invention comprises providing a patient said coated particles, absorbing the coated particle intracellularly into the cancer cell, and subjecting the patient to an alternating electromagnetic field to inductively heat the magnetic core particle along with the cancer cells. The inductive heating of the magnetic core particle is then continued so as to achieve an increase in intracellular temperature which selectively kills the cancer cells.

Abstract: This invention provides a co-micronized bicarbonate salt composition which is a blend of ingredients having a particle size between about 0.01-1.0 micron. The composition is produced by mill co-micronization of a crystalline bicarbonate ingredient and a crystalline inorganic compound ingredient having a Mohs hardness value between about 3-7. A co-micronized blend such as sodium bicarbonate and zinc oxide is free-flowing and essentially free of agglomerated particles.

Abstract: The invention provides a novel antibacterial compound and a process for producing it. Futhermore, the invention provides a novel antibacterial polymer composite comprising a polymer and the antimicrobial compositon.

Abstract: A method of preventing or treating hypoxia-associated ocular complications in a host in need of such prevention or treatment which comprises administering to the eye of the host a prophylactically or therapeutically effective amount of at least two agents selected from the group consisting of a heme oxygenase inducer, a membrane-permeable anti-acidosis buffer, and an osmoprotectant, as well as an aqueous ophthalmic composition useful therefor.

Abstract: A liposome composition which comprises a substantially uniform sized inorganic core coated with an amphipathic organic compound and further coated with a second amphipathic vesicle forming lipid. Also disclosed are novel phenyl lipid compounds which serve as the amphipathic vesicle forming lipid and methods are described for delivering a drug for slow release into the blood stream, and for targeting a selected tissue or cells with the inorganic core liposome compositions.

Abstract: An organic germanium compound to be effectively used for curing AIDS or making AIDS asymtomatic in various forms is expressed by the following rational formula: ##STR1## wherein n is an integer of 1 or 2 or more, is in the form of a white acicular or needle crystal, shows a solubility of 1.570/100 ml in water at 25.degree. C. and exhibits a melting (decomposition) point of 240.degree. C.

Abstract: The present invention relates to a dentifrice composition comprising a stannous compound that releases stannous ions in the composition such as stannous fluoride or stannous pyrophosphate. These stannous ions can be converted in the composition into the inactive stannic ions, and to prevent such conversion according to the present invention an antioxidant is incorporated into the composition, such as butylated hydroxyanisole, butylated hydroxytoluene and ethyl vanillin.

Abstract: Methods, for the treatment of humans and lower animal subjects having a gastrointestinal disorder, comprising administering bismuth and administering an antimicrobial. From about 50 to about 5000 milligrams of bismuth are administered, per day, for from 3 to 56 days. A safe and effective amount of antimicrobial is administered for from 1 to 21 days. Preferred processes also include a step for performing a diagnostic test on the subject for detection of a campylobacter-like organism infection of the subject. The invention also provides compositions containing a safe and effective amount of bismuth and a safe and effective amount of antimicrobial.

Abstract: The present invention provides a novel antimicrobial composition and a process for preparing the composition which composition is useful as antimicrobial and/or bactericidal material. The antimicrobial composition of the invention comprises silica gel and an antimicrobial coat of aluminosilicate on the surface of the silica gel, said composition having a pore volume of at least 0.3 cm.sup.3 /g and a specific surface area of at least 100 m.sup.2 /g. The aluminosilicate coat consists of either partial or complete substitution of ion-exchangeable metal ion (M) in aluminosilicate solid particles represented by the formulaxM.sub.2/n O.Al.sub.2 O.sub.3.ySiO.sub.2.zH.sub.2 O,wherein x and y represent the numbers of molecules of the metal oxide and silicon dioxide, respectively, M is an ion-exchangeable metal, n is the atomic valence of M, and z is the number of molecules of water.

Abstract: Gallium compounds are utilized to treat or inhibit arthritis.

Abstract: The invention concerns new diorganotin compounds derived from N-cyclohexyl-N'-hydroxy diazenium oxide, as well as bactericides and fungicides which are suitable as disinfectants, as preservatives for wood and other materials, for bactericidal and fungicidal finishing of textiles, plastics, building materials or as biocides for paint systems and which contain these diorganotin compounds as active ingredients.

Abstract: The present invention provides a method for the stimulation of the production of lymphokines which comprises the administration of an effective amount of a tellurium tetrahalide.

Abstract: The invention relates to a method for treating or preventing ocular swelling and corneal-conjunctival inflammation. This is accomplished by administering to the eye of a subject, either before or after exposure to an ocular swelling stimulus, an amount of a heme oxygenase inducing agent sufficient to increase levels of heme oxygenase in the eye and thereby to reduce or to regulate the amount of 12(R) hydroxyeicosatetraenoic and 12(R) DiHETE acids present. Particularly preferred agents include stannous compounds, such as SnCl.sub.2, other metals, heme derivatives and Vitamin B12. These compounds may be administered in various forms.

Abstract: A method and composition for treating diseases having a viral etiology is provided. The method comprises administering either locally or systemically an antiviral effective, non-toxic amount of stannous fluoride. An isotonic, sterile injectable preparation of stannous fluoride for systemic administration is also disclosed.

Abstract: Compounds of the formula,A.sub.x [D'(MW.sub.11 O.sub.39).sub.2 ].multidot.yH.sub.2 Oin which A is a cation, x is an integer, M is B, Si or P, D is metal and D' is a lanthanide in oxidation state 3 or 4, L is a neutral or anionic ligand, and y is an interger, have anti-viral activity in a standard screen, and may be used to produce compositions and also coated articles and devices for treatment or prophylactic treatment of patients at risk.

Abstract: Certain tellurium compounds have been found to have the ability to stimulate the in vivo and in vitro production of cytokines and thier receptors. These compounds may be utilized in the treatment of autoimmune diseases, immune diseases and infectious diseases.

Abstract: A pharmaceutical preparation for oral or transdermal treatment of wounds, damaged tissue and inflammation which is a solution containing water and metallic trace elements or salts thereof in a physiological quantity.

Abstract: The mineral composition is useful for treatment of blood acidosis, peritoneal ascites and anemia. It is a combination of particulate wood ash and calcium carbonate.

Abstract: An organogermanium compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen atom, alkyl, substituted alkyl, phenyl or substituted phenyl, and R.sub.5 is a radical of ##STR2## n is an integer of 2 or more, and R.sub.6 and R.sub.7 are hydrogen atom, alkyl, substituted alkyl, phenyl or substituted phenyl,a salt of the compound, a processs for the preparation of the compound as well as a use of the compound as an affective ingredient for pharmaceutical preparations.

Abstract: A substance with therapeutic applications comprises, in aqueous solution:(1) at least one organo-silicon compound having either of the following formulas: ##STR1## in which: n is an integer between 1 and 1000, and preferably between 1 and 50;p, q, r are integers between 0 and 1000, and preferably between 0 and 60;R and R' represent, independently of one another, a linear aliphatic group, branched or cyclic, saturated or not, hetero-linear branched or not, cyclic saturated or not, aromatic, heteroaromatic, arylaliphatic, or heteroarylaliphatic, which may also be functional, whilst R may also be OH, OR or OSiR.sub.3 ;.SIGMA. is R, H or SiR.sub.3, where R is as previously defined;.SIGMA.' is R and more particularly CH.sub.3, OR, OH or OSiR.sub.

Abstract: The present invention provides salts of organogermanium compounds expressed by the following Formual (a): ##STR1## (wherein M denotes an oxygen or sulfur atom; and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 may be the same or different from each other and each denotes a hydrogen atom, a lower alkyl group, or an aryl group) with compounds having basic groups, and medicines containing the salts such as biological response modifiers and antitumor agents.

Abstract: According to the invention, a liquid deliquescent composition is substantially uniformly applied to grain, animal feed, animal feed ingredients, hay or poultry litter product, inhibiting moisture migration or translocation in the product and thereby inhibiting the formation of mold-generating accumulations of moisture adjacent the walls of storage containers for grain, animal feed, feed ingredients or hay which are subject to large overnight temperature drops, and similary inhibiting the formation of mold-generating accumulations of moisture adjacent the walls of grain elevators or silos subject to large seasonal temperature drops. Such inhibiting of moisture migration or translocation according to the invention also inhibits the formation of dry zones in grain, animal feed, feed ingredients, hay or poultry litter, thereby inhibiting the generation of dust from such products, including the inhibiting of dust generation during the screw-conveying of grain to storage.

Abstract: Stannous fluoride containing aqueous, non-abrasive home treatment gel compositions including an alkyl vinyl ether and maleic anhydride or acid copolymer as a stabilizing agent for stannous fluoride and methods for preparing such stabilized compositions.

Abstract: A mold and dust inhibiting composition which has particular utility in connection with the storage and handling of animal feeds, grains, and hay, and also in connection with the use of animal litter such as poultry litter, as well as having general utility for controlling both mold and dust. The composition of the invention is an aqueous solution of one or more salts of propionic acid, one or more deliquescent substances, and also preferably one or more humectants. Propionate ions are made available for mold control by this solution just as effectively as propionic acid, but without the disadvantages of propionic acid including a bad odor, serious corrosive characteristics, and high volatility and hence short residual time. The deliquescent, and preferably also the humectant, prevent moisture from migrating toward container walls where there is a large day/night temperature differential, and also prevent dry regions from developing and producing potentially harmful dust.