Abstract: An improved peritoneal dialysis solution comprising an osmotic agent having at least one amino acid, and a method of administering same to a patient are provided. Pursuant to the present invention, the sodium concentration in the solution is decreased thus causing sodium to be transported from the circulation to the peritoneal cavity. This provides for an improved ultrafiltration profile that is, more volume over a longer period of time, for the same initial osmolality when compared to standard solutions. Also, the same ultrafiltration profile as standard solutions can be achieved with lower initial osmolalities.

Abstract: The invention relates to a pharmaceutical composition for treating the symptoms of vulvitis and vulvovaginitis which comprises folic acid, panthenol and/or allantoin, protein hydrolysate or casein hydrolysate, lactose or dextrose, lactic acid, magnesium sulfate and sodium chloride or ammonium chloride in the form of suppositories, ointments, solutions or sprays and a method of use thereof.

Abstract: A peritoneal dialysis solution and method of administering same to a patient are provided wherein the sodium concentration in the solution is decreased thus causing sodium to be transported from the circulation to the peritoneal cavity. This provides for an improved ultrafiltration profile (more volume over a longer period of time) for the same initial osmolality when compared to standard solutions. Also, the same ultrafiltration profile as standard solutions can be achieved with lower initial osmolalities. A reduced amount of osmotic agent can be used to achieve equivalent ultrafiltration.

Abstract: A granular to fine-granular dry mix powder (an artificial kidney perfusion component A of uniform composition) for use in the preparation of an artificial kidney perfusion fluid for bicarbonate dialysis and a method of producing the same.A granular to fine-granular Composition A comprising granules each comprised of a plurality of NaCl grains carrying KCl, CaCl.sub.2, MgCl.sub.2 and sodium acetate adhered to the surface of each grain.NaCl, KCl CaCl.sub.2, MgCl.sub.2 and sodium acetate are mixed in the presence of not less than 10 weight parts of water based on 100 weight parts of sodium acetate and the resultant mixture is heated at not less than 50.degree. C. to bring the sodium acetate into a transiently molten state and mixing acetic acid with the same mixture.

Abstract: The present invention provides compositions in the form of solutions, tablets and gels adapted for prophylaxis and treatment of oral lesions. The compositions are suitable for use as an oral lavage, and comprises water, a peroxide (preferably hydrogen peroxide) in a premixed aqueous form in the preparation mixture, with between about 0.01% and about 0.4% of a bicarbonate (preferably sodium bicarbonate). To produce such a composition adapted for the prophylaxis and treatment of oral lesions most preferably involves dissolving the peroxide and bicarbonate in an aqueous solution to produce a premixed preparation. Additionally, a method for prophylaxis and treatment of oral lesions incident the use of chemotherapeutic agents is included in the present invention.

Abstract: The invention relates to an antemortem stress supplement for livestock containing one or more sources of electrolytes including sodium, potassium and magnesium, one or more sources of amino acids including alanine, lysine, phenylalanine, methionine, threonine, leucine, isoleucine, valine, and glutamate, all in a bypass form; and a source of tryptophan. The invention also extends to methods of administering the supplements to livestock to prevent or reduce antemortem stress.

Abstract: A topical composition having improved healing properties, and particularly a lip balm for healing chapped, cracked, sunburned and windburned lips, and comprising up to 35 wt % aloe vera; 3 wt % or more salt; and a pharmaceutically acceptable topical medium.

Abstract: The present invention provides man-made saliva fluids which contain lysozyme chloride in such concentrations as may be able to suppress effectively the development of oral edema and which possess improved feeling of use and show lessened change in appearance and pH value as well as minimized reduction in enzymatic activity of lysozyme chloride after a prolonged period of storage.

Abstract: Compositions for treating animals and surfaces infested with ectoparasites are provided for. The compositions comprise providing a solution consisting essentially of water and sea salt. The solution preferably includes a dissolved skin conditioner, preferably a natural skin conditioner, such as oat grains. The solution is applied to any animal, by dipping, spraying or in an aqueous-based carrier such as a shampoo, in an amount and for a period of time sufficient to deinfest the animal. The composition can be applied in dry form to carpets or lawns where animals lie to prevent infestation or reinfestation of the animal.

Abstract: This invention relates to a composition, preferably in the form of a beverage, whereby cellular hydration and drinkability are enhanced by the combination of green tea solids with selected levels and types of electrolytes and carbohydrates. The compositions comprise (a) from about 0.01% to about 0.35% flavanols; (b) from about 0.01% to about 0.3% sodium ions; (c) from about 0.005% to about 0.08% potassium ions; (d) from about 0.1% to about 20% of a carbohydrate which provides; (i) from about 0.05% to about 10.0% fructose; (ii) from about 0.05% to about 10.0% glucose; and (e) water.

Abstract: Synthetic media formulations are disclosed for use with blood preparations intended for in vivo use, including synthetic media formulations to be employed in conjunction with the photodecontamination of platelets using 8-methoxypsoralen.

Abstract: Methods for treating animals infested with ectoparasites are provided for. The methods comprise providing a solution consisting essentially of water and sea salt. The solution preferably includes a dissolved skin conditioner, preferably a natural skin conditioner, such as oat grains. The solution is applied to any animal, by dipping, spraying or in an aqueous-based carrier such as a shampoo, in an amount and for a period of time sufficient to deinfest the animal.

Abstract: A novel rehydration beverage containing sodium chloride, sodium citrate and aspartame useful for rapid restoration of hydration homeostasis. The beverage is particularly useful for restoration of normal body fluid volumes and their intracellular and extracellular distribution during a hypohydration state observed in astronauts and air passengers.

Abstract: The present invention relates to hypertonic crystalloid resuscitation fluids particularly useful in treating hemorrhagic shock. A pharmaceutical formulation prepared and selected ratios of sodium chloride and sodium acetate with a total osmolar concentration exceeding 500 mOsm can be used as a small volume resuscitation fluid which has little effect on plasma chloride levels. Arterial pressure is improved to the point of sustaining oxygen supply to tissues and organs with a significant increase in oxygen delivery and consumption.

Abstract: A blood substitute employs combinations of fluoro or perfluorochemicals capable in the presence of emulsifying agents of forming emulsions stable at room temperature and possessing enhanced oxygen carrying capacity; the invention enables preparation of an improved blood substitute, with improved O.sub.2 carrying capacity and stability, as well as lessened anaphylactoid reaction.

Abstract: Agglomerated psyllium husk comprising edible acid uniformly dispersed throughout the agglomerating coating. Preferred are maltodextrin-containing agglomerates of psyllium husk comprising citric acid uniformly dispersed throughout the maltodextrin coating. This agglomerated psyllium husk has improved mixability and dispersibility in liquids.

Abstract: A process for treating bovine pericard tissue to increase resistance to biological degradation by wet-chemical processing, The wet-chemical processing consists essentially of: (i) separating any adherent fat and basal membrane from the tissue; (ii) contacting the tissue with an aqueous, alkaline solution of sodium hydroxide, potassium hydroxide, lithium hydroxide or sodium carbonate to swell the tissue; (iii) contacting the swollen tissue with an aqueous sodium chloride solution to control the swelling; (iv) contacting the tissue with a solution of a metal-ion complexing agent with a pH in excess of 11; and (v) contacting the tissue with an aqueous buffer solution having a pH of 4.5 to 6.0. Each of steps (ii)-(v) is followed by a water rinse. The pericard tissue is then dried and sterilized.

Abstract: A method for treating chronic, purulent, middle otitis in children, comprising administering, through a perforation into a middle ear cavity, a freshly prepared donor plasma of one of the parents having the identical blood group to fill up the cavity (1,5-2,0 ml 3-4 times within 24 hours with the preliminary washing of the cavity with a physiological solution prior to each administration.

Abstract: The improved cleansing cream has a wrinkle-reducing effect when periodically applied to and rubbed into the human skin in wrinkled skin areas. The cream is non-irritating to the skin and includes a plurality of water-soluble granules which are of sufficient size, quantity and hardness to abrade the keratinized outer epidermal layer of the skin. The granules may be one or more inorganic salt, but preferably include one or more water-soluble vitamins and/or water-soluble vitamin-yielding salts, The cream also includes a base in which the granules are substantially uniformly disposed. The base preferably is in a major proportion with respect to the granules and is an oil and a petrolatum jelly. The water-soluble granules do not clog the pores of the skin but are absorbed into and nourish the skin.

Abstract: A tissue irrigation solution containing at least one electrolyte compatible with tissue and a nutrient source including at least one member of the citric acid cycle, deprotinated derivatives and salts thereof which may include a free radical scavenger and/or a wetting agent, said solution being a one-part solution and having a stable shelf-life.

Abstract: Antimicrobial metal-based compositions, which are photostable, non-staining, and which are easily absorbed into lipophilic matrices, contain silver cations, complexed by acyclic polyether polymers through the formation of a "host-guest relationship" where the acyclic polyether is the "host" and the silver cation is the "guest," wherein stabilization of this "host-guest relationship" is accomplished through the use of excess halide anions. The compositions are useful for topical treatment of infections caused by bacteria, fungus and viruses in humans and animals and for treating medical devices and adhesives to impart infection-resistance.

Abstract: In a tissue irrigating solution of the type containing the combination of glutathione, bicarbonate, and Ringer solution (GBR), the bicarbonate and glutathione are freeze-dried, packaged and separately stored in lyophilized powder form until just preceding the operation, at which time the lyophilized powder containing the bicarbonate and glutathione is dissolved directly into a conventional I.V. solution.

Abstract: This invention relates to an isotonic energy composition including the carbohydrates, fructose and maltodextrin, the electrolytes, zinc, chromium, calcium, potassium, magnesium, sodium, and the nutrients vitamin C, citric acid and beta carotene. The electrolytes zinc and chromium are delivered in the form of an organic complex. The invention also relates to a method to use the composition.

Abstract: The invention provides a physiologically acceptable solution for treating circulatory shock in mammals which is hyperosmotic as compared to blood plasma. The solution contains a reabsorbable solute and sodium salt in a concentration having an osmolarity in excess of about 1000 mOsms. The physiologically acceptable solution can be easily administered by rapid infusion of 4-6 ml/kg body weight and results in rapid normalization of circulatory function.

Abstract: A method for reducing the proliferation of dust mites in substrates inhabited by dust mites is accomplished by contacting the substrates such as bedding materials, rugs and upholstered furniture with a sufficient amount of finely divided salt which functions as an acaricide against dust mites, thereby killing the dust mites.

Abstract: Therapeutic gels are provided which promote the healing of wounds and which have a minimum yield point of about 800 poise and a maximum apparent viscosity of about 100,000 cps, which gels comprise water, sodium chloride, and a gelling agent.

Abstract: The present invention relates to a hypertonic crystalloid resuscitation fluid particularly useful in treating circulatory shock arising from loss of blood. A pharmaceutical formulation prepared from sodium chloride in a range of about 2-7 osmolar parts and sodium acetate in a range of about 1-2 osmolar parts where the total osmolar concentration exceeds 500 mOsm can be used as a small volume rapid bolus resuscitation fluid which has little effect on plasma chloride levels. Blood flow is improved while arterial pressure is improved to the point of sustaining oxygen supply to tissues and organs in the recumbent recipient.

Abstract: Disclosed here are novel compositions and methods which can be used as a blood substitute to ameliorate adverse physiological effects of blood loss. The novel compositions comprise fluids containing water, electrolytes, glycerol, and additional energy sources.

Abstract: Disclosed here are novel compositions and methods which can be used to reduce or prevent adverse physiological effects of physical exercise or environmental exposure. The novel compositions comprise fluids containing water, sugar, electrolytes, and a substance which is non-toxic to man or animals, can be rapidly absorbed through the gastrointestinal tract, prevents decreases in blood volume, and acts as an energy source.

Abstract: Psyllium husk-containing drink mix compositions comprising small particle size psyllium husk and edible, water soluble salts. The edible, water soluble salts are present at a level sufficient to reduce the gellation rate of the psyllium husk when dispersed in an aqueous solution.

Abstract: Irrigating solutions with thiol or disulfide containing compounds in physiologically acceptable salt solutions are described. The irrigating solutions are useful during surgery, particularly ophthalmic, neural, cardiovascular or otic surgery, to stabilize the affected tissue. Methods for their preparation and use are described.

Abstract: Composition in the form of a solution for inducing and stimulating hair-growth and for decreasing hair loss, said solution is a 100% saturation of purified sodium chloride fully dissolved in purified Aloe Vera.

Abstract: Methods are provided for preparing just before administration unit doses of therapeutic solutions which contain redox active unstable and/or diffusable metabolites such as a ketoacid, a sulfhydryl-contining amino acid, or carbon dioxide. The method involves preparing and storing an aqueous solution of stable components which may or may not contain carbon dioxide. A dry powder comprised of unstable components is also prepared and stored separately. These separate component compositions are packaged in, for example, individual chambers of a common scaled container which is so constructed as to permit the opening, by externally applied manual means or the like, of a passageway between such chambers at the time when usage is contemplated. Thus, a fresh solution in desired full dosage form is preparable just befor administration. Improved container structures for practice of this method are also provided.

Abstract: A bath additive is proposed which has a base of vegetable or animal raw materials containing an aqueous solution of a mixture of amphoteric, anionic and nonionic substances having a base of a vegetable and/or animal oil and an alcoholic solution having a base of one or more medicinal plants. The bath additive is used as agent for the treatment of microbially-induced as well as chronically endogenous skin diseases.

Abstract: Cardioplegia solutions having potassium and chloride ion concentrations selected to give a product approximately equal to the product of the potassium and chloride ion concentrations in blood and blood substitutes have been shown to prevent heart cell swelling during cardioplegia.

Abstract: A blood substitute suitable for replacing blood in mammalian subjects when performance of surgical procedures at hypothermic temperatures is described. The blood substitute comprises water, electrolytes at physiological concentration, dextran 40 at a concentration sufficient for the blood substitute to achieve a colloidal suspension having a fluid osmotic pressure essentially equivalent to mammalian plasma, HEPES buffer at a physiological pH, dextrose, magnesium ion at a concentration of about 0.01M and potassium ion at a concentration greater than 10 mEq per liter sufficient to prevent or arrest cardiac fibrillation. In one embodiment the blood substitute is a multi-solution system wherein the solutions comprise differing levels of the above-indicated components and are administered sequentially to completely replace a subjects circulating blood.

Abstract: The present invention relates to a dermatological composition composed for cosmetics or medicines for external application to skin and to oral or nasal mucous-membrane. This composition can be applied in particular in the cosmetic or pharmaceutical field, especially in the dermatological cases to regenerate and to revitalize damaged cells by equilibrating electrochemical ion gradients across cell membrane and also by osmotic pressure on the inner face of the cell membrane. A composition based on a water phase in accordence with present invention comprises dextran, glucose, mutan lentinan, NaCl, KCl, and CaCl.sub.2, which are dissolved in the aqueous phase.

Abstract: The invention provides an orally administered pharmaceutical composition for use in gastrointestinal washes, particularly for diagnostic use, or as a cathartic laxative, of the type containing polyethyleneglycol, anhydrous sodium sulphate, sodium bicarbonate, sodium chloride and potassium chloride, characterized by also containing the following components: saccharin, acesulfame-K and a flavoring chosen from the following: mandarin, fresh fruit flavoring.

Abstract: Skin treatment solution and method having an aqueous, dissociable, sodium salt solution with a pH in the 6.0-8.0 range and containing enough sodium to substantially remove testosterone from the skin area to which the solution is applied topically. The sodium salt solution has sodium chloride as the major salt constituent and much smaller amounts of choline chloride, inositol, pantothenic acid and vitamin E, as well as a surfactant and sodium fluoride as a preservative.

Abstract: A topical application composition for mitigating male pattern baldness and testosterone-induced acne contains, as essential active, androgen-reducing components (a) a testosterone-reducing amount of an ionizable sodium salt, and (b) an association of compounds for forming, androgen segregating cellular proliferation phospholipids. The association includes lecithin, soy oil, phosphoric acid, choline chloride and optionally inositol and a nonionic surfactant in an amount for solubilizing and/or dispersing components (a) and (b) in a cosmetically-compatible vehicle for topical application.

Abstract: Disclosed is a novel therapy involving infusion of specially adapted electrolyte solution comprising essentially physiological concentrations of sodium and other cations and in general higher than physiological concentrations of bicarbonate. The therapy is related to treatment of altered renal function and prophylactic treatment of a patient to resist onset of altered renal function.

Abstract: In a tissue irrigating solution of the type containing the combination of glutathione, bicarbonate, and Ringer solution (GBR), the chloride salts (Ringer solution) are packaged and stored in solution and the bicarbonate and glutathione are freeze-dried and packaged and separately stored in powder form until immediately preceeding the operation, at which time the bicarbonate and glutathione are dissolved directly into the solution of chloride salts. The resulting solution is mixed within 24 hours of use.

Abstract: Processes and compositions are provided for accomplishing fluid therapy using the anions l-lactate, pyruvate, d-betahydroxybutyrate, acetoacetate, or mixtures of such. The racemic d,l-lactate or acetate anion mixtures heretofore used in fluids are now known not to be desirable because they cause adverse and toxic effects when administered to mammals.

Abstract: The invention provides novel improved oxygenated fluorocarbon nutrient solutions for treatment of hypoxic-ischemic neurologic tissue in mammals. The invention also provides methods of making such nutrient solution and methods of administering them.

Abstract: The invention provides a pasty composition for perfusing artificial kidney systems for dialysis, the composition comprising about 30 to about 70% by weight of solid electrolyte components consisting of NaCl, KCl, CaCl.sub.2, MgCl.sub.2 and CH.sub.3 COONa and about 70 to about 30% by weight of water, and the composition having a viscosity of about 1,000 to about 7,000 cps at 25.degree. C., and also provides a process for preparing a pasty composition for perfusing artificial kidney systems for dialysis, the process comprising the steps of uniformly mixing NaCl, KCl, CaCl.sub.2, MgCl.sub.2 and CH.sub.3 COONa, adding water and finely dividing the mixture.

Abstract: The present invention provides a method of preventing blood from clotting in a filter during continuous arteriovenous or venovenous hemodialysis on a patient comprising administering to the blood an amount of citrate sufficient to prevent clotting in the filter. The invention preferably utilizes a dialysate having a sodium and calcium concentration below that of normal blood and an alkali concentration sufficiently low to reduce or prevent alkalosis.

Abstract: A veterinary composition useful for treatment of energy depletion, dehydration and electrolyte imbalance in diarrhoeic neonatal animals consisting essentially of(a) glucose in an amount sufficient to produce a concentration level of from greater than 200 nM to 250 mM when in an aqueous solution,(b) one or more sodium salts in an amount sufficient to produce a sodium ion concentration level of from 60 mM to 120 mM when in an aqueous solution, and(c) one or more chloride salts in an amount sufficient to produce a chloride ion concentration level of 50 mM to 90 mM when in an aqueous solution.

Abstract: Nitrogen-free thickeners in aqueous surfactant solutions comprising polyethoxylates of mono- and/or polyunsaturated C.sub.12 -C.sub.22 fatty alcohols having an average degree of ethoxylation of 2 to 5, which also contain 1 to 2 terminal propylene oxide groups attached by condensation instead of the corresponding number of ethylene oxide groups. The products may also be used in admixture with dissolved inorganic electroltye salts and with polyethoxylates of saturated fatty alcohols. These surfactant solutions are useful in the formulation of personal hygiene preparations such as hair shampoos, foam baths, shower baths, handwashing pastes and the like.

Abstract: Disclosed here are novel compositions and methods which can be used to reduce or prevent adverse physiological effects of physical exercise or environmental exposure. The novel compositions comprise fluids containing water, sugar, electrolytes, and a substance which is non-toxic to man or animals, can be rapidly absorbed through the gastrointestinal tract, prevents decreases in blood volume, and acts as an energy source.

Abstract: A blood substitute suitable for replacing blood in mammalian subjects when performance of surgical procedures at hypothermic temperatures is described. The blood substitute comprises water, electrolytes at physiological concentration, dextran 40 at a concentration sufficient for the blood substitute to achieve a colloidal suspension having a fluid osmotic pressure essentially equivalent to mammalian plasma, HEPES buffer at a physiological pH, dextrose, magnesium ion at a concentration of about 0.01M and potassium ion at a concentration greater than 10 mEq per liter sufficient to prevent or arrest cardiac fibrillation. In one embodiment the blood substitute is a multi-solution system wherein the solutions comprise differing levels of the above-indicated componants and are administered sequentially to completely replace a subjects circulating blood.