Abstract: A lignocaine or a salt, ester or metabolite thereof for use in initiating the natural capacity of regeneration of collateral blood vessels.

Abstract: A solution, in particular for hemodialysis or peritoneal dialysis that permits attaining a desired glucose concentration without affecting the concentrations of other components in the solution. The solution consists of at least three individual solutions that are combined and administered after heat sterilization. The first solution contains calcium ions, electrolyte salts and optionally glucose in a concentration of 0-1000 mM and is acidified to a pH of less than 4.0 with a physiologically tolerable acid. The second solution contains glucose in a concentration different from that of the first solution and the remaining components of the first solution in the same concentration. The third solution contains a buffer in the physiological range. Also provided is a method of preparing a solution according to the invention, where the desired mixing ratio of the separate solutions is automatically established by a dialysis machine or peritoneal dialysis cycler.

Abstract: A method of preparing a solution is described, in particular a dialysis or infusion solution, and a storage system for preparing such a solution. An acid-reacting component comprising a solid acid and/or a solid salt which is water-soluble and is not hygroscopic, is dissolved in water in a first container and mixed with an alkaline-reacting bicarbonate solution in a second container. The quantity ratios are selected so that the acid and/or salt content does not exceed 6 mmol per liter of finished solution and the bicarbonate content does not exceed 40 mmol per liter of finished solution.

Abstract: Methods and pharmaceutical compositions for protecting pharmaceutical compounds (or drugs) in acidic environments are provided. Methods of treatment using formulations capable of protecting pharmaceutical compounds in acidic environments are also provided. Formulations provided generally comprise a therapeutically effective amount of at least one pharmaceutical compound, and a pharmaceutically acceptable protectant. The pharmaceutically acceptable protectant of the invention generally comprises a water-soluble acid neutralizer, and a water-insoluble acid neutralizer.

Abstract: A composition is provided that is suitable for topical administration for the treatment of a skin irritation, the composition comprising acetylsalicylic acid and sodium bicarbonate. Also provided is a method for treating a skin irritation in an individual comprising topically administering to the affected area a therapeutically effective amount of a composition comprising acetylsalicylic acid and sodium bicarbonate. The composition is particularly useful for decreasing the temperature at the surface of a sunburn and for reducing pain and discomfort caused by a sunburn.

Abstract: A solid orally administrable pharmaceutical dosage form for the treatment of gastric disorders includes a first portion containing a therapeutically effective amount of a histamine H2-receptor antagonist, and a second portion immediately adjacent the first portion without an intervening barrier disposed between the first portion and the second portion, the second portion containing a therapeutically effective amount of an antacid. Physical separation of the active ingredients into two different portions without a separating barrier has been found sufficient to prevent degradation of the histamine H2-receptor antagonist due to contact with the antacid. The invention therefore provides stabilization of a histamine H2-receptor antagonist-antacid combination tablet which is comparable to known multiple portion tablets, but without an intervening barrier between the antacid portion and the histamine H2-receptor antagonist portion.

Abstract: The present invention comprises a method and composition for treating skin disorders such as seborrheic dermatitis of the scalp, dandruff, and psoriasis. The method includes topically applying to the skin a solution containing a treatment composition comprising one or more types of alkaline buffers such as bicarbonate, carbonate, dibasic phosphate, and tribasic phosphate having a pH in the range of about 7.1 to about 10.8 and a cation such as potassium or sodium serving as a counter ion. The treatment composition is delivered in a pharmaceutically acceptable vehicle at concentrations that vary according to both the severity of the skin disorder, the buffer vehicle, and the ingredients themselves. This biologically benign treatment has been found to efficiently and very quickly treat several types of skin disorders, including but not limited to the redness, dandruff and itching that can occur following skin cleansing with soap.

Abstract: A method of treating gastric acid disorders by administering to a patient a pharmaceutical composition comprising a proton pump inhibitor (PPI) in a pharmaceutically acceptable carrier.

Abstract: Food products and methods for synthesizing food products for reducing naturally occurring radioactive potassium isotope (40K) in the human body requires separating the radioactive potassium isotope (40K) from the non-radioactive isotopes (i.e. 39K) in potassium. Various food products can then be prepared using the 39K. These food products include manufactured products, such as sports drinks, baking soda, and dietary tablets, as well as altered liquid food products, such as orange juice and tomato juice.

Abstract: A slurry comprising (a) sodium bicarbonate, (b) sodium chloride, and (c) water, in a weight ratio of (a)/(b) of about 2.5:1 to about 3.5:1, wherein upon further dilution of said slurry with additional water, the amount of sodium bicarbonate and sodium chloride which dissolves into said additional water is in the same ratio as said of (a)/(b) in said slurry before said additional dilution.

Abstract: The present invention relates to an agent for reducing scar formation, which inhibits the scar formation by injecting sodium bicarbonate to the dermis tissue of the wound with a syringe to directly control pH of the wound site, namely, by alkalinizing the wound to inactivate TGF-&bgr;. According to the present invention, the agent for reducing scar formation by controlling the wound healing process can be clinically and immediately applied to the treatment of tylosis scar and keloid, etc., and is effective to the treatment of intractable fibrosis diseases. Also, the invention can be widely applied in many ways as an easy tool which can control the action of TGF-&bgr; in a living organism.

Abstract: A topical composition and method for the treatment of the symptoms of diaper rashes and skin irritations by creating an air circulating mechanism comprising a) bicarbonate of soda; b) corn starch; c) citric acid; d)a carrier oil; e) a pharmaceutically acceptable moisturizer, f) fragrance oil; and g) food grade coloring. The carrier oil is selected from the group consisting of almond oil, coconut ail, sunflower oil, apricot kernel oil, avocado oil, canola oil, evening primrose oil, grapeseed oil, hazelnut oil, jojoba oil, macadamia oil, dive oil, sesame oil, rosehip seed oil, and mixtures thereof. The pharmaceutically acceptable moisturizer is either purified water or witch hazel. In its preferred embodiments, the composition can result in a loose powder for application directly to the diapered skin, an effervescent bath tablet, and as an additive to the bodyfacing layer of a diaper.

Abstract: A topical composition and method for the treatment of the symptoms of diaper rashes and skin irritations caused by acidic secretions comprising a) a pH-raising ingredient selected from the group consisting of sodium hydrogen carbonate (bicarbonate of soda), magnesium hydroxide, calcium carbonate, aluminum hydroxide, and mixtures thereof; b) an anhydrous base ointment; c) polysorbate 80; d) a pharmaceutically acceptable diluent; and e) butylated hydroxy toluene, wherein said pharmaceutically acceptable diluent is purified water. The pH of the topical composition is adjusted by adding droplets of glacial acetic acid. The composition can also further comprise AQUAPHOR™. Embodiments disclosed include a cream, dusting powder, spray, bath soak and effervescent tablet, and also the application of the lotion composition to a bodyside diaper liner.

Abstract: Oral composition comprising: (a) an alkyl hydroxybenzoate represented by formula 1  wherein R represents an alkyl group comprising at least five carbon atoms, and (b) said composition having an alkaline pH.

Abstract: A method of treating gastric acid disorders by administering to a patient a pharmaceutical composition comprising a proton pump inhibitor (PPI) in a pharmaceutically acceptable carrier.

Abstract: Bicarbonate containing solutions for use during medical treatment are provided. The bicarbonate containing solution of the present invention includes at least two separate components including a bicarbonate concentrate and an electrolyte concentrate which can be readily and sterilely mixed to form a ready-to-use formulation for patient administration, particularly as applied to the treatment of acute renal failure associated with critically ill patients in an intensive care setting.

Abstract: Improved stability surgical irrigating solutions and methods of use are disclosed. The compositions comprise bifunctional compounds (i.e., compounds comprising antioxidant and antiinflammatory moieties) and physiological antioxidants to stabilize the bifunctional compounds. The compounds are useful in preventing and treating inflammatory and other disorders incident to surgery.

Abstract: A fungicide for the treatment of skin aliments prepared by mixing three parts aquamarine salts having a chloride to sodium ratio of 1.4:1, two parts ionized sodium chloride and one part sodium bicarbonate by weight. The dry mixture is blended then dissolved in water in the amount of four table spoons of mixture to one liter of water as a soaking bath for affected area of skin and nails. The mixture can also be dissolved to form a vaginal bath by dissolving two tablespoons of mixture into 16 ounces of water. The mixture may be ground into a fine powder and added to equal amounts by weight of petroleum gel to form a salve that is applied to affected areas for prolonged application. Food color may be added to provide aesthetic qualities to the mixture and resulting bath and douche.

Abstract: A method of treating gastric acid disorders by administering to a patient a pharmaceutical composition comprising a proton pump inhibitor (PPI) in a pharmaceutically acceptable carrier.

Abstract: Methods and compositions for providing glutamine supplementation to a human by orally administering an effective amount of N-acetyl-L-glutamine or a nutritionally acceptable salt thereof. The N-acetyl L-glutamine or a nutritionally acceptable salt thereof can be incorporated into any liquid composition that is suitable for human consumption. Examples of suitable compositions include aqueous solutions such as for use as oral rehydration solutions and liquid nutritional formulas (including enteral formulas, oral formulas, formulas for adults, formulas for children and formulas for infants). The quantity of N-acetyl-L-glutamine or nutritionally acceptable salt thereof can vary widely but typically, these compositions will contain sufficient N-acetyl-L-glutamine or a nutritionally acceptable salt thereof to provide at least 140 mg of total glutamine per kg of body weight per day.

Abstract: This invention provides deodorant and deodorant-antiperspirant cosmetic stick and roll-on products with an organic matrix having a dispersed phase of discrete particles of an encapsulated bicarbonate salt such as sodium bicarbonate, and discrete particles of an encapsulated fragrance compound such as musk ketone. The particle surfaces are coated with a polymer such as maltodextrin starch. When this type of cosmetic product is applied to underarm surfaces, the deodorizing activity is signaled by the release of a fragrance aroma.

Abstract: An aqueous neutral to mildly alkaline metal bicarbonate solution is disclosed. The solution comprises metal bicarbonate dissolved in the solution, the metal bicarbonate comprising bicarbonate anions and metal cations. In addition there is a pH adjusting agent in the solution in an amount whereby the solution is at a neutral to mildly alkaline pH. Also disclosed is a process of preparing an aqueous neutral to mildly alkaline metal bicarbonate solution comprising bicarbonate anions and metal cations. The process comprises reacting a compound selected from the group consisting of metal carbonate, metal carbonate hydroxide, metal oxide, metal hydroxide and any mixture thereof with an effective concentration of a pH adjusting agent to produce the aqueous neutral to mildly alkaline metal bicarbonate solution, wherein the pH adjusting agent is present in an amount whereby the solution is at a neutral to mildly alkaline pH.

Abstract: This invention relates to a buffered phosphorus containing solution comprising at least one phosphorus compound selected from the group consisting of phosphorous acid, hypophosphorous acid, polyphosphorous acid polyhypophosphorous acid, and salts thereof. The solution also contains a buffer including an organic base in the form of a nitrogen containing compound and its conjugate acid. The solution may be used as a fertilizer or as a fungicide. The invention also relates to a method of preparing such a solution.

Abstract: A safe and effective composition that can be taken orally to restore proper balance in pH and trace mineral levels to an individual who exhibits a need for such adjustment. In one embodiment it may be used topically to promote healing of skin lesions and sores. It contains mineral salts and catalyst-altered water in an aqueous solution and may also contain ethanol.

Abstract: A formulation consisting of sodium bicarbonate, sodium carbonate and trisodium phosphate in aqueous solution is applied topically to treat an array of skin and tissue problems. The solution offers antibacterial, antiseptic, anti-fungal, and healing properties to skin scratches, cuts, sores, and fungal infected nails. In addition, the solution dries as a thin film to the applied surfaces, continuously providing antibacterial, anti-fungal and antiseptic activity beneath the protective film long after it has been applied.

Abstract: A method for treating gastric acid disorders with a non-enteric coated proton pump inhibitor in a pharmaceutically acceptable carrier including a bicarbonate salt of a Group IA metal and a carbonate salt of a Group IA metal; and a pharmaceutical composition of a non-enteric coated proton pump inhibitor in a pharmaceutically acceptable carrier including a bicarbonate salt of a Group IA metal and a carbonate salt of a Group IA metal are disclosed. A presently preferred proton pump inhibitor is lansoprazole, a presently preferred bicarbonate salt is sodium bicarbonate, and a presently preferred carbonate salt is sodium carbonate. The composition is a fast-acting formulation which reduces the undesirable belching associated with proton pump inhibitor formulations that contain high doses of sodium bicarbonate.

Abstract: This invention provides a feedstock for controlling hypocalcemia in prepartum dairy cattle. An essential feature of the feedstock is a dietary cation-anion difference (DCAD) with a value between about −5 and +20 meq/100 g dietary DM. Other essential features are a weight ratio of potassium:magnesium between about 3-5:1, and between about 1-12 g/kg dietary DM of omega-6 fatty acid derivative having rumen-bypass properties.

Abstract: This invention provides substantially spherical, micron and submicron sized alkali metal bicarbonate particles. When combined with a liquid medium, the alkali metal bicarbonate particles have an exceptional capability to form a flowable slurry which demonstrates long term stability.

Abstract: The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts—an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.

Abstract: A solid preparation for dialysis for preparing a double preparation type sodium bicarbonate solid preparation for dialysis in which there is no fear that a sugar is decomposed or colored, and which can maintain stability and also is excellent in content homogeneity and a process for producing the same. The solid preparation for dialysis is a mixture of a first composition composed of core particles including sodium chloride that are coated with a coating layer containing one or more electrolytes, a second composition composed of core particles including a sugar that are covered with a coating layer containing one or more electrolytes, and an acid.

Abstract: Pharmaceutical compositions for rectal administration comprising an effervescent mixture comprising sodium bicarbonate and glutamic acid or pyroglutamic acid with at least one diluent adapted for rectal administration, said mixture being effervescent.

Abstract: A regimen for hunting includes using a number of activated carbon-containing personal items in connection with a hunter's apparel and body to reduce the hunter's scent for improved hunting. The personal items include mouthwash, deodorant/antiperspirant, body and boot powder, bar and liquid soap for cleansing the body and hair, laundry detergent and dryer sheets. Each of the personal items includes an effective amount of activated carbon, so that use of the personal items reduces the available scent to be detected by animals in the wild.

Abstract: A method for washing produce to inhibit or eliminate decay due to pathogens comprises washing the produce using a solution of alkaline salt of bicarbonate under conditions effective to inhibit or eliminate produce decay. Preferred embodiments include spraying the produce under pressure with a solution of alkaline salt of bicarbonate under preferred conditions, and immersing the produce in a solution of alkaline salt of bicarbonate and a sanitizing agent. Also, an apparatus for preventing or eliminating produce decay comprises components to facilitate use of the method of washing produce.

Abstract: A formulation consisting of sodium bicarbonate, sodium carbonate and trisodium phosphate in aqueous solution is applied topically to treat an array of skin and tissue problems. The solution offers antibacterial, antiseptic, anti-fungal, and healing properties to skin scratches, cuts, sores, and fungus-infected nails. In addition, the solution dries as a thin film to the applied surfaces, continuously providing antibacterial, anti-fungal and antiseptic activity beneath the protective film long after it has been applied.

Abstract: The invention relates to an alimentary integrator constitued by a compound of potassium bicarbonate (KHCO3) and an anti-oxidant agent that comprises D ribose (C6H10O5) and that can comprise ascorbic acid L (C6H8O6).

Abstract: Methods of administering camptothecin compounds such as irinotecan hydrochloride to reduce a diarrhea side effect and methods of treating cancer and AIDs with camptothecin compounds including administering the camptothecin compounds while maintaining the intestinal lumen and the bile at an alkaline pH.

Abstract: A neutral glucose-containing preparation with excellent stability and a near physiological pH, as a transfusion preparation with minimal glucose degradation by-products and a greatly reduced formic acid content; specifically, a glucose-containing preparation comprising separately housed first and second solutions, the first and second solutions satisfying the following conditions: (a) the first solution contains 2-50% glucose, and its pH is adjusted to 3-5 with an organic acid buffer solution; (b) the second solution contains an alkalizing agent, and has a pH value of 8-13 as a pH adjustor for the first solution; and (c) the glucose concentration is 1-15% in the preparation solution obtained by mixing the first solution and second solution, and the pH of the solution is in a range of 6-8. It is used particularly as a peritoneal perfusate, such as a perfusate for Continuous Ambulatory Peritoneal Dialysis (CAPD).

Abstract: An aqueous pourable liquid composition comprising a high concentration of sodium alginate and an alkali metal bicarbonate, wherein the sodium alginate has an average mannuronic acid residue to guluronic acid residue ratio of at least 0.6:1. In addition, an alginate or alginic acid for forming a protective coating on gastrointestinal mucosal tissue, use of and compositions including the same are provided.

Abstract: A disposable absorbent article is provided with a odor control powder which is unscented in a dry state and releases a burst of fragrance when wetted, such as by human waste. The powder contains a relatively small amount of fragrance oil, such as 0.5% to 4% by weight, to prevent skin irritation to the wearer. The small amount of fragrance oil is microencapsulated in a starch which constitutes from about 50% to 90%, and preferably about 70%, of the total weight of the particles. Sodium bicarbonate is also included in the particulate odor control material in an amount ranging from 5.0% to 45%, and preferably about 25% by weight, of the total weight of the particles. The sodium bicarbonate promotes skin wellness by controlling the pH levels of the fragrance oil, starch and human waste. A small amount of flow agent is also contained in the particulate odor control material.

Abstract: A peritoneal dialysis solution that is biochemically balanced to correct metabolic acidosis associated with chronic renal failure in a more physiological manner. The peritoneal dialysis solution has a physiological pH, e.g., pH of 7.0 to 7.4, and contains bicarbonate at a concentration that is found in blood involved in Additionally, the solution contains carbon dioxide at a partial pressure that is similar to partial pressure of carbon dioxide found in the blood capillaries. The peritoneal dialysis solution also contains a weak acid with a pKa of less than 5.0.

Abstract: A formulation consisting of sodium bicarbonate, sodium carbonate and trisodium phosphate in aqueous solution is applied topically to treat an array of skin and tissue problems. The solution offers antibacterial, antiseptic, anti-fungal, and healing properties to skin scratches, cuts, sores, and fungal infected nails. In addition, the solution dries as a thin film to the applied surfaces, continuously providing antibacterial, anti-fungal and antiseptic activity beneath the protective film long after it has been applied.

Abstract: A pain relief preparation for use while bathing for soothing and relaxing a user's body. The pain relief preparation for use while bathing includes (A) salts; (B) sodium bicarbonate; (C) an alkaline solution; (D) a bulb; and (E) aromatic seeds for use with water upon a user's body.

Abstract: The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts—an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.

Abstract: The compound curcumin, derived from turmeric, inhibits phosphorylase kinase and, by doing so, exhibits a number of physiological effects related to the control of inflammation and cellular proliferation. However, curcumin is effective only when in solution. Curcumin is almost completely insoluble in water or in oils, but is soluble in alcohols. Accordingly, a method for treating inflammation in a mammal comprising administering curcumin in a solution containing at least one alcohol to a mammal to detectably inhibit the activity of phosphorylase kinase in the blood of the mammal or in a tissue of the mammal. The alcohol is preferably ethanol, 1-propanol, or 2-propanol; most preferably, it is ethanol. Instead of curcumin, a curcumin derivative or curcuminoid can be administered.

Abstract: An aqueous neutral to mildly alkaline metal bicarbonate solution is disclosed. The solution comprises metal bicarbonate dissolved in the solution, the metal bicarbonate comprising bicarbonate anions and metal cations. In addition there is a pH adjusting agent in the solution in an amount whereby the solution is at a neutral to mildly alkaline pH. Also disclosed is a process of preparing an aqueous neutral to mildly alkaline metal bicarbonate solution comprising bicarbonate anions and metal cations. The process comprises reacting a compound selected from the group consisting of metal carbonate, metal carbonate hydroxide, metal oxide, metal hydroxide and any mixture thereof with an effective concentration of a pH adjusting agent to produce the aqueous neutral to mildly alkaline metal bicarbonate solution, wherein the pH adjusting agent is present in an amount whereby the solution is at a neutral to mildly alkaline pH.

Abstract: The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts—an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.

Abstract: A composition useful as a dietary supplement for providing potassium, calcium, and citrate is presented, as well as processes for producing the composition, and methods for using the composition as a dietary supplement. Administration of the composition counters bone loss associated with aging or menopause by providing bioavailable calcium and, simultaneously, delivering alkali load. In addition, administration of the composition produces a substantial increase in urinary citrate, which counters kidney-stone formation.

Abstract: The use of silica for controlling the thermal degradation of bicarbonate of an alkaline, alkaline-earth metal or bicarbonate of ammonia with an average particle size less than or equal to 100 &mgr;m is disclosed. The resulting bicarbonate and silica mixtures may be used in cosmetics and detergents, and more particularly in formulae for toothpaste.

Abstract: A composition for prevention and extermination of plant disease which comprises a biocidal inorganic compound, an amphoteric surfactant, and at least one member selected from the group consisting of a nonionic surfactant and an anionic surfactant. The composition exhibits residual activity for a long period of time without phytotoxicity.

Abstract: A method for whitening teeth which utilizes laser light to activate bleaching agents applied to the teeth. The mouth is first prepared so that the soft tissues of the gums are protected and only the teeth are exposed. The teeth are cleaned to remove any materials which will reduce or nullify the effects of the bleaching agents. A first bleaching composition comprising a peroxide compound is prepared and applied to the teeth. The teeth are exposed to laser light from an argon laser which light activates the peroxide to accelerate the bleaching process without heat. If further whitening is desired, a second bleaching composition comprising a peroxide compound is prepared and applied to the teeth. The teeth are briefly exposed to laser light from a carbon dioxide laser which heat activates the peroxide to accelerate the bleaching process.