Abstract: A composition comprising the reaction product of (a) an isocyanate group-containing component having an average functionality of at least 2; and (b) an active hydrogen group-containing component having an average functionality of at least 2. The composition is biodegradable, a solid at 22° C. and below, and has pressure sensitive adhesive properties at a temperature of 37° C. and relative humidity of 100%. The composition may be used to adhere polymer meshes or films to biological tissue.

Abstract: A topical skin care lotion includes materials for supplementing the production of collagen I and III includes a base of lipophillic or lipophobic material and at least one amino acid. The amino acids are alanine and glycine. Other components of the lotion include iron, vitamin C, manganese, silica and cherry fruit extract. Together, these components assist the body with the production of collagen and promote healing of damaged skin. Antioxidants are also provided to protect the skin from oxidative stress by ultraviolet sunlight and environmental hazards.

Abstract: Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.

Abstract: The present invention relates to a process for producing a hydroxy amino polymer comprising the steps: a) Reaction of an H functional starter compound bearing at least one Zerewitinoff active H atom with an unsaturated, cyclical carboxylic acid anhydride and at least one alkylene oxide compound for obtaining a prepolymer bearing hydroxyl groups, b) Addition of a primary amine and/or of ammonia to the double bond(s) of the prepolymer bearing hydroxyl groups obtained according to step a) for obtaining the hydroxy amino polymer, wherein the ratio of added amino groups to hydroxyl groups in a hydroxy amino polymer is at least 0.6. Furthermore, the invention relates to a hydroxy amino polymer, which can be achieved according to this process as well as a polyurea/polyurethane system, which contains such a hydroxy amino polymer.

Abstract: Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.

Abstract: The present invention refers to the use of growth factors, which are effective on mesothelial cell proliferation, used in a sterilized carboxymethylchitosan pharmaceutical composition employed to reduce postoperative adhesions severity. The present invention also provides a method to inhibit postoperative adhesions severity.

Abstract: A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein the sterilized cyanoacrylate adhesive composition does not cure upon sterilization. A kit for applying the sterilized cyanoacrylate adhesive composition, including the cyanoacrylate adhesive composition and an applicator. A method of making the sterilized cyanoacrylate adhesive composition, by adding a cure speed enhancer to a cyanoacrylate adhesive composition and sterilizing the composition. A method of applying the sterilized cyanoacrylate adhesive composition to tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid, and quickly curing the sterilized cyanoacrylate adhesive composition. A method of sealing tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid to tissue to be sealed, quickly curing the sterilized cyanoacrylate adhesive composition, and sealing the tissue.

Abstract: The present invention describes therapeutic compositions comprising fibroblasts that have been stimulated to increase expression of extracellular matrix components or elastin, or to produce enhanced elastogenesis or the appearance thereof at a site of administration. The therapeutic fibroblast formulations can be prepared using a variety of elastogenic agents, including digests of mammalian elastin, chemically digested plant extracts comprising elastin-like peptides, and synthetic elastogenic peptides. The invention further comprises cosmetic and pharmaceutical treatment methods using the therapeutic fibroblast compositions of the invention.

Abstract: The present invention is directed to cosmetic compositions having an unique texture and feel containing: (a) at least one polyamine; (b) at least one oil-soluble polar modified polymer; (c) water; (d) optionally, at least one volatile solvent, other than water; (e) at least one non-volatile oil capable of solubilizing the oil-soluble polar modified polymer; and (f) optionally, at least one colorant.

Abstract: Various topical compositions for skin care are disclosed. These topical composition include: one or more acidic fermentation products derived from one or more (C1-C6) unsubstituted straight chain alcohols and branched alcohols; one or more alkali metal halides; one or more polysaccharides; and water. Methods of treating acne, seborrheic dermatitis, effects of ageing, blemishes, cleansing and treating skin, and the like, with these various topical compositions are also provided.

Abstract: The present invention relates to hair care and personal care compositions which contain an acrylic copolymer which is polymerized in the presence of at least two different classes of crosslinking monomers. The polymer functions both as a fixative/film former and a thickening agent for hair styling and personal care compositions in which it is contained. The copolymer exhibits advantageous fixative, film forming and rheological gel properties.

Abstract: A molecule for stabilizing a bioactive chemical group capable of releasing nitric oxide in vivo is described. The molecule possesses multi-functionality, enabling the delivery of multiple nitric oxide precursors on a single molecule. In some embodiments, a tissue or prosthetic bonding group is attached to one of the functional arms of the molecule making the molecule of the present invention localizing to tissue or an implant.

Abstract: A composition is provided to apply to the skin, hair, or external mucosa of a human or animal, and a method for using the composition. The composition includes for example a composition for application to skin, hair or external mucosa comprising: a) dispersed submicron particles of hydrophobic agent(s) having average particle size from 100 nm to 999 nm; b) an aqueous-solvent fluid; and c) rheological modifying agent(s); wherein the aqueous-solvent fluid is 10% to 95% wt. of one or more water miscible solvent(s), 4.99% to 89.99% wt. water, and 0.01% to 10% wt. of the rheological modifying agent(s); and wherein the hydrophobic agents comprise 0.01 to 70% wt. of the skin, hair or mucosal composition; and wherein the composition is substantially surfactant-free.

Abstract: The invention described herein relates to a therapeutic, moisturizing coating composition for elastomeric articles which is applied directly onto the skin-contacting surface of the article as part of the manufacturing process. The coating composition is thermally stable and subsequently hydrates when contacted with a moisturized skin surface to convert into a liquid “lotion” form during wearing of the article. The coating composition provides therapeutic benefits to the wearer's skin as a result of wearing the article, such as improved skin moisturization, softness of feel, improved skin elasticity and firmness, and reduced redness and irritation. The invention is particularly useful in medical gloves, including examination and surgical gloves.

Abstract: This invention relates to methods and compositions for degrading collagen in mammalian skin, thereby improving the appearance and/or reducing the size of a closed wound, which may be a scar or a keloid and cellulite or other conditions wherein excessive collagen is a problem.

Abstract: This invention relates to methods and compositions for degrading collagen in mammalian skin, thereby improving the appearance and/or reducing the size of a closed wound, which may be a scar or a keloid and cellulite or other conditions wherein excessive collagen is a problem.

Abstract: An emulsion composition comprising: an aqueous component, a non-ionic block copolymer, and an oil wherein the copolymer comprises at least 10% by weight of the composition.

Abstract: Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.

Abstract: The present invention relates to a personal care composition additive for use on keratin substrates in order to provide long lasting benefits to the keratin substrate such as in conditioning systems, such as 2/1 shampoo's, leave-on and rinse off conditioners, for hair and skin, or for imparting greater water resistance to such personal care compositions as sunscreens or cosmetics.

Abstract: The disclosure provides compositions and systems for topical ophthalmic application, which include an aqueous mixture of bromfenac and flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye.

Abstract: The present invention relates to an organopolysiloxane elastomer having a silicon-bonded sugar alcohol-modified group and having a crosslinked three-dimensional network structure comprising a carbon-silicon bond in the crosslinking portion. The organomodified organopolysiloxane elastomer of the present invention has, for example, affinity with various oil agents, has excellent viscosity-improving characteristics, gelification characteristics, and emulsification characteristics, imparts excellent tactile sensation—in particular, an excellent tactile sensation characterized by smoothness with a velvet-like thickness—and imparts an excellent sensation during use.

Abstract: Condoms having an elastomeric layer and coating containing an anhydrous warming lubricant and at least one or more ingredients dispersed therein, the coating being disposed on one or both surfaces are provided. The ingredients disposed on the elastomeric layer can be solid particles or encapsulated ingredients that are insoluble in the anhydrous warming lubricant and soluble in water. Methods of producing and using these condoms are also provided.

Abstract: A cosmetic composition containing at least one block copolymer having a hard segment and a soft segment, at least one tackifier component, at least one solvent, at least one gelling agent, and optionally, at least one colorant, and wherein the at least one hard segment has a Tg value of 50° C. or more, and the at least one soft segment has a Tg value of 20° C. or less, and the at least one solvent, or solvent mixture, is capable of solubilizing either the at least one hard segment or the at least one soft segment, or both the hard and the soft segments.

Abstract: The invention relates to a composition in the form of a water-in-oil emulsion comprising an aqueous phase dispersed in an oily phase and containing: a) at least one fatty acid ester of a polyol; and b) at least one hydrophobically modified polysaccharide chosen from inulins, celluloses and derivatives thereof, starches and agars, and mixtures thereof. In particular, the fatty acid ester of a polyol is polyglyceryl-4 diisostearate/polyhydroxystearate/-sebacate. It also relates to a process for caring for, making up and/or removing makeup from the skin, including the scalp, the hair and the lips, comprising the topical application of such a composition to the skin, the scalp or the lips.

Abstract: The present invention relates to a cosmetic composition comprising: (a) one or more antidandruff agents, and (b) one or more amphoteric polymers comprising a repetition of: (i) one or more units derived from a monomer of (meth)acrylamide type, (ii) one or more units derived from a monomer of (meth)acrylamidoalkyltrialkylammonium type, (iii) one or more units derived from an acidic monomer of (meth)acrylic acid type. The invention also relates to a cosmetic process for treating keratin fibres using such a composition, and to a cosmetic use for facilitating the styling and/or for improving the suppleness, smoothness and/or disentangling of the hair.

Abstract: The present invention relates to an organopolysiloxane elastomer having a group having a siloxane dendron structure bonded to a silicon atom, and having a crosslinked structure that includes a carbon-silicon bond in the crosslinking portion, and relates to a glycerin derivative-modified organopolysiloxane elastomer having a siloxane dendron structure bonded to a silicon atom and a hydrophilic group bonded to a different silicon atom from the silicon atom, and having a crosslinked structure that includes a carbon-silicon bond in the crosslinking portion.

Abstract: The invention relates to a composition in the form of an oil-in-water emulsion comprising, in a physiologically acceptable medium: i) at least 0.005% by weight, preferably at least 0.01% by weight, relative to the total weight of the composition, of at least one inulin modified with hydrophobic chains, and ii) at least 0.01% by weight, preferably at least 0.05% by weight, of active substance relative to the total weight of the composition, of at least one hydrophilic acrylic polymer selected from the at least partially neutralized, crosslinked acrylic homopolymers or copolymers, the polyacrylamidomethyl-propanesulphonic acid (AMPS) homopolymers and mixtures thereof. It also relates to a cosmetic method employing said composition.

Abstract: An object is to provide an emulsified cosmetic composition which can impart satisfactory taut feeling and yet is free of stickiness, by incorporating polyvinyl alcohol into a soap-based emulsified cosmetic composition. The present invention relates to an emulsified cosmetic composition comprising: (a) polyvinyl alcohol: 0.01% to 1% by mass; (b) a polyethylene glycol having a molecular weight of 15,000 to 25,000: 0.01% to 5% by mass; (c) a higher fatty acid; and (d) a neutralizing agent.

Abstract: The present invention is directed to a composition containing: (a) at least one tackifier component having a glass transition temperature (Tg) of greater than about 20° C.; (b) at least one film former chosen from a propylphenylsilsesquioxane resin having a molecular weight of from about 2,000 to about 30,000 and comprising at least about 70 mole % propyl siloxy units and at most about 30 mole % phenyl siloxy units, and a propylsilsesquioxane wax substituted with alkyl units having at least 30 carbons; (c) a liquid fatty phase comprising at least one volatile hydrocarbon compound; (d) at least one colorant; (e) optionally, water; and (f) optionally, at least one emulsifier. Also disclosed is a method of making up keratinous substrates involving applying the above composition onto the keratinous substrates.

Abstract: Novel ampholytic ter-polymers comprising at least an ethylenically unsaturated cationic monomer, a monomer containing a carboxylic acid or sulfonic acid group and diallyamine or derivative are claimed. Further, the ter-polymers may be used in personal care or personal washing compositions optionally in the presence of conditioning agents such as silicone, fatty amines, fatty amine oxides and fatty quaternaries and/or various benefit agents. The ter-polymer compositions are especially useful in the treatment of keratin-containing substrates. Keratin substrates include, but are not limited to, animal and human hair, skin and nails.

Abstract: In a fragrance and/or aroma composition for the targeted release of fragrances and/or aromas in the form of a solid lipid nanoparticle (SLN) dispersion, in which lipid-based nanoparticles are present which are stabilized by an emulsifier monolayer, one or more membrane layers or other auxiliaries, the fragrances and/or aromas are included in the nanoparticles and/or in the emulsifier monolayer or the membrane layers.

Abstract: A method may include treating pain, shock, and/or inflammatory conditions in a subject. A method may include using a therapeutically effective amount of an antibody, a lipoxygenase inhibitor, a cytochrome P-450 enzyme inhibitor, and/or an antioxidant configurable to at least partially treat pain, shock, and/or inflammatory conditions in a subject. A method of treating pain, shock, and/or inflammatory conditions in a subject may include inactivating or preventing at least one linoleic acid metabolite to treat certain conditions (e.g., pain, shock, and/or inflammation).

Abstract: The present invention relates to a method of easing childbirth using a composition having a lubricant effect for use in particular during human vaginal delivery. The methods comprise applying a bioadhesive composition comprising (a) a polyacrylic acid, (b) a water-soluble thickener and (c) a humectant and (d) optionally water.

Abstract: The present invention relates to a diblock or triblock polymer of AB, ABA or BAB structure, comprising at least one block A which comprises isobutyl acrylate and acrylic acid. The invention also relates to a cosmetic composition comprising, in a cosmetically acceptable medium, at least one such polymer, and also to a treatment process using it.

Abstract: The invention provides skin protecting and penetrating, easy-to-administer base and active agent-containing compositions, such as those including hydrocortisone, for treating the skin of mammals for different dermatologic disorders. This is effected by topically administering effective amounts of the compositions thereto in forms that address the skin and mucosa of the mouth and lips, and the rest of the body. Additionally, an optional flavoring addition to these products affords significantly better tasting, and less bitter, compositions, allowing a more pleasant experience and better compliance by patients. The compositions include a unique formulation of FANCOL VB, Natunola Castor 1023, Finsolv TN, bees wax and, optionally, one or a plurality of plant or plant seed oils, fatty alcohols, fats and flavorings, in desirable weight percents thereof, in various forms, and preferably in a form of a solid roll-on stick in a variety of sizes and of a jar or pot.

Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.

Abstract: The present invention relates to stable fixed dose topical formulations comprising an antiacne agent and an antibiotic, which exhibit storage stability at a temperature of about 40° C. and relative humidity of about 75% for a period of at least 3 months. Particularly, the present invention relates to stable fixed dose topical formulations comprising therapeutically effective amounts of (a) adapalene-containing microspheres and (b) clindamycin, a process for their preparation thereof and their use for the treatment of acne.

Abstract: The invention describes DOPA functionalized, branched, polyalkylene oxide materials that are useful as adhesives.

Abstract: A cosmetic composition containing at least one block copolymer having at least one hard segment and at least one soft segment, at least one tackifier component, at least one solvent capable of solubilizing the soft segment, and optionally, at least one colorant, and wherein the at least one hard segment has a Tg of about 50° C. or more and the at least one soft segment has a Tg value of about 20° C. or less.

Abstract: A cosmetic composition containing at least one block copolymer having at least one hard segment and at least one soft segment, at least one tackifier component, a solvent mixture, and optionally, at least one colorant, and wherein the at least one hard segment has a Tg value of 50° C. or more, the at least one soft segment has a Tg value of 20° C. or less, and wherein the solvent mixture contains at least one solvent capable of solubilizing the at least one hard segment, and at least one solvent capable of solubilizing the at least one soft segment.

Abstract: A cosmetic composition containing at least one block copolymer having at least one hard segment and at least one soft segment, at least one tackifier component, at least one solvent capable of solubilizing the at least one hard segment, and optionally, at least one colorant, and wherein the at least one hard segment has a Tg value of about 50° C. or more and the at least one soft segment has a Tg value of about 20° C. or less.

Abstract: Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross-linkable component to form a porous matrix having interstices, and combining the porous matrix with a hydrogel-forming component to fill at least some of the interstices. The compositions exhibit minimal swelling properties.

Abstract: This invention relates to novel compositions and methods of use by which the compositions of this invention are applied topically to one or more body parts of at least two individuals who bring said body parts into contact with the other individual and, when said body parts come into contact with each other, permit the formulations to interact and thereby achieve an unexpected sensation to each individual.

Abstract: The present invention relates to a polyurea system encompassing as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which can in particular have a number average molecular weight of ?400 g/mol and an average OH functionality of 2 to 6, as component B) amino-functional compounds of general formula (I) in which X is an organic residue comprising a tertiary amino function, having no Zerewitinoff active hydrogen, R1 is a CH2—COOR3 residue, in which R3 is an organic residue having no Zerewitinoff active hydrogen, a linear or branched C1 to C4 alkyl residue, a cyclopentyl or cyclohexyl residue or H, R2 is an organic residue having no Zerewitinoff active hydrogen, n is an integer ?2 or ?3, in particular for closing, binding, bonding or covering cell tissue, and to a metering system for the polyurea system according to the invention.

Abstract: Aqueous polymer solutions are described which have been stabilized with a preservative mixture of 0.01 to 0.2% by weight of ethylhexylglycerol, 0.001 to 0.01% by weight of 2-methylisothiazolinone and 0.05 to 0.5% by weight of phenoxyethanol. The stabilized polymer solutions are suitable for cosmetic preparations, such as skincare and hair care compositions, products of decorative cosmetics and cosmetic cleaning products.

Abstract: The feel of skin and hair and the manageability of hair exposed to recreational water is improved by the addition of select organic polymers, e.g., charged organic polymers such as cationic organic polymers containing multiple charges. In one embodiment, excellent results are achieved when the added organic polymer(s) include polymeric quaternary ammonium compounds such as poly-DADMAC. The cationic organic polymers of the invention do not interfere with the activity of other recreational water treatments such as halogen releasing compounds and do not decompose due to the presence of halogen releasing water sanitizers, generate a detectable odor or impart noticeable color to the recreational water.

Abstract: External preparations for treatment of painful skin wound having an analgesic activity which comprises acetylsalicylic acid or its pharmacologically acceptable salt as an active ingredient.

Abstract: The invention relates to a composition comprising at least one hyperbranched polyol having at least two hydroxyl groups and at least one reaction product of at least one oil-soluble high carbon polar modified polymer and at least one polyamine.

Abstract: The present invention relates to cleaning composition, preferably a laundry detergent composition, comprising a foam control composition comprising a hydrophobically modified cationic polymer, as well as processes for making and method of using such compositions. The composition of the present invention provides for enhanced suds removal during the rinse cycle with minimal or nil impact on suds volume during the wash cycle.

Abstract: The present invention provides a water-in-oil emulsion cosmetic that is excellent in the resilient and supple (in other words, firm and tensional) feels and also excellent in the moisturizing effect and feeling in use. The water-in-oil emulsion cosmetic of the present invention is characterized by comprising the following (A) to (D): (A) 0.5 to 10 mass % of hydrogenated polyisobutene (B) an oil containing (b1) (b1) a volatile oil of low compatibility with (A) (C) an emulsifying agent and (D) 60 to 90 mass % of an aqueous component, wherein the percentage of component (b1) is 45 to 85% with respect to component (A) and component (B).