Anti-infective Patents (Class 424/78.07)
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Patent number: 7544363Abstract: The present invention discloses compositions derived from an isolated Bacillus species spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. The present invention also discloses methods of treatment and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, by topical application of therapeutic compositions which are comprised, in part, of isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain.Type: GrantFiled: October 12, 2007Date of Patent: June 9, 2009Assignee: Ganeden Biotech, Inc.Inventor: Sean Farmer
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Patent number: 7541045Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.Type: GrantFiled: September 17, 2004Date of Patent: June 2, 2009Assignee: University of ArkansasInventors: Cesar Compadre, Philip Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg
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Patent number: 7541042Abstract: The present invention discloses compositions derived from an isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. The present invention also discloses methods of treatment and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, by topical application of therapeutic compositions which are comprised, in part, of isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain.Type: GrantFiled: June 14, 2005Date of Patent: June 2, 2009Assignee: Ganeden Biotech, Inc.Inventor: Sean Farmer
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Publication number: 20090110657Abstract: Provided are compositions which are suitable for topical application to mammalian skin for cleansing and anti-microbial properties. In one embodiment, the compositions include an ester of polyalkylene glycol monoazelate monolaurate. It is postulated that bacteria on or in the skin may cleave the ester linkage of a compound according to the present disclosure that is applied to the skin, which causes liberation of the acid moiety from the ester, which acid moiety then inhibits or kills the bacterium. Compositions according to the present disclosure may comprise skin creams, soaps, shampoos and lotions, and are especially effective in treating acne and acne-like skin ebullitions.Type: ApplicationFiled: October 31, 2007Publication date: April 30, 2009Inventor: Christopher J. Whewell
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Publication number: 20090098081Abstract: A system for providing a method of sealing skin with a film forming polymer is provided. The system includes providing an at least two part applicator containing a sealant composition in one or more frangible containers, providing instructions for using the applicator associated therewith, where the method including moving at least one of said applicator parts from a first position to a second position and applying said sealant to skin. The composition has film former, a plasticizer and 3000 to 10000 ppm of a dye that changes color when is undergoes a phase change. The color change is visible to a human eye under normal light conditions. changing dyes may be used to indicate that the composition has dried. The dyes change color in response to the phase change, i.e., drying of the film former.Type: ApplicationFiled: October 12, 2007Publication date: April 16, 2009Inventors: John Gavin MacDonald, Molly K. Smith, Ilona F. Weart, Phillip A. Schorr
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Publication number: 20090092576Abstract: A fungus treatment composition used to deliver active drugs trans-nail as well as a method for producing the fungus treatment composition, which may contain up to 50% additive ingredients. Preferred embodiments of the invention may include fungus treatment compositions which provide high nail penetrating power, which have antifungal agents, which have antifungal essential oils, which have optimum drying and barrier properties, which have pharmaceutically elegant properties, or most preferably an embodiment having a total combination thereof.Type: ApplicationFiled: October 6, 2008Publication date: April 9, 2009Applicant: Humco Holding Group, Inc.Inventor: John Olin Trimble
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Publication number: 20090035249Abstract: A method of inhibiting proliferation of Escherichia coli at an anatomical site on tissue of a human or animal body is described. The method comprises applying to the site a bacteriostatically effective amount of an aminated polyether.Type: ApplicationFiled: July 28, 2008Publication date: February 5, 2009Inventors: Sujata K. Bhatia, Henry Keith Chenault
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Publication number: 20090035248Abstract: The invention provides polyanhydrides that degrade in less than 60 hours following topical administration to deliver biologically active compounds.Type: ApplicationFiled: May 23, 2006Publication date: February 5, 2009Applicant: Rutgers, The State University of New JerseyInventors: Kathryn E. Uhrich, Young Mi Kim
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Patent number: 7468194Abstract: Disclosed in certain embodiments is a method of treating infections of an interior part of the human or animal body, comprising administering to said interior body part, a pharmaceutical preparation comprising a particulate carrier and an effective amount of an agent selected from the group consisting of an antiseptic agent, a wound-healing promoting agent and a combination thereof, to treat an infection at said interior body part.Type: GrantFiled: May 25, 2000Date of Patent: December 23, 2008Assignee: Euro-Celtique, S.A.Inventors: Wolfgang Fleischer, Karen Reimer
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Publication number: 20080253984Abstract: A method for treating onychomycosis and skin conditions such as urushiol-induced allergic contact dermatitis comprises coating the affected nail or skin with a solution comprising an at least a primary diamine with modified diphenylmethane diisocyanates and a carrier solvent/reactant.Type: ApplicationFiled: April 15, 2008Publication date: October 16, 2008Inventors: Stephen G. Kovacs, Jerry Chesson
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Patent number: 7419657Abstract: The present invention relates to the identification of lipid oxidizing abzymes as a key pathogenic factor in atherosclerotic disorders. Methods and means for the reduction of abzyme mediated lipid oxidation in the vascular system are provided as therapeutic approaches for the treatment of atherosclerotic disorders. Methods are provide for determining the efficacy of treatment.Type: GrantFiled: August 22, 2002Date of Patent: September 2, 2008Assignee: Cambridge Theranostics Ltd.Inventor: Ivan Petyaev
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Publication number: 20080175811Abstract: Composition for application to skin comprising a biocide or combination of biocides (such as chlorhexidine, halogenated phenols, quaternary ammonium compounds; povidone-iodine; zinc pyridinethione; alcohols etc) and at least one transcutaneous vehicle (for example alkyl methyl sulfoxides, alkyl pyrrolidones, glycols, glycol ethers and glycol esters) effective to convey the biocide to a sub epidermal “resident” micro-organism. Also a method for preparing a patient for surgery comprising the step of treating an area of the patient's skin at, and in the surrounding the vicinity of, the site of an intended surgical incision with a composition effective to kill more than 93% of both “transient” and “resident” micro-organisms.Type: ApplicationFiled: April 28, 2006Publication date: July 24, 2008Applicant: Novapharm Research (Australia) Pty Ltd.Inventor: Steven Kritzler
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Publication number: 20080175810Abstract: This invention relates to topical compositions in the form of dispersion gels formed by dispersing into an aqueous gel phase a substantially homogenous organic solution containing at least one active ingredient and at least one organic polymer solubilized in an organic carrier. The organic carrier comprises at least one water-miscible organic solvent and at least one water-immiscible organic solvent. The polymer is selected to affect efficacy of the compositions. The compositions are essentially free of surface-active substances and have favorable galenic properties.Type: ApplicationFiled: January 22, 2007Publication date: July 24, 2008Inventor: Jerry Zhang
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Patent number: 7393522Abstract: Described herein is a physiologically-balanced, acidic solution. Typically the solution is prepared by a chemical reactions or by the electrolysis of a solution comprising a mixture of an inorganic salt to form a physiologically balanced solution. This invention also relates to methods for use of the solutions, including a specialized bandage which may be used in combination with the solutions, or optionally with other topically applied materials. A mixture of inorganic salts and, optionally minerals, is used in order to mimic the electrolyte concentration and mixture of body fluid in an isotonic state. The solution typically comprises of one halide salt of lithium, sodium, potassium, calcium, and other cations. Typically the halide is fluoride, chloride, bromide, or iodide, and most typically chloride.Type: GrantFiled: September 3, 2003Date of Patent: July 1, 2008Assignee: NovaBay Pharmaceuticals, Inc.Inventors: Ramin Najafi, Lu Wang, Mansour Bassiri, Jane Yang
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Publication number: 20080152614Abstract: A method for treatment or prevention of skin lesions, e.g., blisters, comprising: a) applying a liquid polymerizable foundation composition to a selected location on skin, e.g., an existing lesion or an area to be protected from formation of a lesion, b) at least partially polymerizing the foundation composition in situ to form a foundation layer, and c) applying a liquid cap formulation to the foundation layer. Also a kit for carrying out such method.Type: ApplicationFiled: December 22, 2006Publication date: June 26, 2008Inventor: Wayne K. Dunshee
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Patent number: 7374747Abstract: The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized contained comprising a quick-breaking alcoholic foaming agent, such that when the composition is released, i.e., dispensed, from the pressurized container, a quick-breaking temperature sensitive foam is formed. In addition, the present invention provides various aspects related to such compositions, including methods for modulating a foam characteristic, methods for improving the shelf-life of a pharmaceutically active compound, methods for the percutaneous treatment of various diseases, infections, and illnesses, and methods for evaluating foam characteristics.Type: GrantFiled: August 9, 2006Date of Patent: May 20, 2008Assignee: Stiefel Research Australia, Pty Ltd.Inventors: Albert Zorko Abram, Barry Thomas Hunt
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Patent number: 7332470Abstract: The use of collectins and/or surfactant proteins for the treatment and prevention of ocular disease.Type: GrantFiled: April 14, 2004Date of Patent: February 19, 2008Assignees: The Regents of the University of California, The Research Foundation of State University of New YorkInventors: Suzanne Fleiszig, David J. Evans, Robert Sack
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Patent number: 7288622Abstract: A composition is provided to heal burns, wounds and other skin traumas of mammals. The composition is useful to treat sepsis and to improve skin formation as well. The composition comprises an antimicrobial peptide having amino acid sequence FAKKFAKKFKKFAKKFAKFAFAF.Type: GrantFiled: September 19, 2006Date of Patent: October 30, 2007Assignee: Issar Pharmaceuticals Pvt LtdInventors: Jesse Jaynes, Ramakrishnareddy Isanaka
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Patent number: 7238680Abstract: A method of treating a non-human dermatological disorder, wherein the method comprises topically administering to a non-human dermatological disorder a therapeutically effective amount of a topical composition containing: (1) an active component comprising at least one salicylate derivative; and (2) at least one pharmaceutically acceptable solubilizer.Type: GrantFiled: June 3, 2002Date of Patent: July 3, 2007Inventor: Steven E. Rosen
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Patent number: 7223387Abstract: A topical composition comprising an antiinflammatory glucocorticoid and a nucleoside analogue antiviral agent in a pharmaceutical carrier characterized in that the carrier comprises about 15 to about 25 weight % propylene glycol and about 10 to about 25 weight percent isopropyl C12–C22 alkanoic ester. The compositions have utility in the treatment or prophylaxis of herpesvirus infections and exhibit superior antiviral and therapeutic efficacy and an improved shelf life.Type: GrantFiled: December 30, 2002Date of Patent: May 29, 2007Assignee: Medivir ABInventor: Gunilla Lekare
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Patent number: 7192601Abstract: Germicidal compositions with enhanced activity towards killing microbiological spores and vetgetative cells comprising certain quaternary ammonium compounds (QACs), phenolic compounds, monohydric alcohols, hydrogen peroxide, iodine, triclocarban, triclosan or combinations thereof with one or more spore coat opening agents. The invention also provides for the application of the germicidal compositions to animate and inanimate surfaces to help kill germs and protect against the risk of infection from bacteria, molds, yeasts, fungi, viruses, and microbiological spores.Type: GrantFiled: January 16, 2003Date of Patent: March 20, 2007Inventor: Edward B. Walker
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Patent number: 7169402Abstract: The invention provides an antimicrobial and antiviral polymeric material, having microscopic particles of ionic copper encapsulated therein and protruding from surfaces thereof.Type: GrantFiled: April 1, 2001Date of Patent: January 30, 2007Assignee: The Cupron CorporationInventor: Jeffrey Gabbay
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Patent number: 7147873Abstract: Antiseptic compositions, as well as methods of making and using, wherein the compositions include: an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least about 0.25 wt-%; a hydroxycarboxylic acid buffer in an amount of at least about 5 wt-%; water; and an optionally substantive film-forming polymer.Type: GrantFiled: January 16, 2002Date of Patent: December 12, 2006Assignee: 3M Innovative Properties CompanyInventors: Matthew T. Scholz, Danli Wang, Triet M. Lu, Dong-Wei Zhu
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Patent number: 7141237Abstract: The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized container comprising a quick-breaking alcoholic foaming agent, such that when the composition is released, i.e., dispensed, from the pressurized container, a quick-breaking temperature sensitive foam is formed. In addition, the present invention provides various aspects related to such compositions, including methods for modulating a foam characteristic, methods for improving the shelf-life of a pharmaceutically active compound, methods for the percutaneous treatment of various diseases, infections, and illnesses, and methods for evaluating foam characteristics.Type: GrantFiled: January 23, 2004Date of Patent: November 28, 2006Assignee: Connetics Australia Pty Ltd.Inventors: Albert Zorko Abram, Barry Thomas Hunt
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Patent number: 7081246Abstract: A hydroalcoholic lotion is disclosed which comprises (a) a lower alcohol and water in a weight ratio of about 35:65 to 100:0, and (b) between at least 0.5% and 8% by weight thickener system comprised of at least one emulsifier present in at least 0.05% by weight wherein the composition in a polymer free state has a viscosity of at least 4,000 centipoise at 23 degrees C. and wherein the emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The hydroalcoholic composition is useful as a hand preparation such as a lotion or as a presurgical scrub replacement.Type: GrantFiled: September 4, 2003Date of Patent: July 25, 2006Assignee: 3M Innovative Properties CompanyInventors: Robert A. Asmus, Matthew T. Scholz, Jill R. Charpentier
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Patent number: 7078050Abstract: A white cream bacteriostat and fungicide capable of serving as a vehicle for additional medicaments. Also disclosed is a method for blending the ingredients, some of which are not readily compatible with each other.Type: GrantFiled: October 25, 2004Date of Patent: July 18, 2006Inventor: Normajean Fusco
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Patent number: 7045552Abstract: Provided is a pharmaceutical composition comprising a solution comprised of synthetic peptide in a final concentration of not less than 70 mg/ml in admixture with a polyol; wherein the synthetic peptide is an HIV fusion inhibitor, and wherein the polyol is in a final concentration of no less than 5 weight % and no more than 75 weight % of the pharmaceutical composition. Also provided is a synthetic peptide-containing pharmaceutical composition as a unit dose comprising an aqueous formulation comprised of synthetic peptide in a final concentration of not less than 70 mg/ml in admixture with a polyol; wherein the synthetic peptide is an HIV fusion inhibitor, and wherein the polyol is in a final concentration of no less than 5 weight % and no more than 75 weight % of the pharmaceutical composition. Further provided is a method of treating HIV infection by administering to an HIV-infected individual a pharmaceutical composition according to the present invention.Type: GrantFiled: September 16, 2003Date of Patent: May 16, 2006Assignee: Trimeris, Inc.Inventors: David Heilman, Jie Di, Brian Bray
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Patent number: 7037527Abstract: The invention features a method of treating polyester material to generate functional carboxylic acid and amine groups. These functional groups can be used as sites for covalent bond formation to attach chemical or biological moieties. This bifunctionalized polyester polymer can be used in any medical application in which biocompatible polymers are used.Type: GrantFiled: January 27, 2003Date of Patent: May 2, 2006Assignees: University of Rhode Island, Beth Israel Deaconess Medical Center, BioMod SurfacesInventors: Martin J. Bide, Matthew D. Phaneuf, William C. Quist, Donald J. Dempsey, Frank W. LoGerfo
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Patent number: 7005031Abstract: A pressure sensitive adhesive composition is provided that includes a pressure sensitive adhesive polymer. The polymer includes: at least one copolymerized monoethylenically unsaturated (meth)acrylic acid ester monomer, wherein the (meth)acrylic acid ester monomer, when homopolymerized, has a Tg of less than about 25° C.; at least one copolymerized monoethylenically unsaturated reinforcing monomer, wherein the reinforcing monomer, when homopolymerized, has a Tg of at least about 25° C.; covalently bonded quarternary ammonium functionality; and, optionally, at least one copolymerized monoethylenically unsaturated poly(alkylene oxide) monomer. The composition optionally further includes at least one nonreactive poly(alkylene oxide) polymer and/or at least one antimicrobial agent.Type: GrantFiled: January 16, 2002Date of Patent: February 28, 2006Assignee: 3M Innovative Properties CompanyInventors: Donald H. Lucast, Dong-Wei Zhu
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Patent number: 6998131Abstract: In particular this invention provides for spot-on compositions for the treatment or prophylaxis of parasite infestations in mammals or birds which comprise: (1) a composition comprising (A) an effective amount of a 1-phenylpyrazole derivative; and (B) an effective amount of emamectin; (2) an acceptable liquid carrier vehicle; and (3) optionally, a crystallization inhibitor. The invention also provides for a method of treating parasitic infestations or for the prophylaxis of parasite infestations in mammals or birds which comprises topically applying to said mammal treating parasitic infestations or for the prophylaxis of parasite infestations in mammals or birds which comprises topically applying to said mammal or bird an effective amount of a composition according to the present invention.Type: GrantFiled: October 24, 2002Date of Patent: February 14, 2006Assignee: Merial LimitedInventors: Mark D. Soll, Albert Boeckh
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Patent number: 6994863Abstract: A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1–25 percent of a solidifying agent and 75–99 percent of a hydrophobic solvent, by weight, wherein at least one of them has therapeutic or cosmetic benefits, in the presence or absence of a biologically active substance.Type: GrantFiled: March 19, 2003Date of Patent: February 7, 2006Assignee: Foamix Ltd.Inventors: Meir Eini, Dov Tamarkin
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Patent number: 6974585Abstract: Disclosed are methods and formulations for the treatment or prevention of infections on mammalian tissues such as skin. Specifically, the methods of this invention involve the in situ formation of a polymeric cyanoacrylate film containing mixed antibiotics over mammalian tissue.Type: GrantFiled: July 31, 2002Date of Patent: December 13, 2005Assignee: MedLogic Global LimitedInventor: Ian N. Askill
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Patent number: 6964782Abstract: Disclosed are several preferred embodiments of hydrogen peroxide which are packaged with ease of use and extended shelf-life in mind. The embodiments include foam, mist, gel, and disposable towelette forms of H2O2. Optional ingredients of topical pain relievers and skin protectants are also disclosed, as are their methods of use.Type: GrantFiled: July 7, 2003Date of Patent: November 15, 2005Assignee: Tec Labs, Inc.Inventors: Robert Lee Smith, Steven Dale Smith, Wendy S. Langley, John Mark Christensen, Vernon W. Smith
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Patent number: 6962712Abstract: Cosmetic or dermatological composition characterized in that it comprises a combination of an elastase inhibitor of the N-acylaminoamide family and at least one antifungal agent or at least one antibacterial agent.Type: GrantFiled: June 26, 2002Date of Patent: November 8, 2005Assignee: L'OrealInventors: Lionel Breton, Yann Mahe
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Patent number: 6905692Abstract: The present invention discloses compositions derived from an isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. The present invention also discloses methods of treatment and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, by topical application of therapeutic compositions which are comprised, in part, of isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain.Type: GrantFiled: June 28, 2002Date of Patent: June 14, 2005Assignee: Ganeden Biotech, Inc.Inventor: Sean Farmer
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Patent number: 6884423Abstract: The invention includes antibiotic pharmaceutical compositions comprising eukaryotic histone H1 protein and methods of using eukaryotic histone H1 protein to kill or to inhibit the growth of microorganisms, including, but not limited to, human pathogenic bacteria. The invention further includes a eukaryotic histone H1-containing animal feed and methods of improving growth of an animal by supplying the feed to the animal. The invention still further includes a kit comprising a eukaryotic histone H1-containing antibiotic pharmaceutical composition and an instructional material which describes the use of the composition. In addition, the invention includes a vaccine comprising a eukaryotic histone H1 protein and a method of vaccinating an animal using the vaccine.Type: GrantFiled: August 9, 2000Date of Patent: April 26, 2005Assignees: Symbiotec GmbH, Philadelphia Health and Education CorporationInventors: Reiner Class, Michael Zeppezauer
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Patent number: 6824763Abstract: A body powder is disclosed. The body powder includes a topical anti-fungal agent in combination with at least two excipients. One excipient is a boron nitride particulate material coated with a silicone compound. The other excipient is a fragrance molecularly entrapped within a cyclodextrin compound.Type: GrantFiled: May 30, 2002Date of Patent: November 30, 2004Assignee: Kimberly-Clark Worldwide, Inc.Inventor: JoAnn Adele Brooks
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Patent number: 6749869Abstract: The mastitis control teat dip composition of the invention provides rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The compositions of the invention are made by combining an aqueous thickened liquid composition containing the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite. The materials can be combined, blended into a smooth viscous material and can be immediately contacted with the target animals. The compositions of the invention provide rapid initial kill, consistent long term kill and chemical and rheological stability.Type: GrantFiled: September 26, 1997Date of Patent: June 15, 2004Assignee: EcolabInventors: Francis L. Richter, Cathy M. Paquette, Richard K. Staub
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Patent number: 6746667Abstract: A method of treating or preventing tinea pedis, commonly known as Athlete's Foot, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to tinea pedis, optionally with at least one of an additional anti-fungal agent or a foot care additive, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.Type: GrantFiled: July 5, 2001Date of Patent: June 8, 2004Assignee: Closure Medical CorporationInventors: Ibraheem Badejo, Daniel L. Hedgpeth, Upvan Narang, William S. C. Nicholson, Andres Rivera, Mary Jo S. Rivera, Anthony Sherbondy, Gabriel N. Szabo
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Patent number: 6733751Abstract: An animal-derived lipid is disclosed that is useful as a carrying agent for anti-microbial formulations. Pharmaceutical and other preparations including Emu Oil are also described as profoundly useful components in anti-bacterial, anti-fungal, and anti-viral treatments. This lipid material is extracted from the Emu (Dromais Novae-Hollandiae), an indigenous bird of Australia and New Zealand. The present invention also discloses therapeutic compositions comprising Emu Oil in combination with an extracellular product of Bacillus coagulans or Pseudomonas lindbergii strain, comprising a supernatant or filtrate of said culture suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. Additionally, the aforementioned therapeutic composition may also include an anti-microbial, anti-mycotic, and/or anti-viral agent.Type: GrantFiled: March 10, 2003Date of Patent: May 11, 2004Assignee: Ganeden Biotech, Inc.Inventor: Sean Farmer
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Patent number: 6723689Abstract: An antimicrobial composition comprising an alcohol in an amount from about 60 to about 95 weight percent of the total composition, a preservative, a cationic cellulose polymer thickening agent, a moisturizer and/or, a cationic emulsifier, and water in an amount from about 6 to about 30 weight percent. The skin disinfecting formulation will not irritate, dry or crack the skin and will provide antimicrobial effectiveness to the skin.Type: GrantFiled: January 8, 2003Date of Patent: April 20, 2004Assignee: Becton Dickinson and CompanyInventors: Minh Quang Hoang, Donald Edward Hunt
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Patent number: 6719988Abstract: An antiseptic composition useful in destroying the infectivity of infectious proteins such as prions is disclosed. The antiseptic composition is preferably maintained at a pH of 4.0 or less which allows for an environment under which the active component destroys infectivity. The composition may be added to blood, blood products, collagen, tissues and organs prior to transplantation. The composition also may be added to livestock feed to denature any prions in the livestock. Methods of denaturing infectious proteins are also disclosed.Type: GrantFiled: July 11, 2001Date of Patent: April 13, 2004Assignee: The Regents of the University of CaliforniaInventors: Stanley B. Prusiner, Surachai Supattapone
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Patent number: 6699510Abstract: The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The indicator aspect provides ease of visually detecting the material on the animal skin and can indicate efficacy of the material. The compositions of the invention are made by combining an aqueous liquid composition containing the visual indicator combined with the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite.Type: GrantFiled: August 19, 2002Date of Patent: March 2, 2004Assignee: Ecolab Inc.Inventors: David D. McSherry, Francis L. Richter
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Patent number: 6696041Abstract: The invention relates generally to a method which utilizes iodine as a broad spectrum microbicide wherein the active agent may be applied in nasal passages in the manner of a decongestant type nose spray. The spray is intended particularly for human use. It is to be applied in the event of known or suspected exposure of the individual to common cold virus, flu, or other infective microbial agents including for example, bacteria, viruses, rickettsia, and even mold and fungus. The active agent is based on an iodine solution and may also contain one or more of the following: sodium hypochlorite solution, or a solution of chlorine or hypochlorites plus a salt of chloride, bromide or iodide. Alternatively, the solution may further contain iodine and a bromine solution, or a solution of iodine, bromine plus a salt of chloride, bromide or iodide such as sodium chloride, zinc chloride, sodium bromide, zinc bromide, sodium iodide or zinc iodide.Type: GrantFiled: May 6, 2002Date of Patent: February 24, 2004Inventor: Richard L. Hansen
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Publication number: 20040033208Abstract: Antimicrobial compositions containing one or more topically active antibiotics (e.g., Natamycin) and one or more amidoamines are described. The amidoamines enhance or supplement the antimicrobial activity of natamycin or other topically active antibiotics. The compositions are particularly useful in treating or preventing fungal infections of the eye, ear, nose and throat, as well as sterilizing these tissues prior to surgery or other medical procedures.Type: ApplicationFiled: May 22, 2003Publication date: February 19, 2004Inventors: Gerald D. Cagle, Barry A. Schlech, Joseph W. Hiddene, G. Michael Wall
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Patent number: 6645510Abstract: A composition capable of forming a film that ionically bonds to the skin comprising one or more active agents, a nonionic or substantially nonionic first film forming component, one or more cationic surfactant and a liquid carrier.Type: GrantFiled: August 30, 2001Date of Patent: November 11, 2003Assignee: American Medical Research, Inc.Inventors: William S. Coury, Griscom Bettle, Berno I. Pettersson
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Patent number: 6635242Abstract: Microbicidal and spermicidal devices, methods, and compositions containing sodium dodecyl sulfate or related anionic surfactants as active ingredients for the prevention and control of pregnancy and sexually transmitted disease, including conditions caused by non-enveloped viruses such as human papilloma virus.Type: GrantFiled: August 15, 2002Date of Patent: October 21, 2003Assignee: The Pennsylvania State UniversityInventors: Mary K. Howett, John W. Krieder
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Patent number: 6635243Abstract: The present invention can be used in pharmacology specifically in the preparation of interferon-containing compositions, which are capable of conserving their biological activity and can be administrated intranasally, e.g. in the preparation of nasal drops. This invention essentially refers to an antiviral agent in the form of nasal drops that contains a genetically engineered alpha, beta or gamma interferon with a viscosity of (1.1-30.0)* 10 Pascal ·second, a biocompatible polymer and a buffer mixture. The agent may further include an antioxidant, and the ingredients are contained in the following amounts per ml buffer mixture: 1,000 to 5,000 IU of genetically engineered interferon; 0.005 to 0.714 g of biocompatible polymer; and 0.0001 to 0.0008 g of an antioxidant. TRILON B® (disodium salt of EDTA) is used as the antioxidant, whereas polyvinylpyrrolidone and/or polyethylene oxide is (are) used as the biocompatible polymer(s) at polyvinylpyrrolidone/polyethylene oxide ratio of 1:1-50.Type: GrantFiled: December 18, 2001Date of Patent: October 21, 2003Inventors: Petr Jakovlevich Gaponyuk, Elena Alexeevna Markova, Iliya Alexandrovich Markov
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Patent number: 6623729Abstract: The present invention relates to a process of preparing a sustained release micelle by copolymerizing a biodegradable polyester hydrophobic polymer and a hydrophilic polyethylene glycol (PEG) to obtain a block copolymer, reacting the block copolymer with a linker to the hydroxyl group of the block copolymer and conjugating the linker-bound block copolymer to a drug to obtain a micelle monomer, and dispersing the micelle monomer an aqueous solution. The drug-micelle conjugate of the present invention has practical application in anticancer therapy.Type: GrantFiled: July 9, 2001Date of Patent: September 23, 2003Assignee: Korea Advanced Institute of Science and TechnologyInventors: Tae Gwan Park, Hyuk Sang Yoo
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Patent number: RE39298Abstract: This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, antiproliferatives, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Further provided are methods of using the site-specific supplemented tissue sealants, including preparation of a biomaterial.Type: GrantFiled: June 20, 2003Date of Patent: September 19, 2006Assignee: The American National Red CrossInventors: Martin J. MacPhee, William N. Drohan, Gene Liau, Hernan Nunez, Wilson H. Burgess, Thomas Maciag, Manish Singh