Polymer Containing (e.g., Polypeptide, Synthetic Resin, Etc.) Patents (Class 424/9.322)
  • Patent number: 10835604
    Abstract: Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be configured as, or be a component of, brachytherapy spacers and applicators, or radiotherapy fiducial markers. The composition may be combined with marginless radiotherapy, allowing for lower doses of radiation and enhancing the immune response against cancer, including at non-irradiated sites.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: November 17, 2020
    Assignees: Northeastern University, Dana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Wilfred Ngwa, Rajiv Kumar, Gerassimos Makrigiorgos, Srinivas Sridhar, Stephanie Dougan
  • Patent number: 10639372
    Abstract: A medical nanoparticle includes a core, an outer lipid layer, an inner lipid layer, a photosensitizer, and a nucleic acid. The core includes a bio-degradable ionic precipitate (BIP). The inner lipid layer is between the core and the outer lipid layer. The photosensitizer is between the inner lipid layer and the outer lipid layer, and the nucleic acid is at the surface of the core.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: May 5, 2020
    Assignee: CHUNG YUAN CHRISTIAN UNIVERSITY
    Inventors: Leaf Huang, Yih-Chih Hsu, Gang Zheng, Chia-Hsien Yeh
  • Patent number: 10617711
    Abstract: The invention relates to an antitumor composition based on hydrophobized hyaluronan and inorganic nanoparticles stabilized by oleic acid. The hydrophobized hyaluronan in the form of an acylated hyaluronan serves in the composition as a carrier of inorganic nanoparticles. Out of the group of inorganic nanoparticles, the composition may comprise superparamagnetic nanoparticles, nanoparticles of ZnO and moreover, upconversion nanoparticles. Said composition is selectively cytotoxic with respect to both suspension and adherent tumor cell lines, especially with respect to tumor cell lines of colorectum carcinoma and adenocarcinoma, lung carcinoma, hepatocellular carcinoma and breast adenocarcinoma. The highest cytotoxic effects were observed in case of the composition based on an oleyl derivative of hyaluronan with SPIONs. The composition of acylated hyaluronan with SPIONs may also be advantageously used for an in vivo detection of accumulation of the composition in the body, preferably in a tumor or in liver.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: April 14, 2020
    Assignee: Contipro a.s.
    Inventors: Daniela Smejkalova, Kristina Nesporova, Martina Tepla, Jakub Syrovatka, Gloria Huerta-Angeles, Martina Pospisilova, Vit Matuska, Jiri Mrazek, Andrea Galisova, Daniel Jirak, Vladimir Velebny
  • Patent number: 10584191
    Abstract: Techniques regarding a star polymer with light-activated enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a plurality of non-degradable copolymer arms comprising respective first ends and respective second ends. The respective first ends can be crosslinked to form a vinyl polymer core and the respective second ends can have antimicrobial functionality. Further, the polymer can comprise a singlet oxygen generator loaded within the vinyl polymer core. The singlet oxygen generator can generate a singlet oxygen species in response to light.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: March 10, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Mohd Bakri Bakar, James L. Hedrick, Victoria A. Piunova, Andy Theodora Tek
  • Patent number: 10406110
    Abstract: Provided is a nanoparticle-vitreous body-based protein complex, and more particularly, to a composition for inhibiting angiogenesis which includes the complex as an active ingredient, and a composition for preventing or treating an angiogenesis-related disease or a retinal disease. When the nanoparticle-vitreous body-based protein complex according to the subject matter is locally injected into the vitreous body, the complex exhibits significantly excellent binding strength with a vascular endothelial growth factor and thus can inhibit angiogenesis, thus being easily used to prepare a therapeutic agent for preventing, alleviating, or treating retinal and choroidal angiogenesis-related diseases.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: September 10, 2019
    Assignees: Seoul National University R & DB Foundation, Korea Research Institute of Standards and Science
    Inventors: Jeong Hun Kim, Dong Hyun Jo, Tae Geol Lee
  • Patent number: 10145928
    Abstract: An example method for mapping tissue magnetic susceptibility includes acquiring magnetic resonance (MR) data, where the MR data correspond to a subject, determining a magnetic field based on the MR data, determining a relationship between the magnetic field at a given location to the magnetic susceptibility at that location, and performing a convolution operation on the relationship between the magnetic field at the given location to the magnetic susceptibility at that location to obtain a noise property. The method also includes estimating a magnetic susceptibility distribution of the subject based, at least in part, on the noise property, and generating one or more images of the subject based on the estimated susceptibility distribution of the subject.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: December 4, 2018
    Assignee: MedImageMetric LLC
    Inventor: Tian Liu
  • Patent number: 10039843
    Abstract: The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: August 7, 2018
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Chiara Brioschi, Claudia Cabella, Simona Ghiani, Alessandro Maiocchi, Luigi Miragoli, Massimo Visigalli
  • Patent number: 9889212
    Abstract: A preparation method for a magnetic composite for treating and diagnosing cancer. The method may include a step of pyrolyzing a precursor of a magnetic nanoparticle in the presence of a conjugated polymer. The preparation method for a magnetic composite can produce a magnetic composite economically and efficiently because a magnetic composite comprising a magnetic nanoparticle coated with a conjugated polymer can be prepared by a single process.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: February 13, 2018
    Assignee: Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Jae Moon Yang, Jin Suck Suh, Seung Joo Haam, Eu Gene Lee, Yoo Chan Hong, Min Hee Ku, Dan Heo, Seung Yeon Hwang, Yong Min Huh
  • Patent number: 9839694
    Abstract: Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: December 12, 2017
    Assignee: Nitto Denko Corporation
    Inventors: Kwok Yin Tsang, Hao Bai, Yi Jin, Lei Yu
  • Patent number: 9808428
    Abstract: The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: November 7, 2017
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Howard E. Gendelman, Xin-Ming Liu
  • Patent number: 9771275
    Abstract: The present invention relates to a method for preparing uniform metal oxide nanoparticles. According to the preparation method of the present invention, it is possible to maintain the temperature and pressure inside the reactor in a stable and constant manner by removing water generated in the reaction step for forming metal oxide nanoparticles. Thus, the uniformity of nanoparticles formed is increased, and the reproducibility between batches can be increased even in a repeated process and and a large-scale reaction. Therefore, the preparation method of the present invention can be used to synthesize uniform nanoparticles reproducibly in large quantities.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: September 26, 2017
    Assignee: HANWHA CHEMICAL CORPORATION
    Inventors: Ju Young Park, Eung Gyu Kim, Wan Jae Myeong, Bong Sik Jeon, Eun Byul Kwon
  • Patent number: 9725554
    Abstract: The present invention provides a composition comprising an amphiphile and an active ingredient whose solubility in water at 20° C. is not more than 10 g/L, wherein the amphiphile comprises a dendritic polyurea which is joined to at least one linear or comb-type polymer, and the joining is effected via a difunctional linker, if the repeat units of the linear polymer are composed of polymerized alkylene oxide. The invention also relates to an amphiphile comprising a dendritic polyurea and a process for preparing the amphiphile.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: August 8, 2017
    Assignee: BASF SE
    Inventors: Holger Türk, Monika Haberecht, Hiroe Yamada, Bernd Bruchmann, Daniel Schönfelder, Michael Ishaque
  • Patent number: 9492480
    Abstract: In accordance with the present disclosure there are provided iron oxide nanoparticles for use in the treatment of non-infectious inflammatory disorders. Also provided by the present disclosure is a method of treatment of non-infectious inflammatory disorders making use of such particles, pharmaceutical compositions and kits comprising such particles.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: November 15, 2016
    Assignees: RAMOT AT TEL AVIV UNIVERSITY LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD
    Inventors: Jonathan Leor, Tamar Ben-Mordechai, Shimrit Adutler-Lieber, Rimona Margalit, Inbar Elron-Gross, Yifat Glucksam-Galnoy
  • Patent number: 9375400
    Abstract: The compositions and methods of the disclosure particularly target the divalent metal transporter expressed on olfactory nerve terminals to transport divalent cation-coated or cation-containing nanoparticles to all regions of brain. It has been found that such divalent cation-containing nanoparticles, including those nanoparticles comprising manganese have affinity for the metal transport receptor proteins. Although this receptor has particular affinity for manganese, it is contemplated that other divalent ions, including magnesium, calcium, and the like may also be bound to such receptors leading to transport of the nanoparticles into the intracellular cytoplasm. Nanoparticles have been developed, therefore, as vehicles for parenteral delivery of genes, proteins and drugs.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: June 28, 2016
    Assignee: University of South Florida
    Inventors: Juan Sanchez-Ramos, Vasyl Sava, Shijie Song, Shyam S. Mohapatra, Subhra Mohapatra
  • Patent number: 9370490
    Abstract: A method for producing triblock copolymer-coated metallic nanoparticle seeds which increases the size and shape homogeneity of the triblock copolymer-coated metallic nanoparticle seeds. A quantity of triblock copolymer-coated metallic nanoparticle seeds. A method for producing triblock copolymer-coated metallic nanoparticles which increases the size and shape homogeneity of the triblock copolymer-coated metallic nanoparticles. A quantity of triblock copolymer-coated metallic nanoparticles. A method for producing modified metallic nanoparticles which increases the size and shape homogeneity of the modified metallic nanoparticles. A quantity of modified metallic nanoparticles.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: June 21, 2016
    Assignee: Loma Linda University
    Inventors: Ralph S. Kurti, Jr., Christopher C. Perry, Theodore Sabir
  • Patent number: 9352053
    Abstract: An iron oxide particle constituting a Resovist (trademark) absorbs a small quantity of light in a near infrared region and emits a weak photoacoustic signal. According to a particle having a catechol-like compound and iron atoms, the particle having a ratio of the number of moles of the catechol-like compound to the number of moles of the iron atoms of 270/10,000 or more, light absorption in the near infrared region increases and a strong photoacoustic signal can be transmitted.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: May 31, 2016
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Yasuhiko Tabata, Sachiko Yamauchi, Mayuko Kishi, Masato Minami, Mika Yamagata, Satoshi Yuasa, Tetsuya Yano
  • Patent number: 9336605
    Abstract: A medical imaging system (900, 1000, 1100, 1200) for acquiring medical image data (930), the medical imaging system comprising: a tissue treating system (910, 1080, 1180, 1190, 1280, 1290) for treating a target volume (908); a computer system (918) comprising a processor (922), wherein the computer system is adapted for controlling the medical imaging system; and a memory (928) containing machine readable instructions (954, 956, 958, 962, 964, 966, 968, 970, 972, 974). Execution of the instructions cause the processor to: acquire (100, 200, 308) medical image data; reconstruct (102, 202, 310) a medical image (932) using the medical image data; receive (104, 204, 312) an image segmentation seed (600, 934) derived from a treatment plan (936), and identify (106, 210, 314) a treated volume (400, 700, 800) in the medical image by segmenting the medical image in accordance with the image segmentation seed.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: May 10, 2016
    Assignee: Koninklijke Philips N.V.
    Inventors: Heikki Juhani Nieminen, Max Oskar Köhler, Marko Tapani Hakkinen
  • Patent number: 9259493
    Abstract: Disclosed is a liver tumor-targeting ultrasound contrast agent. The ultrasound contrast agent includes a gas-generating core and a hyaluronic acid shell. The ultrasound contrast agent can be specifically delivered to liver cells. This specific delivery enables easy differentiation between normal liver cells and liver tumor cells by ultrasound imaging. In addition, the ultrasound contrast agent is highly stable in aqueous condition and causes no cytotoxicity. Also disclosed is a method for preparing the ultrasound contrast agent.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: February 16, 2016
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Kwang Meyung Kim, Ick Chan Kwon, Inchan Youn, Hyun Su Min, Hong Yeol Yoon, Jae Hyung Park
  • Patent number: 9138491
    Abstract: The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (?-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a ?-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (?-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof. The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (?PGA) and cationic chitosan.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: September 22, 2015
    Assignees: BIOLEADERS CORPORATION, THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY, KOOKMIN UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Moon-Hee Sung, Yong Taik Lim, Young-Woock Noh, Il Han Lee, Hyun Min Kim
  • Publication number: 20150132231
    Abstract: Method and compositions are provided that relate to superparamagnetic nanoparticles, including IONP with small diameter and high transverse relaxivity, that are stable in an aqueous environment. The nanoparticle surface coating is functionalized, while minimizing its thickness, to facilitate packaging within biological constructs.
    Type: Application
    Filed: November 5, 2014
    Publication date: May 14, 2015
    Inventors: Benjamin Yen-Bin Ko, James Robert Swartz
  • Publication number: 20150125401
    Abstract: The present invention provides compositions and methods for the delivery of therapeutics to a cell or subject.
    Type: Application
    Filed: April 15, 2013
    Publication date: May 7, 2015
    Inventors: Howard E. Gendelman, Alexander V. Kabanov, Xin-Ming Liu, Richey M. Davis, Judy Riffle
  • Patent number: 9006384
    Abstract: Fasteners, such as bolts, nuts and screws, rivets, pins, and retaining rings, made of a highly kinked rigid-rod polyarylene exhibiting outstanding characteristics, notably a high torque and a high tensile elongation, a measure of practical toughness.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: April 14, 2015
    Assignee: Solvay Specialty Polymers USA, LLC
    Inventors: Gregory C. Plithides, Suresh Sriram
  • Publication number: 20150093335
    Abstract: Disclosed are a cell-targeted nano-material and biomedical uses thereof. The magnetic nano-material can bind with specificity to iron protein receptors having high expression on the surface of tissue cells, and can enter the cells. The present material can bind with specificity to a broad spectrum of tissue cells having a high expression of iron protein receptors, and can enable highly efficient cell targeting in animal models. The material can be used as a magnetic resonance imaging contrast and a fluorescent molecular probe for disease diagnosis, as well as a vector of medicine for disease treatment.
    Type: Application
    Filed: January 21, 2013
    Publication date: April 2, 2015
    Applicant: Institute of Geology and Geophysics, Chinese Academy of Sciences
    Inventors: Yongxin Pan, Changqian Cao, Lanxiang Tian, Yao Cai, Rixiang Zhu
  • Publication number: 20150079006
    Abstract: The present invention relates to iron oxide nanocomposite, magnetic resonance imaging T2 contrast medium comprising same, and method for manufacturing same. More particularly, the present invention is directed to An MRI (magnetic resonance imaging) T2 contrast agent, comprising an iron oxide nanocomposite which includes an iron oxide nanoparticle, wherein said iron oxide nanoparticle is encapsulated with a surfactant and said surfactant is encapsulated with polyethylene glycol-phospholipid and method for preparing the same.
    Type: Application
    Filed: April 1, 2013
    Publication date: March 19, 2015
    Inventors: Taeghwan Hyeon, Nohyun Lee, Seung H. Choi
  • Publication number: 20150079007
    Abstract: Tunable nanoparticles and methods of use thereof are provided. In accordance with the instant invention, tunable nanoparticles comprising a metal nanoparticle core (e.g., a paramagnetic particle (e.g., USPIO) or a quantum dot) and a polymer linked to a metal binding moiety are provided. The polymer of the nanoparticle is bound to the metal nanoparticle core by the metal binding moiety and coats the metal nanoparticle core. In a particular embodiment, the metal binding moiety comprises bisphosphonate, pyrophosphate, or a derivative thereof. In a particular embodiment, the polymer is a hydrophilic polymer, an amphiphilic block copolymer or an ionic block copolymer.
    Type: Application
    Filed: April 22, 2013
    Publication date: March 19, 2015
    Applicant: Board of Regents of the University of Nebraska
    Inventors: Xin-Ming Liu, Alexander V. Kabanov, Howard E. Gendelman
  • Publication number: 20150071863
    Abstract: The invention relates to compositions of DOTA derivative compounds, lanthanoid-DOTA derivative molecular complex, and lanthanoid-complex encapsulated solid lipid particles or capsules, and methods of making and using the compositions. The solid lipid particles or capsules contain micelle cores stabilized by a hyperbranched polymer shell based from a crosslinked DOTA derivative compound or crosslinked lanthanoid-DOTA derivative complex. These solid lipid particles or capsules can be used in various applications, such as contrast agents or drug delivery vehicles.
    Type: Application
    Filed: September 22, 2014
    Publication date: March 12, 2015
    Inventor: Marc Anton WALTERS
  • Publication number: 20150065858
    Abstract: The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and/or MRI applications (e.g., tumor treatment and/or imaging). In certain embodiments, the core-satellite nanocomposites comprise: i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, and ii) at least one satellite component attached to, or absorbed to, the biocompatible coating. In some embodiments, the nanoparticle core and satellite component are composed of near-infrared photothermal agent material and/or MRI contrast agent material. In further embodiments, the satellite component is additionally or alternatively composed of near-infrared optical dye material.
    Type: Application
    Filed: September 3, 2014
    Publication date: March 5, 2015
    Inventors: Hongwei Chen, Duxin Sun
  • Publication number: 20150050217
    Abstract: The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.
    Type: Application
    Filed: April 12, 2013
    Publication date: February 19, 2015
    Applicants: Universite Claude Bernard Lyon I, Nano-H, Centre National de la Recherche Scientifique-CNRS, Universite Joseph Fourier
    Inventors: Yannick Cremillieux, Andrea Bianchi, Sandrine Dufort, Jean-Luc Coll, Francois Lux, Olivier Tillement
  • Patent number: 8945513
    Abstract: A nanoshell is disclosed, comprising a star polymer occlusion complex comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent polymer arms, and ii) a cargo material occluded in the star polymer; and a shell comprising an inorganic material in contact with a peripheral surface of the star polymer occlusion complex.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: February 3, 2015
    Assignees: International Business Machines Corporation, San Jose State University Research Foundation
    Inventors: Victor Yee-Way Lee, Robert Dennis Miller, Joseph Sly, Melia Tjio
  • Patent number: 8940275
    Abstract: An agent for imaging of a biological system or delivering drugs to a biological system including one or more nanoparticles formed of at least one gadolinium coordination polymer.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: January 27, 2015
    Assignees: Kent State University, Case Western Reserve University
    Inventors: Songping D. Huang, Yongxiu Li, James P. Basilion, Jihua Hao, Christopher Flask
  • Patent number: 8932560
    Abstract: A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: January 13, 2015
    Assignees: University of Maryland, College Parke, University of Maryland, Baltimore
    Inventors: Matthew Dowling, John Hess, Grant Bochicchio, Srinivasa Raghavan
  • Publication number: 20150004103
    Abstract: New types of nanoparticle-based dual-modality positron emission tomography/magnetic resonance imaging (PET/MRI) and positron emission tomography/computed tomography (PET/CT) tumorspecific contrast agents have been developed. The base of the new type contrast agents is biopolymer-based nanoparticle with PET, MRI and CT active ligands. The nanoparticle contains at least one polyanion and polycation, which form nanoparticles via ion-ion interaction. The self-assembled polyelectrolytes can transport gold nanoparticles as CT contrast agents, or SPION or Gd(III) ions as MRI active ligands, and are labeled using a complexing agent with gallium as PET radiopharmacon. Furthermore, these dual modality PET/MRI and PET/CT contrast agents are labeled with targeting moieties to realize the tumorspecificity.
    Type: Application
    Filed: December 19, 2013
    Publication date: January 1, 2015
    Applicant: BBS NANOTECHNOLOGY LTD.
    Inventors: János BORBÉLY, István HAJDU, Magdolna BODNÁR, Zsuzsanna CSIKÕS
  • Patent number: 8916134
    Abstract: The disclosure provides metal nanocomposites including one or more metal nanoparticles having a hydrophobic surface and at least partially enclosed by cationic and hydrophilic polymers. The metal nanocomposites are useful as among others, a contrast agent, a diagnostic composition or a pharmaceutical composition.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: December 23, 2014
    Assignee: Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Seung Joo Haam, Sung Baek Seo, Jae Moon Yang
  • Patent number: 8916135
    Abstract: The present disclosure is directed generally to lanthanide nanoparticle conjugates, such as gadolinium nanoparticle conjugates, nanoparticle conjugates including polymers, conjugation to targeting agents and therapeutic agents, and their use in targeting, treating, and/or imaging disease states in a patient.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: December 23, 2014
    Assignees: Colorado School of Mines, Colorado State University Research Foundation
    Inventors: Stephen G. Boyes, Misty D. Rowe, Douglas H. Thamm, Susan L. Kraft
  • Publication number: 20140369939
    Abstract: Injectable compositions for the MRI detection of an analyte selected from the group consisting of reactive oxygen species, proteases and enzymes, comprising a) a matrix material based on a responsive hydrophobic polymer capable of undergoing a chemical reaction with the analyte to be detected, such reaction leading to a disruption of the polymer chain of the responsive polymer, b) a contrast agent suitable for use in magnetic resonance imaging, embedded in or encapsulated in the polymer a), c) optionally, a functionality capable of binding a marker or probe or a probe for creating a second detection signal, and d) optionally, a non-responsive polymer not undergoing a chemical reaction with the analyte under the conditions where polymer a) undergoes a reaction leading to chain breakage
    Type: Application
    Filed: June 10, 2014
    Publication date: December 18, 2014
    Inventors: V. PRASAD SHASTRI, Pradeep P. Wyss
  • Patent number: 8889103
    Abstract: A diagnostic agent composition is provided which comprises a nanoparticle composition and a pharmaceutically acceptable carrier or excipient. The nanoparticle composition comprises a nanoparticulate metal oxide and a phosphorylated polyol, wherein the phosphorylated polyol comprises at least two phosphate groups and one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. The disclosure provides detailed guidance on methods of making and using such diagnostic agent compositions. The diagnostic agent compositions provided by the present invention are useful as contrast agents for medical diagnostic imaging techniques such as magnetic resonance (MR) imaging and X-ray imaging. The diagnostic agent composition may be administered to a subject via a variety of techniques, among them injection, inhalation, and ingestion.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: November 18, 2014
    Assignee: General Electric Company
    Inventors: Bruce Allan Hay, Brian Christopher Bales, Michael Todd Luttrell, Binil Itty Ipe Kandapallil
  • Publication number: 20140314679
    Abstract: Provided are compositions for rapid detection of lymph nodes. The compositions include magnetic particles, such as iron oxide, and a solute present in an amount that results in a hypoosomotic solution. Methods for detecting lymph nodes also are provided.
    Type: Application
    Filed: March 10, 2014
    Publication date: October 23, 2014
    Applicant: ENDOMAGNETICS LTD.
    Inventors: Andrew P. Shawcross, John Gonzalez-Carvajal, Marc Brown, Rob Turner
  • Patent number: 8865129
    Abstract: The invention relates to compositions of DOTA derivative compounds, lanthanoid-DOTA derivative molecular complex, and lanthanoid-complex encapsulated solid lipid particles or capsules, and methods of making and using the compositions. The solid lipid particles or capsules contain micelle cores stabilized by a hyperbranched polymer shell based from a crosslinked DOTA derivative compound or crosslinked lanthanoid-DOTA derivative complex. These solid lipid particles or capsules can be used in various applications, such as contrast agents or drug delivery vehicles.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: October 21, 2014
    Assignee: New York University
    Inventor: Marc Anton Walters
  • Patent number: 8828357
    Abstract: Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T2 contrast effect, and also can be used as a storage or a carrier for drugs and so on, are disclosed. The iron oxide nano contrast agents can be prepared by the steps of: coating surfaces of hydrophobic FeO nanoparticles with a coating material selected from the group consisting of polyethylene glycol-phospholipid conjugate, dextran, chitosan, dimercaptosuccinic acid and mixtures thereof in an organic solvent to form hydrophilic FeO nanoparticles having hydrophilic surfaces and dispersibility in water; dispersing the hydrophilic FeO nanoparticles in water to oxidize FeO; and exposing the oxidized hydrophilic FeO nanoparticles to an acidic buffer to dissolve and remove interior unoxidized FeO portions, and thereby to form Fe3O4 nanoparticles having an interior space.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: September 9, 2014
    Assignee: Korea Basic Science Institute
    Inventors: Chulhyun Lee, Sung Lan Jeon, Min Kyung Chae, Jee-Hyun Cho, Eun Ju Jang
  • Patent number: 8821837
    Abstract: The invention discloses an aqueous method of making polymer coated superparamagnetic nanoparticles. Nanoparticles made by the method are included in the invention.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: September 2, 2014
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Jesus Manuel Perez, Sudip Nath
  • Publication number: 20140241996
    Abstract: Provided herein are therapeutic nanoparticles having a diameter of between 10 nm to 30 nm, and containing a polymer coating, and a nucleic acid containing a sequence complementary to a sequence within a micro-RNA identified as having a role in cancer cell metastasis or anti-apoptotic activity in a cancer cell (e.g., miR-10b) or a sequence within an mRNA encoding a pro-apoptotic protein that is covalently linked to the nanoparticle. Also provided are pharmaceutical compositions containing these therapeutic nanoparticles. Also provided herein are methods of decreasing cancer cell invasion or metastasis in a subject having a cancer and methods of treating a metastatic cancer in a lymph node in a subject that require the administration of these therapeutic nanoparticles to a subject.
    Type: Application
    Filed: July 19, 2012
    Publication date: August 28, 2014
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Zdravka Medarova, Mehmet V. Yigit, Anna Moore
  • Publication number: 20140219926
    Abstract: A biodegradable iron oxide nanoparticle gel for hyperthermia treatment of cancer includes a polysaccharide-based carrier matrix and starch-coated iron oxide nanoparticles. The gel has sufficient deformability to integrate into a diffuse tumor site, adheres to tissue and has sufficient mechanical properties to remain in place during hyperthermia treatment. The gel releases iron oxide nanoparticles for uptake by cancerous cells at the tumor margin.
    Type: Application
    Filed: February 3, 2014
    Publication date: August 7, 2014
    Applicant: The Trustees Of Dartmouth College
    Inventors: Benjamin P. Cunkelman, Jennifer A. Tate, Alicia A. Petryk, P. Jack Hoopes, Robert J. Collier, Sara G. Thappa
  • Publication number: 20140170077
    Abstract: The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (?-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a ?-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (?-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof. The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (?PGA) and cationic chitosan.
    Type: Application
    Filed: April 7, 2011
    Publication date: June 19, 2014
    Applicants: THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM, BIOLEADERS CORPORATION
    Inventors: Moon-Hee Sung, Yong Taik Lim, Young-Woock Noh, Il Han Lee, Hyun Min Kim
  • Publication number: 20140170078
    Abstract: The invention relates to a magnetic resonance imaging T2 contrast medium (agent) for cell contrasting, and to a method for manufacturing the same. The magnetic resonance imaging T2 contrast agent for imaging at cellular level comprises magnetic nanoparticles exhibiting ferrimagnetism at room temperature, has a very high relaxivity, and has an effective uptake into cells. Thus, the T2 contrast agent may effectively mark various types of cells, and in vitro and in vivo magnetic resonance imaging at the single cell level may he realized.
    Type: Application
    Filed: June 14, 2011
    Publication date: June 19, 2014
    Applicant: SNU R&DB FOUNDATION
    Inventors: Taeghwan Hyeon, Nohyun Lee, Woo Kyung Moon, Seung Hong Choi, Hyoungsu Kim
  • Publication number: 20140161734
    Abstract: Disclosed are a composition including hydrophilic nanoparticles that have a monosaccharide-phosphate or a derivative thereof adhered to the surface thereof, a colloidal solution of the composition dispersed in water, and a magnetic resonance imaging contrast agent including the colloidal solution. According to the present invention, nanoparticles having biocompatibility and excellent water-dispersibility can be prepared by modifying the surface of inorganic nanoparticles. The prepared nanoparticles may be effectively used in a variety of applications including, for example, in vivo imaging applications such as an MRI contrast agent, nano-electronic convergence technologies such as a quantum dot light emitting device, biomedical applications such as hyperthermia, or the like. Moreover, compared to existing nanoparticles dispersed by a dispersion stabilizer known in the art, excellent dispersion stability and a relatively small hydrodynamic diameter may be attained.
    Type: Application
    Filed: August 3, 2012
    Publication date: June 12, 2014
    Applicant: HANWHA CHEMICAL CORPORATION
    Inventors: Eung Gyu Kim, Bong-Sik Jeon, Eun Byul Kwon, Ju Young Park, Wan Jae Myeong
  • Patent number: 8742064
    Abstract: Medical tubing (T), such as a guidewire, a stent, a catheter or a hollow needle, made of a kinked rigid-rod polyarylene exhibiting a outstanding characteristics including high torqueability, high pushability and high flexibility and which can be easily thin-wall extruded under especially harsh conditions.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: June 3, 2014
    Assignee: Solvay Advanced Polymers, L.L.C.
    Inventors: Mohammad Jamal El-Hibri, Brian Baleno, Nikica Maljkovic, Bianca Sadicoff Shemper, Jean-Baptiste Bonnadier, Daniel J. Ireland, Henri N. J. Massillon
  • Patent number: 8729030
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: May 20, 2014
    Assignee: Affymax, Inc.
    Inventors: Christopher P. Holmes, Qun Yin, Guy Lalonde, Peter J. Schatz, David Tumelty, Palani Balu, Genet Zemede
  • Publication number: 20140086846
    Abstract: A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX): wherein R1, R2, R3, R7, R8, R?1, R?2, R?3, R7? and R8? are selected form hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group; R4, R?4 are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5, R?5 are selected from a hydrogen, a protecting group comprising C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 1 and 10; at least one of R7 and R?7 is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.
    Type: Application
    Filed: September 26, 2012
    Publication date: March 27, 2014
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Brian James Grimmond, Michael James Rishel, Jeannette Christine Roberts
  • Publication number: 20140050670
    Abstract: The invention provides a nanoparticle for delivery of therapeutic agents, comprising a polymeric nanosphere and one or more detection agents, said detection agents for use in detecting the location of the nanoparticle. The invention further provides a transfection agent comprising an aforementioned nanoparticle.
    Type: Application
    Filed: December 7, 2011
    Publication date: February 20, 2014
    Applicant: THE UNIVERSITY OF WESTERN AUSTRALIA
    Inventors: Killugudi L. Iyer, Cameron William Evans, Tristan Devere Clemons, Melinda Fitzgerald, Sarah Alison Dunlop, Igor Luzinov, Bogdan Zdyrko
  • Patent number: 8637028
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: January 28, 2014
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, The Brigham and Women's Hospital
    Inventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti