Metal Is Paramagnetic Patents (Class 424/9.323)
  • Patent number: 11219698
    Abstract: The present invention relates to a magnetic resonance imaging (MRI) contrast agent, particularly a metal oxide nanoparticle-based T1-T2 dual-mode MRI contrast agent that can be used not only as a T1 MRI contrast agent but also as a T2 MRI contrast agent, and a method for producing the same. The metal oxide nanoparticle-based T1-T2 dual-mode MRI contrast agent can provide more accurate and detailed information associated with disease than single MRI contrast agent by the beneficial contrast effects in both T1 imaging with high tissue resolution and T2 imaging with high feasibility on detection of a lesion.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: January 11, 2022
    Assignee: INTRON BIOTECHNOLOGY, INC.
    Inventors: Kwang Yeol Lee, Min Sik Kim, Taek Hoon Kim, Ngoc Phan Vu
  • Patent number: 10413614
    Abstract: The present invention relates to a conjugate containing at least one kidney-selective carrier molecule and at least one active compound which has a protective action for the kidney against nephrotoxic active compounds, to a process for the preparation of the conjugate, to the use thereof for the protection of the kidney against nephrotoxic active compounds, and to a medicament comprising the conjugate.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: September 17, 2019
    Assignee: Merck Patent GmbH
    Inventors: Armin Kuebelbeck, Gregor Larbig, Stefan Arnold, Walter Mier, Uwe Haberkorn
  • Patent number: 10227376
    Abstract: The disclosure provides compounds, methods, and kits for diagnosis, detection, screening, and imaging of a disease condition (e.g., infection, cancer, tumor, neoplasia), in vitro, ex vivo, and/or in vivo. Certain embodiments include administering a cationic steroid antimicrobial (a “CSA” or “ceragenin”), the CSA including a steroidal backbone and a heterocyclic ring separated from the steroidal backbone by at least 4 atoms (and up to 24 atoms or more), to a subject having or at risk of having a disease condition in an amount effective to diagnose, detect, screen for or image the disease condition in the subject.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: March 12, 2019
    Assignee: BRIGHAM YOUNG UNIVERSITY
    Inventor: Paul B. Savage
  • Patent number: 10117937
    Abstract: Compositions including a highly branched alpha-D-glucan or modified forms thereof and a solute compound are described herein. The compositions can provide increased water solubility and/or increased rate of dissolution for the solute compound. The compositions can also provide increased stability for the solute compound. Methods for preparing and using compositions including a solute compound and a highly branched alpha-D-glucan are also described.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: November 6, 2018
    Assignees: PURDUE RESEARCH FOUNDATION, PHYTOPTION, LLC.
    Inventors: Yuan Yao, Jingmin Zhang
  • Patent number: 9512150
    Abstract: Thermal conductive compositions, methods for their preparation, and use are provided, which include, for example, as thermal sinks and other uses.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: December 6, 2016
    Assignee: Empire Technology Development LLC
    Inventors: Georgius Abidal Adam, Mordehai Margalit, Bradley Kirk Roberts, Feng Wan
  • Patent number: 9186433
    Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: November 17, 2015
    Assignees: National University Corporation Okayama University, Junsei Educational Institution
    Inventors: Yasuhiro Yoshida, Masato Tanaka, Kazuomi Suzuki, Toshifumi Ozaki, Tomohiro Takahata, Masao Irie, Mariko Nakamura, Mitsunobu Kawashima, Yamato Nojiri, Koichi Okada, Masahiro Nagao
  • Patent number: 9080933
    Abstract: The present disclosure utilizes the aggregation of stimuli-responsive polymers to isolate a diagnostic target (e.g., an antigen) from a solution using magnetophoresis. Isolating the diagnostic target provides a route to identify the presence of the diagnostic target in the solution.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: July 14, 2015
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Patrick S. Stayton, Jriuan Lai, Barrett J. Nehilla, Selvi Srinivasan
  • Publication number: 20150139914
    Abstract: The present invention relates to a contrast agent for nuclear magnetic resonance imaging, and more particularly, to a contrast agent for nuclear magnetic resonance imaging containing melanin nanoparticles having a uniform shape and size, thereby providing good dispersibility in water, no cell toxicity, and a long retention time in vivo.
    Type: Application
    Filed: April 9, 2013
    Publication date: May 21, 2015
    Inventors: Jin Kyu Lee, Kuk Youn Ju, Jung Hee Lee
  • Patent number: 9005582
    Abstract: A medical delivery system that enables the delivery of therapeutic agents to malignant tissue utilizing delivery agents and heating of the delivery agents thereby causing the release of the therapeutic agents within the tumor is disclosed. The therapeutic agents may be chemotherapy agents, radiation therapy agents, and other appropriate materials. The magnetic nanoparticles encapsulated by the therapeutic agents in a biocompatible coating may be delivered to tumor sites utilizing attenuated strains of bacteria that seek and reside at tumor sites. An alternating magnetic field device with a prescribed frequency range may be used to induce heating of the magnetic nanoparticles in the patient thereby melting the coating and releasing the therapeutic agents within the tumor.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: April 14, 2015
    Assignees: University of North Carolina at Greensboro, United Arab Emirates University
    Inventor: Yousef Haik
  • Patent number: 8974769
    Abstract: The present invention proposes a magnetic nanocomposite with multi-biofunctional groups, which comprises a core and a shell wrapping the core, wherein the core contains magnetic nanoparticles, and wherein the shell is made of a conductive polymer with multi-biofunctional groups where a medicine, an antibody or a fluorescent label can be attached.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: March 10, 2015
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hung-Wei Yang, Rung-Ywan Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Hao-Li Liu
  • Publication number: 20150064107
    Abstract: The invention relates to imaging agents, and in particular to multi-modal nanoparticle (NPIA) imaging agents offering magnetic, radionuclide and fluorescent imaging capabilities to exploit the complementary advantages of magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT) and optical imaging (OI). The invention extends to these new types of agents per se, and to uses of such agents in various biomedical applications, such as in therapy and in diagnosis.
    Type: Application
    Filed: August 28, 2014
    Publication date: March 5, 2015
    Applicant: King's College London
    Inventors: Xianjin Cui, Philip Blower, Mark A. Green
  • Publication number: 20150064116
    Abstract: Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising a polynucleotide. Also provided are methods of using the compositions for transfection and/or transformation of a cell with the polynucleotide. Further provided are methods of detecting transfection of a cell with the polynucleotide.
    Type: Application
    Filed: September 28, 2012
    Publication date: March 5, 2015
    Applicant: University of South Florida (A Florida Non-Profit Corporation)
    Inventors: Subhra Mohapatra, Chunyan Wang
  • Patent number: 8961935
    Abstract: The present invention relates to a magnetic resonance imaging (MRI) contrast agent coated with carboxylated mannan, particularly a carboxylated mannan coated superparamagnetic MRI contrast agent specifically targeting antigen presenting cells and having excellent in vivo stability, and a method for producing the same. The MRI contrast agent coated with carboxylated mannan of the present invention can provide excellent in vivo stability and biocompatibility owing to its high surface negative charge, and can be introduced specifically into antigen presenting cells owing to mannose of mannan, so as to visualize the antigen presenting cells and the tissue containing the antigen presenting cells in MRI.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: February 24, 2015
    Assignee: Intron Biotechnology, Inc.
    Inventors: Seong Jun Yoon, Soo Youn Jun, An Sung Kwon, Sang Hyeon Kang, Yong Yeon Jeong, In Kyu Park, Chong Su Cho, You Kyoung Kim, Won Jong Kim, Ran Namgung
  • Patent number: 8951501
    Abstract: A noninvasive thermometry monitoring system for determining a temperature of tissue to which hyperthermia treatment is administered is disclosed. The monitoring system may incorporate magnetic nanoparticles having known moments such that once exposed to an alternating magnetic field, the magnetic nanoparticles increase in temperature. Imaging systems can disclose the magnetic nanoparticles within a patient. The temperature of the magnetic nanoparticles can be determined by comparing the magnetic nanoparticle with known temperatures for that type of magnetic nanoparticle. The image of the magnetic nanoparticles may be compared with surrounding tissue to determine the temperature of the surrounding tissue that is exposed to hyperthermia treatment.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: February 10, 2015
    Assignees: University of North Carolina at Greensboro, United Arab Emirates University
    Inventor: Yousef Haik
  • Patent number: 8945509
    Abstract: Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: February 3, 2015
    Assignee: Life Technologies Corporation
    Inventors: Aldrich Lau, Robert Eason, Maxim Brevnov, Handong Li, Kevin Hacker
  • Publication number: 20150023882
    Abstract: The invention discloses an aqueous method of making polymer coated superparamagnetic nanoparticles. Nanoparticles made by the method are included in the invention.
    Type: Application
    Filed: June 25, 2014
    Publication date: January 22, 2015
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Jesus Manuel Perez, Sudip Nath
  • Patent number: 8906345
    Abstract: The invention provides multimeric particle comprising metal-containing particles covalently bonded to one another by linker groups wherein at least some of said linker groups are cleavable. The invention further provides a contrast agent comprising said multimeric particles, along with a method of improving contrast of an image using said contrast agent.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: December 9, 2014
    Assignee: Isis Innovation Limited
    Inventors: Daniel Anthony, Benjamin Guy Davis, Nicola Sibson
  • Patent number: 8889103
    Abstract: A diagnostic agent composition is provided which comprises a nanoparticle composition and a pharmaceutically acceptable carrier or excipient. The nanoparticle composition comprises a nanoparticulate metal oxide and a phosphorylated polyol, wherein the phosphorylated polyol comprises at least two phosphate groups and one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. The disclosure provides detailed guidance on methods of making and using such diagnostic agent compositions. The diagnostic agent compositions provided by the present invention are useful as contrast agents for medical diagnostic imaging techniques such as magnetic resonance (MR) imaging and X-ray imaging. The diagnostic agent composition may be administered to a subject via a variety of techniques, among them injection, inhalation, and ingestion.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: November 18, 2014
    Assignee: General Electric Company
    Inventors: Bruce Allan Hay, Brian Christopher Bales, Michael Todd Luttrell, Binil Itty Ipe Kandapallil
  • Publication number: 20140328768
    Abstract: Provided is an iron oxide nanocapsule which has extremely excellent water dispersibility, which is very stable in the body and which has very excellent MRI contrast ability, a method of manufacturing the same, and an MRI contrast agent using the same. The method of manufacturing the iron oxide nanocapsule includes the steps of: thermally decomposing an iron complex to prepare hydrophobic ligand-bonded iron oxide nanoparticles; and encapsulating the hydrophobic ligand-bonded iron oxide nanoparticles by a carboxymethyldextrandodecylamine conjugate encapsulation material or a dextran-linoleic acid conjugate encapsulation material to form an iron oxide nanocapsule.
    Type: Application
    Filed: August 31, 2011
    Publication date: November 6, 2014
    Applicant: HANWHA CHEMICAL CORPORATION
    Inventors: Eun Byul Kwon, Bong Sik Jeon, Eung Gyu Kim, Ju Young Park, Wan Jae Myeong
  • Patent number: 8840868
    Abstract: Methods of non-invasive imaging of complement-mediated inflammation are provided. Compositions including CR-targeted ultrasmall superparamagnetic nanoparticles or aggregates thereof for use with those methods are also provided.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: September 23, 2014
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Joshua M. Thurman, Natalie Serkova, Conrad Stoldt, Brian Larsen, V. Michael Holers
  • Publication number: 20140234226
    Abstract: The various embodiments herein provide for the engineered multimodal super paramagnetic iron oxide nanoparticles (SPIONs) with a fluorescent dye. The SPIONs comprise fluorescent polymer dye arranged in a gap between a SPION core and a gold shell. The SPIONS are provided with a gold coating. The gap is made up of a polymeric molecule such as 6-arm anthracene terminated. The core of the nanoparticle is made up of a magnetic metal oxide. The method for synthesizing SPIONs involves preparing carboxyl-dextran complex and the SPIONS. The SPIONs are coated with carboxyl-dextran complex. The coated SPIONs coated are subjected to fluorescent polymer and gold nano shell coating. The prepared SPIONs are characterized by light scattering measurement and magnetization measurements.
    Type: Application
    Filed: May 6, 2014
    Publication date: August 21, 2014
    Inventors: Morteza Mahmoudi, Mohammad Ali Shokrgozar
  • Publication number: 20140178310
    Abstract: Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods.
    Type: Application
    Filed: July 9, 2013
    Publication date: June 26, 2014
    Inventors: Ernest V. Groman, Kenneth G. Paul, Timothy B. Frigo, Howard Bengele, Jerome M. Lewis
  • Publication number: 20140161733
    Abstract: A composition comprising: a liposome having a bilayer structure, a gadofullerene having a high relaxivity, and an amphiphilic receptor ligand. In the composition, the gadofullerene is embedded in the bilayer structure of the liposome. In addition, a method for detecting atherosclerotic plaque in an animal using the composition is described.
    Type: Application
    Filed: March 29, 2012
    Publication date: June 12, 2014
    Applicant: LUNA INNOVATIONS INCORPORATED
    Inventors: Zhiguo Zhou, Robert P. Lenk, Christopher L. Kepley
  • Publication number: 20140147391
    Abstract: A bioprobe based on surface-modified single-phase BaGdF5:Yb/Er upconversion nanoparticles (UCNPs) for multi-modal bioimaging of fluorescent, magnetic resonance imaging (MRI) and computed X-ray tomography (CT) is disclosed herein. The modified UCNPs of the present invention are synthesized by a facile one-pot hydrothermal method with simultaneous surface modification of the nanoparticles. The surface-modified UCNPs of the present invention are useful in a variety of biomedical application fields due to their advantages in in vitro and in vivo multi-modal bioimaging such as small particle size up to 15 nm, substantially free of autofluorescence, low cytotoxicity, capable of being excited at near-infrared (NIR) wavelength, ability to deep cell penetration, long-lasting signal and long circulation time in vivo, different X-ray absorption coefficients at different photon energy levels between Ba and Gd, large magnetic moment, etc.
    Type: Application
    Filed: November 28, 2012
    Publication date: May 29, 2014
    Applicant: THE HONG KONG POLYTECHNIC UNIVERSITY
    Inventors: Jianhua HAO, Songjun ZENG
  • Publication number: 20140127138
    Abstract: Composition and method for surface-functionalized SPION-based agents. Such agents can provide highly pH-sensitive MRI contrast in tissue.
    Type: Application
    Filed: November 5, 2013
    Publication date: May 8, 2014
    Applicant: Board of Trustees of Southern Illinois University
    Inventors: Yong Gao, Boyd Goodson
  • Publication number: 20140112873
    Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
    Type: Application
    Filed: May 17, 2012
    Publication date: April 24, 2014
    Applicants: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM, ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, INTEZYNE TECHNOLOGIES INC.
    Inventors: Robert J. Gillies, David L. Morse, Natalie M. Barkey, Kevin N. Sill, Josef Vagner, Narges K. Tafreshi, Jonathan L. Sessler, Christian Preihs, Victor J. Hruby
  • Publication number: 20140105828
    Abstract: This disclosure relates to nanoparticles carrying nucleic acid cassettes for expressing RNA. In certain embodiments, the disclosure relates to improved methods for targeted delivery and expression of siRNAs in vivo using DNA-based siRNA-expressing nanocassettes and receptor-targeted nanoparticles. In certain embodiments, the disclosure relates to methods of targeted delivery of survivin siRNA expressing nanocassettes which enhance sensitivity of human cancer cells to anticancer agents.
    Type: Application
    Filed: October 14, 2013
    Publication date: April 17, 2014
    Applicant: Emory University
    Inventor: Lily Yang
  • Publication number: 20140099266
    Abstract: Targeting contrast agent for magnetic resonance imaging (MRI). In preferred embodiments, self-assembled polyelectrolytes coated superparamagnetic iron oxide contrast agent particles are provided, which are labeled with targeting moieties, afforded enhanced relaxivity, improved signal-to-noise and targeting ability. Accordingly, the invention relates to a stable targeting contrast nanosystem applicable for magnetic resonance imaging (MRI) having at least one nanoparticle polyelectrolyte polyanion; a targeting agent conjugated to the biopolymer; and a superparamagnetic ligand. In another embodiment the nanosystem according to the invention has at least two biocompatible and biodegradable nanoparticle polyelectrolyte biopolymer. Particularly, the superparamagnetic iron oxide particles are coated by a polyelectrolyte biopolymer and this system self-assembles with the other biopolymer to produce stable nanosystem for magnetic resonance imaging.
    Type: Application
    Filed: July 17, 2013
    Publication date: April 10, 2014
    Applicant: BBS NANOTECHNOLOGY LTD.
    Inventors: Janos BORBELY, Istvan HAJDU, Jozsef KOLLAR, Magdolna BODNAR, Zsuzsanna CSIKOS
  • Patent number: 8679458
    Abstract: A method and system for simply and efficiently determining quantities of a preselected material in a particular solution by the placement of at least one superparamagnetic nanoparticle having a specified functionalized organic material connected thereto into a particular sample solution, wherein preselected analytes attach to the functionalized organic groups, these superparamagnetic nanoparticles are then collected at a collection site and analyzed for the presence of a particular analyte.
    Type: Grant
    Filed: November 7, 2007
    Date of Patent: March 25, 2014
    Assignee: Battelle Memorial Institute
    Inventors: Wassana Yantasee, Maryin G. Warner, Cynthia L. Warner, Raymond S. Addleman, Glen E. Fryxell, Charles Timchalk, Mychailo B. Toloczko
  • Publication number: 20140079644
    Abstract: In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC-Ac) covalently linked to: at least one poly(ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is provided.
    Type: Application
    Filed: November 19, 2013
    Publication date: March 20, 2014
    Applicant: ONTARIO INSTITUTE FOR CANCER RESEARCH
    Inventors: Shyh-Dar Li, Mark John Ernsting, Wei-Lun Tang
  • Publication number: 20140050671
    Abstract: Nanoparticle having a poly(beta-amino ester) coating. The poly(beta-amino ester) coating includes one or more therapeutic agents that can be delivered by the particle and one or more anchoring groups that couple the polymer to the nanoparticle's core surface. In certain embodiments, the poly(beta-amino ester) includes one or more polyalkylene oxide groups. The poly(beta-amino ester) can further include a targeting agent to target the nanoparticle to a site of interest and a diagnostic agent that allows for imaging of the particle. Methods for making and using the nanoparticles are also provided.
    Type: Application
    Filed: August 16, 2013
    Publication date: February 20, 2014
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Chen Fang
  • Publication number: 20140044648
    Abstract: An activatable probe and methods of using the same are provided. The activatable probe includes a superparamagnetic core and a polymeric matrix coating the metal oxide core. A paramagnetic agent encapsulated within the polymeric matrix. The polymeric matrix is configured to release the paramagnetic agent when subjected to a medium having a pH less than a normal physiological pH.
    Type: Application
    Filed: July 8, 2013
    Publication date: February 13, 2014
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: J. Manuel Perez, Santimukul Santra
  • Publication number: 20130302255
    Abstract: Disclosed are novel, targeting, paramagnetic nanoparticles as contrast agent for magnetic resonance imaging. The compositions of the nanoparticles are composed of self-assembled polyelectrolyte biopolymers having targeting moieties, which can suitable for targeted delivery of paramagnetic ions complexed to the nanoparticles. The nanoparticulate contrast agent can internalize into the targeted tumor cells to realize the receptor mediated uptake, and therefore afford enhanced relaxivity and improved signal-to-noise effect on the examined tissue areas. Methods for making these targeting MRI contrast agents are also provided.
    Type: Application
    Filed: May 7, 2013
    Publication date: November 14, 2013
    Inventors: János BORBÉLY, István HAJDÚ, Magdolna BODNÁR, Ildikó SCRIFFERTNÉ DENYICSKA
  • Publication number: 20130302256
    Abstract: This invention discloses a synthetic procedure for preparing nanoparticulate materials of various metal cyanide compounds containing manganese(II) ions in the crystal lattice with the surfaces coated by a hydrophilic compound, and their use as MRI contrast agents with high sensitivity, long blood circulation half lives and low toxicity at low-field and high field MR scanners.
    Type: Application
    Filed: August 29, 2011
    Publication date: November 14, 2013
    Applicant: KENT STATE UNIVERSITY
    Inventors: Songping D. Huang, Anatoly K. Khitrin, Vindya S. Perera, Murthi S. Kandanapitiye
  • Patent number: 8563298
    Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: October 22, 2013
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., Mark John Audeh, James Franklin Chepin, Rahul Dhanda, Lori Anne Neely, Charles William Rittershaus
  • Patent number: 8557290
    Abstract: The present invention relates to nanoconjugates. In particular, the present invention provides nanoconjugates for diagnostic (e.g., imaging), research, and clinical (e.g., targeted treatment) applications.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: October 15, 2013
    Assignee: Northwestern University
    Inventors: Ai-Guo Wu, Tatjana Paunesku, Gayle E. Woloschak
  • Publication number: 20130209369
    Abstract: An agent for imaging of a biological system or delivering drugs to a biological system including one or more nanoparticles formed of at least one gadolinium coordination polymer.
    Type: Application
    Filed: September 8, 2011
    Publication date: August 15, 2013
    Applicant: Case Western Reserved University
    Inventors: Songping D. Huang, Yongxiu Li, James P. Basilion, Jihua Hao, Christopher Flask
  • Publication number: 20130195767
    Abstract: A magnetic nanoparticle includes a magnetic core and a superparamagnetic outer shell, in which the outer shell enhances magnetic properties of the nanoparticle. The enhanced magnetic properties of the magnetic nanoparticle allow for highly sensitive detection as well as diminished non-specific aggregation of nanoparticles.
    Type: Application
    Filed: May 26, 2011
    Publication date: August 1, 2013
    Inventors: Ralph Weissleder, Hakho Lee, Tae-Jong Yoon
  • Publication number: 20130121929
    Abstract: Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods.
    Type: Application
    Filed: January 4, 2013
    Publication date: May 16, 2013
    Applicant: AMAG Pharmaceuticals, Inc.
    Inventor: AMAG Pharmaceuticals, Inc.
  • Publication number: 20130121928
    Abstract: An improved method for diagnosing and characterizing peripheral nerve lesions to permit early identification and characterization of peripheral nerve injuries that will require surgical intervention.
    Type: Application
    Filed: November 13, 2012
    Publication date: May 16, 2013
    Inventor: Sam Popinchalk
  • Publication number: 20130108554
    Abstract: The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
    Type: Application
    Filed: December 19, 2012
    Publication date: May 2, 2013
    Applicant: Northwestern University
    Inventors: Elise A. Schultz Sikma, Mohammed Aslam, Vinayak P. Dravid, Thomas J. Meade, Bradley D. Ulrich
  • Publication number: 20130095043
    Abstract: The present invention relates to a method of forming iron oxide nanoparticles comprising the steps of (a) suspending iron oxide/hydroxide and oleic acid or a derivative thereof in a primary organic solvent; (b) increasing the temperature of the suspension by a defined rate up to a maximum of 340° C. to 500° C.; (c) aging the suspension at the maximum temperature of step (b) for about 0.5 to 6 h; (d) cooling the suspension; (e) adding a secondary organic solvent; (f) precipitating nanoparticles by adding a non-solvent and removing excess solvent; (g) dispersing said nanoparticles in said secondary organic solvent; (h) mixing the dispersion of step (g) with a solution of a polymer; and (i) optionally removing said secondary organic solvent.
    Type: Application
    Filed: June 21, 2011
    Publication date: April 18, 2013
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Dirk Burdinski, Carmen Bohlender, Nicole P.M. Haex
  • Patent number: 8414866
    Abstract: The present invention relates to a magnetic resonance imaging (MRI) method, in particular to a MRI method enabling early detection of myocardial ischemia.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: April 9, 2013
    Assignee: GE Healthcare AS
    Inventors: Morten Eriksen, Geir Torheim
  • Patent number: 8367040
    Abstract: Contrast agents comprising a scaffold protein having at least one operative integrated metal ion binding site.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: February 5, 2013
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Jenny Jie Yang, Zhi-Ren Liu
  • Patent number: 8323618
    Abstract: The present invention provides biomimetic contrast agents, dual functional contrast agents effective for therapeutic gene delivery and magnetic nanoparticles which comprise functionalized iron oxide nanoparticle cores, one of an inert gold layer, a layer of inert metal seeds or a silica layer and, optionally, one or both of an outer gold-silver nanoshell or a targeting ligand attached to the inert gold layer or the gold-silver nanoshell. Also provided are methods of in vivo magnetic resonance imaging, of treating primary or metastatic cancers or of ablating atherosclerotic plaque using the contrast agents and magnetic particles. In addition, kits comprising the biomimetic contrast agents, dual contrast agents and magnetic nanoparticles.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: December 4, 2012
    Assignee: University of Houston System
    Inventor: Malavosklish Bikram
  • Publication number: 20120230919
    Abstract: The present invention relates to a magnetic resonance imaging (MRI) contrast agent coated with carboxylated mannan, particularly a carboxylated mannan coated superparamagnetic MRI contrast agent specifically targeting antigen presenting cells and having excellent in vivo stability, and a method for producing the same. The MRI contrast agent coated with carboxylated mannan of the present invention can provide excellent in vivo stability and biocompatibility owing to its high surface negative charge, and can be introduced specifically into antigen presenting cells owing to mannose of mannan, so as to visualize the antigen presenting cells and the tissue containing the antigen presenting cells in MRI.
    Type: Application
    Filed: April 15, 2011
    Publication date: September 13, 2012
    Applicant: INTRON BIOTECHNOLOGY, INC.
    Inventors: Seong Jun YOON, Soo Youn JUN, An Sung KWON, Sang Hyeon KANG, Yong Yeon JEONG, In Kyu PARK, Chong Su CHO, You Kyoung KIM, Won Jong KIM, Ran NAMGUNG
  • Publication number: 20120219496
    Abstract: The invention relates to nanocluster compositions and uses thereof. Specifically, the invention relates to gadolinium-linked nanocluster compositions and their use in diagnosis and prognosis of diseases. The nanocluster compositions of the invention are effective in enhancing the payload of a gadolinium and thereby increasing the longitudinal relaxivity of each particle in the cluster.
    Type: Application
    Filed: August 30, 2010
    Publication date: August 30, 2012
    Inventors: Andrew Tsourkas, Zhiliang Cheng
  • Patent number: 8236284
    Abstract: Disclosed are nanoparticles having a metallic core consisting essentially of superparamagnetic iron oxide; a polymeric coat surrounding said core, the coat having a matrix of polyacrylic acid and forming an outer periphery of said nanoparticle; a plurality of hydrophobic pockets formed by the polymeric coat; a plurality of carboxylic groups along an outer periphery of the polymeric coat and effective to conjugate with a predetermined targeting ligand which functionalizes the nanoparticle; a lipophylic fluorescent dye encapsulated in the plurality of hydrophobic pockets; and a drug encapsulated in the plurality of hydrophobic pockets. Associated methods of making the nanoparticles and of treatments using the nanoparticles are also disclosed.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: August 7, 2012
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: J. Manuel Perez, Santimukul Santra
  • Publication number: 20120164079
    Abstract: Methods for NMR microimaging of biological tissue are provided. Polymeric nanoparticles are provided as a contrast agent to subject tissue to be imaged. Each polymeric nanoparticle may include an iron oxide core that exhibits superparamagnetic properties that enhance tissue imaging when placed within a magnetic field, an anionic surfacant applied to the core, a polymeric layer that encapsulates the core and the anionic surfacant, and an antibody attached to the polymeric layer to facilitate attachment to the subject tissue. Following the provision of the polymeric nanoparticles as a contrast agent to the subject tissue, the subject tissue may be images utilizing a twenty-one Tesla microimaging technique.
    Type: Application
    Filed: March 2, 2012
    Publication date: June 28, 2012
    Applicant: Florida State University Research Foundation
    Inventor: Rakesh Sharma
  • Publication number: 20120141382
    Abstract: This invention relates to nucleic acid aptamers that recognize and bind the complement protein C3 or its biologically active proteolytic products and methods of their use. Particularly preferred are bi-functional aptamer construct that binding specifically with C3b or iC3b, and another target protein. Use of these molecular constructs for commandeering the opsonization process is also described herein.
    Type: Application
    Filed: May 20, 2009
    Publication date: June 7, 2012
    Applicant: Research Foundation of State University of New York at Albany
    Inventors: Hua Shi, Albert J.T. Millis, Kimi Nishikawa, Prabhat Kumar Mallik