Liquid Conveying (e.g., Vascular, Arterial, Bile Duct, Urethra) Patents (Class 427/2.25)
  • Patent number: 10424465
    Abstract: Introduced here is a plasma polymerization apparatus. Example embodiments include a reaction chamber in a shape substantially symmetrical to a central axis. Some examples further include a rotation rack in the reaction chamber. The rotation rack may be operable to rotate relative to the reaction chamber about the central axis of the reaction chamber. Examples may further include two reactive species discharge mechanisms positioned around a perimeter of the reaction chamber and configured to disperse reactive species into the reaction chamber in a substantially symmetrical manner from the outer perimeter of the reaction chamber toward the central axis of the reaction chamber, such that the reactive species form a polymeric coating on surfaces of the one or more substrates during said dispersion of the reactive species, and a collecting tube positioned along the central axis of the reaction chamber and having an air pressure lower than the reaction chamber.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: September 24, 2019
    Assignee: Jiangsu Favored Nanotechnology Co., LTD
    Inventor: Jian Zong
  • Patent number: 10232082
    Abstract: This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis. More specifically, a drug-eluting scaffold is implanted in the middle meatus to treat chronic sinusitis for weeks to months.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: March 19, 2019
    Assignee: 480 Biomedical, Inc.
    Inventors: Changcheng You, Quynh Pham, Danny Concagh
  • Patent number: 10219921
    Abstract: A tubular prosthesis that includes a scaffolding formed by at least one scaffolding filament; a cover; and at least one controlled ingrowth feature constructed and arranged to abut an inner surface of a lumen wall when the prosthesis is implanted in the body lumen. The controlled ingrowth feature may extend inwards or outwards from the prosthesis outer surface. The controlled ingrowth feature may be formed by a scaffolding filament; by a separate filament; by the cover; and combinations thereof.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: March 5, 2019
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Colby Harris, Stan R. Gilbert, John A. Hingston, William Bertolino, Claude O. Clerc, Petru Andrei
  • Patent number: 10207087
    Abstract: The present invention is thus directed to methods and apparatus for decreasing pressure in a first portion of a vessel of the cardiac structure of a patient by implanting a shunt communicating with an area outside said first portion, whereby a volume of blood sufficient to reduce pressure in said first portion is released.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: February 19, 2019
    Assignee: HemoDynamx Technologies, Ltd.
    Inventors: Gad Keren, Randy Kesten
  • Patent number: 10190215
    Abstract: Arrangements are provided for assembling multiple substrates for coating within a fluidized bed coater so as to deposit a coating of uniform thickness across the entire exterior surface thereof. One embodiment includes a method for coating orthopedic implants having convex and concave surfaces with pyrocarbon by pyrolytic decomposition of a hydrocarbon.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: January 29, 2019
    Assignee: On-X Life Technologies, Inc.
    Inventors: Mark E. Seeley, Fletcher Derek Southard, Mike James Mewhort, Joseph Earl Robinson, Roger William Leikam, Jeff Wayne Stark, Brett A. Bickerton, Jonathan C. Stupka, David Wilde
  • Patent number: 10139163
    Abstract: A coating device for coating a medical device with a drug-eluting material uses an in-process drying station between coats to improve a drug release profile. The drying station includes a heat nozzle configured for applying a uniform drying gas. A coating process using the dryer includes a closed-loop control for the gas between drying steps and an improved nozzle for producing more consistent spray patterns.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: November 27, 2018
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Matthew J. Gillick, John E. Papp, Kevin Seiki, Hung Nguyen
  • Patent number: 9968717
    Abstract: Disclosed is a stent with a drug coating for preventing and treating restenosis, comprising a stent and a drug coating covering the surface of the stent. The active ingredients in the drug coating are guaiane sesquiterpene compounds P1, P2 and P3. P1 is Zedoalactone B, P2 is a stereoisomer of P1, and P3 is Zedoarondiol. Compared with an existing sirolimus eluting stent, the present drug eluting stent can inhibit the intimal hyperplasia and the inflammatory reactions of vascular walls, and promote the endothelialization of blood vessels after the stent is implanted, and thus can prevent the long-term thrombotic complications; and has the advantages of small dosage, low cost, and no toxic side effect.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: May 15, 2018
    Assignee: Xiyuan Hospital of China Academy of Chinese Medical Sciences
    Inventors: Dazhuo Shi, Jiangang Liu, Fuhai Zhao, Xin Wang, Dawu Zhang, Peili Wang, Jianpeng Du, Yuanyuan Cui, Lei Zhang, Kai Cui, Zhengcai Zhang
  • Patent number: 9943670
    Abstract: The present invention is thus directed to methods and apparatus for decreasing pressure in a first portion of a vessel of the cardiac structure of a patient by implanting a shunt communicating with an area outside said first portion, whereby a volume of blood sufficient to reduce pressure in said first portion is released.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: April 17, 2018
    Assignee: V-Wave Ltd.
    Inventors: Gad Keren, Randy Kesten
  • Patent number: 9908138
    Abstract: Disclosed are stent holding devices having a support mandrel and one or more stent retaining fixtures disposed on the mandrel. The retaining fixture may include a character identifier to facilitate tracking a stent mounted on the holding device. The retaining fixture may include a conical protrusion and a conical recess to allow any number of retaining fixtures to engage each other and be stacked on the mandrel. The retaining fixture may include a tubular member having a spiral cut that enables the diameter of the tubular member to be adjusted to allow for a frictional fit on the mandrel. The retaining fixture may have a Z-shaped or T-shaped structure configured to retain a stent. The stent retaining fixture may also have a filament for retaining a stent.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: March 6, 2018
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Isaac Rodriguez-Mejia Plans, Javier Palomar Moreno, Tomás Madden, David O'Neill, Victoria May Gong
  • Patent number: 9901955
    Abstract: A balloon coating method is disclosed, which includes an application step in which, where a flexible dispensing tube for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion for discharging the coating solution therethrough and when the opening portion-formed end portion side of the dispensing tube is kept in contact with the outer surface of the balloon in such a manner as to be oriented in a direction opposite to a rotating direction of the balloon while the balloon is rotated about an axis of the balloon, the coating solution is discharged through the opening portion and applied to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction X of the balloon.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: February 27, 2018
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Hiroshi Goto, Eisuke Furuichi
  • Patent number: 9827401
    Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: November 28, 2017
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Andrew G. Bach, Mark MacGregor
  • Patent number: 9808559
    Abstract: The invention relates to a method for coating a vascular endoprosthesis, wherein the outside of the vascular endoprosthesis is wetted at least partially with a first solution of an active substance, the vascular endoprosthesis is moved in a rotational movement about the longitudinal axis of the vascular endoprosthesis, and a radially acting mechanical force is applied to the outside of the vascular endoprosthesis. The rotational movement has the effect that the solution is carried outward by the centrifugal force, such that no active substance deposits in the interior of the vascular endoprosthesis. The application of a mechanical force to the outside of the vascular endoprosthesis then has the effect of creating crystallization nuclei, such that the active substance can crystallize out.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: November 7, 2017
    Assignees: Aachen Scientific International PTE. LTD.
    Inventor: Alexander Ruebben
  • Patent number: 9744033
    Abstract: A leaflet for a prosthetic valve formed of at least one layer that includes a composite material containing at least one expanded fluoropolymer membrane having serpentine fibrils and an elastomer is provided. The fluoropolymer may be polytetrafluoroethylene. In at least one embodiment, the elastic properties are present in an axial direction the leaflet. The leaflets may be single layered or multi-layered. The leaflets may be coupled to a support structure and movable between open and closed configurations relative to the support structure to form a heart valve. The elasticity within the leaflets permits, among other things, the leaflets to bend with a reduced occurrence of wrinkles as the valve opens and closes. The elastic properties of the leaflet also, among other things, improve bending properties and reduce closure stresses, thereby extending the life of the leaflet.
    Type: Grant
    Filed: February 17, 2014
    Date of Patent: August 29, 2017
    Assignee: W.L. GORE & ASSOCIATES, Inc.
    Inventors: William C. Bruchman, Charles F. White
  • Patent number: 9739693
    Abstract: A soil analysis device is configured to create a soil sample solution. The device includes a reservoir configured to store an extractant, a mixing chamber coupled to the reservoir and configured to receive extractant from the reservoir and to receive a raw soil sample, and a control system. The control system is configured to determine an amount of extractant needed to produce, from the raw soil sample, a soil sample solution with a particular soil-to-extractant ratio and configured to cause the determined amount of extractant to be transferred from the reservoir to the mixing chamber.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: August 22, 2017
    Assignee: MONSANTO TECHNOLOGY LLC
    Inventors: Justin S. White, Stephen D. Prouty, Michael J. Preiner, Nicholas C. Koshnick
  • Patent number: 9615948
    Abstract: The drug eluting folded stent and a stent delivery system, which includes a stent having a plurality of struts interconnected to form a tubular body. At least one of the struts includes a U-shaped strut having in cross-section a first leg, a second leg, and a closed end connecting the first leg and the second leg, wherein the first leg, the second leg, and the closed end define a recess having a drug release opening opposite the closed end; and a drug coating disposed on the first leg, the second leg, and the closed end within the recess. The drug release opening is sized to release a drug from the drug coating at a predetermined drug elution rate.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: April 11, 2017
    Assignee: Medtronic Vascular, Inc.
    Inventor: Robert Melder
  • Patent number: 9566371
    Abstract: The disclosure provides biodegradable implantable devices such as a stent comprising a biodegradable polymeric wherein the polymeric material is treated to control crystallinity and/or Tg. The stent is capable to expand at body temperature in a body lumen from a crimped configuration to a deployed diameter and have sufficient strength to support a body lumen.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: February 14, 2017
    Assignee: Elixir Medical Corporation
    Inventors: Xiaoxia Zheng, John Yan, Vinayak Bhat
  • Patent number: 9548215
    Abstract: An endoprosthesis, a method for imaging an endoprosthesis, a method of making an endoprosthesis involve a polymeric substrate that has been modified to have voids embedded within the substrate. The voids are sized to scatter optical radiation from within the substrate so that an optical coherence tomography (OCT) image can be obtained in which an interior region of the substrate can be easily differentiated from empty space and other structures that surround the endoprosthesis. The voids allow for OCT visualization of the polymeric substrate which may be difficult to visualize by other methods such as fluoroscopy.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: January 17, 2017
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Mary Beth Kossuth, Richard J. Rapoza, Joel Harrington
  • Patent number: 9354159
    Abstract: An image sensor integrated circuit may contain image sensor pixels. A channel for receiving a fluid with samples may be formed on top of the image sensor. The image sensor pixels may form light sensors and imagers. The imagers may gather images of the samples as the fluid passes over the imagers or when the samples from the fluid adhere to the surface above an imager array. A protective coating may be formed on surfaces of the channel to protect the image sensor pixels and integrated circuit from potentially damaging materials in the fluid, samples, or materials provided for evaluating the samples. The protective coating may be a base-resistant material such as a silylating agent. A cover glass may be attached above the image sensor integrated circuit to form a portion of the channel. The protective coating may be formed on surfaces of the cover glass.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: May 31, 2016
    Assignee: NanoScopia (Cayman), Inc.
    Inventor: Brian Vaartstra
  • Patent number: 9204980
    Abstract: A coating device for coating a medical device with a drug-eluting material uses an in-process drying station between coats to improve a drug release profile. The drying station includes a heat nozzle configured for applying a uniform drying gas. A coating process using the dryer includes a closed-loop control for the gas between drying steps and an improved nozzle for producing more consistent spray patterns.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: December 8, 2015
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Matthew J. Gillick, John E. Papp, Kevin Seiki, Hung Nguyen
  • Patent number: 9168159
    Abstract: Devices and methods for controlling the flaking of coating fragments from medical implants and improving the delivery of therapeutic agents from such coatings are described.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: October 27, 2015
    Assignee: Biosensors International Group, Ltd.
    Inventors: Shih-Horng Su, Fuh-Sheng Chen, Debashis Dutta
  • Patent number: 9119905
    Abstract: The disclosure provides biodegradable implantable devices such as a stent comprising a biodegradable polymeric wherein the polymeric material is treated to control crystallinity and/or Tg. The stent is capable to expand at body temperature in a body lumen from a crimped configuration to a deployed diameter and have sufficient strength to support a body lumen.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: September 1, 2015
    Assignee: ELIXIR MEDICAL CORPORATION
    Inventors: Xiaoxia Zheng, John Yan, Vinayak Bhat
  • Patent number: 9114032
    Abstract: A method of making a stent includes a three-dimensional printer receiving a dataset corresponding to a three-dimensional precursor stent. The three-dimensional printer forms a precursor stent. The precursor stent comprises a plurality of bands disposed adjacent to each other, wherein each band comprises a plurality of struts connected by a plurality of crowns, and a plurality of connectors connecting each band to an adjacent band. The precursor stent is processed to remove a selected number of the plurality of connectors between adjacent bands such that at least one connector between each set of adjacent bands is removed. In an embodiment, only one connector remains between each adjacent band after the selected number of connectors have been removed.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: August 25, 2015
    Assignee: Medtronic Vascular, Inc.
    Inventor: Syamala Rani Pulugurtha
  • Publication number: 20150144262
    Abstract: Methods are provided to make a prosthetic valve having a thin, biocompatible, high-strength, composite material. In one aspect, the composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as a heart valve leaflet. The composite material includes a porous expanded fluoropolymer membrane and an elastomer, wherein the elastomer is present in the pores of the porous expanded fluoropolymer.
    Type: Application
    Filed: January 16, 2015
    Publication date: May 28, 2015
    Inventors: William C. Bruchman, Paul D. Gassler, Cody L. Hartman, Peter J. Walsh
  • Patent number: 9040111
    Abstract: A method of making a stent, including preparing a solution containing a composition, the composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, including argatroban, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 3:7, the composition dissolved in a solvent selected from the group consisting of a mixture of a lower alkyl ketone and methanol, a mixture of a lower alkyl ester and methanol or a mixture of a lower halogenated hydrocarbon and methanol; coating at least an outer surface of a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces; and after the coating, removing the solvent to complete a first coated layer.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: May 26, 2015
    Assignees: JAPAN STENT TECHNOLOGY CO., LTD., TOKAI UNIVERSITY EDUCATIONAL SYSTEM, TOYO ADVANCED TECHNOLOGIES CO., LTD.
    Inventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
  • Patent number: 9034414
    Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: May 19, 2015
    Assignees: KYOCERA MEDICAL CORPORATION, THE UNIVERSITY OF TOKYO, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara, Yasuhiko Iwasaki, Toru Moro, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Tomohiro Konno, Noboru Yamawaki
  • Publication number: 20150132357
    Abstract: The present invention relates to a process for reducing solvent contents in drug-containing polymeric compositions. Specifically, the solvent contents in the drug-containing polymeric compositions are first reduced by one or more conventional drying methods, to a range from about 0.5 wt % to about 10 wt % of the total weight of the polymeric composition. Subsequently, the drug-containing polymeric compositions are further treated by one or more low temperature (i.e., having processing temperatures of less than 60° C.) drying methods for further reduction of the solvent content to less than 10,000 ppm.
    Type: Application
    Filed: January 14, 2015
    Publication date: May 14, 2015
    Inventors: Vipul Dave, Murty N. Vyakamam, Qiang Zhang
  • Publication number: 20150125510
    Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.
    Type: Application
    Filed: August 22, 2012
    Publication date: May 7, 2015
    Inventors: Sean R. Kirkpatrick, Richard C. Svrluga, Stephen M. Blinn
  • Publication number: 20150118268
    Abstract: A metal-organic compound containing polymer matrix includes a polymer and a three-dimensional metal-organic framework includes a polydentate organic linker. The metal-organic compound containing polymer matrix is configured to continuously produce nitric oxide when exposed to a physiological fluid including a nitric oxide-releasing compound via a catalytic reaction catalyzed by the three-dimensional metal-organic framework.
    Type: Application
    Filed: January 15, 2015
    Publication date: April 30, 2015
    Inventors: Melissa M. Reynolds, Benjamin P. Reynolds
  • Publication number: 20150118649
    Abstract: The present invention relates to a surface treatment method for an implant, comprising: providing an implant; and forming a ceramic layer on a surface of the implant by atomic layer deposition, wherein the ceramic layer has a thickness of 5-150 nm; a root mean square roughness increase in a range of 15 nm or less; and a friction coefficient of 0.1-0.5. The ceramic layer formed on the surface of the implant can fully encapsulate the surface of the implant with excellent uniformity to effectively block the free metal ions dissociated from the implant. Moreover, it has anti-oxidation and anti-corrosion effects, and greatly enhances the biocompatibility of the implant.
    Type: Application
    Filed: May 20, 2014
    Publication date: April 30, 2015
    Applicant: National Taiwan University
    Inventors: Sheng-Hao HSU, Wan-Yu TSENG, Li-Deh LIN, Ming-Shu LEE, Ming-Hung TSENG, Wei-Fang SU, Feng-Yu TSAI, Min-Huey CHEN
  • Publication number: 20150109573
    Abstract: A functionalized polymer system is described herein for preparing and/or modifying biological implants and prostheses. In one aspect, the polymer system once applied to the surface of a biological implant or prosthesis, or once used in preparing a biological implant or prosthesis comprises a surface that is more hydrophilic, more wettable, more comfortable, resists cell adhesion, resists protein deposition, or a combination thereof. In one embodiment, a coated biological implant or prosthetic is described herein. The coated biological implant or prosthetic comprises a substrate forming the basic structure of the implant or prosthetic, and a coating comprising a polymer, where the coating is capable of resisting cell adhesion, protein deposition, or a combination thereof.
    Type: Application
    Filed: May 3, 2013
    Publication date: April 23, 2015
    Inventor: Dong Xie
  • Patent number: 9005696
    Abstract: A bone implantable medical device made from a biocompatible material, preferably comprising titania or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of ion beam irradiation, preferably gas cluster ion beam irradiation for improving bone integration.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: April 14, 2015
    Assignee: Exogenesis Corporation
    Inventors: Richard C. Svrluga, Laurence B. Tarrant
  • Patent number: 9005695
    Abstract: An endoprosthesis comprising a stent, a cover fully covering the stent wherein the cover has variable porosity in the radial direction; and an adhesion layer connecting the stent to the cover. Another aspect of the invention is a method of implanting an endoprosthesis which includes a stent, providing a cover with variable porosity in the radial direction, connecting the stent to the cover with an adhesion layer to form a covered stent, and implanting the covered stent within a body lumen of a patient.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: April 14, 2015
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Peter J. Shank, Sheng-Ping Zhong, Kinh-Luan D. Dao, F. Anthony Headley, Jr.
  • Publication number: 20150099056
    Abstract: Coatings are provided in which surfaces may be activated by covalently bonding a combination of silane derivatives (A) to the metal surface, covalently bonding a lactone polymer (B) to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester (C) on the bonded lactone polymer. Biologically active agents or therapeutic compounds may be deposited with any of the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
    Type: Application
    Filed: December 15, 2014
    Publication date: April 9, 2015
    Inventor: Jonathon Z. Zhao
  • Patent number: 8998679
    Abstract: Methods of treating the polymeric surfaces of a stent with a fluid including a solvent for the surface polymer are disclosed.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: April 7, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Bin Huang, David C. Gale, Daniel Castro, Timothy A. Limon
  • Publication number: 20150093496
    Abstract: Medical device coatings are provided that simultaneously release a therapeutic agent at different rates from different portions of the medical device coating. In a first embodiment, medical device coatings are provided that include particles comprising a therapeutic agent with two or more different particles sizes within a single layer on a surface of the implantable device. In a second embodiment, medical device coatings are provided having a higher concentration of the therapeutic agent in a first region of the coating than in a second region of the coating. In a third embodiment, medical device coatings are provided that are formed by certain coating processes wherein the droplet size of a spray coating solution is changed during the coating process. These coating processes preferably include applying a solution comprising a therapeutic agent and a suitable solvent to a surface of an implantable medical device.
    Type: Application
    Filed: December 9, 2014
    Publication date: April 2, 2015
    Applicant: COOK MEDICAL TECHNOLOGIES LLC
    Inventors: William F. Moore, Gary Bradford Shirley
  • Patent number: 8986775
    Abstract: A system for delivery of a beneficial agent in the form of a viscous liquid or paste allows holes in a medical device to be loaded in a single step process. The loading of a beneficial agent in a paste form also provides the ability to deliver large and potentially sensitive molecules including proteins, enzymes, antibodies, antisense, ribozymes, gene/vector constructs, and cells including endothelial cells.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: March 24, 2015
    Assignee: Innovational Holdings LLC
    Inventors: John F. Shanley, Stephen Hunter Diaz, Theodore L. Parker
  • Publication number: 20150079142
    Abstract: Methods for inhibiting a biomaterial-associated thrombotic event comprise reducing the number of platelets that bind to the biomaterial, or inhibiting platelet activation, by attaching CD47 or the Ig domain thereof to the surface of the biomaterial. Methods of the present invention inhibit thrombi formation on or near a biomaterial that is on the surface of an implant, medical device, tube, or therapeutic delivery vehicle. Also provided are kits for practicing these methods and the modified biomaterials.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 19, 2015
    Inventors: Stanley J. Stachelek, Matthew J. Finley, Robert J. Levy
  • Publication number: 20150080940
    Abstract: Described are embolization devices which carry M1 macrophage promoting agents and/or M2 macrophage inhibiting agents, as well as methods for their manufacture and use. An illustrative embolization device of the disclosure comprises an embolic body and one or more M1 macrophage promoting agents and/or M2 macrophage inhibiting agents carried by a surface of the embolic body. In certain embodiments the embolic body of the present disclosure comprises an embolic coil or an embolic bead.
    Type: Application
    Filed: August 27, 2014
    Publication date: March 19, 2015
    Inventor: Colleen Gemborys
  • Patent number: 8980364
    Abstract: Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: March 17, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Yung-Ming Chen, Jason Van Sciver, Syed F. A. Hossainy, Stephen D. Pacetti
  • Publication number: 20150073529
    Abstract: An endoprosthesis, such as a stent, having anti-migration features. The endoprosthesis includes an expandable tubular framework including a plurality of strut rows and a plurality of connectors extending across interstices between adjacent strut rows and interconnecting adjacent strut rows. The strut rows have an outer diameter in an expanded state and the connectors extend radially outward beyond the outer diameter of the strut rows in the expanded state. The connectors are configured to engage a wall of a body lumen in the expanded state to inhibit migration of the endoprosthesis in the body lumen. The endoprosthesis may include a polymeric cover covering the strut rows and spanning the interstices between adjacent strut rows, while a space between the connectors and the strut rows to which the connectors are interconnected with is devoid of the polymeric cover to permit tissue ingrowth around the connectors.
    Type: Application
    Filed: September 11, 2014
    Publication date: March 12, 2015
    Inventors: Sean P. Fleury, Dane T. Seddon, Daniel Ross, Burns P. Doran
  • Publication number: 20150071984
    Abstract: Controlled release vascular implants, such as vascular grafts, stents, wraps, and gels comprising a biocompatible polymer and all trans retinoic acid (ATRA), or its derivatives, can be used to treat, prevent, or inhibit thrombosis and/or neointimal hyperplasia which may otherwise be induced by prosthetic implantation. In particular, the implants herein can inhibit smooth muscle cell proliferation, neointimal hyperplasia, and upregulate antithrombotic genes and nitric oxide production in the vasculature. Further, the implants are capable of delivering controlled and predictable localized concentrations of ATRA.
    Type: Application
    Filed: November 18, 2014
    Publication date: March 12, 2015
    Inventors: Guillermo A. Ameer, Melina Kibbe, Antonio Webb
  • Patent number: 8974521
    Abstract: An implant having a preferably hollow cylindrical main structure comprising a large number of continuous openings and a coating which releases at least one pharmaceutically active substance. To attain a better distribution of the pharmaceutically active substance, at least 20% of the cross-sectional area, preferably at least 50% of the cross-sectional area, of at least a portion of the openings in a predetermined section of the main structure is covered with the coating which releases at least one pharmaceutically active substance. Furthermore, a system composed of a catheter and such an implant, a simple method for manufacturing such an implant or such a system is provided.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: March 10, 2015
    Assignee: Biotronik AG
    Inventors: Tobias Diener, Elisabeta Burean, Matthias Fringes
  • Patent number: 8968765
    Abstract: The present disclosure provides a brush polymer, including: a linear polymer main chain; and brush structural side chains, including: a hydrophobic molecular branch, and a hydrophilic molecular branch and/or an anti-biofilm/or an anti-microbial molecular branch, wherein the linear polymer main chain is conjugated to the side chains by covalent bonds formed between a hydroxyl group and a reactive functional group, wherein the reactive functional group includes: isocyanate, carboxyl, or epoxy. The present disclosure also provides a medical application of the brush polymer.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: March 3, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: Jui-Hsiang Chen, Jean-Dean Yang, Yu-Hua Chen, Ting-Yu Shih, Chia-wei Hong, Chao-Chen Tien
  • Patent number: 8968392
    Abstract: A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: March 3, 2015
    Assignees: Japan Stent Technology Co., Ltd., Tokai University Educational System, Toyo Advanced Technologies Co., Ltd., Hiroo Iwata
    Inventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
  • Patent number: 8961588
    Abstract: A method of coating a stent is presented such that less than 50% of the total amount of 40-O-(2-hydroxyl)ethyl-rapamycin, or an analog or derivative thereof, is released in vivo in a 24 hour period, wherein the method comprises exposing the coating to sufficient temperature to modify the structure of the polymer.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: February 24, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Gordon Stewart, Mark A. Williams, Jeff Royal, Paul M. Consigny, Dorie M. Happ, Kurt Scheinpflug, Ty Hu
  • Patent number: 8962064
    Abstract: Described is a process for producing pulverulent, antioxidant-comprising coating compositions, comprising providing an aqueous polymer dispersions comprising one or more antioxidants and a polymer obtained by radical polymerization of a) N,N-diethylaminoethyl methacrylate, and b) at least one radically polymerizable compound selected from esters of ?,?-ethylenically unsaturated mono- and dicarboxylic acids with C1-C8-alkanols, wherein the antioxidants are incorporated into the aqueous polymer dispersion in the form of a solution or of a dispersion, and spray processing the aqueous polymer dispersion to provide a powder form.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: February 24, 2015
    Assignee: BASF SE
    Inventors: Karl Kolter, Maximilian Angel, Bernhard Linner
  • Patent number: 8951221
    Abstract: The invention relates to a method and device for the treatment of glaucoma, though insertion of an implant into the lumen of the Schlemm's canal to realize proper drainage of the aqueous humor, which implant is brought into its position in the Schlemm's canal by means of a catheter having a distal and a proximate portion and provided with a number of pores through which a gaseous or fluid medium which comes from a pressure source can emerge during insertion of the catheter carrying the implant into the Schlemm's canal, and while the catheter is being inserted into the Schlemm's canal the gaseous or fluid medium is released under pressure thereby expanding the Schlemm's canal and the implant and upon releasing the implant at its determined location, the catheter can be withdrawn from the Schlemm's canal.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: February 10, 2015
    Assignee: Grieshaber Ophthalmic Research Foundation
    Inventors: Robert Christopher Stegmann, Matthias Christian Grieshaber, Hans Rudolf Grieshaber
  • Publication number: 20150037493
    Abstract: A stent-graft, including a generally tubular vascular graft of biocompatible material, and a plurality of bio-resorbable discrete annular members spaced apart along a longitudinal axis of the vascular graft and attached thereto.
    Type: Application
    Filed: October 15, 2014
    Publication date: February 5, 2015
    Inventor: JOHN D. MCDERMOTT
  • Patent number: 8945206
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: February 3, 2015
    Assignee: Cook Medical Technologies LLC
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
  • Publication number: 20150032203
    Abstract: A vascular prosthesis with an impregnation including at least one sealing material in the prosthesis wall and/or with a coating including at least one sealing material on the outer surface of the prosthesis, wherein the prosthesis, when subjected to a force of 1 N acting perpendicularly with respect to the outer surface of the prosthesis, is deformed such that the external diameter of the prosthesis decreases, in the direction of the acting force, by 60 to 100% in relation to the original external diameter.
    Type: Application
    Filed: January 24, 2013
    Publication date: January 29, 2015
    Inventors: Jan-Philip Zappe, Dietmar Probst