Implantable Permanent Prosthesis (i.e., Artificial Body Member) (e.g., Pacemaker, Lens, Cornea, Glaucoma Shunt, Heart Valve, Muscle, Spinal Disc, Breast, Internal Organ) Patents (Class 427/2.24)
  • Patent number: 10646619
    Abstract: A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and at least one closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a non-homogeneous external surface comprising individual clusters of flat crystal platelets consisting of epitactically grown HAP nanocrystals and coarse areas between the individual clusters, whereby the percentage of the coarse areas between the individual clusters as measured by SEM is at least 20% of the total surface, which material shows an increased capacity to induce bone formation, and a process of preparation thereof.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: May 12, 2020
    Assignee: GEISTLICH PHARMA AG
    Inventors: Claudio Zihlmann, Michael Bufler
  • Patent number: 10624990
    Abstract: The present application relates to bioactive implants, methods of making bioactive implants, and methods of using bioactive implants to treat or repair a bone defect or a cartilage defect. In an aspect, the present application relates to compositions comprising bone microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, the present application relates to compositions comprising cartilage microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, disclosed herein are methods of making and using the disclosed compositions comprising bone microparticles and the disclosed composition comprising cartilage microparticles. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: April 21, 2020
    Assignee: Osteolife Biomedical, LLC
    Inventor: Theodore Malinin
  • Patent number: 10617854
    Abstract: Methods and devices for trans-jugular carotid access are disclosed. Methods within the scope of this disclosure include methods of trans-jugular carotid access originating in the leg of a patient or other location remote to the jugular vein and carotid artery and methods originating at the neck of a patient. Devices used in connection with the disclosed methods may comprise access catheters, lumens, and stylets.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: April 14, 2020
    Assignee: Vascular Access Technologies, Inc.
    Inventor: Lakshmikumar Pillai
  • Patent number: 10526691
    Abstract: Provided is a nitrided metal surface functionalized with molecules, each molecule comprising at least one binding group and an antimicrobial moiety. The molecules are immobilized on the surface by only covalent interactions between the binding groups of the molecules and nitrogen atoms within the nitrided metal surface. Articles comprising the functionalized nitrided surface find use in inhibiting or reducing the growth of microorganisms on surfaces that are frequently touched. A method for preparing the functionalized nitrided surface comprises contacting a nitrided metal surface with molecules so as to form covalent bonds between the binding groups of the molecules and the nitrogen atoms in the surface, thereby immobilising the molecules on the metal surface.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: January 7, 2020
    Assignee: The University of Birmingham
    Inventor: Felicity Jane de Cogan
  • Patent number: 10519594
    Abstract: Supercritical fluid (“SCF”) is used to scour a target material to leave scour elements, such as oligomers and oils from the target material. Carbon dioxide (“CO2”) is introduced into a pressure vessel also containing the target material to be scoured. The CO2 is raised in temperature and pressure to a SCF state. The CO2 is recirculated within the pressure vessel to scour the target material. An exchange of the CO2 is occurs allowing for the scoured elements to be removed from the CO2 and therefore from within the pressure vessel. Operation variables such as temperature, pressure, time, internal flow rate, and CO2 exchange are adjusted to achieve a scouring of the target material.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: December 31, 2019
    Assignee: NIKE, Inc.
    Inventors: Matt W. Kelly, Gerardo A. Montero, Anand P. Kanchagar, Pankaj Rugnath Panchmatia
  • Patent number: 10485109
    Abstract: Flexible electrical devices comprising electrode layers on softening polymers and methods of manufacturing such devices, including lift-off processes for forming electrodes on softening polymers, processes for forming devices with a patterned double softening polymer layer, and solder reflow processes for forming electrical contacts on softening polymers.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: November 19, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Romil Modi, Jonathan Reeder, Gregory T. Ellson, Walter Voit, Alexandra Joshi Imre
  • Patent number: 10463512
    Abstract: Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: November 5, 2019
    Assignee: Medtronic Vascular, Inc.
    Inventors: Justin Peterson, James Mitchell, Abby S Pandya, Nate Glucklich, Joseph Berglund, Ya Guo
  • Patent number: 10448970
    Abstract: The present disclosure relates to the field of endovascular treatment. More particularly, the present invention uses a modified hydrogel intrasaccular occlusion device designed to implement an endovascular treatment to ameliorating or eliminating aneurysm recurrence, which hydrogel may optionally be impregnated with pharmaceutical compounds. The present invention also teaches the use of thin hydrogel coatings to ameliorate endovascular treatment related difficulties.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: October 22, 2019
    Inventor: Daniel E. Walzman
  • Patent number: 10434216
    Abstract: The present invention relates to an ultra-thin film silk fibroin/collagen composite implant for tissue engineering and a manufacturing method therefor. The ultra-thin film silk fibroin/collagen silk fibroin/collagen composite implant according to the present invention has no cytotoxicity and can minimize the influence on cell growth, due to the combined use of a refined silk fibroin aqueous solution, collagen and various biomaterials, and thus can be widely used as an ultra-thin film implant for implanting.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: October 8, 2019
    Assignee: Industrial Cooperation Foundation Chonbuk National University
    Inventors: Gil Son Khang, Eun Young Kim, Jae Won Yang, Jeong Eun Song, Se Rom Cha
  • Patent number: 10428200
    Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: October 1, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA, Northwestern University
    Inventors: Ton That Hai, John-Bruce Devault Green, Timothy Michael Fulghum, Phillip Byron Messersmith, Tadas Stanislovas Sileika
  • Patent number: 10426547
    Abstract: An optical device including an optical fiber having a longitudinal axis and an optical fiber core with a distal end having a distal terminating end configured to discharge a first laser energy in a first direction and a second laser energy in a second direction. The optical device also includes a fiber cap having an interior cavity and an opening to the interior cavity, where the distal end of the optical fiber core is received within the interior cavity through the opening. A cladding is included on the distal end of the optical fiber core between the optical fiber core and the fiber cap.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: October 1, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Thomas Charles Hasenberg, Rongwei Jason Xuan, Brian P. Watschke, Douglas Lawrence Evans, Guangjian Wang, Steven Yihlih Peng, Wen-Jui Ray Chia
  • Patent number: 10413638
    Abstract: Provided are surface-modified rubbers or surface-modified thermoplastic elastomers, such as catheters, syringe barrels, tubes of medical instruments, and mudguard fenders, and methods for modifying the surface of rubber or a thermoplastic elastomer, wherein a lubricant layer is firmly bonded to the surface of medical devices such as catheters, syringe barrels, and tubes of medical instruments to impart lubricity to the surface and, further, improve the durability of the lubricant layer on the surface, thereby suppressing deterioration of the sliding properties. Included is a surface-modified rubber or a surface-modified thermoplastic elastomer each having a surface at least partially treated by polymerization of a monomer in the presence of a thermal polymerization initiator.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: September 17, 2019
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventor: Yasuhisa Minagawa
  • Patent number: 10408821
    Abstract: Disclosed herein are devices that include a top chamber including at least one port, a bottom chamber including at least one inlet and at least one outlet, wherein the opening of the at least one inlet is smaller than the opening of the at least one outlet, and a membrane located between the top chamber and the bottom chamber, wherein the membrane is fluidly coupled with the top chamber and the bottom chamber. Also disclosed herein are systems including the disclosed devices. The systems include liquid in one or more of the chambers of the device. Methods of using the devices and systems include producing a vacuum by flowing a liquid through the bottom chamber of the system. Due to the difference in size of the inlet and outlet in the bottom chamber, a vacuum is produced in the top chamber.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: September 10, 2019
    Assignee: Triad National Security, LLC
    Inventors: Pulak Nath, Jen-Huang Huang
  • Patent number: 10279372
    Abstract: A method for forming a coating on a stent involves spraying or drying a coating on the stent while the stent is supported on a mandrel assembly, during which part of the stent is made to go out of contact with the mandrel assembly.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: May 7, 2019
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Yung-Ming Chen, Jason Van Sciver, Jeff McCabe, Antonio Garcia
  • Patent number: 10214608
    Abstract: Methods are provided for surface-modifying a rubber vulcanizate or a thermoplastic resin. The methods allow these objects to have a chemically fixed surface layer that exhibits not only low adsorption or selective adsorption properties with respect to proteins and cells, but also excellent durability, instead of having a coating which has drawbacks such as reduction in properties due to separation or peeling of the coating. Included is a method for surface-modifying an object made of a rubber vulcanizate or a thermoplastic resin, the method including: a step 1 of forming polymerization initiation points on the surface of the object; and a step 2 of radically polymerizing a hydrophilic monomer starting from the polymerization initiation points by irradiation with UV light having a wavelength of 300 to 400 nm in the presence of an alkali metal salt to grow polymer chains on the surface of the object.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: February 26, 2019
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventor: Yasuhisa Minagawa
  • Patent number: 10201637
    Abstract: Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: February 12, 2019
    Assignee: Surmodics, Inc.
    Inventors: David E. Babcock, Sean Lundquist, Gary Opperman, Adriyn Torguson, Tim Jentz
  • Patent number: 10174276
    Abstract: Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink, and support material; a UV light module for optionally exposing the contents of at least one cartridge to UV light; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Also described herein are methods of using and bioprinting cartridges for such bioprinters.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: January 8, 2019
    Assignee: Organovo, Inc.
    Inventors: Keith Murphy, Scott Dorfman, Richard Jin Law, Vivian Anne Le
  • Patent number: 10145629
    Abstract: The present disclosure is directed to a metal-containing apparatus including a substrate member constructed of a metal that is highly resistant to pitting corrosion and wear in aggressive media. An exemplary metal-containing apparatus is a plate heat exchanger. The metal includes an oxidation layer on the surface thereof and a thin metal oxide nanoporous film on top of the oxidation layer. The nanoporous film is highly compliant and is comprised of oxygen and aluminum, titanium, silicon, zirconium and combinations thereof.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: December 4, 2018
    Assignee: Wisconson Alumni Research Foundation
    Inventors: Marc A. Anderson, M. Isabel Tejedor, Ole Christensen
  • Patent number: 10058889
    Abstract: A method of forming a biocompatible or biologically inert article for use in an application in which the article will make contact with at least one tissue, organ, or fluid within a human or animal body is provided. The method generally comprises providing an article having an external surface; selecting chemical precursors; using a means to direct one or more chemical precursors towards or to apply such chemical precursors to the external surface; activating the chemical precursors by exposing said precursors to atmospheric pressure plasma; and grafting and/or cross-linking the chemical precursors to form a solid coating adjacent to the external surface of the article.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: August 28, 2018
    Assignee: Kettering University
    Inventors: Mary Gilliam, Susan Farhat, Ali Zand
  • Patent number: 10039865
    Abstract: The invention relates to a prosthetic for repairing an opening or a defect in a soft tissue, to its preparation and use. The prosthetic of the invention comprises a substrate viscerally-coated with stabilized and non-completely dry fibrin. The prosthetic displays reduced postoperative complications following its implantation.
    Type: Grant
    Filed: September 21, 2009
    Date of Patent: August 7, 2018
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Eyal Sheetrit, Israel Nur, Liliana Bar, Lior Weissman
  • Patent number: 9999595
    Abstract: The invention provides a sustained release intraocular drug delivery device comprising: (a) a polymeric matrix core into which at least one therapeutic agent is mixed, and; (b) a polymeric coating completely surrounding said polymeric matrix material; wherein said polymeric matrix core and polymeric coating are insoluble and inert in ocular fluids, and wherein said sustained release intraocular drug delivery device has a compliant annular segment shape and is to be inserted into the sulcus of the intact and/or pseudophakic eye.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: June 19, 2018
    Assignee: EYED PHARMA
    Inventors: Jean-Marie Rakic, Jean-Michel Foidart
  • Patent number: 9949480
    Abstract: The present invention provides N-alkylthio ?-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and methods of their use as anti-bacterial agents.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: April 24, 2018
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Edward Turos, Kevin D. Revell
  • Patent number: 9895468
    Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: February 20, 2018
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA, NORTHWESTERN UNIVERSITY
    Inventors: Ton That Hai, John-Bruce Devault Green, Timothy Michael Fulghum, Phillip Byron Messersmith, Tadas Stanislovas Sileika
  • Patent number: 9821091
    Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: November 21, 2017
    Assignee: Abbot Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, Fuh-Wei Tang, Lothar W. Kleiner, Thierry Glauser, Yiwen Tang, Wouter E. Roorda, Stephen D. Pacetti, Gina Zhang, Yung-Ming Chen, Andrew F. McNiven, Sean A. McNiven, Brandon J. Yoe
  • Patent number: 9809717
    Abstract: The disclosure provides polymers having antimicrobial activity and articles with the polymers coated thereon. The polymers include a first pendant group comprising a first cationic component, a second pendant group comprising a nonpolar component, and a third pendant group comprising an organosilane component. The disclosure also includes methods of coating medical device articles and body fluid-receiving substrates with the antimicrobial polymers. The methods further include the use of adhesion-promoting components.
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: November 7, 2017
    Assignee: 3M Innovative Properties Company
    Inventors: Mahfuza B. Ali, Naiyong Jing, Valeri Lirine, Pradnya V. Nagarkar, Caroline M. Ylitalo, Nancy S. Lennhoff, Matthew T. Scholz, Ranjani V. Parthasarathy
  • Patent number: 9802216
    Abstract: An automated apparatus and method for coating medical devices such as an intravascular stent, are disclosed in the method, a 2-D image of a stent is processed to determine (1) paths along the stent skeletal elements by which a stent secured to a rotating support element can be traversed by a dispenser head whose relative motion with respect to the support element is along the support-element axis, such that some or all of the stent skeletal elements will be traversed (2) the relative speeds of the dispenser head and support element as the dispenser head travels along the paths, and (3), and positions of the dispenser head with respect to a centerline of the stent elements as the dispenser head travels along such paths The rotational speed of the support and relative linear speed of the dispenser are controlled to achieve the desired coating thickness and coating coverage on the upper surfaces, and optionally, the side surfaces, of the stent elements.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: October 31, 2017
    Assignee: Biosensors International Group, Ltd.
    Inventors: Ivan Vecerina, Vinh Pham
  • Patent number: 9770576
    Abstract: Methods and apparatus for coating a medical device are provided. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: September 26, 2017
    Assignee: Lutonix, Inc.
    Inventors: Jeffrey Wang, Harrison Malinoff, Lixiao Wang, Christopher M. Barry, Dennis W. Wahr, Scott R. Naisbitt
  • Patent number: 9750839
    Abstract: Medical devices possessing coatings are provided. The coatings include at least one polyelectrolyte, capable of changing the surface charge of the device to which they are applied. The polyelectrolytes permit attachment of charged bioactive agents thereto. Multiple polyelectrolytes, possessing opposite charges, may be sequentially applied to produce a medical device having multiple layers. Methods for forming such devices are also provided.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: September 5, 2017
    Assignee: Covidien LP
    Inventor: Arpan Desai
  • Patent number: 9750853
    Abstract: This invention relates to stents, a type of implantable medical device, with an antiproliferative coating and a prohealing luminal coating and methods of fabricating stents with an antiproliferative coating and a prohealing luminal coating.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: September 5, 2017
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Bin Huang, David C. Gale, Daniel A. Castro, Vincent J. Gueriguian
  • Patent number: 9744259
    Abstract: Stent scaffolds comprising branched biocompatible polymers are disclosed.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: August 29, 2017
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Yunbing Wang, David C. Gale, Bin Huang, Mikael O. Trollsas, Thierry Glauser, Florian Ludwig
  • Patent number: 9738744
    Abstract: The present invention provides methods of modifying the surfaces of a plurality of three-dimensional objects at the same time to provide good sliding properties, good durability after repeated sliding, good sealing properties, and the like, and also provides gaskets for syringes obtained by such methods. The present invention relates to a method for modifying the surfaces of a plurality of three-dimensional objects including: a step 1 of immersing a plurality of three-dimensional objects in a photopolymerizable monomer-containing liquid; and a step 2 of polymerizing the photopolymerizable monomer by photoirradiation while rotating a vessel containing the plurality of three-dimensional objects and the photopolymerizable monomer-containing liquid, to grow polymer chains on the surfaces of the plurality of three-dimensional objects.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: August 22, 2017
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventor: Yasuhisa Minagawa
  • Patent number: 9718781
    Abstract: The invention generally relates to methods and compounds for treating proliferative disorders, viral infections, or both. In some embodiments, the invention provides an anticancer or antiviral compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating a proliferative disorder or a viral infection including administering an anticancer or antiviral compound that binds to a thromboxane receptor, has preferential binding for either TPalpha (TP?) or TPbeta (TP?) receptor subtype.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: August 1, 2017
    Assignee: UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
    Inventors: B. Therese Kinsella, Helen Reid
  • Patent number: 9662425
    Abstract: A method for loading a hydroxyapatite coated implant with a therapeutic agent including the steps of providing an implant and applying a hydroxyapatite coating on a surface of the implant. The hydroxyapatite coated implant is contacted with a solution including the therapeutic agent. The hydroxyapatite coated implant and solution is heated to temperature of about 60° C. to about 100° C. Pressure is applied to the hydroxyapatite coated implant and solution from about 2 bar to about 10 bar, to load the hydroxyapatite coated implant with the therapeutic agent. An implant made according to the method has sustained therapeutic agent delivery and includes a base and a biomimetic hydroxyapatite coating disposed on a surface thereof.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: May 30, 2017
    Assignee: Stryker European Holdings I, LLC
    Inventors: Mirjam Lilja, Jan Henrik Sörensen, Philip Procter, Hartwig Steckel, Torben Christian Sörensen
  • Patent number: 9656054
    Abstract: The implantable electrode system of the preferred embodiments includes a conductor, an interconnect coupled to the conductor, an insulator that insulates the interconnect, and an anchor that overlaps a peripheral edge of the electrode layer. The anchor is mechanically interlocked with the insulator. This structure is particularly useful with the electrode layer being a neural interface that is configured to provide either a recording and stimulating function.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: May 23, 2017
    Assignee: NEURONEXUS TECHNOLOGIES, INC.
    Inventors: David S. Pellinen, Mayurachat Ning Gulari, Jamille Farraye Hetke, David J. Anderson, Daryl R. Kipke, Rio J. Vetter
  • Patent number: 9629941
    Abstract: The present document is directed to a titanium dioxide scaffold comprising a hydrogel coating comprising a biologically active substance. Also disclosed is a method for producing a thin hydrogel coating on a titanium dioxide scaffold and uses of the hydrogel coated scaffolds as medical implants.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: April 25, 2017
    Assignee: CORTICALIS AS
    Inventors: S. Petter Lyngstadaas, Havard J. Haugen, Hanna Tiainen
  • Patent number: 9622891
    Abstract: Embodiments of the present invention encompass methods of forming coatings, particularly coatings for medical devices, and more particularly, for braided or woven medical devices. Embodiments of the present invention encompass the coatings and the coated devices. The coatings may include a polymer and optionally a therapeutic agent.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: April 18, 2017
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Benjamyn Serna, Michael Huy Ngo, Syed F. A. Hossainy, O. Mikael Trollsas
  • Patent number: 9604248
    Abstract: A coating device for coating a medical device with a drug-eluting material uses an in-process drying station between coats to improve a drug release profile. The drying station includes a heat nozzle configured for applying a uniform drying gas.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: March 28, 2017
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Charles R. Bobson, Kurt Scheinpflug, Yung-Ming Chen, Jeff H. Smith
  • Patent number: 9579491
    Abstract: A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: February 28, 2017
    Assignee: SURMODICS, INC.
    Inventors: Ralph A. Chappa, Mark F. Carlson
  • Patent number: 9572914
    Abstract: Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: February 21, 2017
    Assignee: COOK MEDICAL TECHNOLOGIES LLC
    Inventors: John Jackson, Lindsay Stuart Machan, Kevin Letchford
  • Patent number: 9549832
    Abstract: Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: January 24, 2017
    Assignee: Medtronic Vascular, Inc.
    Inventors: Justin Peterson, James Mitchell, Abby Schlichting, Nate Glucklich, Joseph Berglund, Ya Guo
  • Patent number: 9511175
    Abstract: Implantable medical devices include a substrate having applied thereto a coating including a polymeric material possessing a core and at least one functional group known to have click reactivity.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: December 6, 2016
    Assignees: Sofradim Production, Covidien LP
    Inventors: Sébastien Ladet, Ahmad Robert Hadba
  • Patent number: 9512250
    Abstract: The disclosure discloses initiating systems for the radical polymerization of alkenes, and especially fluorine substituted alkenes. The polymerization is catalyzed by a metal carbonyl, preferably manganese carbonyl. The polymerization is initiated directly from alkyl halides at room temperature under visible white light. The polymers also allow the synthesis of block copolymers. The process comprises polymerizing at least one alkene monomer in the presence of a halide radical initiator, carbonyl catalyst and a solvent, under reaction conditions and for a time sufficient to polymerize the at least one alkene monomer to form a polymer. The present disclosure provides a method for living polymerization of alkene monomers which provides a high level of macromolecular control over the polymerization process and which leads to uniform and controllable polymeric products.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: December 6, 2016
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventor: Alexandru D. Asandei
  • Patent number: 9464342
    Abstract: A method for manufacturing a high ductility Ti-, Ti-alloy or NiTi-foam, meaning a compression strain higher than 10%, includes: preparing a powder suspension of a Ti-, NiTi- or Ti-alloy powder, bringing the said powder suspension into a desired form by gelcasting to form a green artifact. The method also includes a calcination step wherein the green artifact is calcined, and sintering the artifact. The calcination step includes a slow heating step wherein said green artifact is heated at a rate lower or equal to 20° C./hour to a temperature between 400° C. and 600° C. and the Ti-, NiTi- or Ti-alloy powder has a particle size less than 100 ?m. A high ductility Ti-, Ti-alloy or NiTi foam, with a compression higher than 10%, with a theoretical density less than 30%, pore size (cell size) between 50 to 1000 ?m can be obtained with such a method.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: October 11, 2016
    Assignee: VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK (VITO)
    Inventors: Steven Mullens, Ivo Thijs, Jozef Cooymans, Jan Luyten
  • Patent number: 9456823
    Abstract: Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations of the vasculature with radiopaque hydrogel filaments with delayed controlled rates of expansion. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: October 4, 2016
    Assignee: Terumo Corporation
    Inventors: Michael Constant, Josh Garretson, Gregory M. Cruise
  • Patent number: 9422622
    Abstract: Thin conductive metal coatings suitable for flexible nonmetal fine wires and leads are described. Polymer clad silica fiber cores are produced by plasma coating with single or dual layers of metals such as silver, gold or titanium to provide micro thin leads such as those used for pacemakers and fracture resistant aircraft wires that are both conductive and resistant to flexing breakage. The metal surfaces can be used to transmit analog signals while the nonmetal cores can be designed to transmit digital signals. Select deposition conditions can produce nanorough metal coating surfaces which promote cell adhesion so that tissue scarring in vivo is greatly reduced.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: August 23, 2016
    Assignee: SURFATEK LLC
    Inventor: Daniel M. Storey
  • Patent number: 9415416
    Abstract: A systems and method for reducing coating defects on a stent may involve a support apparatus comprising wire cage for carrying a stent. The support apparatus may have no structure that extends inside the stent. A support apparatus may include a plurality of wires that pass through the stent but do not pass through the midplane of the stent. A support apparatus may contact only the proximal ends of the stent. The method may involve keeping the stent in motion during a spray coating process to prevent the stent from having a point remain in continuous contact with a support apparatus.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: August 16, 2016
    Assignee: Abbott Cardiovascular Systems, Inc.
    Inventors: Stephen D. Pacetti, Laura Melton Kalvass
  • Patent number: 9408692
    Abstract: A silicone prosthesis including a silicone shell, which has superior texture and comfort when implanted in the body, minimizes stress concentration that may arise when wearing for a long time by eliminating the difference in physical characteristics and stress in all parts of the shell, due to the silicone prosthesis having a uniform thickness, increases resistance to fatigue fracture so as to maximize the safety and lifespan of the silicone prosthesis, and which controls the flow of the silicone in various angles, thereby providing a round or an anatomical type silicone prosthesis having a shell with enhanced durability and a uniform thickness.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: August 9, 2016
    Inventor: Won Seok Yu
  • Patent number: 9398968
    Abstract: A method for loading a medical appliance with a medicament and/or a polymer is disclosed, the medical appliance comprising one or more grooves or holes loaded with the medicament and/or polymer. The method comprising the steps of: 1) capturing an image of the grooves or holes of the medical appliance, wherein the image contains at least one complete pattern of the grooves or holes; 2) performing digital image processing on the captured image to obtain the pattern of the grooves or holes; 3) calculating a central position of the pattern of the grooves or holes, and determining an actual central position of the grooves or holes based on the central position; 4) adjusting a relative position of a loading device to the medical appliance to align an outlet of the loading device with the actual central position of the grooves or holes; and 5) opening the outlet of the loading device to load the grooves or holes. A device for loading a medical appliance with a medicament and/or a polymer is further disclosed.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: July 26, 2016
    Assignee: SHANGHAI MICROPORT MEDICAL (GROUP) CO., LTD.
    Inventors: Jie Zhang, Bo Yi, Changsheng Wu, Zhirong Tang, Qiyi Luo
  • Patent number: 9397359
    Abstract: The invention relates to a method for preparing a material based on metal element(s) oxide(s) on a substrate, comprising the following successive steps: a) depositing, by liquid means, on at least one face of this substrate, at least one layer of a sol-gel precursor solution of the constituent metal element(s) oxide(s) of said material; b) depositing, by liquid means, on said layer deposited in a), at least one layer of a dispersion comprising a powder of metal element(s) oxide(s) and a sol-gel solution identical to or different from that used in step a), said solution being a precursor of the constituent metal element(s) oxide(s) of said material and the powder consisting of constituent metal element(s) oxide(s) of said material; c) heat treating said layers deposited in a) and b) in order to transform them into said material.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: July 19, 2016
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Philippe Boy, Emilie Courtin, Thierry Piquero, Agnès Biller
  • Patent number: 9393106
    Abstract: A soft prosthetic implant shell, such as a silicone breast implant shell, that has discrete fixation surfaces thereon for tissue adhesion. The fixation surfaces may be provided on the posterior face of the shell, as well as either on the periphery or at discrete areas on the anterior face. Band-shaped fixation surfaces may be provided on the anterior face of the shell to generally match the angle of pectoralis major or pectoralis minor muscle groups. The fixation surfaces may be roughened areas of the shell, or may be separate elements adhered to the shell.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: July 19, 2016
    Assignee: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Thomas E. Powell