Implantable Permanent Prosthesis (i.e., Artificial Body Member) (e.g., Pacemaker, Lens, Cornea, Glaucoma Shunt, Heart Valve, Muscle, Spinal Disc, Breast, Internal Organ) Patents (Class 427/2.24)
  • Patent number: 11058799
    Abstract: An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: July 13, 2021
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Rajendra Kasinath, Craig Ernsberger, Stephanie Vass, Steven N. Ginn, Haibo Qu, Weidong Tong
  • Patent number: 11058805
    Abstract: Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound. Other aspects provide methods of manufacturing and using such compositions and devices.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: July 13, 2021
    Assignee: Cook Medical Technologies LLC
    Inventors: John Jackson, Lindsay Stuart Machan, Kevin Letchford
  • Patent number: 11021586
    Abstract: The present disclosure relates to an apparatus and a method for manufacturing a channel-coupled scaffold. The present disclosure provides a method for manufacturing a channel-coupled scaffold, which includes: (1) a step of compressing a first elastic substrate which includes a groove on the surface of the substrate to close the groove; (2) a step of loading a scaffold composition onto the closed groove; and (3) a step of restoring the elastic substrate. The present disclosure also provides an apparatus for manufacturing a channel-coupled scaffold, which includes: a first elastic substrate which includes a groove on the surface of the substrate and onto which a scaffold composition is loaded: and a compression module which compresses the width of the groove of the elastic substrate to close it. The apparatus or method may accumulate a microchannel controlling local mass transfer, and align a collagen fiber in the scaffold at the same time.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: June 1, 2021
    Assignee: Korea Institute of Science and Technology
    Inventors: Nakwon Choi, Sohyun Kim, Sohyeon Jeong, Eui Sung Yoon, Changjoon Justin Lee, Il-Joo Cho
  • Patent number: 10978277
    Abstract: An apparatus for plasma treatment of an implant prior to installing the implant in a live subject is provided. The apparatus comprises an activation device and a portable container detachable from the activation device. The portable container comprises a closed compartment containing the implant immersed in a fluid, and the activation device comprises a slot configured to receive the portable container. The activation device further comprises an electrical circuit configured to be electrically associated with at least one electrode and configured to provide to the at least one electrode electric power suitable for applying a plasma generating electric field in the closed compartment, when the portable container is disposed in the slot. A container suitable for providing plasma treatment to a silicone implant and a method for preparing an implant for implantation surgery are also provided.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: April 13, 2021
    Assignee: NOVA PLASMA LTD.
    Inventors: Amnon Lam, Aviad Harhol, Eliezer Fuchs, Chen Porat
  • Patent number: 10973951
    Abstract: A method of grafting a bioactive polymer on implants, the method comprising the following steps: a) mounting implants on a support structure; b) dipping the implants in a bath of acid; c) rinsing the implants; b) dipping the implants in an anodizing bath so as to anodize them; e) rinsing the implants; f) putting the implants into a polymerization chamber; g) mounting the implants on an elevator present in the chamber; h) actuating the elevator so as to dip the implants into a polymerization bath; i) subjecting the polymerization bath to a polymerization catalyst; j) raising the elevator from the polymerization bath; k) removing the implants from the elevator; l) extracting the implants from the chamber; m) washing the implants so as to remove any excess non-grafted bioactive polymer therefrom; and n) drying the grafted implants.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: April 13, 2021
    Assignee: LES LABORATOIRES OSTEAL MEDICAL
    Inventors: Daniel Blanquaert, Bertrand De Lambert
  • Patent number: 10946414
    Abstract: A method for core impregnation of a finished part made of plastic material with an additive, including: dissolving the additive in a liquid medium to form a solution; placing the plastic part at ambient pressure in a pressure enclosure; hermetically sealing the chamber; impregnating the plastic part with the solution by a fluid at supercritical or near supercritical conditions in the enclosure at a pressure between 3 MPa and 6 MPa, at a temperature between 25° C. and 65° C. for a duration between 1 minute and 15 minutes; releasing the pressure inside the enclosure so that the liquid medium diffuses outside the plastic part and to trap the additive inside the plastic part.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: March 16, 2021
    Assignee: The Swatch Group Research and Development Ltd.
    Inventor: Nicolas Francois
  • Patent number: 10920092
    Abstract: An antibacterial device is disclosed that includes a substrate and an antibacterial coating or antibacterial surface being provided on at least a part of the substrate's surface. The antibacterial coating or surface includes Angstrom scale flakes, where the Angstrom scale flakes are arranged in a standing position on the substrate surface and are attached to the substrate surface via edge sides thereof. The Angstrom scale flakes can, for example, be graphene flakes, or graphite flakes having a thickness of a few atom layers. It has been found that such standing flakes are efficient in killing prokaryotic cells but do not harm eukaryotic cells.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: February 16, 2021
    Assignee: DENTSPLY IH AB
    Inventors: Martin Lovmar, Santosh Pandit, Venkata R. S. S. Mokkapati, Jie Sun
  • Patent number: 10898619
    Abstract: The present invention relates to an ocular device for regulating intraocular fluid pressure comprising or consisting of a tubular body wherein the inner surface of the tubular body or the inner and outer surface is/are coated with covalently immobilized hyaluronic acid (HA). In more specific embodiments, the tubular body comprises or consists of a biocompatible material selected from the group comprising a biocompatible metal such as titanium, ceramics, glass, polymers and composites thereof, and the immobilized hyaluronic acid molecules are linked with further HA molecules to form a HA hydrogel. The ocular device is a stent free from mechanical valves or other mechanical means for actively regulating the flow of intraocular fluid.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: January 26, 2021
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.
    Inventors: Joachim P. Spatz, Fania Geiger, Michael Thaller, Christian Lingenfelder, Heike Boehm
  • Patent number: 10889898
    Abstract: The present invention discloses a method for improving the blood compatibility of a material surface by using a controllable grafting technique. The method involves placing a monomer NVP, an RAFT reagent and a solvent acetonitrile in a container, adding an initiator AIBN, mixing the same uniformly, removing oxygen with liquid nitrogen, making the same react in an oil bath; after polymerization, adding liquid nitrogen to quench and stop the reaction, thus obtaining PVP-COOH; mixing the PVP-COOH with DCC and NHS; adding dry dichloromethane to the mixture in a nitrogen atmosphere, adding mercaptoethylamine, and making the same react in darkness at room temperature; obtaining a crude sample; dissolving the crude sample in water, and performing dialysis with deoxygenated water in darkness, and then obtaining HS-PVP by freeze-drying. An Au—S bond chemisorption method is used to controllably graft an anti-protein high-molecular polymer onto an Au surface.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: January 12, 2021
    Inventors: Li Ren, Yingjun Wang, Jian Zheng, Lin Wang, Sa Liu
  • Patent number: 10881781
    Abstract: A detoxification method includes the steps of inducing flow of patient blood through an extracorporeal device inlet and outlet in fluid connection to the circulatory system of a patient. Biological agents including lipopolysaccharide (LPS) contained within patient blood can be detoxified by passing patient blood over a biochemical reactor surface having attached or immobilized Saccharomyces boulardii alkaline phosphatase enzyme, with the biochemical reactor being contained within the extracorporeal device.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: January 5, 2021
    Assignee: ORTH CONSULTING, LLC
    Inventor: Donald S. Orth
  • Patent number: 10814045
    Abstract: The invention provides devices and methods for aneurysm treatment using a material that minimizes susceptibility artifacts in MRA images. Since images are not obscured by susceptibility artifacts associated with the aneurysm treatment device, those images are useful and reliable for evaluating the success of treatment. The material is preferably a non-ferromagnetic metal alloy and may include one or a combination of cobalt, nickel, chromium, and molybdenum. In certain embodiments, the material is a 35Cobalt-35Nickel-20Chromium-10Molybdenum-Low Titanium alloy medical-grade material.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: October 27, 2020
    Assignee: BALT USA
    Inventors: Randall Takahashi, David Ferrera
  • Patent number: 10765501
    Abstract: A soft breast prosthesis is provided, the prosthesis having a surface configuration advantageous for dual plane placement of the prosthesis in a breast.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: September 8, 2020
    Assignee: ALLERGAN, INC.
    Inventors: Dennis E. Van Epps, David J. Schuessler
  • Patent number: 10744759
    Abstract: A number of methods may be utilized to correct for the first drop dissimilarity in drop-on-demand inkjet devices. Various collection processes, mass calculations and timing manipulation may be utilized to correct the first drop dissimilarity problem.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: August 18, 2020
    Assignee: Cardinal Health Switzerland 515 GmbH
    Inventors: William J. Baldy, Jr., Amin Famili, Saurabh A. Palkar
  • Patent number: 10738418
    Abstract: Methods are described for treatment of aramid fibers to modify the surface of the fibers. The treated fibers have improved adhesion to elastomer materials as compared to untreated fibers. Modification methods include irradiating the fibers, compressing and straining the fibers under a constant pull force and immersing the fibers in a coupling agent fluid. The treated fibers can be used with elastomers and provide reinforcement elements in products such as tires.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: August 11, 2020
    Inventors: Nihal Kanbargi, Alan J. Lesser, Wei Zhao, Sheel P. Agarwal, Mindaugas Rackaitis
  • Patent number: 10731046
    Abstract: The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: August 4, 2020
    Assignee: Tufts University
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Hu Tao, Benedetto Marelli, Miaomiao Yang
  • Patent number: 10717838
    Abstract: A coated rubber composition includes a rubber composition coated with a liquid refresh agent selected from the group consisting of one or more liquid terpenes, limonene, carvone, pinene, pine needle oil, citral, orange oil, C9-C15 aliphatics, C9-C15 cycloaliphatics, ethyl lactate, dipentene, 1,8-cineole, eucalyptol, citronellol, geraniol, citronellene, terpinen-4-ol, and combinations thereof. A method of application and a coated rubber composition are also disclosed.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 21, 2020
    Assignee: Bridgestone Americas Tire Operations, LLC
    Inventors: Amy M. Randall, Maryangel G. Dunlavy
  • Patent number: 10709590
    Abstract: A manufacturing method of a stent is disclosed which prevents a drug from being peeled off or separated due to stress concentration or distortion resulting from the expanding deformation of the stent so that the drug is further uniformly effective and further improved yields are expected when the stent is manufactured, and a coating device. The method has a non-coating portion forming process of preventing a bending portion from being coated with the drug by causing a nozzle to go past the bending portion when the nozzle reaches the bending portion and to move toward main strut portions. In the non-coating portion forming process, an adhesion amount of a coating solution is reduced while the nozzle is going past the bending portion.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: July 14, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Kazuhiro Maruyama, Yasuyuki Kuroda, Masaki Watanabe, Kazuyuki Takeda
  • Patent number: 10695724
    Abstract: A porous membrane with a molecular weight cut-off (MWCO) greater than about 10 kDa, and a coating on at least a portion of a major surface of the porous membrane. The coating includes a star polymer having a hydrophobic core and hydrophilic arms, wherein the hydrophobic core contacts the porous membrane.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: June 30, 2020
    Assignee: International Business Machines Corporation
    Inventors: Geraud J. Dubois, Robert D. Miller, Young-Hye Na, Victoria Piunova, Joseph Sly, Andy T. Tek, Ran Wang
  • Patent number: 10688298
    Abstract: An implantable electrode system of is disclosed that includes a conductive electrode layer, an interconnect coupled to the electrode layer, an insulator that insulates the interconnect, and an anchor that more securely fixes the electrode layer in place. This structure is particularly useful with the electrode layer being a neural interface that is configured to provide either a recording or stimulating function. A method for forming such an implantable electrode system includes forming an interconnect over a base layer, forming an anchoring structure over the base layer, depositing an insulating material layer over the interconnect structure and over the anchoring structure, exposing a portion of the interconnect structure, forming an electrode layer over the insulating layer, the electrode layer contacting the exposed portion of the interconnect structure.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: June 23, 2020
    Assignee: NEURONEXUS TECHNOLOGIES, INC.
    Inventors: David S. Pellinen, Mayurachat Ning Gulari, Jamille Farraye Hetke, David J. Anderson, Daryl R. Kipke, Rio J. Vetter
  • Patent number: 10675144
    Abstract: A soft prosthetic implant shell, such as a silicone breast implant shell, that has discrete fixation surfaces thereon for tissue adhesion. The fixation surfaces may be provided on the posterior face of the shell, as well as either on the periphery or at discrete areas on the anterior face. Band-shaped fixation surfaces may be provided on the anterior face of the shell to generally match the angle of pectoralis major or pectoralis minor muscle groups. The fixation surfaces may be roughened areas of the shell, or may be separate elements adhered to the shell.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: June 9, 2020
    Assignee: ALLERGAN, INC.
    Inventors: Dennis Van Epps, Thomas E. Powell
  • Patent number: 10646619
    Abstract: A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and at least one closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a non-homogeneous external surface comprising individual clusters of flat crystal platelets consisting of epitactically grown HAP nanocrystals and coarse areas between the individual clusters, whereby the percentage of the coarse areas between the individual clusters as measured by SEM is at least 20% of the total surface, which material shows an increased capacity to induce bone formation, and a process of preparation thereof.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: May 12, 2020
    Assignee: GEISTLICH PHARMA AG
    Inventors: Claudio Zihlmann, Michael Bufler
  • Patent number: 10624990
    Abstract: The present application relates to bioactive implants, methods of making bioactive implants, and methods of using bioactive implants to treat or repair a bone defect or a cartilage defect. In an aspect, the present application relates to compositions comprising bone microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, the present application relates to compositions comprising cartilage microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, disclosed herein are methods of making and using the disclosed compositions comprising bone microparticles and the disclosed composition comprising cartilage microparticles. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: April 21, 2020
    Assignee: Osteolife Biomedical, LLC
    Inventor: Theodore Malinin
  • Patent number: 10617854
    Abstract: Methods and devices for trans-jugular carotid access are disclosed. Methods within the scope of this disclosure include methods of trans-jugular carotid access originating in the leg of a patient or other location remote to the jugular vein and carotid artery and methods originating at the neck of a patient. Devices used in connection with the disclosed methods may comprise access catheters, lumens, and stylets.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: April 14, 2020
    Assignee: Vascular Access Technologies, Inc.
    Inventor: Lakshmikumar Pillai
  • Patent number: 10526691
    Abstract: Provided is a nitrided metal surface functionalized with molecules, each molecule comprising at least one binding group and an antimicrobial moiety. The molecules are immobilized on the surface by only covalent interactions between the binding groups of the molecules and nitrogen atoms within the nitrided metal surface. Articles comprising the functionalized nitrided surface find use in inhibiting or reducing the growth of microorganisms on surfaces that are frequently touched. A method for preparing the functionalized nitrided surface comprises contacting a nitrided metal surface with molecules so as to form covalent bonds between the binding groups of the molecules and the nitrogen atoms in the surface, thereby immobilising the molecules on the metal surface.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: January 7, 2020
    Assignee: The University of Birmingham
    Inventor: Felicity Jane de Cogan
  • Patent number: 10519594
    Abstract: Supercritical fluid (“SCF”) is used to scour a target material to leave scour elements, such as oligomers and oils from the target material. Carbon dioxide (“CO2”) is introduced into a pressure vessel also containing the target material to be scoured. The CO2 is raised in temperature and pressure to a SCF state. The CO2 is recirculated within the pressure vessel to scour the target material. An exchange of the CO2 is occurs allowing for the scoured elements to be removed from the CO2 and therefore from within the pressure vessel. Operation variables such as temperature, pressure, time, internal flow rate, and CO2 exchange are adjusted to achieve a scouring of the target material.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: December 31, 2019
    Assignee: NIKE, Inc.
    Inventors: Matt W. Kelly, Gerardo A. Montero, Anand P. Kanchagar, Pankaj Rugnath Panchmatia
  • Patent number: 10485109
    Abstract: Flexible electrical devices comprising electrode layers on softening polymers and methods of manufacturing such devices, including lift-off processes for forming electrodes on softening polymers, processes for forming devices with a patterned double softening polymer layer, and solder reflow processes for forming electrical contacts on softening polymers.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: November 19, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Romil Modi, Jonathan Reeder, Gregory T. Ellson, Walter Voit, Alexandra Joshi Imre
  • Patent number: 10463512
    Abstract: Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: November 5, 2019
    Assignee: Medtronic Vascular, Inc.
    Inventors: Justin Peterson, James Mitchell, Abby S Pandya, Nate Glucklich, Joseph Berglund, Ya Guo
  • Patent number: 10448970
    Abstract: The present disclosure relates to the field of endovascular treatment. More particularly, the present invention uses a modified hydrogel intrasaccular occlusion device designed to implement an endovascular treatment to ameliorating or eliminating aneurysm recurrence, which hydrogel may optionally be impregnated with pharmaceutical compounds. The present invention also teaches the use of thin hydrogel coatings to ameliorate endovascular treatment related difficulties.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: October 22, 2019
    Inventor: Daniel E. Walzman
  • Patent number: 10434216
    Abstract: The present invention relates to an ultra-thin film silk fibroin/collagen composite implant for tissue engineering and a manufacturing method therefor. The ultra-thin film silk fibroin/collagen silk fibroin/collagen composite implant according to the present invention has no cytotoxicity and can minimize the influence on cell growth, due to the combined use of a refined silk fibroin aqueous solution, collagen and various biomaterials, and thus can be widely used as an ultra-thin film implant for implanting.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: October 8, 2019
    Assignee: Industrial Cooperation Foundation Chonbuk National University
    Inventors: Gil Son Khang, Eun Young Kim, Jae Won Yang, Jeong Eun Song, Se Rom Cha
  • Patent number: 10426547
    Abstract: An optical device including an optical fiber having a longitudinal axis and an optical fiber core with a distal end having a distal terminating end configured to discharge a first laser energy in a first direction and a second laser energy in a second direction. The optical device also includes a fiber cap having an interior cavity and an opening to the interior cavity, where the distal end of the optical fiber core is received within the interior cavity through the opening. A cladding is included on the distal end of the optical fiber core between the optical fiber core and the fiber cap.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: October 1, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Thomas Charles Hasenberg, Rongwei Jason Xuan, Brian P. Watschke, Douglas Lawrence Evans, Guangjian Wang, Steven Yihlih Peng, Wen-Jui Ray Chia
  • Patent number: 10428200
    Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: October 1, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA, Northwestern University
    Inventors: Ton That Hai, John-Bruce Devault Green, Timothy Michael Fulghum, Phillip Byron Messersmith, Tadas Stanislovas Sileika
  • Patent number: 10413638
    Abstract: Provided are surface-modified rubbers or surface-modified thermoplastic elastomers, such as catheters, syringe barrels, tubes of medical instruments, and mudguard fenders, and methods for modifying the surface of rubber or a thermoplastic elastomer, wherein a lubricant layer is firmly bonded to the surface of medical devices such as catheters, syringe barrels, and tubes of medical instruments to impart lubricity to the surface and, further, improve the durability of the lubricant layer on the surface, thereby suppressing deterioration of the sliding properties. Included is a surface-modified rubber or a surface-modified thermoplastic elastomer each having a surface at least partially treated by polymerization of a monomer in the presence of a thermal polymerization initiator.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: September 17, 2019
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventor: Yasuhisa Minagawa
  • Patent number: 10408821
    Abstract: Disclosed herein are devices that include a top chamber including at least one port, a bottom chamber including at least one inlet and at least one outlet, wherein the opening of the at least one inlet is smaller than the opening of the at least one outlet, and a membrane located between the top chamber and the bottom chamber, wherein the membrane is fluidly coupled with the top chamber and the bottom chamber. Also disclosed herein are systems including the disclosed devices. The systems include liquid in one or more of the chambers of the device. Methods of using the devices and systems include producing a vacuum by flowing a liquid through the bottom chamber of the system. Due to the difference in size of the inlet and outlet in the bottom chamber, a vacuum is produced in the top chamber.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: September 10, 2019
    Assignee: Triad National Security, LLC
    Inventors: Pulak Nath, Jen-Huang Huang
  • Patent number: 10279372
    Abstract: A method for forming a coating on a stent involves spraying or drying a coating on the stent while the stent is supported on a mandrel assembly, during which part of the stent is made to go out of contact with the mandrel assembly.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: May 7, 2019
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Yung-Ming Chen, Jason Van Sciver, Jeff McCabe, Antonio Garcia
  • Patent number: 10214608
    Abstract: Methods are provided for surface-modifying a rubber vulcanizate or a thermoplastic resin. The methods allow these objects to have a chemically fixed surface layer that exhibits not only low adsorption or selective adsorption properties with respect to proteins and cells, but also excellent durability, instead of having a coating which has drawbacks such as reduction in properties due to separation or peeling of the coating. Included is a method for surface-modifying an object made of a rubber vulcanizate or a thermoplastic resin, the method including: a step 1 of forming polymerization initiation points on the surface of the object; and a step 2 of radically polymerizing a hydrophilic monomer starting from the polymerization initiation points by irradiation with UV light having a wavelength of 300 to 400 nm in the presence of an alkali metal salt to grow polymer chains on the surface of the object.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: February 26, 2019
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventor: Yasuhisa Minagawa
  • Patent number: 10201637
    Abstract: Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: February 12, 2019
    Assignee: Surmodics, Inc.
    Inventors: David E. Babcock, Sean Lundquist, Gary Opperman, Adriyn Torguson, Tim Jentz
  • Patent number: 10174276
    Abstract: Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink, and support material; a UV light module for optionally exposing the contents of at least one cartridge to UV light; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Also described herein are methods of using and bioprinting cartridges for such bioprinters.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: January 8, 2019
    Assignee: Organovo, Inc.
    Inventors: Keith Murphy, Scott Dorfman, Richard Jin Law, Vivian Anne Le
  • Patent number: 10145629
    Abstract: The present disclosure is directed to a metal-containing apparatus including a substrate member constructed of a metal that is highly resistant to pitting corrosion and wear in aggressive media. An exemplary metal-containing apparatus is a plate heat exchanger. The metal includes an oxidation layer on the surface thereof and a thin metal oxide nanoporous film on top of the oxidation layer. The nanoporous film is highly compliant and is comprised of oxygen and aluminum, titanium, silicon, zirconium and combinations thereof.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: December 4, 2018
    Assignee: Wisconson Alumni Research Foundation
    Inventors: Marc A. Anderson, M. Isabel Tejedor, Ole Christensen
  • Patent number: 10058889
    Abstract: A method of forming a biocompatible or biologically inert article for use in an application in which the article will make contact with at least one tissue, organ, or fluid within a human or animal body is provided. The method generally comprises providing an article having an external surface; selecting chemical precursors; using a means to direct one or more chemical precursors towards or to apply such chemical precursors to the external surface; activating the chemical precursors by exposing said precursors to atmospheric pressure plasma; and grafting and/or cross-linking the chemical precursors to form a solid coating adjacent to the external surface of the article.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: August 28, 2018
    Assignee: Kettering University
    Inventors: Mary Gilliam, Susan Farhat, Ali Zand
  • Patent number: 10039865
    Abstract: The invention relates to a prosthetic for repairing an opening or a defect in a soft tissue, to its preparation and use. The prosthetic of the invention comprises a substrate viscerally-coated with stabilized and non-completely dry fibrin. The prosthetic displays reduced postoperative complications following its implantation.
    Type: Grant
    Filed: September 21, 2009
    Date of Patent: August 7, 2018
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Eyal Sheetrit, Israel Nur, Liliana Bar, Lior Weissman
  • Patent number: 9999595
    Abstract: The invention provides a sustained release intraocular drug delivery device comprising: (a) a polymeric matrix core into which at least one therapeutic agent is mixed, and; (b) a polymeric coating completely surrounding said polymeric matrix material; wherein said polymeric matrix core and polymeric coating are insoluble and inert in ocular fluids, and wherein said sustained release intraocular drug delivery device has a compliant annular segment shape and is to be inserted into the sulcus of the intact and/or pseudophakic eye.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: June 19, 2018
    Assignee: EYED PHARMA
    Inventors: Jean-Marie Rakic, Jean-Michel Foidart
  • Patent number: 9949480
    Abstract: The present invention provides N-alkylthio ?-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and methods of their use as anti-bacterial agents.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: April 24, 2018
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Edward Turos, Kevin D. Revell
  • Patent number: 9895468
    Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: February 20, 2018
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA, NORTHWESTERN UNIVERSITY
    Inventors: Ton That Hai, John-Bruce Devault Green, Timothy Michael Fulghum, Phillip Byron Messersmith, Tadas Stanislovas Sileika
  • Patent number: 9821091
    Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: November 21, 2017
    Assignee: Abbot Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, Fuh-Wei Tang, Lothar W. Kleiner, Thierry Glauser, Yiwen Tang, Wouter E. Roorda, Stephen D. Pacetti, Gina Zhang, Yung-Ming Chen, Andrew F. McNiven, Sean A. McNiven, Brandon J. Yoe
  • Patent number: 9809717
    Abstract: The disclosure provides polymers having antimicrobial activity and articles with the polymers coated thereon. The polymers include a first pendant group comprising a first cationic component, a second pendant group comprising a nonpolar component, and a third pendant group comprising an organosilane component. The disclosure also includes methods of coating medical device articles and body fluid-receiving substrates with the antimicrobial polymers. The methods further include the use of adhesion-promoting components.
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: November 7, 2017
    Assignee: 3M Innovative Properties Company
    Inventors: Mahfuza B. Ali, Naiyong Jing, Valeri Lirine, Pradnya V. Nagarkar, Caroline M. Ylitalo, Nancy S. Lennhoff, Matthew T. Scholz, Ranjani V. Parthasarathy
  • Patent number: 9802216
    Abstract: An automated apparatus and method for coating medical devices such as an intravascular stent, are disclosed in the method, a 2-D image of a stent is processed to determine (1) paths along the stent skeletal elements by which a stent secured to a rotating support element can be traversed by a dispenser head whose relative motion with respect to the support element is along the support-element axis, such that some or all of the stent skeletal elements will be traversed (2) the relative speeds of the dispenser head and support element as the dispenser head travels along the paths, and (3), and positions of the dispenser head with respect to a centerline of the stent elements as the dispenser head travels along such paths The rotational speed of the support and relative linear speed of the dispenser are controlled to achieve the desired coating thickness and coating coverage on the upper surfaces, and optionally, the side surfaces, of the stent elements.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: October 31, 2017
    Assignee: Biosensors International Group, Ltd.
    Inventors: Ivan Vecerina, Vinh Pham
  • Patent number: 9770576
    Abstract: Methods and apparatus for coating a medical device are provided. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: September 26, 2017
    Assignee: Lutonix, Inc.
    Inventors: Jeffrey Wang, Harrison Malinoff, Lixiao Wang, Christopher M. Barry, Dennis W. Wahr, Scott R. Naisbitt
  • Patent number: 9750839
    Abstract: Medical devices possessing coatings are provided. The coatings include at least one polyelectrolyte, capable of changing the surface charge of the device to which they are applied. The polyelectrolytes permit attachment of charged bioactive agents thereto. Multiple polyelectrolytes, possessing opposite charges, may be sequentially applied to produce a medical device having multiple layers. Methods for forming such devices are also provided.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: September 5, 2017
    Assignee: Covidien LP
    Inventor: Arpan Desai
  • Patent number: 9750853
    Abstract: This invention relates to stents, a type of implantable medical device, with an antiproliferative coating and a prohealing luminal coating and methods of fabricating stents with an antiproliferative coating and a prohealing luminal coating.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: September 5, 2017
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Bin Huang, David C. Gale, Daniel A. Castro, Vincent J. Gueriguian
  • Patent number: 9744259
    Abstract: Stent scaffolds comprising branched biocompatible polymers are disclosed.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: August 29, 2017
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Yunbing Wang, David C. Gale, Bin Huang, Mikael O. Trollsas, Thierry Glauser, Florian Ludwig