For Mineralized Body Part (e.g., Bone, Tooth, Crown, Hip) Patents (Class 427/2.26)
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Publication number: 20090048627Abstract: The present disclosure provides a method for forming a color pattern on a medical device.Type: ApplicationFiled: February 22, 2007Publication date: February 19, 2009Inventor: Ahmad R. Hadba
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Publication number: 20090022811Abstract: The present invention provides a method for mineralizing commercially available guided bone regeneration membranes. The method comprises the steps of (a) providing a commercially available guided bone regeneration membrane, (b) applying a mineralizing solution, and (c) microwaving the membrane. The method may further comprise (d) rinsing the membrane in a solution such as distilled water and (e) drying the membrane. The mineralizing solution may be a solution capable of supplying or delivering a mineral such as calcium or zinc. The invention further provides guided bone regeneration membranes made by the methods described. The guided bone regeneration membrane comprises a mineral, such as, for instance calcium or zinc at a weight percent of at least 5%, at least 10%, at least 12%, at least 15%, at least 18%, at least 20% or at least 25% (weight percent) of the membrane. Further, the invention provides methods for enhancing bone regeneration and methods for inhibiting bacterial infection and inflammation.Type: ApplicationFiled: March 7, 2008Publication date: January 22, 2009Inventors: Racquel Z. LeGeros, Hung-Kuo Chou, Dindo Mijares, John P. LeGeros
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Publication number: 20090022878Abstract: A method to impregnate a porous bone replacement material (1) with a liquid impregnating agent (5), wherein a) the bone replacement material (1) is or will be enclosed in a chamber (2) with two openings (3, 4) that can be closed, b) the impregnating agent (5) is introduced into the chamber (2) until the bone replacement material (1) is at least partly immersed in the impregnating agent (5), c) one of the two openings (3, 4) will be closed, d) the chamber (2) is evacuated at least partly via the other, open, opening (4, 3), so that the air contained in the pores of the bone replacement material (1) is at least partly removed from it, e) the vacuum produced in the chamber is terminated again by supplying air or a gas through one of the openings (3, 4), and f) the vacuum produced in the pores of the bone replacement material (1) is terminated by the impregnating agent (5) penetrating into the pores of the bone replacement material (1) immersed into the impregnating agent (5).Type: ApplicationFiled: September 30, 2008Publication date: January 22, 2009Inventors: Flavio Hoerger, Thierry Stoll
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Publication number: 20090017087Abstract: This invention provides an Osseo-inductive metal implant for a living body and the producing method thereof and, more particularly, the Osseo-inductive metal implant for a living body according to the present invention is produced by forming, on the surface of the metal implant, the layer of metal oxide and the layer of bio-active material injected.Type: ApplicationFiled: March 31, 2005Publication date: January 15, 2009Applicant: KOREA INSTITUTE OF MACHINERY AND MATERIALSInventors: Eung-Sun Byon, Yong-Soo Jeong, Jong-Kuk Kim, Young-Taeg Sul, Beom-Seok Chang, Lee-Ra Cho
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Publication number: 20090012523Abstract: The invention relates in general level to a method for coating articulating surfaces of medical products. The invention also relates to coated medical products manufactured by the method. The coating is carried out by employing ultra short pulsed laser deposition wherein pulsed laser beam is preferably scanned with a rotating optical scanner including at least one mirror for reflecting the laser beam. The invention has several both industrially and qualitatively advantageous effects such as high coating production rate, excellent coating properties and overall low manufacturing costs.Type: ApplicationFiled: February 23, 2007Publication date: January 8, 2009Applicant: PICODEON LTD OYInventors: Jari Ruuttu, Reijo Lappalainen, Vesa Myllymaki, Lasse Pulli, Juha Makitalo
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Publication number: 20080292779Abstract: A method for fabricating and/or coating an implant or other structure to be inserted into bone or osseous tissue, including dental implants, is described in which the surface of the implant is treated with a hyaluronic acid solution to form a thin film conformal coating of the hyaluronic solution over the surface of the implant. The surface of the implant may be roughened and cleaned prior to treating the surface with the hyaluronic solution. After the coating is formed, the implant may be sterilized.Type: ApplicationFiled: April 28, 2008Publication date: November 27, 2008Inventors: Gregory M. Mercuri, James G. Hall
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Patent number: 7452566Abstract: A magnesium titanate oxide film implant, and a method for preparing the same. The magnesium titanate oxide film implant is prepared by forming a titanium oxide film (a magnesium titanate oxide film) in which magnesium is incorporated into the surface of titanium or a titanium alloy. A magnesium titanate oxide film implant is prepared by irradiating UV light on an implant body made of titanium or a titanium alloy in distilled water, dipping the UV light-irradiated implant body in an electrolyte solution containing magnesium, and coating a magnesium titanate oxide film on the dipped implant body by anodic oxidation. Therefore, the present invention can provide an implant having increased bioactivity of a titanium oxide film formed by anodic oxidation, and provides an optimum magnesium titanate oxide (TixMgyOz) thickness for successful osseointegration of the magnesium titanate (TixMgyOz) implant.Type: GrantFiled: March 4, 2004Date of Patent: November 18, 2008Inventor: Young-Taek Sul
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Publication number: 20080262631Abstract: This invention relates to a method for crystallizing an amorphous calcium phosphate (Cap) by high energy laser light irradiation. The method is particularly suited for crystallizing CaP coatings on polymeric substrates, particularly implant objects.Type: ApplicationFiled: January 19, 2005Publication date: October 23, 2008Applicant: STITCHING KATHOLIEKE UNIVERSITEITInventors: Johannes Arnoldus Jansen, Bastiaan Feddes, Johannes Gerardus Cornelis Wolke, Arjen Maarten Vredenberg
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Publication number: 20080260836Abstract: Films are disclosed that comprise a first polymer and a second polymer having a solubility temperature lower than that of the first polymer; wherein the breaking strength of the film is greater than about 750 psi (5,171 kPa). Also disclosed are compositions comprising such films that are useful as oral care, personal care or home care compositions. Methods of using such compositions are also disclosed.Type: ApplicationFiled: April 18, 2007Publication date: October 23, 2008Inventor: Thomas James Boyd
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Publication number: 20080241353Abstract: The invention relates to a biomimetic process for coating a substrate, particularly a medical device, with a biomimetic composition, which comprises: d) producing batchwise in a closed system an acidified biomimetic composition comprising a saline aqueous mixture containing calcium-, magnesium-, phosphate-, bicarbonate ions and a bioactive substance, e) contacting the substrate with said biomimetic composition and f) storing the biomimetic composition in contact with the substrate and allowing a gradual increase of the pH to occur and to cause precipitation of salts and co-precipitation of the bioactive substance on said substrate and to obtain a coated substrate.Type: ApplicationFiled: August 10, 2005Publication date: October 2, 2008Inventor: Yuelian Liu
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Patent number: 7425345Abstract: An apparatus comprises a dispenser, a coherent energy source and an beam steering system. The dispenser defines a path of a droplet. The beam steering system is coupled to the coherent energy source and is configured to define a beam path of the coherent energy source. The beam path of the coherent energy source is disposable across the dispenser path at an interaction location. The beam steering system and coherent energy source are collectively configured such that at least one of a direction, a velocity and an acceleration of the droplet is modified within the interaction location.Type: GrantFiled: March 2, 2004Date of Patent: September 16, 2008Assignee: Boston Scientific Scimed, Inc.Inventor: Jan Weber
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Publication number: 20080206443Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: ApplicationFiled: May 5, 2008Publication date: August 28, 2008Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen S. Gawalt
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Patent number: 7407684Abstract: A multi-step method of manufacturing a medical device containing therapeutic agents that results in a lower maximum error in the amount of therapeutic agents actually disposed thereon and that allows for differential drug release kinetics along the length of the medical device.Type: GrantFiled: January 28, 2004Date of Patent: August 5, 2008Assignee: Boston Scientific Scimed, Inc.Inventors: Steven M. Spencer, Jan Weber
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Publication number: 20080160169Abstract: A method for coating a medical device with a bioactive peptide comprising: providing a medical device to be coated with a bioactive peptide to a cylinder; attaching a syringe containing a bioactive peptide coating solution; introducing into the cylinder the bioactive peptide coating solution when the first valve of the connector and the second valve of the connector are open; incubating the medical device within the cylinder with the bioactive peptide coating solution; removing the bioactive peptide coating solution from the cylinder after the medical device is coated with the bioactive peptide.Type: ApplicationFiled: December 21, 2007Publication date: July 3, 2008Inventors: Paul O. Zamora, Brent Lee Atkinson
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Patent number: 7390525Abstract: A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) subsequently applying a polymer-containing layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross-linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Moreover, in certain embodiments, the polymer-containing layer does not comprise the cross-linking agent at the time the polymer-containing layer is applied over the reactive layer. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.Type: GrantFiled: January 12, 2005Date of Patent: June 24, 2008Assignee: Boston Scientific Scimed, Inc.Inventors: Samuel J. Epstein, Wendy Naimark
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Patent number: 7390526Abstract: Biocompatible composites comprising peptide amphiphiles and surface modified substrates and related methods for attachment thereon.Type: GrantFiled: February 11, 2004Date of Patent: June 24, 2008Assignee: Northwestern UniversityInventors: Samuel I. Stupp, Erik D. Spoerke, Shawn G. Anthony, Krista L. Niece
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Patent number: 7371424Abstract: Methods and apparatuses for coating surface of medical devices using coating heads are disclosed. In one embodiment, the invention includes a coating method using a coating head, wherein the coating head comprises at least one outlet orifice from which flows a coating material, to deposit at least one layer of coating material dispelled through the outlet orifice onto the surface of the medical device. In another embodiment, a slide coating head is used to deposit multiple layers of superposed coating materials. These methods are used to apply one or more coating materials, simultaneously or in sequence. In certain embodiments of the invention, the coating materials include therapeutic agents, polymers, sugars, waxes, or fats.Type: GrantFiled: April 14, 2004Date of Patent: May 13, 2008Assignee: Boston Scientific Scimed, Inc.Inventor: Marlene C. Schwarz
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Patent number: 7368065Abstract: Compositions and methods are provided for preparing a metal substrate having a uniform textured surface with a plurality of indentations with a diameter in the nanometer and micrometer range. The textured surface is produced by exposing the substrate to an etching fluid comprising a hydrohalic acid and a mixture of a hydrohalic acid and an oxyacid, a chloride containing compound, and an oxidant. The etching solution can be used at ambient temperature. This textured surface enhances adherence of coatings or cells onto the textured surface, improves the retention of proteins on the surface, and encourages bone in-growth.Type: GrantFiled: June 23, 2005Date of Patent: May 6, 2008Assignee: DePuy Products, Inc.Inventors: Xiaofan Yang, Panjian Li, Todd Smith
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Publication number: 20080097618Abstract: The invention is a medical implantable device which is coated by the method according to the invention. The surface of the substrate used for the implantable device, in the raw condition, following a cleaning regime and physiochemical pretreatments, is coated using a biomimetic process in a supersaturated calcium phosphate solution (SCPS) to obtain the desired coating coverage and morphology maintaining a ratio of calcium to phosphorus pH, as well as solution temperature plays a major role in yielding precipitation of the proper phase of CaP so that composition, morphologies, crystal structures, and solubility characteristics are optimal for the deposition process. The biomimetic coating adds the attribute of osteoconductivity to the implant device. To maximize bone growth, the implant must also induce bone growth, or possess the attribute of osteoinductivity. This attribute is acquired by the use of therapeutic agents, i.e. bone morphogenic proteins (BMP), growth factors, stem cells, etc.Type: ApplicationFiled: April 2, 2007Publication date: April 24, 2008Inventors: Kevin Charles Baker, Jaroslaw Wieslaw Drelich
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Patent number: 7344749Abstract: A method for coating substrates with calcium phosphate. The aim of the method is to be able to carry out a simple coating for all materials as well as for particles. To this end, the substrate to be coated is placed in a calcium phosphate gel, whereupon this substrate that is coated with the gel is dried. Afterwards, the calcium phosphate particles not adhering to the substrate are removed. The substrate can also be placed inside a colloidal solution of SiO2 containing a calcium phosphate, whereupon the mixture is constantly set in motion, the solvent is removed, and the substrate is provided with a calcium phosphate layer by condensing the colloidal SiO2 on the surface of the substrate. The coated substrates can, particularly when it concerns coated particles, be used as a bone substitute material.Type: GrantFiled: December 6, 2002Date of Patent: March 18, 2008Assignee: DOT GmbHInventors: Petra Becker, Mischa Buhrmeister, Hans-Georg Neumann, Marianne Teller
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Patent number: 7323211Abstract: It is to provide an implant with shock-absorbing property that is able to be strongly secured in a living body as well as a manufacturing method of such implant. The implant comprising: a substrate; a first film on the substrate, which is comprised of a polymer and has a functional group that enables adsorption of calcium ions; and a second film formed on the first film and being comprised of calcium phosphate. The manufacturing method of the implant comprising: forming said first film on a substrate; and subsequently, dipping the substrate in a calcium ion solution and in a phosphate ion solution alternately as to form the second film.Type: GrantFiled: May 13, 2004Date of Patent: January 29, 2008Assignee: BMG IncorporatedInventors: Suong-Hyu Hyon, Kazuaki Matsumura, Sadami Tsutsumi
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Patent number: 7323208Abstract: Modified porous materials are disclosed having interconnected, complexly shaped three-dimensional surfaces. The modification is accomplished by crosslinking the three-dimensional surfaces and/or by coating the three-dimensional surfaces with a layer of a predetermined material. The porous materials are macro structures including at least one of nano-features, micro-features, and combinations thereof. The modifying accomplishes changing surface properties of the porous materials, changing the three-dimensional surfaces, and/or rendering the porous materials substantially stable in a predetermined environment.Type: GrantFiled: November 30, 2004Date of Patent: January 29, 2008Assignee: The Regents of the University of MichiganInventors: Peter X. Ma, Xiaohua Liu
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Patent number: 7258810Abstract: A textured surface and oxidation layer coating on a metallic material is accomplished through the chemical and/or electrochemical etching of the surface to modify the surface texture and an in-situ oxidation procedure. The surface is useful for the fabrication of prosthetic devices, particularly medical implants, due to the corrosion and wear resistance imparted by the oxidation layer and the ability to enhance grafting of the implant onto bone imparted by the surface texture.Type: GrantFiled: December 6, 2002Date of Patent: August 21, 2007Assignee: Smith & Nephew, Inc.Inventors: Gordon Hunter, Randy Fesmire, Harsh Gupta, Daniel Heuer
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Patent number: 7252685Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises at least one structural member combined with at least one flexible planar member to retain the at least one structural member to form the implant.Type: GrantFiled: June 5, 2003Date of Patent: August 7, 2007Assignee: SDGI Holdings, Inc.Inventors: James J. Bindseil, William F. McKay, Cary R. Reeves, T. Andrew Simonton, Eddie F. Ray
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Patent number: 7156851Abstract: An implant and a process of modifying an implant surface, which implant is in particular a hip implant, a tooth implant, a bone screw, fixation pin or a fixation nail (pin-fixation), comprising a metallic base body, which implant has a surface modified by a material containing a tissue-friendly metal, such as tantalum or niobium, for the formation of a surface modification where at least the tissue-friendly metal is alloyed with the surface and constitutes a uniform, diffusion-tight outer zone on the body, which outer zone has a higher ductility than the metallic base body in order to obtain a tissue-friendly implant with increased fatigue strength.Type: GrantFiled: February 12, 2002Date of Patent: January 2, 2007Assignee: Danfoss A/SInventor: John Christensen
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Patent number: 7144428Abstract: A section of the implant is treated successively and separately with three different acids—hydrofluoric, sulphuric and hydrochloric acid— to create evenly distributed peaks on the surface and sufficient surface area. Plasma rich in growth factors is then applied to said surface.Type: GrantFiled: September 14, 2001Date of Patent: December 5, 2006Inventor: Eduardo Aldecoa Anitua
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Patent number: 7087085Abstract: An osteogenic implant with improved osteointegration properties, this implant being made of titanium metal or a titanium-based alloy and being suitable for implantation in bones, said implant having a roughened surface, which in the hydroxylated state has been at least partially covered with a compound which comprises in the molecule at least two groups which are, independently of one another, a primary amino group, a secondary amino group, a carboxyl group, an amide group, a phosphano group and/or hydroxyl, or with a mixture of such compounds.Type: GrantFiled: July 24, 2001Date of Patent: August 8, 2006Assignee: Straumann Holding AGInventors: Samuel G. Steinemann, James Parcival Simpson
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Patent number: 7052514Abstract: The present invention makes available an optimal concentration of a hedgehog polypeptide for modulating growth and/or cartilage production by chondrocytes. The present invention allows for improvements in the culturing of chondrocytes to develop cartilaginous tissue ex vivo suitable for implantation to replace damaged or deteriorated cartilage in a patient.Type: GrantFiled: April 27, 2001Date of Patent: May 30, 2006Assignee: Curis, Inc.Inventors: Karin Kellner, Kurt Lang, Apollon Papadimitriou, Ulrike Leser-Reiff, Michaela Schultz, Torsten Blunk, Achim Goepferich
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Patent number: 6994883Abstract: The invention relates to the field of medical devices. More in particular, the invention relates to a method for coating by depositing inorganic ions and a bioactive agent to provide sterile medical devices, wherein said coating improves the biocompatibility and/or bioactivity of a medical device, such as an orthopedic or dental prosthesis. Furthermore, the invention relates to a medical device coated with a method according to the invention and to a reactor for use in a method according to the invention.Type: GrantFiled: July 30, 2003Date of Patent: February 7, 2006Assignee: IsoTis S.A.Inventors: Pierre Jean F. Layrolle, Martin Stigter, Klaas De Groot, Yuelian Liu
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Patent number: 6994550Abstract: A coating for a biomedical device is disclosed, including a metal layer and/or a ceramic layer, such as a layer of titanium (Ti) and a layer of titanium-nitride (TiN). The coating can form a coping for a crown for a tooth, the crown including a porcelain layer bonded to the titanium-nitride (TiN) layer. Methods for making and using a biomedical device are also disclosed, including vapor deposition of metal and/or ceramic layers, such as titanium (Ti) and titanium-nitride (TiN) layers. In one embodiment, the method includes forming a titanium (Ti) vapor that solidifies to form a titanium (Ti) layer; forming a titanium-nitride (TiN) vapor that coats the titanium (Ti) layer with a titanium-nitride (TiN) layer; and forming a porcelain layer on the titanium-nitride (TiN) layer. The porcelain can be sintered to form a dental crown or other device.Type: GrantFiled: July 17, 2003Date of Patent: February 7, 2006Assignee: Nano-Write CorporationInventors: Kenneth E. Knapp, Michael L. Hedrick
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Patent number: 6984236Abstract: The above-discussed and other problems and deficiencies of the prior art are overcome or alleviated by the improved bone connective prosthesis and method of forming the same of the present invention, comprising the addition of at least one biocompatible metal coupling agent to a prosthetic element, and then adding the biocompatible copolymerizer 2-hydroxyethyl methacrylate (“HEMA”) to the PMMA film and/or cement in an amount effective to enhance the cohesion between the prosthetic and the bone cement. In general, a PMMA/HEMA film is applied to the prosthetic element in the presence of a silane coupling agent by dipping, painting, spraying, etc.Type: GrantFiled: October 24, 2002Date of Patent: January 10, 2006Assignee: Faro Technologies, Inc.Inventor: Simon Raab
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Patent number: 6977095Abstract: A process for producing a rigid reticulated article involves coating a reticulated substrate which has open, interconnected porosity with a first dispersion comprising a ceramic or metal powder to form a first coating thereon; drying the coated reticulated substrate; contacting the coated reticulated substrate with one or more additional dispersions in succession to form one or more additional coatings thereon; drying the additional coatings between the steps of contacting; heating the coated reticulated substrate to pyrolyze organic components; and sintering the coated reticulated substrate to form a reticulated article, wherein each dispersion has a viscosity less than that of all preceding dispersions. A rigid reticulated article includes inner, intermediate and outer sintered layers of material in which the inner and outer layers are of different composition and the intermediate layer is a composite of the inner and outer layers.Type: GrantFiled: November 15, 1999Date of Patent: December 20, 2005Assignee: Wright Medical Technology Inc.Inventors: Jeffrey G. Marx, Bradley R. Heckendorf, James R. Johnson, John Jeffrey Venarsky
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Patent number: 6969474Abstract: The surface of a device that is surgically implantable in living bone is prepared. The device is made of titanium with a native oxide layer on the surface. The method of preparation comprises the steps of removing the native oxide layer from the surface of the device and performing further treatment of the surface substantially in the absence of unreacted oxygen.Type: GrantFiled: November 5, 2003Date of Patent: November 29, 2005Assignee: Implant Innovations, Inc.Inventor: Keith D. Beaty
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Patent number: 6923996Abstract: A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) subsequently applying a polymer-containing layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross-linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.Type: GrantFiled: May 6, 2003Date of Patent: August 2, 2005Assignee: SciMed Life Systems, Inc.Inventors: Samuel J. Epstein, Wendy Naimark
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Patent number: 6919100Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism or to treat a particular condition. A dip coating process is utilized to minimize waste. An aqueous latex polymeric emulsion is utilized to coat any medical device to a desired thickness by allowing for successive dipping and drying cycles. In addition, aqueous latex polymeric emulsions pose less of a chance of the bridging phenomenon associated with organic solvent based polymers.Type: GrantFiled: January 22, 2003Date of Patent: July 19, 2005Assignee: Cordis CorporationInventor: Pallassana V. Narayanan
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Patent number: 6899915Abstract: Tooth tissues include the pulp mesenchyme that forms the dentin and an epithelium that is responsible for enamel formation. Cells from these tissues were obtained from porcine third molars and were seeded onto a biodegradable scaffold composed of a polyglycolic acid—polylactic acid copolymer. Cell polymer constructs were then surgically implanted into the omentum of athymic nude rats so that the constructs would have a blood supply and these tissues were allowed to develop inside the rats. Infrequently, columnar epithelial cells were observed as a single layer on the outside of the dentin-like matrix similar to the actual arrangement of ameloblasts over dentin during early tooth development. Developing tooth tissues derived from such cell polymer constructs could eventually be surgically implanted into the gum of an edentulous recipient where the construct would receive a blood supply and develop to maturity, providing the recipient with a biological tooth replacement.Type: GrantFiled: November 29, 2001Date of Patent: May 31, 2005Assignees: President and Fellows of Harvard College, General Hospital Corporation, Forsyth Dental Infirmary for Children, Inc.Inventors: Pamela C. Yelick, John D. Bartlett, Joseph P. Vacanti, Bjorn R. Olsen, Phillip Stashenko
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Calcium phosphate bone graft material, process for making same and osteoimplant fabricated from same
Patent number: 6846853Abstract: A calcium phosphate bone graft material comprising an amorphous calcium phosphate glassy phase of from about 30 to about 100 volume % is obtained by plasma spraying calcium phosphate-containing powder onto a target to produce a deposited layer and removing the deposited layer from the target to provide the calcium phosphate bone graft material.Type: GrantFiled: July 16, 2002Date of Patent: January 25, 2005Assignee: Osteotech, Inc.Inventor: Lawrence A. Shimp -
Publication number: 20040265165Abstract: The invention provides a process for quenching free radicals present in irradiated ultrahigh molecular weight polyethylene comprising the steps of (a) providing a mass of irradiated ultrahigh molecular weight polyethylene, wherein the mass comprises free radicals, (b) immersing at least a portion of the mass of irradiated ultrahigh molecular weight polyethylene in a non-polar solvent having a temperature for a time and under conditions sufficient to quench a substantial portion of the free radicals contained therein, wherein the temperature of the non-polar solvent is maintained below the melting point of the ultrahigh molecular weight polyethylene, (c) removing the mass of irradiated ultrahigh molecular weight polyethylene from the non-polar solvent, and (d) removing any non-polar solvent from the mass of irradiated ultrahigh molecular weight polyethylene.Type: ApplicationFiled: June 30, 2003Publication date: December 30, 2004Applicant: DePuy Products, Inc.Inventor: Richard King
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Patent number: 6821528Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.Type: GrantFiled: July 1, 2003Date of Patent: November 23, 2004Assignee: Howmedica Osteonics Corp.Inventors: Christopher Scott, Joseph Zitelli, Paul Higham
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Patent number: 6803069Abstract: Disclosed are implantable medical devices with enhanced patency. Expanded polytetrafluoroethylene small caliber vascular grafts coated with polymer bound bio-active agents that exhibit enhanced patency are disclosed. The polymer bound bio-active agents can include anti-thrombogenic agents, antibiotics, antibacterial agents and antiviral agents. Methods of preparing same are also provided.Type: GrantFiled: June 20, 2001Date of Patent: October 12, 2004Assignee: SciMed Life Systems, Inc.Inventors: Birendra K. Patnaik, Horng-Ban Lin, David J. Lentz, Richard J. Zdrahala
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Patent number: 6787179Abstract: The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.Type: GrantFiled: June 29, 2001Date of Patent: September 7, 2004Assignee: Ethicon, Inc.Inventors: Debra A. Timm, Henry K. Hui, Mark B. Roller, Mora C. Melican, Syed Hossainy
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Publication number: 20040134790Abstract: Applicant submits herewith an abstract of the invention retyped on a separate page in conformation with U.S. practice. The abstract is taken from that appearing on the cover of the published international application.Type: ApplicationFiled: February 3, 2004Publication date: July 15, 2004Inventors: Georg Gosheger, Jens Sass
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Publication number: 20040109937Abstract: The invention relates to a method for producing bioactive implant surfaces consisting of metallic or ceramic materials, to be used for implants such as artificial joints or very small implants such as so-called stents. The invention also relates to implants produced according to this method.Type: ApplicationFiled: August 15, 2003Publication date: June 10, 2004Inventors: Herbert P. Jennissen, Maria Chatzinikolaidou, Heike Rumpf
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Patent number: 6733503Abstract: The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. The invention further relates to a medical implant coated in said method and to a device for use in said method.Type: GrantFiled: January 9, 2001Date of Patent: May 11, 2004Assignee: IsoTis N.V.Inventors: Pierre Jean François Layrolle, Klaas de Groot, Joost Dick de Bruijn, Clemens A. van Blitterswijk, Yuan Huipin
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Publication number: 20040088052Abstract: A method and apparatus for a prosthesis. At least a portion of the prosthesis is made from a ceramic that is treated with ion implantation, which causes a controllable, bilateral compressive stress of the ceramic. A diamond-like-coating (DLC) can be coated on the ceramic and in the same chamber as the ion implantation. After treating by ion implantation and coating with DLC, the ceramic will be strengthened and have a low coefficient of friction and thereby be made much less likely to fracture under load.Type: ApplicationFiled: November 6, 2002Publication date: May 6, 2004Applicant: Southwest Research InstituteInventor: Geoffrey Dearnaley
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Patent number: 6730349Abstract: The present invention has several plausible embodiments. In one embodiment an apparatus for coating a medical device is provided. This apparatus includes a coating chamber, a vibrating structure within the coating chamber the vibrating structure capable of suspending a medical device positioned in the coating chamber, and a coating source, the coating source positioned to introduce coating into the coating chamber. In another embodiment a method of coating a medical device is provided. This method includes moving a medical device into a predetermined coating area, vibrating a structure below the medical device, the vibration of the structure forcing the medical device away from the vibrating structure, and coating at least a portion of the medical device that has moved away from the vibrating structure.Type: GrantFiled: March 1, 2002Date of Patent: May 4, 2004Assignee: SciMed Life Systems, Inc.Inventors: Marlene C. Schwarz, Stanley Tocker
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Patent number: 6723380Abstract: The present invention is to provide a method of making a polymer compound material by coating an inorganic material on the surface of a polymer. The method provided by the present invention comprises the step of spraying a high volatile solvent to a chipped polymeric matrix to slightly dissolve the surface of the matrix, and the step of adding inorganic material powders to let the powders be coated on the surface of the matrix layer by layer so as to form the polymer compound material.Type: GrantFiled: August 7, 2002Date of Patent: April 20, 2004Assignee: Biotech One Inc.Inventor: How Tseng
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Publication number: 20040068323Abstract: An implant and a process of modifying an implant surface, which implant is in particular a hip implant, a tooth implant, a bone screw, fixation pin or a fixation nail (pin-fixation), comprising a metallic base body (1), which implant has a surface modified by a tantalum or niobium, for the formation of a surface modification (4) where at least the tissue-friendly metal is alloyed with the surface and constitutes a uniform, diffusion-tight outer zone (2) on the body (1), which outer zone (2) has a higher ductility than the metallic base body (1) in order to obtain a tissue-friendly implant with increased fatigue strength.Type: ApplicationFiled: August 26, 2003Publication date: April 8, 2004Inventor: John Christensen
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Patent number: 6709694Abstract: The invention relates to the coloring of ceramics by means of ionic or complex-containing solutions. Solutions preferred for this contain defined concentrations of at least one of the salts or complexes of the rare earth elements or the elements of the subgroups. The invention also relates to a kit, which comprises at least one stock bottle with such a coloring solution, a receptacle for the coloring as well as optionally a screen.Type: GrantFiled: September 26, 2001Date of Patent: March 23, 2004Assignee: 3M ESPE AGInventors: Daniel Suttor, Holger Hauptmann, Robert Schnagl, Sybille Frank
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Patent number: 6706654Abstract: A pressable glass ceramic which contains lithium silicate glass and leucite is disclosed. Also, disclosed is the combination of leucite and a lithium silicate glass to stably increase the coefficients of thermal expansion of the resulting glass composition, and the preparation of leucite suitable for addition to the glass composition. Also disclosed are methods for fabricating glass ceramic and dental products from the pressable glass ceramic.Type: GrantFiled: April 19, 2002Date of Patent: March 16, 2004Assignee: Elephant Dental B.V.Inventor: Joseph Maria van der Zel