Inorganic Oxygen-containing Compound Containing Layer Formed (e.g., Hydroxyapatite, Ceramic, Glass) Patents (Class 427/2.27)
  • Patent number: 10227697
    Abstract: A titanium 6 A1/4V alloy is provided with a surface topography that is similar to the Osseotite® surface produced on commercially pure titanium. Native oxide is removed from the Ti 6A1/4V alloy, followed by contacting the metal at ambient temperature with an aqueous hydrochloric acid solution containing a relatively small amount of hydrofluoric acid.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: March 12, 2019
    Assignee: Biomet 3I, LLC
    Inventors: T. Tait Robb, Bruce Berckmans, III, Ross W. Towse, Robert L. Mayfield
  • Patent number: 10118827
    Abstract: The invention relates to a synthetic bone material and a process for making the same. The synthetic bone material may comprise multiple phases of calcium phosphate. Another aspect of the invention is a porous filter, and the method of making the same, and wherein the porous filter is substantially similar to the process for forming the synthetic bone material.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: November 6, 2018
    Inventors: Reed A. Ayers, Nina L. Vollmer
  • Patent number: 9839720
    Abstract: The present invention discloses a coating for a medical implant, wherein at least a part of said coating contains an osseointegration agent and the same and/or a different part of the coating contains an antimicrobial metal agent.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: December 12, 2017
    Assignee: Smith & Nephew, Inc.
    Inventors: Lu Gan, Marcus L. Scott, Shilesh C. Jani
  • Patent number: 9730863
    Abstract: The invention refers to a method for producing a dental restoration comprising a lithium silicate glass or glass ceramic as well as a dental restoration inself. The invention further refers to a ingot with the same composition having a defined strength.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: August 15, 2017
    Assignees: Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V., Vita Zahnfabrik H. Rauter GmbH & Co. KG, DeguDent GmbH
    Inventors: Bernhard Durschang, Jörn Probst, Norbert Thiel, Michael Gödiker, Markus Vollmann, Udo Schusser, Michael Hackner
  • Patent number: 9517187
    Abstract: The present disclosure relates to a method for coating a surface of a titanium implant with low crystalline hydroxyapatite having network- or island-like morphology and to an implant coated by such method.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: December 13, 2016
    Assignee: Osstemimplant Co., Ltd.
    Inventors: Kyung Won Ha, Gyu Ok Choi
  • Patent number: 9517128
    Abstract: A bioelectronic device and method of making is disclosed. The device includes a scaffold formed via 3D printing. The device also includes a biologic and an electronic device formed via 3D printing, the biologic and electronic device being interweaved with or coupled to the scaffold. The electronic component may e.g., include at least one of hard conductors, soft conductors, insulators and semiconductors. The scaffold may be formed of at least one of synthetic polymers and natural biological polymers. The biologic may include at least one of animal cells, plant cells, cellular organelles, proteins and DNA (including RNA).
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: December 13, 2016
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Michael C. McAlpine, Manu Sebastian-Mannoor, Yong Lin Kong, Blake N Johnson
  • Patent number: 9498337
    Abstract: An intervertebral implant, particularly an intervertebral implant comprising local degradable hydroxyl apatite/metal block and based on a support mounting model of porous hydroxyl apatite with metal powders held for sintering and molding, guides osseous tissues to grow in porous metal and is steadily merged in upper and lower bones when the implanted hydroxyl apatite is gradually degraded in a certain period.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: November 22, 2016
    Assignee: METAL INDUSTRIES RESEARCH & DEVELOPMENT CENTRE
    Inventors: Wei-Ching Wang, Meng-Xiu Wu, Fu-Shan Wang, Tzyy-Ker Sue, Wei-Te Chen, Wei-Jen Shih
  • Patent number: 9371231
    Abstract: An apatite crystal is a single crystal expressed by a general formula (M2)5(PO4)3X. In this formula, M2 indicates at least one type of element selected from the group consisting of bivalent alkaline-earth metals and Eu, and X indicates at least one type of element or molecule selected from the group consisting of halogen elements and OH. And the single crystal is of a tubular shape. The outer shape of the apatite may be a hexagonal prism. The shape of an opening of a hole formed in the upper surface or lower surface of the hexagonal prism may be a hexagon.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: June 21, 2016
    Assignee: KOITO MANUFACTURING CO., LTD.
    Inventors: Kiminori Enomoto, Hisayoshi Daicho, Yu Shinomiya
  • Patent number: 9327977
    Abstract: An apatite crystal is a single crystal expressed by a general formula (M2)5(PO4)3X. In this formula, M2 indicates at least one type of element selected from the group consisting of bivalent alkaline-earth metals and Eu, and X indicates at least one type of element or molecule selected from the group consisting of halogen elements and OH. And the single crystal is of a tubular shape. The outer shape of the apatite may be a hexagonal prism. The shape of an opening of a hole formed in the upper surface or lower surface of the hexagonal prism may be a hexagon.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: May 3, 2016
    Assignee: KOITO MANUFACTURING CO., LTD.
    Inventors: Kiminori Enomoto, Hisayoshi Daicho, Yu Shinomiya
  • Patent number: 9237989
    Abstract: A method of coating an article includes the steps of providing a powder comprising coated particles; and spray coating the powder onto a surface of the article to form a composite coating. The spray coating may be carried out by combustion spraying, gas plasma spraying, including vacuum plasma spraying (VPS), and cold spraying. The article may be an implant for surgical or dental use. The powder may include particles of metal coated calcium phosphates, especially metal coated hydroxyapatite. The particles may include bioactive agents.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: January 19, 2016
    Assignee: Taragenyx Limited
    Inventors: Rehan Ahmed, Gerardus Hendricus Markx
  • Patent number: 9216929
    Abstract: The invention relates to a method for producing hydroxyapatite coated ceramics components. In a first step of the inventive method the ceramic component is provided with a Ti coating and in a second step a hydroxyapatite is applied to the Ti coating. The invention further relates to hydroxyapatite coated ceramic components produced according to the inventive method.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: December 22, 2015
    Assignee: Ceram Tec GmbH
    Inventors: Hans Andersch, Wolfgang Burger, Herbert Richter, Gert Richter
  • Patent number: 9198742
    Abstract: A method of increasing the hydrophilicity of an implant to be implanted into living bone. The method comprises the act of depositing non-toxic salt residuals on the surface of the implant by exposing the surface to a solution including the non-toxic salts. The method further comprises the act of drying the implant.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: December 1, 2015
    Assignee: Biomet 3i, LLC
    Inventors: Jacqueline K. Marks, Robert L. Mayfield, Ross W. Towse
  • Publication number: 20150118649
    Abstract: The present invention relates to a surface treatment method for an implant, comprising: providing an implant; and forming a ceramic layer on a surface of the implant by atomic layer deposition, wherein the ceramic layer has a thickness of 5-150 nm; a root mean square roughness increase in a range of 15 nm or less; and a friction coefficient of 0.1-0.5. The ceramic layer formed on the surface of the implant can fully encapsulate the surface of the implant with excellent uniformity to effectively block the free metal ions dissociated from the implant. Moreover, it has anti-oxidation and anti-corrosion effects, and greatly enhances the biocompatibility of the implant.
    Type: Application
    Filed: May 20, 2014
    Publication date: April 30, 2015
    Applicant: National Taiwan University
    Inventors: Sheng-Hao HSU, Wan-Yu TSENG, Li-Deh LIN, Ming-Shu LEE, Ming-Hung TSENG, Wei-Fang SU, Feng-Yu TSAI, Min-Huey CHEN
  • Patent number: 9011965
    Abstract: The present invention provides a coating comprising a bioactive material and an antimicrobial agent, wherein the concentration of said antimicrobial agent varies throughout the thickness of the coating.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: April 21, 2015
    Assignee: Smith & Nephew, Inc.
    Inventors: Lu Gan, Marcus L. Scott, Shilesh C. Jani, Laura S. Whitsitt
  • Publication number: 20150080303
    Abstract: The present invention relates to a device having osteoinductive and osteoconductive properties in vivo comprising a carrier containing calcium phosphate and an osteoinductive protein, wherein the carrier is homogenously coated with the protein. Moreover, the present invention relates to a method for the production of a device having osteoinductive and osteoconductive properties in vivo. The invention encompasses a pharmaceutical composition comprising the device of the invention or a device which is obtainable by the method of the invention and relates to the use of the device for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation. Finally, the invention relates to a kit comprising the device of the invention or a device which is obtainable by the method of the invention.
    Type: Application
    Filed: September 27, 2013
    Publication date: March 19, 2015
    Inventors: Ulrich Kohnert, Sylke Pohling, Klaus Hellerbrand, Peter Happersberger
  • Publication number: 20150079408
    Abstract: A fluorine-containing porcelain, such as a porcelain material comprising a fluorine-doped glass, is provided for use in dental applications. The porcelain may be used to overlie at least a portion of a dental component such that an interface between the porcelain and the dental component comprises a fluorinated metal oxide. Methods for producing such fluorine-containing porcelains and for treating dental components with such fluorine-containing porcelains are also provided. The fluorine-containing porcelain may exhibit enhanced bonding to the underlying dental component such as a high strength ceramic.
    Type: Application
    Filed: April 18, 2013
    Publication date: March 19, 2015
    Inventors: Jeffrey Robert Piascik, Brian R. Stoner
  • Publication number: 20150073551
    Abstract: Implantable biomimetic ligaments suitable for use in ligament replacement, including, but not limited to, that of the anterior cruciate ligament (ACL) are provided. The replacement implants consist of a biocompatible degradable polymeric scaffold seeded with mesenchymal stem cells (or a combination of different phenotypes). The use of materials such as polylactic acid, fibrin, and nanohydroxyapatite particles, area-dependent compositional modifications, surface topography, biochemical manipulations, and selective growth environments in vitro, allows the scaffold to be populated with the cells mimetic of the native tissue. The mechanical properties of the scaffold support the development of subchondral bone, mineralized fibrocartilage, non-mineralized fibrocartilage, and the ligament proper. The scaffold can be rolled up, transitioning the two-dimensional planar scaffold to a three-dimensional graft for implantation.
    Type: Application
    Filed: September 10, 2013
    Publication date: March 12, 2015
    Inventor: Andrew Uehlin
  • Patent number: 8951597
    Abstract: The present invention provides a functionally graded glass/ceramic/glass sandwich system especially useful in damage resistant, ceramic dental and orthopedic prosthesis. The functionally graded glass/substrate/glass composite structure comprises an outer (aesthetic) residual glass layer, a graded glass-ceramic layer, and a dense interior ceramic. The functionally graded glass/substrate/glass composite structure may further comprise a veneer on an exterior surface. The present invention also provides a method for preparing a functionally graded glass/ceramic/glass sandwich system. A powdered glass-ceramic composition or a glass tape is applied to the accessible surfaces of a dense alumina substrate to thereby substantially cover the substrate surfaces. The glass of the composition has a CTE similar to that of the substrate material. The glass-ceramic composition is infiltrated into the dense substrate by heating the assembly to temperatures 50-700° C. below the sintering temperature of the substrate.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: February 10, 2015
    Assignee: New York University
    Inventors: Yu Zhang, Jae-Won Kim, Van P. Thompson
  • Publication number: 20150038899
    Abstract: A bone implantable medical device made from a biocompatible material, preferably comprising titania or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of accelerated Neutral Beam irradiation, wherein the Neutral Beam is derived from an accelerated gas cluster ion beam irradiation for improving bone integration.
    Type: Application
    Filed: August 22, 2012
    Publication date: February 5, 2015
    Inventors: Laurence B. Tarrant, Richard C. Svrluga, Sean R. Kirkpatrick
  • Patent number: 8920869
    Abstract: This invention provides an Osseo-inductive metal implant for a living body and the producing method thereof and, more particularly, the Osseo-inductive metal implant for a living body according to the present invention is produced by forming, on the surface of the metal implant, the layer of metal oxide and the layer of bio-active material injected.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: December 30, 2014
    Assignee: Korea Institute of Machinery and Materials
    Inventors: Eung-Sun Byon, Yong-Soo Jeong, Jong-Kuk Kim, Young-Taeg Sul, Beom-Seok Chang, Lee-Ra Cho
  • Publication number: 20140377449
    Abstract: The invention relates to a method for the surface treatment of a biologically inert titanium implant to be placed in contact with a bone of the human body, which involves allowing body fluids, such as the inorganic portion of human blood plasma, to naturally deposit, onto the titanium implant, a calcium phosphate film having the formula Ca5(PO4)3(OH), in the form of hydroxyapatite, with a view to rendering the biologically inert titanium biologically active so as to enable the bone to chemically bond to the implant, thus promoting osseointegration, the method including an operation that involves submerging the titanium in a sodium hydroxide (NaOH) solution, wherein said submersion causes the formation of a film of hydrated titanium oxides (HTiO3—) on the titanium, which in turn causes hydroxyl groups (TiOH) to appear, thus enabling the deposition of said calcium phosphate film.
    Type: Application
    Filed: November 14, 2012
    Publication date: December 25, 2014
    Inventor: Alexandre Barbas
  • Publication number: 20140370461
    Abstract: A method of increasing the hydrophilicity of an implant to be implanted into living bone. The method comprises the act of depositing non-toxic salt residuals on the surface of the implant by exposing the surface to a solution including the non-toxic salts. The method further comprises the act of drying the implant.
    Type: Application
    Filed: August 27, 2014
    Publication date: December 18, 2014
    Inventors: Jacqueline K. Marks, Robert L. Mayfield, Ross W. Towse
  • Publication number: 20140327166
    Abstract: A dental prosthesis, typically formed in a press to metal process, includes application of a porcelain composition sufficient to form a veneer on a dental prosthesis supporting metal structure, the composition having an integrated tooth-like translucency providing an aesthetic appearance. The composition is formed of a dentin frit and an enamel frit, typically sintered into a desired ingot shape including an amount of composition sufficient to veneer the prosthesis. The porcelain composition is a component of a kit that includes opaquers, other porcelains and stains useful in finishing to provide an aesthetic prosthesis.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 6, 2014
    Inventors: Christopher C.Y. CHU, Slawomir BANASIAK
  • Publication number: 20140315149
    Abstract: The present invention provides a membrane for guided regeneration of bone and tissue comprising an organic base material and a new bone formation guide layer on one or both sides of the organic base material, the new bone formation guide layer containing a hydrophilic polymer and calcium phosphate.
    Type: Application
    Filed: November 30, 2012
    Publication date: October 23, 2014
    Inventors: Hiroko Noda, Tetsushi Maruyama
  • Publication number: 20140308334
    Abstract: In one aspect, there is provided a method for preparing a biocompatible coated substrate. The method generally includes: depositing nucleation amorphous calcium phosphate sites on at least a portion of an outer surface of a substrate by: exposing at least the portion of the outer surface to a mixture having a favorable Ca/P molar ratio, and irradiating with microwave energy; and, stabilizing the deposited nucleation amorphous calcium phosphate sites on the portion of the outer surface. In another aspect, there is provided herein a method for preparing a biocompatible coated substrate.
    Type: Application
    Filed: October 31, 2012
    Publication date: October 16, 2014
    Applicant: The University of Toledo
    Inventors: Sarit B. Bhaduri, Vijay K. Goel, Huan Zhou
  • Publication number: 20140308628
    Abstract: The present invention relates to a multi-layer material comprising a metal or metal alloy substrate, the metal or alloy substrate being coated with an intermediate layer comprising at least one ceramic or crystalline, or partially crystalline, structure, including a metal or a metal alloy, said intermediate layer being coated with a layer of calcium phosphate having a cellular nanometric structure, and uses thereof. The present invention relates to the method for preparing such a material by autocatalytic deposition of a layer of calcium phosphate comprising a cellular nanometric surface structure.
    Type: Application
    Filed: November 12, 2012
    Publication date: October 16, 2014
    Applicant: Centre National de la Recherche Scientifique (C.N.R.S.)
    Inventors: Adele Carradò, Geneviève Pourroy, Wafa Abdel-Fattah
  • Patent number: 8858979
    Abstract: A composite material including ultra-high molecular weight polyethylene in conjunction with a biologically active agent is described. The biologically active agent can be, for example, an anti-osteolytic agent such as a bisphosphonate. The composite material can be utilized in forming implants such as total joint replacement implants. The biologically active agent can be released from the composite material either from the bulk or from wear particles released from the surface of the implant component during use. Upon release, the biologically active agent can carry out the intended function of the agent.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: October 14, 2014
    Assignee: Clemson University
    Inventors: John D. DesJardins, Martine LaBerge, Cassandra Wright-Walker
  • Patent number: 8852672
    Abstract: A method of increasing the hydrophilicity of an implant to be implanted into living bone. The method comprises the act of depositing non-toxic salt residuals on the surface of the implant by exposing the surface to a solution including the non-toxic salts. The method further comprises the act of drying the implant.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: October 7, 2014
    Assignee: Biomet 3i, LLC
    Inventors: Jacqueline K. Charlton, Robert L. Mayfield, Ross W. Towse
  • Publication number: 20140296996
    Abstract: Provided herein are a membrane-type artificial scaffold for guided bone regeneration (GBR) and a method for fabricating the same. The membrane-type artificial scaffold according to the present invention comprises: a first layer made of at least one fiber layer arranged in parallel with each other with a first spacing therebetween such that the fiber layer contacts a bone tissue in vivo; and a second layer stacked on the first layer and made of at least one fiber layer arranged parallel to each other with a second spacing therebetween such that the fiber layer contacts a soft tissue in vivo. The first spacing is larger than the second spacing.
    Type: Application
    Filed: October 17, 2012
    Publication date: October 2, 2014
    Inventors: Jin-Hyung Shim, Dong-Woo Cho, Jeoung Yong Kim, Jong Young Kim
  • Publication number: 20140255874
    Abstract: A method of manufacturing a functionalized implant, in particular a dental implant, is provided, including first providing a substrate for the implant and applying a highly porous, hydrophilic coating which contains at least one of the following materials for functionalization: zirconium or titanium or zirconium alloy or titanium alloy, zirconium oxide or titanium oxide, calcium phosphate, calcium titanate or calcium zirconate. Further provision is made for a functionalized implant, in particular a dental implant.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 11, 2014
    Applicant: DOT GMBH
    Inventors: Hans-Georg Neumann, Ulrich Lembke
  • Patent number: 8821911
    Abstract: The present invention discloses a coating for a medical implant, wherein at least a part of said coating contains an osseointegration agent and the same and/or a different part of the coating contains an antimicrobial metal agent.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: September 2, 2014
    Assignee: Smith & Nephew, Inc.
    Inventors: Lu Gan, Marcus L. Scott, Shilesh C. Jani
  • Patent number: 8815328
    Abstract: Methods are presented for a continuous, two-step, phase sequenced deposition of hydroxyapatite film over the surface of the substrate.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: August 26, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Richard E. Riman, Alexander Burukhin, Eugene Zlotnikov, Dan Haders
  • Patent number: 8815327
    Abstract: The present invention provides a functionally graded glass/ceramic/glass sandwich system for use in damage resistant, ceramic and orthopedic prosthesis. The functionally graded glass/substrate/glass composite structure comprises an outer residual glass layer, a graded glass-ceramic layer, and a dense interior ceramic. The functionally graded glass/substrate/glass composite structure may further comprise a veneer on an exterior surface. The present invention also provides a method for preparing a functionally graded glass/ceramic/glass sandwich system. A powdered glass-ceramic composition is applied to the accessible surfaces of a presintered zirconia substrate to thereby substantially cover the substrate surfaces. The glass of the composition has a CTE similar to that of the substrate material. The glass-ceramic composition is infiltrated into and densifies the substrate by heating the assembly to at least the sintering temperature of the substrate.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: August 26, 2014
    Assignee: New York University
    Inventors: Yu Zhang, Jae-Won Kim
  • Publication number: 20140186441
    Abstract: A biocompatible, resorbable composite for osteosynthesis includes osteoconductive particles dispersed within a porous polymer matrix having a plurality of fluid passageways that expose at least a portion of a plurality of the osteoconductive particles to an exterior of the polymer matrix. The composite may further include a chemical additive incorporated within the polymer matrix, the chemical additive being configured to modify one or more of acidity, degradation rate, melting point, hydrophilicity, and hydrophobicity of the polymer matrix. A method for making the composite includes mixing the osteoconductive particles with polymer material and the chemical additive to form a mixture and treating the mixture to bind the osteoconductive particles with the polymer material to create a solid unit.
    Type: Application
    Filed: March 13, 2013
    Publication date: July 3, 2014
    Applicant: DePuy Synthes Products, LLC
    Inventors: Stefan Beck, Lorenz Niederberger, Nico Stohler
  • Patent number: 8765211
    Abstract: Disclosed herein are methods of treating an article surface. The method comprises delivering a polymer and drug to a medical implant having a porous surface and using at least one particle stream from at least one fluid jet to subsequently remove the polymer from the outer surface of the metal substrate, thereby retaining the therapeutic agent and polymer within the pores of the implant.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: July 1, 2014
    Assignee: Enbio Limited
    Inventors: Liam O'Neill, Caroline O'Sullivan
  • Publication number: 20140178639
    Abstract: Body made of a ceramic material, the body having as an integral part thereof a surface region reaching from the surface of the body down to a predetermined depth. According to the invention, the surface region is enriched with a magnesium component thereby forming a hydrophilic surface area.
    Type: Application
    Filed: June 22, 2012
    Publication date: June 26, 2014
    Applicant: Straumann Holding AG
    Inventor: Simon Berner
  • Publication number: 20140180434
    Abstract: A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.
    Type: Application
    Filed: December 20, 2012
    Publication date: June 26, 2014
    Inventors: Thomas E. Day, Erik M. Erbe, Steven B. Jung
  • Publication number: 20140127392
    Abstract: A method of forming an implant to be implanted into living bone is disclosed. The method comprises the act of roughening at least a portion of the implant surface to produce a microscale roughened surface. The method further comprises forming a nanoscale roughened surface on the microscale roughened surface. The method further comprises the act of depositing discrete nanoparticles on the nanoscale roughened surface though a one-step process of exposing the roughened surface to a solution including the nanoparticles. The nanoparticles comprise a material having a property that promotes osseointegration.
    Type: Application
    Filed: January 9, 2014
    Publication date: May 8, 2014
    Applicant: Biomet 3I, LLC
    Inventors: Bruce Berckmans, III, Ross W. Towse, Robert L. Mayfield
  • Publication number: 20140099353
    Abstract: A medical implant which, on at least part of its surface, has a coating with an osteoinductive and/or osteoconductive top layer based on calcium phosphate and/or calcium carbonate, wherein an antibiotic active substance, which is soluble in aqueous medium, is coated over the osteoinductive and/or osteoconductive top layer in patches, leaving gaps on the osteoinductive and/or osteoconductive top layer.
    Type: Application
    Filed: May 30, 2012
    Publication date: April 10, 2014
    Applicant: DERU GmbH
    Inventor: Helmut D. Link
  • Patent number: 8663337
    Abstract: A process for forming a ceramic layer comprising a compound of a metal on a deposition surface of a workpiece comprises providing a reactive gas, selecting the amounts of a vapor of the metal and ions of the metal relative to each other, generating the metal vapor, and projecting an ion beam of the metal ions. The metal vapor, the metal ions, and the reactive gas form the ceramic layer with a desired structure. The process may include the step of controlling a deposition surface temperature. In one embodiment, the metal vapor comprises zirconium vapor and the ion beam comprises zirconium ions. The relative amounts of the zirconium vapor and the zirconium ions are selected to form a zirconia ceramic layer on the deposition surface. The zirconia may have multiple crystal phases that are formed according to a predetermined ratio.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: March 4, 2014
    Assignee: Zimmer, Inc.
    Inventors: Jeffrey P. Anderson, Oludele O. Popoola
  • Patent number: 8597718
    Abstract: An ultrathin film of calcium phosphate crystals having a thickness of 200 nm or less on a surface of a solid substrate, and a method for preparing the same are disclosed. Further, an amorphous dendritic extension used as an intermediate material in preparation of the ultrathin film of calcium phosphate and a method for forming the same are disclosed. The ultrathin film of calcium phosphate crystals can be coated on the surface of the solid substrate while substantially maintaining surface roughness of the solid substrate. The method employs calcium phosphate ion solutions at low temperature.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: December 3, 2013
    Assignee: Seoul National University Industry Foundation
    Inventor: Hyun Man Kim
  • Patent number: 8597676
    Abstract: The present invention is based on that local administration of lithium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising lithium ions and a method for the manufacture thereof. A blasting powder comprising lithium ions, a method for locally increasing bone formation, and the use of lithium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: December 3, 2013
    Assignee: Astra Tech AB
    Inventors: Stig Hansson, Ingela Petersson
  • Patent number: 8556957
    Abstract: A system for treating a vascular condition includes a stent including hydroxyapatite fibers interwoven to define a stent lumen. Another aspect of the invention is a method of manufacturing a stent by forming hydroxyapatite fibers and biodegradable polymeric fibers, and interweaving the fibers to form a stent wall. The hydroxyapatite fibers can be formed by a sol-gel process, followed by spinning of the gel to form the hydroxyapatite fibers.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: October 15, 2013
    Assignee: Medtronic Vascular, Inc.
    Inventor: Iskender Bilge
  • Patent number: 8556969
    Abstract: We describe herein biocompatible single crystal Cu-based shape memory alloys (SMAs). In particular, we show biocompatibility based on MEM elution cell cytotoxicity, ISO intramuscular implant, and hemo-compatibility tests producing negative cytotoxic results. This biocompatibility may be attributed to the formation of a durable oxide surface layer analogous to the titanium oxide layer that inhibits body fluid reaction to titanium nickel alloys, and/or the non-existence of crystal domain boundaries may inhibit corrosive chemical attack. Methods for controlling the formation of the protective aluminum oxide layer are also described, as are devices including such biocompatible single crystal copper-based SMAs.
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: October 15, 2013
    Assignee: Ormco Corporation
    Inventor: Alfred David Johnson
  • Publication number: 20130266616
    Abstract: Bone graft materials include a bone-grafting material, which encourages regeneration of a missing bone tissue while being absorbed by the missing bone tissue, and a coating material, which is composed of at least one selected from the group consisting of magnesium, calcium hydroxyapatite, and mixtures thereof.
    Type: Application
    Filed: July 10, 2012
    Publication date: October 10, 2013
    Inventor: Ki-Deog Park
  • Patent number: 8536078
    Abstract: Lithium silicate glass ceramics and glasses containing at least 6.1 wt.-% ZrO2 are provided which can advantageously be applied to zirconium oxide ceramics in particular by pressing-on in the viscous state and forming a solid bond with the zirconium oxide ceramics.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: September 17, 2013
    Assignee: Ivoclar Vivadent AG
    Inventors: Christian Ritzberger, Ricardo Dellagiacomo, Marcel Schweiger, Harald Burke, Wolfram Holand, Volker Rheinberger
  • Publication number: 20130230640
    Abstract: A new composition and medical implant made there from comprises a thick diffusion hardened zone, and layered ceramic surface. Orthopedic implants comprising the new composition, methods of making the new composition, and methods of making orthopedic implants comprising the new composition are disclosed.
    Type: Application
    Filed: March 29, 2013
    Publication date: September 5, 2013
    Applicant: Smith & Nephew, Inc.
    Inventors: Vivek Devidas PAWAR, Shilesh C. JANI, Carolyn L. WEAVER
  • Patent number: 8512732
    Abstract: An object of the present invention is to provide a method for producing bioactive composites having imparted thereto bioactivity, to thereby form and grow in vivo or in vitro a coating layer containing a calcium phosphate compound as the major component with a high adhesion strength on the surface of various types of porous substrates such as a porous shaped body comprising an organic polymer. The means for solving the problem is characterized by comprising at least (1) a step of immersing a porous substrate in a solution containing at least calcium ions and hydrogenphosphate ions, thereby distributing the solution to the inside of at least a part of the pores of the substrate, and (2) a step of depositing fine particles containing a calcium phosphate compound as the major component inside the pores into which the solution is introduced.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: August 20, 2013
    Assignee: Kyoto University
    Inventors: Takeshi Yao, Mitsuhiro Hibino, Takeshi Yabutsuka
  • Publication number: 20130209966
    Abstract: An integrated dental porcelain system for making dental prostheses and restorations is provided. The system includes three universal major components: a) opaque porcelain composition; b) pressable dentin ingot; and c) veneering porcelain composition that can be used interchangeably for making restorations. Techniques for making the prostheses and restorations include porcelain fused-to-metal (PFM), press-to-metal (PTM), and either pressed and/or machined all-ceramic methods. The system uses both a hand-layering of veneering porcelain (PFM technique) and a hot-pressing process (PTM and all-ceramic technique) to fabricate the prostheses and restorations.
    Type: Application
    Filed: March 18, 2013
    Publication date: August 15, 2013
    Applicant: DENTSPLY INTERNATIONAL INC.
    Inventors: Christopher Chu, Slawomir Banasiak, Victoriya Shtessel-Nemzer
  • Publication number: 20130209951
    Abstract: A fluoride treated medical implant, such as a dental component, is provided, the medical implant comprising fluorinated metal oxide on the substrate surface. A method for the preparation of such treated implants is also provided, the method involving exposure of the medical implant to a fluorine-containing reagent. A dental structure is also provided, which includes a first dental component comprising a fluorinated metal oxide layer on its surface, a silane coupling agent, a dental cement, and a second dental component having a surface bonded to the dental cement. An additional dental structure, which includes a first dental component comprising a fluorinated metal oxide layer on its surface, a dental cement, and a second dental component having a surface bonded to the dental cement is also provided.
    Type: Application
    Filed: October 20, 2011
    Publication date: August 15, 2013
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: Jeffrey Robert Piascik, Brian R. Stoner