Flexible Web, Sheet, Film, Or Filament Base (e.g., Fabric, Bandage, Suture, Transdermal Patch, Orthopedic Cast Tape) Patents (Class 427/2.31)
  • Patent number: 10471394
    Abstract: A method for producing a microporous membrane includes providing a microporous starting membrane having outer surfaces and pores with inner surfaces extending between the outer surfaces of the membrane and having a microporous starting membrane permeability. The method impregnates the membrane with an impregnating solution consisting essentially of a solvent and a polymer. The polymer is an organic substance with an average molecular weight of at least 500 g/mol and may be selected from the group consisting of poly(2-ethyloxazoline), polyvinylpyrrolidone-vinyl acetate (PVP-VA) and mixtures thereof. The method then includes irradiating the impregnated membrane with electron beam radiation to provide a crosslinked reaction product constituting a three-dimensional network formed of the microporous starting membrane and the polymer without any decomposition of the microporous starting membrane.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: November 12, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Volkmar Thom, Bjoern Hansmann, Tobias Foster
  • Patent number: 10196762
    Abstract: The present disclosure relates to a method of forming yarns and preparing surgical devices therefrom. The yarns include at least one first filament possessing a polymer core and first reactive members known to have click reactivity on a surface thereof and at least one second filament possessing a polymer core and second reactive members known to have click reactivity on a surface thereof. The first and second reactive members are complementary such that they interact to covalently bond the filaments together.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: February 5, 2019
    Assignee: Covidien LP
    Inventor: Jonathan Thomas
  • Patent number: 10092441
    Abstract: A substrate based skin contact material formed from a hydrocolloid having a silicone based component extending over regions of the substrate surface. The adhesive is formed non-continuously over the substrate to provide areas devoid of adhesive to allow appreciable moisture transfer between the skin and substrate and improve the skin friendliness of the material during use and allow convenient removal with avoidance of skin irritation.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: October 9, 2018
    Assignee: CONVATEC LTD
    Inventor: Stewart Lee
  • Patent number: 9880149
    Abstract: A glass pipette such as an electrode for electrophysiological recording is coated with quantum dots. This greatly aids the ability to observe the glass pipette, particular in tissue as the quantum dots provide an excellent performance under two-photon illumination used to visualize objects at depths of hundreds of microns.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: January 30, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Igor L. Medintz, Bertalan K. Andrasfalvy, Kimihiro Susumu, James B. Delehanty, Alan L. Huston, John J. Macklin, Mladen Barbic
  • Patent number: 9364426
    Abstract: Coated microneedle devices and methods of making such devices are provided. In one aspect, a method for coating includes providing a microstructure having at least one surface in need of coating; and applying a coating liquid, which includes at least one drug, to the at least one surface of the microstructure, wherein the surface energy of the coating liquid is less than the surface energy of the surface of the microstructure. The coating liquid may include a viscosity enhancer and surfactant. Microneedles having heterogeneous coatings, pockets, or both are also provided.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: June 14, 2016
    Assignee: Georgia Tech Research Corporation
    Inventors: Harvinder Singh Gill, Mark R. Prausnitz
  • Patent number: 9211106
    Abstract: A tape for securing an ultrasound probe to the skin may include a sonolucent silicone gel for transmitting ultrasound from an ultrasound transducer to the body. A method of manufacturing an adhesive silicone product may include a step of treating the adhesive composition or components of the composition to remove air or prevent the formation of air bubbles, in order to provide a sonolucent adhesive product.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: December 15, 2015
    Assignee: NEORAD AS
    Inventors: Nicolay Berard-Andersen, Gjermund Fjeld Olsen
  • Patent number: 9119894
    Abstract: A method for modifying a non-woven fabric of chitosan fiber. The method includes: adding succinic anhydride to an industrial alcohol, ethanol, or acetone; controlling the mass ratio of succinic anhydride to the non-woven fabric at between 0.8 and 3.5; and stirring the resulting mixture until the succinic anhydride has dissolved to yield a succinic anhydride mixed solution; placing the succinic anhydride mixed solution in a constant temperature shaking bath; heating the succinic anhydride mixed solution; adding an HCl solution to the succinic anhydride mixed solution, and stirring evenly to yield a HCl mixed solution; immersing the non-woven fabric in the HCl mixed solution; dehydrating; immersing the non-woven fabric in ethanol or acetone; immersing the non-woven fabric in anhydrous ethanol or pure acetone; dehydrating; and air drying the non-woven fabric.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: September 1, 2015
    Assignee: QINGDAO JIFA NEW MATERIAL CO., LTD.
    Inventors: Yuhua Huang, Weidong Yang, Hongjun Yi
  • Patent number: 9108987
    Abstract: The present invention relates to a silver/polydiguanide complex and derivatives thereof including silver and polydiguanide having at least two biguanide moieties, wherein the silver is stabilized in an oxidation state of an integer of 0 to 4, a mole ratio between the silver and the polydiguanide is 1:1-4, an average particle diameter of the complex is micrometer or nanometer, and zeta potential of the complex is greater than or equal to zero, a preparation method thereof, and an antibacterial composition for burns or wounds treatment including the same as an active ingredient.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: August 18, 2015
    Assignee: SNU R&DB Foundation
    Inventors: Joon Myong Song, Sukdeb Pal
  • Publication number: 20150148758
    Abstract: The purpose is to provide a mirtazapine-containing transdermal patch capable of suppressing deposition of a crystalline component derived from mirtazapine, deterioration in sense of use, and deterioration in adhesiveness to the skin. The transdermal patch contains a support, a drug-containing layer and a release liner, and the drug-containing layer contains mirtazapine and an organic acid.
    Type: Application
    Filed: May 14, 2013
    Publication date: May 28, 2015
    Applicant: Yutoku Pharmaceutical Industries Co., Ltd.,
    Inventors: Makoto Yoshitake, Kenta Nishimura
  • Publication number: 20150140064
    Abstract: Nano scale collagen particles can be obtained from an embrittling and attrition process that reduces the size of collagen particles to the nano scale. These nano scale collagen particles have many favorable properties such as providing beneficial and enhanced properties for cell seeding and wound healing. The nano scale collagen particles can be included in biocompatible (e.g., biostable or biodegradable) compositions and are useful for wound treatment and management, as well as in cell cultures and tissue engineering implants.
    Type: Application
    Filed: January 27, 2015
    Publication date: May 21, 2015
    Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC
    Inventors: Hengky CHANG, Henry LEUNG
  • Patent number: 9028853
    Abstract: A moisture-permeable glove or other garment protects against user contamination and cross-contamination by providing both rapid and persistent sterilization. Exposure to halogen of inherent NH groups and/or attached hydantoin can form a persistent outer halamine sterilization layer. A second inner halamine layer intercepts any pathogens that penetrate the outer surface. The garment can be single layer, or can include a detachable inner liner. Embodiments are compatible with rapid decontamination using an alcohol-based agent. Some embodiments provide a 180 second 3-log kill rate for at least S. aureus ATCC and E. coli. Embodiments include a moistening agent to activate the halamine. An anti-cut/puncture layer and/or a pathogen barrier layer can also be included. The protective layer can include contiguous layers of soft and hard metal flexed to improve flexibility and Moisture Vapor Transport Rate (MVTR). The pathogen barrier can include urethane and/or CNT fibers. The garment MVTR can be greater than 0.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: May 12, 2015
    Assignee: Warwick Mills Inc.
    Inventor: Charles A. Howland
  • Publication number: 20150125512
    Abstract: A sheet material that can be used as a wound dressing and contains elemental metal particles.
    Type: Application
    Filed: February 26, 2013
    Publication date: May 7, 2015
    Inventors: Marco Wolfstaedter, Birgit Schaefer
  • Publication number: 20150100019
    Abstract: A therapeutic delivery device comprises a layer of biodegradable material wound into a plurality of windings, the plurality of windings comprising an outermost winding defining an internal volume and winding pairs including a first winding pair and a second winding pair. A first therapeutic mass is incorporated in or on the layer the first winding pair and a second therapeutic mass is incorporated in or on the layer along the second winding pair. In one implementation, at least one volume of gas is captured within the internal volume and occupies at least 50% of the internal volume. In one implementation, the windings include perforations.
    Type: Application
    Filed: October 9, 2014
    Publication date: April 9, 2015
    Inventors: Matthew Q. Shaw, Robert F. Wallace
  • Patent number: 8999427
    Abstract: The invention relates to a method for the impregnation of a product consisting of fibrous material and formed from a continuous web (22), the method comprising at least one first step of cutting out a specific zone (24) of the continuous web (22) and at least one second step of applying an impregnation product to the specific zone (24), the first and second steps being carried out simultaneously or virtually simultaneously.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: April 7, 2015
    Assignee: SCA Tissue France
    Inventor: Remy Ruppel
  • Patent number: 8992945
    Abstract: A bio-adhesive supramacromolecular complex of the general formula: wherein R1 is independently selected from the group consisting of an alkane unsubstituted or substituted with alkoxy groups; R2 is independently selected from the group consisting of C1-6 alkyl; R3 and R4 are independently selected from the group consisting of optionally substituted aliphatic or aromatic alkyl; R5 is independently selected from the group consisting of H or C1-6 alkyl; W is a hydrogen-bond accepting functional group-containing entity; Y is a carboxylic acid ester or amide linkage; R is an independently selected peptide linking group; T1, T2, T3 and T4 are independently selected polymer residues; and m1, m2, m3, n1 and n2 are integers selected from at least 25; and wherein P has a molecular weight of about 1×103 to 1×107 and Q has a molecular weight of about 1×103 to 1×107. The complex provides controlled nitric oxide release over a longer period of time than prior art compounds in the locally delivery systems.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: March 31, 2015
    Assignee: University of Toronto
    Inventors: Ping I. Lee, Yan Li
  • Publication number: 20150080802
    Abstract: The present disclosure relates generally to microneedle devices and methods for fabricating microneedles from a biocompatible polymer using photolithography. More particularly, aspects of the present disclosure are directed to the fabrication of microneedle devices using a biocompatible polymer (biopolymer) by way of biocompatible, essentially biocompatible, or substantially biocompatible fabrication techniques.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 19, 2015
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Lifeng Kang, Sui Yung Chan, Jaspreet Singh Kochhar, Wei Jiang Goh
  • Patent number: 8980365
    Abstract: A method of protecting a biologically active substance against denaturation, wherein a liquid (14) containing the active substance and a matrix-forming substance are deposited on a target surface (18) and dried so as to form a solid amorphous matrix (26) with the molecules of the active substance embedded therein, wherein an ink jet printer (10) is used for depositing the liquid (14) on the target surface (16) in the form of droplets (12) having a volume small enough to cause the liquid to dry when it impinges on the target surface (16) and to be held on the target surface through adhesion.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: March 17, 2015
    Inventor: Rogier Biemans
  • Patent number: 8968818
    Abstract: Implantable biocompatible polymeric medical devices include a substrate with an acid or base-modified surface which is subsequently modified to include click reactive members.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: March 3, 2015
    Assignee: Covidien LP
    Inventors: Nadya Belcheva, Ferass Abuzaina, Amin Elachchabi, Mbiya Kapiamba, Ahmad Robert Hadba
  • Patent number: 8968743
    Abstract: The invention concerns the development of a system to deliver vaccines via cutaneous route. The invention more particularly concerns the use of a device comprising a condensation compartment for epicutaneous vaccination. The invention also concerns protocols for epicutaneous vaccination allowing an efficient immune response to be obtained without any skin treatment. The invention can be implemented in any mammal, preferably in human beings, to induce a therapeutic or preventive immune response against any type of antigen.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: March 3, 2015
    Assignee: DBV Technologies
    Inventors: Jorge Ronco, Sylvie Godefroy, Bertrand Dupont
  • Patent number: 8968819
    Abstract: Improvements applied to a textile product, and more particularly wherein the improved product is a woven textile product—fabric containing bioceramic microparticles embedded into the fibers thereof with high capacity of irradiation in the infrared region, provided to be used both in humans and animals, more particularly the invention is related to a textile product containing bioceramic microparticles with high capacity of infrared irradiation which, in contact with the heat of the human body, is capable of transmitting infrared radiation in the range between 3 ?m and 14.8 ?m, preferentially in the 14.8 micron range, said infrared radiation at this wavelength being capable of regulating the blood microcirculation, as the result of its high protection, the blood microcirculation being the nervous center of human and/or animal metabolism.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: March 3, 2015
    Inventor: Mario Hirata
  • Publication number: 20150057605
    Abstract: There is provided glucagon formulations suitable for preparing coatings on microneedle patches for the transdermal delivery of glucagon. The coated patches may be used for the treatment of low blood sugar in diabetic patients. Also provided are glucagon loaded patches, methods for their preparation, and methods of their use.
    Type: Application
    Filed: August 22, 2014
    Publication date: February 26, 2015
    Inventors: Mahmoud Ameri, Peter E. Daddona, Yi Ao
  • Publication number: 20150056255
    Abstract: The present invention relates to a product for at least one of medicinal, cosmetic, coloring or dermatologic use. The product comprises a fibrous plant product and a plant extract which is applied thereto. Further, the invention relates to a corresponding method for producing said product and its use in at least one of medicinal, cosmetic, coloring or dermatologic products or applications or treatments. The plants used may be all plants comprising one or more substances of interest to achieve a desired medicinal, cosmetic, coloring or dermatologic effect.
    Type: Application
    Filed: August 18, 2014
    Publication date: February 26, 2015
    Inventors: Philippe Ragot, Esther Pons, Bernard Mompon, Cedric Rousseau
  • Publication number: 20150050417
    Abstract: Implantable non-bioabsorbable medical devices have an amphiphilic coating for reducing the inflammatory response to the device after implantation.
    Type: Application
    Filed: October 30, 2014
    Publication date: February 19, 2015
    Inventors: Sebastien Ladet, Philippe Gravagna
  • Patent number: 8956685
    Abstract: The present invention relates to methods for forming films. In particular, the present invention relates to the formation of films on a substrate, the substrate having at least one dam portion.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: February 17, 2015
    Assignee: Monosol RX, LLC
    Inventors: Beuford A. Bogue, Alexander Mark Schobel, Keith J. Kendall
  • Publication number: 20150045749
    Abstract: Provided is a transdermal delivery system (for example, in the form of a patch) having a double-layer structure including a drug-containing matrix layer and an adhesive layer, wherein the drug-containing matrix layer is obtained by completely dissolving donepezil using a certain polymer and then formulating along with an adhesive; and a process for preparing the same. The transdermal delivery system according to the present invention does not show any crystallization of donepezil in the formulation, can release donepezil at a uniform rate for a long time, and can inhibit the release dumping phenomenon that occurs in a transdermal delivery system having a single-layer structure.
    Type: Application
    Filed: February 26, 2013
    Publication date: February 12, 2015
    Applicant: SK Chemicals Co., Ltd.
    Inventors: Jong-Seob Im, Yong-Youn Hwang, Won-No Youn, Yeo-Jin Park, Hye-Min Kim, Joon-Gyo Oh, Hun-Taek Kim, Bong-Yong Lee
  • Patent number: 8951598
    Abstract: Nano scale collagen particles can be obtained from an embrittling and attrition process that reduces the size of collagen particles to the nano scale. These nano scale collagen particles have many favorable properties such as providing beneficial and enhanced properties for cell seeding and wound healing. The nano scale collagen particles can be included in biocompatible (e.g., biostable or biodegradable) compositions and are useful for wound treatment and management, as well as in cell cultures and tissue engineering implants.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: February 10, 2015
    Assignee: Empire Technology Development LLC
    Inventors: Hengky Chang, Henry Leung
  • Patent number: 8951599
    Abstract: A wound dressing and a method of making the wound dressing is described herein. The wound dressing is formed of an absorbent substrate formed of one or more layers and a low-adherence layer disposed on the substrate. The low-adherence layer can be disposed within at least a portion of the substrate. The low-adherence layer is formed of a mixture of at least one highly fluorinated polymer and at least one acidic polymer. The at least one highly fluorinated polymer has a fluorine content greater than the fluorine content of the at least one acidic polymer.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: February 10, 2015
    Assignee: International Business Machines Corporation
    Inventors: Robert D. Allen, Christopher E. Bannister, Jere J. Brophy, Richard A. DiPietro
  • Patent number: 8940357
    Abstract: A medical device, such as a medical wire, which includes a coating applied to the surface of the medical wire. The coating includes a base layer bonded to the surface of the medical wire and an at least partially transparent low-friction top coat applied to the base layer. The base layer includes heat activated pigments that change color when heated above a color shifting temperature. In one embodiment, the color of the pigment in one area contrasts with the color of the pigment in an adjacent area without otherwise affecting the low-friction surface of the coating. The areas of different color created in locations along the length of the low-friction coated medical wire form markings which, as an example, enable a surgeon to determine the length of the medical wire inserted into a body by observing the markings on the portion of the marked medical wire located exterior to the body.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: January 27, 2015
    Assignee: Innovatech LLC
    Inventor: Bruce Nesbitt
  • Publication number: 20150024018
    Abstract: A material including a plurality of fatty acid chains cross-linked together and a silver fatty acid salt formed with the fatty acid chains within the material. Methods for forming a material are also included. The silver-containing materials can be utilized alone or in combination with a medical device for the release and local delivery of one or more anti-infective agents.
    Type: Application
    Filed: May 19, 2014
    Publication date: January 22, 2015
    Applicant: MAQUET CARDIOVASCULAR LLC
    Inventors: Keith M. FAUCHER, Hilda ORTIZ, Anthony Richard HORTON, Jocelyn PROWSE, Paul MARTAKOS
  • Patent number: 8936825
    Abstract: The present invention relates to a method for forming a pharmaceutical product, such as a dissolvable film dosage form, onto a surface. Particularly, the present invention relates to a method of forming a pharmaceutical product directly onto the surface of a substrate.
    Type: Grant
    Filed: September 21, 2011
    Date of Patent: January 20, 2015
    Assignee: Monosol RX, LLC
    Inventors: Garry L. Myers, Beuford A. Bogue, Greg Slominski, Kevin Davidson, Laura Miloshoff
  • Publication number: 20150018791
    Abstract: A gap-patterned wound dressing, including a patterned foam structure having a gap patterned side and a non-gap patterned side, wherein the gap patterned side includes a pattern of foam gaps disposed between foam areas dosed with honey, where the pattern of foam gaps is formed by the honey dosed areas; and wherein a wound in contact with the gap patterned side discharges an exudate which substantially collects in the individual ones of the foam gaps causing honey in the individual ones of the honey dosed areas to be substantially dispersed throughout a wound treatment zone.
    Type: Application
    Filed: July 11, 2013
    Publication date: January 15, 2015
    Inventors: GREG DEVENISH, Howard Kenneth Payne
  • Patent number: 8932665
    Abstract: The invention relates to a method for preventing the crystallization of a pharmaceutical in a polymer film, wherein the solvent-containing coating compound, which comprises a matrix-forming polymer or polymer mixture and at least one pharmaceutical and is spread to produce the polymer film, is temporarily dried at temperatures that is at least 10° C. above the melting temperature of the pharmaceutical contained in the coating compound. The maximum temperature is thus higher than that which is required for mere drying and obviates the need for an additional, time-consuming and expensive work step.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: January 13, 2015
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Johannes Josef Leonhard, Walter Mueller
  • Patent number: 8926999
    Abstract: This invention pertains to method for imparting a durable antimicrobial activity to substrates, particularly textiles. An acetate-free metal and peroxide antimicrobial treatment formulation is prepared from a metal derivative, hydrogen peroxide and a source of hydroxide ion. The substrate is treated with the composition and dried to afford the treated substrate with antimicrobial activity. Zinc salts, ions, or complexes are preferred.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: January 6, 2015
    Assignee: Quick-Med Technologies, Inc.
    Inventors: William Toreki, Albina Mikhaylova, Susan Leander, Bernd Liesenfeld, Gerald M. Olderman
  • Publication number: 20150004215
    Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: step A) obtaining an adhesive agent layer composition comprising free ropinirole in an amount which results in a content of 5 to 13.2% by mass in an obtained adhesive agent layer; step B) heating the adhesive agent layer composition at a temperature in a range from 50 to 76° C. for 5 minutes to 24 hours; and step C) cooling the heated adhesive agent layer composition to normal temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the free ropinirole at a supersaturated concentration in a dissolved form.
    Type: Application
    Filed: June 27, 2014
    Publication date: January 1, 2015
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takahito YOSHIZAKI, Kouji Tanaka, Kazunosuke Aida, Terumitsu Kaiho, Nobuo Tsutsumi
  • Patent number: 8920867
    Abstract: The present disclosure relates to self-supporting films for delivery of a therapeutic agent containing at least one hydrophobic polymer and at least one therapeutic agent. Methods of forming the self-supporting films are also disclosed.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: December 30, 2014
    Assignee: Covidien LP
    Inventors: Joshua Stopek, Garrett Ebersole, Amin Elachchabi, Daniel Broom
  • Publication number: 20140378928
    Abstract: The present invention provides a hemostatic composite sponge comprising a porous matrix of a biomaterial and a material enhancing the adherence of said sponge to the applied tissue stably associated with at least one surface of said sponge, a method of producing these sponges and their use in hemostasis.
    Type: Application
    Filed: June 30, 2014
    Publication date: December 25, 2014
    Inventors: Hans Christian Hedrich, Joris Hoefinghoff, Woonza M. Rhee, Atsushi Edward Osawa
  • Publication number: 20140377331
    Abstract: The present invention relates to an antimicrobial wound dressing comprising chitosan-silver nanoparticles and a preparation method thereof The antimicrobial wound dressing is prepared by coating a wound dressing with chitosan and silver and drying the coated wound dressing and has an excellent property of releasing silver nanoparticles in a sustained manner.
    Type: Application
    Filed: December 28, 2012
    Publication date: December 25, 2014
    Inventors: Hyun Seung Ryu, Jun Kyu Park, Jun Hyuk Seo, Young Koo Lee
  • Publication number: 20140378917
    Abstract: The present invention provides transdermal therapeutic systems for dispensing a pharmaceutical product, in particular a pharmaceutical product with a low tendency to spontaneously crystallize. The matrix layer or at least one of the matrix layers in said systems contains a silicone hot-melt adhesive, a pharmaceutical product, and particles made of crosslinked polyvinylpyrrolidone. The invention also relates to a method for producing said transdermal therapeutic systems.
    Type: Application
    Filed: December 28, 2012
    Publication date: December 25, 2014
    Inventors: Horst Dzekan, Hans-Rainer Hoffmann, Michael Horstmann, Walter Mueller, Sandra Wiedersberg
  • Publication number: 20140367324
    Abstract: Filter media, filter devices and methods of making filter media are disclosed. The filter media includes a coating on at least a portion of said outer surface. The coating may be polymeric composition having a molecular chain that includes segments of non-polar groups and segments of at least one of polar groups or segments of ionic groups.
    Type: Application
    Filed: June 15, 2013
    Publication date: December 18, 2014
    Inventors: Yoshikazu Mizobuchi, Jo Anne Alfaro
  • Publication number: 20140364819
    Abstract: The present disclosure relates to a dermal drug delivery platform comprising: a primary wound dressing comprising three-dimensional polymer protuberances that extend upward from the dressing surface to engage the wound. The protuberances comprise at least one biocompatible and/or biodegradable polymer and medicinal nanoparticles. In one embodiment, the medicinal nanoparticles may be metallic and provide surface-area-enhanced galvanic action to drive medicinal ions into the wound bed. Various methods of making the disclosed dermal drug delivery platform, as well as three-dimensional methods of treating a wound using the platform are also disclosed.
    Type: Application
    Filed: June 10, 2014
    Publication date: December 11, 2014
    Inventor: Jay VanDelden
  • Publication number: 20140363564
    Abstract: A method includes contact printing an active composition onto a surface of a release substrate to form a printed surface. The active composition spontaneously dewets the surface of the release substrate to form active deposits on the surface of the release substrate. The active composition comprises an active agent dissolved or dispersed in an aqueous liquid vehicle. A pressure-sensitive adhesive layer is disposed on the printed surface.
    Type: Application
    Filed: December 10, 2012
    Publication date: December 11, 2014
    Inventors: Joseph D. Rule, Jeffrey H. Tokie, Kim B. Saulsbury, Deena M. Conrad-Vlasak, Kanta Kumar
  • Patent number: 8906679
    Abstract: A composite comprising a stem cell; a biodegradable layer, which can provide an environment for the stem cell to grow and to differentiate, and; a N-isopropylacrylamide (NIPAAm), which can polymerize with the biodegradable layer and possess the temperature-responsive character for easy stripping. The present invention further provides a method for treating a patient with a skin defect, consisting of (a) providing said patient with a composite consisting of a N-isopropylacrylamide (NIPAAm) layer polymerized with a biodegradable layer containing gelatin and a layer of polypropylene (PP) non-woven, wherein a bone marrow derived mononuclear cell with CD45 negative and glycophorin A negative is cultivating on the biodegradable layer; (b) covering said composite on the skin defect of the patient; and (c) treating the composite with water below 25° C. to strip off the layer of polypropylene (PP) non-woven.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: December 9, 2014
    Assignee: Taipei Veterans General Hospital
    Inventors: Shih-Hwa Chiou, Cherng-Kang Perng, Han-Tzo Lin, Yi-Ping Yang
  • Publication number: 20140356454
    Abstract: An antibacterial wound dressing is based on or derived from gel-forming fibres such as carboxymethyl cellulose or alginate fibres having silver ions linked thereto at some but not all of the exchangeable sites such that the distribution of silver ions over the exchangeable sites is substantially uniform. The silvered fibres for the wound dressing can be prepared by contacting an assembly of precursor gel-forming fibres having exchangeable sites under conditions which do not cause irreversible gelling of the fibres with an amount of a solution containing silver ions so as to link silver ions at some but not all of the exchangeable sites, the whole of the assembly of precursor gel-forming fibres being contacted essentially simultaneously with the entire solution containing silver ions.
    Type: Application
    Filed: August 4, 2014
    Publication date: December 4, 2014
    Inventor: Roger Bray
  • Publication number: 20140356949
    Abstract: A carrier for expansion of induced pluripotent stem cells is provided, wherein the carrier comprises a substrate comprising one or more outer surfaces, wherein the one or more outer surfaces are modified with gas plasma treatment, and one or more structured indentations on one or more of the outer surfaces. The carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of making the carrier, and culturing induced pluripotent stem cells using the same carrier are also provided.
    Type: Application
    Filed: August 18, 2014
    Publication date: December 4, 2014
    Inventors: Brian Michael Davis, Kenneth Roger Conway, Evelina Roxana Loghin, Andrew Arthur Paul Burns, David Gilles Gascoyne, Scott Michael Miller
  • Publication number: 20140346073
    Abstract: A wound dressing includes a backing material, and thrombin, applied to the backing material. Preferably, the backing material includes biodegradable polyester, such as electrospun polycaprolactone. The thrombin preferably includes salmon thrombin adsorbed onto the backing material. A process of fabricating a wound dressing includes applying thrombin to the backing material. Preferably, the thrombin is prepared from the plasma of a salmonid. The thrombin is applied to the backing material by adsorbing the thrombin onto the backing material, preferably after applying a detergent solution to the backing material. The dressing can be lyophilized and vacuum-sealed within an air-tight wrapping.
    Type: Application
    Filed: July 8, 2014
    Publication date: November 27, 2014
    Applicant: SEA RUN HOLDINGS, INC.
    Inventors: Evelyn S. Sawyer, Paul A. Janmey
  • Publication number: 20140328885
    Abstract: Sheet for cutaneous application comprising a support layer made of loosely woven fabric embedded in a layer of silicone elastomer incorporating vitamin E or an ester thereof, wherein the layer of silicone elastomer has a thickness less than or equal to 2.0 mm and the silicone elastomer contains an elasticity modifier consisting of a triglyceride of saturated C8-C18 fatty acids.
    Type: Application
    Filed: May 24, 2013
    Publication date: November 6, 2014
    Applicant: IneSalus Corp.
    Inventor: Giorgio Panin
  • Publication number: 20140316324
    Abstract: A fluid absorbing pressure sensitive adhesive composition and adhesive articles including the fluid absorbing adhesive that have particular utility in the medical field, and in particular, for use with wound dressings is provided. The adhesive composition has superior fluid handling capacity, moisture vapor transmission and skin adhesion. Also described are dressings, cover drapes, and/or sealing components for negative pressure wound therapy applications. The articles include a thin film having a layer of a breathable hydrocolloid adhesive. When used in negative pressure wound therapy applications, the articles are breathable and fluid absorbing.
    Type: Application
    Filed: November 9, 2012
    Publication date: October 23, 2014
    Applicant: Avery Dennison Corporation
    Inventors: Anne Marie Wibaux, Vicky Van De Pol, Honorina Repriels
  • Publication number: 20140308325
    Abstract: The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.
    Type: Application
    Filed: February 19, 2014
    Publication date: October 16, 2014
    Inventors: Hans Christian Hedrich, Joris Hoefinghoff
  • Publication number: 20140308867
    Abstract: The present invention relates to woven or nonwoven fabric material having antimicrobial activity, and to its uses ranging from wound dressing, facial masks, surgical drapes and surgical clothing, to filter materials and similar applications where the antimicrobial effects are employed, as well as to a process for the preparation of the woven or nonwoven fabric material.
    Type: Application
    Filed: April 19, 2012
    Publication date: October 16, 2014
    Applicant: AR Metallizing N.V.
    Inventors: Paul Van Emmerick, Maura Roperto, Paula Gielen
  • Publication number: 20140303263
    Abstract: A method of producing a delivery device for delivering a chemical compound includes i) providing an interpenetrating polymer substrate (IP substrate) having a first continuous polymer comprising rubber and a second polymer having hydrogel or a hydrogelable precursor, where the second polymer is interpenetrating in the first polymer; ii) providing the chemical compound and a loading solvent for the chemical compound; and iii) loading the IP substrate with the chemical compound by subjecting the IP substrate to the loading solvent having the chemical compound under conditions where the loading solvent at least partially swells the second polymer. The chemical compound, the second polymer and the loading solvent are selected such that the work of adhesion (Whc) between the second polymer and the chemical compound during at least a part of the loading is at least about 0 J/m2.
    Type: Application
    Filed: November 23, 2012
    Publication date: October 9, 2014
    Inventors: Martin Alm, Søren Langer Steffensen