Flexible Web, Sheet, Film, Or Filament Base (e.g., Fabric, Bandage, Suture, Transdermal Patch, Orthopedic Cast Tape) Patents (Class 427/2.31)
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Publication number: 20140308867Abstract: The present invention relates to woven or nonwoven fabric material having antimicrobial activity, and to its uses ranging from wound dressing, facial masks, surgical drapes and surgical clothing, to filter materials and similar applications where the antimicrobial effects are employed, as well as to a process for the preparation of the woven or nonwoven fabric material.Type: ApplicationFiled: April 19, 2012Publication date: October 16, 2014Applicant: AR Metallizing N.V.Inventors: Paul Van Emmerick, Maura Roperto, Paula Gielen
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Publication number: 20140299796Abstract: A shielded head cover in accordance with an embodiment of the present application includes at least one attenuation portion including a radiation attenuating material configured and operable to protect a user head from radiation. The attenuation portion may include a varying amount of radiation attenuating material at different locations to provide for increased protection at desired locations. The attenuation portion may be embodied as a removable patch that is attached to the head cover. The attenuation portion may be provided by spraying particles of radiation attenuating material on the head cover. The attenuation portion may be embodied as a headband configured to be wrapped around a user's head and including attenuating material positioned in a pocket or cavity therein.Type: ApplicationFiled: May 13, 2014Publication date: October 9, 2014Inventor: Todd J. COHEN
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Publication number: 20140303263Abstract: A method of producing a delivery device for delivering a chemical compound includes i) providing an interpenetrating polymer substrate (IP substrate) having a first continuous polymer comprising rubber and a second polymer having hydrogel or a hydrogelable precursor, where the second polymer is interpenetrating in the first polymer; ii) providing the chemical compound and a loading solvent for the chemical compound; and iii) loading the IP substrate with the chemical compound by subjecting the IP substrate to the loading solvent having the chemical compound under conditions where the loading solvent at least partially swells the second polymer. The chemical compound, the second polymer and the loading solvent are selected such that the work of adhesion (Whc) between the second polymer and the chemical compound during at least a part of the loading is at least about 0 J/m2.Type: ApplicationFiled: November 23, 2012Publication date: October 9, 2014Inventors: Martin Alm, Søren Langer Steffensen
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Publication number: 20140271787Abstract: Disclosed herein is a soft, flexible, continuous, single-layer structural directional active delivery device such as a film product with discrete domains useful for controlled administration of the active to a patient. The discrete domains are substantially inseparable from one another, have different rates of dissolution and advantageously offer superior adhesion to the body of the patient while administering the active directionally and effectively.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: MONOSOL RX, LLCInventor: MONOSOL RX, LLC
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Publication number: 20140276479Abstract: Transdermal drug delivery systems comprising a drug-containing layer, a backing layer, and an occlusive overlay layer extending beyond the perimeter of the backing layer by 3 to 6 mm in all directions are described. The systems achieve increased drug delivery over an extended time period.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Noven Pharmaceuticals, Inc.Inventors: Viet Nguyen, Puchun Liu, Steven Dinh
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Publication number: 20140275864Abstract: The present invention is directed toward a wound dressing comprising a foam body made of polyurethane material treated with a plurality of colored biocidal dyes with at least one of the dyes being gram positive and at least one of the dyes being gram negative to dye the body a distinct color. The body has at least one planar surface and ranges from about 1 mm to about 10 mm in thickness and has an outer film cover and border with a hydrogel adhesive secured to the body. The foam body changes color when placed in contact with an infected wound site.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Inventor: Thomas J. Drury
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Publication number: 20140276478Abstract: Described are transdermal drug delivery systems for the transdermal administration of tertiary amine drugs, such as rivastigmine, fentanyl or rotigotine, comprising a polymer matrix comprising a free base form of the drug and at least one carboxyl group-containing compound. In some embodiments, the systems include a rate-controlling membrane and a skin-contacting face adhesive apart from the polymer matrix.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: NOVEN PHARMACEUTICALS, INC.Inventors: Jun Liao, Takito Shima, Puchun Liu, Steven Dinh
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Publication number: 20140276483Abstract: Described herein are transdermal compositions comprising methylphenidate in a polymer matrix comprising a non-reactive random acrylic polymer and an acrylic block copolymer. Method of making such compositions, and therapeutic methods using them also are disclosed.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Noven Pharmaceuticals, Inc.Inventors: Jun Liao, Puchun Liu, Steven Dinh
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Publication number: 20140276484Abstract: Clay composite sheets, mats, films or membranes without polymers. Methods of preparing clay composite sheets, mats, films or membranes without using polymers in the method. Methods of using clay composite sheets, mats, films or membranes prepared without using polymers. Antimicrobial dressing having organo-modified clay product. Transdermal delivery of drugs using organo-modified clay product and methods.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Materials Modification IncInventors: Kausik Mukhopadhyay, Krishnaswamy Kasthuri Rangan, Tirumalai Srinivas Sudarshan
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Publication number: 20140255595Abstract: An odor-absorbing foam composition comprising a cyclodextrin crosslinked with a polyurethane prepolymer. In one embodiment, the foam includes a ratio of the cyclodextrin to the polyurethane prepolymer selected to result in formation of the foam. The odor-absorbing foam may be used in a personal care product or wound care. A process for preparing a foam, including providing a cyclodextrin; providing a polyurethane prepolymer; combining the cyclodextrin with the polyurethane prepolymer; and allowing the polyurethane prepolymer to react with water and crosslink the cyclodextrin to form the foam. A process for preparing an odor-absorbing foam article such as a personal care product, including preparing the foam and applying it or the components thereof to a suitable substrate.Type: ApplicationFiled: April 24, 2014Publication date: September 11, 2014Applicant: Avery Dennison CorporationInventors: Anne Marie WIBAUX, Bert PAESEN
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Publication number: 20140248420Abstract: The present invention relates to method of preparing an absorbent wound care device comprising an active agent on a wound contacting surface, such as e.g. a protein or an enzyme, by the use of electrospraying, and a wound care device obtained by said method. The invention further relates to a wound care device comprising Thrombin and a polyurethane foam, and a method of treating bleeding.Type: ApplicationFiled: July 10, 2012Publication date: September 4, 2014Applicant: Coloplast A/SInventors: Hanne Everland, Kurt Osther, Jacob Vange, Lene Feldskov Nielsen
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Publication number: 20140248417Abstract: Biocompatible coatings and spin finishes that can be applied to polyhydroxyalkanoate (PHA) polymers, and medical devices made from PHA polymers, have been developed. The coatings impart good lubricity to PHA polymers, particularly to fibers and braids made from these materials, making the coatings ideal for use on medical devices such as PHA braided sutures. The spin finishes can be applied to PHA fibers to facilitate their manufacture, and also for their conversion to other products, including medical textiles. The spin finishes serve to protect multifilament fiber bundles, and keep them intact following extrusion, and also to impart lubricity to the fiber bundles and monofilament fibers so that they are not damaged in subsequent processing steps particularly in textile processing. The coating reduces tissue drag of, for example, braided sutures.Type: ApplicationFiled: May 15, 2014Publication date: September 4, 2014Applicant: Tepha, Inc.Inventors: David P. Martin, Said Rizk, Jon I. Montcrieff, Dennis W. Connelly
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Publication number: 20140242149Abstract: Provided in various embodiments are high viscosity, shear-thinning silicone compositions that can be pattern coated directly onto a substrate and silicone compositions having high-density particles suspended in an adhesive gel. The silicone compositions contain a thixotropic additive, such as a hydrogenated vegetable oil. The silicone compositions may be applied on a substrate for use in medical devices or wound dressings.Type: ApplicationFiled: October 12, 2012Publication date: August 28, 2014Applicant: Dow Corning CorporationInventors: David Gantner, Roger A. Gibas, Do-Lung Pan, Xavier Thomas, Christine A. Weber
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Publication number: 20140243727Abstract: Provided in various embodiments are high viscosity, shear-thinning silicone compositions that can be pattern coated directly onto a substrate. The silicone compositions may be prepared by mixing at least one organopolysiloxane, at least one SiH-containing organopolysiloxane, at least one emulsifying agent, a hydrosilyation catalyst and water. The silicone compositions may be applied on a substrate for use in medical devices or wound dressings.Type: ApplicationFiled: October 12, 2012Publication date: August 28, 2014Applicant: Dow Corning CorporationInventors: Roger A. Gibas, Yihan Liu, Do-Lung Pan, Jeffrey T. Rastello, Christine A. Weber
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Patent number: 8790699Abstract: Foam-formed collagen strands and methods for forming strands involve depositing a dispersed solution of an isolated cleaned, de-fatted, enzymatically-treated (or non-enzyme treated) human-derived collagen product having a preserved amount of its natural constituents into grooves of a grooved plate, and processing the dispersed collagen product to provide a foam-formed collagen strand. Foam-formed collagen strands may be processed into threads having a matrix of reticulated pores to conduct biological materials in and through the strand, the collagen of the collagen strand comprising isolated, enzymatically-treated human derived collagen having a preserved amount of its natural collagen constituents.Type: GrantFiled: April 23, 2010Date of Patent: July 29, 2014Assignee: Warsaw Orthpedic, Inc.Inventors: Nels Lauritzen, Lawrence A. Shimp, Brent Mitchell
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Publication number: 20140205741Abstract: A process for coating a personal care composition onto at least one discrete treatment area of a substrate having a first and second surface wherein the personal care composition has a yield point of from 10 Pa to 2000 Pa measured via a stress controlled amplitude sweep at a frequency of 1 Hz and a temperature of 25° C.Type: ApplicationFiled: January 24, 2014Publication date: July 24, 2014Applicant: The Procter & Gamble CompanyInventors: Clifford Theodore PAPSDORF, Brian Charles CRENSHAW
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Patent number: 8784928Abstract: Methods for the deposition of silver-comprising films on nonconducting substrates, and, more particularly, to deposition of such films that are very thin, are provided. The surface of nonconducting substrates is modified with a superabsorbent polymer to increase silver deposition when compared to a non-modified surface. Also provided are films produced using a swelling agent, whereby porosity of the surface of the nonconducting substrate is increased, thereby permitting increased silver deposition when compared to an unmodified surface.Type: GrantFiled: November 23, 2011Date of Patent: July 22, 2014Assignee: C. R. Bard, Inc.Inventors: Richard N. Terry, Fung Bor Chen, Zhihui Yin
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Publication number: 20140199468Abstract: A nanofiber is formed by combining one or more natural or synthetic polymeric materials and one or more than one cross-linking agents having at least two latent reactive activatable groups. The latent reactive activatable nanofiber may be used to modify the surface of a substrate by activating at least one of the latent reactive activatable groups to bond the nanofiber to the surface by the formation of a covalent bond between the surface of the substrate and the latent reactive activatable group. Some of the remaining latent reactive activatable group(s) are left accessible on the surface of the substrate, and may be used for further surface modification of the substrate. Biologically active materials may be immobilized on the nanofiber modified surface by reacting with the latent reactive groups that are accessible on the surface of the substrate.Type: ApplicationFiled: March 10, 2014Publication date: July 17, 2014Applicant: Innovative Surface Technologies, Inc.Inventors: Jie Wen, Patrick E. Guire
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Publication number: 20140194025Abstract: The present invention concerns stable aqueous protein dispersions comprising in an aqueous phase at least one self-assembling protein in dispersed form and also at least one specific dispersant for the self-assembling protein; processes for producing such stable aqueous dispersions; processes for electrospinning self-assembling proteins using such stable aqueous dispersions; processes for producing fibrous sheet bodies or fibers from such aqueous dispersions; the use of such aqueous dispersions for coating surfaces; the use of the materials produced by electrospinning in the manufacture of medical devices, hygiene articles and textiles; and also fibrous or fibrous sheet bodies produced by an electrospinning process of the present invention.Type: ApplicationFiled: February 3, 2014Publication date: July 10, 2014Applicants: Freudenberg Forschungsdienste KG, BASF SEInventors: Evgueni Klimov, Burghard Liebmann, Thomas Subkowski, Martin Möller, Doris Klee, Artem Davidenko, Wiebke Voigt, Gunter Scharfenberger
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Publication number: 20140186410Abstract: A dried adhesive coating is manufactured by steps of: a) providing a composition comprising a solution of a polymer, wherein at least 1 wt % of said polymer based on the molecular weight Mw are catechol groups, and wherein the concentration of said polymer in said composition is from 0.1 to 250 mg/ml, b) adjusting the pH of the composition to a value from about ó to about 7, either (i) before applying the composition to the surface to be coated or (ii) after applying the composition to the surface to be coated, c) applying the composition to the surface to be coated to obtain an adhesive coating on at least a part of the surface, and d) drying the coating.Type: ApplicationFiled: May 8, 2012Publication date: July 3, 2014Applicant: BIOPOLYMER PRODUCTS OF SWEDEN ABInventor: Camilla Fant
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Publication number: 20140186424Abstract: Multi-polymer compositions for the transdermal delivery of drugs, such as amine-functional drugs, in a flexible, finite form are described. The compositions comprise a polymer matrix that includes a drug or a pharmaceutically acceptable salt thereof and a polymer matrix comprising acrylic polymer(s), polyisobutylene polymer(s) and styrene-isoprene-styrene block copolymer(s). Methods of manufacturing and methods of using the compositions also are described.Type: ApplicationFiled: December 27, 2013Publication date: July 3, 2014Applicant: Noven Pharmaceuticals, Inc.Inventors: Joshua Kulakofsky, Puchun LlU
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Publication number: 20140188059Abstract: A system for treating a tissue site includes a pressure source to apply reduced pressure, and a manifold in fluid communication with the pressure source to provide reduced pressure to the tissue site. The system includes a drape for adhering to the tissue site to cover the tissue site and the manifold. The drape has a film layer having a thickness less than about 15 microns, and an adhesive coupled to the film layer. The adhesive seals the film layer to the tissue site to create a sealed space having the manifold therein. The adhesive is sufficiently thick to limit leaks between the film layer and the tissue site.Type: ApplicationFiled: November 14, 2013Publication date: July 3, 2014Applicant: KCI Licensing, Inc.Inventors: Timothy Mark Robinson, Christopher Brian Locke
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Publication number: 20140186517Abstract: A process is described herein for applying antimicrobials to substrates such as fabrics. An antimicrobial-binder mixture is provided that includes an antimicrobial and a binder that includes guar gum in an aqueous solution, which is applied to the substrate. Once the substrate is cured, spikes formed by the antimicrobial are disposed on the fabric and function to rupture membranes of infectious agents.Type: ApplicationFiled: March 5, 2014Publication date: July 3, 2014Inventor: Joseph Giovanniello
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Publication number: 20140186428Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: a step A of obtaining an adhesive agent layer composition comprising oxybutynin hydrochloride as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, a sterol, an organic acid, and a tackifier; a step B of heating the adhesive agent layer composition at a temperature in a range from 55 to 70° C. for 1 to 24 hours; and a step C of cooling the heated adhesive agent layer composition to a temperature lower than room temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.Type: ApplicationFiled: June 21, 2013Publication date: July 3, 2014Inventors: Kazunosuke AIDA, Terumitsu KAIHO, Tetsurou TATEISHI, Nobuo TSUTSUMI
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Publication number: 20140178446Abstract: This invention relates to deployable hemostatic materials comprising chitosan fibers. The hemostatic materials are suitable for use in sealing or controlling active bleeding from artery and vein lacerations and punctures, and for controlling oozing from tissue.Type: ApplicationFiled: February 28, 2014Publication date: June 26, 2014Applicant: Loma Linda University Medical CenterInventors: Yong Hua Zhu, Chang Zheng Yang, Wolff M. Kirsch
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Publication number: 20140178564Abstract: A medical dressing containing an antimicrobial agent is disclosed. The medical dressing comprises a layered fabric comprising an inner layer of substantially hydrophilic material, an outer layer of substantially hydrophobic material on both sides of the inner layer; and an antimicrobial agent. The antimicrobial agent may be releasably impregnated into the fabric, coated on said fabric or a combination thereof. The antimicrobial agent may be a biguanide, such as polyhexamethylene biguanide (PHMB). The fabric inner layer material may be substantially a cellulose fiber, preferably substantially rayon, and the fabric outer layer material may be substantially polyester, e.g., a combination of textile matrix grade polyester fiber and amorphous binder grade polyester fiber. The fabric is preferably treated with an aqueous solution of surfactant and PHMB to have about 1500-3500 ppm of extractable PHMB.Type: ApplicationFiled: February 28, 2014Publication date: June 26, 2014Applicant: Covidien LPInventor: Harish A. Patel
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Patent number: 8759454Abstract: A polymer blend is provided that includes a polycarbonate polyurethane polymer component having a water contact angle greater than 75 degrees and a polyurethane polymer component having a water contact angle less than 75 degrees. The polycarbonate polyurethane component and the other polyurethane polymer can be immiscible with respect to one another, and thus are phase separated in the polymer blend. The weight percentage of the polycarbonate polyurethane polymer component is greater than the weight percentage of the other polyurethane polymer component in the blend. The polymer blend is well suited for realizing a low friction surface of a variety of medical and non-medical devices.Type: GrantFiled: April 16, 2013Date of Patent: June 24, 2014Assignee: Innovia LLCInventors: Yongmoon M. Kwon, Leonard Pinchuk
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Publication number: 20140170088Abstract: The present disclosure provides nanoparticles of barium zirconium oxide (BaZrO3.BaCO3) and a process for preparation thereof. The present disclosure further provides a coating formulation that chiefly comprises the BaZrO3.BaCO3 nanoparticles along with its method of preparation. Still further, the present disclosure provides X-ray retardant articles and an X-ray retardant preparation for topical application.Type: ApplicationFiled: December 16, 2013Publication date: June 19, 2014Applicants: SECRETARY, DEPARTMENT OF ELECTRONICS AND INFORMATION TECHNOLOGY (DeitY), CENTRE FOR MATERIALS FOR ELECTRONICS TECHNOLOGY (C-MET)Inventors: Bharat Bhanudas Kale, Milind Vyankatesh Kulkarni, Rajendra Popat Panmand, Ujjwala Vilas Kawade, Sanjay Krushnaji Apte, Sonali Deepak Naik, Jalindar Dnyandev Ambekar, Ravindra Shravan Sonawane, Ramadoss Marimuthu, Dinesh Pundalik Amalnerkar, Nilofer Shroff, Sandip Chatterjee
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Publication number: 20140170208Abstract: A method for preparing a transdermal patch comprising a substrate layer is provided, the method comprising the steps of contacting an active pharmaceutical ingredient with a retaining means to provide a composition, applying the composition obtained in step (a) to a carrier material to form a substrate layer of the transdermal patch, wherein the retaining means remain within the final transdermal patch.Type: ApplicationFiled: February 21, 2014Publication date: June 19, 2014Applicant: LABTEC GMBHInventors: Sebastian BRAUN, Armin BREITENBACH, Ulrich BECKER
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Publication number: 20140170196Abstract: The present invention provides disposable cloths that are designed to reduce itching discomfort when wiped across the vulvar tissue. These disposable cloths are wetted with a composition that includes at least one anesthetic, protectant, buffer, and surfactant. The composition is substantially clear and preferably does not bring about a cooling or stinging sensation when applied to the vulvar tissue. Furthermore, the composition has a pH adapted to vulvar use.Type: ApplicationFiled: December 19, 2012Publication date: June 19, 2014Inventors: Bobby Corry, Russ Hovda, Michael L. Caswell
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Publication number: 20140171886Abstract: A patch for treatment of eyelid diseases that is provided with a support, a pressure-sensitive adhesive layer, and a release layer in this order, wherein (a) the pressure-sensitive adhesive layer includes the following (a-1) to (a-4): (a-1) a styrene-isoprene-styrene block copolymer, a tackifier resin, and a softening agent are contained; (a-2) a ratio (mass ratio) of the styrene-isoprene-styrene block copolymer and the tackifier resin is 1:2 to 1:4; (a-3) a content of the softening agent is 40% to 60% by mass; and (a-4) further 0.005% to 5% by mass of clobetasol or acid ester thereof is contained; and (b) the support has elastic modulus with a Young's modulus of 0.01 to 0.5 GPa: and a method for producing the patch for treatment of eyelid diseases including: forming a pressure-sensitive adhesive layer on a upper surface of a release layer.Type: ApplicationFiled: December 19, 2012Publication date: June 19, 2014Applicant: SENJU USA, INC.Inventors: Takahiro Ogawa, Akiharu Isowaki, Koji Kawahara, Takao Hiraoka, Mariko Tanaka, Chihiro Kenmochi
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Publication number: 20140161865Abstract: A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.Type: ApplicationFiled: February 21, 2013Publication date: June 12, 2014Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Naruhito Higo, Tetsurou Tateishi, Takaaki Terahara, Kazunosuke Aida, Shigeki Hayashi, Nobuo Tsutsumi
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Publication number: 20140155791Abstract: A medical drape for use with a reduced pressure system for providing reduced pressure to a tissue site is described. In some embodiments, the drape may include a flexible film, and an adhesive layer coupled to the flexible film. The adhesive layer may include a first adhesive disposed on a first portion of the flexible film in a first pattern. The first adhesive can be configured to secure the flexible film proximate to the tissue site. The adhesive layer generally includes a second adhesive disposed on a second portion of the flexible film in a second pattern. The second adhesive can be configured to seal the flexible film proximate to the tissue site. The first pattern and the second pattern are preferably registered so that the first portion and the second portion are offset to cover substantially different portions of the flexible film.Type: ApplicationFiled: November 14, 2013Publication date: June 5, 2014Applicant: KCI Licensing, Inc.Inventors: Timothy Mark Robinson, Christopher Brian Locke
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Patent number: 8715770Abstract: A device for coating dry powder microparticles onto a surface may include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.Type: GrantFiled: March 9, 2011Date of Patent: May 6, 2014Assignee: STC.UNMInventors: Parthiban Selvam, Hugh D. C. Smyth, Martin Donovan
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Publication number: 20140121619Abstract: The present invention relates to coatings for articles comprising a non-zeolitic silica mesoporous structure. The coatings of the present invention have shown an ability to effectively reduce odors.Type: ApplicationFiled: October 25, 2012Publication date: May 1, 2014Applicant: Dow Global Technologies LLCInventors: Evren Aslan-Guerel, Gert J. Claasen, Rudolf J. Koopmans, Scott T. Matteucci
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Publication number: 20140120145Abstract: A process is described herein for applying antimicrobials to substrates such as fabrics. An antimicrobial-binder mixture is provided that includes an antimicrobial and a binder that includes guar gum in an aqueous solution, which is applied to the substrate. Once the substrate is cured, spikes formed by the antimicrobial are disposed on the fabric and function to rupture membranes of infectious agents.Type: ApplicationFiled: October 26, 2012Publication date: May 1, 2014Inventor: Joseph Giovanniello
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Publication number: 20140113061Abstract: A wound dressing and a method of making the wound dressing is described herein. The wound dressing is formed of an absorbent substrate formed of one or more layers and a low-adherence layer disposed on the substrate. The low-adherence layer can be disposed within at least a portion of the substrate. The low-adherence layer is formed of a mixture of at least one highly fluorinated polymer and at least one acidic polymer. The at least one highly fluorinated polymer has a fluorine content greater than the fluorine content of the at least one acidic polymer.Type: ApplicationFiled: November 15, 2012Publication date: April 24, 2014Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Robert D. Allen, Christopher E. Bannister, Jere J. Brophy, Richard A. DiPietro
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Patent number: 8703634Abstract: Hemostatic compositions comprising a wet layered clay (e.g., wet kaolin) and, optionally, a zeolite, as well as devices and methods of use to promote blood clotting, are provided.Type: GrantFiled: February 13, 2008Date of Patent: April 22, 2014Assignee: The Regents of the University of CaliforniaInventors: Sarah Baker, April Sawvel, Galen D. Stucky
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Patent number: 8685437Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.Type: GrantFiled: March 26, 2009Date of Patent: April 1, 2014Assignee: MonoSol Rx, LLCInventors: Robert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz
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Patent number: 8668703Abstract: Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is a urethral, ureteral, or nephroureteral catheter or stent. In some embodiments, the device is an absorbable esophageal or tracheal stent. Wound closure devices are also provided herein, including a substrate and a collagen inhibitor on or in the substrate. Also provided are surgical packings, including a substrate and a collagen inhibitor on or in the substrate. A barrier material for preventing adhesions in a subject is further provided, including a preformed or in situ formable barrier substrate and a collagen inhibitor on or in the substrate. Kits comprising the coated substrates are also provided.Type: GrantFiled: November 30, 2007Date of Patent: March 11, 2014Assignee: Wake Forest University Health SciencesInventors: Christopher A. Sullivan, Steve J. Hodges, Anthony Atala, James J. Yoo
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Publication number: 20140046236Abstract: The present invention relates to a layered chitosan scaffold wherein said layered scaffold comprises at least two fused layers, wherein at least one of the fused layers comprises a chitosan nanofiber membrane and the other fused layer comprises a porous chitosan support layer. Moreover, the present invention provides a layered chitosan scaffold characterized by (i) a good adhesion between the porous and nanofiber layers, (ii) a tuneable porosity of the nanofiber layer by tuning the distance between the nanofibers, (iii) a stable nanofibers and porous morphology even when immersed in water or other solvents and a process for the preparation of such layered chitosan scaffold. The present invention also provides a process for the preparation of the layered chitosan scaffold.Type: ApplicationFiled: May 24, 2011Publication date: February 13, 2014Applicant: UNIVERSITY OF LIEGEInventors: Patrice Filée, Astrid Freichels, Christine Jéröme, Abdelhafid Aquil, Alain Colige, Victor Tchemtchoua Tateu
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Patent number: 8647699Abstract: The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.Type: GrantFiled: February 23, 2012Date of Patent: February 11, 2014Assignee: Novartis AGInventors: Achim Müller, Monika Knuth, Ralf Pasternack, Jens Zotzel, Christine Reiff
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Patent number: 8636753Abstract: The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use.Type: GrantFiled: February 8, 2007Date of Patent: January 28, 2014Assignee: TYRX, Inc.Inventors: Fatima Buevich, Frank Do, William McJames, Satish Pulapura, William Edelman, Arikha Moses, Mason Diamond, Shari Timothy
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Patent number: 8637072Abstract: The present invention relates to wound dressings, in particular to an antibacterial wound dressing based on silvered gel-forming fabric and to a process for the manufacture of such a wound dressing.Type: GrantFiled: March 18, 2009Date of Patent: January 28, 2014Assignee: Convatec Technologies, Inc.Inventors: David Kershaw, Barry DeBoorder, Stephen John Law
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Patent number: 8632840Abstract: A method of making a compression device having a pressure applicator for applying a compression to a wearer's body part when the device is placed on the wearer's body includes applying a colorant having a first color to at least a portion of a loop material having a second color that is different than the first color. The step of applying colorant includes applying colorant to loops of the loop material so that repeated connection and disconnection of hook material attached to the device with the loop material causes loops having the first color of the colorant thereon to break so that the second color of the loop material is revealed by breakage of loops of the loop material having the colorant applied thereto.Type: GrantFiled: January 31, 2012Date of Patent: January 21, 2014Assignee: Covidien LPInventor: Raymond C. Avitable
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Patent number: 8632839Abstract: The present disclosure relates to self-supporting films for delivery of a therapeutic agent containing at least one hydrophobic polymer and at least one therapeutic agent. Methods of forming the self-supporting films are also disclosed.Type: GrantFiled: September 22, 2011Date of Patent: January 21, 2014Assignee: Covidien LPInventors: Joshua Stopek, Garrett Ebersole, Amin Elachchabi, Daniel Broom
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Publication number: 20140018716Abstract: A method (400) of manufacturing a wound dressing is disclosed that includes obtaining alginate fibers (108) and the step (404) of spraying either the alginate fibers (108) or a dressing or dressing layer (610) of the alginate fibers with an aqueous solution (801) comprising a polysaccharide, which can be carboxymethylcellulose. The step of spraying can occur while the alginate fibers, dressing, or dressing layer are wet. A step (405) of flash drying can follow to remove the solute of the aqueous solution to leave the polysaccharide along the alginate. The step of spraying can be selective, such that only portions of the dressing layer include the polysaccharide.Type: ApplicationFiled: July 16, 2012Publication date: January 16, 2014Inventor: Debashish Chakravarthy
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Publication number: 20140018717Abstract: A wound dressing for mass casualty burn injury events is provided that is capable of being stockpiled for long periods of time without special storage conditions, may be applied by persons with little or no training, immediately restores skin barrier function and reduces pain, manages wound exudate, accommodates edema, and is transparent. The dressing does not integrate into the wound while simultaneously providing antimicrobial activity, thereby avoiding complication of the wound condition when proper medical attention is delayed for significant periods of time.Type: ApplicationFiled: July 9, 2013Publication date: January 16, 2014Inventor: Mark E. Dillon
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Publication number: 20140011893Abstract: A method of preparing a mucoadhesive film formulation by preparing a film forming composition including lambda carrageenan as a film forming polymer, at a concentration of about 1-7% by weight, a plasticizer at a concentration of about 1-15% by weight, a biologically active substance, and purified water; distributing the film forming composition as a wet film layer onto a solid surface; and allowing the film layer to dry. A mucoadhesive film obtained by the method and a film dosage unit.Type: ApplicationFiled: March 21, 2012Publication date: January 9, 2014Inventor: Kjell Stenberg
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Publication number: 20140010949Abstract: Coatings for medical devices, methods of making the coatings, and methods of using them are described.Type: ApplicationFiled: July 16, 2013Publication date: January 9, 2014Inventors: Keith M. Faucher, Hui Tang, Lisa Rogers, Joseph Ferraro, Paul Martakos, Steven A. Herweck, Theodore Karwoski