Flexible Web, Sheet, Film, Or Filament Base (e.g., Fabric, Bandage, Suture, Transdermal Patch, Orthopedic Cast Tape) Patents (Class 427/2.31)
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Publication number: 20130052236Abstract: The present disclosure provides a medical assembly comprising a surgical barrier aspect comprising polylactic acid, and a hydrophilic mucoadhesive aspect, wherein the surgical barrier aspect is provided on a first side of the assembly and the mucoadhesive aspect is provided on a second side of the assembly. The disclosure also relates to a medical assembly comprising a surgical barrier aspect, a short term mucoadhesive aspect, an intermediate term protein polymerization adhesive aspect, and a long term tissue ingrowth implant localization aspect. The aforementioned medical assemblies may be provided as layered sheet structures. Also provided are methods for preparing a medical assembly.Type: ApplicationFiled: August 29, 2012Publication date: February 28, 2013Applicant: MAST BIOSURGERYInventors: Joerg Tessmar, Eva Esser, Lukas Bluecher, Michael Milbocker
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Publication number: 20130053806Abstract: A composite material for use in a medical device, such as a dressing, has an absorbent foam layer and a textile support layer having openings. A silicone-based gel impregnates the textile support without filling the openings in the support. The composite material is made by coating a textile structure with a silicone pre-polymer solution, depositing a polyurethane-based absorbent on one face of the coated textile structure and polymerizing the prepolymer solution.Type: ApplicationFiled: July 3, 2012Publication date: February 28, 2013Applicant: ZODIAC AUTOMOTIVE DIVISIONInventors: Jean-Roger Guillo, Sophie Roland, Vincent Chartron
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Publication number: 20130053748Abstract: A non-adherent wound dressing (1) comprises a substrate (2) in the form of a perforated sheet of melt-blown non-woven material. The substrate (2) is impregnated with, and coated on both sides with, a silicone gel (3).Type: ApplicationFiled: August 24, 2012Publication date: February 28, 2013Applicant: BRIGHTWAKE LIMITEDInventor: Stephen COTTON
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Publication number: 20130052248Abstract: An item of clothing (10) for daily pharmacological treatment of a fungal infection, comprising: a textile material (20) to manage moisture when the item of clothing (10) is worn; microcapsules (30) grafted on the textile material (20); and antifungal agents encapsulated within the microcapsules (30) to pharmacologically treat the fungal infection when released from the microcapsules (30).Type: ApplicationFiled: August 26, 2011Publication date: February 28, 2013Inventors: Marcus Chun Wah YUEN, Joanne Yiu Wan YIP, Kevin CHEUK, Chi Wai KAN, Shuk Yan CHENG
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Patent number: 8383188Abstract: A high strength surgical suture material with improved tie down characteristics and tissue compliance formed of ultrahigh molecular weight polyethylene (UHMWPE) yarns, the suture being coated with arginine-glycine-aspartate (RGD) peptide. The suture has exceptional strength, is ideally suited for most orthopedic procedures, and can be attached to a suture anchor or a curved needle.Type: GrantFiled: July 19, 2011Date of Patent: February 26, 2013Assignee: University of ConnecticutInventors: Augustus D. Mazzocca, Mary Beth McCarthy
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Publication number: 20130045266Abstract: A new polymeric material for biological tissue regeneration or treatment with a drug delivery system which contains therapeutic agents and/or bioactive molecules to reduce infection and inflammatory reaction at a wound site and maximize tissue regeneration and wound healing is provided. The new bioactive molecule-loaded polymeric material is prepared by (1) preparing micrometer or nanometer sized bioactive molecule-loaded particles; (2) modifying the surface of the prepared particles and immobilizing the particles on the surface of the polymeric material; and (3) physically treating the surface of the polymeric material to improve binding strength of the particles immobilized thereon.Type: ApplicationFiled: August 15, 2012Publication date: February 21, 2013Applicants: CHUNGBUK NATIONAL UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION, INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY, KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Seok Hwa CHOI, Jun Sik SON, Kyu-Bok LEE, Seong Soo KANG
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Publication number: 20130042482Abstract: A skin engaging member suitable for use in a hair removal device, said skin engaging member comprising an anti-irritation agent.Type: ApplicationFiled: August 15, 2012Publication date: February 21, 2013Inventors: Valerie Jean Bradford, Michael Joseph Kwiecien, Timothy Woodrow Coffindaffer, Karen Marie Lammers, Edward Dewey Smith, III, Jason Edward Cook, Brian Joseph Limberg
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Patent number: 8377499Abstract: A method of forming a coating on a medical device having a controlled morphology is described.Type: GrantFiled: February 28, 2011Date of Patent: February 19, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Lothar Walter Kleiner, Jessica Renee DesNoyer, Stephen Dirk Pacetti, Syed Faiyaz Ahmed Hossainy, O. Mikael Trollsas, Michael Huy Ngo
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Patent number: 8377107Abstract: A method of forming a coating on a medical device having a controlled morphology is described. A medical device having a controlled morphology is described.Type: GrantFiled: February 28, 2011Date of Patent: February 19, 2013Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Lothar Walter Kleiner, Jessica Renee DesNoyer, Stephen Dirk Pacetti, Syed Faiyaz Ahmed Hossainy
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Publication number: 20130041330Abstract: The present invention provides a micro-needle device that includes a substrate, a micro-needle provided on the substrate, and a physiologically active composition deposited on the micro-needle and/or the substrate. In the micro-needle device, the physiologically active composition contains: at least one polyhydric alcohol selected from glycerin, ethylene glycol, propylene glycol and 1,3-butylene glycol; and a physiologically active substance, and contains substantially no water.Type: ApplicationFiled: February 24, 2011Publication date: February 14, 2013Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Toshiyuki Matsudo, Shinpei Nishimura, Seiji Tokumoto, Kumi Morimoto
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Patent number: 8372806Abstract: The transdermal delivery system for treating infertility in a patient comprises an apparatus (10) for facilitating transdermal delivery of a drug (5a) through an area of the apparatus (10) comprises an ablator that is configured to generate a microporation in the area of the skin of the patient, and comprises a drug (5a), wherein the drug effects at least one of the biological regulation of at least one oocyte containing follicle, stimulation of follicle growth, induction of ovulation, promotion of gestational status, maintenance of conceptus, maintenance of pregnancy.Type: GrantFiled: October 6, 2006Date of Patent: February 12, 2013Assignee: Pantec Biosolutions AGInventors: Christof Böhler, Thomas Bragagna, Reinhard Braun, Werner Braun, Herbert Zech
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Patent number: 8367158Abstract: The method forms a liquid-repellent film on a surface of a nozzle plate having nozzle apertures through which droplets of liquid are ejected. The method includes: a termination process step of carrying out a hydrogen termination process or a halogen termination process on a surface of a nozzle plate, at least a portion of the surface of the nozzle plate being made of a material containing silicon; and a liquid-repellent film formation step of forming a liquid-repellent film on the surface of the nozzle plate after the termination process step by bringing a liquid-repellent film raw material into contact with the surface of the nozzle plate while applying energy to the surface. Each molecule constituting the liquid-repellent film raw material has an unsaturated carbon bond at an end and has a liquid-repellent functional group. The liquid-repellent film is bonded to the surface of the nozzle plate through silicon-carbon bonds.Type: GrantFiled: September 24, 2010Date of Patent: February 5, 2013Assignee: FUJIFILM CorporationInventor: Hiroki Uchiyama
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Publication number: 20130029030Abstract: The present invention relates to a matrix material comprising a pharmaceutical composition such as a matrix material with a pharmaceutical composition applied by ultrasonic spray technology on the surface. In one embodiment the pharmaceutical composition comprises thromb in. The invention further describes a method for making the matrix material which has a pharmaceutical composition coated onto the surface of the matrix material using ultrasonic spray technology. In one specific embodiment the invention also relates to the use of said matrix material for promotion of hemostasis and/or wound healing. The invention also relates to a kit-of-parts comprising a matrix with a pharmaceutical composition and a container with a peelable lid.Type: ApplicationFiled: March 14, 2011Publication date: January 31, 2013Inventor: Kristian Larsen
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Publication number: 20130028954Abstract: The present invention relates to a hemostatic dressing which comprises a plurality of layers that contain resorbable materials and/or coagulation proteins. In particular, the invention includes dressings in which a layer of thrombin is sandwiched between a first and second layer of fibrinogen and wherein the layer of thrombin is not coextensive with the first and/or second layer of fibrinogen. The hemostatic dressings are useful for the treatment of wounded tissue.Type: ApplicationFiled: September 28, 2012Publication date: January 31, 2013Inventors: Martin J. MacPhee, Dawson Beall, Stanley Friedman
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Patent number: 8361538Abstract: Devices and methods for applying a coating to an implantable device are disclosed. A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to an ultrasonic material delivery apparatus. The ultrasonic material delivery apparatus includes an ultrasonic generator. At least one of the ultrasonic material delivery apparatus and the implantable device has a positive or negative electric charge. An application material is applied to the implantable device using the ultrasonic material delivery apparatus.Type: GrantFiled: December 9, 2008Date of Patent: January 29, 2013Assignee: Abbott LaboratoriesInventor: Stephen Pacetti
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Publication number: 20130022734Abstract: In the method for producing a medical pressure-sensitive adhesive tape or sheet of the invention, a water dispersion-type copolymer solution having a specific composition is used. Therefore, the problem caused by high thixotropy can be eliminated and a pressure-sensitive adhesive layer can be relatively easily formed on a porous substrate by a direct method. In addition, when the medical pressure-sensitive adhesive tape or sheet obtained by the method of the invention is attached to the skin surface, skin adhesion and tube fixing are excellent and at the same time, irritation to skin is low.Type: ApplicationFiled: July 20, 2012Publication date: January 24, 2013Applicant: NITTO DENKO CORPORATIONInventors: Tatsuya MURATA, Noriyuki KIKUTA, Atsushi HAMADA, Tomonari NAITO, Nobuaki MARUOKA
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Patent number: 8359106Abstract: Adhesiveless direct bonding between polymeric tubular members assembled with an interference fit using an oxidative cold gas plasma treatment, and implantable medical leads manufactured in part using a cold gas plasma bonding process are disclosed. An illustrative method includes subjecting a number of polymeric tubular members to an oxidative cold gas plasma, creating an oxygen rich layer on each of the tubular members. The treated surfaces of the tubular members are assembled together, forming a direct bond along an overlapping region between the tubular members when in conformal contact with each other.Type: GrantFiled: September 10, 2009Date of Patent: January 22, 2013Assignee: Cardiac Pacemakers, Inc.Inventors: Kalpana Viswanathan, Paul E. Zarembo
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Publication number: 20130011491Abstract: This invention pertains to method for imparting a durable antimicrobial activity to substrates, particularly textiles. An acetate-free metal and peroxide antimicrobial treatment formulation is prepared by adjusting the pH of a mixture of a metal salt in aqueous hydrogen peroxide to about 7.5. The substrate is treated with the composition and dried to afford the treated substrate with antimicrobial activity. Zinc salts, ions, or complexes are preferred.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Applicant: QUICK-MED TECHNOLOGIES, INC.Inventors: William Toreki, Albina Mikhaylova, Susan Leander, Bernd Liesenfeld, Gerald M. Olderman
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Publication number: 20120330209Abstract: The present application discloses preparations of antimicrobial wound dressings. Strongly binding polymeric dialkyl aminoalkyl(meth)acrylates are used to treat highly absorbent wound dressing materials. The resulting finish is highly antimicrobial effective and non-leachable.Type: ApplicationFiled: June 20, 2012Publication date: December 27, 2012Inventors: Zhiqiang Song, Ted Deisenroth
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Publication number: 20120321686Abstract: The present invention relates to antifungal materials, particularly to nanoparticles comprising or consisting of a non-persistent inorganic support material such as Tricalciumphosphate (TCP) and copper as a dopant in the form of Cu+/?0, Cu+1 and or Cu+2; to composite materials or liquid formulations containing such nanoparticles. Further, the invention relates to the manufacture of such nanoparticles, composites, liquid formulations and to the use of such nanoparticles, composites, liquid formulations as an antifungal component.Type: ApplicationFiled: December 24, 2009Publication date: December 20, 2012Applicants: ETH Zurich, PERLEN CONVERTING AGInventors: Stefan Bokorny, Tobias Maienfisch, Stefan Loher, Wendelin J. Stark
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Patent number: 8333743Abstract: This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial effect.Type: GrantFiled: May 3, 2010Date of Patent: December 18, 2012Assignees: Quick-Med Technologies, Inc., University of Florida Research Foundation, Inc.Inventors: William Toreki, Gerald Olderman, Gregory Schultz, Christopher Batich
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Publication number: 20120316518Abstract: The invention relates to a device for the negative pressure treatment of wounds comprising (a) a covering material for providing a wound space with an air-tight seal; (b) optionally means for connecting a negative pressure source; and (c) a wound dressing containing (c1) a nonwoven material which is wetted with (c2) an ointment base, and also a method for producing a corresponding wound dressing. In addition, the invention relates to the use of an nonwoven material, which is wetted with an ointment base, for application as a wound dressing in the negative pressure treatment of wounds.Type: ApplicationFiled: June 8, 2012Publication date: December 13, 2012Inventors: Pierre Croizat, Axel Eckstein
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Publication number: 20120303057Abstract: This invention relates to a suture including a drug-loaded polymer layer and a method of manufacturing the same, and more particularly, to a suture, the surface of which is wound with a film including a drug-loaded biodegradable polymer layer, or coated with a drug-loaded biodegradable polymer layer, and to a method of manufacturing the same.Type: ApplicationFiled: November 25, 2011Publication date: November 29, 2012Inventors: Young Bin Choy, Chan Yeong Heo, Ji Eun Lee, Su Bin Park
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Patent number: 8309222Abstract: The present disclosure describes a coating for a surgical filament including a vinyl lactam polymer and a lactone polymer.Type: GrantFiled: April 25, 2007Date of Patent: November 13, 2012Assignee: Covidien LPInventors: Joshua Stopek, Brian Cuevas, Joseph Hotter
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Publication number: 20120282308Abstract: A film containing alginate membrane and a manufacturing method of the same are revealed. A film carrier is used to absorb liquid and is treated by two separate and continuous coating processes. At least one surface of the film carrier is coated with a layer of alginate solution containing a certain percent of sodium alginate or potassium alginate by weight and then is coated with a layer of salt water solution containing a certain percent of divalent metal ions. Then crosslinking occurs between the alginate in the alginate solution and the divalent metal ions in the salt solution on the surface of the film carrier or infiltrating into the film carrier so as to form a hydrogel complex membrane having a network structure. Thus the continuous and fast mass-production of the film is achieved.Type: ApplicationFiled: September 22, 2011Publication date: November 8, 2012Inventors: Yao-Chung CHIU, Yu-Yueh Lin
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Publication number: 20120282305Abstract: Biological surfactants connected to surfaces of silicone-based materials are provided. Compositions of electrolytes and a biological surfactant are also provided. Methods for increasing the surface wettability of a silicone-based material by contacting the silicone-based material with a biological surfactant, methods for increasing evaporation from a silicone-based material by contacting a surface of the silicone-based material with a biological surfactant, methods for increasing levels of interleukin-8 during inflammation by contacting a cell with a biological surfactant, and methods for decreasing expression of a biological surfactant by contacting a cell with an siRNA are further provided.Type: ApplicationFiled: January 7, 2011Publication date: November 8, 2012Applicant: The Research Foundation of State University of New YorkInventors: Xiaolan Lin, Miriam Rafailovich
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Patent number: 8304595Abstract: Methods, systems, and apparatuses for nanomaterial-enhanced hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. The hemostatic materials and structures may incorporate nanostructures and/or further hemostatic elements such as polymers and/or glass beads. The hemostatic materials and structures may be resorbable. Example embodiments include hemostatic bandages, hemostatic plugs, and hemostatic formulations.Type: GrantFiled: December 5, 2008Date of Patent: November 6, 2012Assignee: Nanosys, Inc.Inventors: R. Hugh Daniels, Robert S. Dubrow, Robert Enzerink, Esther Li, Vijendra Sahi, Jay L. Goldman, J. Wallace Parce
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Publication number: 20120277772Abstract: The invention relates to a treated HPPE yarn characterized in that the treated HPPE yarn comprises: a porous polyolefin layer that adheres to a surface of a HPPE yarn and covers at least partly the surface of the HPPE yarn; a composition comprising an active agent and which composition is at least partially absorbed within the porous polyolefin layer. The invention further relates to an article comprising the treated HPPE yarn, a device comprising the treated HPPE yarn or the article. The invention also relates to a process for preparing the treated HPPE yarn or treated HPPE yarn structure or treated HPPE yarn configuration and use of the treated HPPE yarn or an article or a device comprising the treated HPPE yarn for automotive applications, marine applications, aerospace applications, medical applications, defense applications, sports/recreational applications, architectural applications, clothing applications, bottling applications, machinery applications.Type: ApplicationFiled: August 5, 2010Publication date: November 1, 2012Applicant: DSM IP ASSETS B.V.Inventors: Gerardus Aben, Edith Elizabeth Van Den Bosch, Claudia Maria Vaz
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Publication number: 20120277719Abstract: The present disclosure provides, am ng other things, a coated device comprising: a porous substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a first layer and a second layer adjacent to the first layer, wherein the first layer comprises a first polymeric material and at least first interacting moiety, wherein the second layer comprises a second polymeric material and at least second interacting moiety, and wherein the interacting moieties on adjacent layers interact with one another so that the adjacent layers are associated with each other into the film; and an agent for delivery associated with the coated device, such that decomposition of one or more layers of the film results in release of the agent.Type: ApplicationFiled: April 27, 2012Publication date: November 1, 2012Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Anita Shukla, Paula T. Hammond
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Patent number: 8298565Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto the substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming the coating; and sintering the coating under conditions that do not substantially modify the morphology of the pharmaceutical agent.Type: GrantFiled: July 14, 2006Date of Patent: October 30, 2012Assignee: Micell Technologies, Inc.Inventors: Doug Taylor, Jim McClain, Clint Smoke, Mike Cole, James DeYoung
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Publication number: 20120265158Abstract: A method for preparing a transdermal patch comprising a substrate layer is provided, the method comprising the steps of contacting an active pharmaceutical ingredient with a retaining means to provide a composition, applying the composition obtained in step (a) to a carrier material to form a substrate layer of the transdermal patch, wherein the retaining means remain within the final transdermal patch.Type: ApplicationFiled: September 9, 2010Publication date: October 18, 2012Applicant: LABTEC GMBHInventors: Sebastian Braun, Armin Breitenbach, Ulrich Becker
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Publication number: 20120259360Abstract: A high strength surgical suture formed of ultrahigh molecular weight polyethylene (UHMWPE) yarns, the suture being coated with native or denatured collagen. The braided jacket surrounds a core formed of twisted yarns of ultrahigh molecular weight polyethylene. The suture has exceptional strength, is ideally suited for most orthopedic procedures, and can be attached to a suture anchor or a curved needle.Type: ApplicationFiled: June 15, 2012Publication date: October 11, 2012Inventors: Augustus D. Mazzocca, Mary Beth McCarthy
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Patent number: 8277827Abstract: This invention pertains to method for imparting a durable antimicrobial activity to substrates, particularly textiles. An acetate-free metal and peroxide antimicrobial treatment formulation is prepared by adjusting the pH of a mixture of a metal salt in aqueous hydrogen peroxide to about 7.5. The substrate is treated with the composition and dried to afford the treated substrate with antimicrobial activity. Zinc salts, ions, or complexes are preferred.Type: GrantFiled: December 17, 2010Date of Patent: October 2, 2012Assignee: Quick-Med Technologies, Inc.Inventors: William Toreki, Albina Mikhaylova, Susan Leander, Bernd Liesenfeld, Gerald M. Olderman
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Publication number: 20120245537Abstract: The invention relates to a transdermal therapeutic system made of the following layers: a carrier layer (T), an active ingredient layer (R), a membrane layer (M) and optionally an adhesive layer (K), wherein the carrier layer (T) is impenetrable to the active substance and to water, the active substance layer (R) comprises as an active substance component the salt of an alkali reactive active substance, such as a CNS-active amine in combination with at least one alkali reactive further component, and a polymer component (P1), wherein the active substance is released from the active substance layer (R) only by the moisture entering from the exterior through the membrane layer (M), and the membrane layer (M) is made of a polymer component (P2), allowing a uniform delivery of basic active substances to the skin.Type: ApplicationFiled: February 28, 2009Publication date: September 27, 2012Applicant: LTS LOHMANN THERAPIE-SYSTEME AGInventors: Michael Horstmann, Patrick Mohr, Mohammad Sameti
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Patent number: 8273404Abstract: A process for reducing solvent contents in drug-containing polymeric compositions may be utilized to reduce the solvent content in implantable medical device wherein the compositions are in reservoirs. Specifically, the solvent contents in the drug-containing polymeric compositions are first reduced by one or more conventional drying methods, to a range from about 0.5 weight percent to about 10 weight percent of the total weight of the polymeric composition. Subsequently, the drug-containing polymeric compositions are further treated by a low temperature drying method for further reduction of the solvent content.Type: GrantFiled: May 19, 2008Date of Patent: September 25, 2012Inventors: Vipul Dave, Robert Falotico, Jonathon Z. Zhao
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Publication number: 20120231060Abstract: A covalently crosslinked hydrogel comprises a) three or more divalent poly(alkylene oxide) chains P? covalently linked at respective first end units to a branched first core group C?, b) three or more divalent poly(alkylene oxide) chains P? covalently linked at respective first end units to a branched second core group C?, the chains P? comprising respective second end units which are covalently linked to between 0% and 100% of respective second end units of chains P? by divalent linking groups L?, and c) at least one pendant cationic block copolymer chain A?-B?. A?-B? comprises i) a divalent block A? comprising a poly(alkylene oxide) backbone chain having an end unit covalently linked to a second end unit of one of the chains P? by a divalent linking group L?, and ii) a monovalent block B? comprising a first repeat unit, the first repeat unit comprising a backbone carbonate group and a cationic side chain group.Type: ApplicationFiled: August 19, 2011Publication date: September 13, 2012Applicants: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Daniel Joseph Coady, Amanda Catherine Engler, James Lupton Hedrick, Shaoqiong Liu, Yi Yan Yang, Chuan Yang
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Patent number: 8257778Abstract: A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.Type: GrantFiled: March 8, 2012Date of Patent: September 4, 2012Assignee: LNK Chemsolutions, LLCInventors: Gustavo Larsen, Ruben Spretz, Raffet Velarde-Ortiz
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Publication number: 20120213912Abstract: The invention relates to a method for preventing the crystallization of a pharmaceutical in a polymer film, wherein the solvent-containing coating compound, which comprises a matrix-forming polymer or polymer mixture and at least one pharmaceutical and is spread to produce the polymer film, is temporarily dried at temperatures that is at least 10° C. above the melting temperature of the pharmaceutical contained in the coating compound. The maximum temperature is thus higher than that which is required for mere drying and obviates the need for an additional, time-consuming and expensive work step.Type: ApplicationFiled: October 26, 2010Publication date: August 23, 2012Inventors: Johannes Josef Leonhard, Walter Mueller
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Patent number: 8246876Abstract: In at least one embodiment of the present invention, a method for making embolization particles for occluding fluid flow through a body vessel is provided. The method comprises positioning an elongated body of biocompatible material relative to a cutting device. The elongated body is defined by extrusion of a body cross-section along a longitudinal axis. The elongated body is cut with a cutting device at a plurality of locations along the longitudinal axis to form the embolization particles such that each of the embolization particles has a particle cross-section that corresponds to the body cross-section.Type: GrantFiled: August 18, 2008Date of Patent: August 21, 2012Assignee: Cook Medical Technologies LLCInventor: Cleve Koehler
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Patent number: 8236715Abstract: The present invention relates to an absorbent structure suitable in, or being an adult or infant diaper or feminine hygiene article, comprising a water-absorbing material comprising water-absorbing particles that comprise a film coating, comprising an elastic film-forming polymer and a coalescing agent. The invention also relates to an absorbent structure comprising a water absorbent material obtainable by a process of: a) spray-coating water-absorbing polymeric particles with an elastic film-forming polymer in a fluidized bed reactor at a temperature in the range from 0° C. to 150° C. and b) heat-treatment of the coated polymeric particles at a temperature above 50° C., wherein in step a) and/or b) a coalescing agent is added.Type: GrantFiled: August 3, 2007Date of Patent: August 7, 2012Assignee: The Procter & Gamble CompanyInventors: Mattias Schmidt, Axel Meyer, Renae Dianna Fossum, Jean-Philippe Marie Autran, Ulrich Riegel, Thomas Daniel, Stefan Bruhns, Mark Elliott, Karl Haeberle
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Patent number: 8236214Abstract: A wet shaving system is disclosed including a blade member and a skin-engaging portion in proximity to said blade member, the skin-engaging portion comprising a solid polymeric shaving aid composite including an exposed portion containing a water-soluble shaving aid dispersed in a water-insoluble polymeric matrix, the water soluble shaving aid being coated with mineral oil.Type: GrantFiled: May 12, 2010Date of Patent: August 7, 2012Assignee: The Gillette CompanyInventor: Michael J. Kwiecien
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Publication number: 20120180699Abstract: The present invention relates to a two-component sealant comprising a first part and a second part wherein a) the first part (X) comprises: (i) a polyalkyleneoxide polymer having one or more unsaturated end groups (ii) an addition reaction catalyst b) the second part (Y) comprises: (i) an organosiloxane comprising one or more Si—H groups. The present invention also relates to medical devices used in connection with the sealant, mixing devices for delivering and mixing the first part and the second part of the sealant, and methods for applying the sealant.Type: ApplicationFiled: March 22, 2012Publication date: July 19, 2012Inventors: Peter Kwok Hing LAM, Henrik EDVARDSEN
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Patent number: 8221823Abstract: A diamond-like carbon film (DLC film) is formed on the surface of a base material made of an inorganic material, such as ceramics, or the like, or an organic material, such as resin, or the like. The surface of the resultant DLC film is treated with plasma, or the like, so as to be activated. Various monomers having biocompatibility, etc., are graft-polymerized to the activated surface of the DLC film, whereby a polymer layer is formed from the monomers grafted to the surface of the DLC film. Thus, the base material coated with the DLC film modified with a polymer which does not readily separate can be realized.Type: GrantFiled: February 1, 2010Date of Patent: July 17, 2012Assignee: Toyo Advanced Technologies Co., Ltd.Inventors: Yoshinori Abe, Tatsuyuki Nakatani, Keishi Okamoto, Kohei Shiraishi, Kazuo Sugiyama
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Publication number: 20120171355Abstract: A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.Type: ApplicationFiled: March 8, 2012Publication date: July 5, 2012Applicant: LNK CHEMSOLUTIONS, LLCInventors: Gustavo Larsen, Ruben Spretz, Raffet Velarde-Ortiz
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Publication number: 20120165770Abstract: A stimulation material is partially bonded to a pressure-sensitive adhesive to form a stimulation blend. The stimulation blend, with or without pressure-sensitive adhesive, may be juxtaposed between two substrates to form a stimulation composite. When the pressure-sensitive adhesive is present within the stimulation composite, there are regions of the adhesive that do not contain a significant amount of stimulation material. By arranging regions of stimulation blend with respect to the pressure-sensitive adhesive regions, a pattern defined by the stimulation blend is formed. This pattern may deliver a stimulation effect that is at least as effective as using one-hundred percent stimulation blend within the stimulation composite, it not more effective. The stimulation composite may be cut into countless varieties of pledget shapes for use in personal-care absorbent articles.Type: ApplicationFiled: December 28, 2010Publication date: June 28, 2012Inventors: Peiguang Zhou, Kenneth B. Close, Andrew M. Long, Gregg M. Brey, Patsy A. Benedict
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Publication number: 20120165762Abstract: A transdermal drug delivery system for the topical application of one or more active agents contained in one or more polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric backing layer which can control the delivery rate and profile of the transdermal drug delivery system by adjusting the moisture vapor transmission rate of the polymeric backing layer.Type: ApplicationFiled: August 4, 2011Publication date: June 28, 2012Inventors: David Kanios, Juan A. Mantelle, Viet Nguyen
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Publication number: 20120165957Abstract: The present invention relates to new reinforced biodegradable scaffolds for soft tissue regeneration, as well as methods for support and for augmentation and regeneration of living tissue, wherein a reinforced biodegradable scaffold is used for the treatment of indications, where increased strength and stability is required besides the need for regeneration of living tissue within a patient. The present invention further relates to the use of scaffolds together with cells or tissue explants for soft tissue regeneration, such as in the treatment of a medical prolapse, such as rectal or pelvic organ prolapse, or hernia.Type: ApplicationFiled: July 6, 2010Publication date: June 28, 2012Inventors: Hanne Everland, Lene Feldskov Nielsen, Jakob Vange, Monica Ramos Gallego
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Publication number: 20120156361Abstract: The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.Type: ApplicationFiled: February 23, 2012Publication date: June 21, 2012Inventors: Achim Müller, Monika Knuth, Ralf Pasternack, Jens Zotzel, Christine Reiff
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Publication number: 20120150194Abstract: A thread includes an elongate thread body having on its surface protruding anchoring structures that anchor in biological tissues, and a stiffening coating on the anchoring structures.Type: ApplicationFiled: May 10, 2010Publication date: June 14, 2012Applicants: ITV DENKENDORF PRODUKTSERVICE GMBH, AESCULAP AGInventors: Erich Odermatt, Ingo Berndt, Erhard Müller, Sven Oberhoffner
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Patent number: 8193406Abstract: A bandage that includes a material, which can be breathable, having a first surface, and a plurality of superhydrophobic particles attached to the first surface. The plurality of superhydrophobic particles ranging in size from about 100 nanometers to about 10 micrometers. The superhydrophobic particles including a protrusive material defining a plurality of nanopores and a plurality of spaced apart nanostructures that define an external boundary of the hydrophobic particles. The nanopores providing a flow through porosity. The first surface can be rendered superhydrophobic by the attached superhydrophobic particles. The material can have a second surface opposite the first surface that is hydrophilic. The superhydrophobic particles can be adhered to the first surface by a binder. Also included is a method of making the bandages described herein.Type: GrantFiled: November 19, 2008Date of Patent: June 5, 2012Assignee: UT-Battelle, LLCInventors: John T. Simpson, Brian R. D'Urso