Abstract: Fibrous articles having fibers coated with one or more polyelectrolyte layers are disclosed. Methods of making and using the fibrous articles are also disclosed.

Abstract: The present invention provides a pressure-sensitive adhesive tape or sheet for application to skin, which contains: a stretch fabric, and a pressure-sensitive adhesive layer provided on one surface of the stretch fabric, in which the pressure-sensitive adhesive layer contains: an acrylic copolymer obtained from a monomer mixture including an alkyl(meth)acrylate of from 40 to 80% by weight, an alkoxy (meth)acrylate of from 10 to 50% by weight and a (meth)acrylic acid of from 1 to 10% by weight; a long-chain fatty acid glycerin ester in an amount of from 20 to 100 parts by weight relative to 100 parts by weight of the acrylic copolymer, and a crosslinking agent, the pressure-sensitive adhesive layer being crosslinked with the crosslinking agent; and also provides a process for producing the tape or sheet.

Abstract: A surgical interface for a wound, obtained from a composition including a hydrophobic matrix comprising A parts of a triblock elastomer, B parts of a plasticiser, C parts of polyeolefin, and optionally a hydrocolloid dispersed in a proportion containing 0 to 30% of the total weight of the hydrophobic matrix, with the following relations: A=100 300<B<500 10<C<50 9%<C/(A+C)<33.5% 1.5%<C/(A+B+C)<9% 83%>B/(A+B)>75% in which the interface composition is arranged in a thin layer on a protective support, distributed with through-holes produced in the interface arranged on the protective support, in which the interface is removed from its protective support in order to be used, and has sufficient cohesion for application to a wound.

Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.

Abstract: A method for applying a coating composition to filaments whereby filaments are wrapped about an outer perimeter of a drum. The filament-wrapped drum is placed within a dip tank, the dip tank including a coating composition, and a least a portion of the filaments are thereby coated.

Abstract: An odor-absorbing foam composition comprising a cyclodextrin crosslinked with a polyurethane prepolymer. In one embodiment, the foam includes a ratio of the cyclodextrin to the polyurethane prepolymer selected to result in formation of the foam. The odor-absorbing foam may be used in a personal care product or wound care. A process for preparing a foam, including providing a cyclodextrin; providing a polyurethane prepolymer; combining the cyclodextrin with the polyurethane prepolymer; and allowing the polyurethane prepolymer to react with water and crosslink the cyclodextrin to form the foam. A process for preparing an odor-absorbing foam article such as a personal care product, including preparing the foam and applying it or the components thereof to a suitable substrate.

Abstract: A method for the preparation of biologically active materials is presented. The invention involves taking a base material such as allografts, xenografts, polymers, metals, and ceramics and combining it with a biologically active agent, such as proteins, cytokines, growth factors, and enzymes after which it is irradiated with ionizing radiation to sterilize and stabilize the material. The resulting biologically active material may then be stored at ambient temperature while maintaining its biological activity and the structural integrity of the base material. The invention is particularly useful for eliciting desired biological responses in human and animal medicine, and in certain industrial applications.

Abstract: A system and method are provided for targeted and individualized delivery of multiple skin benefit agents to the skin of a user. The image of a predetermined treatment area of the user's skin is first captured by an imaging device. The captured image data is then analyzed by a computing device to generate a unique skin profile for the user, which is indicative of the skin conditions at the predetermined treatment area. Based on such skin profile, a printing device prints out one or more cosmetic delivery sheets that can be applied to the predetermined treatment area. Each of the cosmetic delivery sheets contains a substrate with multiple isolate, discrete regions, while at least two of the regions are imprinted with different skin benefit agents for treating different skin conditions of the predetermined treatment area according to the unique skin profile of the user.

Abstract: The present disclosure describes a coating for a surgical suture including a vinyl lactam polymer and a lactone polymer.

Abstract: An absorbent article such as a diaper, panty diaper, panty liner, a sanitary napkin, an incontinence device or the like, includes at least a liquid-permeable topsheet made from at least one layer of web, foam or film material and a backsheet made from at least one layer of web, foam or film material, and optionally at least one further layer of web, foam or film material. At least one of the layers includes a coating of a hydrophobic thermoplastic polymer having an irregular surface and shows a contact angle of a sessile water drop of more than 110°. Depending on the location and the arrangement of this highly hydrophobic coating, beneficial effects in terms of the control of body liquids arise.

Abstract: The present invention describes methods and compositions for the reduction, prevention and elimination of biofilm formation on a surface. The present invention provides a method of depositing a coating material to reduce or prevent biofilm formation on a surface by adding a dopamine coating material to a liquid solvent to form a solution mixture, adjusting a pH of the solution mixture to 8, 9, or 10 and dissolving the dopamine coating material in the liquid solvent. The solution mixture is then placed into contact with one or more surfaces to form a dopamine coating on the surface to reduce biofilm formation.

Abstract: A custom fabricated (e.g. custom shaped and dimensioned) primary wound dressing part that matches a corresponding, pre-mapped integumentary wound is combined with dressing extension parts to form a composite wound dressing system. The primary wound dressing part may include one or more liquid flow barriers composed for example of a hydrophobic and high viscosity liquid embedded in a layer of the primary wound dressing part. The dressing extension parts may include interconnect portals for operatively interconnecting with the primary wound dressing part so that liquids may be securely moved between primary wound dressing part and the extension parts.

Abstract: Absorbent products for feminine protection, for example sanitary pads, pantiliners or tampons, comprising a cationic modified guar gum. The guar gum is modified by a cationizing agent comprising an ammonium group, wherein the degree of substitution of the cationizing agent is from about 0.070 to less than 0.30. In one aspect of the invention, the cationic modified guar gum is substantially water soluble.

Abstract: This present invention relates to a process for winding tape to prevent or reduce telescoping of the tape (e.g., dental tape) as it is wound onto a bobbin spool. Dispensers comprising such bobbins are also discussed herein.

Abstract: This present invention relates to a process for evenly and uniformly coating textured tape (e.g., dental tape).

Abstract: A face mask comprising a filter material being a fibrous substrate, especially non-woven polypropylene or polyester, having an acidic polymer, especially of the Carbopol or Gantrez type, deposited on the fibres. The mask has an anti-viral activity against inhaled or exhaled air. A filter material suitable for such a mask, and a process for making it are also described.

Abstract: The present invention relates to wound dressings, in particular to an antibacterial wound dressing based on silvered gel-forming fabric and to a process for the manufacture of such a wound dressing.

Abstract: A system and method for coating a suture are disclosed. The system includes a spool including a core having a suture wrapped thereabout and a dip tank including a first coating composition. The dip tank is configured to submerge the spool therein, thereby coating the suture with the first composition to form a pre-coated suture. The system also includes a coating device including a second coating composition. The coating device is configured to overcoat the pre-coated suture with the second coating composition.

Abstract: Coatings for implantable medical devices and methods for fabricating thereof are disclosed. The coatings include a layer comprising a hydrophobic polymer and a layer comprising a hydrophilic or amphiphilic polymer.

Abstract: Material in web form intended in particular for use in a diagnostic strip and composed of a carrier material coated on one or both sides with an ultrathin coating varnish comprising at least one anionic surfactant based on a sulphosuccinic ester salt, the ultrathin coating varnish having, after drying, a coating distribution of from 5 to 100 mg/m2.

Abstract: The invention relates to a method for assembling an adhesive device comprising a first matrix-forming material with holes and a second material, the method comprising: (a) compose the first matrix-forming material with holes; (b) compose the second material with a Tm lower than the Tm of the first material, while enabling increase in the Tm of the second material; (c) assemble the adhesive device by filling the holes of the first matrix-forming material of step (a) with the deformable second material of step (b) at a temperature where the second material is deformable and the first material is non-deformable; (d) increase the Tm of the second material.

Abstract: A solid dispersion transdermal drug delivery system comprising a therapeutic agent in a stable amorphous form and a combination polymeric stabilizing and dispersing agent having a hydrogen bond-forming functional group, and a method of manufacturing these systems is provided. The weight ratio of the combination polymeric stabilizing and dispersing agent to the therapeutic agent is also disclosed.

Abstract: A micro-needle patch has microneedles extending from a first main surface, which is made of a material including chitin and/or chitosan. The micro-needle patch has a feed substance on at least one of the first main surface and a second main surface. The micro-needle patch makes insertion of the microneedles into a living body easier. The micro-needle patch is manufactured by pressing a plate having a recessed pattern on a surface thereof, the recessed pattern including recesses corresponding to micro-needles of at least one micro-needle patch, against a sheet or film of a raw material to form protrusions corresponding to the recesses on a surface of the sheet or film.

Abstract: Disclosed is an absorbent sanitary article for absorbing body fluids which comprises a matrix containing metallic silver, wherein the silver is present bound to a fiber 24 exclusively on the surface thereof.

Abstract: The present invention relates to a self-adhesive dressing comprising a layer (1) of spunlace nonwoven material and attached thereto a layer (2) of adhesive. In accordance with the invention, the dressing is stretchable in a first direction (MD) corresponding to the machine direction of the nonwoven material and in a second direction (CD) perpendicular to the first direction, in conjunction with which the resistance to stretching is less than 10 N/25 mm in both the first (MD) and the second (CD) directions in the case of stretching of less than or equal to 5%.

Abstract: The invention relates to systems and methods for applying coatings to devices. In an embodiment, the invention includes a coating apparatus including a mandrel having a lengthwise axis and an exterior surface, the exterior surface of the mandrel defining a plurality of channels disposed parallel to the lengthwise axis, the mandrel configured to rotate around the lengthwise axis; and a spray head configured to direct a stream of material at the mandrel. In an embodiment the invention includes a method of applying a coating to a medical device. Other embodiments are also included herein.

Abstract: Described herein are implantable medical devices that can be coated with polymers and/or bioactive agents with the aid of supercritical fluids and methods for coating the devices. The medical devices described herein can have at least a portion of their surface made of or formed from a porous material. The supercritical fluids are used as a carrier for the bioactive agents described. Once the bioactive agents are carried to the medical device surface, they are sequestered there, preferably in the pores. The supercritical fluid is sprayed onto the medical devices achieving precipitation of the fluid. If appropriate conditions are used in the area of precipitation, bioactive agents can penetrate into the pores of the medical device before coming out of solution and expanding.

Abstract: A surgical garment in the form of a surgical gown, a surgical glove or a surgical mask incorporates a shear thickening fluid as a layer on at least one of the inner and outer surface of the garment, the viscosity of which shear thickening fluid increases to inhibit penetration of the garment.

Abstract: The present invention is directed to a method for imparting antimicrobial characteristics to hydrophilic fabrics. The method involves: (1) providing a hydrophilic fabric; (2) providing a first solution comprising at least one oligodynamic metal ion, wherein the first solution is free of basic nitrogen compounds; (3) contacting the hydrophilic fabric with the first solution to allow the hydrophilic fabric to absorb metal ions from the first solution; and (4) precipitating or reducing the metal ions that have been absorbed by the fabric so that the hydrophilic fabric contains an oligodynamic metal salt or free oligodynamic metal and has antimicrobial characteristics. The invention is also directed to disposable medical cloths having antimicrobial characteristics.

Abstract: The present invention relates to an antimicrobial material comprising sheet of fabric and- metallic salt crystals embedded in an adhesive material covering the sheet of fabric.

Abstract: The invention relates to membranes for haemodialysis, haemofiltration and/or plasmapheresis formed from substituted or unsubstituted cellulose carbamate having a carbamate nitrogen content in the range between 0.1 and 6%. The invention also relates to a method for manufacturing membranes of this type as well as to their use for blood detoxification within the framework of ultrafiltration, high flux dialysis, haemo-diafiltration and plasmapheresis of the blood.

Abstract: An article includes a membrane having pores and a selectively permeable coating supported by the membrane. The selectively permeable coating includes an antimicrobial agent in an amount that is sufficient to chemically react with a chemical or microbial agent to reduce the biological activity of the chemical or microbial agent or increase an amount of time for a significant amount of unreacted biologically active chemical or microbial agent to pass through the article. A laminate and methods of providing these are also provided.

Abstract: Provided are a nanoporous membrane including a support; a first separation layer with a plurality of first nano-sized pores and a first matrix; and a second separation layer having a plurality of second pores respectively corresponding to the plurality of first pores of the first separation layer and a second matrix, and formed on the first separation layer, wherein a density of the plurality of the first pores and the second pores is equal to or greater than 1010/cm2, and a diameter of each of the second pores is less than that of the corresponding first pore, a process of fabricating the same, and a device for a controlled release of biopharmaceuticals including the nanoporous membrane. The device for a controlled release of biopharmaceuticals including the nanoporous membrane can release biopharmaceuticals at a constant rate for a long period of time regardless of the concentration of the biopharmaceuticals including in pharmaceuticals, and high flex and selectivity.

Abstract: Methods, systems, and apparatuses for nanomaterial-enhanced hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. The hemostatic materials and structures may incorporate nanostructures and/or further hemostatic elements such as polymers and/or glass beads. The hemostatic materials and structures may be resorbable. Example embodiments include hemostatic bandages, hemostatic plugs, and hemostatic formulations.

Abstract: Methods for fabricating coatings for implantable medical devices are disclosed. The coatings include hydrophilic and hydrophobic components. The methods provide for treatment of the coatings to cause enrichment a region close to, at or on the outer surface of the coating with the hydrophilic component.

Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.

Abstract: A method of bonding an antimicrobial cationic polyelectrolyte to the surface of a substrate is described, wherein the antimicrobial thus attached to the substrate provides the substrate with antimicrobial properties, and at least a portion of the bonded antimicrobial is substantially non-leachable during normal conditions of use and storage. A method of manufacturing an antimicrobial material is described which comprises exposure of the substrate to a solution of antimicrobial cationic polyelectrolyte, followed by drying the exposed substrate thoroughly to impart a non-leaching property to at least a portion of the antimicrobial cationic polyelectrolytes.

Abstract: Disclosed is a coated suture thread comprising a matrix formed by an immobilized and crosslinked plurality of fibrinogen layers into and/or onto which one or several pharmacological substances that inhibit tissue break-down, such as MMP inhibitors and/or corticosteroids and/or COX inhibitors, are attached and/or associated. Further, a method of producing such a coated suture thread as well as the use thereof for suturing damaged tissue, such as damaged tendon, ligament, intestine and/or skin, are described.

Abstract: A medical device for insertion into the human body has improved sliding characteristics. The medical device for insertion into the human body includes a substrate having given shape, and an agent for improving the sliding characteristics having a hydrophilic block and a hydrophobic block, and coating the hydrophobic surface.

Abstract: The invention relates to a hydrophilic coating formulation which when cured results in a hydrophilic coating, wherein the hydrophilic coating formulation comprises a copolymeric polyelectrolyte. The invention further relates to a hydrophilic coating, a lubricious coating, use of a copolymeric polyelectrolyte in a lubricious coating, an article, a medical device or component and a method of forming on a substrate a hydrophilic coating.

Abstract: This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of reactive segmented block copolymers to the surface of the substrate by means of reactive functionalities of the terminal functionalized surfactant material reacting with complementary surface reactive functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.

Abstract: A method of producing a textile article having a localised finish is described. The method comprises providing a continuous supply of a textile substrate, providing an array of digital nozzles, supplying a finishing composition to the nozzles and selectively depositing the finishing composition from the nozzles in a series of droplets to deposit a first predetermined pattern of droplets on a selected area of the substrate to endow a functional characteristic on the selected areas. In this way, it is possible to ensure that only those areas receive the finishing composition that ultimately require it. Usage of valuable chemicals and process time can hereby be reduced.

Abstract: A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.

Abstract: A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.

Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.

Abstract: Provided herein are microprojections and microprojection arrays wherein a microprojection is coated with at least two layers. One layer comprises a biologically active agent, for example, a PTH agent and optionally other excipients. Another layer, which is generally, initially devoid of active agent comprises a polymer or a mix of polymers to provide controlled release, for example sustained release, of the biologically active agent contained in the first layer. Microprojections coated with multiple layers, some layers containing a biologically active agent and other layers containing a polymer for controlled release are also contemplated herein.

Abstract: The present invention provides a screen printable hydrogel composition comprising: (a) soluble or partially soluble polymer wherein said polymer is a copolymer, interpolymer or mixture thereof; (b) initiation system; (c) thickener; (d) water; and (e) solvent; with the proviso that the composition has a viscosity of greater than about 10 Pa·s.

Abstract: A hemorrhoid pad includes a folded laminated body having a folded end and two opposite folded halves diverging from the folded end. Each of the folded halves of the folded laminated body has inner and outer surfaces. The inner surfaces of the folded halves have a release agent coated thereon and face toward each other.

Abstract: The present invention is directed towards a method for preparing and/or treating a fluid and/or moister absorbing basic material (1), illustrated as a textile soft material, to form an allergen or allergens impregnated material (2).

Abstract: A bandage that includes a material, which can be breathable, having a first surface, and a plurality of superhydrophobic particles attached to the first surface. The plurality of superhydrophobic particles ranging in size from about 100 nanometers to about 10 micrometers. The superhydrophobic particles including a protrusive material defining a plurality of nanopores and a plurality of spaced apart nanostructures that define an external boundary of the hydrophobic particles. The nanopores providing a flow through porosity. The first surface can be rendered superhydrophobic by the attached superhydrophobic particles. The material can have a second surface opposite the first surface that is hydrophilic. The superhydrophobic particles can be adhered to the first surface by a binder. Also included is a method of making the bandages described herein.