Abstract: A process and device are disclosed for dyeing histological specimens arranged on microscope slides. The microscope slides are transported by a conveyor (18) in object slide holders to processing stations (16) where they are subjected to processing steps that correspond to a selectable dyeing process. The conveyor (18) is designed in such a way that each object slide holder (14) is separated therefrom after entering a processing station (16), so that during the time a processing step is carried out in said processing station other object slide holders (14) can be transported to free processing stations (16) according to the selected dyeing process.

Abstract: Stable suspensions of coated magnetic particles, preferably resuspendable bioactive particles particularly useful in Magnetic Resonance Imaging, are produced by disrupting, what are presumed to be, crystalline agglomerates of a parent particulate magnetic starting material in the presence of a coating material, such that coating can take place during the disruption. The particles are generally coated in suspension yielding a stable suspension of subdivided particles. With the proper selection of a coating material, preferably a protein or other biochemically or biologically active polymer such as an antibody, a resuspendable (colloidal) bioactive product is obtained.

Abstract: A process is disclosed for manufacturing paper web containing a CF layer for pressure sensitive recording paper. In order to ensure full sizing, the paper web is subjected to intermass sizing and the coating ink containing color acceptors constituted of color-reactive, mineral pigments is applied with a coating device in which the paper web is guided between two transfer rollers separated by a gap or set at minimal pressure. One of the transfer rollers applies volumetrically pre-dosed coating ink by means of a rotary and driven surface-profiled doctor bar, forming the CF layer on one side of the paper web, and the other transfer roller at the same time applies a volumetrically pre-dosed aqueous solution on the other side of the paper web, also by means of a rotary driven surface-profiled doctor bar. The amount of color-reactive pigment in the dried CF-layer comprises between 3.5 and 5 g/m.sup.2.

Abstract: Stabilized microspherical particles having hydrophobic liquid cores prepared as oil-in-water microemulsions. The particles are stabilized by a surface layer comprising an amphiphilic compound and may be functionalized to allow covalent coupling of a ligand to the surface of the particle. When used as tracers in assays, a water insoluble dye may be incorporated in the core liquid of the microparticles.

Abstract: A process for impregnating a resin into a substrate to form a web. The resin is impregnated into one side of the web, so that the other side remains exposed. This arrangement allows the exposed side of the web to be dispersible in water, while the impregnated side is water resistant. The impregnation may occur in zones and comprise one material or two or more materials. The resulting web is useful as a backsheet in disposable absorbent articles wherein it is desired to have a barrier that is impermeable to body fluids, yet flushable for disposal.

Abstract: Conformable surface finishing articles and a method for the manufacture of such articles are provided. The articles comprise a nonwoven three dimensional lofty web of fibers, a stretch resistant porous reinforcing fabric having first and second major surfaces with the first major surface disposed along a major surface of the web, and a layer comprising a polymer coated over and coextensive with the second major surface of the reinforcing fabric and having a flexible low friction exposed surface and portions extending through the reinforcing fabric encapsulating fibers along the major surface of the web.

Abstract: The invention provides photographic paper having increased image stability. The invention is generally accomplished by forming a paper sheet, drying said paper in a first stage to below about 10 percent water, then applying a polyvinyl alcohol solution to both sides of said paper sheet, drying said paper in a second stage to below about 5 percent water, and then applying further polyvinyl alcohol solution to said paper and drying in a third stage. The paper then may be coated to form a silver halide photosensitive color paper. The paper contains between about 4 and about 6 weight percent of polyvinyl alcohol that is concentrated near the surface of said paper. Further, the paper has a oxygen leak rate of less than about 25 cc/m.sup.2 /day and an oxygen GTR rate of less than about 1 cc/m.sup.2 /day.

Abstract: A tissue processor having a process chamber and at least one liquid reservoir. At least one auxiliary reservoir is connected between the process chamber and the at least one liquid reservoir. There is a means to drive liquid from the at least one liquid reservoir to the auxiliary reservoir, and from the auxiliary reservoir to the process chamber. Preferably, there is a second auxiliary reservoir and means to drive fluid from the process chamber back to the liquid reservoir. The apparatus and related method are useful to treat and fix biological tissue samples for microscopic examination.

Abstract: Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, .beta.-turn mimetics and glycerol-derived drugs is described. In order to expediently synthesize such combinatorial libraries of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.

Abstract: A granular polymer composite comprising polymeric granules having coated on a surface thereof a calcium phosphate compound, at least a part of the particles of the calcium phosphate compound penetrates into the polymeric granules. The composite has a high bonding strength between the polymeric granules as a matrix and a coating of the calcium phosphate compound and also can fully exhibit the functions of a calcium phosphate compound. Using the granular polymer composite, a diagnostic agent which comprises of an antigen or antibody is adsorbed and immobilized on the composite and is therefore useful in diagnostic tests utilizing an antigen-antibody reaction for a number of infectious diseases.

Abstract: A thermoplastic composite material may be formed by supplying the thermoplastic material to the opposite surfaces of the fabric material and by then passing the resultant material through the spaces between progressive pairs of rollers. The rollers in each progressive pair have a decreased spacing relative to the rollers in the previous pair so as to squeeze the thermoplastic material into the interstices between the fabric threads without compressing the fabric material. The resultant material may also be moved in a tortuous path, such as formed by a pair of rollers defining an S-configuration relative to the resultant material, to engage the opposite surfaces of the resultant material and squeeze air from the resultant material without compressing the fabric.

Abstract: A method and apparatus for determining surface characteristics of a layer (e.g. anodised aluminum) by measuring electrical impedance thereof and solving specified equations.

Abstract: A portion of a hydrophobic membrane, having an unknown concentration of a first molecule in a sample bound to its surface, is incubated with a second molecule that selectively binds to the first molecule so as to allow determination of its concentration. The membrane is first coated with the first molecule and then dried to render the uncoated portion nonwettable with water. The labeled second molecule selectively binds to the first molecule in the absence of a blocking agent on the membrane.

Abstract: The present invention describes a method for the manufacture of a phosphor intensifying screen which eliminates the use of solvents and high processing temperatures. The method comprises blending a phosphor in a hardenable system (i.e., that is, as defined herein, a polymerizable or curable system) comprising phosphor in a radiation curable binder composition, coating the phosphor in a radiation curable binder composition onto a substrate, and polymerizing (i.e., hardening) the system by exposure to actinic radiation. The radiation curable binder composition comprises an organopolysiloxane or a mixture of organopolysiloxanes.

Abstract: The invention relates to a flat gasket material and to a process for the production thereof and of a flat gasket therefrom. In the process according to the invention the flat gasket material is preferably constituted by an indeterminate length sheet or web of a carrier material, which is printed on one or two sides with a sealing layer. The finished printed sheet or web of indeterminate length is subsequently punched out to the desired flat gasket shape. The sealing layer is a geometrical structure that is the same on both sides of the sheet and congruent.

Abstract: An immunoassay element comprising at least one layer containing a leuco dye coating composition comprising:______________________________________ Dry Weight Component Ratio (Range) ______________________________________ a) Triarylimidazole leuco dye 55-80 b) Antioxidant 7-40 c) Poly[poly(ethylene oxide)-block- 6-20 poly(propylene oxide)] nonionic block copolymer d) Alkylaryloxypoly(alkylene oxide) 1-16 nonionic surfactant ______________________________________

Abstract: A procedure is described for wet chemical surface modification of formed articles and substrates coated with made of organopolysiloxanes: the articles formed were contacted with metal hydroxide solutions to tailor the binding capacity for ions, particularly metal ions, bivalent cations, organic macro anions, and organic macro cations, e.g. proteins. The procedure creates organopolysiloxane surfaces which are better wettable, have reduced surface resistance, are less sticky, are smoother and more biocompatible.

Abstract: Aqueous polyvinylpyrrolidone (PVP) compositions and processes employing aqueous PVP, for use in mounting hematological, cytological and histological specimens on microscope slides.

Abstract: Apparatus and process are described for impregnating a fibrous substrate with a thermosettable resin. The process involves the use of resin application means comprising a moving surface on which is positioned a liquid-form thermosettable resin in essentially uncured state, passing a fibrous web in countercurrent contact with the thermosettable resin so as to transfer the thermosettable resin into the fibrous web, and passing the resin-containing fibrous web to a heating zone to partially cure the resin and form a prepreg. The process is particularly suited for application of a solventless resin formulation to a glass web in the preparation of a prepreg for an electrical laminate.

Abstract: Lubricant is applied to the rolls of the size press to lubricate the rolls prior to moving the coating heads into their coating position by substantially simultaneously applying a lubricating film to each of the rolls of the size press in stripes symmetrically positioned relative to the center line of the web passing through the size press to in stages symmetrically relative to the axis of the web substantially equally increase the surface area of the roll to which the lubricating film is applied until the full surface corresponding to the full width of the web on each of the rolls is lubricated and then a metering rod type coating head apply coating to each of the size press rolls are simultaneously moved into coating position.

Abstract: The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods for sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromolecules, by specifically binding biologically active macromolecules to arrays of peptides or peptide mimetics.

Abstract: Embodiments of the invention provide methods of preparing an activated acridinium microparticle. Generally, the methods involve direct covalent coupling or an affinity format. The direct covalent coupling method involves coating a microparticle with a proteinaceous compound. Then, a 10-methyl-N-tosyl-N-(2-carboxyethyl)-9-acridinium carboximide trifluoromethane sulfonate is coupled to the proteinaceous compound. In the affinity format, a microparticle is coated with a biotinylated proteinaceous compound. The microparticle is reacted with an anti-biotin labelled 10-methyl-N-tosyl-N-(2-carboxyethyl)-9-acridinium carboximide trifluoromethane sulfonate. Methods are also provided for using such a microparticle. Those methods of use can estimate transfer efficiency, calibrate optics, and measure membrane pore size of a chemiluminescence based instrument. Test elements for analytical instruments are also provided.

Abstract: The invention relates generally to colloidal particle having a core material and a gelatin/aminodextran coating with pendent functional groups attached thereto. Biological substances or molecules, especially monoclonal antibodies, may be attached to said particles. The monoclonal antibody containing particles are useful in a variety of positive and negative biological assays.

Abstract: A blood collection assembly includes a container, optionally covered by a puncturable septum and evacuated. A clotting enhancer in the container activates both the intrinsic and extrinsic coagulation pathways. The invention includes a method to make the clotting enhancer.

Abstract: The present invention provides in vitro models of the in vivo rolling and arrest of leukocytes along the endothelial cell wall, which are important steps in the migration of leukocytes out of the blood stream and into tissue, as part of the inflammatory response. The in vitro models of the invention are functional under physiologic flow conditions resulting in physiologic shear stresses. In a specific embodiment, for modelling leukocyte rolling, the apparatus of the invention comprises a solid phase surface with rolling mediator molecules present thereon. Such rolling mediators are, for example, selectins and selectin ligands which have binding partners expressed on leukocytes. In another specific embodiment, for modelling leukocyte rolling followed by adhesion/arrest, the apparatus of the invention comprises a solid phase surface with both rolling mediators and integrin binding partners present thereon.

Abstract: An analytical device determines the analytes in a liquid sample. This device includes a layer of flat material which has a sample application area and a detection area thereupon. The detection area includes a reagent for determining the analyte, and the absorbent sample application area and the absorbent detection area are disposed within a liquid impermeable boundary. The layer of flat material also includes an absorbent connector which is disposed such that the sample application area and the detection area are connected by the absorbent connector. The liquid impermeable boundary and the absorbent connector prevents liquid from being transported between the sample application area and the detection area, except through the absorbent connector.

Abstract: Sizing materials are applied to porous substrates to retain fluids in the substrate for a discrete period of time. After that time period, the fluid is substantially completely released from the porous substrate. Sizing materials include alkyl ketene dimers, fluorocarbon resins, and fatty acid chlorides.

Abstract: An improved technique is provided for the expeditious formation of a supported catalyst suitable for use in a vapor phase chemical reaction wherein the catalyst is provided as discrete particles. The support need not be capable of withstanding a highly elevated temperature, and may simply be paper or any other readily available material. A layer of deformable adhesive (preferably an organic adhesive) is provided as a liquid or paste on the surface of the support. Particles of a preformed activated catalyst are dispersed on the outer surface of the adhesive so that only a minor portion of the surfaces of the particles is embedded therein. Next the adhesive is solidified under appropriate conditions while maintaining the exposure of a major portion of the surfaces of the solid preformed catalytic particles to the atmosphere. Throughout the formation process the catalytic activity of the exposed surfaces of the catalytic particles remains substantially unaltered.

Abstract: A method for silicone polymer impregnation and curing in tissue to preserve the tissue. The tissue is frozen without use of an intermediary solvent and then freeze-dried using a first vacuum. The tissue is then immersed in a non-flammable degreasing solvent, particularly 1,1,1-trichloroethane to remove lipids and the like from the tissue. The tissue is then impregnated with a silicone polymer precursor and a curing agent, and then cured under a second vacuum in a chamber (23). The impregnated polymer silicone precursor is then cured in the tissue. The tissue is preferably an anatomical specimen.

Abstract: A continuous strip coating machine has top and bottom applicator rolls and a backup roll adjacent the top applicator roll. A lift roll to lift the strip of material and thus vary the angle of wrap of the strip about the bottom applicator roll is provided. The use of the lift roll in turn varies the pressure between the strip and the roll and thus the thickness of the coating applied to the strip bottom. Thickness may be measured indirectly by measuring pressure of the strip on the applicator roll. Thickness may also be measured directly. Oscillations of the strip in a drying oven may also be sensed and compensated for. Feedback control is used with the thickness measuring techniques to control the coating thickness by varying angle of wrap, relative speed between the applicator roll and strip, and/or nip pressure between the applicator roll and a transfer roll that transfers coating material to the applicator roll.

Abstract: A method for extrusion coating both sides of a metal strip. A metal strip, such as aluminum alloy strip, is moved through a pre-conditioner, two extrusion dies, a post heater and a cooling system. Both sides of the strip are coated with thin coatings of polyester material. The coated metal strip is useful for containers, such as cans and can ends, as well as for automobiles, appliances, aerospace, construction and electrical devices.

Abstract: The invention relates to a rigid mask intended for the deposition, spreading and incubation of one or several liquids on a gel (of total surface Sg) according to one or several well-defined zones of the gel, hereafter designated by "incubation surface Si", this mask comprising:an upper surface which is in particular flat and a lower surface which is in particular flat, in particular substantially parallel to each other,at least one orifice intended to permit deposition and spreading of the liquid on the incubation surface Si of the gel, andat least one slit crossing the mask over the whole of its thickness and intended to permit withdrawal of the excess of liquid present on the incubation surface Si of the gel,the lower surface of the mask being intended to be deposited in proximity to the surface Sg of the gel, under conditions such that the lower surface of the mask is not in contact with the incubation surface Si.

Abstract: The method comprises the application of a liquid film to a paper or paperboard rawstock web in a controlled and uniform manner to achieve a moisture gradient in the Z-direction thickness of the web to a depth of less than about one-half of the web thickness, and then pressing the treated web in at least one nip of a calender device before drying the web. The liquid application plasticizes only the surface fibers of the web so that the paper fibers at or near the surface become deformed and bonded under pressure to achieve a substantially irreversible smoothness upon being rewetted in a coating application or the like.

Abstract: A method for modifying the surface of a material by:a. exposing the surface to a glow discharge plasma to activate the surface;b. exposing the surface to an ethylenically unsaturated monomer or mixture of monomers; andc. irradiating the activated surface with gamma radiation or electron beam radiation in the presence of the ethylenically unsaturated monomer to form a graft polymerized coating thereon.

Abstract: A system for wet application of a dry film, such as a photoresist, to a generally planar panel having upper and lower surfaces, such as a printed circuit board, is provided. The apparatus comprises rotatable upper and lower wetting rollers each having an absorbent material such as neoprene on the surface thereof, and a mechanism for holding the upper wetting roller in forcible contact with the lower wetting roller so that rotation of the lower wetting roller is translated into rotation of the upper wetting roller. The lower wetting roller is positioned at least partially within a container providing a supply of wetting agent, such as water, such that the wetting agent is in contact with the absorbent material on the surface of the lower wetting roller.

Abstract: A net dressing in which the net substrate is encapsulated in a hydrophilic, tacky resin, the coating on the net substrate leaving the majority of the apertures in the net substrate unoccluded and a process for preparing the dressing.

Abstract: A dispenser for blood and other biological specimens is disclosed which provides a means of obtaining a small predetermined quantity of specimen from a closed container without the need to remove the stopper from the container. The cannula of the device is caused to pierce the container's rubber stopper forming an assembly. When the said assembly is forced against a target surface, such as microscope slide, the force compresses the stopper and thereby reduces the volume inside the container sufficiently to eject a drop of fluid which is dispensed onto a target surface. Stabilizing supports are provided so that fluid emerges from a dispensing tip located a predetermined distance above the target surface which determines the quantity of fluid dispensed. The supports also transmit reactive force from the target surface to compress the rubber stopper of the closed specimen tube.

Abstract: Method and apparatus for the varnishing and printing of sheets in a printing machine. A feed drum incorporates a counterpressure surface to form a first nip with an impression cylinder. As sheets are fed to the impression cylinder and transported through the first nip, a constant pressure at the first nip consistently transfers ink to a verso side of each sheet. Arranged thereafter, a varnishing cylinder supplied with a quantity of varnish contacts the impression cylinder creating a second nip. As the sheet passes through the second nip, the recto side of the sheet is coated with the varnish. The impression cylinder thus receives a constant pressure for transferring ink to the sheet independent of the pressure provided by the varnishing cylinder. Accordingly, even a partial or intermittent varnishing of the recto sheet side has no adverse effect on print quality, and the sheet does not have to be transferred from the impression cylinder to a separate varnishing unit.

Abstract: The invention concerns a method for regulation of the moisture profile of a paper or board web in a size press in which the paper or board web (W) is made to run through a nip (N) formed by the rolls (1,2) in the size press. Films (F.sub.1,F.sub.2) of size are applied to the faces (3,4) of the rolls in the size press by means of coating devices (10,20) so that these films (F.sub.1 F.sub.2) of size are transferred onto the paper or board web (W) in the roll nip (N). A size (F.sub.1) of substantially invariable profile is spread onto the face (3) of the first roll in the size press (5), and the profile of the size film (F.sub.2) to be spread onto the face (4) of the second roll is regulated so that the moisture profile of the web (W) at the reel-up can be made substantially invariable. The invention also concerns a film size press for implementing the method.

Abstract: An improved flexible towpreg article and a method of production therefor. The improved flexible towpreg article comprises a prepreg which comprises reinforcing filaments and matrix forming material comprising recycled plastics; the reinforcing filaments being substantially wetout by the matrix forming material such that the towpreg plies have a low void content compared to the multiply towpreg.

Abstract: In the two-sided coating of a web by feeding the web through the nip of a pair of pressing rolls onto which the coating substance is metered, the amount of the coating substance applied to each pressing roll is measured by infrared absorption and the relative coating quantities RW.sub.o onto the upper side and RW.sub.u to the underside are calculated by the relationsRW.sub.o =M2.sub.o /(M2.sub.o +M2.sub.u) andRW.sub.u =M2.sub.u /(M2.sub.o +M2.sub.u); andwhere M2.sub.o represents an infrared absorption measurement of the coating on the roll applying the coating to the upper side and M2u represents the absorption measurement of the coating on the roll applying the substance to the underside of the web.

Abstract: A method of providing localized corrosion protection to products manufactured of sheet metal wherein coils of sheet metal are passed through a coil coating line wherein one or more stripes of corrosion resistant material are applied to selected areas along both the upper and lower surfaces of the metal prior to the metal being cut, punched, or bent to form a product having predetermined portions of its surface area coated. In one embodiment, a selected corrosion resistant coating is applied to galvanized sheet metal prior to the metal being punched and formed into sheet metal fasteners having coated heads but uncoated shanks.

Abstract: Zinc or zinc alloy plated steel sheet ready for deep drawing coated with 1-5 gm/m.sup.2 of a dry, tack free continuous thermoplastic acrylic coating. The coating is formed by inductively heating the sheet to a temperature of about 149.degree.-246.degree. C. for no more than 10 seconds after being roll coated with a continuous liquid film of an aqueous solution including an acrylic polymer. The acrylic coating forms a protective film that is impervious to moisture, oil, and dirt, is able to be welded and adhesively bonded and possesses sufficient toughness and lubricity to allow deformation of the sheet without additional external lubricant. A deep drawn article formed from the sheet has enhanced painting characteristics after the acrylic coating is removed and the article is coated with a phosphate coating.

Abstract: A resin-sandwiched metal laminate, a process and apparatus for producing the same and a process for producing a resin film for the resin-sandwiched metal laminate are disclosed. The laminate comprises a pair of face and back metal sheets and a resin layer and is capable of passing electricity between the face and back metal sheets, the resin layer being composed of electroconductive filler-containing resin regions at the side edges of the resin layer in the width direction of the metal sheets and an electroconductive filler-free resin center region provided between the electroconductive filler-containing resin regions at the side edges.

Abstract: An apparatus for and a method of manufacturing a fiber reinforced thermoplastic sheet-shaped molding including a pre-impregnating process and a final impregnating process. A sheet of thermoplastic resin and a web of reinforcement fibers are supplied through the pre-impregnating process during which the thermoplastic resin is sucked under the influence of a suction force so as to partially penetrate into interstices in the reinforcement fiber web while both are transported around and by a perforated rotary drum, thereby to form a first preformed sheet. The first preformed sheet is subsequently supplied to the final impregnating process during which an impregnating machine is employed. As the first preformed sheet is passed through the impregnating machine while compressed inwardly and heated, the thermoplastic resin is allowed to completely penetrate into the interstices in the reinforcement fiber web to complete the fiber reinforced thermoplastic sheet-shaped molding upon cooling thereof.

Abstract: Zinc or zinc alloy plated steel sheet ready for deep drawing coated with 1-5 gm/m.sup.2 of a dry, tack free continuous thermoplastic acrylic coating. The coating is formed by inductively heating the sheet to a temperature of about 149.degree.-246.degree. C. for no more than 10 seconds after being roll coated with a continuous liquid film of an aqueous solution including an acrylic polymer. The acrylic coating forms a protective film that is impervious to moisture, oil, and dirt, is able to be welded and adhesively bonded and possesses sufficient toughness and lubricity to allow deformation of the sheet without additional external lubricant. A deep drawn article formed from the sheet has enhanced painting characteristics after the acrylic coating is removed and the article is coated with a phosphate coating.

Abstract: A method for applying solder (S) to selective areas of a metal strip (24), wherein the strip (24) is passed between rollers (36, 38) driven through a source of molten solder (40, 42) to transfer a coating a solder (S) to the strip (24). The rollers include discontinuous surfaces (37, 39) suitably shaped to provide selective areas of solder coating (S) on the strip (24).

Abstract: A water-repellent leather game ball is provided by applying a water-repellent material to one side of a plurality of leather panels, securing the leather panels together to form the ball so that said one side of the panels are inside of the ball, and applying a coating of water-repellent material to the outisde surface of the ball.

Abstract: Apparatus for maintaining a relatively placid pool of liquid coating material in the trough between two nipped rolls comprises a pair of deckles, one disposed near either end of the nipped rolls, each of the deckles having an edge generally conforming to a segment of the adjacent roll to effectively form an end of the trough formed by the rolls. At least one of the deckles has one or more openings which permit the liquid coating material to flow laterally out of the trough and through the deckle at a rate proportional to the depth of the coating material in the trough. Controlling the lateral outward flow of material from the trough stabilizes both the turbulence of the liquid coating material in the trough and the surface condition of the coating material.

Abstract: The method includes the steps of coating the peripheral surface of a roll with a film of plasticizer. An offset roll disposed adjacent to the roll is rotated such that the roll and the offset roll define therebetween a transfer nip so that a film of the plasticizer is transferred to the offset roll. The web is moved past the offset roll such that the web contacts the offset roll downstream relative to the transfer nip so that the film of the plasticizer is offset onto the web. The web is then passed with the offset coating of plasticizer through a calendering nip such that between the offset coating of the web and the subsequent calendering of the web with the offset coating, the plasticizer is permitted to uniformly and controllably penetrate into the web such that the Z-directional compressibility of the web is controlled prior to the web extending through the calendering nip.