Involving Transferase Patents (Class 435/15)
-
Patent number: 12264339Abstract: The disclosure provides polypeptides comprising an engineered p27, or a fragment thereof such polypeptides may be used to form trimeric protein complexes with a cyclin-dependent kinase 4 (Cdk4) (or a variant thereof) or Cdk6 (or a variant thereof), and a cyclin D (CycD) or a variant thereof.Type: GrantFiled: May 16, 2023Date of Patent: April 1, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Seth Rubin, Keelan Guiley
-
Patent number: 12196757Abstract: Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.Type: GrantFiled: December 28, 2021Date of Patent: January 14, 2025Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Benjamin Katchman, Karen Anderson, Garrick Wallstrom, Joshua LaBaer, Daniel Cramer
-
Patent number: 12173281Abstract: Bistable devices are constructed using a polynucleotide platform for sensing molecular events such as binding or conformational changes of target molecules. Uses include measuring target concentration, measuring effects of environmental conditions on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices include three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration in which they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Devices may carry DNA tags to enable separation of open and closed devices and barcoding for multiplexed detection.Type: GrantFiled: December 3, 2021Date of Patent: December 24, 2024Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Ashwin Gopinath, Paul W. K. Rothemund
-
Patent number: 12105096Abstract: The present invention is directed to a method for predicting the risk of a female subject to develop postpartum HELLP syndrome, postpartum preeclampsia, or postpartum eclampsia. The method is based on the determination of the levels of i) sFlt-1 and PlGF, or ii) Endoglin and PlGF in a first sample obtained from said subject before delivery of baby, and a second sample of from said subject obtained after delivery of baby. Moreover, encompassed by the invention are devices and kits for carrying out the method of the present invention.Type: GrantFiled: August 20, 2020Date of Patent: October 1, 2024Assignee: Roche Diagnostics Operations, Inc.Inventors: Martin Hund, Thomas Dieterle, Olav Lapaire
-
Patent number: 12024736Abstract: The present disclosure provides a method for detecting L-serine based on Escherichia coli cysteine desulfurase, and belongs to the technical field of amino acid detection. The method includes the steps of: reacting an unknown sample containing L-serine with E. coli cysteine desulfurase in vitro to produce a red substance, and qualitatively or quantitatively determining L-serine content in the unknown sample by observing a color of the red substance or determining content thereof. The method provided by the present disclosure is simple and feasible in technical operation, few in reaction steps, and capable of directly qualitatively detecting by naked eyes and quantitatively detecting the L-serine content.Type: GrantFiled: July 22, 2022Date of Patent: July 2, 2024Assignee: WENZHOU MEDICAL UNIVERSITYInventors: Guoqiang Tan, Jianghui Li, Feng Liang, Yilin Pang
-
Patent number: 11964002Abstract: The present invention relates to the field of recombinant protein production in a host cell. More specifically the invention relates to the field of oral protein delivery. Specifically, the invention provides oral pharmaceutical formulations comprising the culture medium of a recombinant host secreting a recombinant protein. The resulting oral pharmaceutical formulations are useful for the treatment of gastro-intestinal and/or buccal disorders. Additionally, the oral pharmaceutical formulations are useful for prophylactic and vaccine purposes.Type: GrantFiled: February 28, 2018Date of Patent: April 23, 2024Assignees: VIB VZW, Universiteit GentInventors: Nico Callewaert, Robin Vanluchene, Bram Laukens, Anna Depicker, Vikram Virdi
-
Patent number: 11933784Abstract: Disclosed are compositions and methods to detect proteins associated with Head and Neck Cancer, generally, or more particularly, biomarkers of Head and Neck Squamous Cell Carcinoma (HNSCC). Such markers may be useful to allow individuals susceptible to HNSCC to manage their lifestyle and/or medical treatment to avoid further progression of disease.Type: GrantFiled: December 19, 2018Date of Patent: March 19, 2024Assignee: Laboratory Corporation of America HoldingsInventor: Gerald J. Wallweber
-
Patent number: 11927594Abstract: The present disclosure describes a method of quantifying amounts of phosphopeptides using isotopically-enriched peptides as internal standards. A kit comprising at least one isotopically-enriched phosphorylated peptide can be used to quantify changes in amounts of phosphopeptides using parallel reaction monitoring mass spectrometry techniques. The invention can be used to indicate the pathologic mechanism, severity of the disease, and treatment response of a subject. The invention can also be used to identify subjects who require more aggressive therapeutic interventions or alternative treatments.Type: GrantFiled: February 7, 2020Date of Patent: March 12, 2024Assignee: RENSSELAER CENTER FOR TRANSLATIONAL RESEARCH, INC.Inventor: Lawrence S. Zisman
-
Patent number: 11815507Abstract: The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel. The system may comprise a processor configured to analyze the image using a deep learning algorithm to enable sorting of the cell.Type: GrantFiled: February 11, 2021Date of Patent: November 14, 2023Assignee: Deepcell, Inc.Inventors: Mahdokht Masaeli, Mahyar Salek, Hou-Pu Chou, Soroush Kahkeshani, Prashast Khandelwal, Syed Tariq Shafaat
-
Patent number: 11807858Abstract: The present invention relates to methods and compositions for transforming soybean, corn, cotton, or canola explants using spectinomycin as a selective agent for transformation of the explants. The method may further comprise treatment of the explants with cytokinin during the transformation and regeneration process.Type: GrantFiled: December 10, 2020Date of Patent: November 7, 2023Assignee: MONSANTO TECHNOLOGY LLCInventors: Brian J. Martinell, Michael W. Petersen, David A. Somers, Yuechun Wan, Edward Williams, Xudong Ye
-
Patent number: 11802297Abstract: The present invention relates to an improved method for cell line development (CLD) which is generally applicable to production of any therapeutic protein that can be produced using mammalian Cell lines and in particular Chinese Hamster Ovary (CHO) cells. The method combines site-directed integration (SDI), expression construct components improving the post-transcriptional processing of the gene of interest (GOI) and the introduction of a onetime pre-CLD host cell line selection workflow to generate a production competent cell line that can then be used in multiple CLD efforts using SDI from that point on.Type: GrantFiled: February 23, 2018Date of Patent: October 31, 2023Assignee: Cytiva Sweden ABInventors: Daniel Ivansson, Andreas Castan
-
Patent number: 11739371Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes. The invention also relates to manufacturing and using molecular arrays and analytical approaches based on single molecule detection techniques.Type: GrantFiled: February 18, 2016Date of Patent: August 29, 2023Assignee: Invitae CorporationInventors: Patrick James Collins, Adrian Nielsen Fehr, Jill Lyndon Herschleb, Hywel Bowden Jones
-
Patent number: 11527323Abstract: Systems and methods are provided for identifying a diagnosis of a cancer condition for a somatic tumor specimen of a subject. The method receives sequencing information comprising analysis of a plurality of nucleic acids derived from the somatic tumor specimen. The method identifies a plurality of features from the sequencing information, including two or more of RNA, DNA, RNA splicing, viral, and copy number features. The method provides a first subset of features and a second subset of features from the identified plurality of features as inputs to a first classifier and a second classifier, respectively. The method generates, from two or more classifiers, two or more predictions of cancer condition based at least in part on the identified plurality of features. The method combines, at a final classifier, the two or more predictions to identify the diagnosis of the cancer condition for the somatic tumor specimen of the subject.Type: GrantFiled: May 12, 2020Date of Patent: December 13, 2022Assignee: Tempus Labs, Inc.Inventors: Jackson Michuda, Kyle Ashley Beauchamp, Joshuah Kapilivsky, Calvin McCarter, Nike Beaubier, Martin Christian Stumpe, Catherine Igartua, Joshua S K Bell, Timothy Taxter, Raphael Pelossof
-
Patent number: 11466300Abstract: This Invention discloses a method for production of N-Acetyl-D-Glucosamine and/or D-Glucosamine Salt by microbial fermentation. The method is intended to manufacture N-Acetyl-D-Glucosamine and/or D-Glucosamine Salt in higher efficiency and higher yield, by increasing the effects of N-Acetyl-D-Mannosamine Kinase.Type: GrantFiled: April 14, 2017Date of Patent: October 11, 2022Inventor: Lan Sun
-
Patent number: 11460474Abstract: The present disclosure is directed to a method of identifying a patient having heart failure as likely to respond to a therapy with a statin. The method is based on measuring the level of at least one marker selected from GDF-15 (Growth Differentiation Factor 15), Urea, SHBG (Sex Hormone-Binding Globulin), Uric acid, PLGF (Placental Growth Factor), IL-6 (Interleukin-6), Transferrin, a cardiac Troponin, sFlt-1 (Soluble fms-like tyrosine kinase-1), Prealbumin, Ferritin, Osteopontin, sST2 (soluble ST2), and hsCRP (high sensitivity C-reactive protein) in a sample from a patient. Further envisaged is a method of predicting the risk of a patient to suffer from death or hospitalization, wherein the patient has heart failure and undergoes a therapy with a statin. The method is also based on the measurement of the level of at least one of the aforementioned markers.Type: GrantFiled: January 25, 2019Date of Patent: October 4, 2022Assignee: Roche Diagnostics Operations, Inc.Inventors: Dirk Block, Hanspeter Brunner, Thomas Dieterle, Ursula-Henrike Wienhues-Thelen, Christian Zaugg, Andre Ziegler
-
Patent number: 11307204Abstract: The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) and detecting the conversion of 5-ALA to protoporphyrin IX (PPIX) associated with brain-derived microparticles.Type: GrantFiled: June 7, 2019Date of Patent: April 19, 2022Assignee: PIOMA, INC.Inventor: Alan M. Ezrin
-
Patent number: 11273161Abstract: Methods of diagnosing and treating autism spectrum disorders are provided.Type: GrantFiled: June 12, 2019Date of Patent: March 15, 2022Assignee: The Broad Institute, Inc.Inventors: Jon Madison, Jeffrey Cottrell
-
Patent number: 11274325Abstract: Provided herein, inter alia, are methods, bacteria, nucleic acids, and polypeptides for producing sialylated oligosaccharides.Type: GrantFiled: December 14, 2018Date of Patent: March 15, 2022Assignee: Glycosyn LLCInventors: Srikrishnan Mallipeddi, Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
-
Patent number: 11242550Abstract: The present invention discloses a method for preparing glucosyl steviol glycosides through enzymatic catalysis under programming temperatures in high throughput, belonging to the technical field of biosynthesis of sweeteners. By using cyclodextrin glucosyltransferase from Geobacillus sp. as a catalyst, steviol glycosides as the glycosyl receptor and dextrin or oligosaccharide as the glycosyl donor, taking a calcium/barium ion salt bridge as the main stabilizer and combining with glycerol to adjust the conformation and binding domain openness of the enzyme, and utilizing transglucosylation and hydrolytic activities of amylase at variable temperatures in different stages, thereby preparing the glucosyl steviol glycosides through enzymatic catalysis under programming temperatures in high throughput. The technology of the present invention can improve the utilization rate of the enzyme, and obtain glucosyl steviol glycosides with good sweetness and good taste.Type: GrantFiled: December 5, 2018Date of Patent: February 8, 2022Assignees: Jiangnan University, DONGTAI HAORUI BIOTECHNOLOGY CO., LTD.Inventors: Yongmei Xia, Liping Zhu, Yun Fang, Xiang Liu, Haijun Wang
-
Patent number: 11236061Abstract: The present specification provides a compound represented by Chemical Formula 1, a colorant composition, a resin composition, a photosensitive material, a color filter and a display device comprising the same.Type: GrantFiled: February 26, 2020Date of Patent: February 1, 2022Assignee: LG CHEM, LTD.Inventors: Jongho Park, Dami Lee, Seung Jin Yang, Jihye Jung
-
Patent number: 11220703Abstract: Provided herein are analytical methods utilizing a self-limiting catalytic reaction, and compositions and kits useful therefore. In one aspect the method is used to quantify Pd, and in another, the method is a horseradish peroxidase assay.Type: GrantFiled: November 23, 2016Date of Patent: January 11, 2022Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Merck Sharp & Dohme Corp.Inventors: Xiaodong Bu, Junyong Jo, Kazunori Koide, Matthew Patrick Tracey, Christopher J. Welch
-
Patent number: 11124843Abstract: Provided is a method for detecting a bacterium of the genus Nitrobacter, comprising: a first step of amplifying a nucleotide using a test DNA as a template and primers capable of amplifying a nucleotide sequence of consecutive 110 nucleotides or more and 157 nucleotides or less in the nucleotide sequence set forth in SEQ ID NO: 1 to obtain an amplified product; and a second step of detecting the amplified product.Type: GrantFiled: March 30, 2016Date of Patent: September 21, 2021Assignee: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Tomokazu Mitsui
-
Patent number: 11066649Abstract: The invention relates to a method for inducing human cholangiocyte differentiation of progenitor cells called hepatoblasts. More specifically, the invention relates to a method for differentiating hepatoblasts to cholangiocytes by culturing said hepatoblasts with a particular medium having interleukin-6 (IL-6) activity. The differentiation method can specifically induce cholangiocyte differentiation from hepatoblasts, and the human cholangiocytes differentiated according to the invention may be useful for drug discovery for treatment of cholangiopathies and bioengineered livers.Type: GrantFiled: March 19, 2015Date of Patent: July 20, 2021Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITÉ PARIS-SACLAY, UNIVERSITE DE RENNESInventors: Anne Dubart Kupperschmitt, Anne Weber Benarous, Anne Corlu, Noushin Dianat
-
Patent number: 11021703Abstract: This invention relates to a method of characterizing the modified base status of a transcriptome, which involves contacting a transcriptome comprising one or more modified bases with an antibody specific to the modified bases under conditions effective to bind the antibody to the modified bases; isolating, from the transcriptome, a pool of RNA transcripts to which the antibody binds; and identifying isolated RNA transcripts that are present in a higher abundance in the isolated pool relative to the transcriptome, where each of the isolated RNA transcripts that are present in a higher abundance in the isolated pool together characterize the modified base status of the transcriptome. Also disclosed are a method of diagnosis or prognosis of a disease, a method of determining the effect of a treatment on modified base levels in RNA, and a kit for characterizing the modified base status of a transcriptome.Type: GrantFiled: February 18, 2013Date of Patent: June 1, 2021Assignee: CORNELL UNIVERSITYInventors: Samie R. Jaffrey, Kate D. Meyer, Christopher E. Mason
-
Patent number: 10975440Abstract: Sets of experimentally validated gene specific primer pairs are provided. Embodiments of the sets include 10 or more gene specific primer pairs of forward and reverse primers. The forward and reverse primers of each primer pair include gene specific primers that are experimentally validated as suitable for use in a multiplex amplification assay. In some instances, each of the forward and reverse primers includes an anchor domain that includes a universal primer binding site. The sets find use in a variety of different applications, including high-throughput sequencing applications.Type: GrantFiled: April 19, 2016Date of Patent: April 13, 2021Assignee: Cellecta, Inc.Inventors: Alex Chenchik, Costa Frangou, Mikhail Makhanov
-
Patent number: 10883992Abstract: The invention provides kinase substrates and methods comprising their use.Type: GrantFiled: February 22, 2019Date of Patent: January 5, 2021Assignees: Regents of the University of Minnesota, Yale UniversityInventors: Laurie L. Parker, Wei Cui, Benjamin Turk
-
Patent number: 10870894Abstract: Methods for detecting microorganisms, in particular detection of bacteria and methods for measuring enzyme activity, such as Deoxyribonucleic acid (DNA) polymerase activity are disclosed. The aforesaid methods include, but are not limited to such methods performed on microbial crude lysates, useful for determining microbial enzyme activities, which can be linked to amplification signal generators such as real-time Polymerase Chain Reaction (PCR) techniques, thereby enabling determination of microbial pathogens in samples such as unpurified blood and other body fluids. Moreover, the disclosed embodiments also relate to reagents for use in such methods, and to test kits comprising such reagents for carrying out the methods.Type: GrantFiled: June 12, 2015Date of Patent: December 22, 2020Inventors: Shawn Mark O'Hara, Daniel Zweitzig
-
Patent number: 10865392Abstract: The present invention relates to acetyl transferases, nucleic acid sequences coding therefore, expression constructs and vectors comprising these sequences, microorganisms transformed therewith and use thereof.Type: GrantFiled: October 4, 2019Date of Patent: December 15, 2020Assignee: DSM IP ASSETS B.V.Inventors: Christopher Farrell, Peter Houston, Lisa Laprade, Nathalie Balch, Maria Mayorga
-
Patent number: 10813931Abstract: The compositions and methods described herein relate to the treatment of cancer, e.g. by reducing the regression of cancer cells from regressing into cancer stem cell-like phenotypes and/or reducing the development of drug-resistant cancer cells. In some embodiments, the compositions and methods relate to inhibitors of PI3K pathway kinases and Src family kinases.Type: GrantFiled: February 12, 2014Date of Patent: October 27, 2020Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Aaron Goldman, Ashish Kulkarni, Shiladitya Sengupta
-
Patent number: 10793894Abstract: Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation.Type: GrantFiled: February 20, 2019Date of Patent: October 6, 2020Assignee: BIOMARIN PHARMACEUTICAL INC.Inventors: Brett E. Crawford, Jillian R. Brown, Charles A. Glass, Jim R. Beitel, Robin M. Jackman
-
Patent number: 10731200Abstract: A method of quantifying ammonia, which method includes: performing a first reaction in which a test liquid containing ammonia is reacted with ATP and L-glutamic acid in the presence of glutamine synthetase to produce ADP; performing a second reaction in which the produced ADP is reacted with glucose in the presence of ADP-dependent hexokinase to produce glucose-6-phosphate; performing a third reaction in which the produced glucose-6-phosphate is reacted with an oxidized NAD compound in the presence of glucose-6-phosphate dehydrogenase to produce a reduced NAD compound; and quantifying the reduced NAD compound to quantify ammonia.Type: GrantFiled: October 19, 2017Date of Patent: August 4, 2020Assignee: ARKRAY, Inc.Inventors: Takehiro Funamoto, Masaki Murakami
-
Patent number: 10724015Abstract: The present invention relates to a mutant microorganism in which a gene that encodes phosphofructokinase-2 is disrupted or deleted to reduce glycolytic flux to thereby improve the ability of the microorganism to produce N-acetylglucosamine, and to a method of producing N-acetylglucosamine using the mutant microorganism. The mutant microorganism according to the present invention has advantages in that it has high resistance to various chemical substances, grows rapidly, is easily cultured, and produces N-acetylglucosamine with high efficiency, indicating that it is useful for production of a large amount of N-acetylglucosamine.Type: GrantFiled: May 17, 2017Date of Patent: July 28, 2020Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATIONInventors: Min-Kyu Oh, Sang-Woo Lee
-
Patent number: 10697870Abstract: An object is to provide a blood test kit and a blood analysis method capable of performing a blood test with a small amount of blood at high accuracy by visualizing a volume of blood collection and keeping the volume constant. Provided is a blood test kit for analyzing a concentration of a target component in a blood sample using a normal component homeostatically present in blood, the kit including: a blood collection instrument for collecting the blood sample; a diluent solution for diluting the collected blood sample; and a storing instrument for storing the diluted blood sample, in which the blood collection instrument is a capillary.Type: GrantFiled: January 3, 2018Date of Patent: June 30, 2020Assignee: FUJIFILM CorporationInventors: Hikaru Urano, Tatsuya Ishizaka, Haruyasu Nakatsugawa, Susumu Osawa, Shinya Sugimoto
-
Patent number: 10688153Abstract: Modified peptides based on C-terminal PDZ binding domains of PTEN and PHLPP, or PDK1 interacting fragment of PKN2 are described as are methods of using the modified peptides for blocking the activity of PTEN, PHLPP and PKN2 and treating sudden cardiac arrest. A method for guiding treatment of cardiac arrest based on sorbitol or taurine levels is also provided.Type: GrantFiled: November 7, 2016Date of Patent: June 23, 2020Assignee: The Board of Trustees of the University of IllinoisInventors: Terry Vanden Hoek, Xiangdong Zhu, Jing Li
-
Patent number: 10677786Abstract: Provided herein are methods of diagnosing or monitoring the treatment of mucopolysaccharidosis (MPS) I or a disorder associated with MPS I.Type: GrantFiled: February 8, 2018Date of Patent: June 9, 2020Assignee: BIOMARIN PHARMACEUTICAL INC.Inventors: Brett E. Crawford, Jillian R. Brown, Charles A. Glass, Jim R. Beitel, Robin M. Jackman
-
Patent number: 10632150Abstract: Disclosed herein is a sterile composition for injection comprised of potassium phosphates having no visible particulate. Also disclosed herein is a manufacturing process for the sterile composition and its use.Type: GrantFiled: April 19, 2019Date of Patent: April 28, 2020Assignee: CMP Development LLCInventors: H. Greg Thomas, Richard LeVasseur, Jeffrey S. Kiel, Anthony Reid Pipho
-
Patent number: 10619186Abstract: The disclosure provides for methods, compositions, and kits for normalizing nucleic acid libraries, for example sequencing libraries.Type: GrantFiled: September 8, 2016Date of Patent: April 14, 2020Assignee: Cellular Research, Inc.Inventors: Craig Betts, Glenn Fu
-
Patent number: 10596209Abstract: The present invention relates to the identification of a group of microorganisms, which are relatively abundant in the microbial communities associated with fruits and vegetables typically consumed raw and therefore transient or permanent members of the human microbiota. The consumption of mixtures of these microbes at relevant doses will produce a beneficial effect in the host by reducing the propensity to diabetes, obesity and metabolic syndrome mediated in part by production of short chain fatty acids to enhance colonic butyrate production. Therapeutic methods of the invention involve the use of live microorganisms or metabolites derived from said microorganisms to establish a microbial composition in the mammalian host that will improve significantly the ability to control weight, reduce the onset of diabetes, obesity and metabolic syndrome, and improve overall health.Type: GrantFiled: December 28, 2018Date of Patent: March 24, 2020Assignee: Solarea Bio, Inc.Inventors: Gerardo V. Toledo, Tracy Mincer, Jahir Mauricio Gutierrez Bugarin, Jillian DeWalt, Eric Schott, Maria Juliana Soto Giron
-
Patent number: 10590168Abstract: The invention provides kinase substrates and methods comprising their use.Type: GrantFiled: May 23, 2017Date of Patent: March 17, 2020Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Laurie L. Parker, Minervo Perez
-
Patent number: 10585270Abstract: A multi-plane imaging system for imaging multiple reflection planes of a regular or irregular shaped three-dimensional (3D) specimen having top, side and bottom views simultaneously. The system includes an inverted watertight pyramid well having at least four reflective side surfaces for reflecting the specimen side views, wherein each of the at least four reflective sides surfaces define an angle, ?, relative to the base horizontal plane, and wherein each reflective side surface comprises a plurality of reflective zones; A specimen is positioned horizontally equidistant from the at least four reflective side surfaces and positioned vertically from the base horizontal plane a predetermined vertical distance; wherein the predetermined vertical distance, the at least four reflective side surfaces, and the angle ? comprise a reflection image plane for reflecting the specimen bottom views.Type: GrantFiled: October 25, 2018Date of Patent: March 10, 2020Assignee: University of Vermont and State Agricultural CollegeInventors: Nathan R Tykocki, Grant Hennig
-
Patent number: 10570176Abstract: The present invention relates to the field of polypeptide medicine, and relates to polypeptides against hepatitis B virus X Protein and uses thereof. Specifically, the present invention relates to polypeptides comprising D-amino acids, which have a function of inhibiting hepatitis B virus X protein, and inhibit HBx activities, inhibit replication of hepatitis B virus DNA and expression of related antigens (e.g., HBeAg) at molecular level, cellular level and animal level, and further inhibit hepatitis and hepatic cirrhosis caused by hepatitis B virus infection and liver cancer that occurs on the basis of hepatic cirrhosis. The polypeptides can be widely used in the prevention and treatment of liver diseases after hepatitis B infection, including hepatitis, hepatic cirrhosis, and liver cancer.Type: GrantFiled: October 16, 2015Date of Patent: February 25, 2020Assignee: Tianjin TOPTECH Bio-Science & Technology Co., Ltd.Inventors: Xiaodong Zhang, Lihong Ye
-
Patent number: 10548948Abstract: Antifungal pharmaceutical compositions, dosage forms, and methods of use thereof are disclosed.Type: GrantFiled: February 27, 2018Date of Patent: February 4, 2020Assignee: The United States of America as represented by the Secretary of the NavyInventors: Nancy Millenbaugh, Jeremy Wesley Gleaton, Dickson Kiprono Kirui
-
Patent number: 10475942Abstract: A photodetector cell may include a substrate, and a first contact carried by the substrate and having a first work function value. The photodetector cell may include a second contact carried by the substrate and having a second work function value different from the first work function value, and a semiconductor wire carried by the substrate and having a third work function value between the first and second work function values. The semiconductor wire may be coupled between the first and second contacts and comprising a photodiode junction.Type: GrantFiled: May 14, 2018Date of Patent: November 12, 2019Inventors: Manjeri P. Anantram, Md Golam Rabbani, Mahmoud M. Khader, Reza Nekovei, Amit Verma
-
Patent number: 10449182Abstract: The present invention provides sorafenib analogs for use in a method of treating a disease mediated by p21, said method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I. The present invention also provides methods of inhibiting p21 in a cell comprising contacting the cell with an effective amount of a compound of formula I.Type: GrantFiled: June 20, 2013Date of Patent: October 22, 2019Assignee: The Regents of the University of CaliforniaInventors: Robert H. Weiss, Bruce D. Hammock, Hiromi Inoue Wettersten, Sung Hee Hwang
-
Patent number: 10453554Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.Type: GrantFiled: November 7, 2014Date of Patent: October 22, 2019Assignee: Codexis Mayflower Holdings, Inc.Inventor: Richard John Fox
-
Patent number: 10422006Abstract: Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the PI3K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the PI3K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target.Type: GrantFiled: October 31, 2014Date of Patent: September 24, 2019Assignee: The John Hopkins UniversityInventors: Yardena Samuels, Victor Velculescu, Kenneth W. Kinzler, Bert Vogelstein
-
Patent number: 10405810Abstract: A tool for predicting that a person is likely to be abnormally hydrated over a future time interval, and in some cases to alert the person or a medical professional to intervene. From a series of physiological measurements, a tissue electrical impedance spectrum curve, which comprises a phase spectrum curve in an embodiment, is determined and changes in the shape of the curve are ascertained. The measurements may be received using one or more sensors worn by the person. In some embodiments, current and historic spectrum curvature are applied to an evolutionary algorithm, such as particle-swarm optimization (PSO) or differential evolution (DE), to determine an inference regarding the persons future hydration status. In one embodiment, a statistical forecast for the next epoch immediately beyond the present one, is determined.Type: GrantFiled: May 23, 2016Date of Patent: September 10, 2019Assignee: Cerner Innovation, Inc.Inventor: Douglas S. McNair
-
Patent number: 10407735Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ncRNAs as diagnostic markers and clinical targets for prostate, lung, breast and pancreatic cancer.Type: GrantFiled: May 17, 2016Date of Patent: September 10, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Arul Chinnaiyan, John Prensner, Matthew Iyer
-
Patent number: 10364425Abstract: The invention is related to a composition of recombinant or transgenic Factor VII, each molecule of Factor VII of the composition exhibiting two N-glycosylation sites, wherein, among all the molecules of FVII of the composition, the rate of Gal?1,3G al glycan moieties is comprised between 0 and 4%. The invention is also related to a process for preparing such a composition of FVII.Type: GrantFiled: May 2, 2013Date of Patent: July 30, 2019Assignee: LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIESInventors: Abdessatar Sami Chtourou, Emmanuel Nony, Nicolas Bihoreau
-
Patent number: RE49518Abstract: [Problem] To provide a fluorescent probe that detects calpain activity in cells at high sensitivity. [Solution] A compound represented by the following general formula (I) or a salt thereof.Type: GrantFiled: May 21, 2021Date of Patent: May 2, 2023Assignees: The University of Tokyo, Tohoku UniversityInventors: Yasuteru Urano, Yuri Nagayo, Mako Kamiya, Toru Nakazawa