Abstract: A species of Nocardia, designated Nocardia argentinensis Huang ATCC 31438, when subjected to aerobic submerged fermentation, produces an antibiotic complex containing as its major component antibiotic Compound 51,467. Methods for the recovery and purification of antibiotic Compound 51,467 and minor antibiotic components, Compounds 52,726 and 52,748, and some of their properties are outlined.
Type:
Grant
Filed:
March 2, 1979
Date of Patent:
September 23, 1980
Assignee:
Pfizer Inc.
Inventors:
Walter D. Celmer, Paul C. Watts, Walter P. Cullen, Liang H. Huang, Riichiro Shibakawa, Junsuke Tone
Abstract: A method for the oxidation of hydrocarbons to monocarboxylic acids and thence to dicarboxylic acids by the aerobic resting cell reaction of the organism Debaryomyces phaffii ATCC 20499.
Abstract: Antibiotics aculeacin-A.alpha., -A.gamma., -D.alpha. and -D.gamma. are active against yeasts and fungi. They are produced by culturing the microorganism Aspergillus aculeatus NRRL 11270 in a nutrient medium containing assimilable carbon and nitrogen sources.
Abstract: EMITANIN having antitumor activity is produced by inoculating mycelia of Tricholoma matsutake, Tricholoma baka-matsutake, Volvariella volvacea or Tremella fuciformis in a medium for growing mycelia and fermenting the grown mycelia in a liquid medium containing a carbohydrate and a nitrogen source and isolating solid substance of mycelia from a broth and extracting the solid substance of mycelia and isolating the active ingredient.
Abstract: KS-substance was obtained as raw material from the cultured mycelium of Daedalea dickinsii KSDD 6 (FERM-P No. 3993), Lentinus edodes KSLE 7 (FERM-P No. 3994) or Lentinus edodes KSLE 28 (FERM-P No. 4196), and by refining this substance a novel substance KS-2-A was obtained. This substance KS-2-A and also the KS-substance as the raw material both enhance the host defense function of the living body.