Streptomyces Patents (Class 435/252.35)
  • BMP-4 PEPTIDES AND METHODS OF USE
    Publication number: 20130196910
    Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors.
    Type: Application
    Filed: March 24, 2011
    Publication date: August 1, 2013
    Applicant: LIFENET HEALTH
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
  • Polyol Oxidases
    Publication number: 20130196891
    Abstract: The present invention provides compositions and methods for producing a polyol oxidase in micoroorganisms, and the use of polyol oxidases in cleaning compositions. The invention includes cleaning compositions that contain combinations of two or more POx oxidases, and cleaning compositions that contain combinations of two or more POx oxidases and a perhydrolase. In particular, the invention provides methods for expressing polyol oxidases in bacterial hosts for use in detergent applications for cleaning, bleaching and disinfecting.
    Type: Application
    Filed: January 18, 2013
    Publication date: August 1, 2013
    Applicant: DANISCO US INC.
    Inventor: Danisco US Inc.
  • Polypeptides Having Endoglucanase Activity And Polynucleotides Encoding Same
    Publication number: 20130196387
    Abstract: The present invention provides isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cell comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: November 11, 2011
    Publication date: August 1, 2013
    Applicant: Novozymes Inc.
    Inventors: Ye Liu, Junxin Duan, Lan Tang
  • NOVEL TRANSAMINASE EXHIBITING HIGH ACTIVITY FOR GLUTAMIC ACID, GENE ENCODING SAME, AND METHOD FOR USING THEM
    Publication number: 20130196389
    Abstract: A method for inexpensively and efficiently producing an optically active amino compound useful as an intermediate for pharmaceutical preparations, agricultural chemicals, or the like, from a ketone compound is provided. Specifically, a polypeptide exhibiting higher activity for glutamic acid as an amino donor than that for L-alanine, and, having novel transaminase activity for generating (S)-1-benzyl-3-pyrrolidinone with high optical purity of 93% or more, a gene encoding the same, and a transformant expressing the gene at a high level are also provided herein.
    Type: Application
    Filed: September 28, 2011
    Publication date: August 1, 2013
    Applicant: KANEKA CORPORATION
    Inventors: Noriyuki Ito, Akiko Nishi, Shigeru Kawano, Yoshihiko Yasohara
  • Engineered plant cysteine proteases and their uses
    Publication number: 20130196413
    Abstract: The present invention relates to potato virus NIa protease variants or fragments thereof, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Application
    Filed: March 22, 2013
    Publication date: August 1, 2013
    Applicant: CENTOCOR ORTHO BIOTECH INC.
    Inventors: Ellen Chi, Michael Hunter, Ronald Swanson
  • BMP-7 Peptides and Methods of Use
    Publication number: 20130196909
    Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relate to methods of making and using the truncated growth factors.
    Type: Application
    Filed: March 24, 2011
    Publication date: August 1, 2013
    Applicant: LIFENET HEALTH
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
  • Polypeptides Having Cellobiohydrolase Activity And Polynucleotides Encoding Same
    Publication number: 20130198910
    Abstract: The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: August 30, 2011
    Publication date: August 1, 2013
    Applicants: NOVOYZMES A/S, NOVOZYMES, INC.
    Inventor: Nikolaj Spodsberg
  • CARRIER IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20130189283
    Abstract: Disclosed is an isolated immunoglobulin. Also disclosed are pharmaceutical compositions and medicaments comprising the immunoglobulin, isolated nucleic acid encoding it, vectors, host cells, useful in methods of making it. In some embodiments the immunoglobulin comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
    Type: Application
    Filed: September 22, 2011
    Publication date: July 25, 2013
    Applicant: AMGEN INC.
    Inventors: Kenneth W. Walker, Frederick W. Jacobsen, Taruna Arora
  • MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO
    Publication number: 20130189751
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
    Type: Application
    Filed: January 9, 2013
    Publication date: July 25, 2013
    Applicant: Genomatica, Inc.
    Inventors: Robert HASELBECK, John D. TRAWICK, Wei NIU, Anthony P. BURGARD
  • NOVEL GLUCOSE DEHYDROGENASE
    Publication number: 20130183716
    Abstract: The invention relates to a glucose dehydrogenase showing an NADP/NAD activity ratio, namely the value obtained by dividing the enzyme activity value obtained by using NADP as a coenzyme by the enzyme activity value obtained by using NAD as a coenzyme, of not lower than 300, to a gene coding therefor, and to a transformant harboring that gene. The enzyme of the invention is very high in NADP specificity and can be suitably used, for example, for NADPH production, for coenzyme regeneration in enzymatic reduction reactions, and in biosensors for glucose concentration measurements.
    Type: Application
    Filed: September 24, 2008
    Publication date: July 18, 2013
    Applicant: Kaneka Corporation
    Inventors: Shigeru Kawano, Yoshihiko Yasohara
  • BACTERIAL SURFACE DISPLAY AND SCREENING OF THIOETHER-BRIDGE-CONTAINING PEPTIDES
    Publication number: 20130184177
    Abstract: The invention relates to bacterial cell surface display of post-translationally modified heterologous proteins. Provided is an isolated nucleic acid construct encoding a proteinaceous substance comprising, from the N-terminus to the C-terminus, at least (a) an N-terminal a lantibiotic leader sequence; (b) an amino acid sequence of interest to be post-translationally modified to a dehydroresidue- or thioether-bridge containing polypeptide; (c) a hydrophilic cell-wall spanning domain; (d) a sortase recognition motif; (e) a hydrophobic membrane spanning domain and (f) a C-terminal charged membrane anchoring domain. Also provided is a Gram-positive host cell expressing the construct, as well as a library of host cells.
    Type: Application
    Filed: July 6, 2011
    Publication date: July 18, 2013
    Applicant: LanthioPep B.V.
    Inventor: Tjibbe Bosma
  • NOVEL GLYCOSYL HYDROLASE ENZYMES AND USES THEREOF
    Publication number: 20130177947
    Abstract: The present disclosure is generally directed to glycosyl hydrolase enzymes, compositions comprising such enzymes, and methods of using the enzymes and compositions, for example for the saccharification of cellulosic and hemicellulosic materials into sugars.
    Type: Application
    Filed: September 22, 2010
    Publication date: July 11, 2013
    Applicant: DANISCO US INC.
    Inventors: Benjamin Bower, Megan Yee Hsi, Thijs Kaper, Bradley R. Keleman, Suzanne E. Lantz, Edmund A. Larenas, Colin Mitchinson, Steven Kim, William D. Hitz, Mark Emptage, Keith Dumont Wing
  • Polypeptides Having Xylanase Activity And Polynucleotides Encoding Same
    Publication number: 20130180013
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: August 30, 2011
    Publication date: July 11, 2013
    Applicants: NOVOYZMES A/S, NOVOZYMES, INC.
    Inventor: Nikolaj Spodsberg
  • PROCESS FOR PRODUCING REVEROMYCIN A OR A SYNTHETIC INTERMEDIATE THEREOF, PROCESS FOR PRODUCING COMPOUNDS CONTAINING A SPIROKETAL RING AND NOVEL ANTINEOPLASTICS, FUNGICIDES AND THERAPEUTIC AGENTS FOR BONE DISORDERS
    Publication number: 20130177950
    Abstract: A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain.
    Type: Application
    Filed: August 30, 2011
    Publication date: July 11, 2013
    Applicant: RIKEN
    Inventors: Hiroyuki Osada, Shunji Takahashi, Makoto Kawatani, Yoshiyuki Sakaki, Atsushi Toyoda
  • NITRILASES
    Publication number: 20130177949
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: November 16, 2012
    Publication date: July 11, 2013
    Applicant: VERENIUM CORPORATION
    Inventors: VERENIUM CORPORATION, Darcy Madden
  • METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING DISEASES
    Publication number: 20130177566
    Abstract: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
    Type: Application
    Filed: November 6, 2012
    Publication date: July 11, 2013
    Applicant: CELERA CORPORATION
    Inventor: Celera Corporation
  • AMYLASE FROM NESTERENKONIA AND METHODS OF USE, THEREOF
    Publication number: 20130177964
    Abstract: Compositions and methods relating to an alpha-amylase enzyme obtained from Nesterenkonia and related spp. are described.
    Type: Application
    Filed: January 20, 2011
    Publication date: July 11, 2013
    Applicant: DANISCO US INC.
    Inventors: Brian E. Jones, Marc Kolkman
  • Methods of Improving the Introduction of DNA into Bacterial Cells
    Publication number: 20130177942
    Abstract: The present invention relates to methods of improving the introduction of DNA into bacterial host cells.
    Type: Application
    Filed: January 21, 2013
    Publication date: July 11, 2013
    Applicant: NOVOZYMES, INC.
    Inventor: Novozymes, Inc.
  • HIGHLY STABLE BETA-CLASS CARBONIC ANHYDRASES USEFUL IN CARBON CAPTURE SYSTEMS
    Publication number: 20130171718
    Abstract: The present disclosure relates to ?-class carbonic anhydrase polypeptides having improved properties including increased thermostability and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides formulations and uses of the polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering. Also provided are polynucleotides encoding the carbonic anhydrase polypeptides and host cells capable of expressing them.
    Type: Application
    Filed: December 20, 2012
    Publication date: July 4, 2013
    Applicant: CODEXIS, INC.
    Inventor: Codexis, Inc.
  • ENHANCED PRODUCTION OF ISOPRENE USING HOST CELLS HAVING DECREASED ISPA ACTIVITY
    Publication number: 20130164808
    Abstract: This invention relates to recombinant microorganisms capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, functional activity of the ispA gene is altered to reduce the production of isoprenoid molecules in recombinant cells engineered to produce isoprene or in cells otherwise susceptible to isoprenoid accumulation during fermentation. This decreased ispA gene functional activity enables enhanced synthesis of isoprene in a host microorganism.
    Type: Application
    Filed: December 21, 2012
    Publication date: June 27, 2013
    Applicant: DANISCO US INC.
    Inventor: Danisco US Inc.
  • BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXAMINE
    Publication number: 20130164794
    Abstract: The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
    Type: Application
    Filed: August 8, 2011
    Publication date: June 27, 2013
    Applicant: CODEXIS, INC.
    Inventors: John Limanto, Gregory Beutner, Brendan Grau, Jacob Janey, Artis Klapars, Eric Ashley, Hallena R. Strotman, Matthew D. Truppo, Gregory Hughes, Fabien L. Cabirol, Anupam Gohel, Steven J. Collier, Jack Liang, Marissa Mock, Emily Mundorff, Scott Novick, Derek Smith
  • Perhydrolase Variant Providing Improved Specific Activity In the Presence of Surfactant
    Publication number: 20130158118
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a variant of the Thermotoga maritima C277T acetyl xylan esterase is provided having an improved specific activity when producing peroxycarboxylic acids in the presence of an anionic surfactant. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 12, 2012
    Publication date: June 20, 2013
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventor: E. I. DU PONT DE NEMOURS AND COMPANY
  • Perhydrolase Variant Providing Improved Specific Activity In the Presence of Surfactant
    Publication number: 20130158116
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a variant of the Thermotoga maritima C277T acetyl xylan esterase is provided having an improved specific activity when producing peroxycarboxylic acids in the presence of an anionic surfactant. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 12, 2012
    Publication date: June 20, 2013
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventor: E. I. DU PONT DE NEMOURS AND COMPANY
  • L-MALATE PRODUCTION BY METABOLICALLY ENGINEERED ESCHERICHIA COLI
    Publication number: 20130157330
    Abstract: A process for the production of malic acid in commercially significant quantities from the carbon compounds by genetically modified bacterial strains (GMBS; also referred to as biocatalysts or genetically modified microorganisms) is disclosed. Microorganisms suitable for the production of malic acid can be cultured in one or two-step processes as disclosed herein.
    Type: Application
    Filed: September 1, 2011
    Publication date: June 20, 2013
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Xueli Zhang, Xuan Wang, Keelnatham T. Shanmugam, Lonnie O'Neal Ingram
  • Perhydrolase Variant Providing Improved Specific Activity In the Presence of Surfactant
    Publication number: 20130158115
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a variant of the Thermotoga maritima C277T acetyl xylan esterase is provided having an improved specific activity when producing peroxycarboxylic acids in the presence of an anionic surfactant. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 12, 2012
    Publication date: June 20, 2013
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventor: E. I. Du Pont De Nemours And Company
  • COLORIMETRIC AND FLUORESCENT PROTEINS
    Publication number: 20130157284
    Abstract: The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a variety of different wavelengths.
    Type: Application
    Filed: March 23, 2011
    Publication date: June 20, 2013
    Applicant: Board of Trustees of Michigan State University
    Inventors: Babak Borhan, James Geiger, Wenjing Wang, Chrysoula Vasileiou, Kin Sing Lee, Tetyana Berbasova
  • Perhydrolase Variant Providing Improved Specific Activity In the Presence of Surfactant
    Publication number: 20130158117
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a variant of the Thermotoga maritima C277T acetyl xylan esterase is provided having an improved specific activity when producing peroxycarboxylic acids in the presence of an anionic surfactant. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 12, 2012
    Publication date: June 20, 2013
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventor: E. I. DU PONT DE NEMOURS AND COMPANY
  • Polypeptides Having Lipase Activity And Polynucleotides Encoding Same
    Publication number: 20130152234
    Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: February 7, 2013
    Publication date: June 13, 2013
    Applicants: NOVOZYMES A/S, NOVOZYMES, INC.
    Inventors: Novozymes, Inc., Novozymes A/S
  • MICROORGANISMS AND METHODS FOR THE PRODUCTION OF CAPROLACTONE
    Publication number: 20130144029
    Abstract: The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.
    Type: Application
    Filed: November 2, 2012
    Publication date: June 6, 2013
    Inventors: Anthony P. Burgard, Robin E. Osterhout, Priti Pharkya, Mark J. Burk
  • PRODUCTION OF MONOTERPENES
    Publication number: 20130143291
    Abstract: The present invention relates to methods for producing monoterpenes, particularly tricyclene, by culturing microbial organisms that express a terpene synthase and optionally a prenyl transferase.
    Type: Application
    Filed: March 30, 2011
    Publication date: June 6, 2013
    Applicant: Codexis, Inc.
    Inventors: Robert McDaniel, Galit Meshulam-Simon, Oscar Alvizo, Xiyun Zhang
  • HUMANISED ANTIGEN BINDING PROTEINS TO MYOSTATIN6
    Publication number: 20130142788
    Abstract: The present invention relates to humanised antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such humanised antigen binding proteins in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.
    Type: Application
    Filed: June 2, 2011
    Publication date: June 6, 2013
    Inventors: Claire Ashman, Stephen Ashman, Paul Andrew Hamblin, Alan Peter Lewis, Martin Anibal Orecchia
  • Polypeptides Having Glucoamylase Activitiy and Polynucleotides Encoding Same
    Publication number: 20130137152
    Abstract: The present invention relates to isolated polypeptides having glucoamylase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains.
    Type: Application
    Filed: November 28, 2012
    Publication date: May 30, 2013
    Applicants: Novozymes North America, Inc., Novozymes A/S
    Inventors: Novozymes A/S, Novozymes North America, Inc.
  • Group B Streptococcus Polypeptides Nucleic Acids and Therapeutic Compositions and Vaccines Thereof
    Publication number: 20130129737
    Abstract: This invention provides an isolated nucleic acid encoding a polypeptide comprising amino acid sequences of a streptococcal matrix adhesion E (EmaE) polypeptide. Antibodies to the EmaE polypeptide and immunogenic fragments thereof are also provided. This invention provides pharmaceutical compositions, immunogenic compositions, vaccines, and diagnostic and therapeutic methods of use of the isolated polypeptide, antibodies thereto, and nucleic acids.
    Type: Application
    Filed: February 18, 2011
    Publication date: May 23, 2013
    Applicants: University of Utah Research Foundation, St. Jude Children's Research Hospital
    Inventors: Elisabeth Adderson, John Bohnsack
  • AMINO ACID SEQUENCES DIRECTED AGAINST GPCRS AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF GPCR-RELATED DISEASES AND DISORDERS
    Publication number: 20130130379
    Abstract: The present invention relates to amino acid sequences that are directed against G-protein coupled receptors (GPCRs), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
    Type: Application
    Filed: October 12, 2012
    Publication date: May 23, 2013
    Applicant: Ablynx N.V.
    Inventor: Ablynx N.V.
  • Polypeptides Having Beta-Glucosidase Activity, Beta-Xylosidase Activity, or Beta-Glucosidase and Beta-Xylosidase Activity and Polynucleotides Encoding Same
    Publication number: 20130130327
    Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: November 16, 2012
    Publication date: May 23, 2013
    Applicants: NOVOZYMES, INC., NOVOZYMES A/S
    Inventors: Novozymes A/S, Novozymes, Inc.
  • Polypeptides Having Beta-Glucosidase Activity, Beta-Xylosidase Activity, or Beta-Glucosidase and Beta-Xylosidase Activity and Polynucleotides Encoding Same
    Publication number: 20130130326
    Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: November 16, 2012
    Publication date: May 23, 2013
    Applicants: NOVOZYMES, INC., NOVOZYMES A/S
    Inventors: Novozymes A/S, Novozymes, Inc.
  • GENETICALLY ENGINEERED STRAIN WSJ-IA FOR PRODUCING ISOVALERYL SPIRAMYCIN I
    Publication number: 20130130324
    Abstract: A genetically engineered strain WSJ-IA for producing isovaleryl spiramycin I. Also provided is a method for preparing the strain, comprising the steps of: (a) constructing a recombinant plasmid comprising a double gene ist-acyB2; (b) transforming the plasmid into an isovaleryl spiramycin I—producing strain to obtain the strain WSJ-IA. The level of isovaleryl spiramycin I produced by fermentation of the strain WSJ-IA is increased 1.7 times and the fermentation potency thereof increased 4.14 times in comparison with the strain exclusively comprising a single gene ist.
    Type: Application
    Filed: July 21, 2011
    Publication date: May 23, 2013
    Applicant: SHEN YANG TONGLIAN GROUP CO., LTD.
    Inventors: Yiguang Wang, Yang Jiang, Shengwu Yang, Xiaofeng Zhao
  • Polypeptides Having Beta-Glucosidase Activity, Beta-Xylosidase Activity, or Beta-Glucosidase and Beta-Xylosidase Activity and Polynucleotides Encoding Same
    Publication number: 20130130325
    Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: November 16, 2012
    Publication date: May 23, 2013
    Applicants: NOVOZYMES, INC., NOVOZYMES A/S
    Inventors: Novozymes A/S, Novozymes, Inc.
  • METHOD FOR PRESERVING FOOD
    Publication number: 20130129732
    Abstract: Method for producing microbially stabilized foods characterized in that a food containing a dialkyl dicarbonate is treated by means of electroporation.
    Type: Application
    Filed: August 26, 2010
    Publication date: May 23, 2013
    Applicant: LANXESS Deutschland GmbH
    Inventors: Rebecca Lässker, Edwin Ritzer
  • NOVEL ANTIGEN BINDING PROTEINS
    Publication number: 20130123472
    Abstract: Antigen binding proteins, such as antibodies, which bind to human MAGE-A3, polynucleotides encoding such antigen binding proteins, and uses and manufacture thereof.
    Type: Application
    Filed: July 20, 2011
    Publication date: May 16, 2013
    Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventors: Alain Bergeron, Normand Blais, Remi M. Palmantier, Anthony Pilorget, Yves Fradet
  • Polypeptides Having Glucose Dehydrogenase Activity and Polynucleotides Encoding Same
    Publication number: 20130122149
    Abstract: The present invention relates to isolated polypeptides having glucose dehydrogenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: January 16, 2013
    Publication date: May 16, 2013
    Applicant: NOVOZYMES A/S
    Inventor: NOVOZYMES A/S
  • MICROORGANISMS AND METHODS FOR PRODUCING ALKENES
    Publication number: 20130122563
    Abstract: The invention provides non-naturally occurring microbial organisms containing an alkene pathway having at least one exogenous nucleic acid encoding an alkene pathway enzyme expressed in a sufficient amount to convert an alcohol to an alkene. The invention additionally provides methods of using such microbial organisms to produce an alkene, by culturing a non-naturally occurring microbial organism containing an alkene pathway as described herein under conditions and for a sufficient period of time to produce an alkene.
    Type: Application
    Filed: September 14, 2012
    Publication date: May 16, 2013
    Inventors: Mark J. Burk, Robin E. Osterhout
  • Polypeptides Having Lipase Activity And Polynucleotides Encoding Same
    Publication number: 20130123163
    Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: January 22, 2013
    Publication date: May 16, 2013
    Applicants: NOVOZYMES A/S, NOVOZYMES, INC.
    Inventors: Novozymes, Inc., Novozymes A/S
  • PRODUCTION OF ISOPRENE, ISOPRENOID PRECURSORS, AND ISOPRENOIDS USING ACETOACETYL-COA SYNTHASE
    Publication number: 20130122562
    Abstract: This invention relates to a recombinant microorganism capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, the acetoacetyl-CoA synthase gene encoding an enzyme capable of synthesizing acetoacetyl-CoA from malonyl-CoA and acetyl-CoA and one or more genes involved in isoprene biosynthesis that enables synthesis of isoprene from acetoacetyl-CoA are introduced into a host microorganism.
    Type: Application
    Filed: August 3, 2012
    Publication date: May 16, 2013
    Applicant: Danisco US Inc.
    Inventors: Ilana S. Aldor, Zachary Q. Beck, Michael C. Miller, Caroline M. Peres
  • EPITOPE TAG FOR AFFINITY-BASED APPLICATIONS
    Publication number: 20130115635
    Abstract: Described is an epitope tag useful in affinity-based applications. The invention further includes fusion proteins, methods for preparing fusion proteins, nucleic acid molecules encoding these fusion proteins and recombinant host cells that contain these nucleic acid molecules. The invention also relates to nanobodies and other affinity ligands specifically recognizing the epitope tag, and uses thereof in affinity-based applications.
    Type: Application
    Filed: May 25, 2011
    Publication date: May 9, 2013
    Inventors: Els Pardon, Jan Steyaert, Lode Wyns
  • ENONE REDUCTASES
    Publication number: 20130115663
    Abstract: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
    Type: Application
    Filed: October 23, 2012
    Publication date: May 9, 2013
    Applicant: CODEXIS, INC.
    Inventor: Codexis, Inc.
  • Novel Substitution Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression System
    Publication number: 20130117872
    Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
    Type: Application
    Filed: September 14, 2012
    Publication date: May 9, 2013
    Inventors: Subba Reddy PALLI, Mohan Basavaraju Kumar, Dean Ervin Cress, Ted Tsutomu Fujimoto
  • FUNGAL PEROXYGENASES AND METHODS OF APPLICATION
    Publication number: 20130115662
    Abstract: The invention relates to polypeptides having peroxygenase activity and compositions comprising such polypeptides, their encoding polynucleotides, expression vectors and recombinant host cells comprising such polynucleotides or vectors, methods of producing the polypeptides, as well as methods of application and uses thereof, including a process for enzymatic, regioselective oxygenation of N-heterocycles of the general formula (I) to the corresponding N-oxides of the formula (II), by converting N-heterocycles of the formula (I) with a peroxidase polypeptide in the presence of at least one oxidizing agent in a one-stage reaction process.
    Type: Application
    Filed: December 20, 2012
    Publication date: May 9, 2013
    Applicant: NOVOZYMES A/S
    Inventor: Novozymes A/S
  • KETOREDUCTASE MUTANT
    Publication number: 20130116416
    Abstract: Disclosed are a ketoreductase mutant which can be used for an efficient production of daunorubicin derivatives, a DNA encoding the mutant, a transformant prepared by introducing the DNA thereinto to produce a daunorubicin derivative, and a process of producing a daunorubicin derivative using the transformant. The ketoreductase mutant has an amino acid sequence in which one amino acid residue or two or more amino acid residues selected from the group consisting of amino acids located at positions corresponding to the 42nd, 149th, 153rd, 270th, and 306th amino acids in the amino acid sequence of a ketoreductase (EvaE) from a chlororemomycin-producing bacterium (Amycolatopsis orientalis) are substituted with another amino acid residues.
    Type: Application
    Filed: May 21, 2010
    Publication date: May 9, 2013
    Applicant: MEIJI SEIKA PHARMA, CO., LTD.
    Inventors: Fusuke Mazuka, Takayoshi Fukushima, Naomi Sumida, Koji Yanai
  • TELOMERASE ACTIVITY INHIBITING PEPTIDE AND MANUFACTURING METHOD AND APPLICATION THEREOF
    Publication number: 20130108654
    Abstract: The present invention provides a telomerase activity inhibiting polypeptide. The expression of the polypeptide in tumor cells can inhibit significantly tumor cell telomerase activity, tumor cell growth, and lead to the death of such cells. The present invention further provides a preparation method for the polypeptide and an application thereof in targeted treatments of tumors.
    Type: Application
    Filed: July 4, 2011
    Publication date: May 2, 2013
    Applicant: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CAS
    Inventors: Mujun Zhao, Jian Feng, Guoyuan Chen, Jing Zhao, Guangming Chen, Liang Da, Zaiping Li