Bacteria Or Actinomycetales; Media Therefor Patents (Class 435/252.1)
  • Patent number: 10350250
    Abstract: Provided herein are compositions and methods for the treatment or prevention of pathogenic infections.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: July 16, 2019
    Assignee: Vedanta Biosciences, Inc.
    Inventors: Jessica Schneider, Yun-Gi Kim, Bernat Olle, Shilpa Reddy, Jason Norman, Juan Patarroyo
  • Patent number: 10316299
    Abstract: The present invention relates to beta-ketoacyl ACP synthase genes of the KASI/KASIV type and proteins encoded by these genes. The genes can be included in nucleic acid constructs, vectors or host cells. Expression of the gene products can alter the fatty acid profile of host cells. The KAS genes can be combined with a FATA or FATB thioesterase gene to create a cell that produces an increased amount of C8-C16 fatty acids. Suitable host cells include plastidic cells of plants or microalgae. Oleaginous microalga host cells with the new genes are disclosed.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: June 11, 2019
    Assignee: CORBION BIOTECH, INC.
    Inventors: David Davis, George N. Rudenko, Aravind Somanchi, Jason Casolari, Scott Franklin, Aren Ewing
  • Patent number: 10316339
    Abstract: The present invention relates to a polypeptide having a resistant to feedback inhibition by methionine and an activity of homoserine O-succinyltransferase, a O-succinyl homoserine-producing microorganism expressing the polypeptide, and a method for producing O-succinyl homoserine using the same.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: June 11, 2019
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Su Jin Choi, So Young Kim, Chang Il Seo, Yong Uk Shin, Young Lyeol Yang, Hye Won Um, Hye Min Park, Sung Hoo Jhon, Byung Hoon Jung
  • Patent number: 10155015
    Abstract: The present disclosure is directed to methods of administering and compositions comprising Lactobacillus plantarum CECT 7478, Lactobacillus plantarum CECT 7485, and Pediococcus acidilactici CECT 7483 or a mutant or variant thereof. The compositions and methods are useful in the probiotic treatment of bowel diseases or conditions such as Inflammatory Bowel Disease, Irritable Bowel Syndrome, and abdominal distension and bloating.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: December 18, 2018
    Assignee: AB-Biotics S.A.
    Inventors: Jordi Espadaler Mazo, Jordi Cune Castellana
  • Patent number: 10144978
    Abstract: Probiotic Bifidobacterium strain AH1714 is significantly immunomodulatory following oral consumption. The strain is useful as an immunomodulatory biotherapeutic agent.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: December 4, 2018
    Assignee: Alimentary Health Ltd.
    Inventors: Liam O'Mahony, Barry Kiely, John Francis Cryan, Timothy Dinan, Eileen Frances Murphy
  • Patent number: 10138459
    Abstract: The invention relates to a bacterial strain belonging to the genus Rhodococcus which is a producer of a nitrile hydratase. The invention also relates to a method for producing acrylamide by hydration of acrylonitrile using a biomass of the bacterial strain and to a method of culturing the bacterial strain.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: November 27, 2018
    Assignee: Kemira Oyj
    Inventors: Sergey Vladimirovich Kozulin, Tatiana Nicolaevna Kozulina, Alexey Sergeevich Kozulin
  • Patent number: 10130098
    Abstract: The subject invention pertains to methods for reducing the incidence or severity of citrus greening in desirable plants, such as orange trees, grapefruit trees, lime trees, lemon trees and the like.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: November 20, 2018
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventor: Donald L. Hopkins
  • Patent number: 10131689
    Abstract: Provided is a separation and purification method for vancomycin hydrochloride of high purity. The method comprises the following steps: (1) obtaining a vancomycin hydrochloride solution from a crude vancomycin product by ion exchange chromatography and obtaining a concentrate by nanofiltration desalination and concentration; (2) adjusting the concentrate with a hydrochloric acid solution and then performing a column chromatography using a reverse chromatography column for the adjusted concentrate; (3) collecting the chromatographic solution of vancomycin to obtain a mixed chromatographic solution; (4) adjusting the mixed chromatographic solution, and separating the solution and the salts by nanofiltration desalination and concentration to obtain a concentrate; and (5) obtaining a vancomycin dry powder with a chromatographic purity of up to 99% and a pure white appearance by dehydrating and drying the concentrate of step (4), or by solvent crystallization or salting-out crystallization.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: November 20, 2018
    Assignee: Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Enmin Li, Yiyun Zhuang, Jue Wang, Xinqiang Sun, Xuejun Lao, Biwang Jiang
  • Patent number: 10105450
    Abstract: An isolated promoter sequence comprising a nucleic acid of between 600 and 1700 nucleotides in length having at least 90% identity to SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, or SEQ ID NO:7.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: October 23, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Edgardo Rodriguez, Alejandro Mas Monteys
  • Patent number: 10100338
    Abstract: A process is provided for fermentation of syngas that is effective for reducing conductivity and providing an alcohol STY of about 10 g ethanol/(L·day). The process includes introducing the syngas into a reactor vessel and providing a nitrogen feed rate to the reactor vessel of about 100 mg or more nitrogen/gram of cells produced. Fermentation of the syngas is effective for providing a fermentation medium having an average conductivity of about 16 mS/cm or less and an STY of 10 g ethanol/(L·day) or more.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: October 16, 2018
    Inventors: Syrona Scott, Song Liu, Ching-Whan Ko
  • Patent number: 10087474
    Abstract: A fed-batch fermentation method is for production of bacteriochlorophyll a (Bchla) from Rhodovulum sulfidophilum. The growth medium contains an inorganic nitrogen compound as a nitrogen source. During fermentation, the growth medium is supplemented with a succinate carbon source, an inorganic compound nitrogen source and a phosphorous source from external reservoirs connected to the fermenter vessel. After completion of the fermentation, Bchla is recovered from the separated cells.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: October 2, 2018
    Assignee: TOOKAD IP SARL
    Inventors: Doron Eren, Nitsa Mazor
  • Patent number: 10076119
    Abstract: The present invention relates to pesticidal mixtures comprising one biological compound and at least one fungicidal, insecticidal or plant growth regulating compound as defined herein and respective agricultural uses thereof.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: September 18, 2018
    Assignee: BASF Corporation
    Inventors: Lutz Brahm, Burghard Liebmann, Ronald Wilhelm, Markus Gewehr
  • Patent number: 10047381
    Abstract: There is described a method for producing 3-hydroxypropanal, the method comprising: culturing an Acetobacter lovaniensis bacterium in a growth medium containing phosphate at a level which is more than 1 g/liter and nitrate at a level which is more than 0.1 g/liter, wherein culturing of the bacterium produces the 3-hydroxypropanal. The 3-hydroxypropanal can be separated from the growth medium or, when the microorganism has converted some or all of the 3-hydroxypropanal to 3-hydroxypropionic acid and/or a 3-hydroxypropionate ester, it may be separated as 3-hydroxypropionic acid or a 3-hydroxypropionate ester. The separated product can be converted into other chemicals such as an ester of 3-hydroxypropionic acid, 3-hydroxypropionic acid, 3 -hydroxypropionate salts (including ammonium, sodium and calcium 3-hydroxypropionate), acrylic acid, acrylates, acrylamide, acrylonitrile, acrolein and 1,3 propanediol.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: August 14, 2018
    Assignee: VERDANT BIOPRODUCTS LIMITED
    Inventor: Irene Finnegan
  • Patent number: 10023843
    Abstract: The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts into eukaryotic host cells. The invention provides artificial endosymbionts that introduce a phenotype to host cells that is maintained in daughter cells. The invention additionally provides eukaryotic host cells containing magnetotactic bacteria.
    Type: Grant
    Filed: May 13, 2017
    Date of Patent: July 17, 2018
    Assignee: Bell Biosystems, Inc.
    Inventors: Caleb B. Bell, III, Alexey Bazarov
  • Patent number: 10011811
    Abstract: Described is a device comprising an anchor, a tray including a well adapted to receive the anchor, and a cover adapted to engage the tray and cover the well. The device may be used to form a membrane-cell matrix having a substantially uniform distribution of the cells on the membrane in at least two dimensions.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: July 3, 2018
    Assignee: Vericel Corporation
    Inventors: Yongzhong Wang, Christopher Kelly, Stephen Rapko, Frank Quinno, Barbara Seymour
  • Patent number: 9993003
    Abstract: The present invention relates to pesticidal mixtures comprising one biological compound and at least one fungicidal, insecticidal or plant growth regulating compound as defined herein and respective agricultural uses thereof.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: June 12, 2018
    Assignee: BASF Corporation
    Inventors: Lutz Brahm, Burghard Liebmann, Ronald Wilhelm, Markus Gewehr
  • Patent number: 9976127
    Abstract: The present invention concerns variant proteins of manganese superoxide dismutase (MnSOD) and uses thereof. In particular, the invention concerns a short variant of recombinant MnSOD, and uses thereof for treating or preventing tumors, as well as for treating or preventing diseases with an etiology relating to an excess of free radicals.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: May 22, 2018
    Inventor: Aldo Mancini
  • Patent number: 9975816
    Abstract: According to the present invention new isolates of bacterial strains have been shown to possess unique properties. These bacterial strains are plant growth-promoting rhizobacterium (PGPR), posses an enhanced competitive advantage at colonizing leguminous plants, and enhance the overall performance of leguminous plant growth. Further still, the present invention discloses a novel method for screening and selecting bacterial strains having the aforementioned beneficial characteristics.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: May 22, 2018
    Assignee: NOVOZYMES BIOLOGICALS, INC.
    Inventors: Yaowei Kang, Shawn Semones, Jessica Smith, Kristi Woods
  • Patent number: 9969990
    Abstract: The present invention relates to beta-ketoacyl ACP synthase genes of the KASI/KASIV type and proteins encoded by these genes. The genes can be included in nucleic acid constructs, vectors or host cells. Expression of the gene products can alter the fatty acid profile of host cells. The KAS genes can be combined with a FATA or FATB thioesterase gene to create a cell that produces an increased amount of C8-C16 fatty acids. Suitable host cells include plastidic cells of plants or microalgae. Oleaginous microalga host cells with the new genes are disclosed.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: May 15, 2018
    Assignee: Corbion Biotech, Inc.
    Inventors: David Davis, George Rudenko, Aravind Somanchi, Jason Casolari, Scott Franklin, Aren Ewing
  • Patent number: 9926525
    Abstract: The present invention relates to systems and methods for optimising the usage of laboratory and cell culturing space for cell culture and biomanufacturing. The invention provides a system and method that can be used to provide a plurality of workstations and/or storage bays for bioreactors in cell culturing and/or biomanufacturing facilities.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 27, 2018
    Assignee: GE Healthcare UK Limited
    Inventors: Christopher George Norey, Michelle Louise Janas, Anthony Patterson, Adrian Crawley
  • Patent number: 9834747
    Abstract: In exemplary implementations, transplantation of nucleic acids into cells occurs in microfluidic chambers. The nucleic acids may be large nucleic acid molecules with more than 100 kbp. In some cases, the microfluidic chambers have only one orifice that opens to a flow channel. In some cases, flow through a microfluidic chamber temporarily ceases due to closing one or more valves. Transplantation occurs during a period in which the contents of the chambers are shielded from shear forces. Diffusion, centrifugation, suction from a vacuum channel, or dead-end loading may be used to move cells or buffers into the chambers.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: December 5, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Andreas Mershin, James Pelletier, Neil Gershenfeld, John Glass, Elizabeth Strychalski
  • Patent number: 9803196
    Abstract: Compositions and methods which inhibit the expression of the TMEM92 gene or which inhibits the function of die TMEM92 protein can be used for treating, diagnosing and monitoring disease, for example cancer.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: October 31, 2017
    Assignee: HOX Therapeutics Limited
    Inventor: Richard Morgan
  • Patent number: 9790463
    Abstract: The disclosure provides a culturing medium for culturing a bacterium of genus Tepidimonas, including: a carbon source which is an organic acid, selected from a group consisting of acetate, lactate and butyrate; a nitrogen source selected from a group consisting of ammonium sulfate ((NH4)2SO4), ammonium nitrate (NH4NO3), ammonium chloride (NH4Cl) and urea; phosphate; magnesium chloride (MgCl2); yeast extract; and trace elements.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: October 17, 2017
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Yin-Lung Han, Tai-Rong Guo, Jo-Shu Chang, Yung-Chong Lou, Chieh-Lun Cheng, Wan-Ju Yu, Chih-Hsi Liu
  • Patent number: 9782446
    Abstract: Disclosed are novel Lactobacillus plantarum strains as well as a composition containing the novel Lactobacillus plantarum strains or a culture thereof.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: October 10, 2017
    Assignee: AMOREPACIFIC CORPORATION
    Inventors: Il Young Kwack, Se Jin You, Tae-Hun Park, Bum Jin Lee, Kye Ho Shin, Jin Oh Chung, Jun Cheol Cho
  • Patent number: 9777061
    Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: October 3, 2017
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Hilmar Erhard Ebersbach, Thomas Huber, Julia Jascur, Celeste Richardson, Reshma Singh, Huijuan Song, Qilong Wu, Jiquan Zhang
  • Patent number: 9772338
    Abstract: The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: September 26, 2017
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Abuzar Kabir, Kenneth G. Furton
  • Patent number: 9713333
    Abstract: A product for treating and/or preventing diseases such as basal stem rot caused by Ganoderma infection, in plants such as oil palms, comprising a growth medium used to grow Pseudomonas fluorescens bacteria, said growth medium including palm oil mill effluent.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: July 25, 2017
    Assignee: Agribolics Technology Sdn. Bhd.
    Inventors: Siew Fan Loh, Mohd Amid Fursan bin Abdullah
  • Patent number: 9663532
    Abstract: Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections are provided. Methods are provided for the production of artemisinin derivatives via functionalization of positions C7 and C6a, and optionally, in conjunction with modifications at positions C10 and C9, via chemoenzymatic methods. Recombinant cytochrome P450 polypeptides are also provided for use in the methods. The artemisinin derivatives can be used for the treatment of malaria and other parasitic infections, alone or in combination with other antiparasitic drugs.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: May 30, 2017
    Assignee: University of Rochester
    Inventors: Rudi Fasan, Kai-Dong Zhang
  • Patent number: 9657275
    Abstract: The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts into eukaryotic host cells. The invention provides artificial endosymbionts that introduce a phenotype to host cells that is maintained in daughter cells. The invention additionally provides eukaryotic host cells containing magnetotactic bacteria.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: May 23, 2017
    Assignee: Bell Biosystems, Inc.
    Inventors: Caleb Bell, III, Alexey Bazarov
  • Patent number: 9624465
    Abstract: The invention relates to compositions containing Bacillus sp., optionally with magnetite, useful in methods for collecting algae. The invention also relates to methods for collecting algae by contacting algae and bare maghemite and compositions thereof.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: April 18, 2017
    Assignee: University of Maryland Center for Environmental Science
    Inventors: Ryan J. Powell, Russell T. Hill
  • Patent number: 9593353
    Abstract: The present invention relates to a polypeptide having a resistant to feedback inhibition by methionine and an activity of homoserine O-succinyltransferase, a O-succinyl homoserine-producing microorganism expressing the polypeptide, and a method for producing O-succinyl homoserine using the same.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: March 14, 2017
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Su Jin Choi, So Young Kim, Chang Il Seo, Yong Uk Shin, Young Lyeol Yang, Hye Won Um, Hye Min Park, Sung Hoo Jhon, Byung Hoon Jung
  • Patent number: 9422579
    Abstract: Described is a process for the conversion of halophytic plant biomass containing saline organic solids into biogas through anaerobic digestion. Operation of the process with saline (e.g., seawater) as liquid media under the method conditions taught leads to biological conversion of the organic matter into biogas. Additionally described is a method for pretreatment of the biomass under mild physicochemical conditions to increase the bioavailable fraction of the biomass for conversion.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: August 23, 2016
    Assignee: Masdar Institute of Science and Technology
    Inventors: Jorge Rodriguez, Joao Marcus Uratani
  • Patent number: 9394207
    Abstract: The invention relates to fertilizer compositions comprising a carbon source and a source of nitrogen. Carbon is in form that can be readily up-taken by soil bacteria. The invention also relates to a method for manufacturing the fertilizer, a method for fertilizing soil and uses of said fertilizer. Use of the fertilizer promotes uptake of endogenous soil nutrient resources by plant.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: July 19, 2016
    Assignee: Biokasvu Oy
    Inventors: Keijo Lehtonen, Juha Tilkanen
  • Patent number: 9382166
    Abstract: A plant nutrition composition including long organic fibers having nitrogen, phosphorus and potassium available for plants, in combination with organic substratum providing pH balancing in the range of about 6.0 to about 7.0. The long fibers may be the end product of slow, heat-agitated anaerobic digestion of manure. Combined with the fibers are substratum such as pine bark composted for a duration in the range of between about 9 months and about 12 months.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: July 5, 2016
    Assignee: Magic Dirt LLC
    Inventors: Walter Robert Joblin, Jr., Richard Theodore Sniegocki
  • Patent number: 9322040
    Abstract: The invention discloses a Pseudonocardia sp. and a method for preparing Deoxynyboquinone by utilizing the same. Pseudonocardia sp. SCSIO 01299 was collected in China Center for Type Culture Collection (CCTCC) (Address: Wuhan University, Wuhan City, China) with the collection number of CCTCC NO: M 2011255 on Jul. 18, 2011. The Pseudonocardia sp. SCSIO 01299 can produce antibiotic Deoxynyboquinone, so that the Pseudonocardia sp. SCSIO 01299 can be utilized for preparing Deoxynyboquinone and a new way is provided for producing antibiotic Deoxynyboquinone with anti-tumor activity.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: April 26, 2016
    Assignee: SOUTH CHINA SEA INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Si Zhang, Changsheng Zhang, Xinpeng Tian, Sumei Li, Wenjun Zhang, Haibo Zhang, Guangtao Zhang, Hao Yin, Jianhua Ju
  • Patent number: 9267161
    Abstract: The present invention relates to Corynebacterium sp. that is transformed with an Escherichia sp.-derived fructokinase gene to express fructokinase showing a sufficient activity of converting fructose into fructose-6-phosphate, thereby preventing unnecessary energy consumption, and a method for producing L-amino acids using the strain. The transformed Corynebacterium sp. of the present invention is able to express fructokinase from the Escherichia-derived fructokinase gene to prevent unnecessary energy consumption during fructose metabolism, leading to more cost-effective production of L-amino acids. Therefore, it can be widely used for the effective production of L-amino acids.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: February 23, 2016
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Hyun Won Bae, Hyung Joon Kim, Jun Ok Moon, Jae Woo Jang, Jong Chul Kim, Tae Han Kim, Jin Suck Sung, Kyung Han Lee, Dae Cheol Kim, Hyo Jin Kim, Hyun Ae Bae, Sang Jo Lim
  • Patent number: 9253979
    Abstract: Methods of controlling insects include applying at least one spinosyn compound to a locus of a neonicotinoid-resistant insect, such as a strain of Drosophila melanogaster resistant to a neonicotinoid compound. The spinosyn compound may be a mixture of spinosyn A and spinosyn D. The spinosyn compound may cause up to approximately ten times increased mortality in the neonicotinoid-resistant insect compared to an insect susceptible to a neonicotinoid compound.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: February 9, 2016
    Assignee: Dow AgroSciences LLC
    Inventors: Thomas C. Sparks, Gerald B. Watson
  • Patent number: 9217133
    Abstract: This invention relates to a composition suitable for use in the prevention of opportunistic infections in immune-compromised individuals comprising a probiotic Bifidobacterium lactis, Bifidobacterium infantis, Bifidobacterium breve or Bifidobacterium longum and a fucosylated oligosaccharide selected from the group comprising 2?-fucosyllactose, 3?fucosyllactose, difucosyllactose, lacto-N-fucopentaose, lacto-N-fucohexaose, fucosyllacto-N-hexaose and fucosyllacto-N-neohexaose. The invention further extends to the use of such a composition in the prevention of opportunistic infections in immune-compromised individuals.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: December 22, 2015
    Assignee: Nestec S.A.
    Inventor: Norbert Sprenger
  • Patent number: 9196760
    Abstract: A method for producing a film, the method comprising melting a layer of precursor particles on a substrate until at least a portion of the melted particles are planarized and merged to produce the film. The invention is also directed to a method for producing a photovoltaic film, the method comprising depositing particles having a photovoltaic or other property onto a substrate, and affixing the particles to the substrate, wherein the particles may or may not be subsequently melted. Also described herein are films produced by these methods, methods for producing a patterned film on a substrate, and methods for producing a multilayer structure.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: November 24, 2015
    Assignee: UT-BATTELLE, LLC
    Inventors: Chad E. Duty, Charlee J C Bennett, Ji-Won Moon, Tommy J. Phelps, Craig A. Blue, Quanqin Dai, Michael Z. Hu, Ilia N. Ivanov, Gerald E. Jellison, Jr., Lonnie J. Love, Ronald D. Ott, Chad M. Parish, Steven Walker
  • Patent number: 9145543
    Abstract: The subject of the present invention is a process for producing adherent cells comprising: a. introducing a suspension of adherent cells into a culture vessel containing microcarriers in a culture medium; b. amplifying the cells by performing a plurality of cell passages in the same culture vessel wherein each cell passage subsequent to the first is carried out: i) by using all or part of the cells produced during the previous cell passage after having subjected the cells to enzyme treatment to detach the cells from the microcarriers, and ii) by introducing culture medium and an increasing amount of microcarriers into the culture medium; and c. harvesting the cells produced during the last cell passage, optionally after having subjected the cells to enzyme treatment to detach cells from microcarriers. The invention also relates to the implementation of this process for the production of biological agents, serving in particular to prepare vaccines or drugs.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: September 29, 2015
    Assignee: Sanofi Pasteur SA
    Inventors: Eric Calvosa, Nicolas Seve
  • Patent number: 9057070
    Abstract: Provided is an isolated B. fragilis bacterial cell producing a native capsular polysaccharide A (PSA), wherein the cell is incapable of producing capsular polysaccharides PSB, PSC, PSD, PSE, PSF, PSG, and PSH because the cell's biosynthetic genes for native capsular polysaccharides PSB, PSC, PSD, PSE, PSF, PSG, and PSH have been deleted from the cell's genome. The isolated or wild type B. fragilis cell, or an extract obtained from said B. fragilis cell, can be used to treat individuals with inflammation.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: June 16, 2015
    Assignees: California Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Sarkis K. Mazmanian, Sung-Eun Lee, Dennis L. Kasper
  • Publication number: 20150147792
    Abstract: A method of making a C4 diacid from a sugar source by fermentation with a microorganism is described that includes supplementing the fermentation medium with relatively low amounts of betaine. The use of betaine can substantially reduce or even completely eliminate the need for complex nutrient source such as yeast extract, and eliminate a need for vitamins such as biotin, while maintaining a high level of production of the C4 diacid from a simplified sugar based media. The use of betaine improves yield from sugar, final titer, and rate of production per hour. The method is particularly suitable for microorganisms that otherwise display a dependence on yeast extract for high productivity, more particularly for any bacteria, and most particularly for the production of succinic acid from the bacterium Actinobacillus succinogenes. An improved strain of A succinogenes is also described, having a mutation in a betaine transporter that improves C4 diacid production in the presence of betaine.
    Type: Application
    Filed: June 27, 2013
    Publication date: May 28, 2015
    Inventor: Jill Morriss
  • Publication number: 20150140656
    Abstract: The present invention is a method of freezing cells comprising the steps of incubating said cells in a solution comprising a cryoprotective agent, concentrating the cells resulting from the previous step withdrawing the eluent essentially free of cells, and freezing the resulting concentrated cells. The cells frozen by the invention's method render a high post-thawing viability, reduce cryoprotectant related toxic events and promote cells life in a suspension state after thawing. The invention also comprises the container comprising the frozen cells.
    Type: Application
    Filed: September 16, 2014
    Publication date: May 21, 2015
    Inventors: Roberto HERNAN IZQUIERDO, Natalia Gallot Escobal, Antonio Cruz Pacheco
  • Publication number: 20150139955
    Abstract: A peptide dimer comprising a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and a peptide consisting of any one of the amino acid sequences of SEQ ID NOS: 2 to 4, wherein the peptide consisting of the amino acid sequence of SEQ ID NO: 1 and the peptide consisting of any one of the amino acid sequences of SEQ ID NOS: 2 to 4 are bound through a disulfide bond between a cysteine residue of each peptide is used as an active ingredient of an agent for promoting proliferation of one or more bacterium selected from the group consisting of Bifidobacterium infantis and Bifidobacterium breve.
    Type: Application
    Filed: August 24, 2012
    Publication date: May 21, 2015
    Applicant: MORINAGA MILK INDUSTRY CO., LTD.
    Inventors: Hirotsugu Oda, Koji Yamauchi, Takumi Sato, Kanetada Shimizu
  • Publication number: 20150140171
    Abstract: The present invention is related to the field of reddening of food products. In particular the present invention relates to a two-phase fermentation method for boosting the nitrate reductase activity of Staphylococcus strains with nitrate reductase activity comprising a first aerobic phase in the absence of nitrate and a second anaerobic or oxygen limited phase with continuous nitrate feeding and use of the Staphylococcus strains for reddening of most products.
    Type: Application
    Filed: June 14, 2013
    Publication date: May 21, 2015
    Applicant: Chr. Hansen A/S
    Inventors: Carina Nissen, Tim Martin Seibert
  • Patent number: 9034618
    Abstract: The present invention relates to methods for sustaining microorganism culture in a syngas fermentation reactor in decreased concentration or absence of various substrates comprising: adding carbon dioxide and optionally alcohol; maintaining free acetic acid concentrations; and performing the above mentioned steps within specified time.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: May 19, 2015
    Assignee: INEOS BIO SA
    Inventors: Stephen S. Adams, Syrona Scott, Ching-Whan Ko
  • Publication number: 20150132264
    Abstract: A first aspect of the invention relates to the bacterial species Roseburia hominis for use in: regulating the immune system of a subject treating an immune disorder; treating an intestinal disorder; improving intestinal microbiota; regulating the innate immune system of a subject; regulating the adaptive immune system of a subject; regulating appetite in a subject; promoting Tregs and immune tolerance; promoting gut health in a subject; and/or maintaining immune homeostasis in a subject. Further aspects of the invention relate to compositions comprising Roseburia hominis.
    Type: Application
    Filed: October 8, 2012
    Publication date: May 14, 2015
    Applicant: GT BIOLOGICS LTD
    Inventors: Denise Kelly, Imke Mulder
  • Publication number: 20150132740
    Abstract: A concentration agent for microorganisms is provided that contains both lanthanum and carbonate. Additionally, articles that include the concentration agent and methods of concentrating a microorganism using the concentration agent are provided.
    Type: Application
    Filed: May 23, 2013
    Publication date: May 14, 2015
    Inventors: Manjiri T. Kshirsagar, Evan Koon Lun Yuuji Hajime, Andrew W. Rabins
  • Publication number: 20150132741
    Abstract: The present invention relates to compounds for use in the control of extraction procedures, particular in connection with nucleic acid material for use in PCR and more preferably real time PCR (quantitative PCR), The extraction control according to the present invention is based on non-pathogenic bacterial material which can be produced at low cost, in large quantities and which has good stability.
    Type: Application
    Filed: May 17, 2013
    Publication date: May 14, 2015
    Applicant: VELA OPERATIONS PTE. LTD.
    Inventors: Ann Lee Ling, Xi Li
  • Publication number: 20150132827
    Abstract: A centrifuge tube fermenter for culturing cells in a nutrient medium wherein the centrifuge tube fermenter is comprised of a top end, a bottom end, a vertical cylindrical outer wall positioned between the top end and the bottom end, and an inner wall positioned inside the outer wall, the bottom end further comprised of a plurality of baffles which protrude from inner wall toward a theoretical center of the vertical cylindrical outer wall terminating in a conical tip.
    Type: Application
    Filed: November 5, 2014
    Publication date: May 14, 2015
    Inventor: Andre Simoes