Mixed Culture Patents (Class 435/252.4)
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Patent number: 7429477Abstract: Fungal/bacterial antagonist combinations, a seed coated with one of the combinations and a plant protected from plant pathogens by one of the combinations. The invention is also a fungal/bacterial antagonist combination comprising a Trichoderma virens fungal antagonist and a Bacillus subtilis var. amyloliquefaciens (Bacillus amyloliquefaciens) bacterial antagonist and its use for controlling plant pathogens as a biocontrol agent, bio-pesticide or bio-fungicide. The invention also finds utility as a fungal/bacterial antagonist combination applied to the seed, stalk or leaf that results in an increase in plant yield. Control of early and late season stalk and root rot caused by fungi such as Fusarium, Phythium, Phytophthora and Penicillium in tomatoes, peppers, turf grass, soybeans, sunflower, wheat and corn is achieved.Type: GrantFiled: September 13, 2004Date of Patent: September 30, 2008Inventor: Thomas D. Johnson
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Patent number: 7425440Abstract: A culture flask 10 comprises two or more internal chambers 18-21 defining a plurality of parallel surfaces of different sizes and means for fluid communication 24 between the chambers 18-20.Type: GrantFiled: June 9, 2004Date of Patent: September 16, 2008Assignee: The Automation Partnership (Cambridge) LimitedInventors: David S Malinge, Richard Wales, Peter Esser, Stephen Guy
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Publication number: 20080213865Abstract: A compound microbial preparation includes multiple single microbial series, hormones produced from each of those multiple single microbial series separately cultivated, and hormones produced from cross cultivation among those multiple single microbial series to be applied in modifying soil quality, activating soil, effectively degrading soil pollution, and helping growth of crops.Type: ApplicationFiled: March 1, 2007Publication date: September 4, 2008Inventor: Wen-Hsiung Lai
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Patent number: 7416879Abstract: An isolated microbial consortium is described that includes a first microbial consortium having Thermacetogenium phaeum to metabolize a complex hydrocarbon substrate into metabolic products comprising an acetate compound. The consortium also includes a second microbial consortium having a methanogen to convert the acetate compound into a final product that includes methane. Also, a method of increasing production of materials with enhanced hydrogen content. The method includes isolating Thermacetogenium phaeum from geologic formation water, culturing the isolated Thermacetogenium phaeum to increase the Thermacetogenium phaeum population, and introducing a consortium of the cultured Thermacetogenium phaeum, which may include spores of Thermacetogenium phaeum, into a hydrocarbon formation containing a complex hydrocarbon substrate.Type: GrantFiled: January 11, 2006Date of Patent: August 26, 2008Assignee: LUCA Technologies, Inc.Inventors: Robert S. Pfeiffer, Glenn A. Ulrich, Gary Vanzin
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Patent number: 7410791Abstract: The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).Type: GrantFiled: January 13, 2006Date of Patent: August 12, 2008Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Rahul Singhvi, Amit Kumar, George M. Whitesides, Donald E. Ingber, Gabriel P. Lopez, Daniel I. C. Wang, Gregory Stephanopoulos
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Patent number: 7407794Abstract: The present invention relates to the use of Ulocladium oudemansii as a biological control agent. Processes and compositions for the biological control of Botrytis species using Ulocladium oudemansii are also provided.Type: GrantFiled: June 15, 2001Date of Patent: August 5, 2008Assignee: The Horticulture and Food Research Institute of New Zealand LimitedInventors: Philip George Elmer, Tony Reglinski, Robert Anthony Hill
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Patent number: 7407793Abstract: The present invention relates to a consortium of Nitrosomonas eutropha and Nitrobacter winogradskyi, which is more effective at removing ammonia and nitrite than the commonly used consortium of Nitrosomonas europea and Nitrobacter winogradskyi, particularly in aquaculture such as shrimp ponds. Supplementation of the consortium in aquaculture such as shrimp ponds may lead to an increase in total yield, an increase in size, a decrease in Food Conversion Ratio (less food required per kg of shrimp obtained), and an increase in total per pond sales.Type: GrantFiled: October 11, 2005Date of Patent: August 5, 2008Assignee: Novozymes Biologicals, Inc.Inventor: David J. Drahos
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Publication number: 20080160596Abstract: The present invention relates to an artificial biomembrane and a method for manufacturing such an artificial biomembrane. The beneficial microbial strains, authorized for use in the nation, are concentrated after fermentation. Film-forming raw materials in the water, such as polyvinyl alcohol, sodium alginate and sodium carboxymethyl cellulose, are dissolved into glue liquid, into which the mixture of coal-based activated carbon powder, diatomaceous earth powder sodium acetate and single strain or multiple strains of microbial cells are added. The glue liquid are set into the spray device that is pressed to spray, such that fogdrops are landed on powder beds or fluidized beds for immobilization to form artificial biomembranes. The artificial biomembranes can be manufactured by mechanization and large-scale production, with simple process of immobilization, high efficiency and low cost.Type: ApplicationFiled: March 18, 2008Publication date: July 3, 2008Inventors: Qinsheng Li, Yeqin Wang, Ruoxue Wang, Jing Wang
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Patent number: 7390891Abstract: Disclosed are nucleic acid molecules encoding polypeptides of the telomerase complex. Also disclosed are methods of preparing the nucleic acid molecules and polypeptides, and methods of using these molecules.Type: GrantFiled: October 16, 1997Date of Patent: June 24, 2008Assignee: Amgen Inc.Inventors: Lea Anne Harrington, Murray O. Robinson
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Publication number: 20080124774Abstract: Lactobacillus bacteria having enhanced tolerance to butanols have been isolated. The bacteria are useful for the fermentive production of butanol. New methods for the isolation of butanol tolerant Lactobacillus are also provided.Type: ApplicationFiled: June 12, 2007Publication date: May 29, 2008Inventors: MICHAEL G. BRAMUCCI, Vasantha Nagarajan, Natalia Sedkova, Manjari Singh
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Publication number: 20080102511Abstract: The invention publishes a process for the joint culture of an association of microorganisms using pyrite (FeS2) as an energy source. This invention particularly publishes the use of a pyrite ore as an energy source in the joint culture of an association of Acidithiobacillus ferrooxidans and Acidithiobacillus thiooxidans type isolated microorganisms known as Wenelen DSM 16786 and Licanantay DSM 17318 respectively.Type: ApplicationFiled: September 26, 2007Publication date: May 1, 2008Applicant: BIOSIGMA S.A.Inventors: Pedro Antonio Morales Cerda, Leandro Mauricio Padilla Iglesias, Ricardo Badilla Ohlbaum
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Patent number: 7361497Abstract: Strains of probiotic bacteria, their isolation, characteristics and methods of use to prevent or treat carriage by a food production animal of Salmonella that causes human salmonellosis are provided. Methods for isolating and characterizing the probiotic bacteria are also provided. The present invention further provides methods for using the probiotic bacteria to prevent or treat Salmonella strains that cause human salmonellosis found in food production animals.Type: GrantFiled: October 16, 2003Date of Patent: April 22, 2008Assignee: University of Georgia Research Foundation, Inc.Inventors: Michael P. Doyle, Michelle D. Danyluk
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Patent number: 7341862Abstract: The present invention involves the discovery of a novel endophytic fungus, Muscodor albus, which produces volatile antibiotics that are effective in the treatment of human and animal waste products. Through experimentation, this invention confirms that Muscodor albus can be used in disposable bags in connection with portable toilets to solve the problem of degradation of waste products in situations where humans are removed from sanitary facilities. This invention includes the discovery of non-volatile inhibitors that are also produced by Muscador albus and that are similarly effective in treating human and animal wastes. This invention covers a unique and novel method for preparing Muscador albus for commercial use in the treatment of human and animal wastes. This method entails infesting a seed grain with Muscador albus and then storing it under conditions that will allow the fungus to remain viable.Type: GrantFiled: March 17, 2004Date of Patent: March 11, 2008Assignee: Montana State UniversityInventors: Gary Allan Strobel, David Ezra
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Publication number: 20070221571Abstract: Entrapping immobilization pellets in which microorganisms are entrapped and immobilized, the entrapping immobilization pellets comprising entrapped and immobilized purified water sludge containing nitrifying bacteria.Type: ApplicationFiled: March 20, 2007Publication date: September 27, 2007Applicant: HITACHI PLANT TECHNOLOGIES, LTD.Inventors: Naoki Abe, Koutarou Aoyama, Tatsuo Sumino
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Patent number: 7270993Abstract: Caulobacter optimized for use in expression of heterologous peptides as part of a hybrid Caulobacter S-layer protein are provided as well as methods for producing such Caulobacter. Caulobacter of this invention are deficient in a native Caulobacter protease that cleaves hybrid S-layer proteins. Also provided are Caulobacter libraries and methods for sorting such libraries using cell sorting technology such as FACS.Type: GrantFiled: May 22, 2002Date of Patent: September 18, 2007Assignee: The University of Bristish ColumbiaInventors: John Smit, John F. Nomellini, Wade H. Bingle
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Patent number: 7267816Abstract: Described herein are novel ammonia-oxidizing bacteria as well as isolated nucleotide sequences representative of 16S rDNA of these ammonia-oxidizing bacteria. Particular bacteria of the present invention are tolerant of freshwater environments, saltwater environments or both. Furthermore, in various embodiments, various bacteria of the present invention are capable of surviving a freeze-drying process, and may remain viable thereafter. Compositions including various combinations of the bacteria are further described, as are polymerase chain reaction (PCR) primers and oligonucleotide probes that may be used to detect these bacteria based on their 16S rDNA.Type: GrantFiled: September 10, 2003Date of Patent: September 11, 2007Assignee: Aquaria, Inc.Inventor: Timothy A. Hovanec
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Patent number: 7267772Abstract: The invention provides a biological process for reduction of chemical and biological oxygen demand of pulp and paper industrial effluent using a mixed bacterial consortium comprising of bacterial strains isolated from natural sources which is capable of reducing chemical and biological oxygen demand of pulp and paper industrial effluent to standard discharge limits.Type: GrantFiled: December 28, 2004Date of Patent: September 11, 2007Assignee: Council of Scientific and Industrial ResearchInventors: Rita Kumar, Deepa K. Tiku, Poonam Sharma, Anil Kumar, Rekha Chaturvedi
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Patent number: 7235246Abstract: The present invention relates to the preparation of universal inactivated vaccines and their use in preparing compositions for the prophylaxis and therapy of dermatomycosis. Vaccines according to the present invention have the advantage of conferring immunity against all important causes of dermatomycosis in animals and are characterized by stable immunogenic properties, easy preparation, high content of microconidia and lack of side reactions in animals.Type: GrantFiled: April 21, 2004Date of Patent: June 26, 2007Assignee: Boehringer Ingelheim Vetmedica, GmbHInventors: Igor Polyakov, Ludmilla Ivanova
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Patent number: 7195906Abstract: A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatroy activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.Type: GrantFiled: February 23, 2004Date of Patent: March 27, 2007Assignees: Enterprise Ireland (Trading as BioResearch Ireland), University College Cork--National University of IrelandInventors: John Kevin Collins, Gerald Christopher O'Sullivan, Liam O'Mahony, Fergus Shanahan
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Patent number: 7186544Abstract: Agents for promoting fattening of animals which contain as the active ingredient(s) at least one member selected from among acids originating in hexoses, non-toxic salts thereof and intramolecular esterification products thereof; and a method of promoting fattening by using these agents.Type: GrantFiled: February 3, 2004Date of Patent: March 6, 2007Assignee: Fuso Chemical Co., Ltd.Inventors: Hironari Koyama, Masaaki Okada
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Patent number: 7160715Abstract: An isolated and purified bacterium is provided which was isolated from a high-level radioactive waste site of mixed waste. The isolate has the ability to degrade a wide variety of organic contaminants while demonstrating high tolerance to ionizing radiation. The organism is uniquely suited to bioremediation of a variety or organic contaminants while in the presence of ionizing radiation.Type: GrantFiled: April 30, 2003Date of Patent: January 9, 2007Assignee: Westinghouse Savannah River Company LLCInventor: Carl B. Fliermans
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Patent number: 7148033Abstract: An improved method for detection of total coliforms and E. coli comprising a broth containing an ingredient that will suppress growth of non-coliform gram negative bacteria, and at least one chromogen or fluorogen has been used effectively and is cost effective. Preferred methods include use of filter and/or plates containing the growth-promoting ingredients and the indicators.Type: GrantFiled: November 17, 2003Date of Patent: December 12, 2006Assignee: The United States of America as represented by the Administrator of the U. S. Environmental Protection AgencyInventors: Kristen P. Brenner, Clifford C. Rankin, Yvette R. Roybal-McKenna, Alfred P. Dufour
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Patent number: 7078205Abstract: The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.Type: GrantFiled: June 7, 2002Date of Patent: July 18, 2006Assignee: Millennium Pharmaceuticals, Inc.Inventors: Rajasekhar Bandaru, Maria Alexandra Glucksmann, Rachel E. Meyers, Laura A. Rudolph-Owen
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Patent number: 7070985Abstract: This invention relates to the discovery of a novel endophytic fungus, Muscodor albus, which produces volatile antibiotics that have been shown to be effective in the treatment of human and animal waste products. Through experimentation, this invention confirms that Muscodor albus can be used in disposable bags in connection with portable toilets to solve the problem of degradation of waste products in situations where humans are removed from sanitary facilities. This invention includes the discovery of non-volatile inhibitors that are also produced by Muscodor albus and that are similarly effective in treating human and animal wastes. This invention covers a unique and novel method for preparing Muscodor albus for commercial use in the treatment of human and animal wastes, which involves infesting barley seeds with Muscodor albus and then storing them under conditions that will allow the fungus to remain viable for up to nine months.Type: GrantFiled: April 4, 2003Date of Patent: July 4, 2006Assignee: Montana State UniversityInventors: Gary Allan Strobel, David Ezra
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Patent number: 7067306Abstract: The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).Type: GrantFiled: December 21, 2001Date of Patent: June 27, 2006Assignee: President & Fellows of Harvard CollegeInventors: Rahul Singhvi, Amit Kumar, George M. Whitesides, Donald E. Ingber, Gabriel P. Lopez, Daniel I. C. Wang, Gregory N. Stephanopoulos
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Patent number: 7063836Abstract: The invention includes methods and compositions for treating an animal to inhibit the incidence and growth of E. coli O157:H7 and other pathogenic bacteria. The treatment method comprises administering a therapeutically effective amount of Lactobacillus acidophilus or one or a combination of a number of other probiotic bacteria to an animal. An alternative treatment method comprises administering a therapeutically effective amount of a lactic acid producing bacterium such as Lactobacillus acidophilus in combination with a lactate utilizing bacterium such as Propionibacterium freudenreichii.Type: GrantFiled: November 6, 2002Date of Patent: June 20, 2006Inventors: Bryan E. Garner, Douglas R. Ware
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Patent number: 7052688Abstract: The disclosure is of a combination of lactic acid bacteria comprising: (a) a first component consisting of at least one strain of H2O2-producing lactic acid bacteria; and (b) a second component consisting of at least one strain of arginine-utilizing lactic acid bacteria. The disclosure is also of the use of this combination for making a food supplement, a hygiene product or a pharmaceutical preparation for the prevention and/or treatment of infections and inflammatory conditions caused by bacteria, viruses or fungi, especially in the mouth, vagina, urethra, nose, eyes and ears.Type: GrantFiled: December 21, 2001Date of Patent: May 30, 2006Assignee: VSL Pharmaceuticals, Inc.Inventor: Claudio De Simone
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Patent number: 7022511Abstract: The invention provides a novel process of lignin degradation using a consortium of bacteria. To date, biodegradation of lignin has been centered to fungi only. Degradation of lignin by bacteria confer a new understanding that may be of tremendous industrial significance. This invention also discloses the isolation and acclimatization of ligninolytic bacteria from a specific site.Type: GrantFiled: March 21, 2003Date of Patent: April 4, 2006Assignee: Council of Scientific & Industrial ResearchInventors: Rita Kumar, Anil Kumar
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Patent number: 7001758Abstract: A biodegradation process for the organophosphonate product of Sarin (O-isopropyl methylphosphonofluoridate) hydrolysis, i.e., isopropylmethylphosphonate (IMPA). This process provides a feasible biodegradation demilitarization alternative to Sarin incineration. Public opposition of nerve agent incineration is widespread, and alternative methods are sought to help the U.S. Army meet the 2007 demilitarization deadline imposed by the Chemical Weapons Convention. This process uses a two-step approach to IMPA biodegradation. In the first step, a concentrated IMPA solution is used as the sole nutritional carbon and phosphorus source for microbial cultures. The second step involves diluting the culture and adding an inexpensive carbon source to encourage bacterial phosphate assimilation. The biodegradation typically involves a consortium of microorganisms comprising Methylobacterium radiotolerans GB21, Agrobacterium tumefaciens GB2GA, Klebsiella oxytoca GB2CS, GB272, Aureobacterium sp.Type: GrantFiled: May 12, 2003Date of Patent: February 21, 2006Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Ilona J. Fry, Joseph J. DeFrank, James P. Earley
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Patent number: 6989266Abstract: A cement paste containing microbial cells which has a sustained effect and an excellent function of purifying water. This cement paste contains a mixture of Bacillus subtilis, Bacillus thuringiensis and Bacillus sphaericus cells at a mixing ratio by mass of 0.1 to 50:0.1 to 50:0.1 to 50.Type: GrantFiled: December 10, 2001Date of Patent: January 24, 2006Assignee: Koyoh Corporation, Ltd.Inventors: Masayuki Koga, Yoko Koga
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Patent number: 6967087Abstract: The present invention relates to a novel obligately symbiotic thermophile Symbiobacterium toebii SC-1(Accession NO: KCTC 0685BP), and a thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1. The present invention also relates to a pure culture method of Symbiobacterium toebii SC-1, a method of growth measurement for Symbiobacterium toebu SC-1 and its relative symbiotic bacteria showing low-growth yield using nitrate respiration, and a screening method of relative symbiotic strains of Symbiobacterium toebii SC-1 from the environment using a specific antibody to it. Therefore, the thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1 in this invention can provide more stable catalysts in enzymatic biotransformation processes which enzymatically produce valuable medico-amino acids 3,4-dehydroxy-L-phenylalanine (L-DOPA) and L-tryptophan.Type: GrantFiled: July 14, 2000Date of Patent: November 22, 2005Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Moon-Hee Sung, Seung-Goo Lee, Sung-Keun Rhee, Seung-Pyo Hong, Dae-Joong Kang, Su-Mi Kim, Chul-Joong Kim, Jin-Woo Bae, Che Ok Jeon, Joong-Jae Kim, Kwang Kim, Jae Jun Song
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Patent number: 6953574Abstract: A method of producing a hydrolyzed fermented medium containing microorganisms includes providing at least one solid plant product reduced to small pieces and mixed with sugar and biocompatible liquid such as milk for fermentation at a temperature of between 35 and 58 degrees C. until the acidity of the medium reaches the range of 300 to 900 in Terner degrees. Alternatively, the medium is prepared by mixing in predetermined amounts of sprouted grains, biocompatible liquid inoculated with at least one of a variety of non-pathogenic microorganisms, vegetables, fruits, berries, high protein products, herbs, sugar, and a chemical element such as potassium. The mixture is then fermented at a selected temperature for a specified length of time to reach high acidity and high concentration of products of bacterial metabolism. A liquid phase is separated from a solid sediment phase and can be used to treat a wide variety of diseases.Type: GrantFiled: June 21, 2002Date of Patent: October 11, 2005Assignee: Technology Commercialization, Inc.Inventors: Constantin Vladimirovich Sobol, Yuzefa Tsezarevna Sobol
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Patent number: 6905864Abstract: Polyaromatic hydrocarbons are found in contaminated soils and groundwater and are a large class of compounds for which treatment by bioremediation is sought. Accordingly, indigenous organisms that can degrade polyaromatic hydrocarbon are needed. Presented are strains of the Paenibacillus genus that degrade low molecule weight polyaromatic, and, in the presence of phenanthrene, high molecular weight polyaromatic hydrocarbons. These bacteria strains are unique among PAH-degrading bacterial strains because they form endospores and therefore can survive adverse environmental conditions. Among the strains presented are several from “P. naphthalenovorans”, a newly described species. Also presented are compositions for bioremediation comprising the bacterial strains of the invention, and a method for isolating the strains and a method for using the strains for bioremediation.Type: GrantFiled: May 24, 2002Date of Patent: June 14, 2005Assignee: Rutgers, the State UniversityInventors: Max M. Haggblom, Lori Daane
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Patent number: 6884351Abstract: The present invention is directed to methods of remediating sewage matter, reducing the amount of sludge in sewage and reducing odor-causing matter in sludge. The invention is further directed to compositions having specific genetic characteristics useful in bioremediation of sewage matter and methods of producing same.Type: GrantFiled: May 7, 2003Date of Patent: April 26, 2005Inventor: Mary L. Lytal
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Patent number: 6872399Abstract: The present invention relates to the preparation of universal inactivated vaccines and their use in preparing compositions for the prophylaxis and therapy of dermatomycosis. Vaccines according to the present invention have the advantage of conferring immunity against all important causes of dermatomycosis in animals and are characterized by stable immunogenic properties, easy preparation, high content of microconidia and lack of side reactions in animals.Type: GrantFiled: February 28, 2002Date of Patent: March 29, 2005Assignee: Boehringer Ingelheim Vetmedica GmbHInventors: Igor Dimitriesich Polyakov, Ludmilla Ivanova
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Patent number: 6855472Abstract: The invention is to provide polyhydroxyalkanoate of a novel structure enabling application to wider fields, and a producing method therefor. The invention also provides a biodegradable charge control agent having excellent charging characteristics, excellent dispersibility in the toner resin and improved spent property. The polyhydroxyalkanoate of the present invention is featured by including, in the polymer molecule, a units represented by the general formulas (1) and (2) and at least one of the units represented by the general formulas (3) to (6).Type: GrantFiled: April 29, 2002Date of Patent: February 15, 2005Assignee: Canon Kabushiki KaishaInventors: Takeshi Imamura, Etsuko Sugawa, Tetsuya Yano, Takashi Kenmoku
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Patent number: 6841149Abstract: A mixture of probiotics effective to reduce the contamination of enteric bacteria in humans and other monogastric animals. The mixture of probiotics includes one or more acid-producing bacteria strains and one or more yeast strains, and may advantageously be supplemented with a source of nutrients, such as prebiotics including fructo-oligosaccharides. In a preferred embodiment, said one or more bacteria strains contain Enterococcus faecium strain NCIMB #10415, and said one or more yeast strains contain NCYC #47 and CNCM I-1079.Type: GrantFiled: July 24, 2002Date of Patent: January 11, 2005Assignees: Agri-King, Inc., Mayo Foundation for Medical Education and ResearchInventors: David A. Spangler, Patrick K. Brown, Thomas E. Witzig
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Strain of lactic acid bacterium and edible compositions, drugs and veterinary products containing it
Publication number: 20040248278Abstract: Describes a new strain of Streptococcus thermophilus ssp. Salivarius (deposited on 4 Dec. 2001 at the DSMZ—Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany, with accession No. DSM 14667) and edible compositions, drugs and veterinary products containing it. The use of the said strain is particularly effective in the prevention/treatment of hepatic steatosis (fatty liver) and in nonalcoholic hepatic steatosis.Type: ApplicationFiled: April 7, 2004Publication date: December 9, 2004Inventor: Claudio De Simone -
Patent number: 6827953Abstract: The present invention provides a composition comprising an untreated or treated culture of a mixed microorganism and a functional food comprising said composition. A composition comprising an untreated or treated culture of a mixed microorganism comprising at least three lactic acid bacteria selected from the group consisting of Lactobacillus delbrueckii, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus fermentum, Lactobacillus casei, Lactobacillus rhamnosus, Lactococcus lactis and Streptococcus thermophilus, mixed with Saccharomyces cerevisiae, and a functional food comprising said composition.Type: GrantFiled: October 4, 1999Date of Patent: December 7, 2004Assignees: Riken, A.L.A. CorporationInventors: Takeo Mizutani, Ryouichi Shin, Momoyo Suzuki, Kazushi Miura
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Patent number: 6818211Abstract: The invention discloses a Gram-positive microorganism, Bacillus megaterium that effectively and efficiently degrades fats, oils and grease. A composition comprising said microorganism and a method for degrading fatty acids and grease are also disclosed. Availability of glycerol to the biodegrading microorganism was discovered to enhance biodegradation.Type: GrantFiled: April 23, 2002Date of Patent: November 16, 2004Assignee: Novozymes Biologicals, Inc.Inventors: Jessi Lind Tisinger, Domenic A. Paone, Jonathan Leder, David J. Drahos
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Patent number: 6812021Abstract: According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be associated with the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vacaccines to immunize a patient against microbial infection.Type: GrantFiled: September 10, 2001Date of Patent: November 2, 2004Assignee: Microscience LimitedInventors: Martin John Glenton Hughes, Joseph David Santangelo, Jonathan Douglas Lane, Robert Feldman, Joanne Christine Moore, Richard James Dobson, Paul Everest, Gordon Dougan, Rebecca Kerry Wilson
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Patent number: 6808917Abstract: Fungal/bacterial atagonist combinations, a seed coated with one of the combinations and a plant protected from plant pathogens by one of the combinations. The invention is also a fungal/bacterial antagonist combination and its use for controlling plant pathogens as a biocontrol agent, bio-pesticide or bio-fungicide.Type: GrantFiled: February 1, 2002Date of Patent: October 26, 2004Inventor: Thomas D. Johnson
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Patent number: 6797507Abstract: The present invention describes a material and a method for controlling fungi. The method consists of disposing a naturally formed chitinase about an area to be protected. The naturally formed chitinase is produced from worm castings and the worm castings may be disposed naturally, in the form of timed-release pellets, or in a liquid form. The area to be protected includes plants and structures. The naturally formed chitinase may be disposed about the base of the plant or structure, or on the leaves of the plant.Type: GrantFiled: September 20, 2002Date of Patent: September 28, 2004Inventor: George E. Hahn
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Patent number: 6787348Abstract: Liquid microbial starter culture that retains its initial metabolic activity during storage for extended periods of time. Such liquid starter cultures are useful in the manufacturing of food and feed products. Starter cultures of the invention include culture of lactic acid bacteria, e.g. Lactococcus species.Type: GrantFiled: December 22, 1999Date of Patent: September 7, 2004Assignee: CHR. HansenInventors: Boerge Kringelum, Lene Kragelund
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Patent number: 6780317Abstract: A method of purifying waste water biologically by using three particularly suitable bacteria: Bacillus sp. DT-1, Pseudomonas azelaica, DT-2, and/or Rhizobus sp. DT-5, or mixed populations thereof. The invention further relates to the bacteria and the mixed populations and use thereof in purifying waste water. The invention further relates to a bioreactor including the bacteria.Type: GrantFiled: May 13, 2002Date of Patent: August 24, 2004Assignee: Oy Clewer LtdInventors: Jussi Uotila, Gennadi Zaitsev
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Patent number: 6762280Abstract: In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or proteins that can serve as FRET substrates and (2) modified peptides or proteins that can serve as immobilized substrates. In both types a fluorescent molecules is present in the substrate, eliminating the requirement for the addition of a fluorigenic reagent. The assays described can be readily adapted for use in automated or robotic systems.Type: GrantFiled: September 25, 2001Date of Patent: July 13, 2004Assignee: The United States of America as represented by the Secretary of the ArmyInventors: James J. Schmidt, Robert G. Stafford
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Patent number: 6750049Abstract: A bioengineered synthesis scheme for the production of 1,2,3,4-tetrahydroxybenzene from a carbon source is provided. Methods of producing 1,2,3,4-tetrahydroxybenzene from a carbon source based on the synthesis scheme are also provided. Methods are also provided for converting 1,2,3,4-tetrahydroxybenzene to 1,2,3-trihydroxybenzene by catalytic hydrogenation.Type: GrantFiled: May 7, 2002Date of Patent: June 15, 2004Assignee: Board of Trustees operating Michigan State UniversityInventors: John W. Frost, Chad A. Hansen
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Publication number: 20040110271Abstract: A process for treating waste comprising the steps of (i) adding a first innoculum comprising sulfide-utilizing bacteria to a sulfide-rich organic waste to produce a lowered-sulfide waste, (ii) adding a second innoculum comprising organic digesting bacteria to the lowered-sulfide waste to produce a digested waste, and (iii) adding to the digested waste at least one of (a) a third innoculum comprising bacteria capable of converting a nitrogen-containing compound to N2 to produce a lowered nitrogen waste, and (b) a fourth innoculum comprising phosphorous absorbing bacteria to produce a phosphorous enriched bacteria fraction and a phosphorous depleted waste fraction.Type: ApplicationFiled: December 10, 2002Publication date: June 10, 2004Inventor: Gregory S. Patterson
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Patent number: 6709853Abstract: Immobilized cell beads incorporating formulated microbial consortium comprising a synergistic mixture of the following bacterial strains namely, Enterobacter sakazaki, Pseudomonas aeruginosa and Aeromonas sobria selected from the following isolated bacterial strains namely, Yersinia enterocolitica, Aeromonas sobria, Klebsiella pneumoniae, Serratia liquefaciens, Enterobacter sakazaki, Citrobacter amalonaticus, Pseudomonas fluorescens, Pseudomonas aeruginosa, Enterobacter cloaca, Acinetobacter calcoaceticus are prepared, the formulated microbial consortium is immobilized in an appropriate immobilizing agent resulting in the formation of beads and the beads are used for instant BOD estimation using an electronic device and the formulated cell beads are reusable and are capable of assimilating most of the organic matter present in varied industrial effluents.Type: GrantFiled: April 3, 2001Date of Patent: March 23, 2004Assignee: Council of Scientific & Industrial ResearchInventors: Rita Kumar, Shikha Rastogi, Alka Sharma, Tushya Kumar Saxena
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Patent number: RE40023Abstract: A pharmaceutical composition containing several different bacteria including Streptococcus thermophilus, Lactobacilli and Bifidobacteria is disclosed. The bacteria are present in the composition at a total concentration of 1×1011 to 1×1013 per gram. Further, methods of using the pharmaceutical are disclosed which include treatment of a gastrointestinal disorder and hypercholestermia. Also a method for modulating a host's immune response is disclosed.Type: GrantFiled: March 15, 2006Date of Patent: January 22, 2008Inventor: Claudio DeSimone