Transformants Patents (Class 435/254.11)
  • Patent number: 11890320
    Abstract: The present disclosure describes the C-type lectin CLEC11a as a bone growth factor. Clec11a-deficient mice showed reduced bone volume and mineralization, while bone resorption remained unchanged. Administration of recombinant Clec11a systemically promoted bone formation in mice at risk for osteoporosis.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: February 6, 2024
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Sean Morrison, Rui Yue
  • Patent number: 11846628
    Abstract: As described herein, a hybrid voltage sensor genetically-encoded voltage indicator (GEVI) for mitochondria or endoplasmic reticulum includes a transmembrane domain, and a fluorescent protein, wherein a terminus of the transmembrane domain and a terminus of the fluorescent protein are covalently linked directly or by a linker comprising 1 to 20 amino acids, and wherein the transmembrane domain comprises SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or a peptide with greater than 85%, 90%, 95% or 98% identity to SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 or SEQ ID NO: 4. Also described are expression vectors, expression cassettes, and organelle membranes, as well as methods of determining the voltage across an organelle using the GEVIs.
    Type: Grant
    Filed: August 23, 2022
    Date of Patent: December 19, 2023
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Meyer Jackson, Masoud Sepehri Rad
  • Patent number: 11827880
    Abstract: Disclosed herein are compositions that comprise engineered polynucleotides, pharmaceutical compositions comprising the same, methods of making the same, and methods of treatment comprising the compositions that comprise the engineered polynucleotides.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: November 28, 2023
    Assignee: Shape Therapeutics Inc.
    Inventors: David Huss, Prashant Mali, Anupama Lakshmanan, Christopher Nye, Yiannis Savva, Liana Stein, Richard Sullivan, Rafael Ponce, Susan Byrne
  • Patent number: 11793216
    Abstract: The invention provides an animal feed composition comprising microbial ?-amylase, for example, an animal feed composition comprising transgenic plant material comprising a microbial ?-amylase (e.g., a thermostable microbial ?-amylase). The invention further provides methods of increasing animal performance and/or the efficiency of feed utilization by an animal (e.g., for milk or meat production), comprising feeding to the animal an animal feed composition of the present invention.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: October 24, 2023
    Assignee: Syngenta Participations AG
    Inventors: Eileen Dorothea Watson, David Witherspoon, Tammiraj Kumar Iragavarapu
  • Patent number: 11780891
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: November 3, 2021
    Date of Patent: October 10, 2023
    Inventors: Steven D Gruver, Heather Kozy, Jessica O'Rear, Barbara Rosen, Ute Schellenberger, Jun-Zhi Wei, Weiping Xie, Xiaohong Zhong, Genhai Zhu
  • Patent number: 11758854
    Abstract: Methods of propagating Arbuscular Mycorrhizal Fungi (AMF) are described that do not require the addition of, or presence of, any detectable live host plant material or live plant root material. The method comprises addition of water and optionally exposure to sunlight. It was surprisingly found that soil devoid of any detectable live host plant material, including host plant roots, is capable of supporting AMF reproduction, though it is widely believed that AMF are obligate symbionts requiring live plant roots for colonization to reproduce. Described methods optionally include active removal of living host plant material from the soil prior to AMF inoculation. Optionally, phosphorous compounds are added to the soil prior to inoculation. It was found that addition of phosphorous compounds, such as phosphite, to the soil enhances the growth of AMF spores by as much as three-fold over controls having no added phosphorous compounds.
    Type: Grant
    Filed: March 9, 2022
    Date of Patent: September 19, 2023
    Assignee: Terra Microbes, LLC
    Inventor: Stephen Earl Williams
  • Patent number: 11746353
    Abstract: A Saccharomyces cerevisiae strain with high yield of ethyl butyrate and a construction method and an application thereof are provided. The strain is obtained by over-expressing in the starting strain acetyl coenzyme A acyl transferase gene Erg10, 3-hydroxybutyryl coenzyme A dehydrogenase gene Hbd, 3-hydroxybutyryl coenzyme A dehydratase gene Crt, trans-2-enoyl coenzyme A reductase gene Ter, and alcohol acyl transferase gene AAT. Compared to the starting bacteria not producing ethyl butyrate, the yield of ethyl butyrate of the constructed strain reaches 77.33±3.79 mg/L, the yield of the ethyl butyrate of the strain with double copy expression of gene Ter and gene AAT reaches 99.65±7.32 mg/L, increased by 28.9% compared with the EST strain, and 40.93±3.18 mg/L of ethyl crotonate is unexpectedly produced.
    Type: Grant
    Filed: December 25, 2020
    Date of Patent: September 5, 2023
    Assignee: Tianjin University of Science and Technology
    Inventors: Yefu Chen, Yanrui Ma, Yongjing Du, Sen Jiang, Jinying Ren, Guo Zhang, Xinyue Kang, Peng Zheng, Xiaole Wu, Dongguang Xiao, Xuewu Guo
  • Patent number: 11746128
    Abstract: Compositions and methods are provided for producing materials having increased immunoglobulin binding capacities, the materials including full-length or truncated forms of protein A, protein G, protein A/G, protein L and other immunoglobulin-binding proteins or peptides, which moieties contain polypeptide domains, or polypeptide-oligopeptide combinations. Also provided are separation matrices containing the moieties and methods of using the separation matrices for separation of immunoglobulins or immunoglobulin containing proteins.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: September 5, 2023
    Assignee: HurraH S.A.R.L
    Inventors: Rajiv Datar, Carole Laine, Kajal Arora
  • Patent number: 11708408
    Abstract: Chimeric antigen receptors containing human CD19 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: July 25, 2023
    Assignees: Lentigen Technology Inc., The U.S.A. as represented by the Secretary, Department of Health and Human Services
    Inventors: Dina Schneider, Rimas J. Orentas, Boro Dropulic, Dimiter S. Dimitrov, Zhongyu Zhu
  • Patent number: 11685771
    Abstract: Provided are recombinant Factor VIII proteins, e.g., human Factor VIII proteins with heterologous moieties inserted into flexible permissive loops located in the Factor VIII A domains, while retaining the procoagulant activity of Factor VIII.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: June 27, 2023
    Assignee: BIOVERATIV THERAPEUTICS INC.
    Inventor: John Kulman
  • Patent number: 11655444
    Abstract: Methods of standardizing a fermentation process may include obtaining a fluidic sample, measuring one or more physical parameters of the sample, comparing the measurement of the physical parameter of the material to a baseline value of the physical parameter for the fermentation process, and responsive to a deviation of the measurement of the physical parameter from the baseline value, determining a remediation action based on a correlation between the physical parameter and regulatory genes of a fermentation organism.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: May 23, 2023
    Assignee: PRECISION FERMENTATION, INC.
    Inventors: Steven B. Haase, Adam R. Leman, David S. Morris, Ashlee M. Valente
  • Patent number: 11613571
    Abstract: The present disclosure relates to compositions comprising antibody variants, for treating interleukin 5 (IL-5) mediated diseases, and related methods.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: March 28, 2023
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Chika Akinseye, Tejinder Bhinder, Li Cui, Steven Grant, Laura Hook, Alan Peter Lewis, Martin Anibal Orecchia
  • Patent number: 11607646
    Abstract: A process for selective capture of CO2 from gaseous mixture comprising of: (a) spraying a bio-amine cluster; (b) capturing CO2 through bio-amine cluster; and (c) desorption of CO2 through solar assisted electro de-amination, wherein the bio-amine cluster is comprises of: an amine cluster comprising of a quaternary Isobutylamine (IB) with amine terminated Poly(L-lactide) as the chelating agent; a cluster stabilizing agent; a cluster micelle stabilizing agent; and a carbonic anhydrase (CA) functionalized matrix in 0.05-0.2 wt % of total wt % of bio-amine cluster and wherein the CA is obtained from a source selected from the group consisting of Bacillus thermoleovorans, Pseudomonas fragi, Bacillus stearothermophilus and Arthrobacter sp. and a process for production of bio-amine cluster.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: March 21, 2023
    Assignee: INDIAN OIL CORPORATION LIMITED
    Inventors: Manoj Kumar, Prakash Chandra Sahoo, Suresh Kumar Puri, Sankara Sri Venkata Ramakumar
  • Patent number: 11578338
    Abstract: This disclosure concerns compositions and methods for novel pesticidal proteins, polynucleotides encoding such proteins, use of such novel pesticidal proteins to control Hemipteran/Lepidopteran plant pests, and transgenic plants that produce, and are protected, by these novel pesticidal proteins are described.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: February 14, 2023
    Assignee: CORTEVA AGRISCIENCE LLC
    Inventors: William Beeson, IV, Jeffrey Church
  • Patent number: 11478542
    Abstract: This invention provides immunogenic compositions comprising an immune stimulant and an respiratory syncytial virus (RSV) oligopeptide or an unglycosylated RSV polypeptide. The RSV oligopeptides are shown in SEQ ID NO: 3-33. The unglycosylated RSV polypeptide may consist essentially of the ectodomain of an RSV G protein, such as that shown in SEQ ID NO: 2 or the ectodomain of an RSV F protein such as the ectodomain of the F protein shown in SEQ ID NO: 39.
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: October 25, 2022
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Surender Khurana, Hana Golding
  • Patent number: 10620222
    Abstract: Methods for diagnosing a predisposition to developing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protein-coupled receptor activity are described. Specific embodiments of the methods involve measuring a change in impedance signals of cells expressing a receptor coupled to a Gi protein with a ligand. To identify compounds useful in treatment, the cell is contacted with a test compound and a ligand. A higher impedance in the presence relative to the absence of said test compound is indicative that the test compound is useful for treating scoliosis.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: April 14, 2020
    Assignee: CHU Sainte-Justine
    Inventors: Alain Moreau, Marie-Yvonne Akoume Ndong
  • Patent number: 10323250
    Abstract: The present invention aims to provide a promoter showing high expression activity in microorganisms belonging to the genus Mortierella. The present invention provides a polynucleotide which contains any one nucleotide sequence selected from the group consisting of SEQ ID NO: 1 to 28, or a variant thereof.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: June 18, 2019
    Assignee: SUNTORY HOLDINGS LIMITED
    Inventors: Misa Ochiai, Jun Ogawa, Eiji Sakuradani, Akinori Ando
  • Patent number: 9896706
    Abstract: It is an object of the present invention to provide a method for producing ?-glucan having excellent immunopotentiating effects at a lower cost. Black yeast (Aureobasidium pullulans) is cultured using cells of lactic acid-producing bacteria and/or derivatives thereof as a nutrient source and is allowed to produce ?-glucan.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: February 20, 2018
    Inventor: Shigenobu Miura
  • Patent number: 9527921
    Abstract: The present invention provides an anti-human Notch4 antibody or a Notch4 binding fragment thereof that may have neutralizing activity against human Notch4, as well as a pharmaceutical composition comprising the same as the active ingredient. The present inventors obtained a mouse anti-human Notch4 antibody that has high neutralizing activity and binding affinity towards human Notch4 and determined the complementarity determining region (CDR) sequence of the mouse anti-human Notch4 antibody. This enabled the production of a humanized antibody comprising the variable region of heavy and light chains as well as the CDR sequence of the mouse anti-human Notch4 antibody.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: December 27, 2016
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Yoshimasa Sakamoto, Yusuke Adachi, Junji Matsui, Yu Kato, Yoichi Ozawa, Takanori Abe, Ken Ito, Yuya Nakazawa, Sho Tachino, Katsuhisa Suzuki, Kishan Agarwala, Kana Hoshino, Masahiko Katayama
  • Patent number: 9409975
    Abstract: Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species and/or Staphylococcus species.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: August 9, 2016
    Assignees: Children's Hospital Medical Center, University of Cincinnati, Yale University
    Inventors: Margaret K. Hostetter, Long Lu, Julianne Vernadette Green, Alexey Porollo, Kris I. Orsborn, Khoon Ghee Queenie Tan, Kenneth Greis, David Andes
  • Publication number: 20150147365
    Abstract: The present invention relates to an oral composition comprising a volatile sulphur compound breath-odour controlling amount of methyl mercaptan oxidase. The oral composition may be used in a method for controlling breath-odour in a host, which method comprises applying the composition to the oral cavity of that host. The invention also provides a polypeptide having methyl mercaptan oxidase activity, wherein said polypeptide is: (a) a polypeptide comprising an amino acid sequence as set out in SEQ ID NO: 2; (b) a polypeptide comprising an amino acid sequence having at least 50% sequence identity with the amino acid sequence of SEQ ID NO: 2; (c) a polypeptide encoded by a polynucleotide comprising the polynucleotide sequence as set out in SEQ ID NO: 1 or SEQ ID NO: 3; or (d) a fragment of a polypeptide as defined in (a), (b) or (c).
    Type: Application
    Filed: May 13, 2013
    Publication date: May 28, 2015
    Inventors: Luppo Edens, Evert Tjeerd Van Rij, Marco Jan Lambertus De Groot
  • Publication number: 20150150152
    Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel ecdysone receptor/chimeric retinoid X receptor-based inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large-scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
    Type: Application
    Filed: November 24, 2014
    Publication date: May 28, 2015
    Inventors: Marianna Zinovievna KAPITSKAYA, Subba Reddy Palli
  • Publication number: 20150150157
    Abstract: Prephenate dehydrogenases and arogenate dehydrogenase polynucleotide and polypeptide sequences are provided herein. These polypeptides are all insensitive to effector based feedback inhibition. Polypeptides with these activities and lacking feedback inhibition by the product were not previously identified and characterized from plants. The polypeptides may be used to generate constructs and transgenic cells or plants. Methods of increasing production of products of the tyrosine or HPP pathway by increasing expression of the polynucleotides provided herein in plants or cells overexpressing the polypeptides are provided. In addition overexpression of the polypeptides in plant cells increases resistance to herbicides.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 28, 2015
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Hiroshi A. Maeda, Craig Albert Schenck
  • Publication number: 20150147343
    Abstract: Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.
    Type: Application
    Filed: July 2, 2014
    Publication date: May 28, 2015
    Applicant: University of Zurich
    Inventors: Roger NITSCH, Christoph Hock, Christoph Esslinger, Marlen Knobloch, Kathrin Tissot, Jan Grimm
  • Publication number: 20150143584
    Abstract: This invention relates generally to nucleic acid sequences encoding proteins that are related to the presence of seed storage compounds in plants. More specifically, the present invention relates to Arabidopsis thaliana, Brassica napus, Glycine max and Oryza sativa nucleic acid sequences encoding sugar and lipid metabolism regulator proteins and the use of these sequences in transgenic plants. In particular, the invention is directed to methods fir manipulating sugar-related compounds and for increasing oil level and altering the fatty acid composition in plants and seeds. The invention further relates to methods of using these novel plant polypeptides to stimulate plant growth and/or to increase yield and/or composition of seed storage compounds.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 21, 2015
    Applicant: BASF PLANT SCIENCE GMBH
    Inventors: Heiko A. Haertel, Garima Bhatt
  • Publication number: 20150140638
    Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: February 2, 2015
    Publication date: May 21, 2015
    Inventor: Nikolaj Spodsberg
  • Publication number: 20150140641
    Abstract: The present invention relates to variant endoglucanases having improved thermoactivity, improved thermostability, and improved viscosity reduction activity over wild-type M. thermophila endoglucanase.
    Type: Application
    Filed: November 14, 2014
    Publication date: May 21, 2015
    Inventors: XIYUN ZHANG, SACHIN PATIL, JIE YANG, ISH KUMAR DHAWAN
  • Publication number: 20150140631
    Abstract: Described is a method for generating conjugated dienes through a biological process. More specifically, the application describes a method for producing conjugated dienes (for example butadiene, isoprene or dimethylbutadiene) from light alkenols via enzymatic dehydration, in particular by making use of an alkenol dehydratase.
    Type: Application
    Filed: January 28, 2015
    Publication date: May 21, 2015
    Inventor: Philippe Marliere
  • Publication number: 20150140588
    Abstract: The present invention relates to variants with improved activity in an amide-bond reaction. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Application
    Filed: July 3, 2012
    Publication date: May 21, 2015
    Applicant: Novozymes A/S
    Inventors: Werner Besenmatter, Allan Svendsen
  • Publication number: 20150140021
    Abstract: The invention provides, inter alia, conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular domain epitope of a mammalian PLVAP protein. These agents specifically target HCC tumors and treat the HCC. The invention also provides methods of using these conjugates, such as methods of treating HCC by administering the conjugates provided by the invention or compositions provided by the invention, such as pharmaceutical compositions.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 21, 2015
    Inventors: Kuo-Jang Kao, Yun-Hsin Wang
  • Publication number: 20150140620
    Abstract: This disclosure describes engineered biosynthetic pathways, recombinant cells, and methods relating to biosynthesis of esters. The recombinant cells may be modified to exhibit increased biosynthesis of an ester compared to a wild-type control. The recombinant cell may be incubated in medium that includes a carbon source under conditions effective for the recombinant cell to produce an ester. This disclosure also describes a method that generally includes introducing into a host cell a heterologous polynucleotide encoding at least one polypeptide that catalyzes a step in converting a carbon source to an ester, wherein the at least one polynucleotide is operably linked to a promoter so that the modified host cell catalyzes conversion of the carbon source to an ester.
    Type: Application
    Filed: March 14, 2013
    Publication date: May 21, 2015
    Applicant: Regents of The University of Minnesota
    Inventors: Kechun Zhang, Mingyong Xiong, Yi-Shu Tai
  • Patent number: 9034608
    Abstract: The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: May 19, 2015
    Assignee: DSM IP ASSETS, B.V.
    Inventors: Hendrik Wouter Wisselink, Antonius Jeroen Adriaan Van Maris, Jacobus Thomas Pronk, Paul Klaassen, Rene Marcel De Jong
  • Patent number: 9034599
    Abstract: DNA encoding a monomeric variant of red fluorescent protein eqFP611 comprising an amino acid sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No. 3 and SEQ ID No. 5. DNA comprising a nucleotide sequence selected from the group consisting of SEQ ID No. 2, SEQ ID No. 4 and SEQ ID No. 6.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: May 19, 2015
    Assignee: Universitat Ulm
    Inventors: Jörg Wiedenmann, Simone Kredel, Franz Oswald, Gerd Ulrich Nienhaus
  • Publication number: 20150132816
    Abstract: The invention relates to recombinant cells and their use in the production of branched medium-chain alcohols such as 4-methyl-1-pentanol.
    Type: Application
    Filed: October 31, 2014
    Publication date: May 14, 2015
    Inventors: Kristala Lanett Jones Prather, Micah James Sheppard, Aditya Kunjapur
  • Publication number: 20150132824
    Abstract: The present invention relates to isolated polypeptides having xanthan degrading activity, catalytic domains and polynucleotides encoding the polypeptides and catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides and catalytic domains.
    Type: Application
    Filed: May 7, 2013
    Publication date: May 14, 2015
    Inventors: Dorotea Raventos Segura, Peter Fischer Halin, Anders Viksoe-Nielsen, Lars Anderson, Martin Simon Borchert, Leigh Murphy, Astrid Boisen, Lorena G. Palmén, Kenneth Jensen, Carsten Sjoeholm, Tine Hoff, Charlotte Blom
  • Publication number: 20150132807
    Abstract: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 14, 2015
    Inventors: Nicholas J. Agard, Oscar Alvizo, Melissa Ann Mayo, Stefanie Ng Minor, James Nicholas Riggins, Jeffrey C. Moore
  • Publication number: 20150133379
    Abstract: The present invention relates to a fusion protein comprising a skin-penetrating peptide, a polynucleotide encoding the fusion protein, an expression vector comprising the polynucleotide, a transformant comprising the expression vector, a method for preparing the fusion protein, a cosmetic composition for improving skin conditions, which comprises the fusion protein, and a pharmaceutical composition for external skin use, which comprises the fusion protein. The fusion protein of the invention comprises a skin-penetrating peptide bound to a physiologically active protein. The fusion protein significantly enhances the skin penetration and skin retention of the physiologically active protein while maintaining or enhancing the ability of the physiologically active protein to synthesize a material showing physiologically active effects. Thus, it can be widely used as an active ingredient in functional cosmetic compositions and pharmaceutical compositions for external skin use.
    Type: Application
    Filed: April 30, 2014
    Publication date: May 14, 2015
    Inventors: Seol Hoon Lee, Sang Hwa Lee, Nae Gyu Kang, Eu Gene Hur
  • Publication number: 20150132218
    Abstract: The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same.
    Type: Application
    Filed: October 20, 2014
    Publication date: May 14, 2015
    Inventors: Jyoti Asundi, Ron Firestein, Paul Polakis, Chie Sakanaka, Peter Chang, Rayna Takaki Venook
  • Publication number: 20150132813
    Abstract: This disclosure describes, generally, recombinant cells modified to exhibit increased biosynthesis of pentanoic acid, methods of making such recombinant cells, and methods of inducing the cells to produce pentanoic acid. This disclosure also describes, generally, recombinant cells modified to exhibit increased biosynthesis of 2-methylbutyric acid, methods of making such recombinant cells, and methods of inducing the cells to produce 2-methylbutyric acid.
    Type: Application
    Filed: March 13, 2013
    Publication date: May 14, 2015
    Inventors: Kechun Zhang, Yogesh K. Dhande
  • Publication number: 20150132820
    Abstract: An object is to efficiently produce thermostable catalase at low cost by expressing it as a recombinant protein in large quantity. A recombinant microorganism capable of efficiently expressing thermostable catalase can be provided by obtaining a DNA necessary for efficiently producing it as a recombinant protein, and the thermostable catalase can be efficiently produced at low cost by cultivating the obtained recombinant microorganism. Hydrogen peroxide can be efficiently decomposed at low cost, even at high temperature, by treating a solution containing hydrogen peroxide with the thermostable catalase of the present invention.
    Type: Application
    Filed: January 27, 2015
    Publication date: May 14, 2015
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Kaoru OKAKURA, Fusuke MAZUKA, Takayoshi FUKUSHIMA, Koichiro MURASHIMA
  • Publication number: 20150125902
    Abstract: Provided are isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains.
    Type: Application
    Filed: August 24, 2012
    Publication date: May 7, 2015
    Applicant: Novozymes A/S
    Inventors: Tianqi Sun, Ming Li
  • Publication number: 20150125934
    Abstract: A simple and inexpensive method for selectively culturing a microorganism which method makes it possible to selectively culture a microorganism of interest even without using a sterilization operation or an antibiotic substance is provided. The method according to the present invention selectively culturing a microorganism includes the step of culturing, in a culture medium containing phosphorous acid as a sole phosphorous source, a recombinant microorganism into which a phosphite dehydrogenase gene has been introduced.
    Type: Application
    Filed: August 8, 2013
    Publication date: May 7, 2015
    Inventors: Akio Kuroda, Ryuichi Hirota, Takencri Ishida
  • Publication number: 20150125397
    Abstract: Engineered multivalent and multispecific binding proteins that bind immune cell receptors and/or autoantigens are provided, along with methods of making and uses in the prevention, diagnosis, prognosis and/or treatment of disease.
    Type: Application
    Filed: October 6, 2014
    Publication date: May 7, 2015
    Inventors: Chee-Ho Choi, Tariq Ghayur, Ann Marshak-Rothstein, Krishna Moody
  • Patent number: 9023637
    Abstract: Provided herein are fungi, such as Aspergillus niger, having a dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase (Alg3) gene genetic inactivation, increased expression of a loss of aflR expression A (Lae), or both. In some examples, such mutants have several phenotypes, including an increased production of citric acid relative to the parental strain. Methods of using the disclosed fungi to make citric acid are also provided, as are compositions and kits including the disclosed fungi.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: May 5, 2015
    Assignee: Battelle Memorial Institute
    Inventors: Ziyu Dai, Scott E. Baker
  • Publication number: 20150118725
    Abstract: Described is a method for generating isoprenol through a biological process. More specifically, described is a method for producing isoprenol from mevalonate.
    Type: Application
    Filed: April 4, 2013
    Publication date: April 30, 2015
    Inventors: Marc Delcourt, Maria Anissimova, Philippe Marliere
  • Publication number: 20150119608
    Abstract: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
    Type: Application
    Filed: December 30, 2014
    Publication date: April 30, 2015
    Inventors: Gail K. Donaldson, Andrew C. Eliot, Dennis Flint, Lori Ann Maggio-Hall, Vasantha Nagarajan
  • Publication number: 20150118721
    Abstract: The invention relates to novel enzymes that provide acetylated sphingoid bases.
    Type: Application
    Filed: March 13, 2013
    Publication date: April 30, 2015
    Applicant: EVONIK INDUSTRIES AG
    Inventors: Steffen Schaffer, Mike Farwick, Heiko Andrea, Tim Koehler, Daniel Wolff, Frank ter Veld, Ansgar Poetsch, Eckhard Boles, Christoph Schorsch
  • Publication number: 20150118184
    Abstract: A monoclonal antibody recognizing the extracellular region of LAMP5 was produced. The produced antibody demonstrated antibody-dependent cell-mediated cytotoxic activity, and/or cell growth inhibitory activity in the presence of a toxin-labeled secondary antibody, against a multiple myeloma cell line.
    Type: Application
    Filed: March 29, 2013
    Publication date: April 30, 2015
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventor: Shigeto Kawai
  • Patent number: 9017984
    Abstract: Genetically engineered microorganisms that produce fatty alcohols from a sugar source by way of the fatty acid biosynthetic pathway, as well as methods of their use are provided.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: April 28, 2015
    Assignee: REG Life Sciences, LLC
    Inventors: Zhihao Hu, Fernando Valle
  • Publication number: 20150111222
    Abstract: The present disclosure provides, inter alia, genetically encoded recombinant peptide biosensors comprising analyte-binding framework portions and signaling portions, wherein the signaling portions are present within the framework portions at sites or amino acid positions that undergo a conformational change upon interaction of the framework portion with an analyte.
    Type: Application
    Filed: August 8, 2012
    Publication date: April 23, 2015
    Applicant: HOWARD hUGHES MEDICAL INSTITUTE
    Inventors: Jonathan Marvin, Loren Looger, Richard T. Lee, Eric Schreiter