Candida Patents (Class 435/254.22)
  • PREPARATION OF ALPHA-KETOPIMELIC ACID
    Publication number: 20120231512
    Abstract: The present invention relates to a method for preparing alpha-ketopimelic acid, comprising converting 2-hydroxyheptanedioic acid into alpha-ketopimelic acid, which conversion is catalysed using a biocatalyst. Further, the invention relates to a heterologous cell, comprising a nucleic acid sequence encoding an enzyme having catalytic activity in the conversion of 2-hydroxyheptanedioic acid into alpha-ketopimelic acid. Further, the invention relates to the use of a heterologous cell according to the invention in the preparation of caprolactam, diaminohexane or adipic acid.
    Type: Application
    Filed: September 10, 2010
    Publication date: September 13, 2012
    Applicant: DSM IP ASSETS B.V.
    Inventors: Petronella Catharina Raemakers-Franken, Axel Christoph Trefzer, Linda Vermote
  • NOVEL FATTY ACID ELONGASE AND USES THEREOF
    Publication number: 20120233716
    Abstract: The present invention relates to nucleic acids derived from Sphaeroforma arctica. The invention also relates to the individual coding sequences and to proteins encoded by these sequences in combination with other sequences as well as to a process for converting oleic acid to linoleic acid to linoleic acid and the production of arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid in a plant.
    Type: Application
    Filed: November 23, 2010
    Publication date: September 13, 2012
    Applicant: BASF Plant Science Company GmbH
    Inventors: Jörg Bauer, Xiao Qiu, Patricia Vrinten
  • MICROBIAL PRODUCTION OF 3,4-DIHYDROXYBUTYRATE (3,4-DHBA), 2,3- DIHYDROXYBUTYRATE (2,3-DHBA) AND 3-HYDROXYBUTYROLACTONE (3-HBL)
    Publication number: 20120226055
    Abstract: The invention relates to recombinant cells and their use in the production of 3,4-dihydroxybutyrate, 2,3-dihydroxybutyrate and 3-hydroxybutyrolactone.
    Type: Application
    Filed: February 24, 2012
    Publication date: September 6, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Himanshu Hemant Dhamankar, Collin Hunter Martin, Kristala Lanett Jones Prather
  • METABOLIC ENGINEERING OF XYLOSE-FERMENTING EUKARYOTIC CELLS
    Publication number: 20120225451
    Abstract: The present invention relates to genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers on the host cell the ability to isomerize xylose to xylulose. These genetic modifications are aimed at improving the efficiency of xylose metabolism and include. e.g., reduction of nonspecific aldose reductase activity, increased xylulose kinase activity and increased flux of the pentose phosphate pathway. The modified host cells of the invention are suitable for the production of a wide variety of fermentation products, including ethanol, in fermentation processes in which a source of xylose or a source of xylose and glucose are used as carbon source.
    Type: Application
    Filed: September 2, 2011
    Publication date: September 6, 2012
    Applicant: Technische Universiteit Delft
    Inventors: Aaron Adriaan WINKLER, Sipko Maarten Kuyper, Wilhelmus Theodorus Antonius Maria De Laat, Johannes Pieter Van Dijken, Jacobus Thomas Pronk
  • MUTANT DELTA-9 ELONGASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS
    Publication number: 20120226062
    Abstract: Mutant delta-9 elongases having the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA] and/or ?-linolenic [18:3, ALA] to eicosatrienoic acid [20:3, ETrA] are disclosed herein. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding mutant delta-9 elongases, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”] using these mutant delta-9 elongases in oleaginous yeast are also disclosed.
    Type: Application
    Filed: August 26, 2011
    Publication date: September 6, 2012
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Michael W. Bostick, Hongxian He, Yougen Li, Quinn Qun Zhu
  • Polypeptides Having Glucoamylase Activity and Polynucleotides Encoding Same
    Publication number: 20120219989
    Abstract: The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: November 30, 2010
    Publication date: August 30, 2012
    Applicants: NOVOZYMES NORTH AMERICA, INC., NOVOZYMES A/S
    Inventors: Sara Landvik, Keiichi Ayabe, Guillermo Coward-Kelly
  • Polypeptides Having Glucoamylase Activity and Polynucleotides Encoding Same
    Publication number: 20120214197
    Abstract: The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: November 30, 2010
    Publication date: August 23, 2012
    Applicants: NOVOZYMES NORTH AMERICA, INC., NOVOZYMES A/S
    Inventors: Sara Landvik, Marc Dominique Morant, Keiichi Ayabe, Guillermo Coward-Kelly
  • Polypeptides Having Glucoamylase Activity And Polynucleotides Encoding Same
    Publication number: 20120214196
    Abstract: The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: November 30, 2010
    Publication date: August 23, 2012
    Applicants: NOVOZYMES NORTH AMERICA, INC., NOVOZYMES A/S
    Inventors: Sara Landvik, Marc Dominique Morant, Keiichi Ayabe, Guillermo Coward-Kelly
  • METABOLIC ENGINEERING OF ARABINOSE-FERMENTING YEAST CELLS
    Publication number: 20120208231
    Abstract: The invention relates to an eukaryotic cell expressing nucleotide sequences encoding the ara A, ara B and ara D enzymes whereby the expression of these nucleotide sequences confers on the cell the ability to use L-arabinose and/or convert L-arabinose into L-ribulose, and/or xylulose 5-phosphate and/or into a desired fermentation product such as ethanol. Optionally, the eukaryotic cell is also able to convert xylose into ethanol.
    Type: Application
    Filed: January 6, 2012
    Publication date: August 16, 2012
    Applicant: DSM IP ASSETS B.V.
    Inventors: Antonius Jeroen Adriaan VAN MARIS, Jacobus Thomas PRONK, Hendrik Wouter WISSELINK, Johannes Pieter VAN DIJKEN, Aaron Adriaan WINKLER, Johannes Hendrik DE WINDE
  • Biological methods for preparing adipic acid
    Patent number: 8241879
    Abstract: The technology relates in part to biological methods for producing adipic acid and engineered microorganisms capable of such production.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: August 14, 2012
    Assignee: Verdezyne, Inc.
    Inventors: Stephen Picataggio, Tom Beardslee
  • POLYPEPTIDES HAVING ENDOGLUCANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20120202266
    Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: April 5, 2012
    Publication date: August 9, 2012
    Applicants: Novozymes, Inc., Novozymes A/S
    Inventors: Paul Harris, Elena Vlasenko, Elizabeth Zaretsky, Marcus Sakari Kauppinnen
  • POLYPEPTIDE VARIANTS WITH ALTERED EFFECTOR FUNCTION
    Publication number: 20120202224
    Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
    Type: Application
    Filed: March 1, 2012
    Publication date: August 9, 2012
    Inventor: Leonard PRESTA
  • Compositions and Methods for Binding Lysophosphatidic Acid
    Publication number: 20120195901
    Abstract: Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described.
    Type: Application
    Filed: April 16, 2012
    Publication date: August 2, 2012
    Inventors: Roger A. SABBADINI, William A. GARLAND, Genevieve HANSEN, James Stephen SWANEY
  • DFPASE ENZYMES FROM APLYSIA CALIFORNICA
    Publication number: 20120195874
    Abstract: The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: May 6, 2010
    Publication date: August 2, 2012
    Applicant: NOVOZYMES A/S
    Inventors: Steffen Danielsen, Lars Kobberoee Skov, Ricardo Leite, Vincent Laize, M. Leonor Cancela Da Fonseca
  • Promoter Variants For Expressing Genes In A Fungal Cell
    Publication number: 20120190067
    Abstract: The present invention relates to methods for producing a biological substance, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the biological substance, wherein the fungal host cell comprises a first nucleic acid sequence encoding the biological substance operably linked to a second nucleic acid sequence comprising a promoter variant selected from the group consisting of SEQ ID NOs: 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, and 12; and a subsequence thereof; and hybrid and tandem promoters thereof; and (b) isolating the biological substance from the cultivation medium. The present invention also relates to the isolated promoter variants and to constructs, vectors, and fungal host cells comprising the promoter variants operably linked to nucleic acid sequences encoding biological substances.
    Type: Application
    Filed: March 19, 2012
    Publication date: July 26, 2012
    Applicant: Novozymes, Inc.
    Inventors: Debbie Yaver, Peter Nham
  • POLYPEPTIDES HAVING LIPASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20120192316
    Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: April 5, 2012
    Publication date: July 26, 2012
    Applicants: Novozymes A/S, Novozymes, Inc.
    Inventors: Debbie Yaver, Suzanne Otani, Janine Lin, Christopher Amolo, Kim Borch, Shamkant Anant Patkar, Michael Lamsa, Barbara Cherry
  • LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS
    Publication number: 20120190038
    Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and processes disclosed herein are designed so that fermentation facilities currently producing lovastatin can be converted to producing simvastatin and related compounds with minimal modifications.
    Type: Application
    Filed: October 8, 2010
    Publication date: July 26, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yi Tang, Xue Gao, Xinkai Xie
  • ENGINEERED MICROOGRANISMS CAPABLE OF PRODUCING TARGET COMPOUNDS UNDER ANAEROBIC CONDITIONS
    Publication number: 20120190089
    Abstract: The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention.
    Type: Application
    Filed: November 23, 2011
    Publication date: July 26, 2012
    Applicants: California Institute of Technology, Gevo, Inc.
    Inventors: Thomas Buelter, Peter Meinhold, Reid M. Renny Feldman, Andrew C. Hawkins, Sabine Bastian, Frances Arnold, Jun Urano
  • Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression
    Publication number: 20120185954
    Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
    Type: Application
    Filed: November 4, 2011
    Publication date: July 19, 2012
    Applicant: INTREXON Corporation
    Inventors: Subba Reddy PALLI, Mohan Basavaraju Kumar
  • POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20120185970
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: March 26, 2012
    Publication date: July 19, 2012
    Applicants: Novozymes, Inc., Novozymes A/S
    Inventors: Junxin Duan, Ye Liu, Lan Tang, Wenping Wu, Jason Quinlan, Randall Kramer
  • POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20120185971
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: March 29, 2012
    Publication date: July 19, 2012
    Applicants: Novozymes, Inc., Novozymes A/S
    Inventors: Lan Tang, Ye Liu, Junxin Duan, Yu Zhang, Christian Isak Jorgensen, Randall Kramer
  • STEROL SIDE CHAIN-CLEAVING ENZYME PROTEIN AND USE THEREOF
    Publication number: 20120178124
    Abstract: It is an object of the present invention to obtain highly active P450scc enzyme protein which is an important enzyme protein that catalyzes the first step of the biosynthesis of industrially useful steroid hormone. The present invention provides a sterol side chain cleavage enzyme protein having the following physicochemical properties: (1) action: the enzyme acts on sterol represented by formula (I) as defined in the specification and cleaves the carbon-carbon bond between positions 20 and 22 of a sterol side chain portion by its activity of cleaving the bonds, so as to generate a compound represented by formula (II) as defined in the specification; (2) substrate specificity: when microorganisms that produce the enzyme protein are allowed to react with an aqueous solution containing 100 ?g/ml 4-cholesten-3-one or cholesterol at 28° C.
    Type: Application
    Filed: January 7, 2009
    Publication date: July 12, 2012
    Applicant: MITSUBISHI CHEMICAL CORPORATION
    Inventors: Masahiro Yamagishi, Takeshi Sakamoto, Makoto Ueda, Masashi Itoh, Yoshikazu Fujii, Hiroki Kabumoto, Akira Arisawa, Tadashi Fujii
  • Xylitol Producing Microorganism Introduced with Arabinose Metabolic Pathway and Production Method of Xylitol Using the Same
    Publication number: 20120171739
    Abstract: The present invention relates to an efficient production method of xylitol by using the xylitol producing microorganism introduced with arabinose metabolic pathway to inhibit the production of arabitol, the byproduct, and instead to use arabinose only for cell metabolism in xylose/arabinose mixed medium. More precisely, to express efficiently L-arabinose isomerase (araA), L-ribulokinase (araB) and L-ribulose-5-phosphate 4-epimerase (araD) in Candida tropicalis, codon optimization was performed. Then, each gene was inserted in the gene expression cassette containing the glyceraldehyde-3-phosphate dehydrogenase promoter and the selection marker URA3, which was introduced into Candida sp. microorganism. As a result, arabitol, the byproduct interrupting the purification and crystallization of xylitol could be inhibited, making the production method of xylitol of the present invention more efficient.
    Type: Application
    Filed: January 18, 2011
    Publication date: July 5, 2012
    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Jung Hoe Kim, Byoung Hoon Yoon, Woo Young Jeon, Woo Yong Shim
  • ANTIBODIES TO HIGH MOLECULAR WEIGHT MELANOMA ASSOCIATED ANTIGEN
    Publication number: 20120171226
    Abstract: The present disclosure relates to anti-high molecular weight melanoma associated antigen (HMW-MAA) antibodies which bind to human HMW-MAA. Such antibodies may be used to treat diseases or disorders characterized by expression of HMW-MAA including cancer, for example, melanoma, basal cell carcinoma, ALL or AML.
    Type: Application
    Filed: July 16, 2010
    Publication date: July 5, 2012
    Applicant: XOMA Technology Ltd.
    Inventor: Arnold H. Horwitz
  • Polypeptides of Botryosphaeria Rhodina
    Publication number: 20120171189
    Abstract: The invention relates to functional polypeptides secreted from Botryospaeria rhodina CBS 274.96.
    Type: Application
    Filed: February 8, 2012
    Publication date: July 5, 2012
    Applicant: NOVOZYMES A/S
    Inventors: Kirk Matthew Schnorr, Lene Lange, Pernille Uldall Bolvig
  • COMBINATORIAL VARIANTS OF GLUCOAMYLASE WITH IMPROVED SPECIFIC ACTIVITY AND/OR THERMOSTABILITY
    Publication number: 20120164695
    Abstract: Presently provided are variant glucoamylases displaying altered properties, such as improved thermostability and/or specific activity. Also disclosed are DNA sequences coding for the variants, vectors and host cells incorporating the DNA sequence, enzyme compositions, and methods of using the variants in various applications.
    Type: Application
    Filed: August 18, 2010
    Publication date: June 28, 2012
    Applicant: DANISCO US INC.
    Inventors: Wolfgang Aehle, Richard R. Bott, Martijn Silvan Scheffers, Casper Vroeman
  • MICROORGANISM FOR EXPRESSING A HUMAN MEMBRANE PROTEIN
    Publication number: 20120156695
    Abstract: The invention relates to an isolated, genetically modified, living non-mammal organism, having increased HMG-CoA-reductase activity compared to the wild type, and having reduced C24-methyltransferase and/or delta22-desaturase activity compared to the wild type. The invention is characterized in that the organism has increased dehydrocholesterol-delta70-reductase activity compared to the wild type. The invention further relates to different uses of such an organism, to a test kit comprising such an organism, and to a membrane extract of such an organism.
    Type: Application
    Filed: April 1, 2010
    Publication date: June 21, 2012
    Applicant: ORGANOBALANCE GMBH
    Inventors: Michael Schilling, Christine Lang, Andreas Raab
  • BIOLOGICAL METHODS FOR PREPARING ADIPIC ACID
    Publication number: 20120156761
    Abstract: The technology relates in part to biological methods for producing adipic acid and engineered microorganisms capable of such production.
    Type: Application
    Filed: July 1, 2010
    Publication date: June 21, 2012
    Applicant: VERDEZYNE, INC.
    Inventors: Stephen Picataggio, Tom Beardslee
  • PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY
    Publication number: 20120156157
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Inventors: Robert DiCosimo, Mark Scott Payne, John Edward Gavagan
  • GENETICALLY MODIFIED ORGANISM FOR THE PRODUCTION OF LIPIDS
    Publication number: 20120156249
    Abstract: The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA: sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.
    Type: Application
    Filed: August 4, 2010
    Publication date: June 21, 2012
    Applicant: ORGANOBALANCE GMBH
    Inventors: Christine Lang, Andreas Raab
  • RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES
    Publication number: 20120156735
    Abstract: The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity.
    Type: Application
    Filed: June 15, 2011
    Publication date: June 21, 2012
    Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLC
    Inventors: Michael Dauner, Lori Ann Maggio-Hall, Jean-Francois Tomb
  • PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY
    Publication number: 20120156158
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Inventors: Robert DiCosimo, Mark Scott Payne, John Edward Gavagan
  • PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY
    Publication number: 20120156159
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Inventors: Robert DiCosimo, Mark Scott Payne, John Edward Gavagan
  • PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY
    Publication number: 20120156155
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Inventors: Robert Dicosimo, Mark Scott Payne, John Edward Gavagan
  • POLYPEPTIDES HAVING CELLOBIOHYDROLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20120156755
    Abstract: The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: February 27, 2012
    Publication date: June 21, 2012
    Applicant: Novozymes A/S
    Inventors: Suchindra Maiyuran, Paul Harris, Hanshu Ding, Kimberly Brown
  • PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY
    Publication number: 20120156156
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Inventors: Robert Dicosimo, Mark Scott Payne, John Edward Gavagan
  • METHODS AND COMPOSITIONS FOR PRODUCING LINEAR ALKYL BENZENES
    Publication number: 20120157717
    Abstract: Compositions and methods for producing hydrocarbons using recombinant cells are described herein. Also described herein are recombinant cells, recombinant cell cultures and methods for producing linear alkyl benzenes (LABs) using hydrocarbons produced by such recombinant cell cultures.
    Type: Application
    Filed: September 15, 2011
    Publication date: June 21, 2012
    Applicant: LS9, INC.
    Inventors: Mathew A. RUDE, Andreas W. SCHIRMER
  • GLUCOAMYLASE VARIANTS WITH ALTERED PROPERTIES
    Publication number: 20120149087
    Abstract: The present disclosure relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present disclosure provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions and cleaning compositions. The disclosure also relates to DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.
    Type: Application
    Filed: September 30, 2011
    Publication date: June 14, 2012
    Applicant: Danisco US Inc.
    Inventors: Wolfgang Aehle, Richard R. Bott, Martijn Scheffers, Piet Van Solingen, Casper Vroemen
  • Modified Leptin Polypeptides and Their Uses
    Publication number: 20120149636
    Abstract: Modified human leptin polypeptides and uses thereof are provided.
    Type: Application
    Filed: February 5, 2009
    Publication date: June 14, 2012
    Applicant: AMBRX, INC.
    Inventors: Vadim Kraynov, Anna-Maria A. Hays Putnam, Nick Knudsen, Jason Pinkstaff, Heather Myler, Lorraine Sullivan
  • Polypeptides Having Acetylxylan Esterase Activity And Polynucleotides Encoding Same
    Publication number: 20120149078
    Abstract: The present invention relates to isolated polypeptides having acetylxylan esterase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: March 1, 2012
    Publication date: June 14, 2012
    Applicant: NOVOZYMES A/S
    Inventors: Michelle Maranta, Kimberly Brown
  • Polypeptides having endoglucanase activity and polynucleotides encoding same
    Publication number: 20120151633
    Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: February 17, 2012
    Publication date: June 14, 2012
    Applicants: NOVOZYMES, INC., NOVOZYMES A/S
    Inventors: Søren Flensted Lassen, Paul Harris, Elena Vlasenko, Kristian Bertel Romer Morkeberg Krogh
  • METHOD FOR PREPARING AN INDUSTRIAL YEAST, INDUSTRIAL YEAST, AND APPLICATION TO THE PRODUCTION OF ETHANOL FROM AT LEAST ONE PENTOSE
    Publication number: 20120142067
    Abstract: The present invention relates to the field of the methods for obtaining yeast strains producing ethanol, of the thereby produced strains, and of the industrial production of ethanol from said strains. More particularly, the present invention describes in its most general aspect, a method for preparing yeasts from Saccharomyces cerevisiae strains by integration into the genome of the yeast of at least one gene coding for xylose isomerase and of at least one gene coding for xylitol dehydrogenase. The strain of the invention is useful for producing ethanol from a medium comprising at least one pentose, preferably xylose or a xylose and arabinose mixture.
    Type: Application
    Filed: December 2, 2011
    Publication date: June 7, 2012
    Applicant: LESAFFRE ET COMPAGNIE
    Inventors: Thomas DESFOUGERES, Georges PIGNEDE
  • METHOD FOR THE PRODUCTION OF VARIABLE DOMAINS
    Publication number: 20120141460
    Abstract: The present invention provides methods for the expression and/or production of variable domains with a C-terminal extension that can be used for coupling of the variable domain to one or more further groups, residues or moieties. In the method of the invention a yield of at least 80% of variable domains with a cysteine containing C-terminal extension is obtained. Also variable domains are provided and polypeptides comprising one or more variable domains obtainable by the methods of the present invention, as well as compounds that comprise such variable domains and/or polypeptides coupled to one or more groups, residues or moieties.
    Type: Application
    Filed: July 9, 2010
    Publication date: June 7, 2012
    Applicant: Ablynx N.V.
    Inventors: Hilde Stals, Veronique De Brabandere, Peter Schotte
  • Yeast Cells Expressing An Exogenous Cellulosome And Methods of Using The Same
    Publication number: 20120142046
    Abstract: The present invention relates to the engineering and expression of heterologous cellulosomes in microorganisms in order to facilitate the conversion of biomass to useful products. In some embodiments, the invention relates to the expression of scaffoldin proteins which form the nucleus of a cellulosome. Cellulases or other biomass-degrading enzymes can be non-covalently linked to the scaffoldin protein by virtue of a dockerin domain-cohesin domain interaction.
    Type: Application
    Filed: February 18, 2010
    Publication date: June 7, 2012
    Inventors: John McBride, Mark Mellon, Vineet Rajgarhia, Elena E. Brevnova, Erin Wiswall, David A. Hogsett, Danie LaGrange, Shaunita Rose, Emile Van Zyl
  • Producing Itaconic acid in yeast using glycerol as the substrate
    Patent number: 8192965
    Abstract: Method for producing itaconic acid in yeast cells using glycerol as the substrate. The yeast cells express cis-aconitic acid decarboxylase and optionally, citrate synthase and/or aconitase at high levels.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: June 5, 2012
    Assignee: Industrial Technology Research Institute
    Inventors: Jia-Hung Wang, Shu-Hsien Tsai, Kelly Teng
  • COMPOSITIONS AND METHODS FOR USING MULTISPECIFIC-BINDING PROTEINS COMPRISING AN ANTIBODY-RECEPTOR COMBINATION
    Publication number: 20120134993
    Abstract: Disclosed are bispecific binding proteins comprising a antibody/soluble receptor bispecific binding protein that reduces the biological activity of both VEGF-A and FGF. The FGF binding moieties are generally soluble FGFR3 or FGFR2. An Fc polypeptide is fused to the C-terminus of the FGF binding moiety and VEGF-A binding moiety are polypeptides fused using peptide or polypeptide linker sequences, and can be expressed as single bispecific binding protein. The bispecific antibody/soluble receptor binding proteins can be used to treat cancers characterized by solid tumor growth as well as other diseases.
    Type: Application
    Filed: March 26, 2010
    Publication date: May 31, 2012
    Inventors: Qi Pan, Carl W. Birks, Pallavur V. Sivakumar
  • Compositions and methods for 3-hydroxypropionic acid production
    Publication number: 20120135481
    Abstract: The present application discloses genetically modified yeast cells comprising an active 3-HP fermentation pathway, and the use of these cells to produce 3-HP.
    Type: Application
    Filed: November 21, 2011
    Publication date: May 31, 2012
    Applicant: NOVOZYMES, INC.
    Inventors: Holly Jessen, Brian Rush, Jeanette Huryta, Beth Mastel, Alan Berry, Debbie Yaver, Michael Catlett, Michelle Barnhart
  • Methods of Treatment Using CCA1 Inhibitors
    Publication number: 20120135453
    Abstract: Provided herein are methods for the treatment or prevention of a fungal infection in a host comprising the administration to the host a therapeutically or prophylactically effective amount of a CCA1 inhibitor.
    Type: Application
    Filed: May 26, 2011
    Publication date: May 31, 2012
    Applicant: UCB Pharma SA
    Inventor: Katherine Ann Vousden
  • Genetically Modified Yeast of the Species Issatchenkia Orientalis and Closely Related Species, and Fermentation Processes Using Same
    Publication number: 20120129230
    Abstract: Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
    Type: Application
    Filed: December 9, 2011
    Publication date: May 24, 2012
    Inventors: Pirkko Suominen, Aristos Aristidou, Merja Penttila, Marja Ilmen, Laura Ruohonen, Kari Koivuranta, Kevin Roberg-Perez
  • NOVEL FATTY ACID DESATURASES AND ELONGASES AND USES THEREOF
    Publication number: 20120124705
    Abstract: The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA).
    Type: Application
    Filed: July 15, 2010
    Publication date: May 17, 2012
    Applicant: BASF Plant Science Company GMBH
    Inventors: Jörg Bauer, Johnathan A. Napier, Olga Sayanova