Penicillium Patents (Class 435/254.5)
-
Publication number: 20130344573Abstract: The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal peptide and a second nucleotide sequence encoding a polypeptide which is foreign to the first nucleotide sequence. Furthermore, it also relates to expression vectors and host cells comprising the nuclei acid construct.Type: ApplicationFiled: August 16, 2013Publication date: December 26, 2013Applicant: NOVOZYMES A/SInventors: Tomoko Matsui, Henriette Draborg, Steffen Danielsen
-
Publication number: 20130330780Abstract: The present disclosure relates to recombinant proteins having N-acetylglucosaminyltransferase activity. The present disclosure further relates to methods for producing complex N-glycans including the steps of providing host cells containing such recombinant proteins and culturing the host cells such that the recombinant proteins are expressed.Type: ApplicationFiled: November 24, 2010Publication date: December 12, 2013Inventors: Jari Natunen, Anne Kanerva, Jukka Hiltunen, Markku Saloheimo, Heli Viskari, Anne Huuskonen
-
Publication number: 20130333072Abstract: The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 30, 2010Publication date: December 12, 2013Applicants: Novozymes North America, Inc., Novozymes A/SInventors: Sara Landvik, Keiichi Ayabe, Guillermo Coward-Kelly
-
Publication number: 20130330784Abstract: The invention relates to temperature-stable polypeptides with ?-pyranosidase activity. The polypeptide substrates include ?-glucopyranosides und ?-xylopyranosides. Said polypeptides can be expressed alone or as fusion proteins for example in yeast or bacteria and subsequently purified. The polypeptides according to said invention can be used alone or in a mixture with other enzymes for the degradation of plant raw materials, among others for the enzymatic degradation of biomass containing lignocellulose, in particular hemicellulose and the hemicellulose component xylan. Said enzymes are suitable for use in textile processing, as an additive of detergents, or in the food or feed industry.Type: ApplicationFiled: October 26, 2011Publication date: December 12, 2013Applicant: CLARIANT PRODUKTE (DEUTSCHLAND) GMBHInventors: Christoph Reisinger, Farah Qoura, Barbara Klippel, Garabed Antranikian
-
Publication number: 20130315918Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.Type: ApplicationFiled: June 27, 2013Publication date: November 28, 2013Applicant: Genentech, Inc.Inventors: GERMAINE FUH, HANS-PETER GERBER, WEI-CHING LIANG, FREDERIC FELLOUSE, SACHDEV S. SIDHU, CHRISTIAN WIESMANN
-
Publication number: 20130309726Abstract: The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.Type: ApplicationFiled: June 30, 2011Publication date: November 21, 2013Applicant: DUPONT NUTRITION BIOSCIENCES APSInventors: Peter Edvard Degn, Richard R. Bott, Casper Willem Vroemen, Martijn Silvan Scheffers, Wolfgang Aehle, Elin Petersen
-
Publication number: 20130309751Abstract: The present invention relates to isolated polypeptides having phospholipase C activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 9, 2011Publication date: November 21, 2013Applicant: Novozymes A/SInventors: Lan Tang, Ye Liu, Kim Borch, Jesper Brask
-
Publication number: 20130309752Abstract: The present disclosure generally relates to polypeptides having colanic acid-degrading activity and methods of using the same. Polynucleotides encoding such polypeptides are also described. The polypeptides may be used, for example, in processes for degrading colanic acid, processes for the removal of endotoxins from biological samples, and processes for purifying plasmid DNA.Type: ApplicationFiled: July 30, 2013Publication date: November 21, 2013Applicant: GRADALIS, INC,Inventor: Nancy Smyth Templeton
-
Publication number: 20130291230Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: June 7, 2013Publication date: October 31, 2013Inventors: Alfredo Lopez de Leon, Michael Rey
-
Publication number: 20130288299Abstract: The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: January 26, 2012Publication date: October 31, 2013Applicant: Novozymes Inc.Inventor: Nikolaj Spodsberg
-
Publication number: 20130288310Abstract: The invention relates to C1 lignocellulose degradation enzyme nucleic acid and protein sequences and expression of recombinant C1 lignocellulose degradation enzymes. The invention provides methods for degrading a cellulosic biomass by contacting the biomass with a recombinant C1 lignocellulose degradation enzyme of the invention.Type: ApplicationFiled: August 22, 2011Publication date: October 31, 2013Applicant: Codexis, IncInventors: Louis Clark, Dipnath Baidyaroy
-
Publication number: 20130288301Abstract: The present invention relates to isolated polypeptides having endoglucanase activity, catalytic domains, cellulose binding domains and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or cellulose binding domains.Type: ApplicationFiled: January 26, 2012Publication date: October 31, 2013Inventors: Nikolaj Spodsberg, Tarana Shagasi
-
Publication number: 20130288303Abstract: This invention relates to compositions and methods for treating c-Kit associated disorders such as fibrosis, and more particularly, to compositions containing humanized c-Kit antibodieType: ApplicationFiled: May 6, 2013Publication date: October 31, 2013Inventors: Gordon NG, Wenyan Shen
-
Publication number: 20130280764Abstract: The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: Chrysosporium, Thielavia, Talaromyces, Thermomyces, Thermoascus, Neurospora, Aureobasidium, Filibasidium, Piromyces, Corynascus, Cryplococcus, Acremonium, Tolypocladium, Scytalidium, Schizophyllum, Sporotrichum, Penicillium, Gibberella, Myceliophthora, Mucor, Aspergillus, Fusarium, Humicola, Trichoderma, and Talaromyces, plus anamorphs and teleomorphs thereof.Type: ApplicationFiled: April 19, 2013Publication date: October 24, 2013Applicant: DYADIC INTERNATIONAL (USA) LTD.Inventors: Mark EMALFARB, Arkady SINITSYN, Richard JUNDZIL, Jan WERY, Jacob VISSER, Rob JOOSTEN, Martijn KOETSIER
-
Publication number: 20130273632Abstract: To provide novel ?-amylase derived from a microorganism and a gene thereof. ?-amylase derived from Bacillus flexus is provided.Type: ApplicationFiled: June 17, 2013Publication date: October 17, 2013Inventors: Akiko Matsunaga, Hitoshi Amano, Shotaro Yamaguchi
-
Publication number: 20130267002Abstract: The present invention relates to polypeptides having glucoamylase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: June 12, 2013Publication date: October 10, 2013Inventors: Sara Landvik, Marc Dominique Morant, Keiichi Ayabe, Guillermo Coward-Kelly
-
Publication number: 20130260420Abstract: The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: January 26, 2012Publication date: October 3, 2013Inventors: Marc D. Morant, Paul Harris
-
Publication number: 20130244292Abstract: The present invention relates to a family 5 glycoside hydrolase variant having endoglucanase activity, polynucleotides encoding the family 5 glycoside hydrolase variant, vectors, host cells comprising the polynucleotides, and methods for using the family 5 glycoside hydrolase variant.Type: ApplicationFiled: March 15, 2013Publication date: September 19, 2013Applicant: BP Corporation North America Inc.Inventors: John Poland, Justin T. Stege
-
Publication number: 20130243783Abstract: The present invention relates to humanized antibodies that specifically bind to CXCR5 and can, for example, inhibit CXCR5 function. The invention also includes uses of the antibodies to treat or prevent CXCR5 related diseases or disorders.Type: ApplicationFiled: March 11, 2013Publication date: September 19, 2013Applicant: SANOFIInventors: Renata Lee, Vincent Mikol, Elizabeth Allen, Norman Ruetsch, Beatrice Cameron, Thomas Oligino, Nicholas Baurin
-
Publication number: 20130244276Abstract: The present invention relates to a method for genetically modifying a filamentous fungus host for improved protein production. The method comprises that a filamentous fungus host is genetically modified to be deficient or to overexpress specific genes. The invention relates also to the modified hosts. Furthermore, the invention relates to a method for improved production or for producing an improved composition of proteins, such as cellulases, hemicellulases, other proteins involved in the degradation of lignocellulosic material, or other proteins, in a filamentous fungus host.Type: ApplicationFiled: May 30, 2011Publication date: September 19, 2013Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTTInventors: Tiina Pakula, Markku Saloheimo, Mari Hakkinen, Ann Westerholm-Parvinen, Merja Penttila, Marika Vitikainen
-
Publication number: 20130244289Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.Type: ApplicationFiled: January 17, 2013Publication date: September 19, 2013Applicant: DANISCO US INC.Inventors: Frits GOEDEGEBUUR, Peter GUALFETTI, Colin MITCHINSON, Edmund LARENAS
-
Publication number: 20130236471Abstract: The present invention relates to anti-IL-36R binding compounds, in particular new anti-IL-36R antibodies and therapeutic and diagnostic methods and compositions for using the same.Type: ApplicationFiled: November 14, 2012Publication date: September 12, 2013Applicant: Boehringer Ingelheim GmbHInventors: Su-Ellen BROWN, Keith Canada, Lukasz Chlewicki, Michael Howell, Detlev Mennerich, Joseph Robert Woska, JR.
-
Publication number: 20130227748Abstract: The present invention relates to polypeptide having cellulolytic enhancing activity variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.Type: ApplicationFiled: September 29, 2011Publication date: August 29, 2013Applicant: Novozymes, Inc.Inventors: Matt Sweeney, Mark Wogulis
-
Publication number: 20130217079Abstract: The present invention relates to variants of a parent beta-glucosidase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.Type: ApplicationFiled: September 30, 2011Publication date: August 22, 2013Applicant: Novozymes, Inc.Inventors: Mark Wogulis, Paul Harris, David Osborn
-
Publication number: 20130219571Abstract: The invention relates to a polypeptide comprising the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 73% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 73% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional polypeptide and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.Type: ApplicationFiled: June 23, 2011Publication date: August 22, 2013Applicant: DSM IP ASSETS B.V.Inventors: Margot Elisabeth Francoise Schoonneveld-Bergmans, Wilbert Herman Marie Heijne, Monica D. Vlasie, Robbertus Antonius Damveld
-
Publication number: 20130212745Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: August 30, 2011Publication date: August 15, 2013Applicants: NOVOYZMES A/S, NOVOZYMES, INC.Inventor: Nikolaj Spodsberg
-
Publication number: 20130210087Abstract: The present invention provides isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 4, 2011Publication date: August 15, 2013Applicant: NOVOZYMES INC.Inventors: Ye Liu, Lan Tang
-
Publication number: 20130212746Abstract: The present invention relates to isolated polypeptides having hemicellulolytic activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: August 30, 2011Publication date: August 15, 2013Applicants: NOVOYZMES A/S, NOVOZYMES, INC.Inventors: Nikolaj Spodsberg, Mary Stringer, Hanshu Ding
-
Publication number: 20130203128Abstract: In alternative embodiments, the invention provides polypeptides having a lignocellulolytic (lignocellulosic) activity, e.g., a ligninolytic and cellulolytic activity, including, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase (cbhl) (e.g., an exo-cellobiohydrolase, e.g., having an “exo” activity that can processively release cellobiose units ?-1,4 glucose-glucose disaccharide), a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a (?-xylosidase) and/or an arabinofuranosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides and nucleic acids of the invention are used in a variety of pharmaceutical, agricultural and industrial contexts; for example, as enzymes for the bioconversion of a biomass, e.g.Type: ApplicationFiled: October 6, 2011Publication date: August 8, 2013Applicant: BP Corporation North America Inc,Inventors: Justin T. Stege, Alexander Varvak, John Poland, Chris S. Lyon, Shaun Healey, Peter Luginbuhl
-
Publication number: 20130203126Abstract: The present invention relates to alpha-amylases, nucleic acids encoding the alpha-amylases, methods of producing the alpha-amylases, and methods of using the alpha-amylases.Type: ApplicationFiled: April 5, 2013Publication date: August 8, 2013Applicant: NOVOZYMES A/SInventor: NOVOZYMES A/S
-
Publication number: 20130196387Abstract: The present invention provides isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cell comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 11, 2011Publication date: August 1, 2013Applicant: Novozymes Inc.Inventors: Ye Liu, Junxin Duan, Lan Tang
-
Publication number: 20130189751Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.Type: ApplicationFiled: January 9, 2013Publication date: July 25, 2013Applicant: Genomatica, Inc.Inventors: Robert HASELBECK, John D. TRAWICK, Wei NIU, Anthony P. BURGARD
-
Publication number: 20130189283Abstract: Disclosed is an isolated immunoglobulin. Also disclosed are pharmaceutical compositions and medicaments comprising the immunoglobulin, isolated nucleic acid encoding it, vectors, host cells, useful in methods of making it. In some embodiments the immunoglobulin comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.Type: ApplicationFiled: September 22, 2011Publication date: July 25, 2013Applicant: AMGEN INC.Inventors: Kenneth W. Walker, Frederick W. Jacobsen, Taruna Arora
-
Publication number: 20130189733Abstract: The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype.Type: ApplicationFiled: January 25, 2013Publication date: July 25, 2013Applicant: DSM IP ASSETS B.V.Inventors: CORNELIS MARIA JACOBUS SAGT, CORNELIS THEODORUS VERRIPS, WALRAVEN HENRY MULLER, NOEL NICOLAAS MARIA ELISABETH VAN PEIJ
-
Publication number: 20130177947Abstract: The present disclosure is generally directed to glycosyl hydrolase enzymes, compositions comprising such enzymes, and methods of using the enzymes and compositions, for example for the saccharification of cellulosic and hemicellulosic materials into sugars.Type: ApplicationFiled: September 22, 2010Publication date: July 11, 2013Applicant: DANISCO US INC.Inventors: Benjamin Bower, Megan Yee Hsi, Thijs Kaper, Bradley R. Keleman, Suzanne E. Lantz, Edmund A. Larenas, Colin Mitchinson, Steven Kim, William D. Hitz, Mark Emptage, Keith Dumont Wing
-
Publication number: 20130180013Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: August 30, 2011Publication date: July 11, 2013Applicants: NOVOYZMES A/S, NOVOZYMES, INC.Inventor: Nikolaj Spodsberg
-
Patent number: 8481320Abstract: The present invention relates to methods for increasing homologous recombination of a nucleic acid sequence introduced into a host cell, comprising: (a) introducing into a population of filamentous fungal host cells a first nucleic acid sequence encoding a recombination protein and a second nucleic acid sequence comprising one or more regions which are homologous with the genome of the filamentous fungal host cell, wherein (i) the recombination protein promotes the recombination of the one or more regions with the corresponding homologous region in the host's genome to incorporate the second nucleic acid sequence by homologous recombination, and (ii) the number of host cells comprising the incorporated second nucleic acid sequence in the population is increased at least 20% compared to the same population without the first nucleic acid sequence; (b) and isolating from the population a filamentous fungal cell comprising the incorporated second nucleic acid sequence.Type: GrantFiled: December 10, 2012Date of Patent: July 9, 2013Assignee: Novozymes, Inc.Inventors: Paul Harris, Howard Brody
-
Publication number: 20130171718Abstract: The present disclosure relates to ?-class carbonic anhydrase polypeptides having improved properties including increased thermostability and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides formulations and uses of the polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering. Also provided are polynucleotides encoding the carbonic anhydrase polypeptides and host cells capable of expressing them.Type: ApplicationFiled: December 20, 2012Publication date: July 4, 2013Applicant: CODEXIS, INC.Inventor: Codexis, Inc.
-
Publication number: 20130171698Abstract: The present invention relates to a method of removing an intron contained in a gene from a eukaryotic gene, and linking only the exon sequences to prepare an expression vector comprising the linked sequences. Specifically, the invention relates to a method of preparing an expression vector containing linked exon sequences comprising amplifying exon sequences by PCR as one or more fragments from a giant fungal gene containing an intron, and linking the fragments together with a restriction enzyme-treated vector using the gap repair cloning method; a method of preparing an expression vector containing a full-length cDNA sequence by synthesizing and linking cDNA fragments from a fungal giant gene; a transformant having introduced therein an expression vector prepared by the method; a protein produced by the transformant; and a method of preparing a compound produced by the protein using the expression vector.Type: ApplicationFiled: August 11, 2011Publication date: July 4, 2013Inventors: Kenji Watanabe, Hisao Moriya
-
Publication number: 20130152234Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: ApplicationFiled: February 7, 2013Publication date: June 13, 2013Applicants: NOVOZYMES A/S, NOVOZYMES, INC.Inventors: Novozymes, Inc., Novozymes A/S
-
Publication number: 20130149742Abstract: The present disclosure relates to filamentous fungal host strains and recombinant DNA constructs for creation and use thereof. The filamentous fungal host strains are particularly useful for achieving reliable expression of recombinant enzymes and variants.Type: ApplicationFiled: June 3, 2011Publication date: June 13, 2013Applicant: Danisco US Inc.Inventors: Benjamin S. Bower, Thijs Kaper, Bradley R. Kelemen
-
Publication number: 20130144034Abstract: The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.Type: ApplicationFiled: July 1, 2011Publication date: June 6, 2013Applicant: DSM IP ASSETS B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Marcus Hans, Martina Beishuizen, Dick Schipper, Robertus Antonius Mijndert Van Der Hoeven, Olaf Leonardus Schouten
-
Publication number: 20130142788Abstract: The present invention relates to humanised antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such humanised antigen binding proteins in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.Type: ApplicationFiled: June 2, 2011Publication date: June 6, 2013Inventors: Claire Ashman, Stephen Ashman, Paul Andrew Hamblin, Alan Peter Lewis, Martin Anibal Orecchia
-
Publication number: 20130145501Abstract: The invention relates to a polypeptide having carbohydrate material degrading activity which comprises the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO: 4, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 96% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 96% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.Type: ApplicationFiled: April 23, 2010Publication date: June 6, 2013Applicant: DSM IP ASSETS B.V.Inventors: Cornelis Maria Jacobus Sagt, Margot Elisabeth Francoise Schooneveld-Bergmans, Johannes Andries Roubos, Alrik Pieter Los
-
Publication number: 20130143301Abstract: The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants.Type: ApplicationFiled: November 19, 2010Publication date: June 6, 2013Applicant: Danisco US Inc.Inventors: Richard R. Bott, Thijs Kaper, Bradley Kelemen, Frits Goedegebuur, Ronaldus Hommes, Slavko Kralj, Paulien Kruithof, Igor Nikolaev
-
Publication number: 20130143291Abstract: The present invention relates to methods for producing monoterpenes, particularly tricyclene, by culturing microbial organisms that express a terpene synthase and optionally a prenyl transferase.Type: ApplicationFiled: March 30, 2011Publication date: June 6, 2013Applicant: Codexis, Inc.Inventors: Robert McDaniel, Galit Meshulam-Simon, Oscar Alvizo, Xiyun Zhang
-
Publication number: 20130137152Abstract: The present invention relates to isolated polypeptides having glucoamylase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains.Type: ApplicationFiled: November 28, 2012Publication date: May 30, 2013Applicants: Novozymes North America, Inc., Novozymes A/SInventors: Novozymes A/S, Novozymes North America, Inc.
-
Publication number: 20130130330Abstract: A novel glycosyl hydrolase with activities of beta-xylosidase and beta-glucosidase is provided. Said glycosyl hydrolase can convert 7-xylosyltaxane compounds to 7-hydroxyltaxane compounds.Type: ApplicationFiled: April 12, 2011Publication date: May 23, 2013Applicant: INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF ME SCIENCESInventors: Ping Zhu, Haili Cheng, Ruiyu Zhao, Kedi Cheng, Huixia He, Chao Meng, Huixin Zhu
-
Publication number: 20130130325Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 16, 2012Publication date: May 23, 2013Applicants: NOVOZYMES, INC., NOVOZYMES A/SInventors: Novozymes A/S, Novozymes, Inc.
-
Publication number: 20130130327Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 16, 2012Publication date: May 23, 2013Applicants: NOVOZYMES, INC., NOVOZYMES A/SInventors: Novozymes A/S, Novozymes, Inc.