Collagen Or Gelatin Patents (Class 435/273)
  • Patent number: 9447169
    Abstract: The invention relates to hemostatic compositions and methods for promoting hemostasis. The invention also relates to hemostatic compositions and methods for promoting wound healing. In various embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the ratio of weight percent collagen solids to weight percent crosslinker when crosslinking the collagen. In other embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the temperature and rate of freezing when drying the composition during fabrication. In some embodiments, the compositions contain additional agents, including biological agents.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: September 20, 2016
    Assignee: Orthovita, Inc.
    Inventors: Marissa M. Darmoc, Lauren S. Brown, Jenny E. Raynor, Alice Chou, Abigail Cohen
  • Patent number: 9125856
    Abstract: Disclosed are compounds and related methods useful for cross-linking collagen and stabilizing collagenous tissues using formaldehyde-donating compounds or nitrogen oxide-containing compounds such as ?-Nitro Alcohols. Also disclosed are compounds and related methods for modulating the rate or degree of collagen cross-linking using nitrogen oxide-containing compounds such as ?-Nitro Alcohols. The formaldehyde-donating, nitrogen oxide-containing and/or ?-Nitro Alcohol compounds disclosed are capable of stabilizing collagenous tissues such as the corneal and scleral tissues and are useful in the treatment or prevention of diseases such as alterations in corneal curvature, keratoconus, keratectasia, progressive myopia and glaucoma.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: September 8, 2015
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: David Choohyun Paik, Stephen Trokel
  • Patent number: 8921312
    Abstract: Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: December 30, 2014
    Assignee: University of South Florida
    Inventors: Kurt Musselmann, John R. Hassell, Brad Kane, Bridgette Alexandrou
  • Publication number: 20140377833
    Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix. The methods can comprise treatment with alcalase under conditions controlled to produce a desired pliability without unacceptable alteration in collagen structure.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Inventors: Yi Chen, Kai-Roy Wang, Patrick Leamy, Hui Xu
  • Publication number: 20140363418
    Abstract: A method of producing collagen from hydrolyzed egg membrane includes combining 95% alcohol, cold water, a bacterial neutralase and/or alcalase, 14L, sodium bisulfite, and egg membrane. Once combined the solution is mixed slowly and then heated to a desired pH range. Once a desired temperature is reached, the heated solution is set aside to digest for a prolonged period of time. Next, the digested solution is centrifuged and filtered. Finally, the filtered solution is spray dried and packaged.
    Type: Application
    Filed: June 10, 2013
    Publication date: December 11, 2014
    Inventor: Robert den Hoed
  • Publication number: 20140147400
    Abstract: The present invention relates to the use of fish skin as novel industrial source of collagen. Advantageously, said skin is obtained after the filleting or cutting of the fresh fish and frozen immediately after filleting/cutting, thus guaranteeing a very good quality of the base material, both from the bacteriological standpoint and from the standpoint of the native property of the protein.
    Type: Application
    Filed: January 31, 2014
    Publication date: May 29, 2014
    Inventors: Jamilah Bakar, Umi H. Razali, Dzulkifly M. Hashim, Awis Q. Sazili, Kaur Harvinder
  • Patent number: 8642303
    Abstract: A process for the production of ethanol wherein a hydrolyzed lignocellulosic biomass is fermented in the presence of a stillage residue. The fermentation of cellulosic hydrolysates is improved by adding prior to and/or during fermentation a stillage residue side stream from a corn starch-to-ethanol process as a nutrient source for the yeast organisms used in the fermentation. Stillage residues from the grain dry mill ethanol producing process, including the whole stillage, wet cake, thin stillage, and/or syrup are added to assist as a nitrogen and nutrient source for the fermentive processes. The stillage residue is produced by any grain-to-ethanol process.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: February 4, 2014
    Assignee: GreenField Specialty Alcohols Inc.
    Inventors: Robert Ashley Cooper Benson, Regis-Olivier Benech
  • Patent number: 8586345
    Abstract: The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: November 19, 2013
    Assignee: Virginia Commonwealth University Intellectual Property Foundation
    Inventors: David G. Simpson, Gary L. Bowlin, Gary E. Wnek, Peter J. Stevens, Marcus E. Carr, Jamil A. Matthews, Saravanamoorthy Rajendran
  • Publication number: 20130267465
    Abstract: A process for the manufacture of a collagenous material from a plurality of collagen particles is described. The collagen particles are derived from a natural tissue material, are substantially free of non-fibrous tissue proteins, cellular elements and lipids or lipid residues, and comprise fragments of collagen fibres displaying original collagen fibre architecture and molecular ultrastructure of the natural tissue material. The process comprises the step of freeze drying the collagen particles in suspension in a freeze-drying suspension medium.
    Type: Application
    Filed: July 21, 2011
    Publication date: October 10, 2013
    Applicant: TISSUE SCIENCE LABORATORIES LIMITED
    Inventors: Paul Armitage, Christine Elizabeth Dawson
  • Patent number: 8470354
    Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: June 25, 2013
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: William F. McKay, Scott D. Boden, Neil B. Beals
  • Patent number: 8450100
    Abstract: A collagen peptide with immune-enhancing activity from Cyanea nozakii, and a preparation method thereof are provided. The collagen peptide contains 80-90 wt % of proteins and 10-20 wt % of sugars, and has an average molecular weight of 1,000-3,000 Dalton. Monosaccharide contained in the collagen peptide are mainly glucose, glycine accounts for 16% or above and the sum of proline and hydroxyproline accounts for 18% or above of amino acids contained therein. The collagen peptide is capable of being used for preparation of medicines, health products, and skincare cosmetics having immune-enhancing function.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: May 28, 2013
    Assignees: Jiangnan University
    Inventors: Luhong Tang, Bentian Zhang, Chao Deng, Dan Lin, Qi Wang, Wei Chen
  • Publication number: 20130123468
    Abstract: A method for extracting water-soluble undenatured type II collagen having an active epitope comprises a first step for extracting animal-derived cartilage using an acidic solution at 50° C. or less, and a second step for adding pepsin to the acidic solution and performing extraction at 40° C. or less. This allows the epitope of undenatured type II collagen to be extracted in large quantities and with high efficiency without any loss of activity, and makes it possible to provide a food or beverage product obtained using the water-soluble undenatured type II collagen extracted by the extraction method.
    Type: Application
    Filed: July 14, 2011
    Publication date: May 16, 2013
    Inventors: Hiroyoshi Moriyama, Orie Yoshinari, Yoshiaki Shiojima
  • Patent number: 8409622
    Abstract: A process for producing a biocompatible material includes the steps of mixing an extract of a fish scale-derived hydroxyapatite (with water content of 70 to 75% by weight) and of a fish scale-derived collagen (with water content of 40 to 60% by weight) in the weight percent ratio of about 8:2, stirring the mixture and drying the mixture by a hot blast in order to obtain a composite.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: April 2, 2013
    Assignee: RBS Co., Ltd.
    Inventor: Yoshiaki Okada
  • Patent number: 8241671
    Abstract: In order to provide a biocompatible material consisting mainly of a fish scale-derived hydroxyapatite and a fish scale-derived collagen, which is adjusted so that easily digested and absorbed in a human body, the material contains a composite consisting mainly of a fish scale-derived hydroxyapatite and a fish scale-derived collagen.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: August 14, 2012
    Assignee: RBS Co., Inc.
    Inventor: Yoshiaki Okada
  • Patent number: 8211487
    Abstract: Antifreeze polypeptides, antifreeze compositions including the polypeptides, nucleotides encoding the antifreeze polypeptides, methods of making antifreeze compositions, and methods of inhibiting ice crystal growth are provided herein. The peptides are based on the primary sequence of collagen and include those having a molecular weight between about 500-7000 Da. The peptides preferably include cationic polypeptides. The methods of making antifreeze compositions include digesting collagen or gelatin into hydrolysates with peptides having molecular weights between about 500-7000 Da. The digestions are performed with proteases and/or non-enzymatic hydrolysis. The methods of inhibiting ice crystal growth include adding the antifreeze polypeptides or compositions described herein to a composition to be frozen. The methods may be used to inhibit ice crystal growth in frozen food products.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: July 3, 2012
    Inventor: Srinivasan Damodaran
  • Publication number: 20120114570
    Abstract: The present invention relates to the use of fish skin as novel industrial source of collagen. Advantageously, said skin is obtained after the filleting or cutting of the fresh fish and frozen immediately after filleting/cutting, thus guaranteeing a very good quality of the base material, both from the bacteriological standpoint and from the standpoint of the native property of the protein.
    Type: Application
    Filed: June 13, 2011
    Publication date: May 10, 2012
    Inventors: Jamilah Bakar, Umi Hartina Mohamad Razali, Dzulkifly Mat Hashim, Awis Qurni Sazili, Harvinder Kaur, Russly Abdul Rahman, Badlishah Sham Baharin, Kaur Harvinder
  • Patent number: 8114669
    Abstract: A method for determining the effect of a plurality of culture conditions on a cell, comprising the steps of: a) providing a first set of groups of cell units each comprising one or more cells, and exposing said groups to desired culture conditions; (b) pooling two or more of said groups to form at least one second pool; (c) subdividing the second pool to create a further set of groups of cell units; (d) exposing said further groups to desired culture conditions; (e) optionally, repeating steps (b)-(d) iteratively as required; and (f) optionally assessing the effect on a given cell unit of the culture conditions to which it has been exposed.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: February 14, 2012
    Assignee: Plasticell Limited
    Inventor: Yen Choo
  • Patent number: 8092823
    Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: January 10, 2012
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: William F. McKay, Scott D. Boden, Neil B. Beals
  • Publication number: 20110077382
    Abstract: A collagen peptide with immune-enhancing activity from Cyanea nozakii, and a preparation method thereof are provided. The collagen peptide contains 80-90 wt % of proteins and 10-20 wt % of sugars, and has an average molecular weight of 1,000-3,000. Monosackcharides contained in the collagen peptide are mainly glucose, glycine accounts for 16% or above and the sum of praline and hydroxyproline accounts for 18% or above of amino acids contained therein. The collagen peptide is capable of being used for preparation of medicines, health products, and skincare cosmetics having immune-enhancing function.
    Type: Application
    Filed: September 17, 2008
    Publication date: March 31, 2011
    Applicants: JIANGNAN UNIVERSITY
    Inventors: Luhong Tang, Bentian Zhang, Chao Deng, Dan Lin, QI Wang, Wei Chen
  • Patent number: 7722895
    Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: May 25, 2010
    Inventors: William F. McKay, Scott D. Boden, Neil Beals
  • Patent number: 7671041
    Abstract: This invention relates to a hydrolysate of avian cartilage comprising 45% to 70% by weight of hydrolysed type II collagen, 9% to 15% by weight of chondroitin sulphate, 0.5% to 2% in weight of hyaluronic acid; with a composition of amino acids in which valine represents 2.7% to 3.3%, isoleucine represents 2.0 to 2.4, phenylalanine represents 2.2% to 2.6%, lysine represents 3.8% to 4.2%, tryptophane represents 0.4% to 0,6%, hydroxyproline represents 5.5% to 8.7%, hydroxylysine represents 0.7% to 1.8%, and in which the molar ratio between hydroxyproline and hydroxylysine is between 5.0 and 8.0; and having an average molecular weight of the peptidic fraction between 500 and 1000 Daltons. The invention also relates to a process for preparing said hydrolysate, and its use as a food complement, and/or as a medicament, particularly for treatment or prevention of joint pain.
    Type: Grant
    Filed: June 19, 2006
    Date of Patent: March 2, 2010
    Assignee: Diana Naturals
    Inventors: Eric Vouland, Cä{umlaut over (c)}ü{umlaut over ( )}ëline Berger
  • Publication number: 20090312524
    Abstract: In various embodiments, a collagen product is provided that is derived from an animal, the collagen product comprises precipitated collagen that is substantially pure. In various embodiments, the collagen is obtained from a marine animal and does not contain prions or viruses. In various embodiments, the collagen can be made or incorporated into collagen films, collagen membranes, cosmetic collagen masks, collagen sponges, gelatin, hemostasis sponges, lyophilized foams, collagen injections, artificial skins and dura, bones, cartilage, screws, shafts, stems, or tube guides.
    Type: Application
    Filed: November 29, 2004
    Publication date: December 17, 2009
    Applicant: ALTERNATIVE SOURCED COLLAGEN, LLC
    Inventor: Nels J. Lauritzen
  • Publication number: 20090264921
    Abstract: Disclosed is an adhesive hemostatic agent based on non-blood constituents including DOPA, able to strongly adhere to collagen fibers. The agent includes an antifibrinolytic agent in addition to an esterified atelocollagen which is non-immunogenic and may become positively charged thereon such that the adhesive hemostatic agent has no possibility of mediating particular diseases or viral infections (HIV, HCV, HBV, CMV, etc), unlike conventional agents comprising blood constituents, and readily binds to negatively charged platelets at high adhesive strength, thus inducing quick blood coagulation. Also, provided is a method for preparing the same.
    Type: Application
    Filed: April 15, 2009
    Publication date: October 22, 2009
    Applicants: DALIM BIOTECH Co., Ltd., Industry-Academic Cooperation Foundation Yongsei-University
    Inventor: Hwal SUH
  • Publication number: 20080260794
    Abstract: Medical implants and methods for forming a medical implant blends a dispersion of human collagen fibers and/or threads and optionally a volume between about 2 to about 15% of an alcohol and forms medical implants by removing a liquid component of the collagen dispersion. Medical implants formed include collagen films, coatings, threads, patches, tubes, plugs, scaffolds, injectable collagen, and collagen for in vitro applications.
    Type: Application
    Filed: February 12, 2008
    Publication date: October 23, 2008
    Inventors: Nels J. Lauritzen, Lawrence A. Shimp, Brent Mitchell
  • Patent number: 7091180
    Abstract: Hydrolyzed collagen type II powder compositions for inducing cartilage formation in an individual, method of preparing the compositions and use of the compositions in treating connective tissue disorder, replenishing skin viscoelasticity. The compositions are administered through an orally ingestible delivery medium for absorption into the gastrointestinal tract. The compositions are administered through a topical delivery medium for absorption into a dermis of the individual.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: August 15, 2006
    Assignee: Intellipi, LLC
    Inventor: Suhail Ishaq
  • Patent number: 6780841
    Abstract: Hydrolyzed collagen type II powder compositions for inducing cartilage formation in an individual, method of preparing the compositions and use of the compositions in treating connective tissue disorder, replenishing skin viscoelasticity. The compositions are administered through an orally ingestible delivery medium for absorption into the gastrointestinal tract. The compositions are administered through a topical delivery medium for absorption into a dermis of the individual.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: August 24, 2004
    Assignee: BioCell Technology, LLC
    Inventor: Suhail Ishaq
  • Patent number: 6679918
    Abstract: The present invention provides compositions for an implantable putty material for delivery of active compounds to a patient. More specifically, the present invention provides a material having a pH of between about 3 and 6 and possessing putty-like physical properties, wherein the composition of the material includes collagen and water. The present invention also provides a method for using the implantable putty material.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: January 20, 2004
    Assignee: Centerpulse Biologics Inc.
    Inventors: James J. Benedict, Christopher J. Damien
  • Patent number: 6346515
    Abstract: A collagen matrix comprises collagen fibrils which are cross-linked to one another by reducing sugar or a reducing sugar derivative. The collagen matrix may be formed into a membrane useful in guided tissue regeneration.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: February 12, 2002
    Assignee: Colbar R & D Ltd.
    Inventors: Sanhu Pitaru, Matityahu Noff
  • Patent number: 6323319
    Abstract: Hydrolyzed collagen type II powder compositions, method of preparing the compositions and use of the compositions in treating cartilage defects. The compositions are orally administered to an individual in need of cartilage augmentation in a daily dosage of between about 2,000 and 3,000 mg per day.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: November 27, 2001
    Assignee: Five Continent Enterprise, Inc.
    Inventor: Ahmed Alkayali
  • Patent number: 6183741
    Abstract: The present invention is a process for reducing gelatin insolubles which includes providing a gelatin solution and adding to the gelatin solution amylase in an amount to provide a concentration of amylase of at least 0.1 ppm for a time sufficient to reduce gelatin insolubles. The present invention also provides a gelatin having a Bloom strength of from 60 to 400 and a concentration of amylase of greater than 0.1 ppm.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: February 6, 2001
    Assignee: Eastman Kodak Company
    Inventors: Anne G. Rowlands, Robert F. Rainville
  • Patent number: 6184011
    Abstract: A method of releasing particulates from a solid matrix is provided. The method is effected adding to the solid matrix a degrading enzyme capable of degrading the solid matrix, to thereby release the particulates from the solid matrix.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: February 6, 2001
    Assignees: CBD Technologies, LTD, Yissum R&D Company of the Hebrew University
    Inventors: Daniel L. Siegel, Oded Shoseyov
  • Patent number: 6100381
    Abstract: The present invention is a process for the manufacture of gelatin which includes providing a collagen containing material and demineralizing the collagen containing material to produce ossein. An enzyme solution containing protease at a concentration of at least 10 ppb is added to the ossein for a time sufficient to solubilize the ossein to produce a solution containing the gelatin at a weight percent of from 0.5 to 6 and at a predetermined viscosity.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: August 8, 2000
    Assignee: Eastman Kodak Company
    Inventors: Anne G. Rowlands, Deborah J. Burrows
  • Patent number: 6096346
    Abstract: A method of obtaining an extract of shark's cartilage is provided wherein a shark's cartilage is processed through five steps. The five steps are smashing, cleaning, purifying, deodorizing, and sterilizing. The result of this process is a pure white product with no fishy smell.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: August 1, 2000
    Inventor: Chun-Yuan Chen
  • Patent number: 6080843
    Abstract: The present invention is a gelatin composed of a high molecular weight fraction (>250,000) of from 0 to 25 wt %, a beta fraction (150,000-250,000) of from 0 to 20 wt % and an alpha fraction (50,000-150,000) of from 15 to 55 wt %. The gelatin has a Gel strength of from 150 to 350 g Bloom and a concentration of protease of greater than 10 ppb and an absorbance of at least 0.069 at 420 nm. The present invention also is a process for the manufacture of photographic gelatin. The process begins by liquefying or slurrying the residual ossein. Protease is added to the gelatin solution or ossein slurry to a concentration of at least 10 ppb to form a mixture. The mixture is reacted for a time sufficient to achieve a viscosity of less than 9 cps (6.16% gel concentration at 104.degree. F.) and the protease is inactivated. The mixture is clarified to form a gelatin solution wherein the gelatin is of high quality.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: June 27, 2000
    Assignee: Eastman Kodak Company
    Inventors: Robert F. Rainville, Anne G. Rowlands, Deborah J. Burrows, Peter Noble
  • Patent number: 6043078
    Abstract: The present invention is a process for reducing biological growth in aqueous solutions. An aqueous solution is provided. An amylase solution is added to the aqueous solution to provide an amylase concentration of greater than 1 unit/ml enzyme activity thereby reducing biological growth in the aqueous solution.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: March 28, 2000
    Assignee: Eastman Kodak Company
    Inventors: Anne G. Rowlands, Mark S. Fornalik
  • Patent number: 6040155
    Abstract: The present invention provides nucleic acid and corresponding amino acid sequences of a multifunctional protein that has been found to be useful in numerous medical and cosmetic contexts. A protein having "multifunctional activity," is defined herein as including at least one of a chymotrypsin, trypsin, collagenase, elastase or exo peptidase activity or asialo GM.sub.1 ceramide binding activity. These proteins are useful for multiple purposes, including treating viral infections such as herpes outbreaks, fungal, bacterial or parasitic infections, including the primary and secondary infections of leprosy, colitis, ulcers, hemorrhoids, corneal scarring, dental plaque, acne, cystic fibrosis, blood clots, wounds, immune disorders including autoimmune disease and cancer.
    Type: Grant
    Filed: August 28, 1996
    Date of Patent: March 21, 2000
    Inventors: John Kay, Peter Kille
  • Patent number: 6037451
    Abstract: The present invention is a process for degreasing bone for the manufacture of gelatin. A lipase solution at a concentration of greater than 0.1 ppm is added to a collagen containing material and treated for a time sufficient to solubilize the fat contained in the collagen containing material to produce degreased collagen containing material with a fat content of less than 1 weight percent.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: March 14, 2000
    Assignee: Eastman Kodak Company
    Inventor: Anne G. Rowlands
  • Patent number: 6025327
    Abstract: Hydrolyzed collagen type II powder compositions, method of preparing the compositions and use of the compositions in treating cartilage defects. The compositions are orally administered to an individual in need of cartilage augmentation in a daily dosage of between about 2,000 and 3,000 mg per day.
    Type: Grant
    Filed: August 8, 1997
    Date of Patent: February 15, 2000
    Assignee: Biocell Technology, LLC
    Inventor: Ahmed Alkayali
  • Patent number: 6020474
    Abstract: The present invention provides two ATP synthase subunits (designated individually as Asy-1 and Asy-2, and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Asy and a method for producing Asy. The invention also provides for use of Asy and agonists, antibodies, or antagonists specifically binding Asy, in the prevention and treatment of diseases associated with expression of Asy. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Asy for the treatment of diseases associated with the expression of Asy. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Asy.
    Type: Grant
    Filed: January 15, 1997
    Date of Patent: February 1, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Jennifer L. Hillman, Surya K. Goli
  • Patent number: 5973130
    Abstract: The present invention provides a human Ras-like protein (RLP) and polynucleotides which identify and encode RLP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing RLP and for treating or preventing disorders associated with expression of RLP.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: October 26, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Surya K. Goli, Neil C. Corley
  • Patent number: 5955438
    Abstract: A collagen matrix comprise collagen fibrils which are cross-linked to one another by a reducing sugar or a reducing sugar derivative. The collagen matrix may be formed into a membrane useful in guided tissue regeneration.
    Type: Grant
    Filed: July 19, 1995
    Date of Patent: September 21, 1999
    Assignee: ColBar R & D Ltd.
    Inventors: Sandu Pitaru, Matityahu Noff
  • Patent number: 5861495
    Abstract: The present invention provides three zinc binding proteins (designated individually as ZB-1, ZB-2, and ZB-3, and collectively as ZB) and polynucleotides which identify and encode ZB. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding ZB and a method for producing ZB. The invention also provides for use of ZB and agonists, antibodies, or antagonists specifically binding ZB, in the prevention and treatment of diseases associated with expression of ZB. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding ZB for the treatment of diseases associated with the expression of ZB. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding ZB.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: January 19, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Janice Au-Young, Roger Coleman, Surya K. Goli
  • Patent number: 5847093
    Abstract: The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding APRG and a method for producing APRG. The invention also provides for agonists, antibodies, or antagonists specifically binding APRG, and their use, in the prevention and treatment of diseases associated with expression of APRG. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding APRG for the treatment of diseases associated with the expression of APRG. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding APRG.
    Type: Grant
    Filed: December 27, 1996
    Date of Patent: December 8, 1998
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Surya K. Goli, Jennifer L. Hillman
  • Patent number: 5831049
    Abstract: The present invention provides a human thioredoxin (TRDX) and polynucleotides which identify and encode TRDX. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TRDX and a method for producing TRDX. The invention also provides for agonists, antibodies, or antagonists specifically binding TRDX, and their use, in the prevention and treatment of diseases associated with expression of TRDX. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TRDX for the treatment of diseases associated with the expression of TRDX. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TRDX in the production of recombinant proteins. The invention also provides for the use of purified TRDX in the production of recombinant proteins.
    Type: Grant
    Filed: January 3, 1997
    Date of Patent: November 3, 1998
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Surya K. Goli
  • Patent number: 5830660
    Abstract: The present invention provides a human tumorigenesis protein (HTAP) and polynucleotides which identify and encode HTAP. In addition, the invention provides expression vectors and host cells, agonists, antibodies, and antagonists. The invention also provides methods for producing HTAP and for treating or preventing disorders associated with the expression of HTAP.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: November 3, 1998
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Surya K. Goli
  • Patent number: 5831052
    Abstract: The present invention provides a human translocation associated protein (Gp25L-H) and polynucleotides which identify and encode Gp25L-H. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of Gp25L-H, as well as diagnostic assays.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: November 3, 1998
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Neil C. Corley, Surya K. Goli
  • Patent number: 5810970
    Abstract: A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; forming the interacted cellulosic pulp slurry and solubilized collagen into a sheet; and drying the sheet; also, a method for using solubilized collagen for strengthening paper by mixing the solubilized collagen with a cellulosic pulp slurry; and making a cellulosic pulp product from the mixture and drying.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 22, 1998
    Assignee: Ranpak Corporation
    Inventors: Kenneth E. Hughes, David C. Masterson, David J. Fink, Barbara A. Metz, Gordon E. Pickett, Paul M. Gemmer
  • Patent number: 5744002
    Abstract: A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; forming the interacted cellulosic pulp slurry and solubilized collagen into a sheet; and drying the sheet; also, a method for using solubilized collagen for strengthening paper by mixing the solubilized collagen with a cellulosic pulp slurry; and making a cellulosic pulp product from the mixture and drying.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 28, 1998
    Assignee: Ranpak Corp.
    Inventors: Kenneth E. Hughes, David C. Masterson, David J. Fink, Barbara A. Metz, Gordon E. Pickett, Paul M. Gemmer, Richard S. Brody
  • Patent number: 5736010
    Abstract: A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; forming the interacted cellulosic pulp slurry and solubilized collagen into a sheet; and drying the sheet; also, a method for using solubilized collagen for strengthening paper by mixing the solubilized collagen with a cellulosic pulp slurry; and making a cellulosic pulp product from the mixture and drying.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 7, 1998
    Assignee: Ranpak Corporation
    Inventors: Kenneth E. Hughes, David C. Masterson, David J. Fink, Barbara A. Metz, Gordon E. Pickett, Paul M. Gemmer, Richard S. Brody
  • Patent number: 5714042
    Abstract: A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; forming the interacted cellulosic pulp slurry and solubilized collagen into a sheet; and drying the sheet; also, a method for using solubilized collagen for strengthening paper by mixing the solubilized collagen with a cellulosic pulp slurry; and making a cellulosic pulp product from the mixture and drying.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 3, 1998
    Assignee: Ranpak Corporation
    Inventors: Kenneth E. Hughes, David C. Masterson, David J. Fink, Barbara A. Metz, Gordon E. Pickett, Paul M. Gemmer, Richard S. Brody