With Sample Or Reagent Mechanical Transport Means Patents (Class 435/287.3)
  • Patent number: 10371709
    Abstract: A modular automatic analyzer using a circular type cartridge enabling centrifugation according to an exemplary embodiment of the present invention includes: a main body frame; an X-axis conveying unit which reciprocally moves in an X-axis direction with respect to the main body frame; a circular type cartridge accommodating housing which is installed with respect to the X-axis conveying unit so as to be reciprocally movable in the X-axis direction by the X-axis conveying unit, a single rotation drive unit which is installed in the circular type cartridge accommodating housing and is rotated step by step at a predetermined interval or rotated at a high speed for centrifugation, a circular type cartridge which is installed at an upper surface of the circular type cartridge accommodating housing so as to be rotatably connected to the rotation drive unit and has wells disposed to be spaced apart from each other at predetermined intervals in a circumferential direction of a disc-shaped main body, a tip lifting uni
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: August 6, 2019
    Assignee: I-SENS, INC.
    Inventors: Kyungho Kim, Jae Phil Do, Jaewon Jung, Jung Uk Ha, Sang Taek Shin, Seok-Won Lee, Yungjoon Jin, Yusung Kim
  • Patent number: 10234451
    Abstract: The disclosure relates to a method and device for detecting and quantifying biological molecules such as cell surface or intracellular ligands/receptors in a dynamic system with high sensitivity and specificity; the method of using such platform optionally in combination with an optical detection system and kits comprising the optical platform.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: March 19, 2019
    Assignee: National University of Singapore
    Inventors: Ramesh Ramji, Fook Chiong Cheong, Chwee Teck Lim
  • Patent number: 10092233
    Abstract: Disclosed are a non-invasive liver function testing apparatus and method. The non-invasive liver function testing apparatus includes a light source configured to irradiate light onto an object, a light detector configured to detect information about light reflected from the object, a raw data extractor configured to extract raw data, associated with at least one target material constituting the object, from the information detected by the light detector, and a data processor configured to extract liver function-related information, including a correlation with the at least one target material, from the raw data.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: October 9, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Joonhyung Lee, Sangkyu Kim
  • Patent number: 9732314
    Abstract: An apparatus for culturing cells of the present disclosure includes: a cabinet that has a main surface and a side surface, the main surface having a window; a main surface aspiration port disposed at the main surface of the cabinet; and a side surface aspiration port disposed at the side surface of the cabinet. In the cross section of the cabinet taken along the horizontal direction, a first vessel supplying part for supplying a first vessel is disposed at a midportion of the cabinet, and a second vessel supplying part for supplying a second vessel is disposed at an inner peripheral portion of the cabinet. The first vessel supplying part has a first lid capable of entirely covering the first vessel supplying part. The first vessel has no lid. The second vessel supplying part has no lid. The second vessel has a second lid.
    Type: Grant
    Filed: March 19, 2016
    Date of Patent: August 15, 2017
    Assignee: Panasonic Corporation
    Inventors: Norihiro Shibata, Toshiaki Yamauchi, Takeshi Ando
  • Patent number: 9702871
    Abstract: Examples are described including measurement systems for conducting competition assays. A first chamber of an assay device may be loaded with a sample containing a target antigen. The target antigen in the sample may be allowed to bind to antibody-coated beads in the first chamber. A control layer separating the first chamber from a second chamber may then be opened to allow a labeling agent loaded in a first portion of the second chamber to bind to any unoccupied sites on the antibodies. A centrifugal force may then be applied to transport the beads through a density media to a detection region for measurement by a detection unit.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: July 11, 2017
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Chung-Yan Koh, Matthew E. Piccini, Anup K. Singh
  • Patent number: 9649582
    Abstract: An apparatus for collecting solid materials from a fluid is provided. The apparatus includes a conduit configured to allow the fluid to flow therethrough. The apparatus further includes a mesh extending across the conduit. The mesh is configured to allow the fluid to flow therethrough and to allow a solid material to precipitate out of the fluid onto the mesh. The apparatus further includes a support structure configured to support the mesh in position across the conduit.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: May 16, 2017
    Inventor: James H. Shnell
  • Patent number: 9475024
    Abstract: A plurality of individual single column test elements are provided for use in a clinical testing apparatus in an open-topped cartridge in which each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover strip used to access the contents of the test column. The number of individual test elements provided in a cartridge can be varied, depending on the test(s) to be performed.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: October 25, 2016
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Raymond F. Jakubowicz, Mark Sawczuk
  • Patent number: 9120067
    Abstract: There are provided a micro mixer capable of efficiently mixing at least two types of liquids in a simple structure and a microfluidic chip provided with the micro mixer. In order to achieve the object, the micro mixer includes a minute passage through which first and second liquids are caused to flow respectively, and a mixing vessel in which a liquid injecting port caused to communicate with the minute passage is provided in a bottom part, and the liquid injecting port is provided in a shifted position from a center of the bottom part in the bottom part. Moreover, the liquid injecting port may be provided in a shifted position from a center line of the mixing vessel.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: September 1, 2015
    Assignee: KONICA MINOLTA, INC.
    Inventors: Kenichi Miyata, Takahiro Mohri, Kusunoki Higashino, Yasuhiro Sando, Masashi Nishikado, Gou Yanagihara
  • Patent number: 9108832
    Abstract: A cover opener for opening a cover 1a that is rotationally removed from and fixed to a reagent container 1 includes: a rotational drive unit 12 and a cover retainer 17 to retain the cover 1a by becoming engaged with a concave portion 1b provided on an upper portion of the cover 1a. A carrier 16 is driven to rotate as the rotational drive unit rotates, as well as to move in a direction of a rotational axis with respect to the rotational drive unit. Springs 19 and 20, one of which is provided between the rotational drive unit and the cover retainer, and the other between the rotational drive unit and the carrier, bias the rotational drive unit and the cover retainer or the carrier in relative fashion to move away from each other. This enables the cover of the reagent container to be reliably opened.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: August 18, 2015
    Assignee: HITACHI HIGH TECHNOLOGIES CORPORATION
    Inventors: Masanori Akutsu, Takeshi Shibuya
  • Patent number: 9052297
    Abstract: A plurality of individual single column test elements are provided for use in a clinical testing apparatus. Each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover strip used to access the contents of the test column. Individual test elements can be stored, retained and dispensed for testing patient samples.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: June 9, 2015
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Raymond F. Jakubowicz, Mark Sawczuk
  • Patent number: 9046455
    Abstract: Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: June 2, 2015
    Assignee: Beckman Coulter, Inc.
    Inventors: Brian D. Wilson, David L. Anderson, Matthew S. Davis, Matthew D. Erickson, Alan N. Johnson, Garrick A. Maurer, Michael J. Rosen, Mark F. Sauerburger, Daniel R. Schmidt, Joshua D. Wiltsie
  • Patent number: 9040288
    Abstract: This patent application describes an integrated apparatus for processing polynucleotide-containing samples, and for providing a diagnostic result thereon. The apparatus is configured to receive a microfluidic cartridge that contains reagents and a network for processing a sample. Also described are methods of using the apparatus.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: May 26, 2015
    Assignee: HandyLab, Inc.
    Inventors: Kalyan Handique, Sundaresh N. Brahmasandra, Karthik Ganesan, Betty Wu, Nikhil Phadke, Gene Parunak, Jeff Williams
  • Patent number: 9023640
    Abstract: A portable system for real time detection of the presence of an infectious agent in a biological sample employs a reagent which detects the presence of a specific infectious agent in the sample, and emits a detectable signal when the reagent reacts with the sample and detects the presence of the infectious agent. A test cartridge has a reaction chamber for receiving the sample and the reagent. The reaction chamber has a predetermined internal geometry and at least one inner surface. Introducing the sample and the reagent into the test cartridge mixes the sample and the reagent. A testing unit receives the test cartridge, and includes a sensor for detecting an emitted detectable signal. The detection of the emitted detectable signal is indicative of the presence of the infectious agent in the sample.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: May 5, 2015
    Assignee: Fundamental Solutions Corporation
    Inventors: Marvin R. Williams, Charles McBrairty, Daniel W. Pfautz, Thomas J. Zupancic, Lingchun Zeng, Andrew Weiman, Richard S. Brody, Joseph Kittle, Anthony Truscott, Robert Baranowski
  • Publication number: 20150118688
    Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 30, 2015
    Inventors: Kristin Weidemaier, Robert L. Campbell, Erin Gooch Carruthers, Adam C. Curry, Kevin G. Dolan, Andrea Liebmann-Vinson, Wendy Dale Woodley, Melody M.H. Kuroda, Ammon David Lentz, Dwight Livingston, Michael Justin Lizzi, Artis R. Lockhart, Ernie Ritchey, Eric A. Fallows, Donald E. Gorelick, Jack Kessler, Spencer Lovette, Jeffrey S. Ojala, Mark A. Talmer, Miroslaw Bartkowiak, Scott N. Danhof, Gregory S. Kramer, Thomas D. Haubert, Michael L. Marshall, James A. Prescott, Randy J. Somerville, M. Scott Ulrich, David S. Sebba
  • Patent number: 9012208
    Abstract: A self-contained apparatus for isolating nucleic acid, cell lysates and cell suspensions from unprocessed samples apparatus, to be used with an instrument, includes at least one input, and: (i) a macrofluidic component, including a chamber for receiving an unprocessed sample from a collection device and at least one filled liquid purification reagent storage reservoir; and (ii) a microfluidic component in communication with the macrofluidic component through at least one microfluidic element, the microfluidic component further comprising at least one nucleic acid purification matrix; and (iii) at least one interface port to a drive mechanism on the instrument for driving said liquid purification reagent, through the microfluidic element and the nucleic acid purification matrix, wherein the only inputs to the apparatus are through the chamber and the interface port to the drive mechanism.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: April 21, 2015
    Assignee: NetBio, Inc.
    Inventors: Richard F. Selden, Eugene Tan
  • Patent number: 8999665
    Abstract: A molecule trapping method includes forming a fluid bridge between a first reservoir and a second reservoir, translocating a molecule from the first reservoir to the second reservoir through the fluid bridge, detecting when a segment of the molecule is in the fluid bridge, breaking the fluid bridge and forming an a gap between the first and the second reservoirs, thereby trapping a segment of the molecule in the gap and making measurements on the segment of the molecule.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: April 7, 2015
    Assignee: International Business Machines Corporation
    Inventors: Venkat S. K. Balagurusamy, Stanislav Polonsky
  • Patent number: 8999046
    Abstract: A cell expansion system includes an air removal chamber to provide a bubble trap so that air and/or gas bubbles do not enter the bioreactor of the cell expansion system. The air removal chamber includes a pair of ports situated at the bottom of the air removal chamber. An entrance port allows fluid to enter the air removal chamber, and an exit port allows fluid to exit the air removal chamber. In one embodiment the air removal chamber forms an element of a premounted fluid conveyance assembly for use with a cell expansion machine.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: April 7, 2015
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas G. DiLorenzo, Edward Allan Stanton
  • Patent number: 8996163
    Abstract: Disc dispensing device for dispensing discs impregnated with antibiotics onto a culture dish. The device comprises a stationary support on which a magazine is removably mounted. The magazine holds a plurality of tubular containers each containing a stack of discs to be dispensed. A moving means moves one disc from a bottom end of a tubular container to a pick-up position. From the pick-up position a transfer means picks up said one disc and transfers it to the culture dish where it is dispensed. The removable culture dish is supported by a moveable carriage which is mounted on the stationary support. The carriage is moveable relative to the magazine from a starting position to an operating position and vice versa. Control means control the operation of the device. The plurality of tubular containers is rotatable around a magazine center under control of the control means.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: March 31, 2015
    Assignee: BD Kiestra B.V.
    Inventors: Jetze Botma, Martijn Kleefstra, Trienko Marten van der Kaap, Martijn Xander Berntsen, Jan Bart van der Vijver
  • Patent number: 8993237
    Abstract: A thermal cycling device for performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray. The thermal cycling device includes a sample block assembly, an optical detection system, and a sample well tray holder configured to hold the sample well tray. The sample block assembly is adapted for translation between a first position permitting the movement of the sample well tray into alignment with sample block assembly, and a second position, upward relative to the first position, where the sample block assembly contacts the sample well tray. A method of performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray in a thermal cycling device is also provided.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: March 31, 2015
    Assignee: Applied Biosystems, LLC
    Inventor: Donald R. Sandell
  • Patent number: 8993241
    Abstract: Provided is a device and a method whereby plural kinds of reaction operations and washing operations can be conducted in parallel without washing or replacing an instrument used in transferring a solution in each operation. A reaction device having a plurality of projecting barriers provided in a line on one surface of a substrate. The projecting barrier has a cutoff portion and an inner space capable of holding a droplet and having a contact angle to pure water of from 90 to 150 degrees. A reaction method using the reaction device wherein a substance immobilized on magnetic beads is sequentially transferred in and between droplets of a solution containing a surface tension reducing agent that are held in the spaces for holding a droplet by means of a magnet located on the opposite surface of the substrate to thereby conduct reactions and washings.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: March 31, 2015
    Assignee: National University Corporation University of Toyama
    Inventors: Masaharu Isobe, Nobuyuki Kurosawa
  • Patent number: 8986982
    Abstract: A thermal cycle system and method suitable for mass production of DNA comprising a temperature control body having at least two sectors. Each sector has at least one heater, cooler, or other means for changing temperature. A path traverses the sectors in a cyclical fashion. In use, a piece of tubing or other means for conveying is placed along the path and a reaction mixture is pumped or otherwise moved along the path such that the reaction mixture is repetitively heated or cooled to varying temperatures as the reaction mixture cyclically traverses the sectors. The reaction mixture thereby reacts to form a product. In particular, polymerase chain reaction reactants may continuously be pumped through the tubing to amplify DNA. The temperature control body is preferably a single aluminum cylinder with a grooved channel circling around its exterior surface, and preferably has wedge-shaped or pie-shaped sectors separated by a thermal barrier.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: March 24, 2015
    Assignee: Marshall University Research Corporation
    Inventors: Derek A. Gregg, Elizabeth E. Murray, Michael L. Norton, Justin T. Swick, Herbert Tesser
  • Patent number: 8986988
    Abstract: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: March 24, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Rohit Nandkumar Karnik, Seungpyo Hong, Ying Mei, Daniel Griffith Anderson, Jeffrey Michael Karp, Robert S. Langer, Suman Bose
  • Patent number: 8969071
    Abstract: An apparatus for passive sorting of microdroplets including a main flow channel, a flow stream of microdroplets in the main flow channel wherein the microdroplets have substantially the same diameter and wherein the flow stream of microdroplets includes first microdroplets having a first degree of stiffness and second microdroplets having a second degree of stiffness wherein the second degree of stiffness is different than the first degree of stiffness. A second flow channel is connected to the main flow channel for the second microdroplets having a second degree of stiffness. A separator separates the second microdroplets having a second degree of stiffness from the first microdroplets and directs the second microdroplets having a second degree of stiffness into the second flow channel.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: March 3, 2015
    Assignees: Lawrence Livermore National Security, LLC, The Regents of the University of California
    Inventors: Neil Reginald Beer, Abraham P. Lee, Andrew C. Hatch, Jeffrey S. Fisher
  • Patent number: 8969072
    Abstract: The present invention is directed to a method and automated unloading means for unloading a container from an apparatus. The apparatus of the present invention may include a means for automated loading, a means for automated transfer and/or a means for automated unloading of a container (e.g., a specimen container). In one embodiment, the apparatus can be an automated detection apparatus for rapid non-invasive detection of a microbial agent in a test sample. The detection system also including a heated enclosure, a holding means or rack, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.
    Type: Grant
    Filed: May 14, 2010
    Date of Patent: March 3, 2015
    Assignee: bioMerieux, Inc.
    Inventors: Ronnie J. Robinson, Mark Joseph Fanning, Stanley Michael Philipak, Anthony Valentino, Mike Ammerman
  • Patent number: 8969073
    Abstract: The invention describes an appliance and a method, with the help of which specific bio-particles, but also dissolved bio-molecules can be recognized in and separated from fluids making use of suitable carriers and known immobilization methods. The appliance can be used both discontinuously and also for direct and continuous treatment of fluids. Fields of application of the invention are animals, bio-technology (including biological research) and medicinal diagnostics. Areas of application of the invention comprise, among others, therapy of humans, in particular direct treatment of blood.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: March 3, 2015
    Assignee: pluriSelect GmbH
    Inventor: Hans Werner Heinrich
  • Publication number: 20150056689
    Abstract: A sample preparation and analysis system. The system includes a housing with a sample preparation station and a sample analysis station positioned within the housing. The sample analysis station is spaced away from the sample preparation station. A transport assembly is configured to move at least one sample within the housing and between the sample preparation station and the sample analysis station.
    Type: Application
    Filed: July 17, 2014
    Publication date: February 26, 2015
    Inventors: Robert DeWitte, Juhani Siidorov, Vesa Nuotio, Jukka Saukkonen, John Edward Brann, III, Terry N. Olney
  • Patent number: 8962308
    Abstract: Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: February 24, 2015
    Assignee: Beckman Coulter, Inc.
    Inventors: Brian D. Wilson, Sami D. Alaruri, Matthew S. Davis, Matthew D. Erickson, Alan N. Johnson, Garrick A. Maurer, Mark F. Sauerburger, Daniel R. Schmidt, Joshua D. Wiltsie, Thomas M. Stachelek, David L. Yang
  • Patent number: 8962258
    Abstract: Provided are a multiple immunoassay apparatus on a chip in which a structure comprising multiple microfluidic channels is associated with a tissue sample, which allows immunohistochemical reactions to be conducted therein, to examine various markers specific for certain diseases, and a method for performing multiple immunoassays using the same. The multiple immunoassay apparatus comprises: at least one antibody-introducing unit through which at least one antibody is introduced into the apparatus; at least one reaction unit in which the antibody reacts with a sample in an immunohistochemical pattern; and at least one fluid outlet through which a fluid including the antibody is discharged outside the apparatus.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: February 24, 2015
    Assignees: Korea Advanced Institute of Science and Technology, National Cancer Center
    Inventors: Je-Kyun Park, MinSeok Kim, Eun Sook Lee, Sun-Young Kong, Solm Kwon
  • Patent number: 8961904
    Abstract: A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: February 24, 2015
    Assignee: Premium Genetics (UK) Ltd.
    Inventors: Zheng Xia, Yu Zhou, John Larsen, Guocheng Shao, Shane Peterson, Marjorie Faust
  • Patent number: 8945481
    Abstract: Exemplary embodiments provide microfludic devices and methods for their use. The microfluidic device can include an array of M×N reaction sites formed by intersecting a first and second plurality of fluid channels of a flow layer. The flow layer can have a matrix design and/or a blind channel design to analyze a large number of samples under a limited number of conditions. The microfluidic device can also include a control layer including a valve system for regulating solution flow through fluid channels. In addition, by aligning the control layer with the fluid channels, the detection of the microfluidic devices, e.g., optical signal collection, can be improved by piping lights to/from the reaction sites. In an exemplary embodiment, guard channels can be included in the microfluidic device for thermal cycling and/or reducing evaporation from the reaction sites.
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: February 3, 2015
    Assignee: Applied Biosystems, LLC
    Inventors: Mark F. Oldham, Kenneth J. Livak, Jason E. Babcoke, H. Pin Kao, Stephen J. Gunstream, Kevin S. Bodner, Douglas P. Greiner, Nigel P. Beard, Dar Bahatt
  • Patent number: 8945480
    Abstract: The invention provides an apparatus and methodology to carry out biochemical testing on a centrifugal platform using flow splitting technique. In conventional biochemical testing, reagents need to be loaded individually into each reservoir. By using the flow splitting technique in this invention, one reagent only need to be loaded once, then, it can be evenly distributed into each reaction chambers in single or multiple layers format. The invention greatly reduces the required manpower when large numbers of assays are integrated on one platform. Because of the invention, many medical examinations can be performed efficiently, thus reduce the waste of manpower, time and cost.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: February 3, 2015
    Assignee: Feng Chia University
    Inventors: Chih-Hsin Shih, Ho-Chin Wu, Yu-Ping Yang
  • Patent number: 8945470
    Abstract: The present invention is to present a sample analyzer comprising: a first measurement unit; a second measurement unit; a transport unit for transporting a sample container to the first measurement unit and the second measurement unit; and a controller configured to perform operations comprising: obtaining measurement item information indicating a measurement item of the sample contained in the sample container; and controlling the transport unit so as to transport the sample container to the second measurement unit when a first measurement item and a second measurement item different from the first measurement item are indicated in the measurement item information, and controlling the transport unit so as to transport the sample container to the first measurement unit or the second measurement unit when the first measurement item is indicated and the second measurement item is not indicated in the measurement item information.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: February 3, 2015
    Assignee: Sysmex Corporation
    Inventors: Keisuke Kuwano, Daigo Fukuma
  • Publication number: 20150031074
    Abstract: A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.
    Type: Application
    Filed: August 7, 2014
    Publication date: January 29, 2015
    Inventors: Ronnie J. Robinson, Mark S. Wilson, Christopher S. Ronsick, John D. Walsh, Jones M. Hyman, Thurman C. Thorpe, Bradford G. Clay
  • Publication number: 20150017713
    Abstract: A micro fluid dosing unit includes a test container containing biomaterial needing oxygen. The test container has at least one first container which contains water and at least one second container which contains a pharmacological substance, wherein the first and the second containers have a container outlet leading to the test container and are mounted on a common valve carrier plate containing control channels, which includes control channel ports for control valves to be coupled thereto. In the valve carrier plate a separate valve control chamber is formed for each container, which is sealed by a membrane, wherein associated container outlets are opened and closed by the membrane movement.
    Type: Application
    Filed: July 8, 2014
    Publication date: January 15, 2015
    Inventor: Peggy SCHAEFER
  • Publication number: 20150010993
    Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
    Type: Application
    Filed: July 14, 2014
    Publication date: January 8, 2015
    Inventors: Gal Ingber, William G. Atterbury, Russell H. Barnes, Douglas E. Boyd, Joseph D. Dennis, Jonathan Gurfinkel, Dave Holley, Steven E. Huckaby, Thomas A. Klausing, Kevin Sadeski, Jason A. Schaefer, K. Bryan Scott, Carol Stillman, Sherwood Talbert, John Tallarico, John S. Laudo
  • Publication number: 20150011404
    Abstract: Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries.
    Type: Application
    Filed: September 9, 2014
    Publication date: January 8, 2015
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Manu Prakash, Neil Gershenfeld
  • Patent number: 8927272
    Abstract: A method for removing material from a vesicular object by securing the object, penetrating the object with a pipette, such pipette having a sealed distal tip and an aperture, advancing said pipette into the object in such a manner as to place the aperture directly adjacent to the material to be removed from the object, applying vacuum inside the pipette thereby drawing the material to be removed from the object into the pipette, and removing the pipette from the object in such a manner as to cut or otherwise separate the material in the pipette from the object thereby leaving the material removed from the object in the pipette while leaving the object undamaged.
    Type: Grant
    Filed: March 25, 2013
    Date of Patent: January 6, 2015
    Inventor: Paul J. Taylor
  • Publication number: 20150004640
    Abstract: This analysis apparatus includes a transporter transporting the specimens to the first measurement unit and the second measurement unit, and a control portion so controlling the transporter as to transport a first specimen container, stored in the rack, storing a first specimen to the first measurement unit and as to transport a second specimen container, stored in the rack along with the first specimen container, storing a second specimen to the second measurement unit.
    Type: Application
    Filed: September 17, 2014
    Publication date: January 1, 2015
    Applicant: Sysmex Corporation
    Inventors: Takaaki Nagai, Yuichi Hamada, Masaharu Shibata
  • Patent number: 8921096
    Abstract: The invention concerns a pump cart for a biological liquid treatment installation, having a first lateral face (40), and a second lateral face (41) by which it is configured to be juxtaposed against a conveying network cart (1) of the installation and a front face (42) meeting the lateral faces (40, 41), and comprising at least one pump (414), a pump support (50) on which is mounted said pump (414), and a guide member for making said pump (414) movable in translation and on which said support (50) is mounted; said support (50) being movable in translation in a direction going from the first lateral face (40) towards the second lateral face (41); whereby said pump (414) is disposed at a predetermined location on said cart (2) depending on the type of treatment carried out.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: December 30, 2014
    Assignee: EMD Millipore Corporation
    Inventors: Jean-Louis Weissenbach, Rene Reinbigler, Virginie Buisson, Christine Abouayad El Idrissi, Sebastien Cirou
  • Patent number: 8921094
    Abstract: A system and method for the processing of nucleic acids containing fluids involving manipulation of magnetically responsive particles contained therein are disclosed. In the system, a holder holds a plurality of containers containing the fluids, a heating device applies thermal energy to the fluids for incubation, and a separating device magnetically separates the particles. The heating and separating devices move into at least one operative position for processing the fluids and at least one inoperative position with respect to the containers, in which the containers are kept stationary at least during and in-between incubating the fluids and manipulating the magnetically responsive particles.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: December 30, 2014
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Reto Keller, Thomas Meyer
  • Patent number: 8921095
    Abstract: A biological material fixed carrier enclosing tip, a biological material fixed carrier treatment apparatus, and a treatment method thereof. An object is to obviate attachment control and suction control for storing and retaining the carrier in the tip form vessel, to simplify complex reaction processes, and to make processing of the biological material fixed carrier to be easily executed as a result of a small-scale device configuration. The biological material fixed carrier enclosing tip comprises: a tip form vessel having an installation opening part that is installable to a nozzle, and a narrow tube that possesses an opening, through which fluid inflow and outflow is possible, that is narrower than the nozzle; a carrier in which a predetermined biological material is fixed or fixable, and has a size or a shape that is able to pass through the opening; and an enclosing section provided on the tip form vessel.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: December 30, 2014
    Assignee: Universal Bio Research Co., Ltd.
    Inventor: Hideji Tajima
  • Publication number: 20140377788
    Abstract: A blood glucose measurement unit, a blood glucose measurement method, and a blood glucose measurement system comprising the same are disclosed. According to one aspect of the present invention, provided is a blood glucose measurement unit comprising: a transparent first substrate consisting of a blood inflow region into which blood flows and a reaction region connected to the blood inflow region which are formed on one surface thereof; a transparent second substrate coupled to the first substrate and comprising a blood aperture through which the blood flowing into the blood inflow region passes; and a reagent distributed to the reaction region so as to react with the blood glucose of the blood which has flown into the blood inflow region.
    Type: Application
    Filed: January 11, 2012
    Publication date: December 25, 2014
    Applicant: Gachon University of Industry - Academic Cooperation Foundation
    Inventor: Sanghyo Kim
  • Publication number: 20140371112
    Abstract: The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.
    Type: Application
    Filed: September 3, 2014
    Publication date: December 18, 2014
    Applicant: University of Pittsburgh
    Inventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
  • Patent number: 8911987
    Abstract: An automated instrument for identification and/or characterization of a microbial agent present in a sample. The instrument includes (a) a sample removal apparatus operative to remove a test sample from a specimen container and add the test sample to a disposable separation device; (b) a separation and concentration apparatus operative on the separation device to separate the microbial agent from other components which may be present in the test sample and concentrate the microbial agent within the separation device; and (c) a identification and/or characterization module interrogating the concentrated microbial agent to identify and/or characterize the microbial agent.
    Type: Grant
    Filed: May 14, 2010
    Date of Patent: December 16, 2014
    Assignee: Biomerieux, Inc
    Inventors: Ronnie J. Robinson, Mark S. Wilson, Christopher S. Ronsick, John D. Walsh, Jones M. Hyman, Bradford G. Clay
  • Patent number: 8906674
    Abstract: A sample preparation apparatus comprising: a storage chamber that can store therein a liquid sample including an analysis target to be analyzed; a concentrated sample storage chamber that is provided to communicate with the storage chamber and that stores therein concentrated liquid having an analysis target having a higher concentration than that of the liquid sample; and an analysis target transportation section for transporting the analysis target included in the liquid sample stored in the storage chamber to the concentrated sample storage chamber. A cell analyzer is also disclosed.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: December 9, 2014
    Assignee: Sysmex Corporation
    Inventors: Ryuichiro Ebi, Koki Tajima
  • Patent number: 8906302
    Abstract: A reagent preparing device for preparing a reagent to be supplied to a measurement device for measuring a specimen, comprising: a first liquid storage unit for storing a first liquid; a reagent storage unit for storing a prepared reagent, including the first liquid and a second liquid different from the first liquid; a first liquid discarding unit for discarding the first liquid stored in the first liquid storage unit; and a controller configured for measuring an accumulated time of the first liquid in the first liquid storage unit; and controlling the first liquid discarding unit to discard the first liquid stored in the first liquid storage unit when the accumulated time reaches a predetermined time is disclosed. A specimen measuring device and a reagent preparing method are also disclosed.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: December 9, 2014
    Assignee: Sysmex Corporation
    Inventors: Noriyuki Nakanishi, Koichi Okubo, Masahiko Oguro, Tomoyuki Asahara
  • Publication number: 20140356876
    Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue, capturing the sectioned tissue, and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, and capturing each sectioned tissue, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.
    Type: Application
    Filed: June 10, 2014
    Publication date: December 4, 2014
    Inventor: Timothy Ragan
  • Patent number: 8895312
    Abstract: A microfluidic device for mitochondria analysis includes an inlet coupled to a first access channel, an outlet coupled to a second access channel, and a plurality of trapping channels fluidically coupled at one end to the first access channel and fluidically coupled at an opposing end to the second access channel, each trapping channel has a cross-sectional dimension about 2 ?m in one direction and a cross-sectional dimension between about 0.45 and about 0.75 ?m in a second direction.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: November 25, 2014
    Assignee: The Regents of the University of California
    Inventors: Peter Burke, Katayoun Zand, Ted Pham, Antonio Davila, Douglas Wallace
  • Patent number: 8892254
    Abstract: A robot controller includes queues, a storage unit, and an execution control unit. The queues are provided for respective controlled groups serving as controlled units. The storage unit stores therein instructions directed to the respective controlled groups, one at a time, from a bottom end of each of the queues. When having accepted a predetermined operation request, the execution control unit simultaneously fetches the instructions directed to the controlled groups, one for each of the controlled groups at a time, from tops of the queues, and makes all of the controlled groups simultaneously start the operations based on such instructions. If there is any controlled group to which no corresponding instruction exists, the storage unit stores therein a no-operation instruction. If the fetched instruction is the no-operation instruction, the execution control unit keeps the controlled group from operating until an instruction is fetched next time.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: November 18, 2014
    Assignee: Kabushiki Kaisha Yaskawa Denki
    Inventor: Takahiro Maeda
  • Patent number: 8883489
    Abstract: Apparatus for performing an assay to detect the presence of an analyte in a test sample. A housing defines a slot for receiving a sample collector, and a capsule contains a buffer liquid, the capsule being sealed by an openable lid, and being connected to the housing such that insertion of a sample collector into the slot causes the lid to open releasing the buffer liquid into the slot. The housing further defines an incubation chamber containing or configured to receive a reagent, and an aperture permitting liquid communication between said slot and the incubation chamber. The apparatus comprises one or more test elements, a substantially liquid tight sealing member separating the incubation chamber and the test element(s), and an activation mechanism operable to open said liquid tight sealing member thereby bringing at least a portion of the or each test element into liquid communication with said incubation chamber.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: November 11, 2014
    Assignee: Concateno UK Limited
    Inventors: Alan Pang, Gordon Jowett, Barry Lillis, Jack Fairbank